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Conserved domains on  [gi|13124187|sp|O88662|]
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RecName: Full=Epithelial membrane protein 2; Short=EMP-2; AltName: Full=Protein XMP

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 10467089)

PMP-22/EMP/MP20 family tetraspan membrane protein similar to human claudin-9 (hCLDN-9) which is highly expressed in the inner ear, essential for hearing and a high-affinity receptor of CpE

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
1-165 7.72e-57

PMP-22/EMP/MP20/Claudin family;


:

Pssm-ID: 395662  Cd Length: 162  Bit Score: 175.64  E-value: 7.72e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13124187     1 MLVILAFIIVFHIVSTALLFISTIDNAWWVGDSF----SADLWRVCTNSTNCTEINELtgpeAFEGYSVMQAVQATMILS 76
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPDQWKVSRYVgaaaSAGLWRNCTTQSCTGQISCK----VLELNDALQAVQALMILS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13124187    77 TILSCISFLIFLLQLFRLKQGERFVLTSIIQLMSCLCVMIGASIYTDRRQDLHQQNRKlyyLLQEGSYGYSFILAWVAFA 156
Cdd:pfam00822  77 IILGIISLIVFFFQLFTMRKGGRFKLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFT---PNRKYSFGYSFILGWVAFA 153


                  ....*....
gi 13124187   157 FTFISGLMY 165
Cdd:pfam00822 154 LAFIGGVLY 162
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
1-165 7.72e-57

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 175.64  E-value: 7.72e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13124187     1 MLVILAFIIVFHIVSTALLFISTIDNAWWVGDSF----SADLWRVCTNSTNCTEINELtgpeAFEGYSVMQAVQATMILS 76
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPDQWKVSRYVgaaaSAGLWRNCTTQSCTGQISCK----VLELNDALQAVQALMILS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13124187    77 TILSCISFLIFLLQLFRLKQGERFVLTSIIQLMSCLCVMIGASIYTDRRQDLHQQNRKlyyLLQEGSYGYSFILAWVAFA 156
Cdd:pfam00822  77 IILGIISLIVFFFQLFTMRKGGRFKLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFT---PNRKYSFGYSFILGWVAFA 153


                  ....*....
gi 13124187   157 FTFISGLMY 165
Cdd:pfam00822 154 LAFIGGVLY 162
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
1-165 7.72e-57

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 175.64  E-value: 7.72e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13124187     1 MLVILAFIIVFHIVSTALLFISTIDNAWWVGDSF----SADLWRVCTNSTNCTEINELtgpeAFEGYSVMQAVQATMILS 76
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPDQWKVSRYVgaaaSAGLWRNCTTQSCTGQISCK----VLELNDALQAVQALMILS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13124187    77 TILSCISFLIFLLQLFRLKQGERFVLTSIIQLMSCLCVMIGASIYTDRRQDLHQQNRKlyyLLQEGSYGYSFILAWVAFA 156
Cdd:pfam00822  77 IILGIISLIVFFFQLFTMRKGGRFKLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFT---PNRKYSFGYSFILGWVAFA 153


                  ....*....
gi 13124187   157 FTFISGLMY 165
Cdd:pfam00822 154 LAFIGGVLY 162
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 13-165 3.01e-06

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 45.11  E-value: 3.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13124187    13 IVSTALLFISTIDNAWWVGDSFSAD------------LWRVCTNSTNCTEIN---------------ELTGPEAFEGYSV 65
Cdd:pfam13903   1 ILAFALLLIAFATDYWLVLDVALTGinnytclfahlgLWRHCFKSEVDVDSDnqtrffgclnqvpnpFPTFEEEIVSFSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13124187    66 M------QAVQATMILSTILSCISFLIFLLQLFRLKQGeRFVLTSIIQLMSCLCVMIGASIY-----------TDRRQDL 128
Cdd:pfam13903  81 TslpgltRFVQAFAILSLVLIVCGVVCGLLALPKQSVF-LLLAAGILFLLSGVLGLLGVIVFgqsvklvfeeyFRQWMPE 159

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 13124187   129 HQQNRKLyyllqegSYGYSFILAWVAFAFTFISGLMY 165
Cdd:pfam13903 160 HQNNVRI-------SFGWSFALAWAGVVLSLLAGLLF 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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