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Conserved domains on  [gi|1084248262|gb|OGM35506|]
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hypothetical protein A3D84_05540 [Candidatus Woesebacteria bacterium RIFCSPHIGHO2_02_FULL_42_20]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 4-292 4.45e-22

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 95.68  E-value: 4.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262   4 AIYSP-YLDTLGGGERYVLSVARALIETGWNVDI------ESSDQNLGQKVKKRFGFDLVKANFVESVQRGNGYDLCFWL 76
Cdd:cd03801     3 LLLSPeLPPPVGGAERHVRELARALAARGHDVTVltpadpGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLRLRK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  77 SD------------------GSVPTLFARCNVLHFQRPFSGVDGKS-LLNRMKFF--RINSVVVNSVFTKKWIDTEY--- 132
Cdd:cd03801    83 FDvvhahgllaallaallalLLGAPLVVTLHGAEPGRLLLLLAAERrLLARAEALlrRADAVIAVSEALRDELRALGgip 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 133 PKKSIVVYPPVDID--------KLKAGRKENMLLYVGRFSQLeqsKGQDVLVKNFiNLIEAGLRGWKLVLAGAS--NVGR 202
Cdd:cd03801   163 PEKIVVIPNGVDLErfspplrrKLGIPPDRPVLLFVGRLSPR---KGVDLLLEAL-AKLLRRGPDVRLVIVGGDgpLRAE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 203 TGFVDSLIKESVnypiTIIENAAFREIVKLYSKAKIFwsaagygVdeksTPEKMEHFGISVVEAMASGAVPIIYDGGGHG 282
Cdd:cd03801   239 LEELELGLGDRV----RFLGFVPDEELPALYAAADVF-------V----LPSRYEGFGLVVLEAMAAGLPVVATDVGGLP 303

                         330
                  ....*....|
gi 1084248262 283 EIIETGKTGY 292
Cdd:cd03801   304 EVVEDGEGGL 313
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 4-292 4.45e-22

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 95.68  E-value: 4.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262   4 AIYSP-YLDTLGGGERYVLSVARALIETGWNVDI------ESSDQNLGQKVKKRFGFDLVKANFVESVQRGNGYDLCFWL 76
Cdd:cd03801     3 LLLSPeLPPPVGGAERHVRELARALAARGHDVTVltpadpGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLRLRK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  77 SD------------------GSVPTLFARCNVLHFQRPFSGVDGKS-LLNRMKFF--RINSVVVNSVFTKKWIDTEY--- 132
Cdd:cd03801    83 FDvvhahgllaallaallalLLGAPLVVTLHGAEPGRLLLLLAAERrLLARAEALlrRADAVIAVSEALRDELRALGgip 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 133 PKKSIVVYPPVDID--------KLKAGRKENMLLYVGRFSQLeqsKGQDVLVKNFiNLIEAGLRGWKLVLAGAS--NVGR 202
Cdd:cd03801   163 PEKIVVIPNGVDLErfspplrrKLGIPPDRPVLLFVGRLSPR---KGVDLLLEAL-AKLLRRGPDVRLVIVGGDgpLRAE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 203 TGFVDSLIKESVnypiTIIENAAFREIVKLYSKAKIFwsaagygVdeksTPEKMEHFGISVVEAMASGAVPIIYDGGGHG 282
Cdd:cd03801   239 LEELELGLGDRV----RFLGFVPDEELPALYAAADVF-------V----LPSRYEGFGLVVLEAMAAGLPVVATDVGGLP 303

                         330
                  ....*....|
gi 1084248262 283 EIIETGKTGY 292
Cdd:cd03801   304 EVVEDGEGGL 313
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 153-292 1.21e-15

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 73.46  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 153 KENMLLYVGRfsqLEQSKGQDVLVKNFINLIEAGLRgWKLVLAGASNvgrtgFVDSLIKESVNYPI----TIIENAAFRE 228
Cdd:pfam00534   1 KKKIILFVGR---LEPEKGLDLLIKAFALLKEKNPN-LKLVIAGDGE-----EEKRLKKLAEKLGLgdnvIFLGFVSDED 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084248262 229 IVKLYSKAKIFWSAAGYgvdekstpekmEHFGISVVEAMASGAVPIIYDGGGHGEIIETGKTGY 292
Cdd:pfam00534  72 LPELLKIADVFVLPSRY-----------EGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGF 124
PLN02949 PLN02949
transferase, transferring glycosyl groups
 117-280 8.66e-11

