|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
17-412 |
3.38e-127 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 373.60 E-value: 3.38e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 17 LGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAG 96
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 97 SWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFI 176
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 177 WAMAWLIFYKHPRDQKHLTDEERDYIINGQ----EAQHQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPL 252
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWLTEEEKYIVVGGllaeQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 253 FMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFQRWfGVNLIVSRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLL 332
Cdd:TIGR00893 241 YLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRR-GKSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALALV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 333 CIGGFAHQAlSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIG-FSPLFAVLAVFDLLGALVIWTV 411
Cdd:TIGR00893 320 ALGFFGLGA-GAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGsFAGALMVVAALALIGALSYLLL 398
|
.
gi 56480256 412 L 412
Cdd:TIGR00893 399 V 399
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
8-411 |
2.13e-88 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 272.91 E-value: 2.13e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAV 87
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 88 FCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 168 IISGALSFIWAMAWLIFYkhprdqkhltdeerdyiingqeaqhqvstakkmsvgqilrnRQFWGIALPRFLAEPAWGTFN 247
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL-----------------------------------------RQVWGLALGYFGINYALYGLL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 248 AWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFQRWfgvnliVSRKMVVTLGAVLMIGPGMIGLFTNPYV 327
Cdd:cd17319 200 TWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG------ARRLVIIIGLLLAAVGLLLAYLTTSPVV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 328 AIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALAD-TIGFSPLFAVLAVFDLLGAL 406
Cdd:cd17319 274 AVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGSYTAAFLFLAAVALLAAL 353
|
....*
gi 56480256 407 VIWTV 411
Cdd:cd17319 354 LVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-412 |
1.54e-62 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 206.26 E-value: 1.54e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 1 MRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAM 80
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 81 FAVLWAVFCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM 160
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 161 HSWQMAFIISGALSFIWAMAwlifykhprdqkhltdeerdyiingqeaqhqvstakkmsvgqilrnrQFWGIALPRFLAE 240
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL-----------------------------------------------RFWLLALAYFLVY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 241 PAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFQRwfgvnlivSRKMVVTLGAVLM-IGPGMI 319
Cdd:COG2271 194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR--------RRKLVLAIGLLLAaLALLLL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 320 GLFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAV 399
Cdd:COG2271 266 ALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAA 345
|
410
....*....|...
gi 56480256 400 FDLLGALVIWTVL 412
Cdd:COG2271 346 LALLAALLALLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-421 |
6.06e-43 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 155.04 E-value: 6.06e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAV 87
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 88 FCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 168 IISGALSFIWAMAWLIFYKHPrdqkhltdeerdyiingQEAQHQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFN 247
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDP-----------------PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 248 AWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFQRwfgvnlivsRKMVVTLGAVLMIGPGMIGLFT-NPY 326
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG---------RRVLLIVFALMALGLLLLALALgSLW 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 327 VAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIG-FSPLFAVLAVFDLLGA 405
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVAL 376
|
410
....*....|....*.
gi 56480256 406 LVIWTVLQNKPAIEVA 421
Cdd:COG2223 377 VLTLLLYRRPRRAAAA 392
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-376 |
1.08e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 120.85 E-value: 1.08e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 1 MRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAM 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 81 FAVLWAVFCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM 160
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 161 HSWQMAFIISGALSFIwAMAWLIFYKHprdqkhltdeerdyiingqEAQHQVSTAKKMSVGQILRNRQFWGIALPRFLAE 240
Cdd:COG2814 161 FGWRWVFLVNAVLALL-ALLLLLRLLP-------------------ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 241 PAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFQRwfgvnlivsRKMVVTLGAVLMIGPGMIG 320
Cdd:COG2814 221 FGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR---------RRLLLIGLLLLALGLLLLA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 56480256 321 LFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTL 376
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
16-394 |
5.05e-30 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 119.79 E-value: 5.05e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 16 TLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALA 95
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 96 GSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMH-SWQMAFIISGALS 174
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 175 FIWAMAWLIFYKHPRDQKHLT--DEER-DYIINGQEAQHQVSTAKKMSVGQILRNRQFWGIALPR-FLAEPAWGtFNAWI 250
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPpaEEMPnEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYvFVYVVRTG-ILDWS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 251 PLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLF--QRWFGVNLIVSRKMVVTLGAVLMIgpgmigLFTNPYVA 328
Cdd:TIGR00881 240 PLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLN------PAANPLMD 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 56480256 329 IMLLCIGGF---AHQALSGaliTLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLF 394
Cdd:TIGR00881 314 LICLFALGFlvyGPQMLIG---VIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-378 |
5.18e-29 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 116.36 E-value: 5.18e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 15 VTLGTVLGYLTRNTVAAAAP-TLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATA 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 94 LAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGAL 173
