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Conserved domains on  [gi|38201625|ref|NP_937885|]
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eukaryotic translation initiation factor 4 gamma 1 isoform 3 [Homo sapiens]

Protein Classification

eukaryotic translation initiation factor 4 gamma( domain architecture ID 10501430)

eukaryotic translation initiation factor 4 gamma (EIF4G) plays a key functional role in the initiation of cap-dependent translation by acting as an adapter to nucleate the assembly of eIF4F complex

CATH:  1.25.40.180
Gene Ontology:  GO:0003743|GO:0031369|GO:0003723|GO:0003729|GO:0060090|GO:0006446
PubMed:  27694156|9019810|12867079|10872469
SCOP:  4000569

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 597-822 4.56e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 4.56e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    597 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 676
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    677 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 756
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38201625    757 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 822
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1274-1406 7.05e-57

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


:

Pssm-ID: 211397  Cd Length: 134  Bit Score: 192.88  E-value: 7.05e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625 1274 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1352
Cdd:cd11559    1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 38201625 1353 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1406
Cdd:cd11559   81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1078-1190 1.38e-36

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


:

Pssm-ID: 397128  Cd Length: 113  Bit Score: 133.94  E-value: 1.38e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   1078 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1157
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 38201625   1158 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1190
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 177-408 3.07e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   177 SSSPLQAPTPLAshtveIHEPNGMVPSEDLEPEVESSPELAPPPACPSeSPVPIAPTAQ-----PEELLNGAPSPPAVDL 251
Cdd:PHA03247 2676 ASSPPQRPRRRA-----ARPTVGSLTSLADPPPPPPTPEPAPHALVSA-TPLPPGPAAArqaspALPAAPAPPAVPAGPA 2749

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   252 SPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPI---- 327
Cdd:PHA03247 2750 TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplp 2829

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   328 -PANLSQNLEAAAATQVAVSVP-----------KRRRKIKELNKKEAVGDLLDAFKEANPAV---PEVENQPPAGSNPGP 392
Cdd:PHA03247 2830 pPTSAQPTAPPPPPGPPPPSLPlggsvapggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVsrsTESFALPPDQPERPP 2909

                         250
                  ....*....|....*.
gi 38201625   393 ESEgSGVPPRPEEADE 408
Cdd:PHA03247 2910 QPQ-APPPPQPQPQPP 2924
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 36-288 1.50e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 1.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    36 ARTASTPTPPQTGGGLEPQANGETPQVAvIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVlePGSEPN 115
Cdd:PHA03247 2755 ARPARPPTTAGPPAPAPPAAPAAGPPRR-LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA--GPLPPP 2831

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   116 LAVL-------SIPGDTMTTIQMSVEESTPISREtgePYRLSPEPTPLAEPILEVEvTLSKPVPESEFSSSPLQAPTPLA 188
Cdd:PHA03247 2832 TSAQptappppPGPPPPSLPLGGSVAPGGDVRRR---PPSRSPAAKPAAPARPPVR-RLARPAVSRSTESFALPPDQPER 2907

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   189 SHTVEIHEPngmvPSEDLEPEVESSPELAPPPacPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASM 268
Cdd:PHA03247 2908 PPQPQAPPP----PQPQPQPPPPPQPQPPPPP--PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ 2981

                         250       260
                  ....*....|....*....|
gi 38201625   269 APPTIPSATPATAPSATSPA 288
Cdd:PHA03247 2982 PAPSREAPASSTPPLTGHSL 3001
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 597-822 4.56e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 4.56e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    597 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 676
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    677 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 756
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38201625    757 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 822
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1274-1406 7.05e-57

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 192.88  E-value: 7.05e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625 1274 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1352
Cdd:cd11559    1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 38201625 1353 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1406
Cdd:cd11559   81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 598-825 1.58e-53

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 186.03  E-value: 1.58e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625     598 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 677
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625     678 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 757
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 38201625     758 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRGSN 825
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1078-1190 1.38e-36

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 133.94  E-value: 1.38e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   1078 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1157
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 38201625   1158 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1190
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1078-1190 1.55e-35

