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Conserved domains on  [gi|1034734388|gb|OAV88540|]
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hypothetical protein PTTG_06886 [Puccinia triticina 1-1 BBBD Race 1]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 214-431 1.26e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 1.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 214 HGCPVHALAVPPCGTHLFSGGQDGFVRriaIHESVTGSGLENLTmkqgGH---VPLVDKDTDRTTIFLAGYwenDDQNSL 290
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIK---VWDLETGELLRTLK----GHtgpVRDVAASADGTYLASGSS---DKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 291 lepaspnpplkW---GPKSVGNATQV-SPVYSLAIHDEELWGLSGTELGNINLFTIRhdEGHIRHVFKaanppsavplts 366
Cdd:cd00200    78 -----------WdleTGECVRTLTGHtSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLR------------ 132

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034734388 367 asdvkGHKpgSVISALALNSDQNIAFSGGWDGIVLGWDLNTGQVVNKFIAHASQISTVALRPDSR 431
Cdd:cd00200   133 -----GHT--DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGE 190
WD40 COG2319
WD40 repeat [General function prediction only];
633-804 1.79e-07

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 633 LMTSGIDGQVYLWDRRvsgSGsagyvRKLDLPKATSPWTASASWSIDGRSVFVGRRNHSVDLYDLRflrpnspifNPDAI 712
Cdd:COG2319   261 LASGSADGTVRLWDLA---TG-----ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA---------TGKLL 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 713 QRsikLPPSSGPVSCVKPWPDGSHLLCASFDN-LRLYNLNADLHPTSLSsarksthhppkipfkiipGHSSGVVSqMCVT 791
Cdd:COG2319   324 RT---LTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLT------------------GHTGAVTS-VAFS 381

                         170
                  ....*....|...
gi 1034734388 792 PSFRFLITASGDR 804
Cdd:COG2319   382 PDGRTLASGSADG 394
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 214-431 1.26e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 1.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 214 HGCPVHALAVPPCGTHLFSGGQDGFVRriaIHESVTGSGLENLTmkqgGH---VPLVDKDTDRTTIFLAGYwenDDQNSL 290
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIK---VWDLETGELLRTLK----GHtgpVRDVAASADGTYLASGSS---DKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 291 lepaspnpplkW---GPKSVGNATQV-SPVYSLAIHDEELWGLSGTELGNINLFTIRhdEGHIRHVFKaanppsavplts 366
Cdd:cd00200    78 -----------WdleTGECVRTLTGHtSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLR------------ 132

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034734388 367 asdvkGHKpgSVISALALNSDQNIAFSGGWDGIVLGWDLNTGQVVNKFIAHASQISTVALRPDSR 431
Cdd:cd00200   133 -----GHT--DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGE 190
WD40 COG2319
WD40 repeat [General function prediction only];
210-431 4.74e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 4.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 210 VFIPHGCPVHALAVPPCGTHLFSGGQDGFVRriaIHESVTGSGLENLTmkqgGHVPLVDK---DTDRTTIFLAGYwenDD 286
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVR---LWDLATGKLLRTLT----GHSGSVRSvafSPDGRLLASGSA---DG 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 287 QNSLLEPASPNPPLKWGPKSvgnatqvSPVYSLAIHDEELWGLSGTELGNINLFTIrhDEGHIRHVFKaanppsavplts 366
Cdd:COG2319   269 TVRLWDLATGELLRTLTGHS-------GGVNSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLT------------ 327

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034734388 367 asdvkGHkpGSVISALALNSDQNIAFSGGWDGIVLGWDLNTGQVVNKFIAHASQISTVALRPDSR 431
Cdd:COG2319   328 -----GH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR 385
WD40 COG2319
WD40 repeat [General function prediction only];
633-804 1.79e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 633 LMTSGIDGQVYLWDRRvsgSGsagyvRKLDLPKATSPWTASASWSIDGRSVFVGRRNHSVDLYDLRflrpnspifNPDAI 712
Cdd:COG2319   261 LASGSADGTVRLWDLA---TG-----ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA---------TGKLL 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 713 QRsikLPPSSGPVSCVKPWPDGSHLLCASFDN-LRLYNLNADLHPTSLSsarksthhppkipfkiipGHSSGVVSqMCVT 791
Cdd:COG2319   324 RT---LTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLT------------------GHTGAVTS-VAFS 381

