|
Name |
Accession |
Description |
Interval |
E-value |
| LPLAT_DHAPAT-like |
cd07993 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ... |
139-350 |
9.38e-91 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.
Pssm-ID: 153255 [Multi-domain] Cd Length: 205 Bit Score: 282.92 E-value: 9.38e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 139 LSGVVTNTKQIEMLKTATERspGTPLIFVPLHRSHLDYIMVTWILTNNDIRSPLVAAGNNLQIPVFGGLLRGLGAFFIKR 218
Cdd:cd07993 1 FDGVQVNEGQLERLRKAAQE--GHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIPILGTLLRRLGAFFIRR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 219 KIDpvegkKDVLYRAALHLYLTHALKQGHNVEFFIEGGRTRTGKPCMPKGGILSVIVNAFMDGSIPDALLVPVSVNYERL 298
Cdd:cd07993 79 SFG-----KDPLYRAVLQEYVQELLKNGQPLEFFIEGTRSRTGKLLPPKLGLLSVVVEAYLKGSVPDVLIVPVSISYDRV 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 24650754 299 VDGNFVREQKGEKKIPESFGKAISGIWKALKSNYGLMRIDFNEPYSIRELVN 350
Cdd:cd07993 154 LEEELYAEELLGPPKPKESLSGLLGASKILRENFGRIRVDFGEPISLREYLG 205
|
|
| PlsB |
COG2937 |
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ... |
92-565 |
1.14e-68 |
|
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Pssm-ID: 442180 [Multi-domain] Cd Length: 707 Bit Score: 239.83 E-value: 1.14e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 92 KRGISyqaiLRKQEQRAISILKDMGSTLNNGLLAFTSWILYKLLPCFLSGVVTNtkQIEMLKTAterSPGTPLIFVPLHR 171
Cdd:COG2937 142 SKGIS----EEKARKEARRYLREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD--NLERLREL---AKGHEIVYVPCHR 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 172 SHLDYIMVTWILTNNDIRSPLVAAGNNLQIPVFGGLLRGLGAFFIKRKIdpvegKKDVLYRAALHLYLTHALKQGHNVEF 251
Cdd:COG2937 213 SHMDYLLLSYVLYHNGLVPPHIAAGINLNFWPLGPILRRGGAFFIRRSF-----KGNKLYSAVFREYLAELFERGYSVEY 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 252 FIEGGRTRTGKPCMPKGGILSVIVNAFMDGSIPDALLVPVSVNYERLV-DGNFVREQKGEKKIPESFGKAISGIwKALKS 330
Cdd:COG2937 288 FIEGGRSRTGRLLPPKTGMLSMTVQAFLRGARRPVVFVPVYIGYERVLeVGSYAKELRGGEKKKESLGGLLRAL-RKLRR 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 331 NYGLMRIDFNEPYSIRELVNSYNKIAREDGNIakvyKPsarvlqhnqstsslygtdvvcEEHRNLIESISRQVVFDCAAA 410
Cdd:COG2937 367 RFGRVYVNFGEPISLSEYLDQHVPDWRESEDL----RP---------------------EWLRPAVDKLAFEIMVRINRA 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 411 TSVMSTNALAFLLLTRFRNGAEEQILSEALDDLrnsLSGCKDIGFSGESS-------QIVAYACDLlgsGLVTRSRDENG 483
Cdd:COG2937 422 AAVNPVNLVALALLASPKRALTEAELLAQLDLY---LDLLRNVPYSLSVTlpeltpeELLEHLLSL---GLIEVEKDGLG 495
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 484 RLVIkaVNSvESFIELAYYSNMLTPHFALSSILLTTFHsllpetenkKEAAVSRKKLIDTALencQIYRY---EFILNKP 560
Cdd:COG2937 496 DVIS--IDD-EQAVLLTYYRNNILHLFALPALIASALL---------ANRRISRAELLELVR---LLYPLlkaELFLRWD 560
|
....*
gi 24650754 561 TQVLE 565
Cdd:COG2937 561 AEFEE 565
|
|
| PRK04974 |
PRK04974 |
glycerol-3-phosphate 1-O-acyltransferase PlsB; |
103-516 |
1.99e-39 |
|
glycerol-3-phosphate 1-O-acyltransferase PlsB;
Pssm-ID: 235325 [Multi-domain] Cd Length: 818 Bit Score: 156.54 E-value: 1.99e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 103 KQEQRAISILKDMGSTLNNGLLAFT----SWI---LYKllpcflsGV-VTNTKQIEMLKtaterSPGTPLIFVPLHRSHL 174
Cdd:PRK04974 247 KARQNAIAYMDEIAADYSYSAIRLAdrflTWLwnrLYQ-------GInVHNAERVRQLA-----QDGHEIVYVPCHRSHM 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 175 DYIMVTWILTNNDIRSPLVAAGNNLQIPVFGGLLRGLGAFFIKRKIdpvegKKDVLYRAALHLYLTHALKQGHNVEFFIE 254
