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Conserved domains on  [gi|148743778|ref|NP_851785|]
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CKLF-like MARVEL transmembrane domain-containing protein 1 isoform 14 [Homo sapiens]

Protein Classification

MARVEL/CASP family protein( domain architecture ID 2507)

MARVEL (MAL and related proteins for vesicle trafficking and membrane link)/CASP (Casparian strip membrane protein) family protein similar to Arabidopsis thaliana CASP-like protein 1B2

Gene Ontology:  GO:0016020
PubMed:  21593871

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MARVEL super family cl04571
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 131-208 9.95e-03

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


The actual alignment was detected with superfamily member pfam01284:

Pssm-ID: 383772  Cd Length: 136  Bit Score: 35.38  E-value: 9.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743778  131 FSFSPTGMLKILRLSLILGALACFI--------ITQANESFITITSLEICIVVFFILIYVLTLHHLLTYLhWPLLDLTNS 202
Cdd:pfam01284   1 FLLTPLGILRILQLVFAIIVLGLIAsliayagsYPSAVNFAVFVAVFSFLIALFFLLLYLFGYSYFPSIA-WPLIDLIFD 79


                  ....*.
gi 148743778  203 IITAVF 208
Cdd:pfam01284  80 ALAALF 85
 
Name Accession Description Interval E-value
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 131-208 9.95e-03

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


Pssm-ID: 366555  Cd Length: 136  Bit Score: 35.38  E-value: 9.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743778  131 FSFSPTGMLKILRLSLILGALACFI--------ITQANESFITITSLEICIVVFFILIYVLTLHHLLTYLhWPLLDLTNS 202
Cdd:pfam01284   1 FLLTPLGILRILQLVFAIIVLGLIAsliayagsYPSAVNFAVFVAVFSFLIALFFLLLYLFGYSYFPSIA-WPLIDLIFD 79


                  ....*.
gi 148743778  203 IITAVF 208
Cdd:pfam01284  80 ALAALF 85
 
Name Accession Description Interval E-value
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 131-208 9.95e-03

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


Pssm-ID: 366555  Cd Length: 136  Bit Score: 35.38  E-value: 9.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743778  131 FSFSPTGMLKILRLSLILGALACFI--------ITQANESFITITSLEICIVVFFILIYVLTLHHLLTYLhWPLLDLTNS 202
Cdd:pfam01284   1 FLLTPLGILRILQLVFAIIVLGLIAsliayagsYPSAVNFAVFVAVFSFLIALFFLLLYLFGYSYFPSIA-WPLIDLIFD 79


                  ....*.
gi 148743778  203 IITAVF 208
Cdd:pfam01284  80 ALAALF 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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