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Conserved domains on  [gi|317373289|sp|O76024|]
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RecName: Full=Wolframin

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WC-rich pfam20053
Wolframin cysteine-rich domain; Located N-terminal to the wolframin OB-fold domain, this ...
 666-769 5.08e-51

Wolframin cysteine-rich domain; Located N-terminal to the wolframin OB-fold domain, this region could represent an extension to the core of the OB fold domain. The observed conserved cysteine residues could contribute to disulfide-bond-mediated cross-linking in calcium-stores regulation.


:

Pssm-ID: 466275  Cd Length: 106  Bit Score: 174.06  E-value: 5.08e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373289  666 WQQYGALCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTDIDNSAESAINMLPFFIGDWMRCLYGEAYPA-CSP 744
Cdd:pfam20053   1 WEQYQNLCGQPAWEESNKAQTQIRCSHLEGHKVNWEGYVKNVRIKSIENSAESVLNYLPVFLADWLRCLYGEPYPEdCDK 80

                          90       100
                  ....*....|....*....|....*.
gi 317373289  745 GNTSTAEE-ELCRLKLLAKHPCHIKK 769
Cdd:pfam20053  81 FLLSVQEEeELCRLKKLAKNKCHLKR 106
WCOB pfam19913
Wolframin C-terminal OB-fold domain; OB fold domain found at the C-terminus of the wolframin ...
 770-876 1.13e-29

Wolframin C-terminal OB-fold domain; OB fold domain found at the C-terminus of the wolframin protein. Localizes to the ER lumen and lacks the conserved polar residues typical of OB-fold domain-mediated nucleic acid-binding. Predicted to mediate protein-protein interactions.


:

Pssm-ID: 437745  Cd Length: 120  Bit Score: 113.94  E-value: 1.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373289  770 FDRYKFEITVGMPFSSGadgsrsreeDDVTKDIVLRASSEFKSVLLSLRQGSLIEFSTILEG-RLGSKWPVFELKAISCL 848
Cdd:pfam19913   1 WNRYTFEVTVKMPSGGW---------LDRTADIILKADHEFKNFTLSLRPGDKVRFSGTLEGyRLGSKDPQLELKEIECL 71

                          90       100
                  ....*....|....*....|....*...
gi 317373289  849 NCMAQLSPTRRHVKIEHDWRSTVHGAVK 876
Cdd:pfam19913  72 DCKSSLLTASRKRKIERDWRGTLKDILR 99
WEF-hand pfam19914
Wolframin EF-hand domain; Contains two characteriztic copies of the bihelical repeat forming ...
 176-255 2.50e-28

Wolframin EF-hand domain; Contains two characteriztic copies of the bihelical repeat forming the basic EF-hand unit. The absence of the characteriztic calcium-binding motif, suggesting it could self-dimerize or dimerize with other EF-hand-containing proteins.


:

Pssm-ID: 466231  Cd Length: 80  Bit Score: 108.82  E-value: 2.50e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373289  176 VRKAALVMYWKLNpKKKKQVAVAELLENVGQVNEHDGGAQPGPVPKSL-QKQRRMLERLVSSESKNYIALDDFVEITKKY 254
Cdd:pfam19914   1 ARKAAREMFASLS-NGKEFITVSQLLRNMREINATDGGSRREPGPGSTsNKSRKVLESLVSSESDRFITEDDLVSAAKKY 79


                  .
gi 317373289  255 A 255
Cdd:pfam19914  80 A 80
WSLR pfam20023
Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This ...
 137-175 3.58e-10

Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This region has been linked to calmodulin-binding, suggesting these repeats may mediate a protein interaction.


:

Pssm-ID: 466262  Cd Length: 39  Bit Score: 55.63  E-value: 3.58e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 317373289  137 GRREAVKLLRRCLADRRGITSENEREVRQLSSETDLERA 175
Cdd:pfam20023   1 GHEAATELLKHCLETGKGITEENEEEVNSCLAVSWLEKA 39
WSLR pfam20023
Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This ...
 99-133 1.17e-07

Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This region has been linked to calmodulin-binding, suggesting these repeats may mediate a protein interaction.


