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Conserved domains on  [gi|47605369|sp|O46634|]
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RecName: Full=CD166 antigen; AltName: Full=Activated leukocyte cell adhesion molecule; AltName: Full=SB-10 antigen; AltName: CD_antigen=CD166

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 75-169 1.33e-20

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


:

Pssm-ID: 400489  Cd Length: 89  Bit Score: 86.32  E-value: 1.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605369    75 PEIVSKAPFLETEQLKKLGDCISKDSYPDGNITWYRNGkvlQPLEGVVVlifKKQMDPVTQLYTMTSSLEYKATKADIQM 154
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDG---KPLEAAET---SSEQDPESGLVTVTSELKLVPSRSDHGQ 74

                          90
                  ....*....|....*
gi 47605369   155 QFTCSVTYYGPSGQK 169
Cdd:pfam08205  75 SLTCQVSYGALRGSI 89
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 188-251 6.36e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 44.09  E-value: 6.36e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47605369   188 TIQVLPSKTAIKEGDIITLKCLGNGNPPPeEFLFYLPGQPEG---------IRSSNTYTLTDVRRNATGDYKC 251
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPP-TITWYKNGEPISsgstrsrslSGSNSTLTISNVTRSDAGTYTC 74
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 370-435 1.47e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


:

Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 43.09  E-value: 1.47e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47605369 370 TIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSTIIN-SPEENVTLTCTAENQLERTVNS 435
Cdd:cd00096   2 TLTCSASGNPPPTITWYKNGKPLPPSSRDSRRSELGNGTLTISNvTLEDSGTYTCVASNSAGGSASA 68
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 277-331 1.60e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.57  E-value: 1.60e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47605369    277 SGEVTKQIGDALPVSCTISASRNATVVWMK---------DNIRLRSSPS-----FSSLQYQDAGNYVCE 331
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKqggkllaesGRFSVSRSGStstltISNVTPEDSGTYTCA 69
 
Name Accession Description Interval E-value
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 75-169 1.33e-20

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 86.32  E-value: 1.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605369    75 PEIVSKAPFLETEQLKKLGDCISKDSYPDGNITWYRNGkvlQPLEGVVVlifKKQMDPVTQLYTMTSSLEYKATKADIQM 154
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDG---KPLEAAET---SSEQDPESGLVTVTSELKLVPSRSDHGQ 74

                          90
                  ....*....|....*
gi 47605369   155 QFTCSVTYYGPSGQK 169
Cdd:pfam08205  75 SLTCQVSYGALRGSI 89
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 74-164 3.08e-07

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 48.61  E-value: 3.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605369  74 KPEIVSKAPFLETEQLKKLGdCISKDSYPDG-NITWYRNGKVLQplEGVVVLIFKKQMDpvtQLYTMTSSLEYKATKADI 152
Cdd:cd00098   1 TVTLLPPSPEEKGGGKVTLV-CLVSGFYPKDiTVTWLKNGVPLT--SGVSTSSPVEPND---GTYSVTSSLTVPPSDWDE 74

                        90
                ....*....|..
gi 47605369 153 QMQFTCSVTYYG 164
Cdd:cd00098  75 GATYTCVVTHES 86
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 188-251 6.36e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 44.09  E-value: 6.36e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47605369   188 TIQVLPSKTAIKEGDIITLKCLGNGNPPPeEFLFYLPGQPEG---------IRSSNTYTLTDVRRNATGDYKC 251
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPP-TITWYKNGEPISsgstrsrslSGSNSTLTISNVTRSDAGTYTC 74
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 370-435 1.47e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 43.09  E-value: 1.47e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47605369 370 TIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSTIIN-SPEENVTLTCTAENQLERTVNS 435
Cdd:cd00096   2 TLTCSASGNPPPTITWYKNGKPLPPSSRDSRRSELGNGTLTISNvTLEDSGTYTCVASNSAGGSASA 68
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 353-427 3.43e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 42.17  E-value: 3.43e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47605369   353 KPQIKMTKK--TDPSGLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSTIIN-SPEENVTLTCTAEN 427
Cdd:pfam13927   1 KPVITVSPSsvTVREGETVTLTCEATGSPPPTITWYKNGEPISSGSTRSRSLSGSNSTLTISNvTRSDAGTYTCVASN 78
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 193-267 4.72e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 4.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605369    193 PSKTAIKEGDIITLKCLGNGNPPPEEFLFYLPGQP-------EGIRSSNTYTLT--DVRRNATGDYKCSLIDKKSMIAST 263
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLlaesgrfSVSRSGSTSTLTisNVTPEDSGTYTCAATNSSGSASSG 80