Cdd:PRK04974 315 DYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRGGAFFIRRSF-----KGNKLYSTVFREYLGELFARGYSVEYFVE 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 255 GGRTRTGKPCMPKGGILSVIVNAFMDGSIPDALLVPVSVNYERLVDGN-FVREQKGEKKIPESFGKAISGIWKalKSNYG 333
Cdd:PRK04974 390 GGRSRTGRLLQPKTGMLAMTLQAMLRGSRRPITLVPVYIGYEHVMEVGtYAKELRGAPKEKESLFQVLRGIRK--LRNFG 467
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 334 LMRIDFNEPYSIRELVNSYNKIAREDGNIAKVYKPSarvlqhnqstsslYGTDVVceehrnliESISRQVV--FDCAAAT 411
Cdd:PRK04974 468 QGYVNFGEPIPLNDYLNQHVPEWRESIDPIEEQRPA-------------WLTPAV--------NNLANQVMvrINNAAAA 526
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 412 SVMSTNALAfLLLTRfRNGAEEQILSEALDDLRNSLsgcKDIGFSGESS-------QIVAYAcdlLGSGLVTRSRDENGR 484
Cdd:PRK04974 527 NPVNLCALA-LLASR-QRALDREQLIEQLDLYLQLL---RNVPYSSDTTvpegsgeELIDHA---LSLNKFEVEKDTLGD 598
|
410 420 430
....*....|....*....|....*....|..
gi 24650754 485 LVIKAVNSVesfIELAYYSNMLTPHFALSSIL 516
Cdd:PRK04974 599 IISLDREQA---VLMTYYRNNILHLFVLPSLI 627
|
|
| PlsC |
smart00563 |
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ... |
164-295 |
1.83e-25 |
|
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.
Pssm-ID: 214724 [Multi-domain] Cd Length: 118 Bit Score: 101.66 E-value: 1.83e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 164 LIFVPLHRSHLDYIMVTWILTNNDIRSPLVAAGNNLQIPVFGGLLRGLGAFFIKRkidpvegKKDVLYRAALHLYLtHAL 243
Cdd:smart00563 1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDR-------SNGRKARAALREAV-ELL 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 24650754 244 KQGHNVEFFIEGGRTRTGKPCMPKGGILSVIVNAfmdgsipDALLVPVSVNY 295
Cdd:smart00563 73 KEGEWLLIFPEGTRSRPGKLLPFKKGAARLALEA-------GVPIVPVAIRG 117
|
|
| Acyltransferase |
pfam01553 |
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ... |
160-293 |
4.34e-20 |
|
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.
Pssm-ID: 366704 [Multi-domain] Cd Length: 131 Bit Score: 86.95 E-value: 4.34e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 160 PGTPLIFVPLHRSHLDYIMVTWILTNNDIRSPLVAAGNNLQIPVFGGLLRGLGAFFIKRkidpvegkKDVLYRAALHLYL 239
Cdd:pfam01553 12 RGGPAIVVANHQSYLDVLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDR--------KNRKDAAGTLEYL 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 24650754 240 THALKQGHNVEFFIEGGRTRTGKPCMPKGGILSVIVNAfmdgsipDALLVPVSV 293
Cdd:pfam01553 84 VELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEA-------GVPIVPVAI 130
|
|
| PlsC |
COG0204 |
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ... |
160-322 |
5.59e-14 |
|
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Pssm-ID: 439974 [Multi-domain] Cd Length: 215 Bit Score: 71.58 E-value: 5.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 160 PGTPLIFVPLHRSHLDyIMVTWILTNNDIRspLVAAGNNLQIPVFGGLLRGLGAFFIKRKidpvEGKKDvlyRAALHlYL 239
Cdd:COG0204 41 ADGPVLIVANHQSWLD-ILLLLAALPRPVR--FVAKKELFKIPLLGWLLRALGAIPVDRS----KRRAA---LRALR-QA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 240 THALKQGHNVEFFIEGGRTRTGKPCMPKGGILSVIVNAfmdgsipDALLVPVSVNYERLVDGNFVREQKGEKKIpeSFGK 319
Cdd:COG0204 110 VEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEA-------GVPIVPVAIDGTERALPKGFLPRPGKVTV--RIGP 180
|
...
gi 24650754 320 AIS 322
Cdd:COG0204 181 PID 183
|
|
| GPAT_C |
pfam19277 |
Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal ... |
304-566 |
1.67e-06 |
|
Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal region of Glycerol-3-phosphate acyltransferase.