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 174 SFIWAMAWLIFYKHPRDQKHLTDEERDYIIngqeaqhqvstakkMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLF 253
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSL--------------IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 254 MfKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFQRWFgvnlivSRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLC 333
Cdd:pfam07690 227 Q-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR------RLLLALLLLILAALGLLLLSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 56480256 334 IGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFA 378
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
34-409 |
3.79e-28 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 114.21 E-value: 3.79e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 34 PTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAVARGAVGAAEA 113
Cdd:cd17325 20 PLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 114 AMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIwAMAWLIFYKHPRDQKH 193
Cdd:cd17325 100 AVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL-ALVLALLLLPEPRPPP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 194 LTDEERDYIINGqeaqhqvstakkmSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPM 273
Cdd:cd17325 179 NKRAVSAARLRS-------------GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 274 LFADLGCILGGYLPplfqRWFGvnlivsRKMVVTLGAVLM-IGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSD 352
Cdd:cd17325 246 LASALSQPPAGKLS----DRIG------RKPLILIGLLLSaVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAD 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 56480256 353 VFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17325 316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-409 |
3.64e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 108.67 E-value: 3.64e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 15 VTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATAL 94
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 95 AGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAI--VMHSWQMAFIISGA 172
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 173 LSFIWAMAWLIFYKHPRDQKhltdeerdyiinGQEAQHQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPL 252
Cdd:cd06174 161 LALLAAILLLLVVPDPPESA------------RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 253 FMFKVYGFNLKEIAMFAWMPMLFADLGCILGGylpplfqrWFGVNLIVSRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLL 332
Cdd:cd06174 229 FLLDLGGLSVAVAGLLLSLFGLAGALGSLLLG--------LLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56480256 333 CIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALAD-TIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd06174 301 LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
5-409 |
6.71e-22 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 96.85 E-value: 6.71e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 5 KGLRWYMIALVTLGTVLGYLTrNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVL 84
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFAT-ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 85 WAVFCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIaVGYFNVGSSIGAMIAPPLVVWAIVMH--- 161
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGlsl 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 162 SWQMAFIISGALSFIwAMAWLIFYKHPRDqkhltdeerdyiingqEAQHQVSTAKKMSVGQILRNRQFWGIALPRFLAEP 241
Cdd:COG0738 162 SWHLPYLILAVLLLL-LALLFLRSKLPEI----------------EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 242 AWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLpplfqrwfgVNLIVSRKMVVTLGAVLMIGPGMIGL 321
Cdd:COG0738 225 AEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFL---------LKRFGPVRLLRLSALLAAVGLLLALL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 322 FTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAwLASTLFALVVGALADTIGFSPLFAVLAVFD 401
Cdd:COG0738 296 APGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPLIGFLADAFGLRAAFLVPLVCY 374
|
....*...
gi 56480256 402 LLGALVIW 409
Cdd:COG0738 375 LLILLLAL 382
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
11-409 |
7.08e-22 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 96.53 E-value: 7.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 11 MIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTK--IGYAMFAvlWAVF 88
Cdd:cd17318 22 IVAMVNSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKrvLGYSILI--TALL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 89 CGATALA--GSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMA 166
Cdd:cd17318 100 TLLTPLAarGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSI 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 167 FIISGALSFIWAMAWLIFYkhprdqkhltdeerdyiingqeaqhqvstakkmsvgqilrnRQFWGIALPRFLAEPAWGTF 246
Cdd:cd17318 180 FYIFGGLGLLWCLLWFFLV-----------------------------------------LPVWAIVVAHFGHNWGFYTL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 247 NAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFQRWFGVNLIVSRKMVVTLG----AVLMIGPGMIGlf 322
Cdd:cd17318 219 LTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKLFTSIGflgpGVFLIALGYLG-- 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 323 TNPYVAIMLLCI----GGFAHQALSGALITLSSDVFGrnevaTANGLTGMSAWLASTLFALVVGAL---ADTIG-FSPLF 394
Cdd:cd17318 297 SNATLAVVFLTLsvglSGACYSGFLVNHLDLAPNYAG-----TLMGITNTAATIAGIISPLIVGAIvknDQTIGqWRIVF 371
|
410
....*....|....*
gi 56480256 395 AVLAVFDLLGALVIW 409
Cdd:cd17318 372 FISAAIYILGAIFYL 386
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
8-406 |
4.44e-21 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 94.62 E-value: 4.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTK----IGYAMFAV 83
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKrflaIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 84 LWAVFCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM--- 160
Cdd:cd17345 81 INILIGFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIfgd 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 161 HSWQMAFIISGALSFIWAMAWLIFYKH-------PRDQKHLTDEERDYIINGQEaqhqvstaKKMSVGQI-----LRNRQ 228
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFLGKDtpeseglPPIEEYKGDYPEEADGEEEE--------QELSAWEIfvkyvLKNKL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 229 FWGIALPR-FLAEPAWGTFNaWIPLFMFKVYGFNLKE----IAMFAWMpmlfADLGCILGGYLPPLFQRwfgvnlivSRK 303
Cdd:cd17345 233 LWYIAIANvFVYLVRYGILD-WAPTYLSEVKGFSKAQamwaFSLFEWA----AIPGTLLAGWLSDKLFK--------GRR 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 304 MVVTLGAVLMIGPGMIGLFTNPYVAIMLLCIggfahqALSGALI--------TLSSDVFGRNEVATANGLTGMSAWLAST 375
Cdd:cd17345 300 APTGIIFMILVIVALIVYWLAPNVLVDLIAL------IALGFLIygpvmligLQALELVPKKAAGTAAGLTGLFGYLGGS 373
|
410 420 430
....*....|....*....|....*....|..