                   ....*
gi 47605369    264 A-ITV 267
Cdd:smart00410  81 TtLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 277-331 1.60e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.57  E-value: 1.60e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47605369    277 SGEVTKQIGDALPVSCTISASRNATVVWMK---------DNIRLRSSPS-----FSSLQYQDAGNYVCE 331
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKqggkllaesGRFSVSRSGStstltISNVTPEDSGTYTCA 69
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 284-350 1.92e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 37.37  E-value: 1.92e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47605369   284 IGDALPVSCTISASRNATVVWMKDNIRLRSSPSFSSLQY--QDAGNYVCETALQevEGLKKRESLTLIV 350
Cdd:pfam13895  13 EGEPVTLTCSAPGNPPPSYTWYKDGSAISSSPNFFTLSVsaEDSGTYTCVARNG--RGGKVSNPVELTV 79
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 290-331 3.04e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.54  E-value: 3.04e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47605369 290 VSCTISASRNATVVWMKDNIRLRSSP-------------SFSSLQYQDAGNYVCE 331
Cdd:cd00096   3 LTCSASGNPPPTITWYKNGKPLPPSSrdsrrselgngtlTISNVTLEDSGTYTCV 57
 
Name Accession Description Interval E-value
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 75-169 1.33e-20

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 86.32  E-value: 1.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605369    75 PEIVSKAPFLETEQLKKLGDCISKDSYPDGNITWYRNGkvlQPLEGVVVlifKKQMDPVTQLYTMTSSLEYKATKADIQM 154
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDG---KPLEAAET---SSEQDPESGLVTVTSELKLVPSRSDHGQ 74

                          90
                  ....*....|....*
gi 47605369   155 QFTCSVTYYGPSGQK 169
Cdd:pfam08205  75 SLTCQVSYGALRGSI 89
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 74-164 3.08e-07

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 48.61  E-value: 3.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605369  74 KPEIVSKAPFLETEQLKKLGdCISKDSYPDG-NITWYRNGKVLQplEGVVVLIFKKQMDpvtQLYTMTSSLEYKATKADI 152
Cdd:cd00098   1 TVTLLPPSPEEKGGGKVTLV-CLVSGFYPKDiTVTWLKNGVPLT--SGVSTSSPVEPND---GTYSVTSSLTVPPSDWDE 74

                        90
                ....*....|..
gi 47605369 153 QMQFTCSVTYYG 164
Cdd:cd00098  75 GATYTCVVTHES 86
IgI_2_Necl-1 cd07705
Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1); member of the I-set ...
 72-162 6.80e-07

Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1; also known as cell adhesion molecule3 (CADM3)). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains is essential to cell-cell adhesion and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Ig domains are likely to participate in ligand binding and recognition.


Pssm-ID: 409502  Cd Length: 103  Bit Score: 47.66  E-value: 6.80e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605369  72 PSKPEIVSKAPFLETEQLKKLgDCISKDSYPDGNITWYRNGkvlQPLEGVVVLIfkkQMDPVTQLYTMTSSLEYKATKAD 151
Cdd:cd07705   4 PQKPQITGYESAFKEKDKAKL-RCTSSGSKPAANIKWRKGD---QELEGAPTSV---QEDGNGKTFTVSSSVEFQVTRED 76

                        90
                ....*....|.
gi 47605369 152 IQMQFTCSVTY 162
Cdd:cd07705  77 DGAEITCSVGH 87
IgC1_TCR_beta cd05769
T cell receptor (TCR) beta chain constant immunoglobulin domain; member of the C1-set of Ig ...
 62-177 5.67e-06

T cell receptor (TCR) beta chain constant immunoglobulin domain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the T cell receptor (TCR) beta chain constant immunoglobulin domain. TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the beta chain. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The antigen binding site is formed by the variable domains of the alpha and beta chains, located at the N-terminus of each chain. Alpha/beta TCRs recognize antigens differently from gamma/delta TCRs.