Pssm-ID: 466024 Cd Length: 370 Bit Score: 50.98 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 304 VREQKGEKKIPESFGKAISGIWKALKSNYGLMRIDFNEPYSIRELvnsynkIAREDGNIAkvykpsarvlqhnqstssly 383
Cdd:pfam19277 2 AAELLGGPKKPEGLSWLLSYARSQLSLKLGRVYVRFGEPWSLREF------LDEQGDRPA-------------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 384 gtdVVCEEHRNLIESISRQVVFDCAAATSVMSTNALAFLLLT-RFRN-GAEEqiLSEALDDLRNSLSGcKDI---GFSG- 457
Cdd:pfam19277 56 ---TDAARRRLALQKLAFEVLSRINRVTPVMPTALVGTVLLTlRGRAlTLSE--LIRRVEWLLDYIRA-RGGpvaHFGDl 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 458 ESSQIVAYACDLLG-SGLVTRSRDenGRLVIKAVNSVESFiELAYYSNMLTPHFALSSI----LLTTFHSLlpetenkkE 532
Cdd:pfam19277 130 RTEEVVDRALDVLGnAGLVTRVDG--GPEPVYYIAPEDHF-QASFYRNMTIHLFVERAIvelaLLTKVKAA--------Q 198
|
250 260 270
....*....|....*....|....*....|....
gi 24650754 533 AAVSRKKLIDTALENCQIYRYEFILNKPTQVLEN 566
Cdd:pfam19277 199 RGDSYEALWDQVLRLRDLLKFEFFFPPKEGFREN 232
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LPLAT_DHAPAT-like |
cd07993 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ... |
139-350 |
9.38e-91 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.
Pssm-ID: 153255 [Multi-domain] Cd Length: 205 Bit Score: 282.92 E-value: 9.38e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 139 LSGVVTNTKQIEMLKTATERspGTPLIFVPLHRSHLDYIMVTWILTNNDIRSPLVAAGNNLQIPVFGGLLRGLGAFFIKR 218
Cdd:cd07993 1 FDGVQVNEGQLERLRKAAQE--GHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIPILGTLLRRLGAFFIRR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 219 KIDpvegkKDVLYRAALHLYLTHALKQGHNVEFFIEGGRTRTGKPCMPKGGILSVIVNAFMDGSIPDALLVPVSVNYERL 298
Cdd:cd07993 79 SFG-----KDPLYRAVLQEYVQELLKNGQPLEFFIEGTRSRTGKLLPPKLGLLSVVVEAYLKGSVPDVLIVPVSISYDRV 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 24650754 299 VDGNFVREQKGEKKIPESFGKAISGIWKALKSNYGLMRIDFNEPYSIRELVN 350
Cdd:cd07993 154 LEEELYAEELLGPPKPKESLSGLLGASKILRENFGRIRVDFGEPISLREYLG 205
|
|
| PlsB |
COG2937 |
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ... |
92-565 |
1.14e-68 |
|
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Pssm-ID: 442180 [Multi-domain] Cd Length: 707 Bit Score: 239.83 E-value: 1.14e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 92 KRGISyqaiLRKQEQRAISILKDMGSTLNNGLLAFTSWILYKLLPCFLSGVVTNtkQIEMLKTAterSPGTPLIFVPLHR 171
Cdd:COG2937 142 SKGIS----EEKARKEARRYLREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD--NLERLREL---AKGHEIVYVPCHR 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 172 SHLDYIMVTWILTNNDIRSPLVAAGNNLQIPVFGGLLRGLGAFFIKRKIdpvegKKDVLYRAALHLYLTHALKQGHNVEF 251
