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Conserved domains on  [gi|75100641|sp|O82359|]
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RecName: Full=Sphingoid long-chain bases kinase 2, mitochondrial; Short=AtLCBK2; Short=LCB kinase 2; Flags: Precursor

Protein Classification

diacylglycerol/lipid kinase family protein( domain architecture ID 11446635)

diacylglycerol/lipid kinase family protein may catalyze the ATP-dependent phosphorylation of diacylglycerol and/or other lipids, and is involved in the phospholipid biosynthetic process

CATH:  3.40.50.10330
EC:  2.7.1.-
Gene Ontology:  GO:0008654|GO:0001727|GO:0005524|GO:0016310
SCOP:  3001940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 52-363 5.61e-78

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


:

Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 241.29  E-value: 5.61e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  52 RDLVFVVNPQGANGRTAKEWKKLLPHLRSRlgkDCNVSELLTSGPSHAIDITREAIRDGADAVIAVGGDGTLHEVVNGFf 131
Cdd:COG1597   3 MRALLIVNPASGRGRAARLLERLVAALRAA---GLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGL- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641 132 wegkpvgylsgeASRSTALGLIPLGTGSDFARTFGWNNDPCEAVERIARGMRSRIDVGVIDKegkdlHYFINVADVHLSA 211
Cdd:COG1597  79 ------------AGTGPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNG-----RYFLNVAGIGFDA 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641 212 K--AGFYASKYKKFGNLCYVIGALQAFMGHHNQDMRIRVNGGEWEIypQVTALCVGNAKYFGGGMKITPNAIPGNGNLEV 289
Cdd:COG1597 142 EvvERANRALKRRLGKLAYVLAALRALLRYRPFRLRIELDGEEIEG--EALLVAVGNGPYYGGGLRLAPDASLDDGLLDV 219

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 75100641 290 VVLQNFKWYDFVLKLHKLYNGTHLSVNNVTSRSVQSIEVEeiTDSGsIYVQSDGEHLGF-LPRKFQVLPGAIDII 363
Cdd:COG1597 220 VVVRPLSRLRLLRLLPRLLRGRHLRHPGVRYFRAREVEIE--SDRP-LPVQLDGEPLGLaTPLEFEVLPGALRVL 291
 
Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 52-363 5.61e-78

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 241.29  E-value: 5.61e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  52 RDLVFVVNPQGANGRTAKEWKKLLPHLRSRlgkDCNVSELLTSGPSHAIDITREAIRDGADAVIAVGGDGTLHEVVNGFf 131
Cdd:COG1597   3 MRALLIVNPASGRGRAARLLERLVAALRAA---GLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGL- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641 132 wegkpvgylsgeASRSTALGLIPLGTGSDFARTFGWNNDPCEAVERIARGMRSRIDVGVIDKegkdlHYFINVADVHLSA 211
Cdd:COG1597  79 ------------AGTGPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNG-----RYFLNVAGIGFDA 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641 212 K--AGFYASKYKKFGNLCYVIGALQAFMGHHNQDMRIRVNGGEWEIypQVTALCVGNAKYFGGGMKITPNAIPGNGNLEV 289
Cdd:COG1597 142 EvvERANRALKRRLGKLAYVLAALRALLRYRPFRLRIELDGEEIEG--EALLVAVGNGPYYGGGLRLAPDASLDDGLLDV 219

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 75100641 290 VVLQNFKWYDFVLKLHKLYNGTHLSVNNVTSRSVQSIEVEeiTDSGsIYVQSDGEHLGF-LPRKFQVLPGAIDII 363
Cdd:COG1597 220 VVVRPLSRLRLLRLLPRLLRGRHLRHPGVRYFRAREVEIE--SDRP-LPVQLDGEPLGLaTPLEFEVLPGALRVL 291
PRK13057 PRK13057
lipid kinase;
56-363 4.28e-43

lipid kinase;


