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Conserved domains on  [gi|47550919|ref|NP_999633|]
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77 kDa echinoderm microtubule-associated protein [Strongylocentrotus purpuratus]

Protein Classification

HELP and WD40 domain-containing protein( domain architecture ID 13687810)

HELP and WD40 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 62-132 6.03e-37

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 132.29  E-value: 6.03e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47550919    62 RIYLRGRPVTNYLPSD-VEDYDLNAKHPAPTEKLKLDWVYGYRGRDCRCNLYLLPTGEIIYFMAAVVVLYNV 132
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNyYPKDDLDQKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 COG2319
WD40 repeat [General function prediction only];
141-574 1.51e-30

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.25  E-value: 1.51e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 141 TGHNDDVKSIAVHPDSVTIATGQVAGHdpdegkphVRIWNSITMETLHVLGLGFFDRAVCALSFSkvnvGVHLAAVdeSN 220
Cdd:COG2319  33 LGLAAAVASLAASPDGARLAAGAGDLT--------LLLLDAAAGALLATLLGHTAAVLSVAFSPD----GRLLASA--SA 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 221 EHVLSVWDWKKEKKLSDTKSSQDPVLACEYHPmNDEQIITLGKGH-IHFWNTTGGKLVKksgIFEKYDKPkfVLSLAFTG 299
Cdd:COG2319  99 DGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGtVRLWDLATGKLLR---TLTGHSGA--VTSVAFSP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 300 NGDVI-TGDSNGNMYIWGKGNTRISQAILGaHEGGIFSLCVMNDGQILSGGGKDKKVILWTADyqqsevtqvteaTG-PV 377
Cdd:COG2319 173 DGKLLaSGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLA------------TGkLL 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 378 RTLckgkgedfyvgttrnailsgnmggefntlvQAHTEELWGLALHPTQGLFLTCGYDKNVIMWDFEQHKPMWNKLMEDG 457
Cdd:COG2319 240 RTL------------------------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 458 C-QSAGFHPSGAVVAIGMTSGRWVALDVESQDLITVHTDGKEQHDIIRYSPDGNFLAVASHDNYIYIYSVTEEGRkyskV 536
Cdd:COG2319 290 GvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL----L 365

                       410       420       430
                ....*....|....*....|....*....|....*...
gi 47550919 537 GKCSGHSSFVTHIDWSADSTKLQSNSGDYELLFWDAAT 574
Cdd:COG2319 366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 pfam00400
WD domain, G-beta repeat;
649-684 1.11e-03

WD domain, G-beta repeat;


:

Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 47550919   649 TSFKGHSSHVTSVAFNGDStKLISTGGRDMSCMQWS 684
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 62-132 6.03e-37

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 132.29  E-value: 6.03e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47550919    62 RIYLRGRPVTNYLPSD-VEDYDLNAKHPAPTEKLKLDWVYGYRGRDCRCNLYLLPTGEIIYFMAAVVVLYNV 132
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNyYPKDDLDQKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 COG2319
WD40 repeat [General function prediction only];
141-574 1.51e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.25  E-value: 1.51e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 141 TGHNDDVKSIAVHPDSVTIATGQVAGHdpdegkphVRIWNSITMETLHVLGLGFFDRAVCALSFSkvnvGVHLAAVdeSN 220
Cdd:COG2319  33 LGLAAAVASLAASPDGARLAAGAGDLT--------LLLLDAAAGALLATLLGHTAAVLSVAFSPD----GRLLASA--SA 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 221 EHVLSVWDWKKEKKLSDTKSSQDPVLACEYHPmNDEQIITLGKGH-IHFWNTTGGKLVKksgIFEKYDKPkfVLSLAFTG 299
Cdd:COG2319  99 DGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGtVRLWDLATGKLLR---TLTGHSGA--VTSVAFSP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 300 NGDVI-TGDSNGNMYIWGKGNTRISQAILGaHEGGIFSLCVMNDGQILSGGGKDKKVILWTADyqqsevtqvteaTG-PV 377
Cdd:COG2319 173 DGKLLaSGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLA------------TGkLL 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 378 RTLckgkgedfyvgttrnailsgnmggefntlvQAHTEELWGLALHPTQGLFLTCGYDKNVIMWDFEQHKPMWNKLMEDG 457
Cdd:COG2319 240 RTL------------------------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 458 C-QSAGFHPSGAVVAIGMTSGRWVALDVESQDLITVHTDGKEQHDIIRYSPDGNFLAVASHDNYIYIYSVTEEGRkyskV 536
Cdd:COG2319 290 GvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL----L 365