Cdd:COG2937 213 SHMDYLLLSYVLYHNGLVPPHIAAGINLNFWPLGPILRRGGAFFIRRSF-----KGNKLYSAVFREYLAELFERGYSVEY 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 252 FIEGGRTRTGKPCMPKGGILSVIVNAFMDGSIPDALLVPVSVNYERLV-DGNFVREQKGEKKIPESFGKAISGIwKALKS 330
Cdd:COG2937 288 FIEGGRSRTGRLLPPKTGMLSMTVQAFLRGARRPVVFVPVYIGYERVLeVGSYAKELRGGEKKKESLGGLLRAL-RKLRR 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 331 NYGLMRIDFNEPYSIRELVNSYNKIAREDGNIakvyKPsarvlqhnqstsslygtdvvcEEHRNLIESISRQVVFDCAAA 410
Cdd:COG2937 367 RFGRVYVNFGEPISLSEYLDQHVPDWRESEDL----RP---------------------EWLRPAVDKLAFEIMVRINRA 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 411 TSVMSTNALAFLLLTRFRNGAEEQILSEALDDLrnsLSGCKDIGFSGESS-------QIVAYACDLlgsGLVTRSRDENG 483
Cdd:COG2937 422 AAVNPVNLVALALLASPKRALTEAELLAQLDLY---LDLLRNVPYSLSVTlpeltpeELLEHLLSL---GLIEVEKDGLG 495
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 484 RLVIkaVNSvESFIELAYYSNMLTPHFALSSILLTTFHsllpetenkKEAAVSRKKLIDTALencQIYRY---EFILNKP 560
Cdd:COG2937 496 DVIS--IDD-EQAVLLTYYRNNILHLFALPALIASALL---------ANRRISRAELLELVR---LLYPLlkaELFLRWD 560
|
....*
gi 24650754 561 TQVLE 565
Cdd:COG2937 561 AEFEE 565
|
|
| PRK04974 |
PRK04974 |
glycerol-3-phosphate 1-O-acyltransferase PlsB; |
103-516 |
1.99e-39 |
|
glycerol-3-phosphate 1-O-acyltransferase PlsB;
Pssm-ID: 235325 [Multi-domain] Cd Length: 818 Bit Score: 156.54 E-value: 1.99e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 103 KQEQRAISILKDMGSTLNNGLLAFT----SWI---LYKllpcflsGV-VTNTKQIEMLKtaterSPGTPLIFVPLHRSHL 174
Cdd:PRK04974 247 KARQNAIAYMDEIAADYSYSAIRLAdrflTWLwnrLYQ-------GInVHNAERVRQLA-----QDGHEIVYVPCHRSHM 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 175 DYIMVTWILTNNDIRSPLVAAGNNLQIPVFGGLLRGLGAFFIKRKIdpvegKKDVLYRAALHLYLTHALKQGHNVEFFIE 254
Cdd:PRK04974 315 DYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRGGAFFIRRSF-----KGNKLYSTVFREYLGELFARGYSVEYFVE 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 255 GGRTRTGKPCMPKGGILSVIVNAFMDGSIPDALLVPVSVNYERLVDGN-FVREQKGEKKIPESFGKAISGIWKalKSNYG 333
Cdd:PRK04974 390 GGRSRTGRLLQPKTGMLAMTLQAMLRGSRRPITLVPVYIGYEHVMEVGtYAKELRGAPKEKESLFQVLRGIRK--LRNFG 467
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 334 LMRIDFNEPYSIRELVNSYNKIAREDGNIAKVYKPSarvlqhnqstsslYGTDVVceehrnliESISRQVV--FDCAAAT 411
Cdd:PRK04974 468 QGYVNFGEPIPLNDYLNQHVPEWRESIDPIEEQRPA-------------WLTPAV--------NNLANQVMvrINNAAAA 526
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 412 SVMSTNALAfLLLTRfRNGAEEQILSEALDDLRNSLsgcKDIGFSGESS-------QIVAYAcdlLGSGLVTRSRDENGR 484
Cdd:PRK04974 527 NPVNLCALA-LLASR-QRALDREQLIEQLDLYLQLL---RNVPYSSDTTvpegsgeELIDHA---LSLNKFEVEKDTLGD 598
|
410 420 430
....*....|....*....|....*....|..
