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Conserved domains on  [gi|108884809|sp|O95479|]
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RecName: Full=GDH/6PGL endoplasmic bifunctional protein; Includes: RecName: Full=Hexose-6-phosphate dehydrogenase; AltName: Full=Glucose 1-dehydrogenase; Short=GDH; AltName: Full=Glucose-6-phosphate dehydrogenase; Includes: RecName: Full=6-phosphogluconolactonase; Short=6PGL; Flags: Precursor

Protein Classification

6-phosphogluconolactonase; glucosamine/galactosamine-6-phosphate isomerase/deaminase family protein( domain architecture ID 13232975)

6-phosphogluconolactonase catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate, which is the the second step of the oxidative phase of the pentose phosphate pathway; glucosamine/galactosamine-6-phosphate isomerase/deaminase family protein similar to Escherichia coli protein YieK

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 556-791 4.47e-99

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


:

Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 306.61  E-value: 4.47e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  556 VSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHygFPWAHTHLWLVDERCVPLSDPESNFQG 635
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQP--LDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  636 LQAHLLQHVRIPYYNIHPMPVHLQqrlcaEEDQGAQIYAREISALVAN---SSFDLVLLGMGADGHTASLFPQSPTGLDG 712
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTELS-----DIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  713 EQLV-VLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLpHSGQLVWYMDYDAFLG 791
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVL-HSGKTLWLLDYAAARK 232
PTZ00309 super family cl29403
glucose-6-phosphate 1-dehydrogenase; Provisional
 26-504 1.08e-98

glucose-6-phosphate 1-dehydrogenase; Provisional


The actual alignment was detected with superfamily member PTZ00309:

Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 316.69  E-value: 1.08e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  26 VSIILLGATGDLAKKYLWQGLFQLYLdEAGRGHSFSFHGAALTA-PKQGQ---ELMAKALESLSCPkdmapshcAEHKDQ 101
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYC-EGLLPSEVNIVGYARSKmSDVERwkkETLARFFKRLDDR--------ECHLEQ 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 102 FLQLSQYR--QLKTAEDYQALNKDIEAQLQHAGLREAG--RIFYFSVPPFAYEDIARNINSSCRPGPGaWLRVVLEKPFG 177
Cdd:PTZ00309 126 FLKHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFG 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 178 HDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEY 257
Cdd:PTZ00309 205 RDLESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSY 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 258 GVIRDVLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRGSAVVGQY-QSYSEQVRRELQKPD-SFHSLTP 335
Cdd:PTZ00309 284 GIIRDVMQNHLLQILALLAMEKPVSL-SAEDIRDEKVKVLKCIEPIKMEECVLGQYtASADGSIPGYLEDEGvPKDSTTP 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 336 TFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNqaccvQSEKHWAAAQSQclPRQLVFHIGhgdlGSPAVLVS 415
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----VDEFRPSGDDTQ--RNELVIRAQ----PSEAMYLK 431

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 416 RNLFRPSLPSSWKEMEgppgLRLfgsplsDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAH 495
Cdd:PTZ00309 432 ITAKVPGLSNDLHQTE----LDL------TYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDR 501

                        490
                 ....*....|.
gi 108884809 496 K--APRLYPGG 504
Cdd:PTZ00309 502 GevKPEPYPFG 512
 
Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 556-791 4.47e-99

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 306.61  E-value: 4.47e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  556 VSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHygFPWAHTHLWLVDERCVPLSDPESNFQG 635
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQP--LDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  636 LQAHLLQHVRIPYYNIHPMPVHLQqrlcaEEDQGAQIYAREISALVAN---SSFDLVLLGMGADGHTASLFPQSPTGLDG 712
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTELS-----DIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  713 EQLV-VLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLpHSGQLVWYMDYDAFLG 791
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVL-HSGKTLWLLDYAAARK 232
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 26-504 1.08e-98

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 316.69  E-value: 1.08e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  26 VSIILLGATGDLAKKYLWQGLFQLYLdEAGRGHSFSFHGAALTA-PKQGQ---ELMAKALESLSCPkdmapshcAEHKDQ 101
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYC-EGLLPSEVNIVGYARSKmSDVERwkkETLARFFKRLDDR--------ECHLEQ 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 102 FLQLSQYR--QLKTAEDYQALNKDIEAQLQHAGLREAG--RIFYFSVPPFAYEDIARNINSSCRPGPGaWLRVVLEKPFG 177
Cdd:PTZ00309 126 FLKHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFG 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 178 HDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEY 257
Cdd:PTZ00309 205 RDLESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSY 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 258 GVIRDVLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRGSAVVGQY-QSYSEQVRRELQKPD-SFHSLTP 335
Cdd:PTZ00309 284 GIIRDVMQNHLLQILALLAMEKPVSL-SAEDIRDEKVKVLKCIEPIKMEECVLGQYtASADGSIPGYLEDEGvPKDSTTP 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 336 TFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNqaccvQSEKHWAAAQSQclPRQLVFHIGhgdlGSPAVLVS 415
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----VDEFRPSGDDTQ--RNELVIRAQ----PSEAMYLK 431

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 416 RNLFRPSLPSSWKEMEgppgLRLfgsplsDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAH 495
Cdd:PTZ00309 432 ITAKVPGLSNDLHQTE----LDL------TYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDR 501

