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Conserved domains on  [gi|30172570|ref|NP_780432|]
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axonemal dynein light intermediate polypeptide 1 [Mus musculus]

Protein Classification

dynein arm light chain( domain architecture ID 11185876)

axonemal dynein arm light chain plays a dynamic role in flagellar and cilia motility

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ax_dynein_light pfam10211
Axonemal dynein light chain; Axonemal dynein light chain proteins play a dynamic role in ...
 66-252 4.26e-118

Axonemal dynein light chain; Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organizms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.


:

Pssm-ID: 463000 [Multi-domain]  Cd Length: 187  Bit Score: 335.31  E-value: 4.26e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172570    66 EEILNAILPPREWVEDTQLWIQQVSSTPSTRMDVVHLQEQLDLKLQQRQARETGICPVRRELYSQCFDELIREVTINCAE 145
Cdd:pfam10211   1 EDILNSILPPREWEEDGQLWIQQVSSTPATRLDVINLQEKLDTRLQQRQARETGICPIREELYSQCFDELIRQVTINCPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172570   146 RGLLLLRVRDEIHMTIAAYQTLYESSVAFGMRKALQAEQGKSDMERKITELETEKRDLERQVNEQKAKCEATEKRESERR 225
Cdd:pfam10211  81 RGLLLLRVRDELRMTIAAYQTLYESSVAFGMRKALQAEQGKAELEKKIADLEEEKEELEKQVAELKAKCEAIEKREEERR 160

                         170       180
                  ....*....|....*....|....*..
gi 30172570   226 QVEEKKHNEEIQFLKRTNQQLKAQLEG 252
Cdd:pfam10211 161 QAEEKKHAEEIAFLKKTNQQLKAQLER 187
 
Name Accession Description Interval E-value
Ax_dynein_light pfam10211
Axonemal dynein light chain; Axonemal dynein light chain proteins play a dynamic role in ...
 66-252 4.26e-118

Axonemal dynein light chain; Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organizms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.


Pssm-ID: 463000 [Multi-domain]  Cd Length: 187  Bit Score: 335.31  E-value: 4.26e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172570    66 EEILNAILPPREWVEDTQLWIQQVSSTPSTRMDVVHLQEQLDLKLQQRQARETGICPVRRELYSQCFDELIREVTINCAE 145
Cdd:pfam10211   1 EDILNSILPPREWEEDGQLWIQQVSSTPATRLDVINLQEKLDTRLQQRQARETGICPIREELYSQCFDELIRQVTINCPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172570   146 RGLLLLRVRDEIHMTIAAYQTLYESSVAFGMRKALQAEQGKSDMERKITELETEKRDLERQVNEQKAKCEATEKRESERR 225
Cdd:pfam10211  81 RGLLLLRVRDELRMTIAAYQTLYESSVAFGMRKALQAEQGKAELEKKIADLEEEKEELEKQVAELKAKCEAIEKREEERR 160

                         170       180
                  ....*....|....*....|....*..
gi 30172570   226 QVEEKKHNEEIQFLKRTNQQLKAQLEG 252
Cdd:pfam10211 161 QAEEKKHAEEIAFLKKTNQQLKAQLER 187
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
187-251 1.36e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 42.92  E-value: 1.36e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30172570 187 SDMERKITELETEKRDLERQVNEQKAKCEATEKRESERRQVEEKKH--NEEIQFLKRTNQQLKAQLE 251
Cdd:COG2433 416 RRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEERREIrkDREISRLDREIERLERELE 482
PTZ00121 PTZ00121
MAEBL; Provisional
 169-251 5.15e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.20  E-value: 5.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172570   169 ESSVAFGMRKALQAEQGKSDMERKITELETEKRDLERQVNEQKAKCEATEKRESERRQVEEKKHNEEIQFLKRTNQQLKA 248
Cdd:PTZ00121 1596 EVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKK 1675


                  ...
gi 30172570   249 QLE 251
Cdd:PTZ00121 1676 KAE 1678
 
Name Accession Description Interval E-value
Ax_dynein_light pfam10211
Axonemal dynein light chain; Axonemal dynein light chain proteins play a dynamic role in ...
 66-252 4.26e-118

Axonemal dynein light chain; Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organizms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.


Pssm-ID: 463000 [Multi-domain]  Cd Length: 187  Bit Score: 335.31  E-value: 4.26e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172570    66 EEILNAILPPREWVEDTQLWIQQVSSTPSTRMDVVHLQEQLDLKLQQRQARETGICPVRRELYSQCFDELIREVTINCAE 145
Cdd:pfam10211   1 EDILNSILPPREWEEDGQLWIQQVSSTPATRLDVINLQEKLDTRLQQRQARETGICPIREELYSQCFDELIRQVTINCPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172570   146 RGLLLLRVRDEIHMTIAAYQTLYESSVAFGMRKALQAEQGKSDMERKITELETEKRDLERQVNEQKAKCEATEKRESERR 225
Cdd:pfam10211  81 RGLLLLRVRDELRMTIAAYQTLYESSVAFGMRKALQAEQGKAELEKKIADLEEEKEELEKQVAELKAKCEAIEKREEERR 160

                         170       180
                  ....*....|....*....|....*..
gi 30172570   226 QVEEKKHNEEIQFLKRTNQQLKAQLEG 252
Cdd:pfam10211 161 QAEEKKHAEEIAFLKKTNQQLKAQLER 187
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
187-251 1.36e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 42.92  E-value: 1.36e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30172570 187 SDMERKITELETEKRDLERQVNEQKAKCEATEKRESERRQVEEKKH--NEEIQFLKRTNQQLKAQLE 251
Cdd:COG2433 416 RRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEERREIrkDREISRLDREIERLERELE 482
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 178-255 3.84e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.21  E-value: 3.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172570 178 KALQAEQgkSDMERKITELETEKRDLERQVNEQKAKCEATEKRESERRQV------EEKKHNEEIQFLKRTNQQLKAQLE 251
Cdd:COG4942 153 EELRADL--AELAALRAELEAERAELEALLAELEEERAALEALKAERQKLlarlekELAELAAELAELQQEAEELEALIA 230


                ....
gi 30172570 252 GIIA 255
Cdd:COG4942 231 RLEA 234
PTZ00121 PTZ00121
MAEBL; Provisional
 169-251 5.15e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.20  E-value: 5.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172570   169 ESSVAFGMRKALQAEQGKSDMERKITELETEKRDLERQVNEQKAKCEATEKRESERRQVEEKKHNEEIQFLKRTNQQLKA 248
Cdd:PTZ00121 1596 EVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKK 1675


                  ...
gi 30172570   249 QLE 251
Cdd:PTZ00121 1676 KAE 1678
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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