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Conserved domains on  [gi|1081349916|gb|OFU88100|]
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DNA topology modulation protein FlaR [Streptococcus sp. HMSC10E12]

Protein Classification

DNA topology modulation protein( domain architecture ID 10012904)

DNA topology modulation protein contains a Walker A motif, also known as the P-loop or phosphate-binding loop, which is present in many ATP or GTP utilizing proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK07261 PRK07261
DNA topology modulation protein;
1-168 2.53e-114

DNA topology modulation protein;


:

Pssm-ID: 180911 [Multi-domain]  Cd Length: 171  Bit Score: 321.28  E-value: 2.53e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349916   1 MKIAIIGYSGSGKSTLANFLGQHYNCEVLHLDKIHFTSNWQERTVDEMTDDISTFMLQRDWIIEGNYSACLYEERMREAD 80
Cdd:PRK07261    1 MKIAIIGYSGSGKSTLARKLSQHYNCPVLHLDTLHFQPNWQERDDDDMIADISNFLLKHDWIIDGNYSWCLYEERMQEAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349916  81 CIVYFNFNRVNCLYRAFRRYLTYRGKTRPSIAEDCNEKFDFAFVKWILLDGRSKKYVEQYNVVVKNYSDKTIILKNQRQL 160
Cdd:PRK07261   81 QIIFLNFSRFNCLYRAFKRYLKYRGKTRESMAENCPEKFDWEFIKWILLDGRSKKQKENYQSVCQKYSHKTIVLKNQKEL 160


                  ....*...
gi 1081349916 161 NHYMKQVK 168
Cdd:PRK07261  161 DQYLKKIR 168
 
Name Accession Description Interval E-value
PRK07261 PRK07261
DNA topology modulation protein;
1-168 2.53e-114

DNA topology modulation protein;


Pssm-ID: 180911 [Multi-domain]  Cd Length: 171  Bit Score: 321.28  E-value: 2.53e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349916   1 MKIAIIGYSGSGKSTLANFLGQHYNCEVLHLDKIHFTSNWQERTVDEMTDDISTFMLQRDWIIEGNYSACLYEERMREAD 80
Cdd:PRK07261    1 MKIAIIGYSGSGKSTLARKLSQHYNCPVLHLDTLHFQPNWQERDDDDMIADISNFLLKHDWIIDGNYSWCLYEERMQEAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349916  81 CIVYFNFNRVNCLYRAFRRYLTYRGKTRPSIAEDCNEKFDFAFVKWILLDGRSKKYVEQYNVVVKNYSDKTIILKNQRQL 160
Cdd:PRK07261   81 QIIFLNFSRFNCLYRAFKRYLKYRGKTRESMAENCPEKFDWEFIKWILLDGRSKKQKENYQSVCQKYSHKTIVLKNQKEL 160


                  ....*...
gi 1081349916 161 NHYMKQVK 168
Cdd:PRK07261  161 DQYLKKIR 168
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
1-83 2.86e-05

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 42.11  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349916   1 MKIAIIGYSGSGKSTLANFLGQHYNCEVLHLDKI-----HFTSNWQERT-----VDEMTDDISTfMLQRDWIIEGNYSAC 70
Cdd:COG1936     1 MRIAITGTPGTGKTTVAKLLAERLGLEVIHLNDLvkeegLYTEVDEERDslvvdEDALAEELEE-LKEGDVIIEGHLAHL 79

                          90
                  ....*....|...
gi 1081349916  71 LyeermrEADCIV 83
Cdd:COG1936    80 V------DVDRVI 86
AAA_28 pfam13521
AAA domain;
2-30 2.90e-04

AAA domain;


Pssm-ID: 433278 [Multi-domain]  Cd Length: 164  Bit Score: 39.17  E-value: 2.90e-04
                          10        20
                  ....*....|....*....|....*....
gi 1081349916   2 KIAIIGYSGSGKSTLANFLGQHYNCEVLH 30
Cdd:pfam13521   1 RIVITGGPSTGKTTLAEALAARFGYPVVP 29
ABCC_MRP_Like cd03228
ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP ...
 2-24 5.42e-04

ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP (Multidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a diverse functional spectrum that includes ion transport, cell surface receptor, and toxin secretion activities. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains, each composed of six transmembrane (TM) helices, and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213195 [Multi-domain]  Cd Length: 171  Bit Score: 38.52  E-value: 5.42e-04
                          10        20
                  ....*....|....*....|...
gi 1081349916   2 KIAIIGYSGSGKSTLANFLGQHY 24
Cdd:cd03228    30 KVAIVGPSGSGKSTLLKLLLRLY 52
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 2-27 3.70e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.20  E-value: 3.70e-03
                           10        20
                   ....*....|....*....|....*.
gi 1081349916    2 KIAIIGYSGSGKSTLANFLGQHYNCE 27
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPP 29
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 1-86 9.80e-03

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 35.09  E-value: 9.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349916   1 MKIAIIGYSGSGKSTLANFLGQHYNCEVLH-------------LDKIHFtSNW--QERTVDEMTDD--ISTFMLQRDWII 63
Cdd:TIGR02173   1 MIITISGPPGSGKTTVAKILAEKLSLKLISagdifrelaakmgLDLIEF-LNYaeENPEIDKKIDRriHEIALKEKNVVL 79

                          90       100
                  ....*....|....*....|...
gi 1081349916  64 EGNYSACLYEERmreADCIVYFN 86
Cdd:TIGR02173  80 ESRLAGWIVREY---ADVKIWLK 99
 
Name Accession Description Interval E-value
PRK07261 PRK07261
DNA topology modulation protein;
1-168 2.53e-114

DNA topology modulation protein;


Pssm-ID: 180911 [Multi-domain]  Cd Length: 171  Bit Score: 321.28  E-value: 2.53e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349916   1 MKIAIIGYSGSGKSTLANFLGQHYNCEVLHLDKIHFTSNWQERTVDEMTDDISTFMLQRDWIIEGNYSACLYEERMREAD 80
Cdd:PRK07261    1 MKIAIIGYSGSGKSTLARKLSQHYNCPVLHLDTLHFQPNWQERDDDDMIADISNFLLKHDWIIDGNYSWCLYEERMQEAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349916  81 CIVYFNFNRVNCLYRAFRRYLTYRGKTRPSIAEDCNEKFDFAFVKWILLDGRSKKYVEQYNVVVKNYSDKTIILKNQRQL 160
Cdd:PRK07261   81 QIIFLNFSRFNCLYRAFKRYLKYRGKTRESMAENCPEKFDWEFIKWILLDGRSKKQKENYQSVCQKYSHKTIVLKNQKEL 160


                  ....*...
gi 1081349916 161 NHYMKQVK 168
Cdd:PRK07261  161 DQYLKKIR 168
PRK08118 PRK08118
DNA topology modulation protein;
2-167 6.61e-49

DNA topology modulation protein;


Pssm-ID: 181235  Cd Length: 167  Bit Score: 155.54  E-value: 6.61e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349916   2 KIAIIGYSGSGKSTLANFLGQHYNCEVLHLDKIHFTSNWQERTVDEMTDDISTFMLQRDWIIEGNYSACLyEERMREADC 81
Cdd:PRK08118    3 KIILIGSGGSGKSTLARQLGEKLNIPVHHLDALFWKPNWEGVPKEEQITVQNELVKEDEWIIDGNYGGTM-DIRLNAADT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349916  82 IVYFNFNRVNCLYRAFRRYLTYRGKTRPSIAEDCNEKFDFAFVKWIlLDGRSKKYVEQYNVVVKNYSDKTI-ILKNQRQL 160
Cdd:PRK08118   82 IIFLDIPRTICLYRAFKRRVQYRGKTRPDMGAGCEEKFDLQFFKWI-WEYPKTKRPSILKRLNQLSEEKDIvILKSRNEV 160


                  ....*..
gi 1081349916 161 NHYMKQV 167
Cdd:PRK08118  161 RLFLEKI 167
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
1-83 2.86e-05

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 42.11  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349916   1 MKIAIIGYSGSGKSTLANFLGQHYNCEVLHLDKI-----HFTSNWQERT-----VDEMTDDISTfMLQRDWIIEGNYSAC 70
Cdd:COG1936     1 MRIAITGTPGTGKTTVAKLLAERLGLEVIHLNDLvkeegLYTEVDEERDslvvdEDALAEELEE-LKEGDVIIEGHLAHL 79

