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Conserved domains on  [gi|31342051|ref|NP_851597|]
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brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform 1 [Rattus norvegicus]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1718 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1042.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051    11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051    73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETVCNCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEnqvlqeARELEKPIQskpqsPVIQATAGSPkfsr 232
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRME------ADSSTVPIQ-----PIVVAELMEP---- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   233 lkqsqAQSKPTTPEKTELPNG---------DHARSSLGKVNSENGEAHRerGSSISGRAEPSGGSDNGAQEVVKDILEDV 303
Cdd:PLN03076  235 -----AEKSDSDTSMTQFVQGfitkimqdiDGVLNPATAGKSSGSGAHD--GAFETTATVETTNPADLLDSTDKDMLDAK 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   304 V--TSAVKEAAEKQGlpepdqapgvpecqectvppavDENSQTNGIADDrqslssadnlepDAQghpvaARFSHILQKDA 381
Cdd:PLN03076  308 YweISMYKSALEGRK----------------------GELADGEVEKDD------------DLE-----VQIGNKLRRDA 348

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   382 FLVFRSLCKLSMK-PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFE 460
Cdd:PLN03076  349 FLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQ 426

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   461 LSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFER 539
Cdd:PLN03076  427 LSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFER 506

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   540 LVNDLSKIAQG-RSGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQAtlgqERLPDQEMGDGKG-LDM 616
Cdd:PLN03076  507 MVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsLPV 582

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   617 ARRCSVTSVESTVSSGTQTAIPDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLD 696
Cdd:PLN03076  583 ANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLN 662

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   697 STQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASADTA 776
Cdd:PLN03076  663 KTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSADTA 740

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   777 YVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKE------TKEHTMATK--- 847
Cdd:PLN03076  741 YVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEddlvpqQKQSANSNRilg 820

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   848 -STKQNVASEKQRRllyNVEMEQ----MAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDT 922
Cdd:PLN03076  821 lDSILNIVIRKRGE---DSYMETsddlIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDE 897

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   923 EVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEILKC 1002
Cdd:PLN03076  898 VVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHILTC 974

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1003 ISQLELAQLIGTG--------------------VKTRYLSGSGREREGSLKGHSLAGEE--FMGLGLGNLVSGGVDKRQM 1060
Cdd:PLN03076  975 VSRFEHLHLLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTSEQM 1054

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1061 AS------FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRI 1134
Cdd:PLN03076 1055 NNlvsnlnMLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNRI 1127

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1135 RLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCI 1214
Cdd:PLN03076 1128 RLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCV 1207

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1215 AQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTS 1294
Cdd:PLN03076 1208 SQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDIS 1287

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1295 MEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVRTRG 1358
Cdd:PLN03076 1288 LNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIRKSA 1367

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1359 LTVMFEIMKSYGHTFAKHWWQDLFRIV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALYAICDVF 1420
Cdd:PLN03076 1368 LQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQLVVDLF 1447

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1421 TQFYEALHEvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFRTTIPHVLLTWRPAG 1500
Cdd:PLN03076 1448 VKFYPTVNP-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVSGEY 1526

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1501 MEEEVSDrhlDVDLDRQSLSSIDRNASERGQS-QLSNPTDDSwkgapyanqkllaslliKC--VVQLELIQTIdnivfyp 1577
Cdd:PLN03076 1527 MPAENIQ---DSENAEAASSSTADNDAEAERSrRLYAAISDA-----------------KCraAVQLLLIQAV------- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1578 atskkedaehmvaaqqdtldadihieTENQGMYK-FMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSK- 1655
Cdd:PLN03076 1580 --------------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQd 1633

