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Conserved domains on  [gi|1081349562|gb|OFU87765|]
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hypothetical protein HMPREF3112_01295 [Streptococcus sp. HMSC10E12]

Protein Classification

sensor histidine kinase( domain architecture ID 11461754)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000155|GO:0004673|GO:0007165|GO:0005524
PubMed:  10339418|10637609
SCOP:  4001957

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 72-413 4.05e-33

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


:

Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 128.43  E-value: 4.05e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562  72 SRLLDVFYSFYPIVVESLIGRVLAFYLFPILGFNQVM--INTHYWINFIIEVSIYPLYFYFTKFVKIDFYNLQKGVKKNY 149
Cdd:COG3290     2 LLLLLLLLLLLILLILILILLLLLLIILLLILLLVLLllLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIAR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 150 LSRYFVLMNVSMFFYII-----------------LLQVLVIGE-------GFIPNAVEHREHLVGIYVVIFFVMLIYLNS 205
Cdd:COG3290    82 LVEEREAVLESIREGVIavdrdgritlindaarrLLGLDAIGRpidevlaEVLETGERDEEILLNGRVLVVNRVPIRDDG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 206 TLTEKLELEllyQKNKQLEELSVYSKHVESLYNEIRSFRHDYINVLTSIQEGIELKDIEAIQEVYDNVLSKTKENFSnsk 285
Cdd:COG3290   162 RVVGAVATF---RDRTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELID--- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 286 ydfANLSNITNTAIKSVVSAKLLEAQSKNVEVHIEVESLVSLSNMDALDIITILSILLDNAIEAA--CLAEKPCLTLAIF 363
Cdd:COG3290   236 ---SLLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVekLPEEERRVELSIR 312

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1081349562 364 QEKDSDIIVVENS---IREEKINisKIFDLGYSSK-GENRGIGLSNVHDILDKY 413
Cdd:COG3290   313 DDGDELVIEVEDSgpgIPEELLE--KIFERGFSTKlGEGRGLGLALVKQIVEKY 364
 
Name Accession Description Interval E-value
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 72-413 4.05e-33

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 128.43  E-value: 4.05e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562  72 SRLLDVFYSFYPIVVESLIGRVLAFYLFPILGFNQVM--INTHYWINFIIEVSIYPLYFYFTKFVKIDFYNLQKGVKKNY 149
Cdd:COG3290     2 LLLLLLLLLLLILLILILILLLLLLIILLLILLLVLLllLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIAR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 150 LSRYFVLMNVSMFFYII-----------------LLQVLVIGE-------GFIPNAVEHREHLVGIYVVIFFVMLIYLNS 205
Cdd:COG3290    82 LVEEREAVLESIREGVIavdrdgritlindaarrLLGLDAIGRpidevlaEVLETGERDEEILLNGRVLVVNRVPIRDDG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 206 TLTEKLELEllyQKNKQLEELSVYSKHVESLYNEIRSFRHDYINVLTSIQEGIELKDIEAIQEVYDNVLSKTKENFSnsk 285
Cdd:COG3290   162 RVVGAVATF---RDRTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELID--- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 286 ydfANLSNITNTAIKSVVSAKLLEAQSKNVEVHIEVESLVSLSNMDALDIITILSILLDNAIEAA--CLAEKPCLTLAIF 363
Cdd:COG3290   236 ---SLLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVekLPEEERRVELSIR 312

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1081349562 364 QEKDSDIIVVENS---IREEKINisKIFDLGYSSK-GENRGIGLSNVHDILDKY 413
Cdd:COG3290   313 DDGDELVIEVEDSgpgIPEELLE--KIFERGFSTKlGEGRGLGLALVKQIVEKY 364
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 298-433 1.10e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 93.02  E-value: 1.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 298 AIKSVVSAKLLEAQSKNVEVHIEVESLVSLsNMDALDIITILSILLDNAIEAA--CLAEKPCLTLAIFQEKDSDIIVVEN 375
Cdd:cd16935     1 ALDSLLSEKLELAREKGIEFTIEIDIPILL-PISPLDLCIIFGNLLDNAIEACakIDKENRFIHLKIRQKKGFLIISIEN 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1081349562 376 SIREEkinISKIFDLGYSSKGE-NRGIGLSNVHDILDKYpAAFIKTSSRKHLFRQTIEI 433
Cdd:cd16935    80 SYEGE---LKKKNGLFLSTKKDkNHGIGLKSIREIVKKY-NGNLSIEYENGIFTLSILL 134
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 330-433 4.66e-17