                          90
                  ....*....|...
gi 1081349916  71 LyeermrEADCIV 83
Cdd:COG1936    80 V------DVDRVI 86
PRK06547 PRK06547
hypothetical protein; Provisional
 1-35 2.95e-05

hypothetical protein; Provisional


Pssm-ID: 235825  Cd Length: 172  Bit Score: 42.04  E-value: 2.95e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1081349916   1 MKIAIIGYSGSGKSTLANFLGQHYNCEVLHLDKIH 35
Cdd:PRK06547   16 ITVLIDGRSGSGKTTLAGALAARTGFQLVHLDDLY 50
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
3-34 9.56e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 40.67  E-value: 9.56e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1081349916   3 IAIIGYSGSGKSTLANFLGQHYNCEVLHLDKI 34
Cdd:COG0645     2 ILVCGLPGSGKSTLARALAERLGAVRLRSDVV 33
NadR3 COG3172
Nicotinamide riboside kinase [Coenzyme transport and metabolism]; Nicotinamide riboside kinase ...
 1-26 1.02e-04

Nicotinamide riboside kinase [Coenzyme transport and metabolism]; Nicotinamide riboside kinase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 442405 [Multi-domain]  Cd Length: 178  Bit Score: 40.57  E-value: 1.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 1081349916   1 MKIAIIGYSGSGKSTLANFLGQHYNC 26
Cdd:COG3172     9 KKIVLLGAESTGKTTLARALAAHYNT 34
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
1-29 1.36e-04

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 40.54  E-value: 1.36e-04
                          10        20
                  ....*....|....*....|....*....
gi 1081349916   1 MKIAIIGYSGSGKSTLANFLGQHYNCEVL 29
Cdd:COG1428     4 RYIAVEGNIGAGKTTLARLLAEHLGAELL 32
AAA_28 pfam13521
AAA domain;
2-30 2.90e-04

AAA domain;


Pssm-ID: 433278 [Multi-domain]  Cd Length: 164  Bit Score: 39.17  E-value: 2.90e-04
                          10        20
                  ....*....|....*....|....*....
gi 1081349916   2 KIAIIGYSGSGKSTLANFLGQHYNCEVLH 30
Cdd:pfam13521   1 RIVITGGPSTGKTTLAEALAARFGYPVVP 29
MdlB COG1132
ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms];
2-18 5.27e-04

ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms];


Pssm-ID: 440747 [Multi-domain]  Cd Length: 579  Bit Score: 39.38  E-value: 5.27e-04
                          10
                  ....*....|....*..
gi 1081349916   2 KIAIIGYSGSGKSTLAN 18
Cdd:COG1132   368 TVALVGPSGSGKSTLVN 384
ABCC_MRP_Like cd03228
ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP ...
 2-24 5.42e-04

ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP (Multidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a diverse functional spectrum that includes ion transport, cell surface receptor, and toxin secretion activities. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains, each composed of six transmembrane (TM) helices, and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213195 [Multi-domain]  Cd Length: 171  Bit Score: 38.52  E-value: 5.42e-04
                          10        20
                  ....*....|....*....|...
gi 1081349916   2 KIAIIGYSGSGKSTLANFLGQHY 24
Cdd:cd03228    30 KVAIVGPSGSGKSTLLKLLLRLY 52
SunT COG2274
ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase ...
 2-20 1.16e-03

ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms];


Pssm-ID: 441875 [Multi-domain]  Cd Length: 711  Bit Score: 38.28  E-value: 1.16e-03
                          10
                  ....*....|....*....
gi 1081349916   2 KIAIIGYSGSGKSTLANFL 20
Cdd:COG2274   503 RVAIVGRSGSGKSTLLKLL 521
YlqF_related_GTPase cd01849
Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, ...
 2-47 1.21e-03

Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, and archaea. They all exhibit a circular permutation of the GTPase signature motifs so that the order of the conserved G box motifs is G4-G5-G1-G2-G3, with G4 and G5 being permuted from the C-terminal region of proteins in the Ras superfamily to the N-terminus of YlqF-related GTPases.