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 131.21  E-value: 1.55e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    1078 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1157
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 38201625    1158 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1190
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1345-1428 3.10e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 103.52  E-value: 3.10e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    1345 KLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFKW 1424
Cdd:smart00515    2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTW 79


                    ....
gi 38201625    1425 LREA 1428
Cdd:smart00515   80 LQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 1357-1433 6.70e-23

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 93.75  E-value: 6.70e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38201625   1357 ELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFKWLREAEEESD 1433
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
PHA03247 PHA03247
large tegument protein UL36; Provisional
 177-408 3.07e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   177 SSSPLQAPTPLAshtveIHEPNGMVPSEDLEPEVESSPELAPPPACPSeSPVPIAPTAQ-----PEELLNGAPSPPAVDL 251
Cdd:PHA03247 2676 ASSPPQRPRRRA-----ARPTVGSLTSLADPPPPPPTPEPAPHALVSA-TPLPPGPAAArqaspALPAAPAPPAVPAGPA 2749

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   252 SPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPI---- 327
Cdd:PHA03247 2750 TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplp 2829

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   328 -PANLSQNLEAAAATQVAVSVP-----------KRRRKIKELNKKEAVGDLLDAFKEANPAV---PEVENQPPAGSNPGP 392
Cdd:PHA03247 2830 pPTSAQPTAPPPPPGPPPPSLPlggsvapggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVsrsTESFALPPDQPERPP 2909

                         250
                  ....*....|....*.
gi 38201625   393 ESEgSGVPPRPEEADE 408
Cdd:PHA03247 2910 QPQ-APPPPQPQPQPP 2924
PHA03247 PHA03247
large tegument protein UL36; Provisional
 36-288 1.50e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 1.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    36 ARTASTPTPPQTGGGLEPQANGETPQVAvIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVlePGSEPN 115
Cdd:PHA03247 2755 ARPARPPTTAGPPAPAPPAAPAAGPPRR-LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA--GPLPPP 2831

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   116 LAVL-------SIPGDTMTTIQMSVEESTPISREtgePYRLSPEPTPLAEPILEVEvTLSKPVPESEFSSSPLQAPTPLA 188
Cdd:PHA03247 2832 TSAQptappppPGPPPPSLPLGGSVAPGGDVRRR---PPSRSPAAKPAAPARPPVR-RLARPAVSRSTESFALPPDQPER 2907

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   189 SHTVEIHEPngmvPSEDLEPEVESSPELAPPPacPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASM 268
Cdd:PHA03247 2908 PPQPQAPPP----PQPQPQPPPPPQPQPPPPP--PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ 2981

                         250       260
                  ....*....|....*....|
gi 38201625   269 APPTIPSATPATAPSATSPA 288
Cdd:PHA03247 2982 PAPSREAPASSTPPLTGHSL 3001
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 164-349 4.06e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 48.37  E-value: 4.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    164 EVTLSKpVPESEFSSSPLQ-----APTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEE 238
Cdd:pfam05109  418 KVIFSK-APESTTTSPTLNttgfaAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRD 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    239 llNG----------------APSPPAVDLSP-VSEPEEQAKEVTASMAPPTIPSATPatAPSATSPAQEEEMEEEEEEEE 301
Cdd:pfam05109  497 --NGteskapdmtsptsavtTPTPNATSPTPaVTTPTPNATSPTLGKTSPTSAVTTP--TPNATSPTPAVTTPTPNATIP 572

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 38201625    302 GEAGEAGEAESEKGGEELLPP---ESTPIPANLSQNLEAAAATQVAVSVPK 349
Cdd:pfam05109  573 TLGKTSPTSAVTTPTPNATSPtvgETSPQANTTNHTLGGTSSTPVVTSPPK 623
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
204-286 1.70e-04

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 46.15  E-value: 1.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625  204 EDLEPEVESSPELAPPPACPSESPVPIAPTAQPEEllngAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPS 283
Cdd:COG5373   31 EELEAELAEAAEAASAPAEPEPEAAAAATAAAPEA----APAPVPEAPAAPPAAAEAPAPAAAAPPAEAEPAAAPAAASS 106