                        490
                 ....*....|.
gi 108884809 496 K--APRLYPGG 504
Cdd:PTZ00309 502 GevKPEPYPFG 512
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 28-504 2.81e-88

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 287.29  E-value: 2.81e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809   28 IILLGATGDLAKKYLWQGLFQLYldEAGR-GHSFSFHGAALTaPKQGQELMAKALESLScpkDMAPSHCAEHKDQFLQLS 106
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLF--RNGLlPPDFRIVGVARR-DWSVEEFRKVVREAII---KFETDEIDEQWDEFAQRL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  107 QYR--QLKTAEDYQALNKDIEaQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFSAQ 184
Cdd:TIGR00871  79 SYVsgDVDDDESYDSLAELLE-QLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  185 QLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDVL 264
Cdd:TIGR00871 158 ELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQ-IFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMV 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  265 QNHLTEVLTLVAMELPhNVSSAEAVLRHKLQVFQALRGLQRG--SAVVGQY-----QSYSEQVRRELQKPDSfHSLTPTF 337
Cdd:TIGR00871 237 QNHLLQLLALVAMEPP-VSFDADSIRDEKVKVLKALRPIDPDdnNTVRGQYgageiGGVSVPGYLEEEGVDK-DSNTETF 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  338 AAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNqaccVQSEKHWAAAQSQCLPRQLVFHIGhgdlGSPAVLVSRN 417
Cdd:TIGR00871 315 AALKLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRD----VPSLLFKANERDANPRNALVIRIQ----PDEGVYLKFN 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  418 LFRPSLPSSWKEMEgppglrLFGSPLSDYYAYSPvrerDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLA-HK 496
Cdd:TIGR00871 387 AKKPGLNFETRPVK------LDFSYASRFGELLP----EAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAaNK 456

                         490
                  ....*....|
gi 108884809  497 APRL--YPGG 504
Cdd:TIGR00871 457 GPSPpnYPAG 466
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
558-782 1.53e-84

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 267.95  E-value: 1.53e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  558 AWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQ 637
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  638 AHLLQHVRIPYYNIHPMPVHLqqrlcAEEDQGAQIYAREISALVANSS---FDLVLLGMGADGHTASLFPQSPTGLDGEQ 714
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPASA-----ADPEEAAAAYEAELRELLPDLElpvFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  715 LVV-LTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV-GHEPKKWPISGVLPHSGQLVW 782
Cdd:pfam01182 156 LVVaVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADA---LRRAlAGDPDPLPAALVRPGAGETVW 222
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 561-784 7.51e-80

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 255.56  E-value: 7.51e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 561 EELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAhYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHL 640
Cdd:cd01400    1 EALAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDWSKVHVFLGDERCVPPDDPDSNYRLAREAL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 641 LQHVRIPYYNIHPMPVHLqqrlcaEEDQGAQIYAREISALVANS-SFDLVLLGMGADGHTASLFPQSP-TGLDGEQLVVL 718
Cdd:cd01400   80 LSHVAIPAANIHPIPTEL------GPEDAAAAYEKELRALFGGVpPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 108884809 719 TT-SPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV--GHEPKKWPISGVLPHSGQLVWYM 784
Cdd:cd01400  154 VTdSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEA---LKRAlaGPDPEELPAARVLPRPGEVLWFL 219
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 28-366 2.40e-78

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 261.16  E-value: 2.40e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  28 IILLGATGDLAKKYLWQGLFQLYLDeaGR-GHSFSFHGAALTAPKQGQ--ELMAKALESLScPKDMAPSHCaehkDQFLQ 104
Cdd:COG0364   12 LVIFGATGDLARRKLLPALYNLYRD--GLlPEGFRIIGVARRDWSDEEfrEEVREALEEFS-RKPFDEEVW----ERFLE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 105 LSQYRQL--KTAEDYQALNKDIEAQlqHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFS 182
Cdd:COG0364   85 RLHYVSGdfTDPEGYERLKELLEEL--DEERTPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDLAS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 183 AQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRD 262
Cdd:COG0364  163 ARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANA-LFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRD 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 263 VLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRG----SAVVGQY---QSYSEQV---RRELQKPDsfHS 332
Cdd:COG0364  242 MVQNHLLQLLCLVAMEPPASL-DADAIRDEKVKVLRALRPITPEdvaeNTVRGQYtagWIGGEPVpgyREEPGVAP--DS 318

                        330       340       350
                 ....*....|....*....|....*....|....
gi 108884809 333 LTPTFAAVLVHIDNLRWEGVPFILMSGKALDERV 366
Cdd:COG0364  319 TTETFVALKLEIDNWRWAGVPFYLRTGKRLPERV 352
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
228-504 1.92e-67

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 225.01  E-value: 1.92e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  228 LWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPhnVS-SAEAVLRHKLQVFQALRGLQRG 306
Cdd:pfam02781  13 LWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPP--VSfDAEDIRDEKVKVLRSLRPITPE 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  307 S----AVVGQYQSYS---EQV---RRELQKPDsfHSLTPTFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNQ 376
Cdd:pfam02781  91 DvednVVRGQYGAGWiggEPVpgyREEEGVPP--DSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEIRIQFKDV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  377 ACCVQSEKHwaaaqsQCLPRQLVFHIGHGdlgsPAVLVSRNLFRPslpsswkemeGpPGLRLFGSPLS-DYYAYSPVRER 455
Cdd:pfam02781 169 PHNLFRDPG------TLPPNELVIRIQPD----EGIYLKFNAKVP----------G-LGMRLRPVELDfSYSDRFGERIP 227

