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Conserved domains on  [gi|1084213815|gb|OGM04880|]
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hypothetical protein A2112_01450 [Candidatus Woesebacteria bacterium GWA1_42_12]

Protein Classification

MFS transporter( domain architecture ID 12947616)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 14-404 2.63e-40

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 147.76  E-value: 2.63e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  14 FVYLWISQILSQLTINLTNFLLLIRLFSETGSSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLMITNFFQALVIFS 93
Cdd:cd06173     1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  94 YGVLSGSGVF---LLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNT 170
Cdd:cd06173    81 LALLALLGSLslwLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 171 LFIAALLLFAAFVSVTFLPKLKPSEELPASLEKglldfFGRIIEGYNFIKENRKVLAPFILLLSCQIAMWVAVVNMPALL 250
Cdd:cd06173   161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLL-----LRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 251 LSILGISvSTGIVFAATSSGLGAITSSIFVSKLLRAKTRKKKIIdTSFMVLTFSLFLLGFLVPefegvlrLFIAFPLFFM 330
Cdd:cd06173   236 KEVLGGG-AAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL-IGALLLGLALLVLGLSPS-------LWLLLAALFL 306

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084213815 331 SGFSFVGIIVPAITFLQASTPGGFRGRVFGNFWFLSTIATLFPIIFSGALSELFGVKFLIFILASFTLGAFLVS 404
Cdd:cd06173   307 LGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 14-404 2.63e-40

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 147.76  E-value: 2.63e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  14 FVYLWISQILSQLTINLTNFLLLIRLFSETGSSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLMITNFFQALVIFS 93
Cdd:cd06173     1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  94 YGVLSGSGVF---LLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNT 170
Cdd:cd06173    81 LALLALLGSLslwLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 171 LFIAALLLFAAFVSVTFLPKLKPSEELPASLEKglldfFGRIIEGYNFIKENRKVLAPFILLLSCQIAMWVAVVNMPALL 250
Cdd:cd06173   161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLL-----LRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 251 LSILGISvSTGIVFAATSSGLGAITSSIFVSKLLRAKTRKKKIIdTSFMVLTFSLFLLGFLVPefegvlrLFIAFPLFFM 330
Cdd:cd06173   236 KEVLGGG-AAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL-IGALLLGLALLVLGLSPS-------LWLLLAALFL 306

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084213815 331 SGFSFVGIIVPAITFLQASTPGGFRGRVFGNFWFLSTIATLFPIIFSGALSELFGVKFLIFILASFTLGAFLVS 404
Cdd:cd06173   307 LGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
2A0121 TIGR00900
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
 14-385 1.02e-24

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162098 [Multi-domain]  Cd Length: 365  Bit Score: 104.32  E-value: 1.02e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  14 FVYLWISQILSQLTINLTNFLLLIRLFSETGSSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLMIT---NFFQALV 90
Cdd:TIGR00900   1 FRLLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGAdliRAVLVAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  91 IFSYGVLSGSGVFLLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNT 170
Cdd:TIGR00900  81 LPFVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 171 LFIAALLLF--AAFVSVTFLPKLKPSEELPASLekgllDFFGRIIEGYNFIKENRKVlapFILLLSCQIAMWVAVVNMPA 248
Cdd:TIGR00900 161 IWVDAVGFAisALLIVSVRIPELAASEIQALSN-----AVLRDTREGIKFVLKNPLL---RTLLLLALLFNLVFAPAIVA 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 249 LLLSILGISVSTGIV---FAATSSGLGAITSSIFVSKLLRAKTRKKKIIdTSFMVLTFSLFLLGFLVPEFEGVLrlfiaf 325
Cdd:TIGR00900 233 LFPYVQSKYLGRGSThygWVLAAFGLGALLGALLLGLLGRYFKRMALMT-GAIFVIGLAILVVGLTPPNFPLFL------ 305