Pssm-ID: 409426 [Multi-domain]  Cd Length: 116  Bit Score: 45.45  E-value: 5.67e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605369  62 APTiVKVFKqPSKPEIvskapfleTEQLKKLGDCISKDSYPDG-NITWYRNGKVLQplEGVvvlifkkQMDPVTQ----- 135
Cdd:cd05769   2 PPT-VALFP-PSEAEI--------RNKRKATLVCLATGFYPDHvSLSWKVNGKEVK--DGV-------ATDPQALrents 62

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 47605369 136 LYTMTSSLEYKATK-ADIQMQFTCSVTYYGPSGQKTVQSEQAI 177
Cdd:cd05769  63 TYSLSSRLRVSATEwFNPRNTFTCIVKFYGGTDTDTWTQGIAG 105
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 188-251 6.36e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 44.09  E-value: 6.36e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47605369   188 TIQVLPSKTAIKEGDIITLKCLGNGNPPPeEFLFYLPGQPEG---------IRSSNTYTLTDVRRNATGDYKC 251
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPP-TITWYKNGEPISsgstrsrslSGSNSTLTISNVTRSDAGTYTC 74
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 370-435 1.47e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 43.09  E-value: 1.47e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47605369 370 TIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSTIIN-SPEENVTLTCTAENQLERTVNS 435
Cdd:cd00096   2 TLTCSASGNPPPTITWYKNGKPLPPSSRDSRRSELGNGTLTISNvTLEDSGTYTCVASNSAGGSASA 68
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 353-427 3.43e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 42.17  E-value: 3.43e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47605369   353 KPQIKMTKK--TDPSGLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSTIIN-SPEENVTLTCTAEN 427
Cdd:pfam13927   1 KPVITVSPSsvTVREGETVTLTCEATGSPPPTITWYKNGEPISSGSTRSRSLSGSNSTLTISNvTRSDAGTYTCVASN 78
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 193-267 4.72e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 4.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605369    193 PSKTAIKEGDIITLKCLGNGNPPPEEFLFYLPGQP-------EGIRSSNTYTLT--DVRRNATGDYKCSLIDKKSMIAST 263
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLlaesgrfSVSRSGSTSTLTisNVTPEDSGTYTCAATNSSGSASSG 80


                   ....*
gi 47605369    264 A-ITV 267
Cdd:smart00410  81 TtLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 277-331 1.60e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.57  E-value: 1.60e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47605369    277 SGEVTKQIGDALPVSCTISASRNATVVWMK---------DNIRLRSSPS-----FSSLQYQDAGNYVCE 331
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKqggkllaesGRFSVSRSGStstltISNVTPEDSGTYTCA 69
IgC1_CD80 cd16083
Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) ...
 95-171 2.63e-04

Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin constant (IgC)-like domain of the antigen receptor Cluster of Differentiation (CD) 80. CD80 (also known as glycoprotein B7-1) and CD86 (also known as glycoprotein B7-2) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. CD80 contains two Ig-like domains, an amino-terminal immunoglobulin variable (IgV)-like domain characteristic of adhesion molecules, and a membrane proximal immunoglobulin constant (IgC)-like domain similar to the constant domains of antigen receptors. Members of the Ig family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions.


Pssm-ID: 409505  Cd Length: 91  Bit Score: 40.14  E-value: 2.63e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47605369  95 CISKDSYPDGNITWYRNGKVLQPLEGVVVlifkkqMDPVTQLYTMTSSLEYKATKadiQMQFTCSVTYygpsGQKTV 171
Cdd:cd16083  21 CSTSGGFPEPRLSWLENGEELNAINTTVS------QDPETELYTVSSELDFNVTY---NHSIVCLIKY----GDSRV 84
IgI_2_Necl-1-4 cd05761
Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of ...
 72-160 3.70e-04

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 or CADM3), Necl-2 (also known as CADM1), Necl-3 (also known as CADM2) and Necl-4 (also known as CADM4). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system, where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409418  Cd Length: 102  Bit Score: 39.72  E-value: 3.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605369  72 PSKPEI-VSKAPFLETEQLKKlgDCISKDSYPDGNITWYRNGKVLQPLEGVvvlifkkQMDPVTQLYTMTSSLEYKATKA 150
Cdd:cd05761   4 PEKPVItGFTSPVVEGDEITL--TCTTSGSKPAADIRWFKNDKELKGVKEV-------QESGAGKTFTVTSTLRFRVDRD 74

                        90
                ....*....|
gi 47605369 151 DIQMQFTCSV 160
Cdd:cd05761  75 DDGVAVICRV 84
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 284-350 1.92e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 37.37  E-value: 1.92e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47605369   284 IGDALPVSCTISASRNATVVWMKDNIRLRSSPSFSSLQY--QDAGNYVCETALQevEGLKKRESLTLIV 350
Cdd:pfam13895  13 EGEPVTLTCSAPGNPPPSYTWYKDGSAISSSPNFFTLSVsaEDSGTYTCVARNG--RGGKVSNPVELTV 79
IgI_2_Necl-3 cd05884
Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set ...
 68-160 2.93e-03

Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3; also known as cell adhesion molecule 2 (CADM2)). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Ig domains are likely to participate in ligand binding and recognition.


