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Conserved domains on  [gi|464402377|ref|NP_877435|]
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WD repeat-containing protein 72 isoform a [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-595 1.28e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 84.69  E-value: 1.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  404 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEGGSLVKdspphkVLKGHHQSVTSLLYPHglssklDQSWML 483
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLR------TLKGHTGPVRDVAASA------DGTYLA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  484 SGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMI 563
Cdd:cd00200    68 SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 464402377  564 KWHPVENFLIVGCADDSVYIWEIETG----TLERHE 595
Cdd:cd00200   142 AFSPDGTFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-191 3.19e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 3.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   13 QKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLararDFS-KQPYIVSAAENGEMCV 91
Cdd:cd00200    47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSV----AFSpDGRILSSSSRDKTIKV 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   92 WNVTNGQCmeKATLPYrHTAICyYHCSFrmTGEGWLLCCGEY-QDVLIIDAKTLAVVHSFRSSQfpDWINCMCIVHSmri 170
Cdd:cd00200   120 WDVETGKC--LTTLRG-HTDWV-NSVAF--SPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHT--GEVNSVAFSPD--- 188

                         170       180
                  ....*....|....*....|.
gi 464402377  171 qEDSLLVVSVAGELKVWDLSS 191
Cdd:cd00200   189 -GEKLLSSSSDGTIKLWDLST 208
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-595 1.28e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.69  E-value: 1.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  404 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEGGSLVKdspphkVLKGHHQSVTSLLYPHglssklDQSWML 483
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLR------TLKGHTGPVRDVAASA------DGTYLA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  484 SGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMI 563
Cdd:cd00200    68 SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 464402377  564 KWHPVENFLIVGCADDSVYIWEIETG----TLERHE 595
Cdd:cd00200   142 AFSPDGTFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 COG2319
WD40 repeat [General function prediction only];
419-602 6.80e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 6.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  419 LICGCEDGTIiitqalnaakaRL--LEGGSLVKdspphkVLKGHHQSVTSLLYphglSSklDQSWMLSGDLDSCVILWDI 496
Cdd:COG2319   219 LASGSADGTV-----------RLwdLATGKLLR------TLTGHSGSVRSVAF----SP--DGRLLASGSADGTVRLWDL 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  497 FTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGC 576
Cdd:COG2319   276 ATGELLRTLTGHSGGVNSVAFSPD-----GKLLASG-SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                         170       180
                  ....*....|....*....|....*.
gi 464402377  577 ADDSVYIWEIETGTLERHETGERARI 602
Cdd:COG2319   350 DDGTVRLWDLATGELLRTLTGHTGAV 375
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-191 3.19e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 3.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   13 QKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLararDFS-KQPYIVSAAENGEMCV 91
Cdd:cd00200    47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSV----AFSpDGRILSSSSRDKTIKV 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   92 WNVTNGQCmeKATLPYrHTAICyYHCSFrmTGEGWLLCCGEY-QDVLIIDAKTLAVVHSFRSSQfpDWINCMCIVHSmri 170
Cdd:cd00200   120 WDVETGKC--LTTLRG-HTDWV-NSVAF--SPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHT--GEVNSVAFSPD--- 188

                         170       180
                  ....*....|....*....|.
gi 464402377  171 qEDSLLVVSVAGELKVWDLSS 191
Cdd:cd00200   189 -GEKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
3-191 1.63e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 1.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377    3 TSLQAVALWGQKAPPHSITaimITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLArardFSkqP-- 78
Cdd:COG2319   109 TGLLLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLA-----TGKLLrtLTGHSGAVTSVA----FS--Pdg 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   79 -YIVSAAENGEMCVWNVTNGQCMekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPd 157
Cdd:COG2319   175 kLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGS- 248

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 464402377  158 wincmciVHSMRIQEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319   249 -------VRSVAFSPDGRLLASGSadGTVRLWDLAT 277
WD40 pfam00400
WD domain, G-beta repeat;
453-495 7.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 7.27e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 464402377   453 PHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWD 495
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-595 1.28e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.69  E-value: 1.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  404 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEGGSLVKdspphkVLKGHHQSVTSLLYPHglssklDQSWML 483
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLR------TLKGHTGPVRDVAASA------DGTYLA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  484 SGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMI 563
Cdd:cd00200    68 SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 464402377  564 KWHPVENFLIVGCADDSVYIWEIETG----TLERHE 595
Cdd:cd00200   142 AFSPDGTFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 COG2319
WD40 repeat [General function prediction only];
419-602 6.80e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 6.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  419 LICGCEDGTIiitqalnaakaRL--LEGGSLVKdspphkVLKGHHQSVTSLLYphglSSklDQSWMLSGDLDSCVILWDI 496
Cdd:COG2319   219 LASGSADGTV-----------RLwdLATGKLLR------TLTGHSGSVRSVAF----SP--DGRLLASGSADGTVRLWDL 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  497 FTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGC 576
Cdd:COG2319   276 ATGELLRTLTGHSGGVNSVAFSPD-----GKLLASG-SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                         170       180
                  ....*....|....*....|....*.
gi 464402377  577 ADDSVYIWEIETGTLERHETGERARI 602
Cdd:COG2319   350 DDGTVRLWDLATGELLRTLTGHTGAV 375
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 412-595 2.29e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 2.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  412 YIPSLDKLICGCEDGTIIITQalnaakarlleggslVKDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCV 491
Cdd:cd00200    59 ASADGTYLASGSSDKTIRLWD---------------LETGECVRTLTGHTSYVSSVAFSP------DGRILSSSSRDKTI 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  492 ILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENF 571
Cdd:cd00200   118 KVWDVETGKCLTTLRGHTDWVNSVAFSPDG------TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEK 191