                         170
                  ....*....|...
gi 1034734388 792 PSFRFLITASGDR 804
Cdd:COG2319   382 PDGRTLASGSADG 394
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 629-814 4.10e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 4.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 629 NDDVLMTSGIDGQVYLWDRRvsgSGSAGYVRKldlpkATSPWTASASWSIDGRSVFVGRRNHSVDLYDLRFLRPnspifn 708
Cdd:cd00200   104 DGRILSSSSRDKTIKVWDVE---TGKCLTTLR-----GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC------ 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 709 pdaIQRsikLPPSSGPVSCVKPWPDGSHLLCASFDN-LRLYNLNAdlhptslssarksthhppKIPFKIIPGHSSGVVSq 787
Cdd:cd00200   170 ---VAT---LTGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDLST------------------GKCLGTLRGHENGVNS- 224

                         170       180       190
                  ....*....|....*....|....*....|
gi 1034734388 788 MCVTPSFRFLITASGD---RGWQSTSNESV 814
Cdd:cd00200   225 VAFSPDGYLLASGSEDgtiRVWDLRTGECV 254
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 214-431 1.26e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 1.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 214 HGCPVHALAVPPCGTHLFSGGQDGFVRriaIHESVTGSGLENLTmkqgGH---VPLVDKDTDRTTIFLAGYwenDDQNSL 290
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIK---VWDLETGELLRTLK----GHtgpVRDVAASADGTYLASGSS---DKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 291 lepaspnpplkW---GPKSVGNATQV-SPVYSLAIHDEELWGLSGTELGNINLFTIRhdEGHIRHVFKaanppsavplts 366
Cdd:cd00200    78 -----------WdleTGECVRTLTGHtSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLR------------ 132

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034734388 367 asdvkGHKpgSVISALALNSDQNIAFSGGWDGIVLGWDLNTGQVVNKFIAHASQISTVALRPDSR 431
Cdd:cd00200   133 -----GHT--DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGE 190
WD40 COG2319
WD40 repeat [General function prediction only];
210-431 4.74e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 4.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 210 VFIPHGCPVHALAVPPCGTHLFSGGQDGFVRriaIHESVTGSGLENLTmkqgGHVPLVDK---DTDRTTIFLAGYwenDD 286
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVR---LWDLATGKLLRTLT----GHSGSVRSvafSPDGRLLASGSA---DG 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 287 QNSLLEPASPNPPLKWGPKSvgnatqvSPVYSLAIHDEELWGLSGTELGNINLFTIrhDEGHIRHVFKaanppsavplts 366
Cdd:COG2319   269 TVRLWDLATGELLRTLTGHS-------GGVNSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLT------------ 327

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034734388 367 asdvkGHkpGSVISALALNSDQNIAFSGGWDGIVLGWDLNTGQVVNKFIAHASQISTVALRPDSR 431
Cdd:COG2319   328 -----GH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR 385
WD40 COG2319
WD40 repeat [General function prediction only];
633-804 1.79e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 633 LMTSGIDGQVYLWDRRvsgSGsagyvRKLDLPKATSPWTASASWSIDGRSVFVGRRNHSVDLYDLRflrpnspifNPDAI 712
Cdd:COG2319   261 LASGSADGTVRLWDLA---TG-----ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA---------TGKLL 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 713 QRsikLPPSSGPVSCVKPWPDGSHLLCASFDN-LRLYNLNADLHPTSLSsarksthhppkipfkiipGHSSGVVSqMCVT 791
Cdd:COG2319   324 RT---LTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLT------------------GHTGAVTS-VAFS 381