                        1770      1780      1790      1800      1810      1820
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31342051  1656 PNLLKQETSSLACCLRILFRMYVDENRRDSWGEIQQRLLTVCSEALAYFItvnsESHREAWTS 1718
Cdd:PLN03076 1634 PPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1718 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1042.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051    11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051    73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETVCNCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEnqvlqeARELEKPIQskpqsPVIQATAGSPkfsr 232
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRME------ADSSTVPIQ-----PIVVAELMEP---- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   233 lkqsqAQSKPTTPEKTELPNG---------DHARSSLGKVNSENGEAHRerGSSISGRAEPSGGSDNGAQEVVKDILEDV 303
Cdd:PLN03076  235 -----AEKSDSDTSMTQFVQGfitkimqdiDGVLNPATAGKSSGSGAHD--GAFETTATVETTNPADLLDSTDKDMLDAK 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   304 V--TSAVKEAAEKQGlpepdqapgvpecqectvppavDENSQTNGIADDrqslssadnlepDAQghpvaARFSHILQKDA 381
Cdd:PLN03076  308 YweISMYKSALEGRK----------------------GELADGEVEKDD------------DLE-----VQIGNKLRRDA 348

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   382 FLVFRSLCKLSMK-PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFE 460
Cdd:PLN03076  349 FLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQ 426

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   461 LSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFER 539
Cdd:PLN03076  427 LSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFER 506

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   540 LVNDLSKIAQG-RSGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQAtlgqERLPDQEMGDGKG-LDM 616
Cdd:PLN03076  507 MVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsLPV 582

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   617 ARRCSVTSVESTVSSGTQTAIPDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLD 696
Cdd:PLN03076  583 ANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLN 662

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   697 STQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASADTA 776
Cdd:PLN03076  663 KTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSADTA 740

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   777 YVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKE------TKEHTMATK--- 847
Cdd:PLN03076  741 YVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEddlvpqQKQSANSNRilg 820

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   848 -STKQNVASEKQRRllyNVEMEQ----MAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDT 922
Cdd:PLN03076  821 lDSILNIVIRKRGE---DSYMETsddlIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDE 897

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   923 EVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEILKC 1002
Cdd:PLN03076  898 VVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHILTC 974

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1003 ISQLELAQLIGTG--------------------VKTRYLSGSGREREGSLKGHSLAGEE--FMGLGLGNLVSGGVDKRQM 1060
Cdd:PLN03076  975 VSRFEHLHLLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTSEQM 1054

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1061 AS------FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRI 1134
Cdd:PLN03076 1055 NNlvsnlnMLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNRI 1127

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1135 RLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCI 1214
Cdd:PLN03076 1128 RLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCV 1207

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1215 AQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTS 1294
Cdd:PLN03076 1208 SQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDIS 1287

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1295 MEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVRTRG 1358
Cdd:PLN03076 1288 LNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIRKSA 1367

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1359 LTVMFEIMKSYGHTFAKHWWQDLFRIV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALYAICDVF 1420
Cdd:PLN03076 1368 LQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQLVVDLF 1447

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1421 TQFYEALHEvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFRTTIPHVLLTWRPAG 1500
Cdd:PLN03076 1448 VKFYPTVNP-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVSGEY 1526

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1501 MEEEVSDrhlDVDLDRQSLSSIDRNASERGQS-QLSNPTDDSwkgapyanqkllaslliKC--VVQLELIQTIdnivfyp 1577
Cdd:PLN03076 1527 MPAENIQ---DSENAEAASSSTADNDAEAERSrRLYAAISDA-----------------KCraAVQLLLIQAV------- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1578 atskkedaehmvaaqqdtldadihieTENQGMYK-FMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSK- 1655
Cdd:PLN03076 1580 --------------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQd 1633

                        1770      1780      1790      1800      1810      1820
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31342051  1656 PNLLKQETSSLACCLRILFRMYVDENRRDSWGEIQQRLLTVCSEALAYFItvnsESHREAWTS 1718
Cdd:PLN03076 1634 PPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 650-834 2.73e-96

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 307.85  E-value: 2.73e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051    650 QKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEF 729
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051    730 VSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 809
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 31342051    810 GINDSKDLPEEYLSSIYEEIEGKKI 834
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 650-834 4.81e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 276.03  E-value: 4.81e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  650 QKEIIEHGIELFNKKPKRGIQFLQEQGML-GAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKE 728
Cdd:cd00171    1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  729 FVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 808
Cdd:cd00171   81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                        170       180
                 ....*....|....*....|....*.
gi 31342051  809 RGINDSKDLPEEYLSSIYEEIEGKKI 834
Cdd:cd00171  160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 648-834 1.95e-79