                 ...
gi 38201625  284 ATS 286
Cdd:COG5373  107 FEE 109
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 597-822 4.56e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 4.56e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    597 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 676
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    677 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 756
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38201625    757 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 822
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1274-1406 7.05e-57

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 192.88  E-value: 7.05e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625 1274 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1352
Cdd:cd11559    1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 38201625 1353 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1406
Cdd:cd11559   81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 598-825 1.58e-53

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 186.03  E-value: 1.58e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625     598 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 677
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625     678 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 757
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 38201625     758 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRGSN 825
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1078-1190 1.38e-36

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 133.94  E-value: 1.38e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   1078 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1157
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 38201625   1158 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1190
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1078-1190 1.55e-35

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 131.21  E-value: 1.55e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    1078 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1157
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 38201625    1158 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1190
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1345-1428 3.10e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 103.52  E-value: 3.10e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    1345 KLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFKW 1424
Cdd:smart00515    2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTW 79


                    ....
gi 38201625    1425 LREA 1428
Cdd:smart00515   80 LQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 1357-1433 6.70e-23

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 93.75  E-value: 6.70e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38201625   1357 ELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFKWLREAEEESD 1433
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 1275-1400 7.07e-23

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 95.62  E-value: 7.07e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625 1275 PSEELNRQLEKLLKEG-SSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFE----TPLRVDVAVLKARAKLLQK 1349
Cdd:cd11473    2 KNKKLRDSLLKELEEDkSSDVESVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESADsislTQKEQLVLVLKKYGPVLRE 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 38201625 1350 YLCD-EQKELQALYALQALVVT--LEQPPNLLRMFFDALYDEDVVKEDAFYSWE 1400
Cdd:cd11473   82 LLKLiKKDQLYLLLKIEKLCLQlkLSELISLLEKILDLLYDADVLSEEAILSWF 135
W2_eIF2B_epsilon cd11558
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ...
 1344-1433 1.07e-14

C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211396  Cd Length: 169  Bit Score: 73.45  E-value: 1.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625 1344 AKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFK 1423
Cdd:cd11558   80 GPLLENYVKSQDDQVELLLALEEFCLESEEGGPLFAKLLHALYDLDILEEEAILEWWEEPDAGADEEMKKVRELVKKFIE 159

                         90
                 ....*....|
gi 38201625 1424 WLREAEEESD 1433
Cdd:cd11558  160 WLEEAEEESD 169
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 1282-1433 1.25e-08

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 55.70  E-value: 1.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625 1282 QLEKLLKEGSSNQRVFDwIEANLSEQQIVSNTLVRALmtavcysAIIFETPLRVD-VAVLKARAKLLQKYLCDEQKELQA 1360
Cdd:cd11561   10 ELGEFLKKNKDESGLSE-LKEILKEAERLDVVKDKAV-------LVLAEVLFDENiVKEIKKRKALLLKLVTDEKAQKAL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38201625 1361 LYALQALVVtlEQPPNLLRMF---FDALYDEDVVKEDAFYSW---ESSKDPAEQQGKGVaLKSVTAFFKWLREAEEESD 1433
Cdd:cd11561   82 LGGIERFCG--KHSPELLKKVpliLKALYDNDILEEEVILKWyekVSKKYVSKEKSKKV-RKAAEPFVEWLEEAEEEEE 157
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 1271-1431 8.10e-08

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 54.14  E-value: 8.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625 1271 QRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSN--------TLVRALMTAVCYSA---IIFETPLRVdvav 1339
Cdd:cd11560   29 YRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSSlpehevvgLLWTALMDAVEWSKkedQIAEQALRH---- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625 1340 LKARAKLLQKYLCDEQKELQALYALQalVVTLEQPpNLLRMFFD---ALYDEDVVKEDAFYSWesSKDPAEQQGKGVALK 1416
Cdd:cd11560  105 LKKYAPLLAAFCTTARAELALLNKIQ--EYCYENM-KFMKVFQKivkLLYKADVLSEDAILKW--YKKGHSPKGKQVFLK 179