                       410       420       430
                ....*....|....*....|....*....|....*...
gi 47550919 537 GKCSGHSSFVTHIDWSADSTKLQSNSGDYELLFWDAAT 574
Cdd:COG2319 366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 330-684 6.19e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 6.19e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 330 HEGGIFSLCVMNDGQILSGGGKDKKVILWTADYQQSEVTQvTEATGPVRTL---CKGK-----GEDfyvGTTRnaILSGN 401
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVaasADGTylasgSSD---KTIR--LWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 402 MGGEFNTLVQaHTEELWGLALHPTQGLFLTCGYDKNVIMWDFEQHKPmwnklmedgCQSAGFHpSGAVVAIgmtsgrwva 481
Cdd:cd00200  82 TGECVRTLTG-HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC---------LTTLRGH-TDWVNSV--------- 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 482 ldvesqdlitvhtdgkeqhdiiRYSPDGNFLAVASHDNYIYIYSVTEEgrkySKVGKCSGHSSFVTHIDWSADSTKLQSN 561
Cdd:cd00200 142 ----------------------AFSPDGTFVASSSQDGTIKLWDLRTG----KCVATLTGHTGEVNSVAFSPDGEKLLSS 195

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 562 SGDYELLFWDAATCKQIvisketrdvewATFTGVLGYpvcgiwpegsdgtdVNTTARSANGNLLASGDDFGKINLFRYpv 641
Cdd:cd00200 196 SSDGTIKLWDLSTGKCL-----------GTLRGHENG--------------VNSVAFSPDGYLLASGSEDGTIRVWDL-- 248

                       330       340       350       360
                ....*....|....*....|....*....|....*....|...
gi 47550919 642 nHPKADCTSFKGHSSHVTSVAFNGDSTKLISTGGrDMSCMQWS 684
Cdd:cd00200 249 -RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA-DGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 411-442 9.14e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 9.14e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 47550919    411 QAHTEELWGLALHPTQGLFLTCGYDKNVIMWD 442
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
649-684 1.11e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 47550919   649 TSFKGHSSHVTSVAFNGDStKLISTGGRDMSCMQWS 684
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 650-684 1.37e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.37e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 47550919    650 SFKGHSSHVTSVAFNGDSTKLIStGGRDMSCMQWS 684
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLAS-GSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
404-442 5.25e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 5.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47550919   404 GEFNTLVQAHTEELWGLALHPTQGLFLTCGYDKNVIMWD 442
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 62-132 6.03e-37

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 132.29  E-value: 6.03e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47550919    62 RIYLRGRPVTNYLPSD-VEDYDLNAKHPAPTEKLKLDWVYGYRGRDCRCNLYLLPTGEIIYFMAAVVVLYNV 132
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNyYPKDDLDQKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 COG2319
WD40 repeat [General function prediction only];
141-574 1.51e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.25  E-value: 1.51e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 141 TGHNDDVKSIAVHPDSVTIATGQVAGHdpdegkphVRIWNSITMETLHVLGLGFFDRAVCALSFSkvnvGVHLAAVdeSN 220
Cdd:COG2319  33 LGLAAAVASLAASPDGARLAAGAGDLT--------LLLLDAAAGALLATLLGHTAAVLSVAFSPD----GRLLASA--SA 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 221 EHVLSVWDWKKEKKLSDTKSSQDPVLACEYHPmNDEQIITLGKGH-IHFWNTTGGKLVKksgIFEKYDKPkfVLSLAFTG 299
Cdd:COG2319  99 DGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGtVRLWDLATGKLLR---TLTGHSGA--VTSVAFSP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 300 NGDVI-TGDSNGNMYIWGKGNTRISQAILGaHEGGIFSLCVMNDGQILSGGGKDKKVILWTADyqqsevtqvteaTG-PV 377
Cdd:COG2319 173 DGKLLaSGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLA------------TGkLL 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 378 RTLckgkgedfyvgttrnailsgnmggefntlvQAHTEELWGLALHPTQGLFLTCGYDKNVIMWDFEQHKPMWNKLMEDG 457
Cdd:COG2319 240 RTL------------------------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 458 C-QSAGFHPSGAVVAIGMTSGRWVALDVESQDLITVHTDGKEQHDIIRYSPDGNFLAVASHDNYIYIYSVTEEGRkyskV 536
Cdd:COG2319 290 GvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL----L 365