transferase, transferring glycosyl groups


Pssm-ID: 215511 [Multi-domain]  Cd Length: 463  Bit Score: 62.83  E-value: 8.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 117 VVVNSVFTKKWIDTEY--PKKSIVVYPPVDIDKLKA---GRKENMLlYVGRFSQLEQSKGQDVLVKNFINLIEAG---LR 188
Cdd:PLN02949  224 AMVNSSWTKSHIEALWriPERIKRVYPPCDTSGLQAlplERSEDPP-YIISVAQFRPEKAHALQLEAFALALEKLdadVP 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 189 GWKLVLAGA-SNVGRTGFVDSL--------IKESVNYPitiiENAAFREIVKLYSKAkifwsAAGYgvdekstpEKM--E 257
Cdd:PLN02949  303 RPKLQFVGScRNKEDEERLQKLkdrakelgLDGDVEFH----KNVSYRDLVRLLGGA-----VAGL--------HSMidE 365

                         170       180
                  ....*....|....*....|...
gi 1084248262 258 HFGISVVEAMASGAVPIIYDGGG 280
Cdd:PLN02949  366 HFGISVVEYMAAGAVPIAHNSAG 388
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 232-292 1.34e-07

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 49.60  E-value: 1.34e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1084248262 232 LYSKAKIFWSaagygvdekstPEKMEHFGISVVEAMASGAVPIIYDGGGHGEIIETGKTGY 292
Cdd:COG0438    17 LLAAADVFVL-----------PSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGL 66
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 4-292 4.45e-22

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 95.68  E-value: 4.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262   4 AIYSP-YLDTLGGGERYVLSVARALIETGWNVDI------ESSDQNLGQKVKKRFGFDLVKANFVESVQRGNGYDLCFWL 76
Cdd:cd03801     3 LLLSPeLPPPVGGAERHVRELARALAARGHDVTVltpadpGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLRLRK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  77 SD------------------GSVPTLFARCNVLHFQRPFSGVDGKS-LLNRMKFF--RINSVVVNSVFTKKWIDTEY--- 132
Cdd:cd03801    83 FDvvhahgllaallaallalLLGAPLVVTLHGAEPGRLLLLLAAERrLLARAEALlrRADAVIAVSEALRDELRALGgip 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 133 PKKSIVVYPPVDID--------KLKAGRKENMLLYVGRFSQLeqsKGQDVLVKNFiNLIEAGLRGWKLVLAGAS--NVGR 202
Cdd:cd03801   163 PEKIVVIPNGVDLErfspplrrKLGIPPDRPVLLFVGRLSPR---KGVDLLLEAL-AKLLRRGPDVRLVIVGGDgpLRAE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 203 TGFVDSLIKESVnypiTIIENAAFREIVKLYSKAKIFwsaagygVdeksTPEKMEHFGISVVEAMASGAVPIIYDGGGHG 282
Cdd:cd03801   239 LEELELGLGDRV----RFLGFVPDEELPALYAAADVF-------V----LPSRYEGFGLVVLEAMAAGLPVVATDVGGLP 303

                         330
                  ....*....|
gi 1084248262 283 EIIETGKTGY 292
Cdd:cd03801   304 EVVEDGEGGL 313
GT4_ALG11-like cd03806
alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related ...
 8-280 1.41e-20

alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides.


Pssm-ID: 340835 [Multi-domain]  Cd Length: 419  Bit Score: 91.90  E-value: 1.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262   8 PYLDTLGGGERyVLSVA-RALIETGWNV-------DIESSDQNLGQKVKKRFGFDL----------VKANFVESvqrgnG 69
Cdd:cd03806     8 PYCNAGGGGER-VLWCAvKATQKAYPNNicviytgDTDSSPEEILEKVESRFNIDLdsprivffllKYRKLVEA-----K 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  70 YDLCFWL---SDGS-----------VPT----------------LFARCNV---LHF------------QRPFSGVD--- 101
Cdd:cd03806    82 TYPRFTLlgqALGSmilgfeallklVPDvfidtmgypftyplvrLLGGCPVvayVHYptistdmlnkvrSREASYNNdst 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 102 --GKSLLNRMKFF--------------RINSVVVNSVFTKKWIDT--EYPKKSIVVYPPVDIDKLKA-----GRKENMLL 158
Cdd:cd03806   162 iaRSSVLSIAKLLyyrlfaflyglagsFADVVMVNSTWTYNHIRQlwKRNIKPSIVYPPCDTEELTKlpideKTRENQIL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 159 YVGRFS-------QLEQSKGqdvLVKNfinLIEAGLRGWKLVLAGAS-NVGRTGFVDSL----IKESVNYPITIIENAAF 226
Cdd:cd03806   242 SIAQFRpeknhplQLRAFAE---LLKR---LPESIRSNPKLVLIGSCrNEEDKERVEALkllaKELILEDSVEFVVDAPY 315

