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Conserved domains on  [gi|532141310|ref|NP_709515|]
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PTS system arbutin-specific transporter subunit IIB [Shigella flexneri 2a str. 301]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTS-IIBC-alpha super family cl37027
PTS system, alpha-glucoside-specific IIBC component; This model represents a family of fused ...
 2-523 0e+00

PTS system, alpha-glucoside-specific IIBC component; This model represents a family of fused PTS enzyme II B and C domains. A gene from Clostridium has been partially characterized as a maltose transporter, while genes from Fusobacterium and Klebsiella have been proposed to transport the five non-standard isomers of sucrose. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


The actual alignment was detected with superfamily member TIGR02005:

Pssm-ID: 273925 [Multi-domain]  Cd Length: 524  Bit Score: 899.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310    2 LSQIQRFGGAMFTPVLLFPFAGIVVGLAILLQNPMFVGEsLTDPNSLFAQIVHIIEEGGWTVFRNMPLIFAVGLPIGLAK 81
Cdd:TIGR02005   1 MNAIQRFGGAMFVPVLLFAFAGIVVGFAILFKNPDIMGS-LADQNTFWYKFWSVIEEGGWTVFRQMPLIFVVGLPIGLAK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310   82 QAQGRACLAVMVSFLTWNYFINAMGMTWGSYFGVDFTQDA-VAGSGLTMMAGIKTLDTSIIGAIIISGIVTALHNRLFDK 160
Cdd:TIGR02005  80 KAQGRACLAALMGYLTFNYFINAILTQWGSSFGVNFTQGVgVGVSGLTSIAGIKTLDTSIIGAIIISGIITYIHNRFFDK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  161 KLPVFLGIFQGTSYVVIIAFLVMIPCAWLTLLGWPKVQMGIESLQAFLRSAGALGVWVYTFLERILIPTGLHHFIYGPFI 240
Cdd:TIGR02005 160 RLPVFLGIFQGTTFVVTIAFFVMLPCAAITCLVWPKVQMGIGSLQAFLISSGYIGVWLYTFLERILIPTGLHHFIYGPFI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  241 FGPAAVEGGIQMYWAQHLQEFSLSAEPLKSLFPEGGFALHGNSKIFGAVGISLAMYFTAAPENRVKVAGLLIPATLTAML 320
Cdd:TIGR02005 240 FGPAVVNHGIQAYWAQHLNEFAKSTKPLKELFPYGGFALHGNSKVFGCLGIALAMYATAPPENRKKVAGLLIPATLTAVV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  321 VGITEPLEFTFLFISPLLFAVHAVLAASMSTVMYLFGVVGNMGGGLIDQVLPqNWIPMFSNHADMMLTQIAIGLCFTLLY 400
Cdd:TIGR02005 320 VGITEPLEFTFLFIAPYLFVVHAVLAASMATVMYAFGVVGNMGGGLIDFIAT-NWLPLFKNHWGTYVTQIIIGLCFTAIY 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  401 FVVFRTLILQFNMCTPGREDAE--VKLYSKAEYKASRGQTT-AAEPKKELDQAAGILQALGGVGNISSINNCATRLRIAL 477
Cdd:TIGR02005 399 FLVFRFLILKFNIPTPGREDTEeeVKLYSKADYKAKKGDSVeSKRASSGNDKAAYFLQALGGKENIKDVTNCATRLRISV 478

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 532141310  478 HDMSQTLDDEVFKKLGAHGVFRSGDAIQVIIGLHVSQLREQLDSLI 523
Cdd:TIGR02005 479 KDESKVLDDEVFKKAGAHGVVRSGKAIQVIVGLSVPQVREAFEQLV 524
 
Name Accession Description Interval E-value
PTS-IIBC-alpha TIGR02005
PTS system, alpha-glucoside-specific IIBC component; This model represents a family of fused ...
 2-523 0e+00

PTS system, alpha-glucoside-specific IIBC component; This model represents a family of fused PTS enzyme II B and C domains. A gene from Clostridium has been partially characterized as a maltose transporter, while genes from Fusobacterium and Klebsiella have been proposed to transport the five non-standard isomers of sucrose. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273925 [Multi-domain]  Cd Length: 524  Bit Score: 899.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310    2 LSQIQRFGGAMFTPVLLFPFAGIVVGLAILLQNPMFVGEsLTDPNSLFAQIVHIIEEGGWTVFRNMPLIFAVGLPIGLAK 81
Cdd:TIGR02005   1 MNAIQRFGGAMFVPVLLFAFAGIVVGFAILFKNPDIMGS-LADQNTFWYKFWSVIEEGGWTVFRQMPLIFVVGLPIGLAK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310   82 QAQGRACLAVMVSFLTWNYFINAMGMTWGSYFGVDFTQDA-VAGSGLTMMAGIKTLDTSIIGAIIISGIVTALHNRLFDK 160
Cdd:TIGR02005  80 KAQGRACLAALMGYLTFNYFINAILTQWGSSFGVNFTQGVgVGVSGLTSIAGIKTLDTSIIGAIIISGIITYIHNRFFDK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  161 KLPVFLGIFQGTSYVVIIAFLVMIPCAWLTLLGWPKVQMGIESLQAFLRSAGALGVWVYTFLERILIPTGLHHFIYGPFI 240
Cdd:TIGR02005 160 RLPVFLGIFQGTTFVVTIAFFVMLPCAAITCLVWPKVQMGIGSLQAFLISSGYIGVWLYTFLERILIPTGLHHFIYGPFI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  241 FGPAAVEGGIQMYWAQHLQEFSLSAEPLKSLFPEGGFALHGNSKIFGAVGISLAMYFTAAPENRVKVAGLLIPATLTAML 320
Cdd:TIGR02005 240 FGPAVVNHGIQAYWAQHLNEFAKSTKPLKELFPYGGFALHGNSKVFGCLGIALAMYATAPPENRKKVAGLLIPATLTAVV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  321 VGITEPLEFTFLFISPLLFAVHAVLAASMSTVMYLFGVVGNMGGGLIDQVLPqNWIPMFSNHADMMLTQIAIGLCFTLLY 400
Cdd:TIGR02005 320 VGITEPLEFTFLFIAPYLFVVHAVLAASMATVMYAFGVVGNMGGGLIDFIAT-NWLPLFKNHWGTYVTQIIIGLCFTAIY 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  401 FVVFRTLILQFNMCTPGREDAE--VKLYSKAEYKASRGQTT-AAEPKKELDQAAGILQALGGVGNISSINNCATRLRIAL 477
Cdd:TIGR02005 399 FLVFRFLILKFNIPTPGREDTEeeVKLYSKADYKAKKGDSVeSKRASSGNDKAAYFLQALGGKENIKDVTNCATRLRISV 478