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 259.91  E-value: 1.95e-79
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051     648 KQQKEIIEHGIELFNKKPKRGIQFLQEQGMLG-AAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCE 726
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLAnEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051     727 KEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIK 806
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 31342051     807 MNRGINDSKDLPEEYLSSIYEEIEGKKI 834
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1718 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1042.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051    11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051    73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETVCNCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEnqvlqeARELEKPIQskpqsPVIQATAGSPkfsr 232
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRME------ADSSTVPIQ-----PIVVAELMEP---- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   233 lkqsqAQSKPTTPEKTELPNG---------DHARSSLGKVNSENGEAHRerGSSISGRAEPSGGSDNGAQEVVKDILEDV 303
Cdd:PLN03076  235 -----AEKSDSDTSMTQFVQGfitkimqdiDGVLNPATAGKSSGSGAHD--GAFETTATVETTNPADLLDSTDKDMLDAK 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   304 V--TSAVKEAAEKQGlpepdqapgvpecqectvppavDENSQTNGIADDrqslssadnlepDAQghpvaARFSHILQKDA 381
Cdd:PLN03076  308 YweISMYKSALEGRK----------------------GELADGEVEKDD------------DLE-----VQIGNKLRRDA 348

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   382 FLVFRSLCKLSMK-PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFE 460
Cdd:PLN03076  349 FLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQ 426

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   461 LSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFER 539
Cdd:PLN03076  427 LSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFER 506

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   540 LVNDLSKIAQG-RSGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQAtlgqERLPDQEMGDGKG-LDM 616
Cdd:PLN03076  507 MVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsLPV 582

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   617 ARRCSVTSVESTVSSGTQTAIPDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLD 696
Cdd:PLN03076  583 ANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLN 662

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   697 STQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASADTA 776
Cdd:PLN03076  663 KTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSADTA 740

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   777 YVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKE------TKEHTMATK--- 847
Cdd:PLN03076  741 YVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEddlvpqQKQSANSNRilg 820

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   848 -STKQNVASEKQRRllyNVEMEQ----MAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDT 922
Cdd:PLN03076  821 lDSILNIVIRKRGE---DSYMETsddlIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDE 897

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   923 EVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEILKC 1002
Cdd:PLN03076  898 VVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHILTC 974

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1003 ISQLELAQLIGTG--------------------VKTRYLSGSGREREGSLKGHSLAGEE--FMGLGLGNLVSGGVDKRQM 1060
Cdd:PLN03076  975 VSRFEHLHLLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTSEQM 1054

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1061 AS------FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRI 1134
Cdd:PLN03076 1055 NNlvsnlnMLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNRI 1127

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1135 RLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCI 1214
Cdd:PLN03076 1128 RLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCV 1207

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1215 AQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTS 1294
Cdd:PLN03076 1208 SQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDIS 1287

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1295 MEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVRTRG 1358
Cdd:PLN03076 1288 LNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIRKSA 1367

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1359 LTVMFEIMKSYGHTFAKHWWQDLFRIV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALYAICDVF 1420
Cdd:PLN03076 1368 LQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQLVVDLF 1447

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1421 TQFYEALHEvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFRTTIPHVLLTWRPAG 1500
Cdd:PLN03076 1448 VKFYPTVNP-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVSGEY 1526

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1501 MEEEVSDrhlDVDLDRQSLSSIDRNASERGQS-QLSNPTDDSwkgapyanqkllaslliKC--VVQLELIQTIdnivfyp 1577
Cdd:PLN03076 1527 MPAENIQ---DSENAEAASSSTADNDAEAERSrRLYAAISDA-----------------KCraAVQLLLIQAV------- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  1578 atskkedaehmvaaqqdtldadihieTENQGMYK-FMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSK- 1655
Cdd:PLN03076 1580 --------------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQd 1633