Pssm-ID: 409467  Cd Length: 104  Bit Score: 37.60  E-value: 2.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605369  68 VFKQPSKPEIVS-KAPFLETEQLKKlgDCISKDSYPDGNITWYRNGKVLQPLEGVvvlifkKQMDPVTQLYTMTSSLEYK 146
Cdd:cd05884   1 VLGVPEKPQISGfTSPVMEGDHIQL--TCKTSGSKPAADIRWFKNDKEVKDVKYL------KAEDANRKTFTVSSSLDFH 72

                        90
                ....*....|....
gi 47605369 147 ATKADIQMQFTCSV 160
Cdd:cd05884  73 VDRDDDGVAITCRV 86
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 290-331 3.04e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.54  E-value: 3.04e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47605369 290 VSCTISASRNATVVWMKDNIRLRSSP-------------SFSSLQYQDAGNYVCE 331
Cdd:cd00096   3 LTCSASGNPPPTITWYKNGKPLPPSSrdsrrselgngtlTISNVTLEDSGTYTCV 57
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 276-331 5.05e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.00  E-value: 5.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47605369   276 PSGEVTKQIGDALPVSCTISASRNATVVWMKDNIRLRSSPS-------------FSSLQYQDAGNYVCE 331
Cdd:pfam13927   7 SPSSVTVREGETVTLTCEATGSPPPTITWYKNGEPISSGSTrsrslsgsnstltISNVTRSDAGTYTCV 75
IgC1_SIRP_domain_2 cd05772
Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig ...
 72-160 6.08e-03

Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig)-like domain in Signal-Regulatory Protein (SIRP), domain 2 (C1 repeat 1). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three Immunoglobulin superfamily domains, a single V-set and two C1-set IgSF domains. Their cytoplasmic tails contain either ITIMs or transmembrane regions that have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47, but with much less affinity.


Pssm-ID: 409429  Cd Length: 102  Bit Score: 36.53  E-value: 6.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605369  72 PSKPEIVSKAPFLETEQLKKLgDCISKDSYP-DGNITWYRNGKVLQPLEGVVVLIFKKQMdpvtqlYTMTSSLEYKATKA 150
Cdd:cd05772   2 PSQPLVSGPSGRATPGQTVSF-TCKSHGFSPrDITLKWFKNGNELSALQTTVFPEGDSVS------YSVSSTVQVVLTKD 74

                        90
                ....*....|
gi 47605369 151 DIQMQFTCSV 160
Cdd:cd05772  75 DVHSQLTCEV 84
IgI_2_Follistatin_like cd05736
Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; ...
 354-438 7.96e-03

Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain found in human Follistatin-related protein 5 (FSTL5) and a follistatin-like molecule encoded by the CNS-related Mahya gene. Mahya genes have been retained in certain Bilaterian branches during evolution. They are conserved in Hymenoptera and Deuterostomes, but are absent from other metazoan species such as fruit fly and nematode. Mahya proteins are secretory, with a follistatin-like domain (Kazal-type serine/threonine protease inhibitor domain and EF-hand calcium-binding domain), two Ig-like domains, and a novel C-terminal domain. Mahya may be involved in learning and memory and in processing of sensory information in Hymenoptera and vertebrates. Follistatin is a secreted, multidomain protein that binds activins with high affinity and antagonizes their signaling.


Pssm-ID: 409399 [Multi-domain]  Cd Length: 93  Bit Score: 36.09  E-value: 7.96e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605369 354 PQIKMTKKTDPS--GLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYI-NGRyySTIINSP--EENVTLTCTAENQ 428
Cdd:cd05736   1 PVIRVYPEFQAKepGVEASLRCHAEGIPLPRVQWLKNGMDINPKLSKQLTLIaNGS--ELHISNVryEDTGAYTCIAKNE 78

                        90
                ....*....|..
gi 47605369 429 --LERTVNSLNV 438
Cdd:cd05736  79 ggVDEDISSLFV 90
C1-set pfam07654
Immunoglobulin C1-set domain;
95-164 9.33e-03

Immunoglobulin C1-set domain;


Pssm-ID: 462221  Cd Length: 85  Bit Score: 35.30  E-value: 9.33e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47605369    95 CISKDSYP-DGNITWYRNGKVLQplEGVVVLIFKKQMDpvtQLYTMTSSLEYKATKADIQMQFTCSVTYYG 164
Cdd:pfam07654  19 CLVTGFYPpDITVTWLKNGQEVT--EGVKTTPPSPNSD---WTYQLSSYLTVTPSDWESGDEYTCRVEHEG 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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