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 326 PLFFMSGFSFVGIIVPAITFLQASTPGGFRGRVFGNFWFLSTIATLFPIIFSGALSELFG 385
Cdd:TIGR00900 306 VLWFAIGVGYGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLADHLG 365
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-360 3.06e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 67.31  E-value: 3.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  14 FVYLWISQILSQLTINLTNFLLLIRLFSETGSSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLMITNFFQALVIFS 93
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  94 YGVLSGSGVFLLYGVAVAysLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFI 173
Cdd:COG2814    92 CALAPSLWLLLAARFLQG--LGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 174 AALLLFAAFVSVTFLPKlKPSEELPASLEKGLLDFFGRiiegynfikenRKVLAPFILLLSCQIAMWVAVVNMPALLLSI 253
Cdd:COG2814   170 NAVLALLALLLLLRLLP-ESRPAARARLRGSLRELLRR-----------PRLLLLLLLAFLLGFGFFALFTYLPLYLQEV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 254 LGISVSTgIVFAATSSGLGAITSSIFVSKLLRaKTRKKKIIDTSFMVLTFSLFLLGFLVPefegvlrLFIAFPLFFMSGF 333
Cdd:COG2814   238 LGLSASA-AGLLLALFGLGGVLGALLAGRLAD-RFGRRRLLLIGLLLLALGLLLLALAGS-------LWLLLLALFLLGF 308

                         330       340
                  ....*....|....*....|....*..
gi 1084213815 334 SFVGIIVPAITFLQASTPGGFRGRVFG 360
Cdd:COG2814   309 GFGLLFPLLQALVAELAPPEARGRASG 335
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 5-404 2.43e-10

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 62.63  E-value: 2.43e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815    5 FKPVIKNKKFVYLWISQILSQLTINLTNFLL---LIRLFSETGSSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLM 81
Cdd:PRK08633     2 MKNLLKIIGFLPLLLTQFLNAFNDLGHKILIqntLIKAYDGSEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815   82 ITNFFQ----ALVIFSYGvlsgSGVF-LLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFI 156
Cdd:PRK08633    82 IVKLFEvgltLLIVLAYY----LGWFwLAFAVTFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAFTIVAILAGTA 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  157 AAGILSHFLGFSNTLFIAALLLFAAFVSVTF----------LPKLKPSEelPASLEKGLLDFFGRIIEGYNFIKENRkvl 226
Cdd:PRK08633   158 LFSFLFESVNGNTPSEILGRIAPAGLVLLAVavlglifayrLPKVPAAA--PEVFDKKKYLFPKLLWRNLKLLRSDR--- 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  227 apFILLLSCQIAM-W----VAVVNMPALLLSILGIS--VSTGIVFAAtsSGLGAITSSIFVSKLlraktrKKKIIDTSF- 298
Cdd:PRK08633   233 --VLWLAIIGLSYfWfisqLAQANFPAYAKEVLGLDntFQVQYLLAA--SAIGIGIGSLLAGRL------SGRHIELGLv 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  299 ----MVLTFSLFLLGFlVPEFEGVLRLFIAFplffmsGFSFVGIIVPAITFLQASTPGGFRGRVFGNFWFLSTIATLFPI 374
Cdd:PRK08633   303 plgaLGLALSLFLLPT-APSLASVLVLFFLF------GFSAGLFIVPLNALIQFRAPEKELGKVLAANNFLQNVGMLLFL 375

                          410       420       430
                   ....*....|....*....|....*....|.
gi 1084213815  375 IFSGALSEL-FGVKFLIFILASFTLGAFLVS 404
Cdd:PRK08633   376 ALTTLFSGLgLSPAGLFYLIALVTLIGTLYT 406
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 9-357 5.20e-10

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 61.30  E-value: 5.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815   9 IKNKKFVYLWISQILSQLTINLTNFLLLIRLFSETGSSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLMITNFFQA 88
Cdd:pfam05977   7 LRQGVFRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  89 LVIFSYGVLSGSG---VFLLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFL 165
Cdd:pfam05977  87 LVSTLLTLLAGLGllsPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAF 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 166 GFSNTLFIAALLLFAAFVSVTFLPKLKPSEELPASlekgllDFFGRIIEGYNFIK---ENRKVLAPFILLLSCQIAMWVA 242
Cdd:pfam05977 167 GPAFTFALNALSYFAVIAALWRWKRAAPASPLPRE------RIFGAVRAGLRFTAmsrELRSVLVRAFAFGLSASAVWAL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 243 vvnMPALLLSILGISVST-GIVFAATssGLGAITSSIFVSKlLRAKTRKKKIIDTSFMVLTFSLFLLGFLVPefegvlrL 321
Cdd:pfam05977 241 ---LPLVARDLLDGDAIFyGILLGAV--GVGAILGALSLPR-LRERLGSDRLVLLASVVTALVLLSLALAPN-------L 307

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1084213815 322 FIAFPLFFMSGFSFVGIIVPAITFLQASTPGGFRGR 357
Cdd:pfam05977 308 WLAIPVLLLGGAAWITALTTLNVAVQLSVPRWVRGR 343
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 14-404 2.63e-40