Pssm-ID: 183857 [Multi-domain]  Cd Length: 287  Bit Score: 150.84  E-value: 4.28e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   56 FVVNPQGANGRTAkewkklLPHLRSRL-GKDCNVSELLTSGPSHAIDITReAIRDGADAVIAVGGDGTLHEVVNGFFWEG 134
Cdd:PRK13057   2 LLVNRHARSGRAA------LAAARAALeAAGLELVEPPAEDPDDLSEVIE-AYADGVDLVIVGGGDGTLNAAAPALVETG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  135 KPvgylsgeasrstaLGLIPLGTGSDFARTFGWNNDPCEAVERIARGMRSRIDVGVIDKegkdlHYFINVADVHLSAK-A 213
Cdd:PRK13057  75 LP-------------LGILPLGTANDLARTLGIPLDLEAAARVIATGQVRRIDLGWVNG-----HYFFNVASLGLSAElA 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  214 GFYASKYKK-FGNLCYVIGALQAFMGHHNQDMRIRVNGGEWEIypQVTALCVGNAKYFGGGMKITPNAIPGNGNLEVVVL 292
Cdd:PRK13057 137 RRLTKELKRrWGTLGYAIAALRVLRRSRPFTAEIEHDGRTERV--KTLQVAVGNGRYYGGGMTVAHDATIDDGRLDLYSL 214

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75100641  293 QNFKWYDFVLKLHKLYNGTHLSVNNVTSRSVQSIEVEeiTDSgSIYVQSDGEHLGFLPRKFQVLPGAIDII 363
Cdd:PRK13057 215 EVAHWWRLLALLPALRRGRHGEWPDVRAFRTTELELR--TRK-PRPINTDGELTTYTPAHFRVLPKALRVL 282
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 54-191 7.75e-39

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 134.64  E-value: 7.75e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641    54 LVFVVNPQGANGRTAKEWKKLLPHLRSRLgkdCNVSELLTSGPSHAIDITREAIRDGADAVIAVGGDGTLHEVVNGFFWE 133
Cdd:pfam00781   2 LLVIVNPKSGGGKGKKLLRKVRPLLNKAG---VEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 75100641   134 GKPvgylsgeasrsTALGLIPLGTGSDFARTFGWNNDPCEAVERIARGMRSRIDVGVI 191
Cdd:pfam00781  79 ATR-----------PPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 56-362 5.36e-37

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 135.32  E-value: 5.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641    56 FVVNPQGANGRTAKEWKKLLPHLRSRLgkdcnvSELLTSGPSHAIDITR---EAIRDGADAVIAVGGDGTLHEVVNGFfw 132
Cdd:TIGR00147   6 AILNPTAGKSNDNKPLREVIMLLREEG------MEIHVRVTWEKGDAARyveEARKFGVDTVIAGGGDGTINEVVNAL-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   133 egKPVgylsgeaSRSTALGLIPLGTGSDFARTFGWNNDPCEAVERIARGMRSRIDVGVIDkegkDLHYFINVADVHLSAK 212
Cdd:TIGR00147  78 --IQL-------DDIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVN----KQYCFINMAGGGFGTE 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   213 AGF-YASKYK-KFGNLCYVIGALQAFMGHHNQDMRIRVNGGEWEiyPQVTALCVGNAKYFGGGMKITPNAIPGNGNLEVV 290
Cdd:TIGR00147 145 ITTeTPEKLKaALGSLSYILSGLMRMDTLQPFRCEIRGEGEHWQ--GEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLR 222

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75100641   291 VLQNFKWYDFVLKLHKLYNGTHLSVNNVTSRSVQSIEVEEITDsgsIYVQSDGEHLGFLPRKFQVLPGAIDI 362
Cdd:TIGR00147 223 IFTNDNLLPALVLTLMSDEGKHTDNPNIIYGKASRIDIQTPHK---ITFNLDGEPLGGTPFHIEILPAHLRC 291
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 54-171 3.17e-13

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 65.78  E-value: 3.17e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641     54 LVFVvNPQGANGRTakewKKLLPHLRSRLGKDCnVSELLTSGPSHAIDITREAIRDGAdaVIAVGGDGTLHEVVNGFfwe 133
Cdd:smart00046   1 LVFV-NPKSGGGKG----EKLLRKFRLLLNPRQ-VFDLTKKGPAVALVIFRDVPDFNR--VLVCGGDGTVGWVLNAL--- 69

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 75100641    134 gkpvgyLSGE-ASRSTALGLIPLGTGSDFARTFGWNNDP 171
Cdd:smart00046  70 ------DKRElPLPEPPVAVLPLGTGNDLARSLGWGGGY 102
 
Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 52-363 5.61e-78

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 241.29  E-value: 5.61e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  52 RDLVFVVNPQGANGRTAKEWKKLLPHLRSRlgkDCNVSELLTSGPSHAIDITREAIRDGADAVIAVGGDGTLHEVVNGFf 131
Cdd:COG1597   3 MRALLIVNPASGRGRAARLLERLVAALRAA---GLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGL- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641 132 wegkpvgylsgeASRSTALGLIPLGTGSDFARTFGWNNDPCEAVERIARGMRSRIDVGVIDKegkdlHYFINVADVHLSA 211
Cdd:COG1597  79 ------------AGTGPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNG-----RYFLNVAGIGFDA 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641 212 K--AGFYASKYKKFGNLCYVIGALQAFMGHHNQDMRIRVNGGEWEIypQVTALCVGNAKYFGGGMKITPNAIPGNGNLEV 289
Cdd:COG1597 142 EvvERANRALKRRLGKLAYVLAALRALLRYRPFRLRIELDGEEIEG--EALLVAVGNGPYYGGGLRLAPDASLDDGLLDV 219

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 75100641 290 VVLQNFKWYDFVLKLHKLYNGTHLSVNNVTSRSVQSIEVEeiTDSGsIYVQSDGEHLGF-LPRKFQVLPGAIDII 363
Cdd:COG1597 220 VVVRPLSRLRLLRLLPRLLRGRHLRHPGVRYFRAREVEIE--SDRP-LPVQLDGEPLGLaTPLEFEVLPGALRVL 291
PRK13057 PRK13057
lipid kinase;
56-363 4.28e-43

lipid kinase;


Pssm-ID: 183857 [Multi-domain]  Cd Length: 287  Bit Score: 150.84  E-value: 4.28e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   56 FVVNPQGANGRTAkewkklLPHLRSRL-GKDCNVSELLTSGPSHAIDITReAIRDGADAVIAVGGDGTLHEVVNGFFWEG 134
Cdd:PRK13057   2 LLVNRHARSGRAA------LAAARAALeAAGLELVEPPAEDPDDLSEVIE-AYADGVDLVIVGGGDGTLNAAAPALVETG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  135 KPvgylsgeasrstaLGLIPLGTGSDFARTFGWNNDPCEAVERIARGMRSRIDVGVIDKegkdlHYFINVADVHLSAK-A 213
Cdd:PRK13057  75 LP-------------LGILPLGTANDLARTLGIPLDLEAAARVIATGQVRRIDLGWVNG-----HYFFNVASLGLSAElA 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  214 GFYASKYKK-FGNLCYVIGALQAFMGHHNQDMRIRVNGGEWEIypQVTALCVGNAKYFGGGMKITPNAIPGNGNLEVVVL 292
Cdd:PRK13057 137 RRLTKELKRrWGTLGYAIAALRVLRRSRPFTAEIEHDGRTERV--KTLQVAVGNGRYYGGGMTVAHDATIDDGRLDLYSL 214

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75100641  293 QNFKWYDFVLKLHKLYNGTHLSVNNVTSRSVQSIEVEeiTDSgSIYVQSDGEHLGFLPRKFQVLPGAIDII 363
Cdd:PRK13057 215 EVAHWWRLLALLPALRRGRHGEWPDVRAFRTTELELR--TRK-PRPINTDGELTTYTPAHFRVLPKALRVL 282
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 54-191 7.75e-39

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 134.64  E-value: 7.75e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641    54 LVFVVNPQGANGRTAKEWKKLLPHLRSRLgkdCNVSELLTSGPSHAIDITREAIRDGADAVIAVGGDGTLHEVVNGFFWE 133
Cdd:pfam00781   2 LLVIVNPKSGGGKGKKLLRKVRPLLNKAG---VEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 75100641   134 GKPvgylsgeasrsTALGLIPLGTGSDFARTFGWNNDPCEAVERIARGMRSRIDVGVI 191
Cdd:pfam00781  79 ATR-----------PPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 56-362 5.36e-37