                         170
                  ....*....|...
gi 1034734388 792 PSFRFLITASGDR 804
Cdd:COG2319   382 PDGRTLASGSADG 394
WD40 COG2319
WD40 repeat [General function prediction only];
633-818 3.83e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.38  E-value: 3.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 633 LMTSGIDGQVYLWDRRvsgsgSAGYVRKLdlpKATSPWTASASWSIDGRSVFVGRRNHSVDLYDLRflrpnspifNPDAI 712
Cdd:COG2319   177 LASGSDDGTVRLWDLA-----TGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA---------TGKLL 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 713 QRsikLPPSSGPVSCVKPWPDGSHLLCASFDN-LRLYNLNADLHPTSLssarksthhppkipfkiiPGHSSGVVSqMCVT 791
Cdd:COG2319   240 RT---LTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATGELLRTL------------------TGHSGGVNS-VAFS 297

                         170       180       190
                  ....*....|....*....|....*....|
gi 1034734388 792 PSFRFLITASGDRG---WQSTSNESVVIHE 818
Cdd:COG2319   298 PDGKLLASGSDDGTvrlWDLATGKLLRTLT 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 629-814 4.10e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 4.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 629 NDDVLMTSGIDGQVYLWDRRvsgSGSAGYVRKldlpkATSPWTASASWSIDGRSVFVGRRNHSVDLYDLRFLRPnspifn 708
Cdd:cd00200   104 DGRILSSSSRDKTIKVWDVE---TGKCLTTLR-----GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC------ 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 709 pdaIQRsikLPPSSGPVSCVKPWPDGSHLLCASFDN-LRLYNLNAdlhptslssarksthhppKIPFKIIPGHSSGVVSq 787
Cdd:cd00200   170 ---VAT---LTGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDLST------------------GKCLGTLRGHENGVNS- 224

                         170       180       190
                  ....*....|....*....|....*....|
gi 1034734388 788 MCVTPSFRFLITASGD---RGWQSTSNESV 814
Cdd:cd00200   225 VAFSPDGYLLASGSEDgtiRVWDLRTGECV 254
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 314-432 1.22e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 314 SPVYSLAIHDEELWGLSGTELGNINLFTIRHDEGHIRhvfkaanppsavpltsasdVKGHKPGsvISALALNSDQNIAFS 393
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-------------------LKGHTGP--VRDVAASADGTYLAS 68

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034734388 394 GGWDGIVLGWDLNTGQVVNKFIAHASQISTVALRPDSRV 432
Cdd:cd00200    69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRI 107
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 210-432 1.47e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 210 VFIPHGCPVHALAVPPCGTHLFSGGQDGFVRriaIHESVTGSGLENLTmkqgGHVplvdkdtdrttiflagywenddqns 289
Cdd:cd00200   130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIK---LWDLRTGKCVATLT----GHT------------------------- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 290 llepaspnpplkwgpksvgnatqvSPVYSLAIHDEELWGLSGTELGNINLFTIRhdEGHIRHVFKaanppsavpltsasd 369
Cdd:cd00200   178 ------------------------GEVNSVAFSPDGEKLLSSSSDGTIKLWDLS--TGKCLGTLR--------------- 216

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034734388 370 vkGHKPGsvISALALNSDQNIAFSGGWDGIVLGWDLNTGQVVNKFIAHASQISTVALRPDSRV 432
Cdd:cd00200   217 --GHENG--VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 370-431 2.09e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 2.09e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034734388 370 VKGHKpgSVISALALNSDQNIAFSGGWDGIVLGWDLNTGQVVNKFIAHASQISTVALRPDSR 431
Cdd:cd00200     5 LKGHT--GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT 64
WD40 COG2319
WD40 repeat [General function prediction only];
633-804 3.51e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 3.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 633 LMTSGIDGQVYLWDRRvsgSGsagyvRKLDLPKATSPWTASASWSIDGRSVFVGRRNHSVDLYDLRflrpnspifNPDAI 712
Cdd:COG2319   135 LASGSADGTVRLWDLA---TG-----KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA---------TGKLL 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 713 QRsikLPPSSGPVSCVKPWPDGSHLLCASFDN-LRLYNLNADLHPTSLssarksthhppkipfkiiPGHSSGVVSqMCVT 791
Cdd:COG2319   198 RT---LTGHTGAVRSVAFSPDGKLLASGSADGtVRLWDLATGKLLRTL------------------TGHSGSVRS-VAFS 255