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 532141310  478 HDMSQTLDDEVFKKLGAHGVFRSGDAIQVIIGLHVSQLREQLDSLI 523
Cdd:TIGR02005 479 KDESKVLDDEVFKKAGAHGVVRSGKAIQVIVGLSVPQVREAFEQLV 524
PRK09702 PRK09702
PTS sugar transporter subunit IIB;
378-538 1.35e-112

PTS sugar transporter subunit IIB;


Pssm-ID: 77355 [Multi-domain]  Cd Length: 161  Bit Score: 331.29  E-value: 1.35e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 378 MFSNHADMMLTQIAIGLCFTLLYFVVFRTLILQFNMCTPGREDAEVKLYSKAEYKASRGQTTAAEPKKELDQAAGILQAL 457
Cdd:PRK09702   1 MFSNHADMMLTQIAIGLCFTLLYFVVFRTLILQFNMCTPGREDAEVKLYSKAEYKASRGQTTAAEPKKELDQAAGILQAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 458 GGVGNISSINNCATRLRIALHDMSQTLDDEVFKKLGAHGVFRSGDAIQVIIGLHVSQLREQLDSLINSHQSAENVAITEA 537
Cdd:PRK09702  81 GGVGNISSINNCATRLRIALHDMSQTLDDEVFKKLGAHGVFRSGDAIQVIIGLHVSQLREQLDSLINSHQSAENVAITEA 160


                 .
gi 532141310 538 V 538
Cdd:PRK09702 161 V 161
PtsG1 COG1263
Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific ...
 1-520 9.06e-71

Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism];


Pssm-ID: 440875 [Multi-domain]  Cd Length: 463  Bit Score: 233.68  E-value: 9.06e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310   1 MLSQIQRFGGAMFTPVLLFPFAGIVVGLAILLQNPMFVGEsltdpNSLFAQIVHIIEEGGWTVFRNMPLIFAVGLPIGLA 80
Cdd:COG1263    8 LFRFLQKIGGIFMPPIPVLPAAGLLLGLGALLTNPGLLGE-----GSFLSGTYQILNAAGDAVFYFLPLLFAIGAAKGFG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  81 kqaqGRACLAVMVSFLTWNYFINAMGMTWGSYFGVDFTQDAVAGSGlTMMAGIktldtsiigaiiISGIVTALHNRLFDK 160
Cdd:COG1263   83 ----GNPALAAVIGYLLVHPTLLNAYAVAGGYISFLGIPTLIGYQG-GVFPGI------------LAGWLAAYLEKFLKK 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 161 KLPVFLGIFqgtsYVVIIAFLVMIPCAwLTLLG--WPKVQMGI-ESLQAFLRSAGALGVWVYTFLERILIPTGLHHFIYG 237
Cdd:COG1263  146 KLPDALGFF----FVPILTLLIMVPLA-LLVIGpiWPPIGNGIaAGLGWIYGLAGAIGGFIYGFLYRLLVPTGLHHGLNP 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 238 PFIFgPAAVEGGIqmywaqhlqefslsaeplkslfpeGGFALHGnSKIFGAVGISLAMYFTAAPenRVKVAGLLIPATLT 317
Cdd:COG1263  221 IFWF-LLGGTGDD------------------------GLFPILA-AAMFGQPGAALAVYLKAKP--NKKVKGLAISAALT 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 318 AMLVGITEPLEFTFLFISPLLFAVHAVLAASMSTVMYLFGVVGNM--GGGLIDqvlpqnwIPMFSNHADMMLTQIAIGLC 395
Cdd:COG1263  273 AFLTGITEPAEFGFNLVAPKLFIAHAIGGGLGGAIAGLLGVKAFSfgVGGLID-------FPSILNPGATNLLLYLIGLV 345

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 396 FTLLYFVVFRTLIlqfnmctpGREDAEVKLYSKAEYKASRGQTTAAEPKKELDQAAGILQALGGVGNISSINNCATRLRI 475
Cdd:COG1263  346 IAFVYYFVFTFLI--------GREDEEEEEKLATKADAKKEEAEAAAAALGGGGGLLLLEADITVLLLTLVDVVIVVVKD 417

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 532141310 476 ALHDMSQTLDDEVFKKLGAHGVFRSGDAIQVIIGLHVSQLREQLD 520
Cdd:COG1263  418 VVKLAAAGAVVVGVGGVGAVGGVGGGGVVIVIVIIILVVVLEGLG 462
PTS_EIIC pfam02378
Phosphotransferase system, EIIC; The bacterial phosphoenolpyruvate: sugar phosphotransferase ...
 9-347 7.05e-51

Phosphotransferase system, EIIC; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyzes the transfer of a phosphoryl group from IIB to the sugar substrate.