                         170       180
                  ....*....|....*....|....*...
gi 464402377  572 LIVGCADDSVYIWEIETG----TLERHE 595
Cdd:cd00200   192 LLSSSSDGTIKLWDLSTGkclgTLRGHE 219
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-191 3.19e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 3.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   13 QKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLararDFS-KQPYIVSAAENGEMCV 91
Cdd:cd00200    47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSV----AFSpDGRILSSSSRDKTIKV 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   92 WNVTNGQCmeKATLPYrHTAICyYHCSFrmTGEGWLLCCGEY-QDVLIIDAKTLAVVHSFRSSQfpDWINCMCIVHSmri 170
Cdd:cd00200   120 WDVETGKC--LTTLRG-HTDWV-NSVAF--SPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHT--GEVNSVAFSPD--- 188

                         170       180
                  ....*....|....*....|.
gi 464402377  171 qEDSLLVVSVAGELKVWDLSS 191
Cdd:cd00200   189 -GEKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
419-602 4.53e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 4.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  419 LICGCEDGTIIItqaLNAAKARLLeggslvkdspphKVLKGHHQSVTSLLY-PHGlsskldqSWMLSGDLDSCVILWDIF 497
Cdd:COG2319   177 LASGSDDGTVRL---WDLATGKLL------------RTLTGHTGAVRSVAFsPDG-------KLLASGSADGTVRLWDLA 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  498 TEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCA 577
Cdd:COG2319   235 TGKLLRTLTGHSGSVRSVAFSPD-----GRLLASG-SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                         170       180
                  ....*....|....*....|....*
gi 464402377  578 DDSVYIWEIETGTLERHETGERARI 602
Cdd:COG2319   309 DGTVRLWDLATGKLLRTLTGHTGAV 333
WD40 COG2319
WD40 repeat [General function prediction only];
3-191 1.63e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 1.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377    3 TSLQAVALWGQKAPPHSITaimITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLArardFSkqP-- 78
Cdd:COG2319   109 TGLLLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLA-----TGKLLrtLTGHSGAVTSVA----FS--Pdg 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   79 -YIVSAAENGEMCVWNVTNGQCMekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPd 157
Cdd:COG2319   175 kLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGS- 248

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 464402377  158 wincmciVHSMRIQEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319   249 -------VRSVAFSPDGRLLASGSadGTVRLWDLAT 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 385-597 3.19e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.43  E-value: 3.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  385 DTMSQSIIDYFSGLKDGagtavVTSSEYIPSlDKLICGC-EDGTIIITQalnaakarlleggslVKDSPPHKVLKGHHQS 463
Cdd:cd00200    79 DLETGECVRTLTGHTSY-----VSSVAFSPD-GRILSSSsRDKTIKVWD---------------VETGKCLTTLRGHTDW 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  464 VTSLLYPHglssklDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLH 543
Cdd:cd00200   138 VNSVAFSP------DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-----GEKLLSS-SSDGTIKLWD 205

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 464402377  544 LEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETG----TLERHETG 597
Cdd:cd00200   206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGecvqTLSGHTNS 263
WD40 COG2319
WD40 repeat [General function prediction only];
403-602 3.21e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.47  E-value: 3.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  403 GTAVVTSSEYIPSLDKLICGCEDGTIiitqalnaakaRLLEggslVKDSPPHKVLKGHHQSVTSLLYphglSSklDQSWM 482
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTV-----------RLWD----LATGLLLRTLTGHTGAVRSVAF----SP--DGKTL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  483 LSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICcVCGDHSVALLHLEGKSCLLHARKHLFPVRM 562
Cdd:COG2319   136 ASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-----GKLLAS-GSDDGTVRLWDLATGKLLRTLTGHTGAVRS 209

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 464402377  563 IKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARI 602
Cdd:COG2319   210 VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249
WD40 COG2319
WD40 repeat [General function prediction only];
419-588 2.96e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 2.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  419 LICGCEDGTIiitqalnaakaRL--LEGGSLVKdspphkVLKGHHQSVTSLLY-PHGlsskldqSWMLSGDLDSCVILWD 495
Cdd:COG2319   261 LASGSADGTV-----------RLwdLATGELLR------TLTGHSGGVNSVAFsPDG-------KLLASGSDDGTVRLWD 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  496 IFTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVG 575
Cdd:COG2319   317 LATGKLLRTLTGHTGAVRSVAFSPD-----GKTLASG-SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390