Pssm-ID: 206746 [Multi-domain]  Cd Length: 146  Bit Score: 37.36  E-value: 1.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1081349916   2 KIAIIGYSGSGKSTLANFLGQHYNCEVLHLDkiHFTSNWQERTVDE 47
Cdd:cd01849    93 RVGVVGLPNVGKSSFINALLNKFKLKVGSIP--GTTKLQQDVKLDK 136
CydC COG4987
ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease ...
 2-20 1.28e-03

ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444011 [Multi-domain]  Cd Length: 569  Bit Score: 38.21  E-value: 1.28e-03
                          10
                  ....*....|....*....
gi 1081349916   2 KIAIIGYSGSGKSTLANFL 20
Cdd:COG4987   363 RVAIVGPSGSGKSTLLALL 381
PRK04182 PRK04182
cytidylate kinase; Provisional
 1-28 1.38e-03

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 37.48  E-value: 1.38e-03
                          10        20
                  ....*....|....*....|....*...
gi 1081349916   1 MKIAIIGYSGSGKSTLANFLGQHYNCEV 28
Cdd:PRK04182    1 MIITISGPPGSGKTTVARLLAEKLGLKH 28
ABCG_EPDR cd03213
Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette ...
 3-28 1.44e-03

Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. Compared to other members of the ABC transporter subfamilies, the ABCG transporter family is composed of proteins that have an ATP-binding cassette domain at the N-terminus and a TM (transmembrane) domain at the C-terminus.


Pssm-ID: 213180 [Multi-domain]  Cd Length: 194  Bit Score: 37.53  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|....*..
gi 1081349916   3 IAIIGYSGSGKSTLANFL-GQHYNCEV 28
Cdd:cd03213    38 TAIMGPSGAGKSTLLNALaGRRTGLGV 64
LolD COG1136
ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];
3-21 1.68e-03

ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440751 [Multi-domain]  Cd Length: 227  Bit Score: 37.33  E-value: 1.68e-03
                          10
                  ....*....|....*....
gi 1081349916   3 IAIIGYSGSGKSTLANFLG 21
Cdd:COG1136    37 VAIVGPSGSGKSTLLNILG 55
PRK10535 PRK10535
macrolide ABC transporter ATP-binding protein/permease MacB;
3-21 2.04e-03

macrolide ABC transporter ATP-binding protein/permease MacB;


Pssm-ID: 182528 [Multi-domain]  Cd Length: 648  Bit Score: 37.78  E-value: 2.04e-03
                          10
                  ....*....|....*....
gi 1081349916   3 IAIIGYSGSGKSTLANFLG 21
Cdd:PRK10535   37 VAIVGASGSGKSTLMNILG 55
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 3-34 2.24e-03

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 36.76  E-value: 2.24e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1081349916   3 IAIIGYSGSGKSTLANFLGQHYNCEVLHLDKI 34
Cdd:cd00464     2 IVLIGMMGAGKTTVGRLLAKALGLPFVDLDEL 33
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 3-64 2.28e-03

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 36.52  E-value: 2.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1081349916   3 IAIIGYSGSGKSTLANFLGQHYNCEVLHLDkihftsNWQERTVDEMTDDISTFMLQRDWIIE 64
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSSD------DERKRLFGEGRPSISYYTDATDRTYE 57
CydD COG4988
ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease ...
 2-20 2.55e-03

ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444012 [Multi-domain]  Cd Length: 563  Bit Score: 37.43  E-value: 2.55e-03
                          10
                  ....*....|....*....
gi 1081349916   2 KIAIIGYSGSGKSTLANFL 20
Cdd:COG4988   365 RVALVGPSGAGKSTLLNLL 383
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 2-25 2.94e-03

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 36.31  E-value: 2.94e-03
                          10        20
                  ....*....|....*....|....
gi 1081349916   2 KIAIIGYSGSGKSTLANFLGQHYN 25
Cdd:cd02020     1 IIAIDGPAGSGKSTVAKLLAKKLG 24
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 2-27 3.70e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.20  E-value: 3.70e-03
                           10        20
                   ....*....|....*....|....*.
gi 1081349916    2 KIAIIGYSGSGKSTLANFLGQHYNCE 27
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPP 29
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 3-33 4.06e-03