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 108884809  456 DAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHKAPRLYPGG 504
Cdd:pfam02781 228 EAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAG 276
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 560-788 8.84e-56

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 191.91  E-value: 8.84e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 560 SEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDERC-VPLSDPESNFQGL 636
Cdd:COG0363   10 AEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKegGLDWSRVHVFNLDEYVgLPPDHPQSNRRFM 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 637 QAHLLQHVRIPYYNIHPMPVHLqqrlcAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLV 716
Cdd:COG0363   90 REALLDHVDIPPENIHIPDGEA-----EDPEAAAARYEALIAEA---GGIDLQLLGIGEDGHIAFNFPGSPFLSETDRVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 717 VLTTS------------PSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV--GHEPKKWPISGVLPHSgQLVW 782
Cdd:COG0363  162 TLDEStrqanarffgsiPKVPPQAITLGIPTIMKAREILLLATGENKAEA---VAAAleGPVTEEVPASILQGHP-NVTW 237


                 ....*.
gi 108884809 783 YMDYDA 788
Cdd:COG0363  238 FLDEAA 243
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 560-788 2.86e-29

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 117.65  E-value: 2.86e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 560 SEELISKLANDIEATAVRAVRRFGQFHLALSGGSSpVALFQQLATAHYG--FPWAHTHLWLVDERCVPLSDPESNFQGLQ 637
Cdd:PLN02360  19 LDELSTDLAEYIAELSEASVKERGVFAIALSGGSL-ISFMGKLCEAPYNktVDWAKWYIFWADERVVAKNHADSNYKLAK 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 638 AHLLQHVRIPYYNIHPmpvhLQQRLCAEEdqGAQIYAREISALVANSS-----------FDLVLLGMGADGHTASLFPQS 706
Cdd:PLN02360  98 DGLLSKVPVVPSHVYS----INDTVTAEE--AATDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNH 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 707 PT-GLDGEQLVVLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTL-VSRVGHEP--KKWPISGVLPHSGQLVW 782
Cdd:PLN02360 172 PAlEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLaIDDVTEGPdaPSLPARMVQPTKGKLVW 251


                 ....*.
gi 108884809 783 YMDYDA 788
Cdd:PLN02360 252 FLDKPA 257
 
Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 556-791 4.47e-99

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 306.61  E-value: 4.47e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  556 VSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHygFPWAHTHLWLVDERCVPLSDPESNFQG 635
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQP--LDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  636 LQAHLLQHVRIPYYNIHPMPVHLQqrlcaEEDQGAQIYAREISALVAN---SSFDLVLLGMGADGHTASLFPQSPTGLDG 712
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTELS-----DIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  713 EQLV-VLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLpHSGQLVWYMDYDAFLG 791
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVL-HSGKTLWLLDYAAARK 232
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 26-504 1.08e-98

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 316.69  E-value: 1.08e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  26 VSIILLGATGDLAKKYLWQGLFQLYLdEAGRGHSFSFHGAALTA-PKQGQ---ELMAKALESLSCPkdmapshcAEHKDQ 101
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYC-EGLLPSEVNIVGYARSKmSDVERwkkETLARFFKRLDDR--------ECHLEQ 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 102 FLQLSQYR--QLKTAEDYQALNKDIEAQLQHAGLREAG--RIFYFSVPPFAYEDIARNINSSCRPGPGaWLRVVLEKPFG 177
Cdd:PTZ00309 126 FLKHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFG 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 178 HDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEY 257
Cdd:PTZ00309 205 RDLESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSY 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 258 GVIRDVLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRGSAVVGQY-QSYSEQVRRELQKPD-SFHSLTP 335
Cdd:PTZ00309 284 GIIRDVMQNHLLQILALLAMEKPVSL-SAEDIRDEKVKVLKCIEPIKMEECVLGQYtASADGSIPGYLEDEGvPKDSTTP 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 336 TFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNqaccvQSEKHWAAAQSQclPRQLVFHIGhgdlGSPAVLVS 415
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----VDEFRPSGDDTQ--RNELVIRAQ----PSEAMYLK 431

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 416 RNLFRPSLPSSWKEMEgppgLRLfgsplsDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAH 495
Cdd:PTZ00309 432 ITAKVPGLSNDLHQTE----LDL------TYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDR 501

                        490
                 ....*....|.
gi 108884809 496 K--APRLYPGG 504
Cdd:PTZ00309 502 GevKPEPYPFG 512
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 28-504 2.81e-88