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 135.32  E-value: 5.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641    56 FVVNPQGANGRTAKEWKKLLPHLRSRLgkdcnvSELLTSGPSHAIDITR---EAIRDGADAVIAVGGDGTLHEVVNGFfw 132
Cdd:TIGR00147   6 AILNPTAGKSNDNKPLREVIMLLREEG------MEIHVRVTWEKGDAARyveEARKFGVDTVIAGGGDGTINEVVNAL-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   133 egKPVgylsgeaSRSTALGLIPLGTGSDFARTFGWNNDPCEAVERIARGMRSRIDVGVIDkegkDLHYFINVADVHLSAK 212
Cdd:TIGR00147  78 --IQL-------DDIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVN----KQYCFINMAGGGFGTE 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   213 AGF-YASKYK-KFGNLCYVIGALQAFMGHHNQDMRIRVNGGEWEiyPQVTALCVGNAKYFGGGMKITPNAIPGNGNLEVV 290
Cdd:TIGR00147 145 ITTeTPEKLKaALGSLSYILSGLMRMDTLQPFRCEIRGEGEHWQ--GEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLR 222

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75100641   291 VLQNFKWYDFVLKLHKLYNGTHLSVNNVTSRSVQSIEVEEITDsgsIYVQSDGEHLGFLPRKFQVLPGAIDI 362
Cdd:TIGR00147 223 IFTNDNLLPALVLTLMSDEGKHTDNPNIIYGKASRIDIQTPHK---ITFNLDGEPLGGTPFHIEILPAHLRC 291
PRK11914 PRK11914
diacylglycerol kinase; Reviewed
 57-364 1.59e-30

diacylglycerol kinase; Reviewed


Pssm-ID: 237021 [Multi-domain]  Cd Length: 306  Bit Score: 117.96  E-value: 1.59e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   57 VVNPQGANGRTAKEWKKLLPHLRSRlGKDcnVSELLTSGPSHAIDITREAIRDGADAVIAVGGDGTlheVVNGffwegkp 136
Cdd:PRK11914  14 LTNPLSGHGAAPHAAERAIARLHHR-GVD--VVEIVGTDAHDARHLVAAALAKGTDALVVVGGDGV---ISNA------- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  137 vgyLSGEASRSTALGLIPLGTGSDFARTFGW-NNDPCEAVERIARGMRSRIDVGVIDKEGKDLHYFINVADVHLSAKAGF 215
Cdd:PRK11914  81 ---LQVLAGTDIPLGIIPAGTGNDHAREFGIpTGDPEAAADVIVDGWTETVDLGRIQDDDGIVKWFGTVAATGFDSLVTD 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  216 YASKYK-KFGNLCYVIGALQAFMGHHNQDMRIRVNGGEwEIYPQVTALCVGNAKYFGGGMKITPNAIPGNGNLEVVVLQN 294
Cdd:PRK11914 158 RANRMRwPHGRMRYNLAMLAELSKLRPLPFRLVLDGTE-EIVTDLTLAAFGNTRSYGGGMLICPNADHTDGLLDITMVQS 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  295 FKWYDFVLKLHKLYNGTHLSVNNVTSRSVQSIEVEeitdSGSIYVQSDGEHLGFLPRKFQVLPGAIDIIS 364
Cdd:PRK11914 237 ASRTRLLRLFPTVFKGTHVELDEVSTARAKTVHVE----CPGINAYADGDFACPLPAEISAVPGALQILR 302
PRK13054 PRK13054
lipid kinase; Reviewed
 104-360 6.57e-28

lipid kinase; Reviewed


Pssm-ID: 237281 [Multi-domain]  Cd Length: 300  Bit Score: 110.73  E-value: 6.57e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  104 REAIRDGADAVIAVGGDGTLHEVVNGFfwegkpvgyLSGEASRSTALGLIPLGTGSDFARTFGWNNDPCEAVERIARGMR 183
Cdd:PRK13054  50 EEALALGVATVIAGGGDGTINEVATAL---------AQLEGDARPALGILPLGTANDFATAAGIPLEPDKALKLAIEGRA 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  184 SRIDVGVIDkegkDLHYFINVadvhlsAKAGFYA-------SKYKKF-GNLCYVIGALQAFMGHHNQDMRIRVNGGEWEi 255
Cdd:PRK13054 121 QPIDLARVN----DRTYFINM------ATGGFGTrvttetpEKLKAAlGGVAYLIHGLMRMDTLKPDRCEIRGPDFHWQ- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  256 yPQVTALCVGNAKYFGGGMKITPNAIPGNGNLEVVVlqnFKWYDFVLK--LHKLYNGTHLSvNNVTSRSVQSIEVEEITD 333
Cdd:PRK13054 190 -GDALVIGIGNGRQAGGGQQLCPEALINDGLLDLRI---LPAPQELLPtlLSTLTGGSEDN-PNIIRARLPWLEIQAPHE 264