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1084248262 227 REIVKLYSKAKIfwsaagyGVDekstpeKM--EHFGISVVEAMASGAVPIIYDGGG 280
Cdd:cd03806   316 EELKELLSTASI-------GLH------TMwnEHFGIGVVEYMAAGLIPLAHASAG 358
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 153-292 1.21e-15

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 73.46  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 153 KENMLLYVGRfsqLEQSKGQDVLVKNFINLIEAGLRgWKLVLAGASNvgrtgFVDSLIKESVNYPI----TIIENAAFRE 228
Cdd:pfam00534   1 KKKIILFVGR---LEPEKGLDLLIKAFALLKEKNPN-LKLVIAGDGE-----EEKRLKKLAEKLGLgdnvIFLGFVSDED 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084248262 229 IVKLYSKAKIFWSAAGYgvdekstpekmEHFGISVVEAMASGAVPIIYDGGGHGEIIETGKTGY 292
Cdd:pfam00534  72 LPELLKIADVFVLPSRY-----------EGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGF 124
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
 113-291 5.19e-15

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 75.01  E-value: 5.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 113 RINSVVVNSVFTKKWIDTEYPKKSIVVYPPVDIDKLK-AGRKENMLLYVGRFSQLeqsKGQDVLVKNFINLieaglrGWK 191
Cdd:cd03804   157 RVDLFIANSQFVARRIKKFYGRESTVIYPPVDTDAFApAADKEDYYLTASRLVPY---KRIDLAVEAFNEL------PKR 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 192 LVLAGasnvgrTGFVDSLIKESVNYPITIIENAAFREIVKLYSKAKIFWSAAgygvdekstpekMEHFGISVVEAMASGA 271
Cdd:cd03804   228 LVVIG------DGPDLDRLRAMASPNVEFLGYQPDEVLKELLSKARAFVFAA------------EEDFGIVPVEAQACGT 289

                         170       180
                  ....*....|....*....|
gi 1084248262 272 VPIIYDGGGHGEIIETGKTG 291
Cdd:cd03804   290 PVIAFGKGGALETVRPGPTG 309
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 13-284 1.84e-14

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 73.55  E-value: 1.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  13 LGGGERYVLSVARALIE-------------TGWNVDIESSDQNLGQKVKKRFGFDLVKANFVE--SVQRGNGYDLcFWLS 77
Cdd:cd03809    13 LTGIGRYTRELLKALAKndpdesvlavpplPGELLRLLREYPELSLGVIKIKLWRELALLRWLqiLLPKKDKPDL-LHSP 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  78 DGSVPTLFARCNV-------LHFQRPFSGVDGKSLLNRMKFFRI----NSVVVNSVFTK----KWIDtEYPKKSIVVYPP 142
Cdd:cd03809    92 HNTAPLLLKGCPQvvtihdlIPLRYPEFFPKRFRLYYRLLLPISlrraDAIITVSEATRddiiKFYG-VPPEKIVVIPLG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 143 VD----------IDKLKAGRKENMLLYVGrfsQLEQSKGQDVLVKNFINLIEAGlRGWKLVLAGASNVGRTGFVDSLIKE 212
Cdd:cd03809   171 VDpsffppesaaVLIAKYLLPEPYFLYVG---TLEPRKNHERLLKAFALLKKQG-GDLKLVIVGGKGWEDEELLDLVKKL 246

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1084248262 213 SVNYPITIIENAAFREIVKLYSKAKIFWSAAGYgvdekstpekmEHFGISVVEAMASGaVPIIY-DGGGHGEI 284
Cdd:cd03809   247 GLGGRVRFLGYVSDEDLPALYRGARAFVFPSLY-----------EGFGLPVLEAMACG-TPVIAsNISVLPEV 307
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 14-292 4.57e-12