gi 24650754 485 LVIKAVNSVesfIELAYYSNMLTPHFALSSIL 516
Cdd:PRK04974 599 IISLDREQA---VLMTYYRNNILHLFVLPSLI 627
|
|
| PRK03355 |
PRK03355 |
glycerol-3-phosphate 1-O-acyltransferase; |
144-515 |
3.90e-36 |
|
glycerol-3-phosphate 1-O-acyltransferase;
Pssm-ID: 179567 [Multi-domain] Cd Length: 783 Bit Score: 146.01 E-value: 3.90e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 144 TNTKQIEMLKTATERspgTPLIFVPLHRSHLDYIMVTWILTNNDIRSPLVAAGNNLQIPVFGGLLRGLGAFFIKRKI--D 221
Cdd:PRK03355 252 YDEYELAALRALLEE---HPAVLLFSHRSYIDGLVVPVAMQENRLPPVHVFGGINLSFGPMGPIMRRSGMIFIRRNIgdD 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 222 PVegkkdvlYRAALHLYLTHALKQGHNVEFFIEGGRTRTGKPCMPKGGILSVIVNAFMDGSIPDALLVPVSVNYERLVD- 300
Cdd:PRK03355 329 PL-------YKYVLREYVGYLVEKRFNLSWYIEGTRSRTGKLLPPKLGLLSYVADAYLDGRSDDVLLQPVSISFDQLHEi 401
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 301 GNFVREQKGEKKIPESFGKAISGIWKALKSNYGLMRIDFNEPYSIRElvnsynKIAREDGNIAKvyKPSARVLQhnqsts 380
Cdd:PRK03355 402 GEYAAEARGGEKTPEGLRWLYNYIKAQGERNYGKIYVRFGEPVSMRQ------YLGAPHGPLTQ--DPDAKRLA------ 467
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 381 slygtdvvceehrnlIESISRQVVFDCAAATSVMSTNALAFLLL-TRFRNGAEEQ---ILSEALDDLRNslsgcKDIGFS 456
Cdd:PRK03355 468 ---------------LQKMAFEVAWRINQVTPVTATSLVSLLLLgTRGRALTLDElhhTLQDSLDYLER-----RQLPVS 527
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24650754 457 GE-----SSQIVAYACD-LLGSGLVTRSrdENGRlviKAVNSVESFIEL--AYYSNMLTPHFALSSI 515
Cdd:PRK03355 528 TSalrlrDPEGVRAALDaLSNGGPVTRV--DSGR---EPVWYIAPDDHLvaAFYRNSVIHAFLERAI 589
|
|
| PTZ00374 |
PTZ00374 |
dihydroxyacetone phosphate acyltransferase; Provisional |
92-348 |
4.26e-33 |
|
dihydroxyacetone phosphate acyltransferase; Provisional
Pssm-ID: 240389 [Multi-domain] Cd Length: 1108 Bit Score: 137.32 E-value: 4.26e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 92 KRGISYQAILRkqeqRAISILKDMGSTLNNGLLAFTSWILYKLLPCFLSGVVTNTKQIEMLKTATErSPGTPLIFVPLHR 171
Cdd:PTZ00374 564 KEGASEKDVEA----RAKAILRTCGDNLNHVQCRLFGLMVRRILFRLYDRVSLNSGAFERLHRYVA-MPRVAVVLLPLHR 638
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 172 SHLDYIMVTWILTNNDIRSPLVAAGNN-LQIPVFGGLLRGLGAFFIKRKIdpvegKKDVLYRAALHLYLTHALKQGHNVE 250
Cdd:PTZ00374 639 SYIDFIIMTYLLAVMGLPLPHVCAGDDfLRMGPIATLMRGSGAFFMRRSF-----RDDPLYAALFKEYVRHLVLRRRPLE 713
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 251 FFIEGGRTRTGKPCMPKGGILSVIVNAFMDG--SIPDALLVPVSVNYERLVDGN-FVREQKGEKKIPESFG---KAISgi 324
Cdd:PTZ00374 714 FFIEGTRSRTGKTMAPKLGLLKFICDTFYEGqqELDDVLIIPVSLSYDELLETTlYAKEQLGVSKPKENPGnllRARS-- 791
|
250 260
....*....|....*....|....
gi 24650754 325 wkALKSNYGLMRIDFNEPYSIREL 348
Cdd:PTZ00374 792 --LLKRRHGKIHVHIGEPVSLRSF 813
|
|
| PlsC |
smart00563 |
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ... |
164-295 |
1.83e-25 |
|
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.