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 287.29  E-value: 2.81e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809   28 IILLGATGDLAKKYLWQGLFQLYldEAGR-GHSFSFHGAALTaPKQGQELMAKALESLScpkDMAPSHCAEHKDQFLQLS 106
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLF--RNGLlPPDFRIVGVARR-DWSVEEFRKVVREAII---KFETDEIDEQWDEFAQRL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  107 QYR--QLKTAEDYQALNKDIEaQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFSAQ 184
Cdd:TIGR00871  79 SYVsgDVDDDESYDSLAELLE-QLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  185 QLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDVL 264
Cdd:TIGR00871 158 ELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQ-IFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMV 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  265 QNHLTEVLTLVAMELPhNVSSAEAVLRHKLQVFQALRGLQRG--SAVVGQY-----QSYSEQVRRELQKPDSfHSLTPTF 337
Cdd:TIGR00871 237 QNHLLQLLALVAMEPP-VSFDADSIRDEKVKVLKALRPIDPDdnNTVRGQYgageiGGVSVPGYLEEEGVDK-DSNTETF 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  338 AAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNqaccVQSEKHWAAAQSQCLPRQLVFHIGhgdlGSPAVLVSRN 417
Cdd:TIGR00871 315 AALKLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRD----VPSLLFKANERDANPRNALVIRIQ----PDEGVYLKFN 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  418 LFRPSLPSSWKEMEgppglrLFGSPLSDYYAYSPvrerDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLA-HK 496
Cdd:TIGR00871 387 AKKPGLNFETRPVK------LDFSYASRFGELLP----EAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAaNK 456

                         490
                  ....*....|
gi 108884809  497 APRL--YPGG 504
Cdd:TIGR00871 457 GPSPpnYPAG 466
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 28-502 6.83e-85

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 278.55  E-value: 6.83e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  28 IILLGATGDLAKKYLWQGLFQLYldEAGRGH-SFSFHGAALTaPKQGQELMAKALESLScpKDMAPSHCAEHKDQFLQLS 106
Cdd:PRK05722  12 LVIFGATGDLARRKLLPALYNLY--KAGLLPeDFRIIGVARR-DWSDEDFREVVREALK--EFARTPFDEEVWERFLSRL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 107 QYRQ--LKTAEDYQALNKDIEAQLQHAGLReAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFSAQ 184
Cdd:PRK05722  87 YYVSgdVTDPESYERLKELLEELDEERGTG-GNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDLASAR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 185 QLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNrkAL-DGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDV 263
Cdd:PRK05722 166 ELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFAN--ALfEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDM 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 264 LQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRG----SAVVGQYQS---YSEQV---RRELQKPDsfHSL 333
Cdd:PRK05722 244 VQNHLLQLLALVAMEPPASL-DADSIRDEKVKVLRALRPITPEdvkeNTVRGQYTAgwiGGKPVpgyREEEGVNP--DST 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 334 TPTFAAVLVHIDNLRWEGVPFILMSGKALDERVgyARIL--FKNQAccvqsekHW--AAAQSQCLPRQLVFHIghgdlgS 409
Cdd:PRK05722 321 TETFVALKLEIDNWRWAGVPFYLRTGKRLPKKV--TEIVivFKPPP-------HNlfEESAEELGPNKLVIRI------Q 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 410 P--AVLVSRNLFRPSlpsswkemegpPGLRLFGSPLS-DYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFW 486
Cdd:PRK05722 386 PdeGISLRFNAKVPG-----------EGMELRPVKLDfSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWV 454

                        490
                 ....*....|....*.
gi 108884809 487 TPLLESLAHKAPRLYP 502
Cdd:PRK05722 455 DPILEAWEADGGPPPP 470
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
558-782 1.53e-84

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 267.95  E-value: 1.53e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  558 AWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQ 637
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  638 AHLLQHVRIPYYNIHPMPVHLqqrlcAEEDQGAQIYAREISALVANSS---FDLVLLGMGADGHTASLFPQSPTGLDGEQ 714
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPASA-----ADPEEAAAAYEAELRELLPDLElpvFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  715 LVV-LTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV-GHEPKKWPISGVLPHSGQLVW 782
Cdd:pfam01182 156 LVVaVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADA---LRRAlAGDPDPLPAALVRPGAGETVW 222
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 23-375 7.39e-84

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 275.83  E-value: 7.39e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  23 QGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHSFSFHGAALTaPKQGQELMAKALESLSCPKDMApshcAEHKDQF 102
Cdd:PLN02539  15 TGCLSIIVLGASGDLAKKKTFPALFNLYRQGFLPPDEVHIFGYARS-KITDEELRDRIRGYLKDEKNAP----AEAVSKF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 103 LQLSQYRQ--LKTAEDYQALNKDI-EAQLQHAGLREAG-RIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGH 178
Cdd:PLN02539  90 LQLIKYVSgaYDSEEGFRRLDKEIsEHEISKNSAEGSSrRLFYLALPPSVYPPVCKMIKKCCMNKSGLWTRIVVEKPFGK 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 179 DHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDgLWNRHHVERVEIIMKETVDAEGRTSFYEEYG 258
Cdd:PLN02539 170 DLESAEELSSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLP-LWNRDNIANVQIVFREDFGTEGRGGYFDEYG 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 259 VIRDVLQNHLTEVLTLVAMELPhnVS-SAEAVLRHKLQVFQALRGLQRGSAVVGQYQSYseqvRRELQKPDsfHSLTPTF 337
Cdd:PLN02539 249 IIRDIIQNHLLQVLCLVAMEKP--VSlKPEHIRDEKVKVLQSVEPIKDEEVVLGQYEGY----RDDPTVPD--DSNTPTF 320