                       410       420       430
                ....*....|....*....|....*....|....*...
gi 47550919 537 GKCSGHSSFVTHIDWSADSTKLQSNSGDYELLFWDAAT 574
Cdd:COG2319 366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 330-684 6.19e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 6.19e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 330 HEGGIFSLCVMNDGQILSGGGKDKKVILWTADYQQSEVTQvTEATGPVRTL---CKGK-----GEDfyvGTTRnaILSGN 401
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVaasADGTylasgSSD---KTIR--LWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 402 MGGEFNTLVQaHTEELWGLALHPTQGLFLTCGYDKNVIMWDFEQHKPmwnklmedgCQSAGFHpSGAVVAIgmtsgrwva 481
Cdd:cd00200  82 TGECVRTLTG-HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC---------LTTLRGH-TDWVNSV--------- 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 482 ldvesqdlitvhtdgkeqhdiiRYSPDGNFLAVASHDNYIYIYSVTEEgrkySKVGKCSGHSSFVTHIDWSADSTKLQSN 561
Cdd:cd00200 142 ----------------------AFSPDGTFVASSSQDGTIKLWDLRTG----KCVATLTGHTGEVNSVAFSPDGEKLLSS 195

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 562 SGDYELLFWDAATCKQIvisketrdvewATFTGVLGYpvcgiwpegsdgtdVNTTARSANGNLLASGDDFGKINLFRYpv 641
Cdd:cd00200 196 SSDGTIKLWDLSTGKCL-----------GTLRGHENG--------------VNSVAFSPDGYLLASGSEDGTIRVWDL-- 248

                       330       340       350       360
                ....*....|....*....|....*....|....*....|...
gi 47550919 642 nHPKADCTSFKGHSSHVTSVAFNGDSTKLISTGGrDMSCMQWS 684
Cdd:cd00200 249 -RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA-DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
214-677 1.38e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 1.38e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 214 AAVDESNEHVLSVWDWKKEKKLSDTKSSQDPVLACEYHPMNDEQIITLGKGHIHFWNTTGGKLVKKSGIFEKydkpkFVL 293
Cdd:COG2319   8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA-----AVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 294 SLAFTGNGDVI-TGDSNGNMYIWgKGNTRISQAILGAHEGGIFSLCVMNDGQILSGGGKDKKVILWTAdyqqsevtqvte 372
Cdd:COG2319  83 SVAFSPDGRLLaSASADGTVRLW-DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL------------ 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 373 ATG-PVRTLckgkgedfyvgttrnailsgnmggefntlvQAHTEELWGLALHPTQGLFLTCGYDKNVIMWDFEQHKPMWN 451
Cdd:COG2319 150 ATGkLLRTL------------------------------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 452 -KLMEDGCQSAGFHPSGAVVAIGMTSGRWVALDVESQDLITVHTDGKEQHDIIRYSPDGNFLAVASHDNYIYIYSVtEEG 530
Cdd:COG2319 200 lTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATG 278

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 531 RKyskVGKCSGHSSFVTHIDWSADSTKLQSNSGDYELLFWDAATCKQIvisketrdvewATFTGvlgypvcgiwpegsDG 610
Cdd:COG2319 279 EL---LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL-----------RTLTG--------------HT 330