                        170
                 ....*....|....*
gi 38201625 1417 SVTAFFKWLREAEEE 1431
Cdd:cd11560  180 QMEPFVEWLQEAEEE 194
PHA03247 PHA03247
large tegument protein UL36; Provisional
 177-408 3.07e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   177 SSSPLQAPTPLAshtveIHEPNGMVPSEDLEPEVESSPELAPPPACPSeSPVPIAPTAQ-----PEELLNGAPSPPAVDL 251
Cdd:PHA03247 2676 ASSPPQRPRRRA-----ARPTVGSLTSLADPPPPPPTPEPAPHALVSA-TPLPPGPAAArqaspALPAAPAPPAVPAGPA 2749

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   252 SPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPI---- 327
Cdd:PHA03247 2750 TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplp 2829

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   328 -PANLSQNLEAAAATQVAVSVP-----------KRRRKIKELNKKEAVGDLLDAFKEANPAV---PEVENQPPAGSNPGP 392
Cdd:PHA03247 2830 pPTSAQPTAPPPPPGPPPPSLPlggsvapggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVsrsTESFALPPDQPERPP 2909

                         250
                  ....*....|....*.
gi 38201625   393 ESEgSGVPPRPEEADE 408
Cdd:PHA03247 2910 QPQ-APPPPQPQPQPP 2924
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
241-409 7.68e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 50.64  E-value: 7.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   241 NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELL 320
Cdd:PRK12323  369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   321 PPESTPIPANLSQNLEAAAATQ----VAVSVPKRRRKIKElnkKEAVGDLLDAFKEANPAVPEVenqPPAGSNPGPESEG 396
Cdd:PRK12323  449 APAPAPAAAPAAAARPAAAGPRpvaaAAAAAPARAAPAAA---PAPADDDPPPWEELPPEFASP---APAQPDAAPAGWV 522

                         170
                  ....*....|...
gi 38201625   397 SGVPPRPEEADET 409
Cdd:PRK12323  523 AESIPDPATADPD 535
PHA03247 PHA03247
large tegument protein UL36; Provisional
 36-288 1.50e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 1.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    36 ARTASTPTPPQTGGGLEPQANGETPQVAvIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVlePGSEPN 115
Cdd:PHA03247 2755 ARPARPPTTAGPPAPAPPAAPAAGPPRR-LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA--GPLPPP 2831

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   116 LAVL-------SIPGDTMTTIQMSVEESTPISREtgePYRLSPEPTPLAEPILEVEvTLSKPVPESEFSSSPLQAPTPLA 188
Cdd:PHA03247 2832 TSAQptappppPGPPPPSLPLGGSVAPGGDVRRR---PPSRSPAAKPAAPARPPVR-RLARPAVSRSTESFALPPDQPER 2907

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   189 SHTVEIHEPngmvPSEDLEPEVESSPELAPPPacPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASM 268
Cdd:PHA03247 2908 PPQPQAPPP----PQPQPQPPPPPQPQPPPPP--PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ 2981

                         250       260
                  ....*....|....*....|
gi 38201625   269 APPTIPSATPATAPSATSPA 288
Cdd:PHA03247 2982 PAPSREAPASSTPPLTGHSL 3001
rne PRK10811
ribonuclease E; Reviewed
 136-289 2.18e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 49.27  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   136 STPISR-ETGEPYRLSPEPTPLAEPILeVEVTLSKPVPESEFSSSPLQAPT-PLASHTVEIHEPNGMVPSEDLEPEVESS 213
Cdd:PRK10811  844 RYPVVRpQDVQVEEQREAEEVQVQPVV-AEVPVAAAVEPVVSAPVVEAVAEvVEEPVVVAEPQPEEVVVVETTHPEVIAA 922

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   214 PELAPPP-------ACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATS 286
Cdd:PRK10811  923 PVTEQPQvitesdvAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVA 1002


                  ...
gi 38201625   287 PAQ 289
Cdd:PRK10811 1003 PAQ 1005
PHA03247 PHA03247
large tegument protein UL36; Provisional
 111-412 3.70e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 3.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   111 GSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPyrlSPEPTPLAEPILEVEVTLSKPVPESEFSSSP-LQAPTPLAS 189
Cdd:PHA03247 2730 QASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG---PPAPAPPAAPAAGPPRRLTRPAVASLSESREsLPSPWDPAD 2806