Pssm-ID: 367061  Cd Length: 315  Bit Score: 176.77  E-value: 7.05e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310    9 GGAMFTPVLLFPFAGIVVGLAILLQNPMFVGESLTDPNSLFAqivHIIEEGGWTVFRNMPLIFAVGLPIGLAkQAQGRAC 88
Cdd:pfam02378   1 GDGFMPPIPLLIAGGILLGLGNLPNDTTGLPAGGFTGDSPLA---EILKQAGSAAFGILPILFAIGIAYGLA-GGDGVAG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310   89 LAVMVSFLTWNY--FINAMGMTWGsyfgvdftqdavaGSGLTMMAGIKTLDTSIIGAIIISGIVTALHNRLFD---KKLP 163
Cdd:pfam02378  77 AAGLIGLLSFNLaaAISVALTAAG-------------LSGGGNILGIGLGATGVFGAIIPGLLAAYLYNRFEKnitIKLP 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  164 VFLGIFQGTSYVVII-AFLVMIPCAWLTLLGWPKVQMGIESLQAFLRSAG-ALGVWVYTFLERILIPTGLHHFIYGPFIF 241
Cdd:pfam02378 144 DSLPFFVGKRFVPIItGFVTLLVIGPVLGLIWPAIQGGLNALGLLLIIAGgILGGLIFGFLERLLWPFGLHGAFIAIFWF 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  242 ---GPAAVEGGIQMYWAqhlqefslsaeplkslfpEGGFALHGN-SKIFGAVGISLAMYFTAAPENRVKVAGLLIPATLT 317
Cdd:pfam02378 224 lpiGGSNPIANQQAYGA------------------GAAHILTGGfDVMFGGPGATLALYAAAFLFKKSKVKKLLGSAALT 285

                         330       340       350
                  ....*....|....*....|....*....|
gi 532141310  318 AMLVGITEPLEFTFLFISPLLFAVHAVLAA 347
Cdd:pfam02378 286 PFLFGITEPLEFGFPFVLNPPFFIPAILAG 315
PTS_IIB_glc cd00212
PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: ...
 448-523 1.23e-23

PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation


Pssm-ID: 238130 [Multi-domain]  Cd Length: 78  Bit Score: 94.52  E-value: 1.23e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 532141310 448 DQAAGILQALGGVGNISSINNCATRLRIALHDMSQtLDDEVFKKL-GAHGVFRSGDAIQVIIGLHVS-QLREQLDSLI 523
Cdd:cd00212    2 QLAKDILEALGGKENIVSLDHCATRLRLTVKDESK-VDEAALKKLgGVKGVVKNGGQYQVIIGPGVAdVYKEAIKLLG 78
 
Name Accession Description Interval E-value
PTS-IIBC-alpha TIGR02005
PTS system, alpha-glucoside-specific IIBC component; This model represents a family of fused ...
 2-523 0e+00

PTS system, alpha-glucoside-specific IIBC component; This model represents a family of fused PTS enzyme II B and C domains. A gene from Clostridium has been partially characterized as a maltose transporter, while genes from Fusobacterium and Klebsiella have been proposed to transport the five non-standard isomers of sucrose. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273925 [Multi-domain]  Cd Length: 524  Bit Score: 899.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310    2 LSQIQRFGGAMFTPVLLFPFAGIVVGLAILLQNPMFVGEsLTDPNSLFAQIVHIIEEGGWTVFRNMPLIFAVGLPIGLAK 81
Cdd:TIGR02005   1 MNAIQRFGGAMFVPVLLFAFAGIVVGFAILFKNPDIMGS-LADQNTFWYKFWSVIEEGGWTVFRQMPLIFVVGLPIGLAK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310   82 QAQGRACLAVMVSFLTWNYFINAMGMTWGSYFGVDFTQDA-VAGSGLTMMAGIKTLDTSIIGAIIISGIVTALHNRLFDK 160
Cdd:TIGR02005  80 KAQGRACLAALMGYLTFNYFINAILTQWGSSFGVNFTQGVgVGVSGLTSIAGIKTLDTSIIGAIIISGIITYIHNRFFDK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  161 KLPVFLGIFQGTSYVVIIAFLVMIPCAWLTLLGWPKVQMGIESLQAFLRSAGALGVWVYTFLERILIPTGLHHFIYGPFI 240
Cdd:TIGR02005 160 RLPVFLGIFQGTTFVVTIAFFVMLPCAAITCLVWPKVQMGIGSLQAFLISSGYIGVWLYTFLERILIPTGLHHFIYGPFI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  241 FGPAAVEGGIQMYWAQHLQEFSLSAEPLKSLFPEGGFALHGNSKIFGAVGISLAMYFTAAPENRVKVAGLLIPATLTAML 320
Cdd:TIGR02005 240 FGPAVVNHGIQAYWAQHLNEFAKSTKPLKELFPYGGFALHGNSKVFGCLGIALAMYATAPPENRKKVAGLLIPATLTAVV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  321 VGITEPLEFTFLFISPLLFAVHAVLAASMSTVMYLFGVVGNMGGGLIDQVLPqNWIPMFSNHADMMLTQIAIGLCFTLLY 400
Cdd:TIGR02005 320 VGITEPLEFTFLFIAPYLFVVHAVLAASMATVMYAFGVVGNMGGGLIDFIAT-NWLPLFKNHWGTYVTQIIIGLCFTAIY 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  401 FVVFRTLILQFNMCTPGREDAE--VKLYSKAEYKASRGQTT-AAEPKKELDQAAGILQALGGVGNISSINNCATRLRIAL 477
Cdd:TIGR02005 399 FLVFRFLILKFNIPTPGREDTEeeVKLYSKADYKAKKGDSVeSKRASSGNDKAAYFLQALGGKENIKDVTNCATRLRISV 478

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 532141310  478 HDMSQTLDDEVFKKLGAHGVFRSGDAIQVIIGLHVSQLREQLDSLI 523
Cdd:TIGR02005 479 KDESKVLDDEVFKKAGAHGVVRSGKAIQVIVGLSVPQVREAFEQLV 524
PRK09702 PRK09702
PTS sugar transporter subunit IIB;
378-538 1.35e-112