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 108884809 338 AAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKN 375
Cdd:PLN02539 321 ASVVLRINNERWEGVPFILKAGKALDSRKAEIRVQFKD 358
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 561-784 7.51e-80

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 255.56  E-value: 7.51e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 561 EELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAhYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHL 640
Cdd:cd01400    1 EALAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDWSKVHVFLGDERCVPPDDPDSNYRLAREAL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 641 LQHVRIPYYNIHPMPVHLqqrlcaEEDQGAQIYAREISALVANS-SFDLVLLGMGADGHTASLFPQSP-TGLDGEQLVVL 718
Cdd:cd01400   80 LSHVAIPAANIHPIPTEL------GPEDAAAAYEKELRALFGGVpPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 108884809 719 TT-SPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV--GHEPKKWPISGVLPHSGQLVWYM 784
Cdd:cd01400  154 VTdSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEA---LKRAlaGPDPEELPAARVLPRPGEVLWFL 219
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 28-366 2.40e-78

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 261.16  E-value: 2.40e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  28 IILLGATGDLAKKYLWQGLFQLYLDeaGR-GHSFSFHGAALTAPKQGQ--ELMAKALESLScPKDMAPSHCaehkDQFLQ 104
Cdd:COG0364   12 LVIFGATGDLARRKLLPALYNLYRD--GLlPEGFRIIGVARRDWSDEEfrEEVREALEEFS-RKPFDEEVW----ERFLE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 105 LSQYRQL--KTAEDYQALNKDIEAQlqHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFS 182
Cdd:COG0364   85 RLHYVSGdfTDPEGYERLKELLEEL--DEERTPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDLAS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 183 AQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRD 262
Cdd:COG0364  163 ARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANA-LFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRD 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 263 VLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRG----SAVVGQY---QSYSEQV---RRELQKPDsfHS 332
Cdd:COG0364  242 MVQNHLLQLLCLVAMEPPASL-DADAIRDEKVKVLRALRPITPEdvaeNTVRGQYtagWIGGEPVpgyREEPGVAP--DS 318

                        330       340       350
                 ....*....|....*....|....*....|....
gi 108884809 333 LTPTFAAVLVHIDNLRWEGVPFILMSGKALDERV 366
Cdd:COG0364  319 TTETFVALKLEIDNWRWAGVPFYLRTGKRLPERV 352
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 26-505 1.91e-77

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 261.83  E-value: 1.91e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  26 VSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHsFSFHGAALTAPKQGqELMAKALESLSCPKDMApSHCAEHKDQFLQL 105
Cdd:PLN02333 118 VSITVVGASGDLAKKKIFPALFALYYEGCLPEH-FTIFGYARSKMTDA-ELRNMVSKTLTCRIDKR-ENCGEKMEEFLKR 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 106 SQYR--QLKTAEDYQALNKDIEaqlQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGaWLRVVLEKPFGHDHFSA 183
Cdd:PLN02333 195 CFYHsgQYDSQEHFAELDKKLK---EHEGGRVSNRLFYLSIPPNIFVDAVKCASSSASSVNG-WTRVIVEKPFGRDSESS 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 184 QQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDV 263
Cdd:PLN02333 271 AALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNL-IFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDI 349

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 264 LQNHLTEVLTLVAMELPhnVS-SAEAVLRHKLQVFQALRGLQRGSAVVGQYQSYSE-QVRRELQKPDSF---HSLTPTFA 338
Cdd:PLN02333 350 MQNHLLQILALFAMETP--VSlDAEDIRNEKVKVLRSMRPIQLEDVVIGQYKSHTKgGVTYPAYTDDKTvpkGSLTPTFA 427

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 339 AVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNqaccvqsekhwaaaqsqcLPRQLVFHIGHGDLG-SPAVLVSRn 417
Cdd:PLN02333 428 AAALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRH------------------VPGNLYNRNFGTDLDqATNELVIR- 488

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 418 lFRPSLPSSWKEMEGPPGL--RLFGSPLSDYYAYSPVRE-RDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLA 494
Cdd:PLN02333 489 -VQPDEAIYLKINNKVPGLgmRLDRSNLNLLYAARYSKEiPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELE 567

                        490
                 ....*....|...
gi 108884809 495 HKA--PRLYPGGA 505
Cdd:PLN02333 568 EKKiiPEYYPYGS 580
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 18-505 8.21e-77

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 259.18  E-value: 8.21e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  18 QAQELQGHVSIILLGATGDLAKKYLWQGLFQLYLdEAGRGHSFSFHGAALTAPKQgQELMAKALESLSCPKDMApSHCAE 97
Cdd:PLN02640  81 HAEKGESTLSITVVGASGDLAKKKIFPALFALFY-EDWLPENFTVFGYARTKLTD-EELRDMISSTLTCRIDQR-ENCGD 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  98 HKDQFLQLSQYR--QLKTAEDYQALNKDIEAqlqhaglREAG----RIFYFSVPPFAYEDIARNINSSCRPGPGaWLRVV 171
Cdd:PLN02640 158 KMDQFLKRCFYHsgQYDSEEDFAELNKKLKE-------KEAGklsnRLFYLSIPPNIFVDVVRCASLRASSENG-WTRVI 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 172 LEKPFGHDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRT 251
Cdd:PLN02640 230 VEKPFGRDSESSGELTRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNL-VFEPLWSRNYIRNVQLIFSEDFGTEGRG 308