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   190 HTVEIHEPNGMVPsedlePEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAvDLSPVSEPEEQAKEVTASMA 269
Cdd:PHA03247 2807 PPAAVLAPAAALP-----PAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGG-DVRRRPPSRSPAAKPAAPAR 2880

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   270 PPTIPSATPATAPSATS----------PAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAA 339
Cdd:PHA03247 2881 PPVRRLARPAVSRSTESfalppdqperPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38201625   340 ATQVAVSVPKRrrkikelnkkeavgdlldafkeanPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDS 412
Cdd:PHA03247 2961 QPWLGALVPGR------------------------VAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWAS 3009
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 164-349 4.06e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 48.37  E-value: 4.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    164 EVTLSKpVPESEFSSSPLQ-----APTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEE 238
Cdd:pfam05109  418 KVIFSK-APESTTTSPTLNttgfaAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRD 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    239 llNG----------------APSPPAVDLSP-VSEPEEQAKEVTASMAPPTIPSATPatAPSATSPAQEEEMEEEEEEEE 301
Cdd:pfam05109  497 --NGteskapdmtsptsavtTPTPNATSPTPaVTTPTPNATSPTLGKTSPTSAVTTP--TPNATSPTPAVTTPTPNATIP 572

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 38201625    302 GEAGEAGEAESEKGGEELLPP---ESTPIPANLSQNLEAAAATQVAVSVPK 349
Cdd:pfam05109  573 TLGKTSPTSAVTTPTPNATSPtvgETSPQANTTNHTLGGTSSTPVVTSPPK 623
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
154-400 4.45e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.31  E-value: 4.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   154 TPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPT 233
Cdd:PRK07003  416 AAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPR 495

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   234 AQPEELLNGAPSPPAVDLSPVSEPEEqakevTASMAPPTiPSATPAtAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESE 313
Cdd:PRK07003  496 AAAPSAATPAAVPDARAPAAASREDA-----PAAAAPPA-PEARPP-TPAAAAPAARAGGAAAALDVLRNAGMRVSSDRG 568

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   314 KGgeellpPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPE 393
Cdd:PRK07003  569 AR------AAAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPPPWEDIPPDDYVPLSA 642


                  ....*..
gi 38201625   394 SEGSGVP 400
Cdd:PRK07003  643 DEGFGGP 649
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 20-281 6.37e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.77  E-value: 6.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    20 DPNQGGKDITEEIMSGARTAS------------TPTPPQTGgglePQANGETPQVAVIVRPDDRSQGAIIADRP------ 81
Cdd:PRK10263  308 DPLLNGAPITEPVAVAAAATTatqswaapvepvTQTPPVAS----VDVPPAQPTVAWQPVPGPQTGEPVIAPAPegypqq 383

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    82 ---GLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPyrlsPEPTPLAE 158
Cdd:PRK10263  384 sqyAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEE----QQSTFAPQ 459

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   159 PILEVEVTLSKPVPESEFSSSPLQAPTPLASHTV-EIHEPNGMVPSEDLEPEVESS-----PELA----PPPAcPSESPV 228
Cdd:PRK10263  460 STYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEpVVEETKPARPPLYYFEEVEEKrarerEQLAawyqPIPE-PVKEPE 538

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 38201625   229 PIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATA 281
Cdd:PRK10263  539 PIKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLATGAAATVAAPVFSLANS 591
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 116-289 9.78e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 46.88  E-value: 9.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    116 LAVLSIPGDTMTTIQMSVEESTPISRetgepyRLSPeptplaepilevevtlSKPVPESEFSSSPL-----QAPTPLASH 190
Cdd:pfam17823  253 LATLAAAAGTVASAAGTINMGDPHAR------RLSP----------------AKHMPSDTMARNPAapmgaQAQGPIIQV 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    191 TVEihepngmvpsedlEPEVESSPELAPPPACPSESPvpiaptaqpeellNGAPSPPAVDLSPVSEPEEQAKEVTASMAP 270
Cdd:pfam17823  311 STD-------------QPVHNTAGEPTPSPSNTTLEP-------------NTPKSVASTNLAVVTTTKAQAKEPSASPVP 364