PTS sugar transporter subunit IIB;


Pssm-ID: 77355 [Multi-domain]  Cd Length: 161  Bit Score: 331.29  E-value: 1.35e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 378 MFSNHADMMLTQIAIGLCFTLLYFVVFRTLILQFNMCTPGREDAEVKLYSKAEYKASRGQTTAAEPKKELDQAAGILQAL 457
Cdd:PRK09702   1 MFSNHADMMLTQIAIGLCFTLLYFVVFRTLILQFNMCTPGREDAEVKLYSKAEYKASRGQTTAAEPKKELDQAAGILQAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 458 GGVGNISSINNCATRLRIALHDMSQTLDDEVFKKLGAHGVFRSGDAIQVIIGLHVSQLREQLDSLINSHQSAENVAITEA 537
Cdd:PRK09702  81 GGVGNISSINNCATRLRIALHDMSQTLDDEVFKKLGAHGVFRSGDAIQVIIGLHVSQLREQLDSLINSHQSAENVAITEA 160


                 .
gi 532141310 538 V 538
Cdd:PRK09702 161 V 161
pts-Glc TIGR00852
PTS system, maltose and glucose-specific subfamily, IIC component; The PTS Glucose-Glucoside ...
 60-358 1.51e-86

PTS system, maltose and glucose-specific subfamily, IIC component; The PTS Glucose-Glucoside (Glc) Family (TC 4.A.1) Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the E. coli PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. This model is specific for the IIC domain of the Glc family PTS transporters. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273299  Cd Length: 289  Bit Score: 269.19  E-value: 1.51e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310   60 GWTVFRNMPLIFAVGLPIGLAKQAQGRACLAVMVSFLTWNYFINAMGMTWGSYFGVDFTQDAVAGSGLTMMAGIktldts 139
Cdd:TIGR00852   1 GSAAFFFLPLLFAIGAAKGFGGNPYLGAALAGILVHPVLNNAMGVGAQAVGNFFGFEIAKVGYTGVVGPIIVGA------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  140 iigaiiisgIVTALHNRLFDKKLPVFLGIFQGTSYVVIIAFLVMIPCAWLTLLGWPKVqmGIESLQAFLRSAG-ALGVWV 218
Cdd:TIGR00852  75 ---------IALALHERFLDKKLPDVLGFFLGPRFVVIIAGFVAILLIGPLGRVWPPV--GISALLHWLYSAGgALGGAI 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  219 YTFLERILIPTGLHHFIYGPFIF--GPAAVEGGIQMYWAQHLQEFSLSAEPLKSLFPEGGFALHG----NSKIFGAVGIS 292
Cdd:TIGR00852 144 FGFLYRLLVPTGLHHIFYAIFIQliAGGTVIGGGQVIPGDALANMAQGGAALAVFFTAGDAKFKSiglpAAFSAGLGITE 223

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 532141310  293 LAMYFTAAPENRVKVAGLLIPATLTAMLVGITEPLEFTFLFISPLLFAVHAVLAASMSTVMYLFGV 358
Cdd:TIGR00852 224 PAMYGVALRERRPFVAGLIGSALLTAFLTGITEPLEFLFLFGAPGLYSIHAVLAGSIFTVAIGMGI 289
PTS-II-BC-nag TIGR01998
PTS system, N-acetylglucosamine-specific IIBC component; This model represents the combined B ...
 1-519 2.63e-83

PTS system, N-acetylglucosamine-specific IIBC component; This model represents the combined B and C domains of the PTS transport system enzyme II specific for N-acetylglucosamine transport. Many of the genes in this family also include an A domain as part of the same polypeptide and thus should be given the name "PTS system, N-acetylglucosamine-specific IIABC component". This family is most closely related to the glucose-specific PTS enzymes. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273920 [Multi-domain]  Cd Length: 475  Bit Score: 267.02  E-value: 2.63e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310    1 MLSQIQRFGGAMFTPVLLFPFAGIVVGlaillqnpmfVGESLTDPNSLFAQIvhiIEEGGWTVFRNMPLIFAVGLPIGLA 80
Cdd:TIGR01998   1 ILGYFQKLGRALMLPIATLPVAALLLR----------IGNATHGADLLVANF---FIAAGGAIFDNLGLLFAIGVAIGMS 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310   81 KQAQGRACLAVMVSfltwnYFINAMG---MTWGSYFGVDFTQDAVAGSGLTMMAGIKTldtsiigaiiiSGIVTALHNRL 157
Cdd:TIGR01998  68 KDNDGAAALAGLVA-----YFVVTKVlspPPLAAALGIKSEINMAFSAWKNVFVGILA-----------GLIAGALYNRF 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  158 FDKKLPVFLGIFQGTSYVVIIAFLVMIPCAWLTLLGWPKVQMGIESLQAFLRSAGALGVWVYTFLERILIPTGLHHFIYG 237
Cdd:TIGR01998 132 SEIKLPEALSFFSGKRLVPIMAGFVGLVLAALLGYVWPTLYGGIVAFGESISGLGALGAGIYGFLNRLLIPTGLHHALNS 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  238 PFIFGPAAVeGGIQMYWA-QHLQEFSLSAeplkSLFPEGGFALhgnsKIFGAVGISLAMYFTAAPENRVKVAGLLIPATL 316
Cdd:TIGR01998 212 VFWFDVAGI-NDFGNFTGgGDLNRFKGIA----GMFMAGFFPI----MMFGLPAAALAMYHTARPERRKQVGGMLLSVAF 282

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  317 TAMLVGITEPLEFTFLFISPLLFAVHAVLAASMSTVMYLFGVVGNMG--GGLIDQVLpqNWIPMFSNHADMMLTQiaiGL 394
Cdd:TIGR01998 283 ASFLTGVTEPLEFSFMFLAPVLYALHALLTGLSLFIAAMLHWTAGFSfsAGLIDYVL--SFNNPTANQPLMLLVQ---GL 357