:

Pssm-ID: 466262  Cd Length: 39  Bit Score: 48.70  E-value: 1.17e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 317373289   99 DPKAQTEVGKHYLQ----LAGDTDEELNSCTAVDWLVLA 133
Cdd:pfam20023   1 GHEAATELLKHCLEtgkgITEENEEEVNSCLAVSWLEKA 39
 
Name Accession Description Interval E-value
WC-rich pfam20053
Wolframin cysteine-rich domain; Located N-terminal to the wolframin OB-fold domain, this ...
 666-769 5.08e-51

Wolframin cysteine-rich domain; Located N-terminal to the wolframin OB-fold domain, this region could represent an extension to the core of the OB fold domain. The observed conserved cysteine residues could contribute to disulfide-bond-mediated cross-linking in calcium-stores regulation.


Pssm-ID: 466275  Cd Length: 106  Bit Score: 174.06  E-value: 5.08e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373289  666 WQQYGALCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTDIDNSAESAINMLPFFIGDWMRCLYGEAYPA-CSP 744
Cdd:pfam20053   1 WEQYQNLCGQPAWEESNKAQTQIRCSHLEGHKVNWEGYVKNVRIKSIENSAESVLNYLPVFLADWLRCLYGEPYPEdCDK 80

                          90       100
                  ....*....|....*....|....*.
gi 317373289  745 GNTSTAEE-ELCRLKLLAKHPCHIKK 769
Cdd:pfam20053  81 FLLSVQEEeELCRLKKLAKNKCHLKR 106
WCOB pfam19913
Wolframin C-terminal OB-fold domain; OB fold domain found at the C-terminus of the wolframin ...
 770-876 1.13e-29

Wolframin C-terminal OB-fold domain; OB fold domain found at the C-terminus of the wolframin protein. Localizes to the ER lumen and lacks the conserved polar residues typical of OB-fold domain-mediated nucleic acid-binding. Predicted to mediate protein-protein interactions.


Pssm-ID: 437745  Cd Length: 120  Bit Score: 113.94  E-value: 1.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373289  770 FDRYKFEITVGMPFSSGadgsrsreeDDVTKDIVLRASSEFKSVLLSLRQGSLIEFSTILEG-RLGSKWPVFELKAISCL 848
Cdd:pfam19913   1 WNRYTFEVTVKMPSGGW---------LDRTADIILKADHEFKNFTLSLRPGDKVRFSGTLEGyRLGSKDPQLELKEIECL 71

                          90       100
                  ....*....|....*....|....*...
gi 317373289  849 NCMAQLSPTRRHVKIEHDWRSTVHGAVK 876
Cdd:pfam19913  72 DCKSSLLTASRKRKIERDWRGTLKDILR 99
WEF-hand pfam19914
Wolframin EF-hand domain; Contains two characteriztic copies of the bihelical repeat forming ...
 176-255 2.50e-28

Wolframin EF-hand domain; Contains two characteriztic copies of the bihelical repeat forming the basic EF-hand unit. The absence of the characteriztic calcium-binding motif, suggesting it could self-dimerize or dimerize with other EF-hand-containing proteins.


Pssm-ID: 466231  Cd Length: 80  Bit Score: 108.82  E-value: 2.50e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373289  176 VRKAALVMYWKLNpKKKKQVAVAELLENVGQVNEHDGGAQPGPVPKSL-QKQRRMLERLVSSESKNYIALDDFVEITKKY 254
Cdd:pfam19914   1 ARKAAREMFASLS-NGKEFITVSQLLRNMREINATDGGSRREPGPGSTsNKSRKVLESLVSSESDRFITEDDLVSAAKKY 79


                  .
gi 317373289  255 A 255
Cdd:pfam19914  80 A 80
WSLR pfam20023
Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This ...
 137-175 3.58e-10

Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This region has been linked to calmodulin-binding, suggesting these repeats may mediate a protein interaction.


Pssm-ID: 466262  Cd Length: 39  Bit Score: 55.63  E-value: 3.58e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 317373289  137 GRREAVKLLRRCLADRRGITSENEREVRQLSSETDLERA 175
Cdd:pfam20023   1 GHEAATELLKHCLETGKGITEENEEEVNSCLAVSWLEKA 39
WSLR pfam20023
Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This ...
 99-133 1.17e-07

Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This region has been linked to calmodulin-binding, suggesting these repeats may mediate a protein interaction.