                        1770      1780      1790      1800      1810      1820
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31342051  1656 PNLLKQETSSLACCLRILFRMYVDENRRDSWGEIQQRLLTVCSEALAYFItvnsESHREAWTS 1718
Cdd:PLN03076 1634 PPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 650-834 2.73e-96

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 307.85  E-value: 2.73e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051    650 QKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEF 729
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051    730 VSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 809
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 31342051    810 GINDSKDLPEEYLSSIYEEIEGKKI 834
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 650-834 4.81e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 276.03  E-value: 4.81e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  650 QKEIIEHGIELFNKKPKRGIQFLQEQGML-GAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKE 728
Cdd:cd00171    1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051  729 FVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 808
Cdd:cd00171   81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                        170       180
                 ....*....|....*....|....*.
gi 31342051  809 RGINDSKDLPEEYLSSIYEEIEGKKI 834
Cdd:cd00171  160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 648-834 1.95e-79

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 259.91  E-value: 1.95e-79
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051     648 KQQKEIIEHGIELFNKKPKRGIQFLQEQGMLG-AAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCE 726
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLAnEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051     727 KEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIK 806
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 31342051     807 MNRGINDSKDLPEEYLSSIYEEIEGKKI 834
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1561-1767 9.31e-58

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 197.46  E-value: 9.31e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   1561 VVQLELIQTIDNIVfypatskkedaehmvaaqqdtldadihietenQGMYKFMSSQHLFKLLDCLQESHSFSKAFNSNYE 1640
Cdd:pfam20252    1 VVQLLLIQTVNEIL--------------------------------DEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLE 48

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   1641 QRTVLWRAGFkGKSKPNLLKQETSSLACCLRILFRMYVDENRR-DSWGEIQQRLLTVCSEALAYFITVN-SESHRE--AW 1716
Cdd:pfam20252   49 LRTALWRAGF-MKQLPNLLKQETSSLSTYLRILFRLYADDEPRtSQREEVEERLIPLCEDILEYYLSLDeEEKQRElaAW 127

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 31342051   1717 TSLLLLLLTKTLKINDEKFKAHASVYYPYLCEMMQFDLIPELRAVLRKFFL 1767
Cdd:pfam20252  128 TPVVVLILQGLLALPDDDFRRHLPEFYPLLCDLILCELSPEVRLALREFFS 178
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 377-532 7.37e-53

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 182.69  E-value: 7.37e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051    377 LQKDAFLVFRSLCKLS-MKPLGEgpPDPKSHELRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSV 455
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSnGKPLSK--SDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSS 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31342051    456 PDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILEtSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLN 532
Cdd:pfam12783   79 FPVFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLE-SDSSLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 28-197 6.36e-41

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 148.94  E-value: 6.36e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051     28 QHSQLRRACQVALDEIKAELEKQ-------------RL---GAAAPPKANFIEA-DKYFLPFELACQSKSPRVVSTSLDC 90
Cdd:pfam16213    1 QGSKLLEALQSDLRTLSSEAKRKyppvkeasekgilRLrtvHSSSPLMQNLLSAsEDILKPFVLACETKNPKLVQIALGC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051     91 LQKLIAYGHITGNApdsgapgkrlIDRIVETVCNCFQGPQTdegVQLQIIKALLTAVTSPHIeIHEGTILQTVRTCYNIY 170
Cdd:pfam16213   81 LQKLISHDAISQSA----------APYILDTLWMLMELGSE---IELKVLQTVLLLITTNSV-IHGDTLAKALVLCFRLH 146

                          170       180
                   ....*....|....*....|....*..
gi 31342051    171 LaSKNLINQTTAKATLTQMLNVIFTRM 197
Cdd:pfam16213  147 F-SKDPTVQNTASATLRQLVSVVFERV 172
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1174-1255 1.60e-37

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 136.08  E-value: 1.60e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31342051   1174 KFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQ 1253
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ..
gi 31342051   1254 TT 1255
Cdd:pfam09324   81 IL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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