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 252 SFYEEYGVIRDVLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRGSAVVGQYQSYSEQVRRELQKPDS-- 329
Cdd:PLN02640 309 GYFDNYGIIRDIMQNHLLQILALFAMETPVSL-DAEDIRNEKVKVLRSMKPLQLEDVIVGQYKGHSKGGKSYPAYTDDpt 387

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 330 --FHSLTPTFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNQACCVQsEKHWAAAQSQClPRQLVFHIGHGDl 407
Cdd:PLN02640 388 vpKHSLTPTFAAAALFINNARWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLY-KRNFGTDLDKA-TNELVLRVQPDE- 464

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 408 gspAVLVSRNLFRPSLpsswkemegppGLRLFGSPLSDYYAYSPVRE-RDAHSVLLSHIFHGRKNFFITTENLLASWNFW 486
Cdd:PLN02640 465 ---AIYLKINNKVPGL-----------GMRLDRSDLNLLYRARYPREiPDAYERLLLDAIEGERRLFIRSDELDAAWALF 530

                        490       500
                 ....*....|....*....|.
gi 108884809 487 TPLLESLAHK--APRLYPGGA 505
Cdd:PLN02640 531 TPLLKELEEKkiIPELYPYGS 551
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
28-504 2.80e-75

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 252.51  E-value: 2.80e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  28 IILLGATGDLAKKYLWQGLFQLYLDeaGRGH-SFSFHGAALTAPKQGQ--ELMAKALESLSCPKDMAPSHcaehkDQFLQ 104
Cdd:PRK12853  11 LVIFGATGDLARRKLLPALYRLARA--GLLPeDLRIIGVGRDDWSDEQwrARVRESLRAFGADGFDDAVW-----DRLAA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 105 LSQYRQ--LKTAEDYQALNKDIEAQlqhaglreAGRIFYFSVPPFAYEDIARNINSScrpG-PGAWLRVVLEKPFGHDHF 181
Cdd:PRK12853  84 RLSYVQgdVTDPADYARLAEALGPG--------GNPVFYLAVPPSLFAPVVENLGAA---GlLPEGRRVVLEKPFGHDLA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 182 SAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIR 261
Cdd:PRK12853 153 SARALNATLAKVFDEDQIYRIDHFLGKETVQNLLALRFANA-LLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALR 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 262 DVLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGL--QRGSAVVGQYQSYS---EQVRRELQKPD-SFHSLTP 335
Cdd:PRK12853 232 DMVQNHLLQLLALVAMEPPASF-DADAVRDEKAKVLRAIRPLdpDDVHTVRGQYTAGTvggEPVPGYREEPGvDPDSRTE 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 336 TFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNQACCVQSEKHWAAaqsqclPRQLVFHIGhgdlgsPAVLVS 415
Cdd:PRK12853 311 TFVALKLEIDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPHALFRGTGVEP------PNRLVIRLQ------PDEGIS 378

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 416 RNLFRPSlpsswkemegpPGLRLFGSPLSDYYAY-SPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLA 494
Cdd:PRK12853 379 LELNVKR-----------PGPGMRLRPVELDADYaDDERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWA 447

                        490
                 ....*....|..
gi 108884809 495 --HKAPRLYPGG 504
Cdd:PRK12853 448 adPVPPHEYPAG 459
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
228-504 1.92e-67

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 225.01  E-value: 1.92e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  228 LWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPhnVS-SAEAVLRHKLQVFQALRGLQRG 306
Cdd:pfam02781  13 LWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPP--VSfDAEDIRDEKVKVLRSLRPITPE 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  307 S----AVVGQYQSYS---EQV---RRELQKPDsfHSLTPTFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNQ 376
Cdd:pfam02781  91 DvednVVRGQYGAGWiggEPVpgyREEEGVPP--DSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEIRIQFKDV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  377 ACCVQSEKHwaaaqsQCLPRQLVFHIGHGdlgsPAVLVSRNLFRPslpsswkemeGpPGLRLFGSPLS-DYYAYSPVRER 455
Cdd:pfam02781 169 PHNLFRDPG------TLPPNELVIRIQPD----EGIYLKFNAKVP----------G-LGMRLRPVELDfSYSDRFGERIP 227

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 108884809  456 DAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHKAPRLYPGG 504
Cdd:pfam02781 228 EAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAG 276
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 18-514 3.04e-63