Pssm-ID: 466262  Cd Length: 39  Bit Score: 48.70  E-value: 1.17e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 317373289   99 DPKAQTEVGKHYLQ----LAGDTDEELNSCTAVDWLVLA 133
Cdd:pfam20023   1 GHEAATELLKHCLEtgkgITEENEEEVNSCLAVSWLEKA 39
TPR COG0790
TPR repeat [General function prediction only];
95-179 1.39e-04

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 44.53  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373289  95 AKAGDPKAQTEVGKHYLQLAG-DTDEELnsctAVDWLVLAAKQGRREAVKLLRRCLADRRGItSENEREVRQLssetdLE 173
Cdd:COG0790  166 AEQGDADAQYNLGVLYENGRGvPKDPAK----ALEWYRKAAEQGDADAQYNLGRLYLNGEGV-EKDLEKALRW-----LR 235


                 ....*.
gi 317373289 174 RAVRKA 179
Cdd:COG0790  236 KAAEQA 241
 
Name Accession Description Interval E-value
WC-rich pfam20053
Wolframin cysteine-rich domain; Located N-terminal to the wolframin OB-fold domain, this ...
 666-769 5.08e-51

Wolframin cysteine-rich domain; Located N-terminal to the wolframin OB-fold domain, this region could represent an extension to the core of the OB fold domain. The observed conserved cysteine residues could contribute to disulfide-bond-mediated cross-linking in calcium-stores regulation.


Pssm-ID: 466275  Cd Length: 106  Bit Score: 174.06  E-value: 5.08e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373289  666 WQQYGALCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTDIDNSAESAINMLPFFIGDWMRCLYGEAYPA-CSP 744
Cdd:pfam20053   1 WEQYQNLCGQPAWEESNKAQTQIRCSHLEGHKVNWEGYVKNVRIKSIENSAESVLNYLPVFLADWLRCLYGEPYPEdCDK 80

                          90       100
                  ....*....|....*....|....*.
gi 317373289  745 GNTSTAEE-ELCRLKLLAKHPCHIKK 769
Cdd:pfam20053  81 FLLSVQEEeELCRLKKLAKNKCHLKR 106
WCOB pfam19913
Wolframin C-terminal OB-fold domain; OB fold domain found at the C-terminus of the wolframin ...
 770-876 1.13e-29

Wolframin C-terminal OB-fold domain; OB fold domain found at the C-terminus of the wolframin protein. Localizes to the ER lumen and lacks the conserved polar residues typical of OB-fold domain-mediated nucleic acid-binding. Predicted to mediate protein-protein interactions.


Pssm-ID: 437745  Cd Length: 120  Bit Score: 113.94  E-value: 1.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373289  770 FDRYKFEITVGMPFSSGadgsrsreeDDVTKDIVLRASSEFKSVLLSLRQGSLIEFSTILEG-RLGSKWPVFELKAISCL 848
Cdd:pfam19913   1 WNRYTFEVTVKMPSGGW---------LDRTADIILKADHEFKNFTLSLRPGDKVRFSGTLEGyRLGSKDPQLELKEIECL 71

                          90       100
                  ....*....|....*....|....*...
gi 317373289  849 NCMAQLSPTRRHVKIEHDWRSTVHGAVK 876
Cdd:pfam19913  72 DCKSSLLTASRKRKIERDWRGTLKDILR 99
WEF-hand pfam19914
Wolframin EF-hand domain; Contains two characteriztic copies of the bihelical repeat forming ...
 176-255 2.50e-28

Wolframin EF-hand domain; Contains two characteriztic copies of the bihelical repeat forming the basic EF-hand unit. The absence of the characteriztic calcium-binding motif, suggesting it could self-dimerize or dimerize with other EF-hand-containing proteins.