                         170
                  ....*....|...
gi 1034734388 792 PSFRFLITASGDR 804
Cdd:COG2319   256 PDGRLLASGSADG 268
WD40 COG2319
WD40 repeat [General function prediction only];
198-432 4.10e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.91  E-value: 4.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 198 RKFERAPTIDPLVFIPHGCPVHALAVPPCGTHLFSGGQDGFVRriaIHESVTGSGLENLTmkqgGHVPLVDK---DTDRT 274
Cdd:COG2319   103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVR---LWDLATGKLLRTLT----GHSGAVTSvafSPDGK 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 275 TIFLAGywenDDQNSLLepaspnpplkWgpksvgNATQVSPVYSLAIHDEELWGL----------SGTELGNINLFTIrh 344
Cdd:COG2319   176 LLASGS----DDGTVRL----------W------DLATGKLLRTLTGHTGAVRSVafspdgkllaSGSADGTVRLWDL-- 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 345 DEGHIRHVFKaanppsavpltsasdvkGHkpGSVISALALNSDQNIAFSGGWDGIVLGWDLNTGQVVNKFIAHASQISTV 424
Cdd:COG2319   234 ATGKLLRTLT-----------------GH--SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294


                  ....*...
gi 1034734388 425 ALRPDSRV 432
Cdd:COG2319   295 AFSPDGKL 302
WD40 COG2319
WD40 repeat [General function prediction only];
629-751 1.96e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 629 NDDVLMTSGIDGQVYLWDRRvsgSGsagyvRKLDLPKATSPWTASASWSIDGRSVFVGRRNHSVDLYDLrflrpnspifn 708
Cdd:COG2319   299 DGKLLASGSDDGTVRLWDLA---TG-----KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL----------- 359

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1034734388 709 pDAIQRSIKLPPSSGPVSCVKPWPDGSHLLCASFDN-LRLYNLN 751
Cdd:COG2319   360 -ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGtVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
342-431 2.09e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 2.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 342 IRHDEGHIRHVFKAANPPSAVPLTSAS--------DVKGHKP-------GSVISALALNSDQNIAFSGGWDGIVLGWDLN 406
Cdd:COG2319    71 LATLLGHTAAVLSVAFSPDGRLLASASadgtvrlwDLATGLLlrtltghTGAVRSVAFSPDGKTLASGSADGTVRLWDLA 150

                          90       100
                  ....*....|....*....|....*
gi 1034734388 407 TGQVVNKFIAHASQISTVALRPDSR 431
Cdd:COG2319   151 TGKLLRTLTGHSGAVTSVAFSPDGK 175
WD40 COG2319
WD40 repeat [General function prediction only];
582-804 5.29e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 5.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 582 PTAPPLILPTVATSKARNVLPLMKKPVLPATNLTQVPSVLDSSLPVINDDVLMTSGIDGQVYLWD-----RRVSGSGSAG 656
Cdd:COG2319    42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDlatglLLRTLTGHTG 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 657 YVRkldlpkatspwtaSASWSIDGRSVFVGRRNHSVDLYDLRflrpnspifNPDAIQRsikLPPSSGPVSCVKPWPDGSH 736
Cdd:COG2319   122 AVR-------------SVAFSPDGKTLASGSADGTVRLWDLA---------TGKLLRT---LTGHSGAVTSVAFSPDGKL 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034734388 737 LLCASFDN-LRLYNLNADLHPTSLssarksthhppkipfkiiPGHSSGVVSqMCVTPSFRFLITASGDR 804
Cdd:COG2319   177 LASGSDDGtVRLWDLATGKLLRTL------------------TGHTGAVRS-VAFSPDGKLLASGSADG 226
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 629-749 1.30e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034734388 629 NDDVLMTSGIDGQVYLWDRRvSGS------GSAGYVRkldlpkatspwtaSASWSIDGRSVFVGRRNHSVDLYDLRFLRP 702
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLR-TGKcvatltGHTGEVN-------------SVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034734388 703 -----------NSPIFNPD-------AIQRSIK------------LPPSSGPVSCVKPWPDGSHLLCASFDN-LRLYN 749
Cdd:cd00200   212 lgtlrghengvNSVAFSPDgyllasgSEDGTIRvwdlrtgecvqtLSGHTNSVTSLAWSPDGKRLASGSADGtIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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