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 219.91  E-value: 3.04e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  18 QAQELQGHVSIILLGATGDLAKKYLWQGLFqlYLDEAGRGHS-FSFHGAALtAPKQGQELMAKALESLscpkDMAPSHCA 96
Cdd:PRK12854   4 QGTGPAPPTVFVLFGATGDLAKRKLLPGLF--HLARAGLLPPdWRIVGTGR-GDVSAEAFREHARDAL----DEFGARKL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  97 EHK--DQFLQLSQYRQLK-TAEDYQALnKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSScrpGPGAWLRVVLE 173
Cdd:PRK12854  77 DDGewARFAKRLRYVPGGfLSAGPGAL-AAAVAAARAELGGDARLVHYLAVPPSAFLDVTRALGEA---GLAEGSRVVME 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 174 KPFGHDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSF 253
Cdd:PRK12854 153 KPFGTDLASAEALNAAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANG-LFEPIWNREFIDHVQIDVPETLGVDTRAAF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 254 YEEYGVIRDVLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRGSAVVGQYQSYSEQ--VRrelqkPDsfh 331
Cdd:PRK12854 232 YDATGAYRDMVVTHLFQVLAFVAMEPPTAL-EPDAISEEKNKVFRSMRPLDPAEVVRGQYSGYRDEpgVA-----PD--- 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 332 SLTPTFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNqaccvqsekhwaaaqsqclPRQLVFHIGHGDLGSPA 411
Cdd:PRK12854 303 STTETFVALKVWIDNWRWAGVPFYLRTGKRMAEGQRIISIAFRE-------------------PPYSMFPAGSVGAQGPD 363

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 412 VLVSRNLFRPSLPSSWKEMEGPPGLRLfgSPLSDYYAYSPVRER----DAHSVLLSHIFHGRKNFFITTENLLASWNFWT 487
Cdd:PRK12854 364 HLTFDLADNSKVSLSFYGKRPGPGMRL--DKLSLQFSLKDTGPKgdvlEAYERLILDALRGDHTLFTTADGIESLWEVSQ 441

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 108884809 488 PLLESlaHKAPRLYPGG-----------AENGRLLDFE 514
Cdd:PRK12854 442 PLLED--PPPVKPYAPGswgpnaihqlaAPDAWRLPFE 477
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 560-788 8.84e-56

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 191.91  E-value: 8.84e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 560 SEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDERC-VPLSDPESNFQGL 636
Cdd:COG0363   10 AEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKegGLDWSRVHVFNLDEYVgLPPDHPQSNRRFM 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 637 QAHLLQHVRIPYYNIHPMPVHLqqrlcAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLV 716
Cdd:COG0363   90 REALLDHVDIPPENIHIPDGEA-----EDPEAAAARYEALIAEA---GGIDLQLLGIGEDGHIAFNFPGSPFLSETDRVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 717 VLTTS------------PSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV--GHEPKKWPISGVLPHSgQLVW 782
Cdd:COG0363  162 TLDEStrqanarffgsiPKVPPQAITLGIPTIMKAREILLLATGENKAEA---VAAAleGPVTEEVPASILQGHP-NVTW 237


                 ....*.
gi 108884809 783 YMDYDA 788
Cdd:COG0363  238 FLDEAA 243
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
29-211 4.56e-43

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 154.12  E-value: 4.56e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809   29 ILLGATGDLAKKYLWQGLFQLYLDeaGRGH-SFSFHGAALTaPKQGQELMAKALESLSCPKDmapsHCAEHKDQFLQLSQ 107
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRD--GLLPeGFRIIGVARR-DLSDEEFRERVREALKEFKE----LDEEKWDRFLERLH 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809  108 YRQ--LKTAEDYQALNKDIEaqlQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFSAQQ 185
Cdd:pfam00479  74 YVSgdFDDPESYEKLKERLE---EHEDETRGNRLFYLAVPPSLFGPIAENLGRAGLSEEGGWRRVVIEKPFGHDLESARE 150

                         170       180
                  ....*....|....*....|....*.
gi 108884809  186 LATELGTFFQEEEMYRVDHYLGKQAV 211
Cdd:pfam00479 151 LNDQLAKVFKEEQIYRIDHYLGKETV 176
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 560-788 2.86e-29

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 117.65  E-value: 2.86e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 560 SEELISKLANDIEATAVRAVRRFGQFHLALSGGSSpVALFQQLATAHYG--FPWAHTHLWLVDERCVPLSDPESNFQGLQ 637
Cdd:PLN02360  19 LDELSTDLAEYIAELSEASVKERGVFAIALSGGSL-ISFMGKLCEAPYNktVDWAKWYIFWADERVVAKNHADSNYKLAK 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 638 AHLLQHVRIPYYNIHPmpvhLQQRLCAEEdqGAQIYAREISALVANSS-----------FDLVLLGMGADGHTASLFPQS 706
Cdd:PLN02360  98 DGLLSKVPVVPSHVYS----INDTVTAEE--AATDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNH 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 707 PT-GLDGEQLVVLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTL-VSRVGHEP--KKWPISGVLPHSGQLVW 782
Cdd:PLN02360 172 PAlEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLaIDDVTEGPdaPSLPARMVQPTKGKLVW 251


                 ....*.
gi 108884809 783 YMDYDA 788
Cdd:PLN02360 252 FLDKPA 257
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 556-771 3.03e-16

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 78.68  E-value: 3.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 556 VSAWSEELISKLandieatavraVRRFGQFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDERcVPLS--DPES 631
Cdd:cd01399    3 MSEAAAELIAEL-----------IREKPPAVLGLATGSTPLGVYEELIELHKegGLSFSNVTTFNLDEY-VGLPpdHPQS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 632 NFQGLQAHLLQHVRIPYYNIHPMPVhlqqrLCAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTAslFPQSPTGLD 711
Cdd:cd01399   71 YHYFMRENLFDHIDIKPENIHIPDG-----NAADLEAECRRYEALIAEA---GGIDLQLLGIGENGHIG--FNEPGSSLD 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 108884809 712 GE-QLVVLTTSPSQ------------PHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRVGHEP--KKWPIS 771
Cdd:cd01399  141 SRtRVVTLDESTRQanarffdgdedvPTQAITMGIGTIMKAKEILLLATGEGKAEA---VKKALEGPvtEECPAS 212
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 556-788 1.18e-09