                          170       180
                   ....*....|....*....|....*.
gi 38201625    271 -------PTIPSATPATAPSATSPAQ 289
Cdd:pfam17823  365 vlhtsmiPEVEATSPTTQPSPLLPTQ 390
PHA03247 PHA03247
large tegument protein UL36; Provisional
 151-287 1.22e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   151 PEPTPLAEPILEVEVTLSKPVPESEFSSSPLQ----APTPLASHTV----EIHEPNGMVPSEDLEPEVESSPELAPPPAC 222
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALpaapAPPAVPAGPAtpggPARPARPPTTAGPPAPAPPAAPAAGPPRRL 2783

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38201625   223 PSESPVPIAPtAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSP 287
Cdd:PHA03247 2784 TRPAVASLSE-SRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847
PHA03377 PHA03377
EBNA-3C; Provisional
 139-449 1.52e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 46.58  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   139 ISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIhEPNGMVPSEdlepevESSPELAP 218
Cdd:PHA03377  408 VSRVPWRKPRTLPWPTPKTHPVKRTLVKTSGRSDEAEQAQSTPERPGPSDQPSVPV-EPAHLTPVE------HTTVILHQ 480

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   219 PPacPSESPVPIAPTAQPEELLNGA-----------------------PSPPAVDLSPVSEPEEQAKEVTASMAPPTIPS 275
Cdd:PHA03377  481 PP--QSPPTVAIKPAPPPSRRRRGAcvvydddiievidvetteeeesvTQPAKPHRKVQDGFQRSGRRQKRATPPKVSPS 558

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   276 atpATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIK 355
Cdd:PHA03377  559 ---DRGPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCKDGPPASGPHEKQPPSSAPRDMAPSVVRMFLR 635

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   356 ELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSgvPPRPEEADETWDSkedKIHNAENIQPGEQKYEYKSD 435
Cdd:PHA03377  636 ERLLEQSTGPKPKSFWEMRAGRDGSGIQQEPSSRRQPATQST--PPRPSWLPSVFVL---PSVDAGRAQPSEESHLSSMS 710

                         330
                  ....*....|....
gi 38201625   436 QWKPLNLEEKKRYD 449
Cdd:PHA03377  711 PTQPISHEEQPRYE 724
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 180-288 1.65e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 46.07  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   180 PLQAPTPLASHTVEIHEPngmVPSEDLEPEVESSPELAPPPAC------------------PSESPVPIAPTAQPEEL-- 239
Cdd:PLN03209  324 PSQRVPPKESDAADGPKP---VPTKPVTPEAPSPPIEEEPPQPkavvprplspytayedlkPPTSPIPTPPSSSPASSks 400

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38201625   240 LNGAPSPPAVDLSPVSE-----PEEQAKEVTASMA-------------PPTIPSATPATA--PSATSPA 288
Cdd:PLN03209  401 VDAVAKPAEPDVVPSPGsasnvPEVEPAQVEAKKTrplspyaryedlkPPTSPSPTAPTGvsPSVSSTS 469
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
204-286 1.70e-04

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 46.15  E-value: 1.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625  204 EDLEPEVESSPELAPPPACPSESPVPIAPTAQPEEllngAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPS 283
Cdd:COG5373   31 EELEAELAEAAEAASAPAEPEPEAAAAATAAAPEA----APAPVPEAPAAPPAAAEAPAPAAAAPPAEAEPAAAPAAASS 106


                 ...
gi 38201625  284 ATS 286
Cdd:COG5373  107 FEE 109
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
112-288 1.86e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.02  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   112 SEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPyrlSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHT 191
Cdd:PRK12323  341 SELALAPDEYAGFTMTLLRMLAFRPGQSGGGAGPA---TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAAR 417

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   192 VEIHEPNGMVPSEDLEPEVESSPELAP-----PPACPSESPVPIAPTAQPeellnGAPSPPAVDLSPVSEPEEQAKEVTA 266
Cdd:PRK12323  418 AVAAAPARRSPAPEALAAARQASARGPggapaPAPAPAAAPAAAARPAAA-----GPRPVAAAAAAAPARAAPAAAPAPA 492