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 147.76  E-value: 2.63e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  14 FVYLWISQILSQLTINLTNFLLLIRLFSETGSSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLMITNFFQALVIFS 93
Cdd:cd06173     1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  94 YGVLSGSGVF---LLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNT 170
Cdd:cd06173    81 LALLALLGSLslwLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 171 LFIAALLLFAAFVSVTFLPKLKPSEELPASLEKglldfFGRIIEGYNFIKENRKVLAPFILLLSCQIAMWVAVVNMPALL 250
Cdd:cd06173   161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLL-----LRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 251 LSILGISvSTGIVFAATSSGLGAITSSIFVSKLLRAKTRKKKIIdTSFMVLTFSLFLLGFLVPefegvlrLFIAFPLFFM 330
Cdd:cd06173   236 KEVLGGG-AAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL-IGALLLGLALLVLGLSPS-------LWLLLAALFL 306

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084213815 331 SGFSFVGIIVPAITFLQASTPGGFRGRVFGNFWFLSTIATLFPIIFSGALSELFGVKFLIFILASFTLGAFLVS 404
Cdd:cd06173   307 LGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
2A0121 TIGR00900
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
 14-385 1.02e-24

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162098 [Multi-domain]  Cd Length: 365  Bit Score: 104.32  E-value: 1.02e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  14 FVYLWISQILSQLTINLTNFLLLIRLFSETGSSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLMIT---NFFQALV 90
Cdd:TIGR00900   1 FRLLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGAdliRAVLVAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  91 IFSYGVLSGSGVFLLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNT 170
Cdd:TIGR00900  81 LPFVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 171 LFIAALLLF--AAFVSVTFLPKLKPSEELPASLekgllDFFGRIIEGYNFIKENRKVlapFILLLSCQIAMWVAVVNMPA 248
Cdd:TIGR00900 161 IWVDAVGFAisALLIVSVRIPELAASEIQALSN-----AVLRDTREGIKFVLKNPLL---RTLLLLALLFNLVFAPAIVA 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 249 LLLSILGISVSTGIV---FAATSSGLGAITSSIFVSKLLRAKTRKKKIIdTSFMVLTFSLFLLGFLVPEFEGVLrlfiaf 325
Cdd:TIGR00900 233 LFPYVQSKYLGRGSThygWVLAAFGLGALLGALLLGLLGRYFKRMALMT-GAIFVIGLAILVVGLTPPNFPLFL------ 305

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 326 PLFFMSGFSFVGIIVPAITFLQASTPGGFRGRVFGNFWFLSTIATLFPIIFSGALSELFG 385
Cdd:TIGR00900 306 VLWFAIGVGYGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLADHLG 365
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-360 3.06e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 67.31  E-value: 3.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  14 FVYLWISQILSQLTINLTNFLLLIRLFSETGSSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLMITNFFQALVIFS 93
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  94 YGVLSGSGVFLLYGVAVAysLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFI 173
Cdd:COG2814    92 CALAPSLWLLLAARFLQG--LGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 174 AALLLFAAFVSVTFLPKlKPSEELPASLEKGLLDFFGRiiegynfikenRKVLAPFILLLSCQIAMWVAVVNMPALLLSI 253
Cdd:COG2814   170 NAVLALLALLLLLRLLP-ESRPAARARLRGSLRELLRR-----------PRLLLLLLLAFLLGFGFFALFTYLPLYLQEV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 254 LGISVSTgIVFAATSSGLGAITSSIFVSKLLRaKTRKKKIIDTSFMVLTFSLFLLGFLVPefegvlrLFIAFPLFFMSGF 333
Cdd:COG2814   238 LGLSASA-AGLLLALFGLGGVLGALLAGRLAD-RFGRRRLLLIGLLLLALGLLLLALAGS-------LWLLLLALFLLGF 308

                         330       340
                  ....*....|....*....|....*..
gi 1084213815 334 SFVGIIVPAITFLQASTPGGFRGRVFG 360
Cdd:COG2814   309 GFGLLFPLLQALVAELAPPEARGRASG 335
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 5-404 2.43e-10