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 76.10  E-value: 4.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 330 MDALDIITILSILLDNAIEAA-CLAEKPCLTLAIFQEKDSDIIVVENSIREEKINISKIFDlgYSSKGENRGIGLSNVHD 408
Cdd:pfam14501   1 ISDVDLCVIFGNLLDNAIEACsKIDDNRFIRLKIREKQNFLIIRIENTYEGELKFEGKLPS--TKTKGDGHGIGLKSIRR 78

                          90       100
                  ....*....|....*....|....*
gi 1081349562 409 ILDKYPaAFIKTSSRKHLFRQTIEI 433
Cdd:pfam14501  79 IVKKYG-GNLSTEIENGIFTLSILL 102
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 299-404 5.25e-09

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 58.00  E-value: 5.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 299 IKSVVSA-----KLLEAQSKNVEVHIEVESLV--SLSNMDALDIITILSILLDNAIEAACLAEKPCLTLAI-FQEKDSDI 370
Cdd:PRK11086  391 IKSPVIAgfllgKISRARELGITLIISEDSQLpdSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLhYRNGWLHC 470

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1081349562 371 IVVENSIREEKINISKIFDLGYSSKGENRGIGLS 404
Cdd:PRK11086  471 EVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLY 504
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 330-413 2.00e-07

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 49.18  E-value: 2.00e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562  330 MDALDIITILSILLDNAIEAAclAEKPCLTLAIFQEKDSDIIVVENS---IREEKINisKIFDLGYSSKGENR-----GI 401
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYT--PEGGRITVTLERDGDHVEITVEDNgpgIPPEDLE--KIFEPFFRTDKRSRkiggtGL 76

                           90
                   ....*....|..
gi 1081349562  402 GLSNVHDILDKY 413
Cdd:smart00387  77 GLSIVKKLVELH 88
 
Name Accession Description Interval E-value
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 72-413 4.05e-33

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 128.43  E-value: 4.05e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562  72 SRLLDVFYSFYPIVVESLIGRVLAFYLFPILGFNQVM--INTHYWINFIIEVSIYPLYFYFTKFVKIDFYNLQKGVKKNY 149
Cdd:COG3290     2 LLLLLLLLLLLILLILILILLLLLLIILLLILLLVLLllLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIAR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 150 LSRYFVLMNVSMFFYII-----------------LLQVLVIGE-------GFIPNAVEHREHLVGIYVVIFFVMLIYLNS 205
Cdd:COG3290    82 LVEEREAVLESIREGVIavdrdgritlindaarrLLGLDAIGRpidevlaEVLETGERDEEILLNGRVLVVNRVPIRDDG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 206 TLTEKLELEllyQKNKQLEELSVYSKHVESLYNEIRSFRHDYINVLTSIQEGIELKDIEAIQEVYDNVLSKTKENFSnsk 285
Cdd:COG3290   162 RVVGAVATF---RDRTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELID--- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 286 ydfANLSNITNTAIKSVVSAKLLEAQSKNVEVHIEVESLVSLSNMDALDIITILSILLDNAIEAA--CLAEKPCLTLAIF 363
Cdd:COG3290   236 ---SLLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVekLPEEERRVELSIR 312

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1081349562 364 QEKDSDIIVVENS---IREEKINisKIFDLGYSSK-GENRGIGLSNVHDILDKY 413
Cdd:COG3290   313 DDGDELVIEVEDSgpgIPEELLE--KIFERGFSTKlGEGRGLGLALVKQIVEKY 364
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 298-433 1.10e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 93.02  E-value: 1.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 298 AIKSVVSAKLLEAQSKNVEVHIEVESLVSLsNMDALDIITILSILLDNAIEAA--CLAEKPCLTLAIFQEKDSDIIVVEN 375
Cdd:cd16935     1 ALDSLLSEKLELAREKGIEFTIEIDIPILL-PISPLDLCIIFGNLLDNAIEACakIDKENRFIHLKIRQKKGFLIISIEN 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1081349562 376 SIREEkinISKIFDLGYSSKGE-NRGIGLSNVHDILDKYpAAFIKTSSRKHLFRQTIEI 433
Cdd:cd16935    80 SYEGE---LKKKNGLFLSTKKDkNHGIGLKSIREIVKKY-NGNLSIEYENGIFTLSILL 134
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
13-435 3.08e-18