                         170       180
                  ....*....|....*....|....*
gi 38201625   267 SMAPP---TIPSATPATAPSATSPA 288
Cdd:PRK12323  493 DDDPPpweELPPEFASPAPAQPDAA 517
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 144-287 6.51e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 44.32  E-value: 6.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   144 GEPYRLSPEPTPLAEPilevEVTLSKPVPESEFSSSPLQAPTPLAShtveihepngMVPSEDLEPEVESSPELAPPPACP 223
Cdd:PRK14951  369 AAEAAAPAEKKTPARP----EAAAPAAAPVAQAAAAPAPAAAPAAA----------ASAPAAPPAAAPPAPVAAPAAAAP 434

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 38201625   224 SESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEeqakevTASMAPPTIPSATPATAPSATSP 287
Cdd:PRK14951  435 AAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPE------PAVASAAPAPAAAPAAARLTPTE 492
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 168-403 9.11e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 9.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    168 SKPVP---ESEFSSSPLQapTPLASHTVEIHEPNGMVPSEDLEPEVESS-PELAPPPACPSESPVPIAPTAQPeellnga 243
Cdd:pfam03154  147 SIPSPqdnESDSDSSAQQ--QILQTQPPVLQAQSGAASPPSPPPPGTTQaATAGPTPSAPSVPPQGSPATSQP------- 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    244 PSPPAVDLSPVSEPEEqakevTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELL--- 320
Cdd:pfam03154  218 PNQTQSTAAPHTLIQQ-----TPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMqhp 292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    321 -PPESTPIPANLSQNlEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA-------------------VPEV 380
Cdd:pfam03154  293 vPPQPFPLTPQSSQS-QVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAplsmphikpppttpipqlpNPQS 371

                          250       260
                   ....*....|....*....|...
gi 38201625    381 ENQPPAGSNPGPESEGSGVPPRP 403
Cdd:pfam03154  372 HKHPPHLSGPSPFQMNSNLPPPP 394
rne PRK10811
ribonuclease E; Reviewed
 180-348 2.55e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 42.33  E-value: 2.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   180 PLQAPTPL---------ASHTVEIHEP-----------NGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEEL 239
Cdd:PRK10811  820 PTQSPMPLtvacaspemASGKVWIRYPvvrpqdvqveeQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPV 899

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   240 LNGAPSPPAVDlsPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEEL 319
Cdd:PRK10811  900 VVAEPQPEEVV--VVETTHPEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVA 977

                         170       180
                  ....*....|....*....|....*....
gi 38201625   320 LPPESTPIPANLSQNLEAAAATQVAVSVP 348
Cdd:PRK10811  978 QPAAPVVAEVAAEVETVTAVEPEVAPAQV 1006
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 168-289 2.59e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   168 SKPVPESEfSSSPLQAPTPLASHTVEIHEPNGMVPsedlePEVESSPELAPPPACPSESPVPIAPTAQPEELlnGAPSPP 247
Cdd:PRK14951  372 AAAPAEKK-TPARPEAAAPAAAPVAQAAAAPAPAA-----APAAAASAPAAPPAAAPPAPVAAPAAAAPAAA--PAAAPA 443

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 38201625   248 AVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQ 289
Cdd:PRK14951  444 AVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAA 485
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
110-286 2.88e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   110 PGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPileVEVTLSKPVPESEFSSSPLQAPTPLAS 189
Cdd:PRK12323  387 PAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAA---RQASARGPGGAPAPAPAPAAAPAAAAR 463

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   190 HTVeihepngmvpsedlepevessPELAPPPACPSESPVPIAPTAQP----------EELLNGAPSPPAVDLSPVSEPEE 259
Cdd:PRK12323  464 PAA---------------------AGPRPVAAAAAAAPARAAPAAAPapadddpppwEELPPEFASPAPAQPDAAPAGWV 522

                         170       180
                  ....*....|....*....|....*..
gi 38201625   260 QAKEVTASMAPPTIPSATPATAPSATS 286
Cdd:PRK12323  523 AESIPDPATADPDDAFETLAPAPAAAP 549
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 113-289 4.44e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.61  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   113 EPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYrLSPEP------TPLAEPILEVEVTLSKPVPESEFSSSPLQAPTP 186
Cdd:PRK10263  338 EPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPV-IAPAPegypqqSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPA 416