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 62.63  E-value: 2.43e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815    5 FKPVIKNKKFVYLWISQILSQLTINLTNFLL---LIRLFSETGSSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLM 81
Cdd:PRK08633     2 MKNLLKIIGFLPLLLTQFLNAFNDLGHKILIqntLIKAYDGSEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815   82 ITNFFQ----ALVIFSYGvlsgSGVF-LLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFI 156
Cdd:PRK08633    82 IVKLFEvgltLLIVLAYY----LGWFwLAFAVTFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAFTIVAILAGTA 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  157 AAGILSHFLGFSNTLFIAALLLFAAFVSVTF----------LPKLKPSEelPASLEKGLLDFFGRIIEGYNFIKENRkvl 226
Cdd:PRK08633   158 LFSFLFESVNGNTPSEILGRIAPAGLVLLAVavlglifayrLPKVPAAA--PEVFDKKKYLFPKLLWRNLKLLRSDR--- 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  227 apFILLLSCQIAM-W----VAVVNMPALLLSILGIS--VSTGIVFAAtsSGLGAITSSIFVSKLlraktrKKKIIDTSF- 298
Cdd:PRK08633   233 --VLWLAIIGLSYfWfisqLAQANFPAYAKEVLGLDntFQVQYLLAA--SAIGIGIGSLLAGRL------SGRHIELGLv 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  299 ----MVLTFSLFLLGFlVPEFEGVLRLFIAFplffmsGFSFVGIIVPAITFLQASTPGGFRGRVFGNFWFLSTIATLFPI 374
Cdd:PRK08633   303 plgaLGLALSLFLLPT-APSLASVLVLFFLF------GFSAGLFIVPLNALIQFRAPEKELGKVLAANNFLQNVGMLLFL 375

                          410       420       430
                   ....*....|....*....|....*....|.
gi 1084213815  375 IFSGALSEL-FGVKFLIFILASFTLGAFLVS 404
Cdd:PRK08633   376 ALTTLFSGLgLSPAGLFYLIALVTLIGTLYT 406
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 9-357 5.20e-10

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 61.30  E-value: 5.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815   9 IKNKKFVYLWISQILSQLTINLTNFLLLIRLFSETGSSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLMITNFFQA 88
Cdd:pfam05977   7 LRQGVFRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  89 LVIFSYGVLSGSG---VFLLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFL 165
Cdd:pfam05977  87 LVSTLLTLLAGLGllsPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAF 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 166 GFSNTLFIAALLLFAAFVSVTFLPKLKPSEELPASlekgllDFFGRIIEGYNFIK---ENRKVLAPFILLLSCQIAMWVA 242
Cdd:pfam05977 167 GPAFTFALNALSYFAVIAALWRWKRAAPASPLPRE------RIFGAVRAGLRFTAmsrELRSVLVRAFAFGLSASAVWAL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 243 vvnMPALLLSILGISVST-GIVFAATssGLGAITSSIFVSKlLRAKTRKKKIIDTSFMVLTFSLFLLGFLVPefegvlrL 321
Cdd:pfam05977 241 ---LPLVARDLLDGDAIFyGILLGAV--GVGAILGALSLPR-LRERLGSDRLVLLASVVTALVLLSLALAPN-------L 307

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1084213815 322 FIAFPLFFMSGFSFVGIIVPAITFLQASTPGGFRGR 357
Cdd:pfam05977 308 WLAIPVLLLGGAAWITALTTLNVAVQLSVPRWVRGR 343
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 17-403 6.13e-10

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 60.32  E-value: 6.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  17 LWISQILSQLTINLTNFLLLIRLFSETG-SSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLMITNFFQALVIFSYG 95
Cdd:cd17329     4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGlSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  96 VLSGSGVFLLygVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAA 175
Cdd:cd17329    84 FAHSPWLFAI--ALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 176 LLLFAAFVSVTFLPKLKPSEELPASLEkglldffgrIIEGYNFIKENRKVLAPFILLLSCQIAMWVAVVNMPALLLSILG 255
Cdd:cd17329   162 LFLLAALVLLFLLPETRPKRRAAEKTE---------ILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 256 ISVST-GIVFAAtsSGLGAITSSIFVSKLLRAKTRKKkiidtsFMVLTFSLFLLGFLVPEFEGVLRLFIAFPLFFMSGFS 334
Cdd:cd17329   233 LGESLlGLLLAL--NALLIVLLQFPVARLVERFRLRK------ILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEM 304