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  395 CFTLLYFVVFRTLILQFNMCTPGREDAEVklyskaEYKASRGQTTAAEPKKELdqAAGILQALGGVGNISSINNCATRLR 474
Cdd:TIGR01998 358 VFFALYYVVFRFAIRRFNLKTPGREDEDP------EGATAAAVTSTGDSKMQL--AKQYLAALGGHDNLVSIDACITRLR 429

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 532141310  475 IALHDMSQtLDDEVFKKLGAHGVFRSGD-AIQVIIGLHVSQLREQL 519
Cdd:TIGR01998 430 LTLKDTSI-VDEPALKALGARGVVKLGKhNLQVILGPLAEIVAGEM 474
PRK10110 PRK10110
PTS maltose transporter subunit IICB;
6-527 7.83e-72

PTS maltose transporter subunit IICB;


Pssm-ID: 182245 [Multi-domain]  Cd Length: 530  Bit Score: 238.48  E-value: 7.83e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310   6 QRFGGAMFTPVLLFPFAGIVVGL------AILLQNPMFVGesltdpNSLFAQIVHIIEEGGWTVFRNMPLIFAVGLPIGL 79
Cdd:PRK10110  16 QQLGKTFMLPVALLSFCGIMLGIgsslssHDVITLIPFLG------NPVLQAIFTWMSKIGSFAFSFLPVMFCIAIPLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  80 AKQAQGRACLAVMVSFLTWNYFINamgmTWGSYFGVDFTQDAVA--GSGLTMMAGIKTLDTSIIGAIIISGIVTALHNRL 157
Cdd:PRK10110  90 ARENKGVAAFAGFVGYAVMNLAVN----FWLTNKGILPTTDAAVlkANNIQSILGIQSIDTGILGAVIAGIIVWMLHERF 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 158 FDKKLPVFLGIFQGTSYVVIIAFLVMIPCAWLTLLGWPKVQMGIESLQAFLRSAGALGVWVYTFLERILIPTGLHHFIYG 237
Cdd:PRK10110 166 HNIRLPDALAFFGGTRFVPIISSLVMGLVGLVIPLVWPIFAMGISGLGHMINSAGDFGPMLFGTGERLLLPFGLHHILVA 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 238 PFIFGPAA---------VEGGIQMYWAQhlqefsLSAePLKSLFPEGGFALHGNSK----IFGAVGISLAMYFTAAPENR 304
Cdd:PRK10110 246 LIRFTDAGgtqevcgqtVSGALTIFQAQ------LSC-PTTHGFSESATRFLSQGKmpafLGGLPGAALAMYHCARPENR 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 305 VKVAGLLIPATLTAMLVGITEPLEFTFLFISPLLFAVHAVLAASMSTVMYLFGV-VGNMGGGLID-------QVLPQNWi 376
Cdd:PRK10110 319 HKIKGLLISGVIACVVGGTTEPLEFLFLFVAPVLYVIHALLTGLGFTVMSVLGVtIGNTDGNIIDfvvfgilHGLSTKW- 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 377 pmfsnhadmMLTQIAIGLCFTlLYFVVFRTLILQFNMCTPGREDaevklyskaEYKASRGQTTAAEPKKELDQAAGILQA 456
Cdd:PRK10110 398 ---------YMVPVVAAIWFV-VYYVIFRFAITRFNLKTPGRDS---------EVASSIEKAVAGAPGKSGYNVPAILEA 458

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 532141310 457 LGGVGNISSINNCATRLRIALHDMSQtLDDEVFKKLGAHGVFR-SGDAIQVIIGLHVSQLREQLDSLINSHQ 527
Cdd:PRK10110 459 LGGADNIVSLDNCITRLRLSVKDMSL-VDVQALKDNRAIGVVQlNQHNLQVVIGPQVQSVKDEMAGLMHTVQ 529
PtsG1 COG1263
Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific ...
 1-520 9.06e-71

Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism];


Pssm-ID: 440875 [Multi-domain]  Cd Length: 463  Bit Score: 233.68  E-value: 9.06e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310   1 MLSQIQRFGGAMFTPVLLFPFAGIVVGLAILLQNPMFVGEsltdpNSLFAQIVHIIEEGGWTVFRNMPLIFAVGLPIGLA 80
Cdd:COG1263    8 LFRFLQKIGGIFMPPIPVLPAAGLLLGLGALLTNPGLLGE-----GSFLSGTYQILNAAGDAVFYFLPLLFAIGAAKGFG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  81 kqaqGRACLAVMVSFLTWNYFINAMGMTWGSYFGVDFTQDAVAGSGlTMMAGIktldtsiigaiiISGIVTALHNRLFDK 160
Cdd:COG1263   83 ----GNPALAAVIGYLLVHPTLLNAYAVAGGYISFLGIPTLIGYQG-GVFPGI------------LAGWLAAYLEKFLKK 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 161 KLPVFLGIFqgtsYVVIIAFLVMIPCAwLTLLG--WPKVQMGI-ESLQAFLRSAGALGVWVYTFLERILIPTGLHHFIYG 237
Cdd:COG1263  146 KLPDALGFF----FVPILTLLIMVPLA-LLVIGpiWPPIGNGIaAGLGWIYGLAGAIGGFIYGFLYRLLVPTGLHHGLNP 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 238 PFIFgPAAVEGGIqmywaqhlqefslsaeplkslfpeGGFALHGnSKIFGAVGISLAMYFTAAPenRVKVAGLLIPATLT 317
Cdd:COG1263  221 IFWF-LLGGTGDD------------------------GLFPILA-AAMFGQPGAALAVYLKAKP--NKKVKGLAISAALT 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 318 AMLVGITEPLEFTFLFISPLLFAVHAVLAASMSTVMYLFGVVGNM--GGGLIDqvlpqnwIPMFSNHADMMLTQIAIGLC 395
Cdd:COG1263  273 AFLTGITEPAEFGFNLVAPKLFIAHAIGGGLGGAIAGLLGVKAFSfgVGGLID-------FPSILNPGATNLLLYLIGLV 345