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47550919 611 TDVNTTARSANGNLLASGDDFGKINLFRypVNHPKADCTsFKGHSSHVTSVAFNGDSTKLIStGGRD 677
Cdd:COG2319 331 GAVRSVAFSPDGKTLASGSDDGTVRLWD--LATGELLRT-LTGHTGAVTSVAFSPDGRTLAS-GSAD 393
WD40 COG2319
WD40 repeat [General function prediction only];
213-638 7.59e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 7.59e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 213 LAAVDESNEHVLSVWDWKKEKKLSDTKSSQDPVLACEYHPMNDEQIITLGKGHIHFWNTTGGKLVKKSGIFEKYdkpkfV 292
Cdd:COG2319  49 ARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGA-----V 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 293 LSLAFTGNGD-VITGDSNGNMYIWGKGNTRISQAILGaHEGGIFSLCVMNDGQILSGGGKDKKVILWTAdyqqsevtqvt 371
Cdd:COG2319 124 RSVAFSPDGKtLASGSADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDL----------- 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 372 eATG-PVRTLckgkgedfyvgttrnailsgnmggefntlvQAHTEELWGLALHPTQGLFLTCGYDKNVIMWDFEQHKPMW 450
Cdd:COG2319 192 -ATGkLLRTL------------------------------TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 451 N-KLMEDGCQSAGFHPSGAVVAIGMTSGRWVALDVESQDLITVHTDGKEQHDIIRYSPDGNFLAVASHDNYIYIYSVtEE 529
Cdd:COG2319 241 TlTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL-AT 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 530 GRKyskVGKCSGHSSFVTHIDWSADSTKLQSNSGDYELLFWDAATCKQIvisketrdvewATFTGVLGYpvcgiwpegsd 609
Cdd:COG2319 320 GKL---LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL-----------RTLTGHTGA----------- 374

                       410       420
                ....*....|....*....|....*....
gi 47550919 610 gtdVNTTARSANGNLLASGDDFGKINLFR 638
Cdd:COG2319 375 ---VTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 138-442 7.50e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 7.50e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 138 RHYTGHNDDVKSIAVHPDSVTIATGqvaGHDpdeGKphVRIWNSITMETLHVL-GLGFFDRAVCALSFSKVnvgvhLAAV 216
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATG---SGD---GT--IKVWDLETGELLRTLkGHTGPVRDVAASADGTY-----LASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 217 deSNEHVLSVWDWKKEKKLSDTKSSQDPVLACEYHPmnDEQIITLGKGH--IHFWNTTGGKLVkksgiFEKYDKPKFVLS 294
Cdd:cd00200  70 --SSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP--DGRILSSSSRDktIKVWDVETGKCL-----TTLRGHTDWVNS 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 295 LAFTGNGDVIT-GDSNGNMYIWgKGNTRISQAILGAHEGGIFSLCVMNDGQILSGGGKDKKVILWTADyQQSEVTQVTEA 373
Cdd:cd00200 141 VAFSPDGTFVAsSSQDGTIKLW-DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS-TGKCLGTLRGH 218

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47550919 374 TGPVRTLCKGKGEDFYVGTTRNAIL---SGNMGGEFNTLvQAHTEELWGLALHPTQGLFLTCGYDKNVIMWD 442
Cdd:cd00200 219 ENGVNSVAFSPDGYLLASGSEDGTIrvwDLRTGECVQTL-SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 239-571 1.29e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 1.29e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 239 KSSQDPVLACEYHPmNDEQIITLGK-GHIHFWNTTGGKLvkksgIFEKYDKPKFVLSLAFTGNGD-VITGDSNGNMYIWg 316
Cdd:cd00200   6 KGHTGGVTCVAFSP-DGKLLATGSGdGTIKVWDLETGEL-----LRTLKGHTGPVRDVAASADGTyLASGSSDKTIRLW- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 317 KGNTRISQAILGAHEGGIFSLCVMNDGQILSGGGKDKKVILWTadyqqsevtqvteatgpVRTlckgkgedfyvgttrna 396
Cdd:cd00200  79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD-----------------VET----------------- 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 397 ilsgnmgGEFNTLVQAHTEELWGLALHPTQGLFLTCGYDKNVIMWDFEQHKPMWN-KLMEDGCQSAGFHPSGAVVAIG-- 473
Cdd:cd00200 125 -------GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSss 197

