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Conserved domains on  [gi|28212262|ref|NP_783188|]
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synembryn-B [Rattus norvegicus]

Protein Classification

synembryn( domain architecture ID 10562755)

synembryn is a guanine nucleotide exchange factor (GEF) which promotes exchange of bound GDP for free GTP, similar to human synembryn-A (also known as Ric-8A) and synembryn-B (also known as Ric-8B)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 66-483 3.07e-129

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


:

Pssm-ID: 462973  Cd Length: 412  Bit Score: 382.31  E-value: 3.07e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262    66 CLEVLRILSRDKKILAPVTTEENMQILLRLAKLHESDDSLEkvsefpVIVESLKCLCNIVFNSQVAQQ--LSLELNLAAK 143
Cdd:pfam10165   1 ALETLKILGRDPRGADPIFTKEGISTLLKLGLAFDSAGSSE------VSREALRCLANALLLSPEARQifVDRLLGYADK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262   144 LCNLLrkCKDRKFINDIKCFDLRLLFVLSLLHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEYESaidhSGPPLSPQE 223
Cdd:pfam10165  75 ACEKL--KLDKSQSSDDEFLDSRILFLLTALRTDIRLQLKKLIEGHSLLAEAIEQILARHAKRYPDS----SASSLSPME 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262   224 TDCAIEALKALFNVTVDSWKvhKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVlicplthe 303
Cdd:pfam10165 149 DMALTETLKLLFNLTLFYPD--LVPDSAFSPALPPILRLLLLLPIPSPDPLEPPLSHLINALLNLPLTDSKK-------- 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262   304 etaqeaatldelpgdktaekdtalkssamvYNGMNMEAIHVLLSFMEKRIDKGSSYREGLTPVLSLLTECSRAHRNIRKF 383
Cdd:pfam10165 219 ------------------------------YEGNNMDVVERLLDLLDKRLDAYDELDELLTPLLTLLTRLYEAAREVRKY 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262   384 LKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDL-GVKQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGR 462
Cdd:pfam10165 269 LRAKLLPPLKDRKKRLEKGDTLRGRLLRLMTSPLTpRLKDAAAELLFVLCKEDASRFVKYVGYGNAAGFLANRGLLGPGN 348

                         410       420
                  ....*....|....*....|.
gi 28212262   463 GDNWYSEDEDTDTEEYKNAKP 483
Cdd:pfam10165 349 AGEAYSSSEDSDTEEYKSAKR 369
 
Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 66-483 3.07e-129

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


Pssm-ID: 462973  Cd Length: 412  Bit Score: 382.31  E-value: 3.07e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262    66 CLEVLRILSRDKKILAPVTTEENMQILLRLAKLHESDDSLEkvsefpVIVESLKCLCNIVFNSQVAQQ--LSLELNLAAK 143
Cdd:pfam10165   1 ALETLKILGRDPRGADPIFTKEGISTLLKLGLAFDSAGSSE------VSREALRCLANALLLSPEARQifVDRLLGYADK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262   144 LCNLLrkCKDRKFINDIKCFDLRLLFVLSLLHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEYESaidhSGPPLSPQE 223
Cdd:pfam10165  75 ACEKL--KLDKSQSSDDEFLDSRILFLLTALRTDIRLQLKKLIEGHSLLAEAIEQILARHAKRYPDS----SASSLSPME 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262   224 TDCAIEALKALFNVTVDSWKvhKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVlicplthe 303
Cdd:pfam10165 149 DMALTETLKLLFNLTLFYPD--LVPDSAFSPALPPILRLLLLLPIPSPDPLEPPLSHLINALLNLPLTDSKK-------- 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262   304 etaqeaatldelpgdktaekdtalkssamvYNGMNMEAIHVLLSFMEKRIDKGSSYREGLTPVLSLLTECSRAHRNIRKF 383
Cdd:pfam10165 219 ------------------------------YEGNNMDVVERLLDLLDKRLDAYDELDELLTPLLTLLTRLYEAAREVRKY 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262   384 LKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDL-GVKQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGR 462
Cdd:pfam10165 269 LRAKLLPPLKDRKKRLEKGDTLRGRLLRLMTSPLTpRLKDAAAELLFVLCKEDASRFVKYVGYGNAAGFLANRGLLGPGN 348

                         410       420
                  ....*....|....*....|.
gi 28212262   463 GDNWYSEDEDTDTEEYKNAKP 483
Cdd:pfam10165 349 AGEAYSSSEDSDTEEYKSAKR 369
 
Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 66-483 3.07e-129

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


Pssm-ID: 462973  Cd Length: 412  Bit Score: 382.31  E-value: 3.07e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262    66 CLEVLRILSRDKKILAPVTTEENMQILLRLAKLHESDDSLEkvsefpVIVESLKCLCNIVFNSQVAQQ--LSLELNLAAK 143
Cdd:pfam10165   1 ALETLKILGRDPRGADPIFTKEGISTLLKLGLAFDSAGSSE------VSREALRCLANALLLSPEARQifVDRLLGYADK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262   144 LCNLLrkCKDRKFINDIKCFDLRLLFVLSLLHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEYESaidhSGPPLSPQE 223
Cdd:pfam10165  75 ACEKL--KLDKSQSSDDEFLDSRILFLLTALRTDIRLQLKKLIEGHSLLAEAIEQILARHAKRYPDS----SASSLSPME 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262   224 TDCAIEALKALFNVTVDSWKvhKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVlicplthe 303
Cdd:pfam10165 149 DMALTETLKLLFNLTLFYPD--LVPDSAFSPALPPILRLLLLLPIPSPDPLEPPLSHLINALLNLPLTDSKK-------- 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262   304 etaqeaatldelpgdktaekdtalkssamvYNGMNMEAIHVLLSFMEKRIDKGSSYREGLTPVLSLLTECSRAHRNIRKF 383
Cdd:pfam10165 219 ------------------------------YEGNNMDVVERLLDLLDKRLDAYDELDELLTPLLTLLTRLYEAAREVRKY 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28212262   384 LKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDL-GVKQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGR 462
Cdd:pfam10165 269 LRAKLLPPLKDRKKRLEKGDTLRGRLLRLMTSPLTpRLKDAAAELLFVLCKEDASRFVKYVGYGNAAGFLANRGLLGPGN 348

                         410       420
                  ....*....|....*....|.
gi 28212262   463 GDNWYSEDEDTDTEEYKNAKP 483
Cdd:pfam10165 349 AGEAYSSSEDSDTEEYKSAKR 369
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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