                         170
                  ....*....|...
gi 464402377  576 CADDSVYIWEIET 588
Cdd:COG2319   391 SADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
14-191 1.40e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   14 KAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISakeLLFGHSASVTCLArardFSkqP---YIVSAAENGEMC 90
Cdd:COG2319   243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR---TLTGHSGGVNSVA----FS--PdgkLLASGSDDGTVR 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   91 VWNVTNGQCMekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRssQFPDWincmciVHSMRI 170
Cdd:COG2319   314 LWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-TLASGSDDGTVRLWDLATGELLRTLT--GHTGA------VTSVAF 380

                         170       180
                  ....*....|....*....|...
gi 464402377  171 QEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319   381 SPDGRTLASGSadGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
456-602 2.19e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 2.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  456 VLKGHHQSVTSLLYPhglsskLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICcVCG 535
Cdd:COG2319    73 TLLGHTAAVLSVAFS------PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD-----GKTLAS-GSA 140

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 464402377  536 DHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARI 602
Cdd:COG2319   141 DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-585 8.87e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 8.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  404 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEGGSLVKdspphkVLKGHHQSVTSL-LYPhglssklDQSWM 482
Cdd:cd00200   135 TDWVNSVAFSPDGTFVASSSQDGTIKLWD---------LRTGKCVA------TLTGHTGEVNSVaFSP-------DGEKL 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  483 LSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRM 562
Cdd:cd00200   193 LSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTS 266

                         170       180
                  ....*....|....*....|...
gi 464402377  563 IKWHPVENFLIVGCADDSVYIWE 585
Cdd:cd00200   267 LAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
18-191 3.20e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 3.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   18 HSITAIMITDDQRTIVTGSQEGQLCLWNLSHELkisAKELLFGHSASVTCLARARDfskQPYIVSAAENGEMCVWNVTNG 97
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFSPD---GKTLASGSADGTVRLWDLATG 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   98 QCMekATLPyRHTAICYyhcSFRMTGEG-WLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPdwincmciVHSMRIQEDSLL 176
Cdd:COG2319   153 KLL--RTLT-GHSGAVT---SVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGA--------VRSVAFSPDGKL 218

                         170
                  ....*....|....*..
gi 464402377  177 VVSVA--GELKVWDLSS 191
Cdd:COG2319   219 LASGSadGTVRLWDLAT 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-191 1.56e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 1.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   58 LFGHSASVTCLArardFS-KQPYIVSAAENGEMCVWNVTNGQCMEKATLpyrHTaICYYHCSFRMTGEgWLLCCGEYQDV 136
Cdd:cd00200     5 LKGHTGGVTCVA----FSpDGKLLATGSGDGTIKVWDLETGELLRTLKG---HT-GPVRDVAASADGT-YLASGSSDKTI 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 464402377  137 LIIDAKTLAVVHSFRssQFPDWINCMCIVHSMRIqedsLLVVSVAGELKVWDLSS 191
Cdd:cd00200    76 RLWDLETGECVRTLT--GHTSYVSSVAFSPDGRI----LSSSSRDKTIKVWDVET 124
WD40 COG2319
WD40 repeat [General function prediction only];
473-602 7.13e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 7.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  473 LSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPekfklrGEQIICCVCGDHSVALLHLEGKSCLLH 552
Cdd:COG2319    42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP------DGRLLASASADGTVRLWDLATGLLLRT 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 464402377  553 ARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARI 602
Cdd:COG2319   116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-114 1.19e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 1.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   19 SITAIMITDDQRTIVTGSQEGQLCLWNLShelKISAKELLFGHSASVTCLArardFSKQPYIV-SAAENGEMCVWNVTNG 97
Cdd:cd00200   179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKCLGTLRGHENGVNSVA----FSPDGYLLaSGSEDGTIRVWDLRTG 251

                          90
                  ....*....|....*..
gi 464402377   98 QCMekATLPyRHTAICY 114
Cdd:cd00200   252 ECV--QTLS-GHTNSVT 265
WD40 COG2319
WD40 repeat [General function prediction only];
10-96 8.21e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 8.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377   10 LWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLARARDfskQPYIVSAAENG 87
Cdd:COG2319   323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA-----TGELLrtLTGHTGAVTSVAFSPD---GRTLASGSADG 394


                  ....*....
gi 464402377   88 EMCVWNVTN 96
Cdd:COG2319   395 TVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 556-613 1.55e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 1.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 464402377  556 HLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARI--ILNCCDDSQLV 613
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVrdVAASADGTYLA 67
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-93 3.78e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 3.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 464402377   19 SITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLArardFSKQ-PYIVSAAENGEMCVWN 93
Cdd:cd00200   221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---LSGHTNSVTSLA----WSPDgKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
453-495 7.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 7.27e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 464402377   453 PHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWD 495
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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