                        250       260
                 ....*....|....*....|....*..
gi 75100641  334 sgsIYVQSDGEHLGFLPRKFQVLPGAI 360
Cdd:PRK13054 265 ---LTFNLDGEPLSGRHFRIEVLPAAL 288
PRK13055 PRK13055
putative lipid kinase; Reviewed
 93-363 1.62e-25

putative lipid kinase; Reviewed


Pssm-ID: 237282 [Multi-domain]  Cd Length: 334  Bit Score: 105.07  E-value: 1.62e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   93 TSGPSHAIDITREAIRDGADAVIAVGGDGTLHEVVNGffwegkpvgyLSGEASRSTaLGLIPLGTGSDFARTFGW-NNDP 171
Cdd:PRK13055  42 TPEPNSAKNEAKRAAEAGFDLIIAAGGDGTINEVVNG----------IAPLEKRPK-MAIIPAGTTNDYARALKIpRDNP 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  172 CEAVERIARGMRSRIDVGVIDKEgkdlHYFINVAdvhlsakAG------FYA--SKYK-KFGNLCYVIGALQAFMGHHNQ 242
Cdd:PRK13055 111 VEAAKVILKNQTIKMDIGRANED----KYFINIA-------AGgsltelTYSvpSQLKsMFGYLAYLAKGAELLPRVSPV 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  243 DMRIRVNGGEWEiyPQVTALCVGNAKYFGGGMKITPNAIPGNGNLEVVVLQN---FKWYDFVLKLhkLYNGTHLSVNNVT 319
Cdd:PRK13055 180 PVRITYDEGVFE--GKISMFFLALTNSVGGFEQIVPDAKLDDGKFTLIIVKTanlFELLHLMALI--LNGGKHIDDPRVI 255

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 75100641  320 SRSVQSIEVEEITDSgSIYVQSDGEHLGFLPRKFQVLPGAIDII 363
Cdd:PRK13055 256 YIKTSKLTIEPLGDD-RLMVNLDGEYGGDAPMTFENLKQHIEFF 298
PRK13337 PRK13337
putative lipid kinase; Reviewed
 72-364 6.33e-25

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 102.82  E-value: 6.33e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   72 KKLLPHLRSRLGK-DCNVSELLTSGPSHAIDITREAIRDGADAVIAVGGDGTLHEVVNGffwegkpvgyLSGEASRSTaL 150
Cdd:PRK13337  18 KKNLPDVLQKLEQaGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNG----------IAEKENRPK-L 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  151 GLIPLGTGSDFARTFGWNNDPCEAVERIARGMRSRIDVGVIDKegkdlHYFINVAD----VHLSAKAgfyASKYKKF-GN 225
Cdd:PRK13337  87 GIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKANN-----RYFINIAGggrlTELTYEV---PSKLKTMlGQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  226 LCYVIGALQAFMGHHNQDMRIRVNGGEWEiyPQVTALCVGNAKYFGGGMKITPNAIPGNGNLEVVVLQNFKWYDFVLKLH 305
Cdd:PRK13337 159 LAYYLKGIEMLPSLKATDVRIEYDGKLFQ--GEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKANLAELIHIAT 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 75100641  306 KLYNGTHLSVNNVTSRSVQSIEVEEITDsgsIYVQSDGEHLGFLPRKFQVLPGAIDIIS 364
Cdd:PRK13337 237 LALRGEHIKHPKVIYTKANRIKVSSFDK---MQLNLDGEYGGKLPAEFENLYRHIEVFV 292
YegS_C pfam19279
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ...
 223-363 1.40e-22

YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.