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 86.61  E-value: 3.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562  13 HIIVVLLLYQHISGNKFKWYWFIIFPITFRILFLLVPPLAYFAYIFFLPVYSLYRNKYGSRLLDVFYSFYPIVVESLIGR 92
Cdd:COG2972    32 IILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSLLLLLALILLLAL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562  93 VLAFYLFPILGFNQVMINTHYWINFIIEVSIYPLYFYFTKFVKIDFYNLQKGVKKNYLS---RYFVLMNVSMFFYIILLQ 169
Cdd:COG2972   112 LLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLAlllSYLLSRSITRPIKRLKKA 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 170 VLVIGEGFIPNAVEHREHLVGIYVVIFFVMLIYLNSTLteklelellyQKNKQLEELSvysKHVESLYNEIRSFRHDYIN 249
Cdd:COG2972   192 MKKVEKGDLVRLEVSGNDEIGILARSFNEMVERIKELI----------EEVYELELEK---KEAELKALQAQINPHFLFN 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 250 VLTSIQEGIELKDIEAIQEVYDNVLSKTKENFSNSKyDFANLsNITNTAIKSVVSAKLLEAQSKnVEVHIEVESLVslsn 329
Cdd:COG2972   259 TLNSIRWLAELEDPEEAEEMLEALSKLLRYSLSKGD-ELVTL-EEELELIKSYLEIQKLRFGDR-LEVEIEIDEEL---- 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 330 MDALDIITILSILLDNAIEAA--CLAEKPCLTLAIFQEKDSDIIVVENS---IREEKINisKIFDlGYSSKGENRGIGLS 404
Cdd:COG2972   332 LDLLIPKLILQPLVENAIEHGiePKEGGGTIRISIRKEGDRLVITVEDNgvgMPEEKLE--KLLE-ELSSKGEGRGIGLR 408

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1081349562 405 NVHDILDKY--PAAFIKTSSRKHL-FRQTIEIKR 435
Cdd:COG2972   409 NVRERLKLYygEEYGLEIESEPGEgTTVTIRIPL 442
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 330-433 4.66e-17

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 76.10  E-value: 4.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 330 MDALDIITILSILLDNAIEAA-CLAEKPCLTLAIFQEKDSDIIVVENSIREEKINISKIFDlgYSSKGENRGIGLSNVHD 408
Cdd:pfam14501   1 ISDVDLCVIFGNLLDNAIEACsKIDDNRFIRLKIREKQNFLIIRIENTYEGELKFEGKLPS--TKTKGDGHGIGLKSIRR 78

                          90       100
                  ....*....|....*....|....*
gi 1081349562 409 ILDKYPaAFIKTSSRKHLFRQTIEI 433
Cdd:pfam14501  79 IVKKYG-GNLSTEIENGIFTLSILL 102
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 299-404 5.25e-09

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 58.00  E-value: 5.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 299 IKSVVSA-----KLLEAQSKNVEVHIEVESLV--SLSNMDALDIITILSILLDNAIEAACLAEKPCLTLAI-FQEKDSDI 370
Cdd:PRK11086  391 IKSPVIAgfllgKISRARELGITLIISEDSQLpdSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLhYRNGWLHC 470

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1081349562 371 IVVENSIREEKINISKIFDLGYSSKGENRGIGLS 404
Cdd:PRK11086  471 EVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLY 504
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 336-409 1.12e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 52.67  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 336 ITILSILLDNAIEAACLAEKPC--LTLAIFQEKDSDIIVVENS---IREEKINisKIFDLGYSSKGE-NRGIGLSNVHDI 409
Cdd:cd16915     2 ITIVGNLIDNALDALAATGAPNkqVEVFLRDEGDDLVIEVRDTgpgIAPELRD--KVFERGVSTKGQgERGIGLALVRQS 79
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
299-413 1.61e-08

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 56.07  E-value: 1.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 299 IKSVVSAKLLEAQSKNVEVHIEVESLVSLSNMDALDIITILSILLDNAIEAAclAEKPCLTLAIFQEKDSDIIVVENS-- 376
Cdd:COG0642   188 LEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYT--PEGGTVTVSVRREGDRVRISVEDTgp 265

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1081349562 377 -IREEKinISKIFDLGYSSKGENR----GIGLSNVHDILDKY 413
Cdd:COG0642   266 gIPPED--LERIFEPFFRTDPSRRgggtGLGLAIVKRIVELH 305
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
218-413 1.71e-07