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 396 FTLLYFVVFRTLIlqfnmctpGREDAEVKLYSKAEYKASRGQTTAAEPKKELDQAAGILQALGGVGNISSINNCATRLRI 475
Cdd:COG1263  346 IAFVYYFVFTFLI--------GREDEEEEEKLATKADAKKEEAEAAAAALGGGGGLLLLEADITVLLLTLVDVVIVVVKD 417

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 532141310 476 ALHDMSQTLDDEVFKKLGAHGVFRSGDAIQVIIGLHVSQLREQLD 520
Cdd:COG1263  418 VVKLAAAGAVVVGVGGVGAVGGVGGGGVVIVIVIIILVVVLEGLG 462
PRK11089 PRK11089
PTS system glucose-specific transporter subunits IIBC; Provisional
 3-526 1.08e-68

PTS system glucose-specific transporter subunits IIBC; Provisional


Pssm-ID: 182955 [Multi-domain]  Cd Length: 477  Bit Score: 228.83  E-value: 1.08e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310   3 SQIQRFGGAMFTPVLLFPFAGIVVGlaillqnpmfVGESltDPNSLFAQIVHIIEEGGWTVFRNMPLIFAVGLPIGLAKQ 82
Cdd:PRK11089   7 ANLQKVGKSLMLPVSVLPIAGILLG----------VGSA--NFSWLPAVVSHVMAEAGGSVFANMPLIFAIGVALGFTNN 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  83 aQGRACLAVMVSfltwnYFINAMGMTwgsyfgvdFTQDAVAGSGLTMMAGIKTLDTSIIGAIIISGIVTALHNRLFDKKL 162
Cdd:PRK11089  75 -DGVSALAAVVA-----YGIMVKTMA--------VVAPLVLHLPAEEIAAKHLADTGVLGGIIAGAIAAYMFNRFYRIKL 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 163 PVFLGIFQGTSYVVIIAFLVMIPCAWLTLLGWPKVQMGIESLQ---AFLRSAGALGVwvYTFLERILIPTGLHHFIYGPF 239
Cdd:PRK11089 141 PEYLGFFAGKRFVPIISGLAAIFTGVVLSFIWPPIGSAIQTFSqwaAYQNPVVAFGI--YGFVERSLVPFGLHHIWNVPF 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 240 IF--------GPAAVEGGIQMYWAQHLQEFSLSaeplkslfpeGGFALhgnsKIFGAVGISLAMYFTAAPENRVKVAGLL 311
Cdd:PRK11089 219 QMqigeytnaAGQVFHGDIPRYMAGDPTAGKLS----------GGFLF----KMYGLPAAAIAIWHSAKPENRAKVGGIM 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 312 IPATLTAMLVGITEPLEFTFLFISPLLFAVHAVLAASMSTVMYLFGVVG--NMGGGLIDQVLpqnwipmFSNHADMMLTQ 389
Cdd:PRK11089 285 ISAALTSFLTGITEPIEFSFMFVAPILYIIHAILAGLAFPICILLGMRDgtSFSHGLIDFIV-------LSGNSSKLWLF 357

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 390 IAIGLCFTLLYFVVFRTLILQFNMCTPGREDaevklySKAEYKASRGQTTAAEpkkeldqaagILQALGGVGNISSINNC 469
Cdd:PRK11089 358 PIVGIGYAIVYYTIFRVLIKALDLKTPGRED------ETEDAKATGTSEMAPA----------LVAAFGGKENITNLDAC 421

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 532141310 470 ATRLRIALHDMSQtLDDEVFKKLGAHGVFRSGDAIQVIIGLHVSQLREQLDSLINSH 526
Cdd:PRK11089 422 ITRLRVSVADVSK-VDQAGLKKLGAAGVVVAGSGVQAIFGTKSDNLKTEMDEYIRNH 477
PRK10255 PRK10255
PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional
 1-523 1.90e-52

PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional


Pssm-ID: 182338 [Multi-domain]  Cd Length: 648  Bit Score: 188.93  E-value: 1.90e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310   1 MLSQIQRFGGAMFTPVLLFPFAgivvglAILLQnpmfvgesLTDPNSLFaqiVHIIEEGGWTVFRNMPLIFAVGLPIGLA 80
Cdd:PRK10255   3 ILGFFQRLGRALQLPIAVLPVA------ALLLR--------FGQPDLLN---VAFIAQAGGAIFDNLALIFAIGVASSWS 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  81 KQAQGRACLAVMVSfltwnYFINAMGMTwgsyfgvdfTQDAVAGSGLtmMAGIKTldtsiigaiiiSGIVTALHNRLFDK 160
Cdd:PRK10255  66 KDSAGAAALAGAVG-----YFVLTKAMV---------TINPEINMGV--LAGIIT-----------GLVGGAAYNRWSDI 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 161 KLPVFLGIFQGTSYVVI-IAFLVMIPCAWLTLLgWPKVQMGIESLQAFLRSAGALGVWVYTFLERILIPTGLHH------ 233
Cdd:PRK10255 119 KLPDFLSFFGGKRFVPIaTGFFCLVLAAIFGYV-WPPVQHAIHAGGEWIVSAGALGSGIFGFINRLLIPTGLHQvlntia 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 234 -FIYGPFIFGPAAV-EGGIQMYWAqhlqefslsAEPLKSLFPEGGFALhgnsKIFGAVGISLAMYFTAAPENRVKVAGLL 311
Cdd:PRK10255 198 wFQIGEFTNAAGTVfHGDINRFYA---------GDGTAGMFMSGFFPI----MMFGLPGAALAMYFAAPKERRPMVGGML 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 312 IPATLTAMLVGITEPLEFTFLFISPLLFAVHAVLAASMSTVMYLFGVVG--NMGGGLIDQVLPQNwIPMFSNHADMMLTq 389
Cdd:PRK10255 265 LSVAVTAFLTGVTEPLEFLFMFLAPLLYLLHALLTGISLFVATLLGIHAgfSFSAGAIDYALMYN-LPAASQNVWMLLV- 342