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 474 -MTSGRWVALDVESQDLITVHTDGkeqhdI--IRYSPDGNFLAVASHDNYIYIYSVteegRKYSKVGKCSGHSSFVTHID 550
Cdd:cd00200 198 dGTIKLWDLSTGKCLGTLRGHENG-----VnsVAFSPDGYLLASGSEDGTIRVWDL----RTGECVQTLSGHTNSVTSLA 268

                       330       340
                ....*....|....*....|.
gi 47550919 551 WSADSTKLQSNSGDYELLFWD 571
Cdd:cd00200 269 WSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
391-685 2.60e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.90  E-value: 2.60e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 391 GTTRNAILSGNMGGEFNTLVQAHTEELWGLALHPTQGLFLTCGYDKNVIMWDFEQHKPMWNKLM-EDGCQSAGFHPSGAV 469
Cdd:COG2319  55 AGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGhTGAVRSVAFSPDGKT 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 470 VAIGmTSGRWVAL-DVESQDLITV---HTDGKEQhdiIRYSPDGNFLAVASHDNYIYIYSVTEegrkyskvGKC----SG 541
Cdd:COG2319 135 LASG-SADGTVRLwDLATGKLLRTltgHSGAVTS---VAFSPDGKLLASGSDDGTVRLWDLAT--------GKLlrtlTG 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 542 HSSFVTHIDWSADSTKLQSNSGDYELLFWDAATCKQIvisketrdvewATFTGvlgypvcgiwpegsDGTDVNTTARSAN 621
Cdd:COG2319 203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL-----------RTLTG--------------HSGSVRSVAFSPD 257

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47550919 622 GNLLASGDDFGKINLFRypVNHPKADcTSFKGHSSHVTSVAFNGDSTKLIStGGRDMSCMQWSV 685
Cdd:COG2319 258 GRLLASGSADGTVRLWD--LATGELL-RTLTGHSGGVNSVAFSPDGKLLAS-GSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 127-358 3.91e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 3.91e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 127 VVLYNVEEQNQRH-YTGHNDDVKSIAVHPDSVTIATGqvaghdPDEGKphVRIWNSITMETLHVLglgffdravcalsfs 205
Cdd:cd00200 117 IKVWDVETGKCLTtLRGHTDWVNSVAFSPDGTFVASS------SQDGT--IKLWDLRTGKCVATL--------------- 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550919 206 kvnvgvhlaavdesnehvlsvwdwkkekklsdtKSSQDPVLACEYHPMNDEQIITLGKGHIHFWNTTGGKLVKksgIFEK 285
Cdd:cd00200 174 ---------------------------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG---TLRG 217

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47550919 286 ydKPKFVLSLAFTGNGDVIT-GDSNGNMYIWGKGNTRISQaILGAHEGGIFSLCVMNDGQILSGGGKDKKVILW 358
Cdd:cd00200 218 --HENGVNSVAFSPDGYLLAsGSEDGTIRVWDLRTGECVQ-TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 411-442 9.14e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 9.14e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 47550919    411 QAHTEELWGLALHPTQGLFLTCGYDKNVIMWD 442
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
649-684 1.11e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 47550919   649 TSFKGHSSHVTSVAFNGDStKLISTGGRDMSCMQWS 684
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 650-684 1.37e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.37e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 47550919    650 SFKGHSSHVTSVAFNGDSTKLIStGGRDMSCMQWS 684
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLAS-GSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 325-358 4.51e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 4.51e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 47550919    325 AILGAHEGGIFSLCVMNDGQILSGGGKDKKVILW 358
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
404-442 5.25e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 5.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47550919   404 GEFNTLVQAHTEELWGLALHPTQGLFLTCGYDKNVIMWD 442
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 534-571 6.82e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 6.82e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47550919    534 SKVGKCSGHSSFVTHIDWSADSTKLQSNSGDYELLFWD 571
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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