Pssm-ID: 437111  Cd Length: 158  Bit Score: 92.65  E-value: 1.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   223 FGNLCYVIGALQAFMGHHNQDMRIRVNGGEWEiYPQVTALcVGNAKYFGGGMKITPNAIPGNGNLEVVVLQNFKWYDFVL 302
Cdd:pfam19279  22 PGALSYPAAALRALATFRPLRYRVTVDGEVRE-FSAALVA-VANSGYYGGGMRIAPDARVDDGLLDVVVIEAASRRTLLR 99

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75100641   303 KLHKLYNGTHLS---VNNVTSRSVqsieveEITDSGSIYVQSDGEHLGFLPRKFQVLPGAIDII 363
Cdd:pfam19279 100 LLPKVYDGRHVRlpqVEVLRGREV------RIEADRPLPAGADGEVLGPLPVRVEVLPGALRVL 157
PRK12361 PRK12361
hypothetical protein; Provisional
 57-294 8.46e-14

hypothetical protein; Provisional


Pssm-ID: 183473 [Multi-domain]  Cd Length: 547  Bit Score: 72.35  E-value: 8.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   57 VVNPQGANGRtakeWKKLLPHLRSRLGKDCNVSELLTSGPSHAIDITREAIRDGADAVIAVGGDGTLHEVVngffwegkp 136
Cdd:PRK12361 248 IANPVSGGGK----WQEYGEQIQRELKAYFDLTVKLTTPEISAEALAKQARKAGADIVIACGGDGTVTEVA--------- 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  137 vgylSGEASRSTALGLIPLGTGSDFART-FGWNND--PCE-AVERIARGMRSRIDVGVIDKegkdlHYFINVADVHLSAK 212
Cdd:PRK12361 315 ----SELVNTDITLGIIPLGTANALSHAlFGLGSKliPVEqACDNIIQGHTQRIDTARCND-----RLMLLLVGIGFEQK 385

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  213 AGFYASKYKK--FGNLCYVIGALQAFMGHHNQDMRIRVNGGEweiyPQ---VTALCVGNAKYF------GGGmkiTPNai 281
Cdd:PRK12361 386 MIESADRERKnaLGQLAYLDGLWRAVNENETLTLTVTLDDAE----PQtisTHSLVVANAAPFtsllaqGGG---EPN-- 456

                        250
                 ....*....|...
gi 75100641  282 PGNGNLEVVVLQN 294
Cdd:PRK12361 457 MTDGLLDITWLDS 469
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 54-171 3.17e-13

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 65.78  E-value: 3.17e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641     54 LVFVvNPQGANGRTakewKKLLPHLRSRLGKDCnVSELLTSGPSHAIDITREAIRDGAdaVIAVGGDGTLHEVVNGFfwe 133
Cdd:smart00046   1 LVFV-NPKSGGGKG----EKLLRKFRLLLNPRQ-VFDLTKKGPAVALVIFRDVPDFNR--VLVCGGDGTVGWVLNAL--- 69

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 75100641    134 gkpvgyLSGE-ASRSTALGLIPLGTGSDFARTFGWNNDP 171
Cdd:smart00046  70 ------DKRElPLPEPPVAVLPLGTGNDLARSLGWGGGY 102
PRK00861 PRK00861
putative lipid kinase; Reviewed
 52-364 1.15e-11

putative lipid kinase; Reviewed


Pssm-ID: 234850 [Multi-domain]  Cd Length: 300  Bit Score: 64.64  E-value: 1.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   52 RDLVFVVNPQGANGRTAKEwkklLPHLRSRLGKDCNVSELLTSGPSHAIDITREAIRDGADAVIAVGGDGTLHEVvngff 131
Cdd:PRK00861   3 RSACLIFNPVAGQGNPEVD----LALIRAILEPEMDLDIYLTTPEIGADQLAQEAIERGAELIIASGGDGTLSAV----- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  132 wegkpVGYLSGEasrSTALGLIPLGTGSDFARTFGWNNDPCEAVERIARGMRSRIDVGVIDkeGKDLhyfINVADVHLSA 211
Cdd:PRK00861  74 -----AGALIGT---DIPLGIIPRGTANAFAAALGIPDTIEEACRTILQGKTRRVDVAYCN--GQPM---ILLAGIGFEA 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  212 KAGFYASKYKK--FGNLCYVIGALQAFMGHHNQDMRIRVngGEWEIYPQVTALCVGN--------AKYFGGgmkitpnAI 281
Cdd:PRK00861 141 ETVEEADREAKnrFGILAYILSGLQQLRELESFEVEIET--EDQIITTNAVAVTVANaapptsvlAQGPGA-------VI 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  282 PGNGNLEV-VVLQNFKWYDFVLKLHKLynGTHLSVNNVTSRSVQSIEVEEI---TDSGSiYVQSDGEHLGFLPRKFQVLP 357
Cdd:PRK00861 212 PDDGLLDVtIVAPKNLAEAVAASYHLL--QTALQGNPAERDDIGYLRAKQVkitTDPPQ-KVVIDGEVVGTTPIEIECLP 288


