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Conserved domains on  [gi|1084922230|gb|OGR40631|]
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4-carboxymuconolactone decarboxylase [Desulfovibrionales bacterium GWA2_65_9]

Protein Classification

perox_w_seleSAM family protein( domain architecture ID 10024490)

perox_w_seleSAM family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
perox_w_seleSAM TIGR04169
alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Members of this family ...
 2-109 1.80e-63

alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Members of this family are usually annotated as putative carboxymuconolactone decarboxylases, are related also to alkylhydroperoxidase AhpD, and contain a peroxidase-like Cys-X-X-Cys putative redox-active disulfide. All members occur in genomes with a radical SAM protein of family TIGR04167, which occasionally are selenoproteins.


:

Pssm-ID: 200420  Cd Length: 109  Bit Score: 187.74  E-value: 1.80e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922230   2 TYYDPKDLAKFGDIGKNAPEAAKKFFAYYEEVFAEGALTAREKALIALAVAHAVQCPYCIDAYTGTCLEKGSNADEMTEA 81
Cdd:TIGR04169   2 TYYDPADLAKFGEIGEDAPELADKFFDYYGAVFEEGALSEREKALIALAVAHAVQCPYCIDAYTQTSLEKGANKEQMMEA 81

                          90       100
                  ....*....|....*....|....*...
gi 1084922230  82 VHVAAAIRGGATLVHGVQMRNILDKKAF 109
Cdd:TIGR04169  82 VHVAAAIRGGATLVHGVQMKNKAKKLSF 109
 
Name Accession Description Interval E-value
perox_w_seleSAM TIGR04169
alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Members of this family ...
 2-109 1.80e-63

alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Members of this family are usually annotated as putative carboxymuconolactone decarboxylases, are related also to alkylhydroperoxidase AhpD, and contain a peroxidase-like Cys-X-X-Cys putative redox-active disulfide. All members occur in genomes with a radical SAM protein of family TIGR04167, which occasionally are selenoproteins.


Pssm-ID: 200420  Cd Length: 109  Bit Score: 187.74  E-value: 1.80e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922230   2 TYYDPKDLAKFGDIGKNAPEAAKKFFAYYEEVFAEGALTAREKALIALAVAHAVQCPYCIDAYTGTCLEKGSNADEMTEA 81
Cdd:TIGR04169   2 TYYDPADLAKFGEIGEDAPELADKFFDYYGAVFEEGALSEREKALIALAVAHAVQCPYCIDAYTQTSLEKGANKEQMMEA 81

                          90       100
                  ....*....|....*....|....*...
gi 1084922230  82 VHVAAAIRGGATLVHGVQMRNILDKKAF 109
Cdd:TIGR04169  82 VHVAAAIRGGATLVHGVQMKNKAKKLSF 109
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 12-100 1.44e-21

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 81.92  E-value: 1.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922230  12 FGDIGKNAPEAAKKFFAYYEEVFAEGALTAREKALIALAVAHAVQCPYCIDAYTGTCLEKGSNADEMTEAVHVAAAIRGG 91
Cdd:COG0599    15 LEALAEFAPEFAEAFEALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAAVYAGF 94


                  ....*....
gi 1084922230  92 ATLVHGVQM 100
Cdd:COG0599    95 PAALNALRA 103
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 20-99 4.05e-14

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 61.94  E-value: 4.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922230  20 PEAAKKFFAYYEEVFAEGALTAREKALIALAVAHAVQCPYCIDAYTGTCLEKGSNADEMTEAVHVAAAIRGGATLVHGVQ 99
Cdd:pfam02627   1 PELLAALTALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALA 80
 
Name Accession Description Interval E-value
perox_w_seleSAM TIGR04169
alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Members of this family ...
 2-109 1.80e-63

alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Members of this family are usually annotated as putative carboxymuconolactone decarboxylases, are related also to alkylhydroperoxidase AhpD, and contain a peroxidase-like Cys-X-X-Cys putative redox-active disulfide. All members occur in genomes with a radical SAM protein of family TIGR04167, which occasionally are selenoproteins.


Pssm-ID: 200420  Cd Length: 109  Bit Score: 187.74  E-value: 1.80e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922230   2 TYYDPKDLAKFGDIGKNAPEAAKKFFAYYEEVFAEGALTAREKALIALAVAHAVQCPYCIDAYTGTCLEKGSNADEMTEA 81
Cdd:TIGR04169   2 TYYDPADLAKFGEIGEDAPELADKFFDYYGAVFEEGALSEREKALIALAVAHAVQCPYCIDAYTQTSLEKGANKEQMMEA 81

                          90       100
                  ....*....|....*....|....*...
gi 1084922230  82 VHVAAAIRGGATLVHGVQMRNILDKKAF 109
Cdd:TIGR04169  82 VHVAAAIRGGATLVHGVQMKNKAKKLSF 109
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 12-100 1.44e-21

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 81.92  E-value: 1.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922230  12 FGDIGKNAPEAAKKFFAYYEEVFAEGALTAREKALIALAVAHAVQCPYCIDAYTGTCLEKGSNADEMTEAVHVAAAIRGG 91
Cdd:COG0599    15 LEALAEFAPEFAEAFEALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAAVYAGF 94


                  ....*....
gi 1084922230  92 ATLVHGVQM 100
Cdd:COG0599    95 PAALNALRA 103
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 20-99 4.05e-14

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 61.94  E-value: 4.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922230  20 PEAAKKFFAYYEEVFAEGALTAREKALIALAVAHAVQCPYCIDAYTGTCLEKGSNADEMTEAVHVAAAIRGGATLVHGVQ 99
Cdd:pfam02627   1 PELLAALTALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALA 80
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 19-65 4.60e-10

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 52.96  E-value: 4.60e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1084922230  19 APEAAKKFFAYYEEVFAEGALTAREKALIALAVAHAVQCPYCIDAYT 65
Cdd:COG2128     2 SPELLKAFLALSGALMAKGGLSPRERELVALRVSQINGCAYCLDAHT 48
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 37-86 2.56e-07

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 43.90  E-value: 2.56e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1084922230  37 GALTAREKALIALAVAHAVQCPYCIDAYTGTCLEKGSNADEMTEAVHVAA 86
Cdd:TIGR00778   1 GALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAWAA 50
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
 20-60 3.01e-05

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 40.86  E-value: 3.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1084922230  20 PEAAKKFFAYYEEVF-AEGALTAREKALIALAVAHAVQCPYC 60
Cdd:TIGR01926  40 PEALRARTAYFNDLMlGEGGLSRAERELIAVVVSRANGCVYC 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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