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 390 iaIGLCFTLLYFVVFRTLILQFNMCTPGREDAEvklyskAEYKASRGQTTAAEPKKELdqAAGILQALGGVGNISSINNC 469
Cdd:PRK10255 343 --MGVVFFAIYFVLFSAVIRMFNLKTPGREDKE------DEIVTEEANSNTEEGLTQL--ATNYIAAVGGTDNLKAIDAC 412

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 532141310 470 ATRLRIALHDmSQTLDDEVFKKLGAHGVFR-SGDAIQVIIGLHVSQLREQLDSLI 523
Cdd:PRK10255 413 ITRLRLTVAD-SARVNDAMCKRLGASGVVKlNKQTIQVIVGAKAESIGDAMKKVV 466
PTS_EIIC pfam02378
Phosphotransferase system, EIIC; The bacterial phosphoenolpyruvate: sugar phosphotransferase ...
 9-347 7.05e-51

Phosphotransferase system, EIIC; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyzes the transfer of a phosphoryl group from IIB to the sugar substrate.


Pssm-ID: 367061  Cd Length: 315  Bit Score: 176.77  E-value: 7.05e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310    9 GGAMFTPVLLFPFAGIVVGLAILLQNPMFVGESLTDPNSLFAqivHIIEEGGWTVFRNMPLIFAVGLPIGLAkQAQGRAC 88
Cdd:pfam02378   1 GDGFMPPIPLLIAGGILLGLGNLPNDTTGLPAGGFTGDSPLA---EILKQAGSAAFGILPILFAIGIAYGLA-GGDGVAG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310   89 LAVMVSFLTWNY--FINAMGMTWGsyfgvdftqdavaGSGLTMMAGIKTLDTSIIGAIIISGIVTALHNRLFD---KKLP 163
Cdd:pfam02378  77 AAGLIGLLSFNLaaAISVALTAAG-------------LSGGGNILGIGLGATGVFGAIIPGLLAAYLYNRFEKnitIKLP 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  164 VFLGIFQGTSYVVII-AFLVMIPCAWLTLLGWPKVQMGIESLQAFLRSAG-ALGVWVYTFLERILIPTGLHHFIYGPFIF 241
Cdd:pfam02378 144 DSLPFFVGKRFVPIItGFVTLLVIGPVLGLIWPAIQGGLNALGLLLIIAGgILGGLIFGFLERLLWPFGLHGAFIAIFWF 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  242 ---GPAAVEGGIQMYWAqhlqefslsaeplkslfpEGGFALHGN-SKIFGAVGISLAMYFTAAPENRVKVAGLLIPATLT 317
Cdd:pfam02378 224 lpiGGSNPIANQQAYGA------------------GAAHILTGGfDVMFGGPGATLALYAAAFLFKKSKVKKLLGSAALT 285

                         330       340       350
                  ....*....|....*....|....*....|
gi 532141310  318 AMLVGITEPLEFTFLFISPLLFAVHAVLAA 347
Cdd:pfam02378 286 PFLFGITEPLEFGFPFVLNPPFFIPAILAG 315
EIIB_glc TIGR00826
PTS system, glucose-like IIB component; The PTS Glucose-Glucoside (Glc) Family (TC 4.A.1) ...
 409-509 6.21e-30

PTS system, glucose-like IIB component; The PTS Glucose-Glucoside (Glc) Family (TC 4.A.1) Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the E. coli PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. This model is specific for the IIB domain of the Glc family PTS transporters. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273288 [Multi-domain]  Cd Length: 88  Bit Score: 112.45  E-value: 6.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310  409 LQFNMCTPGREDAEVKlyskaeykasrgQTTAAEPKKELDQAAGILQALGGVGNISSINNCATRLRIALHDMSQTlDDEV 488
Cdd:TIGR00826   1 TRLRLKTPGREKADEE------------AIAAGEGVKGVFTAAGQIQALGGTGNVNKVDACITRLRVGVADVSKV-DDAV 67

                          90       100
                  ....*....|....*....|.
gi 532141310  489 FKKLGAHGVFRSGDAIQVIIG 509
Cdd:TIGR00826  68 LKKLGAHGVNPLQRAVQVISG 88
PtsG2 COG1264
Phosphotransferase system IIB components [Carbohydrate transport and metabolism];
448-523 8.76e-28

Phosphotransferase system IIB components [Carbohydrate transport and metabolism];


Pssm-ID: 440876 [Multi-domain]  Cd Length: 76  Bit Score: 105.97  E-value: 8.76e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 532141310 448 DQAAGILQALGGVGNISSINNCATRLRIALHDMSQtLDDEVFKKLGAHGVFRSGDAIQVIIGLHVSQLREQLDSLI 523
Cdd:COG1264    2 ELAKDILEALGGKENIVSVDHCATRLRVTVKDPSK-VDEAALKKLGVKGVVKNGGQVQVIIGPGVDKVADEIEKLL 76
PTS_IIB_glc cd00212
PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: ...
 448-523 1.23e-23

PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation


Pssm-ID: 238130 [Multi-domain]  Cd Length: 78  Bit Score: 94.52  E-value: 1.23e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 532141310 448 DQAAGILQALGGVGNISSINNCATRLRIALHDMSQtLDDEVFKKL-GAHGVFRSGDAIQVIIGLHVS-QLREQLDSLI 523
Cdd:cd00212    2 QLAKDILEALGGKENIVSLDHCATRLRLTVKDESK-VDEAALKKLgGVKGVVKNGGQYQVIIGPGVAdVYKEAIKLLG 78
PTS_EIIB pfam00367
phosphotransferase system, EIIB;
453-482 3.46e-11

phosphotransferase system, EIIB;


Pssm-ID: 459785 [Multi-domain]  Cd Length: 32  Bit Score: 57.76  E-value: 3.46e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 532141310  453 ILQALGGVGNISSINNCATRLRIALHDMSQ 482
Cdd:pfam00367   3 ILEALGGKENIKSVDHCATRLRLTVKDESK 32
PRK09796 PRK09796
PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional
 450-524 3.14e-08

PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional


Pssm-ID: 182081  Cd Length: 472  Bit Score: 55.96  E-value: 3.14e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 532141310 450 AAGILQALGGVGNISSINNCATRLRIALHDMSQTLDDEVFKKLGAHGVFRSGDAIQVIIGLHVSQLREQLDSLIN 524
Cdd:PRK09796   9 ARSVIAALGGVDNISAVTHCMTRLRFVIKDDALIDSPTLKTIPGVLGVVRSDNQCQVIIGNTVSQAFQEVVSLLP 83
murP PRK09586
PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed
 453-533 1.31e-07

PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed


Pssm-ID: 181971 [Multi-domain]  Cd Length: 476  Bit Score: 54.30  E-value: 1.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 453 ILQALGGVGNISSINNCATRLRIALHDmSQTLDDEVFKKL-GAHGVFRSGDAIQVIIGLHVSQ-----LREQLDSLINSH 526
Cdd:PRK09586  12 ILTRVGGPGNIASCGNCMTRLRLTLHD-SSLVDPAAIKTIeGVKGVILSDDQVQVVLGPGKAQraakaMNELLGEAAAPV 90


                 ....*..
gi 532141310 527 QSAENVA 533
Cdd:PRK09586  91 QDLAEIA 97
PTS-II-ABC-beta TIGR01995
PTS system, beta-glucoside-specific IIABC component; This model represents a family of PTS ...
 448-513 4.72e-07

PTS system, beta-glucoside-specific IIABC component; This model represents a family of PTS enzyme II proteins in which all three domains are found in the same polypeptide chain and which appear to have a broad specificity for beta-glucosides including salicin (beta-D-glucose-1-salicylate) and arbutin (Hydroquinone-O-beta-D-glucopyranoside). These are distinct from the closely related sucrose-specific and trehalose-specific PTS transporters.


Pssm-ID: 273919 [Multi-domain]  Cd Length: 610  Bit Score: 52.35  E-value: 4.72e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 532141310  448 DQAAGILQALGGVGNISSINNCATRLRIALHDMSQTLDDEVFKKLGAHGVFRSGDAIQVIIGLHVS 513
Cdd:TIGR01995   3 DLAKAIIENVGGKENIESVTHCATRLRFTLKDDAKADTEKLKKISGVITVVKSGGQYQVVIGNDVN 68
PTS-II-BC-sucr TIGR01996
PTS system, sucrose-specific IIBC component; This model represents the fused enzyme II B and C ...
 450-509 4.46e-06

PTS system, sucrose-specific IIBC component; This model represents the fused enzyme II B and C components of the sucrose-specific PTS sugar transporter system. Sucrose is converted to sucrose-6-phosphate in the process of translocation into the cell. Some of these transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). The exceptions to this rule are Staphylococci, Streptococci, Lactococci, Lactobacilli, etc. which contain their own A domain as a C-terminal fusion. This family is closely related to the trehalose transporting PTS IIBC enzymes and the B and C domains of each are described by subfamily-domain level TIGRFAMs models (TIGR00826 and TIGR00852, respectively).


Pssm-ID: 131051  Cd Length: 461  Bit Score: 49.22  E-value: 4.46e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 532141310  450 AAGILQALGGVGNISSINNCATRLRIALHDMSQtLDDEVFKKL-GAHGVFRSGDAIQVIIG 509
Cdd:TIGR01996   6 AKEILELLGGKDNIVSVAHCATRLRLVLKDESK-IDKKAIENLdGVKGTFFNSGQYQIIIG 65
PRK09824 PRK09824
PTS system beta-glucoside-specific transporter subunits IIABC; Provisional
 450-513 6.27e-06

PTS system beta-glucoside-specific transporter subunits IIABC; Provisional


Pssm-ID: 236627 [Multi-domain]  Cd Length: 627  Bit Score: 48.94  E-value: 6.27e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 532141310 450 AAGILQALGGVGNISSINNCATRLRIALHDmSQTLDDEVFKK-LGAHGVFRSGDAIQVIIGLHVS 513
Cdd:PRK09824   7 AREIVAGVGGADNIVSLMHCATRLRFKLKD-NSKAQAEVLKKnPGVIMVVESGGQFQVVIGNHVA 70
PRK14905 PRK14905
triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; ...
 432-523 1.43e-04

triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional


Pssm-ID: 184898 [Multi-domain]  Cd Length: 355  Bit Score: 44.25  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532141310 432 KASRGQTTAAEPKKELDQAAGILQALGGVGNISSINNCATRLRIALHDMSQTLDDEVFKKLGAHGVFRSGDAIQVIIGLH 511
Cdd:PRK14905 260 KALAGSKIDPIIHKFSEIAIQLIDHLGGKDNISALTHCASRIRVMLRNDGHIDKSAIEKIDCVKGLFSIANQYQIILGAG 339

                         90
                 ....*....|...
gi 532141310 512 -VSQLREQLDSLI 523
Cdd:PRK14905 340 iVEKIHEEMKALL 352
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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