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 66.23  E-value: 4.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  14 GGGERYVLSVARALIETGWNVDI-------ESSDQNLGQKVKKRFGFDLVKANFVES---------VQRGNGYDLCFWLS 77
Cdd:cd03811    12 GGAERVLLNLANALDKRGYDVTLvllrdegDLDKQLNGDVKLIRLLIRVLKLIKLGLlkailklkrILKRAKPDVVISFL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  78 DgsVPTLFARcNVLHFQRPFSGV-----------DGKSLLNRMKFFRINSVVVNSVFTKKWIDTEYP---KKSIVVYPPV 143
Cdd:cd03811    92 G--FATYIVA-KLAAARSKVIAWihsslsklyylKKKLLLKLKLYKKADKIVCVSKGIKEDLIRLGPsppEKIEVIYNPI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 144 DIDKLKAGRKEN---------MLLYVGRFSqlEQsKGQDVLVKNFINLIEAGLrGWKLVLAGasnVGrtgfvdSLIKESV 214
Cdd:cd03811   169 DIDRIRALAKEPilnepedgpVILAVGRLD--PQ-KGHDLLIEAFAKLRKKYP-DVKLVILG---DG------PLREELE 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 215 NYpitiIENAAFREIVKL----------YSKAKIFWSAAGYgvdekstpekmEHFGISVVEAMASGAVPIIYDGGGHGEI 284
Cdd:cd03811   236 KL----AKELGLAERVIFlgfqsnpypyLKKADLFVLSSRY-----------EGFPNVLLEAMALGTPVVSTDCPGPREI 300


                  ....*...
gi 1084248262 285 IETGKTGY 292
Cdd:cd03811   301 LDDGENGL 308
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 2-292 8.02e-12

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 65.34  E-value: 8.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262   2 KAAIYSPYLDTLGGGERYVLSVARALIETGWNVDIESSDQNLGQ-------KVKKRFGFDLVKANFVESVQ--------- 65
Cdd:cd03820     1 KIAIVIPSISNAGGAERVAINLANHLAKKGYDVTIISLDSAEKPpfyelddNIKIKNLGDRKYSHFKLLLKyfkkvrrlr 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  66 ---RGNGYD---------LCFwlsdgsVPTLFARCNVL---HFQRPFSGVDGKSLLNRMK-FFRINSVVVNSVFTKKWID 129
Cdd:cd03820    81 kylKNNKPDvvisfrtslLTF------LALIGLKSKLIvweHNNYEAYNKGLRRLLLRRLlYKRADKIVVLTEADKLKKY 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 130 TEYPKKSIVVYPPVDIDKLKA--GRKENMLLYVGRfsqLEQSKGQDVLVKNFINLIEAgLRGWKLVLAGAsnvgrtG--- 204
Cdd:cd03820   155 KQPNSNVVVIPNPLSFPSEEPstNLKSKRILAVGR---LTYQKGFDLLIEAWALIAKK-HPDWKLRIYGD------Gper 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 205 -----FVDSL-IKESVNYPitiienAAFREIVKLYSKAKIFWSaagygvdekstPEKMEHFGISVVEAMASGAVPIIYDG 278
Cdd:cd03820   225 eelekLIDKLgLEDRVKLL------GPTKNIAEEYANSSIFVL-----------SSRYEGFPMVLLEAMAYGLPIISFDC 287

                         330
                  ....*....|....*
gi 1084248262 279 -GGHGEIIETGKTGY 292
Cdd:cd03820   288 pTGPSEIIEDGENGL 302
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 11-292 1.96e-11