Pssm-ID: 466231  Cd Length: 80  Bit Score: 108.82  E-value: 2.50e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373289  176 VRKAALVMYWKLNpKKKKQVAVAELLENVGQVNEHDGGAQPGPVPKSL-QKQRRMLERLVSSESKNYIALDDFVEITKKY 254
Cdd:pfam19914   1 ARKAAREMFASLS-NGKEFITVSQLLRNMREINATDGGSRREPGPGSTsNKSRKVLESLVSSESDRFITEDDLVSAAKKY 79


                  .
gi 317373289  255 A 255
Cdd:pfam19914  80 A 80
WSLR pfam20023
Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This ...
 137-175 3.58e-10

Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This region has been linked to calmodulin-binding, suggesting these repeats may mediate a protein interaction.


Pssm-ID: 466262  Cd Length: 39  Bit Score: 55.63  E-value: 3.58e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 317373289  137 GRREAVKLLRRCLADRRGITSENEREVRQLSSETDLERA 175
Cdd:pfam20023   1 GHEAATELLKHCLETGKGITEENEEEVNSCLAVSWLEKA 39
WSLR pfam20023
Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This ...
 99-133 1.17e-07

Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This region has been linked to calmodulin-binding, suggesting these repeats may mediate a protein interaction.


Pssm-ID: 466262  Cd Length: 39  Bit Score: 48.70  E-value: 1.17e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 317373289   99 DPKAQTEVGKHYLQ----LAGDTDEELNSCTAVDWLVLA 133
Cdd:pfam20023   1 GHEAATELLKHCLEtgkgITEENEEEVNSCLAVSWLEKA 39
TPR COG0790
TPR repeat [General function prediction only];
95-179 1.39e-04

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 44.53  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373289  95 AKAGDPKAQTEVGKHYLQLAG-DTDEELnsctAVDWLVLAAKQGRREAVKLLRRCLADRRGItSENEREVRQLssetdLE 173
Cdd:COG0790  166 AEQGDADAQYNLGVLYENGRGvPKDPAK----ALEWYRKAAEQGDADAQYNLGRLYLNGEGV-EKDLEKALRW-----LR 235


                 ....*.
gi 317373289 174 RAVRKA 179
Cdd:COG0790  236 KAAEQA 241
TPR COG0790
TPR repeat [General function prediction only];
95-180 3.66e-04

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 42.99  E-value: 3.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373289  95 AKAGDPKAQTEVGKHYLQ-LAGDTDEElnscTAVDWLVLAAKQGRREAVKLLRRCLADRRGItsenerevrqlssETDLE 173
Cdd:COG0790  130 AEQGDADAQYNLGLLYLNgEGVPKDPA----KAAEWYRKAAEQGDADAQYNLGVLYENGRGV-------------PKDPA 192

                         90
                 ....*....|
gi 317373289 174 RAV---RKAA 180
Cdd:COG0790  193 KALewyRKAA 202
TPR COG0790
TPR repeat [General function prediction only];
73-180 1.18e-03

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 41.45  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373289  73 RADGTGPTKGDMEIPFEEVLERAKAGDPKAQTEVGKHYLQLAG-DTDEELnsctAVDWLVLAAKQGRREAVKLLRRCLAD 151
Cdd:COG0790   36 AAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGvPKDYEK----ALEWFEKAAEQGDAEAQYNLGLMYEE 111

                         90       100       110
                 ....*....|....*....|....*....|..
gi 317373289 152 RRGItsenerevrqlssETDLERAV---RKAA 180
Cdd:COG0790  112 GLGV-------------PQDYAKALewyEKAA 130
TPR COG0790
TPR repeat [General function prediction only];
74-180 1.50e-03

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 41.07  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373289  74 ADGTGPTKgDMEIPFEEVLERAKAGDPKAQTEVGKHYLQ-LAGDTDEELnsctAVDWLVLAAKQGRREAVKLLRRCLADR 152
Cdd:COG0790   74 AEGRGVPK-DYEKALEWFEKAAEQGDAEAQYNLGLMYEEgLGVPQDYAK----ALEWYEKAAEQGDADAQYNLGLLYLNG 148

                         90       100       110
                 ....*....|....*....|....*....|.
gi 317373289 153 RGItsenerevrqlssETDLERAV---RKAA 180
Cdd:COG0790  149 EGV-------------PKDPAKAAewyRKAA 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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