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 59.77  E-value: 1.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 556 VSAWSEELISKLANDIEATAVRavrrfgQFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDERC-VPLSDPESN 632
Cdd:PTZ00285  12 VADYTSNYIIKRINDFKPTSDR------PFVLGLPTGSTPLPTYQELIRAYRegRVSFSNVVTFNMDEYVgLPRDHPQSY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 633 FQGLQAHLLQHVRIPYYNihpmpVHLQQRLCAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTASLFPQSPtgLDG 712
Cdd:PTZ00285  86 HYFMKENFFDHVDIKEEN-----RHILNGTAPDLEEECRRYEEKIRAV---GGIDLFLAGIGTDGHIAFNEPGSS--LDS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 713 EQLVV-LTTSP------------SQ-PHRRMSLSLPLINRAKKVAVLVMGRMKREITT--LVSRVGHepkKWPISGVLPH 776
Cdd:PTZ00285 156 RTRVKsLNQETidanarffgndiSKvPTMALTVGIRTIMEAREVLLLATGASKAIAVArcVEGGVTH---MCPASALQMH 232

                        250
                 ....*....|..
gi 108884809 777 SgQLVWYMDYDA 788
Cdd:PTZ00285 233 P-AAVLCLDEDA 243
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 585-699 3.46e-09

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 56.59  E-value: 3.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 585 FHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQRLCA 664
Cdd:cd00458   22 MVIGLGTGSTPAYFYKLLGEKLKRGEISDIVGFPTDERYVPLDSDQSNFRQAKLLAFEHDIIPASNVHYVDTSLPIEKAC 101

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 108884809 665 EEdqgaqiYAREIsaLVANSSFDLVLLGMGADGHT 699
Cdd:cd00458  102 EK------YEREI--LDQVDAIDLAVDGAGYRAGT 128
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 556-771 9.45e-08

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 54.07  E-value: 9.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 556 VSAWSEELISKLANDIEATAVRAvrrfgqFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDE-RCVPLSDPES- 631
Cdd:PRK00443  12 VGKWAARHIANRINAFLPTKERP------FVLGLATGSSPLETYKALIELHKagKVDFSRVTTFNLDEyVGLPADHPESy 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 632 -NFqgLQAHLLQHVRIPYYNIHpmpvhLQQRLCAEEDQGAQIYAREIsalVANSSFDLVLLGMGADGHTAslFPQSPTGL 710
Cdd:PRK00443  86 rYF--MRENFFDHVDIPPENIN-----LLNGNAPDPEAECRRYEEKI---KSAGGIDLQILGIGENGHIA--FNEPGSSF 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 108884809 711 DGEQLVV-LTTSPSQ-------------PHRRMSLSLPLINRAKKVAVLVMGRMKREIT--TLVSRVGHEpkkWPIS 771
Cdd:PRK00443 154 ASRTRIKtLTEDTRIansrffdgdieqvPKYALTVGVGTILDAKEIMLLAPGHNKAEAVkaAVEGPVNHM---WPAS 227
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 560-754 1.12e-06

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 52.34  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 560 SEELISKLANDIeATAVRAVRRFGQFH-LALSGGSSPVALFQQLATAH--YGFPWAHTHLWLVDERcVPLS--DPESNFQ 634
Cdd:PRK02122  36 SEEASRAVAQEI-ATLIRERQAEGKPCvLGLATGSSPIGVYAELIRMHreEGLSFKNVITFNLDEY-YPMQpdSLQSYHR 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 635 GLQAHLLQHVRIPYYNIHPMPVHLQQrlcAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTAslFPQSPTGLD-GE 713
Cdd:PRK02122 114 FMKENLFDHVDIPPENIHIPDGTIPK---EEIDEYCRDYEEKIEAA---GGIDFQLLGIGRTGHIG--FNEPGSGRNsRT 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 108884809 714 QLVVLTTS------------PSQPHRRMSLSLPLINRAKKVAVLVMGRMKREI 754
Cdd:PRK02122 186 RLVTLDHItrrdaasdffgeENVPRKAITMGVGTILKARRIVLLAWGEHKAPI 238
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
586-698 8.92e-06

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 47.82  E-value: 8.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108884809 586 HLALSGGSSPVALFQQLATAHYGFPW-AHTHLWLVDErcVPLSDPES---NFQGLQAHLLQHVRIPYYNIHPMPVhlqqr 661
Cdd:PRK12358  31 NLAITAGSTPKGMYEYLITLVKGKAWyDNVHYYNFDE--IPFRGKEGegvTITNLRNLFFTPAGIKEENIHKLTI----- 103

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 108884809 662 lcaeedqgaQIYAREISALVANSSFDLVLLGMGADGH 698
Cdd:PRK12358 104 ---------DNYREHDQKLARDGGLDLVVLGLGADGH 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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