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 64.57  E-value: 1.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  11 DTlGGGERYVLSVARALIETGWNVDI----ESSDQ----NLGQKVKKR---FG-FDLVK--------ANFVESVQR---- 66
Cdd:cd03800    19 DT-GGQNVYVLELARALAELGYQVDIftrrISPADpevvEIAPGARVIrvpAGpPEYLPkeelwpylEEFADGLLRfiar 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  67 -GNGYDLC---FWLSdGSVPTLFAR------CNVLH----FQRPFSGVDGKSLLNRmkffRI----------NSVVVNS- 121
Cdd:cd03800    98 eGGRYDLIhshYWDS-GLVGALLARrlgvplVHTFHslgrVKYRHLGAQDTYHPSL----RItaeeqileaaDRVIASTp 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 122 ---VFTKKWIDTeYPKKSIVVYPPVDID-------------KLKAGRKENMLLYVGRFSQLeqsKGQDVLVKNFINLIEA 185
Cdd:cd03800   173 qeaDELISLYGA-DPSRINVVPPGVDLErffpvdraearraRLLLPPDKPVVLALGRLDPR---KGIDTLVRAFAQLPEL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 186 GLRGWKLVLAGASNVG-------RTGFVDSL-IKESVNYPITIIENaafrEIVKLYSKAKIFwsaagygvdekSTPEKME 257
Cdd:cd03800   249 RELANLVLVGGPSDDPlsmdreeLAELAEELgLIDRVRFPGRVSRD----DLPELYRAADVF-----------VVPSLYE 313

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1084248262 258 HFGISVVEAMASGaVPII-YDGGGHGEIIETGKTGY 292
Cdd:cd03800   314 PFGLTAIEAMACG-TPVVaTAVGGLQDIVRDGRTGL 348
PLN02949 PLN02949
transferase, transferring glycosyl groups
 117-280 8.66e-11

transferase, transferring glycosyl groups


Pssm-ID: 215511 [Multi-domain]  Cd Length: 463  Bit Score: 62.83  E-value: 8.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 117 VVVNSVFTKKWIDTEY--PKKSIVVYPPVDIDKLKA---GRKENMLlYVGRFSQLEQSKGQDVLVKNFINLIEAG---LR 188
Cdd:PLN02949  224 AMVNSSWTKSHIEALWriPERIKRVYPPCDTSGLQAlplERSEDPP-YIISVAQFRPEKAHALQLEAFALALEKLdadVP 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 189 GWKLVLAGA-SNVGRTGFVDSL--------IKESVNYPitiiENAAFREIVKLYSKAkifwsAAGYgvdekstpEKM--E 257
Cdd:PLN02949  303 RPKLQFVGScRNKEDEERLQKLkdrakelgLDGDVEFH----KNVSYRDLVRLLGGA-----VAGL--------HSMidE 365

                         170       180
                  ....*....|....*....|...
gi 1084248262 258 HFGISVVEAMASGAVPIIYDGGG 280
Cdd:PLN02949  366 HFGISVVEYMAAGAVPIAHNSAG 388
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
154-292 1.80e-10

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 58.29  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 154 ENMLLYVGRFSqlEQSKGQDVLVKNFINLIEAGlRGWKLVLAGAsnvgrtGFVDSLIKESVNYPITIIenaaF----REI 229
Cdd:pfam13692   1 RPVILFVGRLH--PNVKGVDYLLEAVPLLRKRD-NDVRLVIVGD------GPEEELEELAAGLEDRVI----FtgfvEDL 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084248262 230 VKLYSKAKIFwsAAgygvdekstPEKMEHFGISVVEAMASGaVPII-YDGGGHGEIIEtGKTGY 292
Cdd:pfam13692  68 AELLAAADVF--VL---------PSLYEGFGLKLLEAMAAG-LPVVaTDVGGIPELVD-GENGL 118
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 13-292 4.69e-10

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 60.30  E-value: 4.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  13 LGGGERYVLSVARALIETGWNVDI------------ESSDQNLGQKV---------KKRF-----GFDLVKANFVESVQR 66
Cdd:cd03805    12 IGGAERLVVDAALALQSRGHEVTIytshhdpshcfeETKDGTLPVRVrgdwlprsiFGRFhalcaYLRMLYLALYLLLFS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  67 GNGYDLcfWLSDgSVPT------LFARCNVL---HF------QRpfsgvdgKSLLNRM--KFFRI---------NSVVVN 120
Cdd:cd03805    92 GEKYDV--FIVD-QVSAcvpllkLFRPSKILfycHFpdqllaQR-------KSLLKRLyrKPFDWleefttgmaDQIVVN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 121 SVFTKK-WIDT---EYPKKSIVVYPPVDID------------KLKAGRKENMLLYVGRFsqlEQSKGQDVLVKNFINLIE 184
Cdd:cd03805   162 SNFTAGvFKKTfpsLAKNPPEVLYPCVDTDsfdstsedpdpgDLIAKSNKKFFLSINRF---ERKKNIALAIEAFAKLKQ 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 185 aGLRGW---KLVLAGasnvgrtGFvDSLIKESVNYPITIIENAAFREIVK----------------LYSKAKifwsAAGY 245
Cdd:cd03805   239 -KLPEFenvRLVIAG-------GY-DPRVAENVEYLEELQRLAEELLNVEdqvlflrsisdsqkeqLLSSAL----ALLY 305