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1084213815 335 FVGIIVPAITFlqASTPGGFRGRVFGNFWFLSTIATLFPIIFSGALSELFGVKFLIFILASFTLGAFLV 403
Cdd:cd17329   305 LVFPAVQTLVA--ALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
MFS_1 pfam07690
Major Facilitator Superfamily;
17-372 1.14e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 59.35  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  17 LWISQILSQLTINLTNFLLLIRLFSETGSSIAT-SLLWICYALPAIVIGPFASASVDMVDRRLLLMITNFFQAlvIFSYG 95
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEiGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFA--LGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  96 VLSGSGVFLLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAA 175
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 176 LLLFAAFVSVTFLPKLKPSEELPASLEKGLLDFFGRIIEGynfikenRKVLAPFILLLSCQIAMWVAVVNMPALLLSILG 255
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALL-------RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 256 ISVSTGIVFAATSSGLGAITSSIFVSKLLRAKTRKKKIIDTSFMVLTFSLFLLgflvpeFEGVLRLFIAFPLFFMSGFSF 335
Cdd:pfam07690 232 LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL------LSLTLSSLWLLLALLLLGFGF 305

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1084213815 336 VGIIVPAITFLQASTPGGFRGRVFGNFWFLSTIATLF 372
Cdd:pfam07690 306 GLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 44-403 9.17e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.82  E-value: 9.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  44 GSSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLMITNFFQALVIFSYGVlsGSGVFLLYGVAVAYSLLNQFYVPAE 123
Cdd:cd17325    28 ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF--ATSYWQLLLARFLQGLASAAVWPAA 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 124 AASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAALLLFAAFVSVTFLpkLKPSEELPASLEK 203
Cdd:cd17325   106 MALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLL--LPEPRPPPNKRAV 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 204 GLLDFFGRIIEgynfIKENRKVLAPFILLLSCQIAMWVAVVNMPALLLSILGISVST-GIVFAAtsSGLGAITSSIFVSK 282
Cdd:cd17325   184 SAARLRSGLRL----LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQiGLLFGA--QGLASALSQPPAGK 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 283 LLRAKTRKKKIIdTSFMVLTFSLFLLGFlvpefegVLRLFIAFPLFFMSGFSFVGIIVPAITFLQASTPGGFRGRVFGNF 362
Cdd:cd17325   258 LSDRIGRKPLIL-IGLLLSAVALLLLPL-------ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLF 329

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1084213815 363 WFLSTIATLFPIIFSGALSELFGVKFLIFILASFTLGAFLV 403
Cdd:cd17325   330 NTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVL 370
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
5-396 2.97e-06

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 49.58  E-value: 2.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815    5 FKPVIKNKKFVYLWISQILSQLTIN-LTNFLLLIRLFSETGSSIATSLLWICYALpAIVIGPF------ASASVDMVDRR 77
Cdd:PRK06814     4 KLYLMKSRRFAPLFWTQFFGAFNDNfLKNALVILILYGLSGALGAYNNALVTLAG-AVFILPFfifsalAGQLADKYDKA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815   78 LLLMITNFFQ--ALVIFSYGVLSGSgVFLLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGF 155
Cdd:PRK06814    83 KLAKILKFAEigIAALAIYGFHLNS-VPLLFAALFLMGIHSALFGPIKYSILPDHLNKDELLGANALVEAGTFIAILLGT 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  156 IAAGILSHFLGFSNTLFIAALLLFAAFVSVTFLPKLKPSeelpaslEKGLldffgRIieGYNFIKENRKVLAPFI----L 231
Cdd:PRK06814   162 IIGGLATISGNFVILVALLMGIAVLGWLASLFIPKTGNA-------APDL-----KI--DRNIIRSTITLLKYAKadkrI 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  232 LLSCQIAMWV----AVV----------------NMPALLLSILGISVSTGIVFAATSSG---------LGAITSSIFvsk 282
Cdd:PRK06814   228 WLAILGISWFwlvgAVVlsqlpllaketlggdeNVATLFLAVFSVGVAVGSFLASKLSEgritllyvpIGALLMGLF--- 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  283 llraktrkkkIIDTSFMVLTFS------LFLLGFLvpEFEGVLRlfIAFPLFFMSGFSFVgIIVPAITFLQASTPGGFRG 356
Cdd:PRK06814   305 ----------GLDLAFASSSVPaepaqlKSILVFL--SKRHGWR--ILIDLFGLAAAGGL-YIVPLFAALQAWANPAHRA 369