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 35.87  E-value: 4.06e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1081349916   3 IAIIGYSGSGKSTLANFLGQHYNCEVLHLDK 33
Cdd:COG0703     1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDTDA 31
ABCC_Glucan_exporter_like cd03254
ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan ...
 1-25 4.26e-03

ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virulence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and lipid export. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains each composed of six transmembrane (TM) helices and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213221 [Multi-domain]  Cd Length: 229  Bit Score: 36.43  E-value: 4.26e-03
                          10        20
                  ....*....|....*....|....*
gi 1081349916   1 MKIAIIGYSGSGKSTLANFLGQHYN 25
Cdd:cd03254    30 ETVAIVGPTGAGKTTLINLLMRFYD 54
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 2-20 4.46e-03

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 35.29  E-value: 4.46e-03
                          10
                  ....*....|....*....
gi 1081349916   2 KIAIIGYSGSGKSTLANFL 20
Cdd:pfam01926   1 RVALVGRPNVGKSTLINAL 19
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
1-24 4.62e-03

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 36.16  E-value: 4.62e-03
                          10        20
                  ....*....|....*....|....*...
gi 1081349916   1 MKIAIIGYSGSGKST----LANFLGQHY 24
Cdd:COG0283     1 PVIAIDGPAGSGKSTvakaLAKRLGYHY 28
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 3-32 5.36e-03

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 35.76  E-value: 5.36e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1081349916   3 IAIIGYSGSGKSTLANFLGQHY-NCEVLHLD 32
Cdd:cd02024     2 VGISGVTNSGKTTLAKLLQRILpNCCVIHQD 32
AbcC COG1135
ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism];
4-20 6.82e-03

ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism];


Pssm-ID: 440750 [Multi-domain]  Cd Length: 339  Bit Score: 35.82  E-value: 6.82e-03
                          10        20
                  ....*....|....*....|
gi 1081349916   4 AIIGYSGSGKSTLA---NFL 20
Cdd:COG1135    35 GIIGYSGAGKSTLIrciNLL 54
ABC_MJ0796_LolCDE_FtsE cd03255
ATP-binding cassette domain of the transporters involved in export of lipoprotein and ...
 3-21 7.46e-03

ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.


Pssm-ID: 213222 [Multi-domain]  Cd Length: 218  Bit Score: 35.54  E-value: 7.46e-03
                          10
                  ....*....|....*....
gi 1081349916   3 IAIIGYSGSGKSTLANFLG 21
Cdd:cd03255    33 VAIVGPSGSGKSTLLNILG 51
ArpD COG4618
ABC-type protease/lipase transport system, ATPase and permease components [Intracellular ...
 3-17 7.94e-03

ABC-type protease/lipase transport system, ATPase and permease components [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443660 [Multi-domain]  Cd Length: 563  Bit Score: 35.88  E-value: 7.94e-03
                          10
                  ....*....|....*
gi 1081349916   3 IAIIGYSGSGKSTLA 17
Cdd:COG4618   361 LGVIGPSGSGKSTLA 375
PRK10790 PRK10790
SmdB family multidrug efflux ABC transporter permease/ATP-binding protein;
3-24 8.52e-03

SmdB family multidrug efflux ABC transporter permease/ATP-binding protein;


Pssm-ID: 182733 [Multi-domain]  Cd Length: 592  Bit Score: 35.85  E-value: 8.52e-03
                          10        20
                  ....*....|....*....|..
gi 1081349916   3 IAIIGYSGSGKSTLANFLGQHY 24
Cdd:PRK10790  370 VALVGHTGSGKSTLASLLMGYY 391
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 1-86 9.80e-03

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 35.09  E-value: 9.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349916   1 MKIAIIGYSGSGKSTLANFLGQHYNCEVLH-------------LDKIHFtSNW--QERTVDEMTDD--ISTFMLQRDWII 63
Cdd:TIGR02173   1 MIITISGPPGSGKTTVAKILAEKLSLKLISagdifrelaakmgLDLIEF-LNYaeENPEIDKKIDRriHEIALKEKNVVL 79

                          90       100
                  ....*....|....*....|...
gi 1081349916  64 EGNYSACLYEERmreADCIVYFN 86
Cdd:TIGR02173  80 ESRLAGWIVREY---ADVKIWLK 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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