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1084248262 246 gvdeksTPEKmEHFGISVVEAMASGaVPII-YDGGGHGEIIETGKTGY 292
Cdd:cd03805   306 ------TPSN-EHFGIVPLEAMYAG-KPVIaCNSGGPLETVVEGVTGF 345
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 2-292 1.68e-09

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 57.41  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262   2 KAAIYSPYLDTLGGGERYVLSVARALIETGWNVDIessdqnlgqkvkkrFGFDLVKANFVESVQRGNGYDL--CFWLSDG 79
Cdd:cd01635     1 ILLVTGEYPPLRGGLELHVRALARALAALGHEVTV--------------LALLLLALRRILKKLLELKPDVvhAHSPHAA 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  80 SVPTLFARcnvlhfqrpfsgvdgksllnrmKFFRINSVVVNSVFTKKWIDTEYPKKSIVVYPpvdidklkaGRKENMLLY 159
Cdd:cd01635    67 ALAALLAA----------------------RLLGIPIVVTVHGPDSLESTRSELLALARLLV---------SLPLADKVS 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 160 VGRfsqLEQSKGQDVLVKNFINLIEAGLRgWKLVLAGASNVGRTGFVDSLIKESVNYPITIIENAAFREIVKLYSKAKIF 239
Cdd:cd01635   116 VGR---LVPEKGIDLLLEALALLKARLPD-LVLVLVGGGGEREEEEALAAALGLLERVVIIGGLVDDEVLELLLAAADVF 191

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1084248262 240 WSAAGYgvdekstpekmEHFGISVVEAMASGAVPIIYDGGGHGEIIETGKTGY 292
Cdd:cd01635   192 VLPSRS-----------EGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGL 233
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 132-288 3.34e-08

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 54.68  E-value: 3.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 132 YPKKSIVVYPPVDIDKLKAG----RKEN------MLLYVGRfsqLEQSKGQDVLVKNFINLIEAGlRGWKLVLAGASNVG 201
Cdd:cd03821   172 LEPPIAVIPNGVDIPEFDPGlrdrRKHNgledrrIILFLGR---IHPKKGLDLLIRAARKLAEQG-RDWHLVIAGPDDGA 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 202 RTGFVDSLIKESVNYPITIIEnaafreivKLYSKAKifwSAAGYGVDEKSTPEKMEHFGISVVEAMASGAVPIIYDGGGH 281
Cdd:cd03821   248 YPAFLQLQSSLGLGDRVTFTG--------PLYGEAK---WALYASADLFVLPSYSENFGNVVAEALACGLPVVITDKCGL 316


                  ....*..
gi 1084248262 282 GEIIETG 288
Cdd:cd03821   317 SELVEAG 323
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 134-293 1.18e-07

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 52.67  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 134 KKSIVVYP-PVDIDKL-----KAGRK-------ENMLLYVGRFSQleqSKGQDVLVKNFINLIEAglRGWKLVLAG---- 196
Cdd:cd03817   168 KGPIEVIPnGIDLDKFekplnTEERRklglppdEPILLYVGRLAK---EKNIDFLLRAFAELKKE--PNIKLVIVGdgpe 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 197 -------------ASNVGRTGFVDSlikesvnypitiienaafREIVKLYSKAKIFWSAAgygvdekstpeKMEHFGISV 263
Cdd:cd03817   243 reelkelarelglADKVIFTGFVPR------------------EELPEYYKAADLFVFAS-----------TTETQGLVY 293

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1084248262 264 VEAMASGaVPII-YDGGGHGEIIETGKTGYT 293
Cdd:cd03817   294 LEAMAAG-LPVVaAKDPAASELVEDGENGFL 323
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 14-292 1.19e-07