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1084213815  357 RVFGNFWFLSTIatlFPIIFSGALSELFGVKFLIFILASF 396
Cdd:PRK06814   370 RVIAANNVLNAA---FMVAGTIILALLQALGFSIPWIILF 406
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 125-404 3.93e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 48.75  E-value: 3.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 125 ASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAALLLFAAFVSVTFLpkLKPSEELPASLEKG 204
Cdd:cd17472   106 ALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFF--VPDPPKIVQISEKE 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 205 LLDFFGRIIEgynfiKENRKVLAPFILLLSCQIAMWVAVvnmPALLLSILGISVSTGIVFAATSsgLGAITSSIFVSKLL 284
Cdd:cd17472   184 KKKLKKLLKN-----KRLLRLDFSIFILHFVLMAFFYIL---PLLLTQLGGGKGQLWKVYLPAI--LIGFILMVPFVIYA 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 285 RAKTRKKKIIDTSFMVLTFSLFLLGFLVPEFEgvlrLFIAFPLFFMSGFSFVGIIVPAITFLQAstPGGFRGRVFGNFWF 364
Cdd:cd17472   254 EKKGKMKQVFVSSILLIAVGFLLLLFAATSLW----LLIIGLIIFFIGFNLLEALLPSLVSKIA--PKEYRGTAMGIYNT 327

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1084213815 365 LSTIATLFPIIFSGALSELFGVKFLIFILASFTLGAFLVS 404
Cdd:cd17472   328 SQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVS 367
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 17-404 9.22e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.42  E-value: 9.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  17 LWISQILSQLTINLTNFLLLIRLFSETGSSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLMITNFFQALVIFSYGV 96
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  97 LSGsgVFLLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAAL 176
Cdd:cd06174    81 APS--FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 177 LLFAAFVSVTFLpkLKPSEELPASLEKGLLDFFGRIIEGYNFIKENRKVLAPFILLLSCQIAMWVAVVNMPALLLSILGI 256
Cdd:cd06174   159 AALALLAAILLL--LVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 257 SVSTGIVFAATSSGLGAITSSIFVSKLLRAKTRKKKIIDTSFMVLTFSLFLLGFLVPefegvlrlFIAFPLFFMSGFSFV 336
Cdd:cd06174   237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSL--------LLLLLLLLLLGFGLG 308

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1084213815 337 GIIVPAITFLQASTPGGFRGRVFG-NFWFLSTIATLFPIIFSGALSELFGVKFLIFILASFTLGAFLVS 404
Cdd:cd06174   309 GLLPLSFALIAELFPPEIRGTAFGlLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 129-407 3.98e-05

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 45.29  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 129 SLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAALLLFAAFVSVTFLPKLKPSEELPASLEKGLLDF 208
Cdd:cd17490   111 SYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKELLSV 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 209 FGriiegynfikeNRKVLAPFILLLSCQIAMWVAVVNMPALLLSILGISVSTGIVFAATSSGLGAITSSIFVSKLLRaKT 288
Cdd:cd17490   191 LK-----------DKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYK-KL 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 289 RKKKIIDTSFMVLTFSLFLLGFlvpefegVLRLFIAFPLFFMSGFSFvGIIVPAITFLQ-ASTPGGFRGRVFGNFWFLST 367
Cdd:cd17490   259 GERNTIIIGFLLLGAYCFLIPF-------APNLTLLYLLQALNGFGT-GILFPLLMSLSiEGVPAEQRSTAMGFFQAIYA 330

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1084213815 368 IATLFPIIFSGALSELFGVKFLIFILASFTLGAFLVSKNY 407
Cdd:cd17490   331 LGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAY 370
PRK10489 PRK10489
enterobactin transporter EntS;
102-360 4.80e-05

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 45.35  E-value: 4.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 102 VFLLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAALLLFAA 181
Cdd:PRK10489  110 LLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIAAGGVAWNYGLAAAGTFIT 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 182 FVSVTFLPKLKPSEELPASLEKGLLDffgriieGYNFIKENRKVLApfILLLSCQIAMWVAV-VNMPALLLSILGISVS- 259
Cdd:PRK10489  190 LLPLLRLPALPPPPQPREHPLRSLLA-------GFRFLLASPVVGG--IALLGGLLTMASAVrVLYPALADEVWQMGAAq 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 260 TGIVFAATSSG--LGAITSSIFvskllrAKTRKKKIIDTSFMVLTFSLFLLGFLVPefegvlrlFIAFPLFFMSGFSFVG 337
Cdd:PRK10489  261 IGLLYAAVPLGaaLGALTSGWL------AHSARPGLLMLLSTLGSFLAVGLFGLMP--------MWILAVLCLALFGYLS 326