                 ....*..
gi 75100641  358 GAIDIIS 364
Cdd:PRK00861 289 RSLKVFA 295
PRK13059 PRK13059
putative lipid kinase; Reviewed
 98-362 6.58e-11

putative lipid kinase; Reviewed


Pssm-ID: 183858  Cd Length: 295  Bit Score: 62.36  E-value: 6.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   98 HAIDITREAIRDGADAVIAVGGDGTLHEVVNgffwegkpvgyLSGEASRSTALGLIPLGTGSDFARTFGWNNDPCEAVER 177
Cdd:PRK13059  44 YDLKNAFKDIDESYKYILIAGGDGTVDNVVN-----------AMKKLNIDLPIGILPVGTANDFAKFLGMPTDIGEACEQ 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  178 IARGMRSRIDVGVIDKEgkdlhYFINVA------DVHLSAKAGFyaskYKKFGNLCYVIGALQAFMGHHNQDMRIRVNGG 251
Cdd:PRK13059 113 ILKSKPKKVDLGKINDK-----YFINVAstglftDVSQKTDVNL----KNTIGKLAYYLKGLEELPNFRKLKVKVTSEEV 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  252 --EWEIYpqvtALCVGNAKYfGGGMKITPNAIPGNGNLEVVVLQNFKWYDFVLKLHKLYNGTHL-SVNNVTSRSVQSIEV 328
Cdd:PRK13059 184 nfDGDMY----LMLVFNGQT-AGNFNLAYKAEVDDGLLDVIIIKACPIIDLIPLFIKVLKGEHLeDVNGLIYFKTDKLEI 258

                        250       260       270
                 ....*....|....*....|....*....|....
gi 75100641  329 EEitdSGSIYVQSDGEHLGFLPRKFQVLPGAIDI 362
Cdd:PRK13059 259 ES---NEEIVTDIDGERGPDFPLNIECIKGGLKV 289
PLN02958 PLN02958
diacylglycerol kinase/D-erythro-sphingosine kinase
 52-191 5.61e-06

diacylglycerol kinase/D-erythro-sphingosine kinase


Pssm-ID: 215517 [Multi-domain]  Cd Length: 481  Bit Score: 47.93  E-value: 5.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   52 RDLVFVvNPQGANgrtaKEWKKLLPHLRSRLGKDCNVSELL--TSGPSHAIDITREAIRDGADAVIAVGGDGTLHEVVNG 129
Cdd:PLN02958 113 RLLVFV-NPFGGK----KSASKIFFDVVKPLLEDADIQLTIqeTKYQLHAKEVVRTMDLSKYDGIVCVSGDGILVEVVNG 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641  130 FF----WegkpvgylsgEASRSTALGLIPLGTGSDFAR-TFGWNNDPCE---AVERIARGMRSRIDVGVI 191
Cdd:PLN02958 188 LLeredW----------KTAIKLPIGMVPAGTGNGMAKsLLDSVGEPCSatnAVLAIIRGHKCSLDVATI 247
PLN02204 PLN02204
diacylglycerol kinase
 52-130 1.93e-04

diacylglycerol kinase


Pssm-ID: 215126 [Multi-domain]  Cd Length: 601  Bit Score: 43.34  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75100641   52 RDLVFVVNPQGANGRTAKEWKKLLP-HLRSRLgkdcNVSELLTSGPSHAIDiTREAIRD----GADAVIAVGGDGTLHEV 126
Cdd:PLN02204 160 KNLLVFVHPLSGKGSGSRTWETVSPiFIRAKV----KTKVIVTERAGHAFD-VMASISNkelkSYDGVIAVGGDGFFNEI 234


                 ....
gi 75100641  127 VNGF 130
Cdd:PLN02204 235 LNGY 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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