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   187 LASHTVEihEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEellngapsppavdlSPVSEPEEQAKEVTA 266
Cdd:PRK10263  417 QQPYYAP--APEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTE--------------QTYQQPAAQEPLYQQ 480

                         170       180
                  ....*....|....*....|...
gi 38201625   267 SMAPPTIPSATPATAPSATSPAQ 289
Cdd:PRK10263  481 PQPVEQQPVVEPEPVVEETKPAR 503
Rib_recp_KP_reg pfam05104
Ribosome receptor lysine/proline rich region; This highly conserved region is found towards ...
 195-288 5.28e-03

Ribosome receptor lysine/proline rich region; This highly conserved region is found towards the C-terminus of the transmembrane domain. The function is unclear.


Pssm-ID: 461548 [Multi-domain]  Cd Length: 140  Bit Score: 38.95  E-value: 5.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    195 HEPNGMVPSEDLEPEVESSP-ELAPPPACPSESPVPiAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTI 273
Cdd:pfam05104   44 EKPNGKLPESEQADESEEEPrEFKTPDEAPSAALEP-EPVPTPVPAPVEPEPAPPSESPAPSPKEKKKKEKKSAKVEPAE 122

                           90
                   ....*....|....*
gi 38201625    274 PSATPATAPSATSPA 288
Cdd:pfam05104  123 TPEAVQPKPALEKEE 137
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 146-289 7.62e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 7.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625    146 PYRLSPEPTPLAEPILEVEVTLSKPvpesEFSSSPLQAPTPLASHTVEIHEPngmVPSEDLEPeveSSPELAPPPACPSE 225
Cdd:pfam03154  414 PLQLMPQSQQLPPPPAQPPVLTQSQ----SLPPPAASHPPTSGLHQVPSQSP---FPQHPFVP---GGPPPITPPSGPPT 483

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38201625    226 SPVPIAPTAQPEELLNGA-----PSPPAVDLSPV---SEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQ 289
Cdd:pfam03154  484 STSSAMPGIQPPSSASVSssgpvPAAVSCPLPPVqikEEALDEAEEPESPPPPPRSPSPEPTVVNTPSHASQ 555
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
159-272 7.78e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 40.72  E-value: 7.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   159 PILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEE 238
Cdd:PRK14948  348 PRLWLEVTLLGLLPSAFISEIANASAPANPTPAPNPSPPPAPIQPSAPKTKQAATTPSPPPAKASPPIPVPAEPTEPSPT 427

                          90       100       110
                  ....*....|....*....|....*....|....
gi 38201625   239 llngaPSPPAVDLSPVSEPEEQAKEVTASMAPPT 272
Cdd:PRK14948  428 -----PPANAANAPPSLNLEELWQQILAKLELPS 456
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 179-289 8.56e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 40.22  E-value: 8.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625  179 SPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESspelAPPPACPSESPVPIAPTAQPEellNGAPSPPAVDLSPVSEPE 258
Cdd:COG3266  253 SALKAPSQASSASAPATTSLGEQQEVSLPPAVAA----QPAAAAAAQPSAVALPAAPAA---AAAAAAPAEAAAPQPTAA 325

                         90       100       110
                 ....*....|....*....|....*....|.
gi 38201625  259 EQAKEVTASMAPPTIPSATPATAPSATSPAQ 289
Cdd:COG3266  326 KPVVTETAAPAAPAPEAAAAAAAPAAPAVAK 356
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 163-281 8.82e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.56  E-value: 8.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38201625   163 VEVTLSK-PVPESEFSSSPlqAPTPLASHTVEIHEPNGMVPseDLEPEVESSPELAPPPacpsesPVPIAPTAQPEElln 241
Cdd:PRK14950  356 IEALLVPvPAPQPAKPTAA--APSPVRPTPAPSTRPKAAAA--ANIPPKEPVRETATPP------PVPPRPVAPPVP--- 422

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 38201625   242 gAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATA 281
Cdd:PRK14950  423 -HTPESAPKLTRAAIPVDEKPKYTPPAPPKEEEKALIADG 461
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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