                         250       260
                  ....*....|....*....|....*
gi 1084213815 338 IIVPAI--TFLQASTPGGFRGRVFG 360
Cdd:PRK10489  327 AISSLLqyTLLQTQTPDEMLGRING 351
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 56-334 1.46e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.69  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  56 YALPAIVIGPFASASVDMVDRRLLLMITNFFQALVIFSYGVLSGSGVFLLYGVAVAysLLNQFYVPAEAASLPSLVDKEN 135
Cdd:cd17324    43 YALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAG--LAHGGFWAIAAAYAADLVPPEK 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 136 LPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAALLLFAAFVSVTF-LPKLKPSEELPASLEKGLLDFFGriie 214
Cdd:cd17324   121 RGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRlLPSLPPKKPGSLGLLSSLLLLLR---- 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 215 gynfikenRKVLAPFILLLSCQIAMWVAVVNMPALLLSILGISVSTGIVFAATSSGLGAITSSIFVSKLlrAKTRKKKII 294
Cdd:cd17324   197 --------NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRL--ADRGGRRAL 266

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1084213815 295 DTSFMVLTFSLFLLGFLVPEFEGVLRLFIAFPLFFMSGFS 334
Cdd:cd17324   267 LIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHS 306
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 17-403 1.54e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 43.74  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  17 LWISQILSQLTINLTNFLLLIRLFSETGSSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLMITNFFQALVIFSYGV 96
Cdd:cd17489     1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  97 lsGSGVFLLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAAL 176
Cdd:cd17489    81 --ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 177 LLFAAFVSVTFLPKLKPSeelPASLEKGLLDFFGRIIEgynfikenRKVLAPFILLLSCQIAMwVAVVNMPALLLSILGI 256
Cdd:cd17489   159 LALLALLLVFLVKDPPPV---AAEEAEAGTRAFRRLVE--------KKVLPPALILFLASIAY-GAISTFLPLYAAERGI 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 257 SVsTGIVFAAtsSGLGAITSSIFVSKLLRAKTRKKkiidtsFMVLTFSLFLLGFLVPEFEGVLRLFIAFPLFFMSGFsfv 336
Cdd:cd17489   227 SN-AGLFFTV--YAIALLLSRPFSGKLSDRKGPKT------VIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGF--- 294

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1084213815 337 GIIVPAITFLQ-ASTPGGFRGRVFGNFWFLSTIATLFPIIFSGALSELFGVKFLIFILASFTLGAFLV 403
Cdd:cd17489   295 GLLFPALQALAvDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 45-188 1.97e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 43.33  E-value: 1.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  45 SSIATSLLWICYALPAIVIGPFASASVDMVDRRLLLMITNFFQALVIFSYGVLSGsgVFLLYGVAVAYSLLNQFYVPAEA 124
Cdd:cd17325   233 SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS--FWLLLLLLALLGLGLGLVFPATL 310

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084213815 125 ASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAALLLFAAFVSVTFL 188
Cdd:cd17325   311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
2_A_01_02 TIGR00880
Multidrug resistance protein;
50-190 3.86e-04

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 40.33  E-value: 3.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  50 SLLWICYALPAIVIGPFASASVDMVDRRLLLMITNFFQalVIFSYGVLSGSGVFLLYGVAVAYSLLNQFYVPAEAASLPS 129
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIF--VLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIAD 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1084213815 130 LVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAALLLFAAFVSVTFLPK 190
Cdd:TIGR00880  79 IYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
40-404 2.87e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.47  E-value: 2.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  40 FSETGSSIATSLLWICYALPAIVIGPFAsasvDMVDRRLLLMITNFFQALVIFSYGVLSGSGVFL----LYGVAVAysll 115
Cdd:COG2271    42 LSAAQLGLLASAFFLGYALGQIPAGLLA----DRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLllrfLLGLGEA---- 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 116 nqFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAALLLFAAFVSvtflpklkpse 195
Cdd:COG2271   114 --GFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL----------- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 196 elpaslekglldffgriiegynfikenrKVLAPFILLLSCQIAMWVAVVNMPALLLSILGISVSTgIVFAATSSGLGAIT 275
Cdd:COG2271   181 ----------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQ-AGLLLSLPFLAGIV 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 276 SSIFVSKLLRAKTRKKKIIDTSFMVLTFSLFLLGFLVPEfegvlrLFIAFPLFFMSGFSFVGIIVPAITFLQASTPGGFR 355
Cdd:COG2271   232 GSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPS------PALAIALLFLAGFGLGGAFGLLWALAAELFPKKAR 305