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 52.68  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  14 GGGERYVLSVARALIETGWNVD---------------IESSDQNLGQKVKKRFGFDLVKAnfVESVQRGNGYDLCFWLSD 78
Cdd:cd03802    18 GGTELVVSALTEGLVRRGHEVTlfapgdshtsaplvaVIPRALRLDPIPQESKLAELLEA--LEVQLRASDFDVIHNHSY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  79 GSVPtLFARCNV------LHFQrpfsgVDGKSLLNRMKFFRINSVVVNSVFTKKWIDTEYPkksIVVYPPVDIDKLK-AG 151
Cdd:cd03802    96 DWLP-PFAPLIGtpfvttLHGP-----SIPPSLAIYAAEPPVNYVSISDAQRAATPPIDYL---TVVHNGLDPADYRfQP 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 152 RKENMLLYVGRFSQleqSKGQDVLvknfinlIEAGLR-GWKLVLAGasnvgrtgfvdslikesvnypiTIIENAAFREIV 230
Cdd:cd03802   167 DPEDYLAFLGRIAP---EKGLEDA-------IRVARRaGLPLKIAG----------------------KVRDEDYFYYLQ 214

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1084248262 231 KLYSKAKIFWsaagYGvdEKSTPEKMEH----------------FGISVVEAMASGaVPII-YDGGGHGEIIETGKTGY 292
Cdd:cd03802   215 EPLPGPRIEF----IG--EVGHDEKQELlggarallfpinwdepFGLVMIEAMACG-TPVIaYRRGGLPEVIQHGETGF 286
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 232-292 1.34e-07

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 49.60  E-value: 1.34e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1084248262 232 LYSKAKIFWSaagygvdekstPEKMEHFGISVVEAMASGAVPIIYDGGGHGEIIETGKTGY 292
Cdd:COG0438    17 LLAAADVFVL-----------PSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGL 66
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 6-292 2.67e-07

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 51.56  E-value: 2.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262   6 YSPYLdtLGGGERYVLSVARALIETGWNVDIESSDQNLGQKVKKRFGFDLVKANFVESVQRGNGYDLcFWLSDGSVPTLF 85
Cdd:cd03823     9 YPPQR--VGGAEISVHDLAEALVAEGHEVAVLTAGVGPPGQATVARSVVRYRRAPDETLPLALKRRG-YELFETYNPGLR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262  86 ARC---------NVLHFQRpFSGVdGKSLLN---------------------RMKFFRINS--VVVNSVFTKK-WIDTEY 132
Cdd:cd03823    86 RLLarlledfrpDVVHTHN-LSGL-GASLLDaardlgipvvhtlhdywllcpRQFLFKKGGdaVLAPSRFTANlHEANGL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 133 PKKSIVVYP---PVDIDKLKAGRKENMLLYVGRFSQLEQSKGQDVLVKNFINLIEaglRGWKLVLAGasnvgrtGFVDSL 209
Cdd:cd03823   164 FSARISVIPnavEPDLAPPPRRRPGTERLRFGYIGRLTEEKGIDLLVEAFKRLPR---EDIELVIAG-------HGPLSD 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 210 IKE-SVNYPITIIENAAFREIVKLYSKAKIFWSAAGYgvdekstpekMEHFGISVVEAMASGaVPII-YDGGGHGEIIET 287
Cdd:cd03823   234 ERQiEGGRRIAFLGRVPTDDIKDFYEKIDVLVVPSIW----------PEPFGLVVREAIAAG-LPVIaSDLGGIAELIQP 302


                  ....*
gi 1084248262 288 GKTGY 292
Cdd:cd03823   303 GVNGL 307
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 133-292 3.24e-07

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 51.44  E-value: 3.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 133 PKKSIVVYPPVDID------KLKAGRKENM-LLYVGRFsqLEQsKGQDVLVKNFINLIEAGLRgWKLVLAGA--SNVGRT 203
Cdd:cd03808   161 KKKKTVLIPGSGVDldrfqySPESLPSEKVvFLFVARL--LKD-KGIDELIEAAKILKKKGPN-VRFLLVGDgeLENPSE 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 204 GFVDSLIKESvnypitIIENAAFRE-IVKLYSKAKIFwsaagygvdekSTPEKMEHFGISVVEAMASGaVPII-YDGGGH 281
Cdd:cd03808   237 ILIEKLGLEG------RIEFLGFRSdVPELLAESDVF-----------VLPSYREGLPRSLLEAMAAG-RPVItTDVPGC 298

                         170
                  ....*....|.
gi 1084248262 282 GEIIETGKTGY 292
Cdd:cd03808   299 RELVIDGVNGF 309
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 158-295 3.00e-05