Pssm-ID: 214724 [Multi-domain] Cd Length: 118 Bit Score: 101.66 E-value: 1.83e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 164 LIFVPLHRSHLDYIMVTWILTNNDIRSPLVAAGNNLQIPVFGGLLRGLGAFFIKRkidpvegKKDVLYRAALHLYLtHAL 243
Cdd:smart00563 1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDR-------SNGRKARAALREAV-ELL 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 24650754 244 KQGHNVEFFIEGGRTRTGKPCMPKGGILSVIVNAfmdgsipDALLVPVSVNY 295
Cdd:smart00563 73 KEGEWLLIFPEGTRSRPGKLLPFKKGAARLALEA-------GVPIVPVAIRG 117
|
|
| Acyltransferase |
pfam01553 |
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ... |
160-293 |
4.34e-20 |
|
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.
Pssm-ID: 366704 [Multi-domain] Cd Length: 131 Bit Score: 86.95 E-value: 4.34e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 160 PGTPLIFVPLHRSHLDYIMVTWILTNNDIRSPLVAAGNNLQIPVFGGLLRGLGAFFIKRkidpvegkKDVLYRAALHLYL 239
Cdd:pfam01553 12 RGGPAIVVANHQSYLDVLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDR--------KNRKDAAGTLEYL 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 24650754 240 THALKQGHNVEFFIEGGRTRTGKPCMPKGGILSVIVNAfmdgsipDALLVPVSV 293
Cdd:pfam01553 84 VELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEA-------GVPIVPVAI 130
|
|
| PRK11915 |
PRK11915 |
lysophospholipid acyltransferase; |
108-347 |
1.83e-19 |
|
lysophospholipid acyltransferase;
Pssm-ID: 237022 [Multi-domain] Cd Length: 621 Bit Score: 93.08 E-value: 1.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 108 AISILKDMGSTLN----NGLLAFTSWILYKLlpcflsGVVTNTKQIEMLKTATERSPgtpLIFVPLHRSHLDYIMVTWIL 183
Cdd:PRK11915 66 AAGYLREMAASLDeravQAWRGFSRWLMRAY------DVLVDEDQITQLRKLDRKAT---LAFAFSHRSYLDGMLLPEVI 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 184 TNNDIRSPLVAAGNNLQIPVFGGLLRGLGAFFIKRKIdpvegkKDV-LYRAALHLYLTHALKQGHNVEFFIEGGRTRTGK 262
Cdd:PRK11915 137 LANRLSPALTFGGANLNFFPMGAWAKRTGAIFIRRQT------KDIpVYRFVLRAYAAQLVQNHVNLTWSIEGGRTRTGK 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 263 PCMPKGGILSVIVNAFMDGSIPDALLVPVSVNYERLVDGN-FVREQKGEKKIPESFgKAISGIWKALKSNYGLMRIDFNE 341
Cdd:PRK11915 211 LRPPVFGILRYITDAVDEIDGPEVYLVPTSIVYDQLHEVEaMTTEAYGAVKRPEDL-RFLVRLARQQGERLGRAYLDFGE 289
|
....*.
gi 24650754 342 PYSIRE 347
Cdd:PRK11915 290 PLPLRK 295
|
|
| PlsC |
COG0204 |
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ... |
160-322 |
5.59e-14 |
|
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Pssm-ID: 439974 [Multi-domain] Cd Length: 215 Bit Score: 71.58 E-value: 5.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 160 PGTPLIFVPLHRSHLDyIMVTWILTNNDIRspLVAAGNNLQIPVFGGLLRGLGAFFIKRKidpvEGKKDvlyRAALHlYL 239
Cdd:COG0204 41 ADGPVLIVANHQSWLD-ILLLLAALPRPVR--FVAKKELFKIPLLGWLLRALGAIPVDRS----KRRAA---LRALR-QA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 240 THALKQGHNVEFFIEGGRTRTGKPCMPKGGILSVIVNAfmdgsipDALLVPVSVNYERLVDGNFVREQKGEKKIpeSFGK 319
Cdd:COG0204 110 VEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEA-------GVPIVPVAIDGTERALPKGFLPRPGKVTV--RIGP 180
|
...
gi 24650754 320 AIS 322
Cdd:COG0204 181 PID 183
|
|
| LPLAT_AGPAT-like |
cd07989 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ... |
160-295 |
1.63e-13 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.