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1084213815 356 GRVFGNFWFLSTIATLFPIIFSGALSELFGVKFLIFILASFTLGAFLVS 404
Cdd:COG2271   306 GTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
14-190 2.90e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.47  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  14 FVYLWISQILSQLTINLTNFLLLIRLFSETGSSIATSLLW-ICYALPAIVIGPFASASVDMVDRRLLLMITNFFQALVIF 92
Cdd:COG2271   182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLlSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  93 SYGVLSGSGVFLLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLF 172
Cdd:COG2271   262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341

                         170
                  ....*....|....*...
gi 1084213815 173 IAALLLFAAFVSVTFLPK 190
Cdd:COG2271   342 LLAALALLAALLALLLLR 359
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
40-404 4.39e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.09  E-value: 4.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  40 FSETGSSIATSLLWICYALPAIVIGPFasasVDMVDRRLLLMITNFFQALVIFSYGVLSGSGVFLLYGVAVAYSLLNQFY 119
Cdd:COG2223    37 LSAAQLGLLFAIPVLVGALLRIPLGFL----VDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 120 VPaeAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAALLLFAAFVSVTFLpkLKPSEELPA 199
Cdd:COG2223   113 VG--IALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLF--LRDPPAGAA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 200 SLEKGLLDFFGRIIegynfikENRKVLAPFILLLSCQIAMWVAVVNMPALLLSILGISVSTGIVFAATSSGLGAITSsiF 279
Cdd:COG2223   189 AAAKASLRDQLEAL-------RDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGR--P 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 280 VSKLLRAKTRKKKIIDTSFMVLTFSLFLLGFLVPEFEGVLRLFIAFPLFFMSGFSFVGIIVPAItflqasTPGGFRGRVF 359
Cdd:COG2223   260 LGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDI------FPTKNAGAVY 333

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1084213815 360 GNFWFLSTIATLFPIIFSGALSELFGVKFLIF-ILASFTLGAFLVS 404
Cdd:COG2223   334 GLVGAAGGLGGFLGPLLFGALLDATGSYTAAFlVFAVLALVALVLT 379
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 54-188 5.10e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 38.73  E-value: 5.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  54 ICYALPAIVIGPFASASVDMVDRRLLLMITNFFQALVIFSYGVlsGSGVFLLYGVAVAYSLLNQFYVPAEAASLPSLVDK 133
Cdd:cd17489   234 TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF--AGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPP 311

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1084213815 134 ENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAALLLFAAFVSVTFL 188
Cdd:cd17489   312 HRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-189 7.92e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 38.34  E-value: 7.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815   1 MLGEFKPVIKNKKFVYLWISQILSQLTINLTNFLLLIRLFSETGSSIA-TSLLWICYALPAIVIGPFASASVDMVDRRLL 79
Cdd:COG2211   217 LKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAAlVGLLLALYFLAALLGAPLWPRLAKRFGKKKA 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815  80 LMITNFFQALVIFSYGVLSGSGVFLLYGVAVAYSLLNQFYVPAEAASLPSLVDKENLPQ-------ANSLFLLTQQASVM 152
Cdd:COG2211   297 FIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQA 376

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1084213815 153 VGFIAAGILSHFLGFSNTLFIAALLLFAAFVSVTFLP 189
Cdd:COG2211   377 LAGALAGLLLALFGYVAGAAQSPSALTGIRLLFFLLP 413
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 119-405 8.63e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 38.01  E-value: 8.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 119 YVPAEAASLPSLVDKENLPQANSLFLLTQQASVMVGFIAAGILSHFLGFSNTLFIAALLLFAAFVSVTFLPKlkpSEELP 198
Cdd:cd17391   105 YVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVK---EDFKP 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 199 ASLEKGLldffgRIIEGYNFIKENRKVLAPFILLLSCQIAMwVAVVNMPALLLSILGISVS-----TGIVFAATssGLGA 273
Cdd:cd17391   182 VEKKKMV-----STKEVWNSVPNPSLLISLFVTTFIIQLAN-QSIEPILTLYIRQLMGDASnlafiSGLVFSAT--GVSS 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084213815 274 ITSSIFVSKLLRAKTRKKKIIDTSFMVltfslFLLGFLVPEFEGVLRLFIafpLFFMSGFSfVGIIVPAI-TFLQASTPG 352
Cdd:cd17391   254 LLSAPRLGKLGDRIGHHRILLGALLAS-----ALLYIPQAFVQTPWQLGI---LRFLLGLA-TGGLLPAInSLLAKITPK 324

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1084213815 353 GFRGRVFGNFWFLSTIATLFPIIFSGALSELFGVKFLIFILASFTLGAFLVSK 405
Cdd:cd17391   325 EVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSF 377
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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