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 45.45  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 158 LYVGRfsqLEQSKGQDVLVKNFiNLIEAGLRGWKLVLAG-----------------ASNVGRTGFVDslikesvnypiti 220
Cdd:cd03798   204 LFVGR---LIPRKGIDLLLEAF-ARLAKARPDVVLLIVGdgplrealralaedlglGDRVTFTGRLP------------- 266

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084248262 221 ienaaFREIVKLYSKAKIFwsaagygvdekSTPEKMEHFGISVVEAMASGaVPII-YDGGGHGEIIETGKTGYTWR 295
Cdd:cd03798   267 -----HEQVPAYYRACDVF-----------VLPSRHEGFGLVLLEAMACG-LPVVaTDVGGIPEVVGDPETGLLVP 325
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 141-331 4.40e-05

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 44.60  E-value: 4.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 141 PPVDIDKLKAGRKENMLLYVGRFSQleqSKGQDVLVKNFINLIEAgLRGWKLVLAGasnvgrTGFVDSLIKESVNypITI 220
Cdd:cd04949   147 DQLDTAESNHERKSNKIITISRLAP---EKQLDHLIEAVAKAVKK-VPEITLDIYG------YGEEREKLKKLIE--ELH 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 221 IENAAF-----REIVKLYSKAKIFWSAAgygvdekstpeKMEHFGISVVEAMASGAVPIIYDGG-GHGEIIETGKTGY-- 292
Cdd:cd04949   215 LEDNVFlkgyhSNLDQEYQDAYLSLLTS-----------QMEGFGLTLMEAIGHGLPVVSYDVKyGPSELIEDGENGYli 283

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1084248262 293 TWRKEKELLTTTLELTENKKRLGELAMHSIEASQKYSYE 331
Cdd:cd04949   284 EKNNIDALADKIIELLNDPEKLQQFSEESYKIAEKYSTE 322
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 253-292 1.17e-03

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 40.36  E-value: 1.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1084248262 253 PEKMEHFGISVVEAMASGaVPII-YDGGGHGEIIETGKTGY 292
Cdd:cd03814   274 PSRTETFGLVVLEAMASG-LPVVaADAGGPRDIVRPGGTGA 313
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 227-293 1.39e-03

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 40.01  E-value: 1.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1084248262 227 REIVKLYSKAKIFWSaagygvdekstPEKMEHFGISVVEAMASGaVPII-YDGGGHGEIIETGKTGYT 293
Cdd:cd03825   255 EQLVDIYSAADLFVH-----------PSLADNLPNTLLEAMACG-TPVVaFDTGGSPEIVQHGVTGYL 310
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 253-292 2.84e-03

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 39.26  E-value: 2.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1084248262 253 PEKMEHFGISVVEAMASGAVPIIYDGGGHGEIIETGKTGY 292
Cdd:cd04962   276 PSEKESFGLAALEAMACGVPVVSSNAGGIPEVVKHGETGF 315
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 133-292 4.89e-03

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 38.45  E-value: 4.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 133 PKKSIVVYPPVDIDKLKAG-------RKENML-------LYVGRFSQLeqsKGQDVLVKNFINLIEAGLRgWKLVLagas 198
Cdd:cd03807   155 KNKIVVIYNGIDLFKLSPDdasraraRRRLGLaedrrviGIVGRLHPV---KDHSDLLRAAALLVETHPD-LRLLL---- 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084248262 199 nVGRTGFVDSLIKESVNYPITiiENAAFR----EIVKLYSKAKIFWSAAGYgvdekstpekmEHFGISVVEAMASGaVPI 274
Cdd:cd03807   227 -VGRGPERPNLERLLLELGLE--DRVHLLgersDVPALLPAMDIFVLSSRT-----------EGFPNALLEAMACG-LPV 291

                         170
                  ....*....|....*....
gi 1084248262 275 IY-DGGGHGEIIEtGKTGY 292
Cdd:cd03807   292 VAtDVGGAAELVD-DGTGF 309
PLN00142 PLN00142
sucrose synthase
 257-292 9.93e-03

sucrose synthase


Pssm-ID: 215073 [Multi-domain]  Cd Length: 815  Bit Score: 37.65  E-value: 9.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1084248262 257 EHFGISVVEAMASGAVPIIYDGGGHGEIIETGKTGY 292
Cdd:PLN00142  677 EAFGLTVVEAMTCGLPTFATCQGGPAEIIVDGVSGF 712
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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