Pssm-ID: 153251 [Multi-domain] Cd Length: 184 Bit Score: 69.61 E-value: 1.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 160 PGTPLIFVPLHRSHLDyIMVTWILTNNDIRSplVAAGNNLQIPVFGGLLRGLGAFFIKRkidpvegKKDVLYRAALHlYL 239
Cdd:cd07989 22 PKGPVIIVANHQSYLD-PLVLGAALPRPIRF--VAKKELFKIPFLGWLLRLLGAIPIDR-------GNGRSAREALR-EA 90
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 24650754 240 THALKQGHNVEFFIEGGRTRTGKPCMPKGGILSVIVNAfmdgsipDALLVPVSVNY 295
Cdd:cd07989 91 IEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEA-------GVPIVPVAISG 139
|
|
| LPLAT |
cd06551 |
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ... |
159-310 |
6.39e-07 |
|
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).
Pssm-ID: 153244 [Multi-domain] Cd Length: 187 Bit Score: 50.49 E-value: 6.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 159 SPGTPLIFVPLHRSHLDYIMVtWILTNNDIRSPLVAAGNNLQIPVFgGLLRGLGAFFIKRKiDPVEGKKDVLYRAALhly 238
Cdd:cd06551 23 PGGGPVLFVSNHSSWWDGLIL-FLLLERGLRRDVYGLMDEELLERY-PFFTRLGAFSVDRD-SPRSAAKSLKYVARL--- 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24650754 239 lthaLKQ-GHNVEFFIEGGRTRTGK-PCMPKGGILSVIVNAfmdgsipDALLVPVSVNYErlvdgNFVREQKGE 310
Cdd:cd06551 97 ----LSKpGSVVWIFPEGTRTRRDKrPLQFKPGVAHLAEKA-------GVPIVPVALRYT-----FELFEQFPE 154
|
|
| GPAT_C |
pfam19277 |
Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal ... |
304-566 |
1.67e-06 |
|
Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal region of Glycerol-3-phosphate acyltransferase.
Pssm-ID: 466024 Cd Length: 370 Bit Score: 50.98 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 304 VREQKGEKKIPESFGKAISGIWKALKSNYGLMRIDFNEPYSIRELvnsynkIAREDGNIAkvykpsarvlqhnqstssly 383
Cdd:pfam19277 2 AAELLGGPKKPEGLSWLLSYARSQLSLKLGRVYVRFGEPWSLREF------LDEQGDRPA-------------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 384 gtdVVCEEHRNLIESISRQVVFDCAAATSVMSTNALAFLLLT-RFRN-GAEEqiLSEALDDLRNSLSGcKDI---GFSG- 457
Cdd:pfam19277 56 ---TDAARRRLALQKLAFEVLSRINRVTPVMPTALVGTVLLTlRGRAlTLSE--LIRRVEWLLDYIRA-RGGpvaHFGDl 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 458 ESSQIVAYACDLLG-SGLVTRSRDenGRLVIKAVNSVESFiELAYYSNMLTPHFALSSI----LLTTFHSLlpetenkkE 532
Cdd:pfam19277 130 RTEEVVDRALDVLGnAGLVTRVDG--GPEPVYYIAPEDHF-QASFYRNMTIHLFVERAIvelaLLTKVKAA--------Q 198
|
250 260 270
....*....|....*....|....*....|....
gi 24650754 533 AAVSRKKLIDTALENCQIYRYEFILNKPTQVLEN 566
Cdd:pfam19277 199 RGDSYEALWDQVLRLRDLLKFEFFFPPKEGFREN 232
|
|
| LPLAT_AAK14816-like |
cd07992 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ... |
157-297 |
1.01e-04 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.
Pssm-ID: 153254 [Multi-domain] Cd Length: 203 Bit Score: 44.17 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650754 157 ERSP-GTPLIFVPLHR-SHLDYIMVTWILTNNdIRspLVAAGNNLQIPVFGGLLRGLGAFFIKRKIDPVEGKKDVLYRAA 234
Cdd:cd07992 22 ENVPkDGPVIFLGNHPnALIDPLLLAATLRRP-VR--FLAKADLFKNPLIGWLLESFGAIPVYRPKDLARGGIGKISNAA 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24650754 235 LHLYLTHALKQGHNVEFFIEGG---RTRTGKpcmPKGGILSVIVNAFMDGSIpDALLVPVSVNYER 297
Cdd:cd07992 99 VFDAVGEALKAGGAIGIFPEGGshdRPRLLP---LKAGAARMALEALEAGQK-DVKIVPVGLNYED 160
|
|
| |