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 51.83  E-value: 1.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 218 QKNKQLEELsvyskhvESLYNE-IRSFRHDYINVLTSIQEGIEL----------KDIEAIQEVYDNV------------L 274
Cdd:COG2205     4 EALEELEEL-------ERLKSEfLANVSHELRTPLTSILGAAELlldeedlspeERRELLEIIRESAerllrliedlldL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 275 SKTKENFSNSKYDFANLSNItntaIKSVVSAKLLEAQSKNVEVHIEVESLVSLSNMDALDIITILSILLDNAIEAAclAE 354
Cdd:COG2205    77 SRLESGKLSLELEPVDLAEL----LEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYS--PP 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1081349562 355 KPCLTLAIFQEKDSDIIVVENS---IREEKinISKIFDLGYSSKGENR----GIGLSNVHDILDKY 413
Cdd:COG2205   151 GGTITISARREGDGVRISVSDNgpgIPEEE--LERIFERFYRGDNSRGeggtGLGLAIVKRIVEAH 214
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 330-413 2.00e-07

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 49.18  E-value: 2.00e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562  330 MDALDIITILSILLDNAIEAAclAEKPCLTLAIFQEKDSDIIVVENS---IREEKINisKIFDLGYSSKGENR-----GI 401
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYT--PEGGRITVTLERDGDHVEITVEDNgpgIPPEDLE--KIFEPFFRTDKRSRkiggtGL 76

                           90
                   ....*....|..
gi 1081349562  402 GLSNVHDILDKY 413
Cdd:smart00387  77 GLSIVKKLVELH 88
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 309-411 5.34e-06

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 48.42  E-value: 5.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 309 EAQSKNVEVHIEVESLVSLSNMDALDIITILSILLDNAIEAacLAEKPCLTLAIFQEKDSDIIVVENS---IREEkiNIS 385
Cdd:COG5000   292 ALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEA--IEEGGEIEVSTRREDGRVRIEVSDNgpgIPEE--VLE 367

                          90       100
                  ....*....|....*....|....*.
gi 1081349562 386 KIFDLGYSSKGENRGIGLSNVHDILD 411
Cdd:COG5000   368 RIFEPFFTTKPKGTGLGLAIVKKIVE 393
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 296-413 7.95e-06

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 47.87  E-value: 7.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 296 NTAIKSVVSakLLEAQ--SKNVEVHIEVESLVSLSNMDALDIITILSILLDNAIEAACLAEKPCLTLAIFQEKDSDIIVV 373
Cdd:COG4191   218 NELIDEALE--LLRPRlkARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISV 295

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1081349562 374 ENS---IREEkiNISKIFDLGYSSK--GENRGIGLSNVHDILDKY 413
Cdd:COG4191   296 RDNgpgIPPE--VLERIFEPFFTTKpvGKGTGLGLSISYGIVEKH 338
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 330-413 1.58e-05

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 43.90  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 330 MDALDIITILSILLDNAIEAACLAEKPCLTLaifQEKDSDIIVVENS---IREEKI-NISKIFDLGYSSKGENRGIGLSN 405
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTL---SEGGELTLTVEDNgigIPPEDLpRIFEPFSTADKRGGGGTGLGLSI 77


                  ....*...
gi 1081349562 406 VHDILDKY 413
Cdd:pfam02518  78 VRKLVELL 85
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
309-423 1.15e-03

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 40.93  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 309 EAQSKNVEVHIEVESLVSLSNMDALDIITILSILLDNAIEAacLAEKPCLTLAIFQEKDSDIIVVENS---IREEKINis 385
Cdd:PRK10364  323 DANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQA--IGQHGVISVTASESGAGVKISVTDSgkgIAADQLE-- 398

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1081349562 386 KIFDLGYSSKGENRGIGLSNVHDILDKYPAAfIKTSSR 423
Cdd:PRK10364  399 AIFTPYFTTKAEGTGLGLAVVHNIVEQHGGT-IQVASQ 435
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
299-413 3.11e-03

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 39.54  E-value: 3.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081349562 299 IKSVVSAKLLEAQSKNVEVHIEVESLVSLSNMDALDIITILSILLDNAIEAAclAEKPCLTLAIFQEKDSDIIVVENS-- 376
Cdd:COG5002   246 LEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYT--PEGGTITVSLREEDDQVRISVRDTgi 323

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1081349562 377 -IREEkiNISKIFDLGY-SSKGENR-----GIGLSNVHDILDKY 413
Cdd:COG5002   324 gIPEE--DLPRIFERFYrVDKSRSRetggtGLGLAIVKHIVEAH 365
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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