gi 56480256 376 LFA-LVVGALADTIGFSPLFAVLAVFDLLGAL 406
Cdd:cd17345 374 VLAtALIGIIVDHFGWNGGFIVLLASCILAII 405
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
16-409 |
4.44e-19 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 88.45 E-value: 4.44e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 16 TLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALA 95
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 96 GSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGY----FNVGSSIGAMIAPPLVvwaiVMHSWQMAFIISG 171
Cdd:cd17475 82 GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIrqtgVPLGGALAAALLPPLA----LHYGWRAAFVVAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 172 ALSFIWAMAWLIFYKHPRDQKHLTdeerdyiingqeaqhQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIP 251
Cdd:cd17475 158 LVSILAAVLFWLFYREPPAASAAT---------------ESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 252 LFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPplfQRWFGVNLIVSRKMVVTLGAVLMIGPGMIGLFTNPYVAIML 331
Cdd:cd17475 223 LFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVS---DRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 56480256 332 LCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALAD-TIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17475 300 LILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDaTHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
8-412 |
5.79e-19 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 87.71 E-value: 5.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTK------------ 75
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRrfmsaglllsal 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 76 --IGYAMFAVLW--AVFCGATALAGSWGglavargavgaaeaamIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAP 151
Cdd:cd17312 81 anIFMGFSTSLWffAVLWGLNGLFQSMG----------------WPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAP 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 152 PLVVWAIVMHSWQMAFIISGALSFIWAmawLIFYKHPRDqkhltdeerdyiingqeaqhqvstakkmsvgqilRNRQFWG 231
Cdd:cd17312 145 ILAASLASYYGWRAAFLVPGIVGLVVA---IILFFFLRD----------------------------------SPPYVWV 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 232 IALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPplfQRWFGVNlivSRKMVVTLGAV 311
Cdd:cd17312 188 LSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLS---DKLFGGR---RAPIAVIYMLL 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 312 LMIGPGMIGLF-TNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVA-TANGLTGMSAWLASTLFALVVGALADTIG 389
Cdd:cd17312 262 MTLSLALFWFFpHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAgTATGFVGLFGYLGASLAGLPLGYIIDHYG 341
|
410 420
....*....|....*....|...
gi 56480256 390 FSPLFAVLAVFDLLGALVIWTVL 412
Cdd:cd17312 342 WSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-411 |
4.64e-18 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 85.31 E-value: 4.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGA 91
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 92 TALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGaMIAPPLVVWAIVMHSWQMAFIISG 171
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLG-IAVGPLLGGLLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 172 ALSFIWAMAWLIFYKHPRdqkhltdeerdyiingqEAQHQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIP 251
Cdd:cd17474 160 ALIPVAFLAILFLLPEPK-----------------EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 252 LFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFqrwfgvnliVSRKMVVTLGAVLM-IGPGMIGLFTNPYVAIM 330
Cdd:cd17474 223 FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR---------FGARRILVIGLLLYaLSLLLLGFVPSLALLLI 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 331 LLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIWT 410
Cdd:cd17474 294 AIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
.
gi 56480256 411 V 411
Cdd:cd17474 374 L 374
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
39-388 |
1.18e-17 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 84.79 E-value: 1.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 39 ELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTK--IGYAMF--AVLWAVFCGATALAGSWggLAVARGAVGAAEAA 114
Cdd:TIGR00894 70 NFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKwsIGIGMFlsSVISIVIPWAAGGGIAL--VVFCRVIQGLAQGS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 115 MIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVW-AIVMHSWQMAFIISGALSFIWAMAWLIF-YKHPRDQK 192
Cdd:TIGR00894 148 VSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWlCESWGGWPMIFYVFGIVGCAWSLLWFVFpADDPSIHP 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 193 HLTDEERDYiINGQEAQHQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMP 272
Cdd:TIGR00894 228 CISKFEKKY-INSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLP 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 273 MLFADLGCILGGYLPPLFQRWFGVNLIVSRKMVVTLGAVLMIGPGMIGLFT--NPYVAIMLLCI-GGFAHQALSGALItL 349
Cdd:TIGR00894 307 YLFAWLCSIFAGYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLsaAFYLTIIILTLaNAVSSGPLAGVLI-N 385
|
330 340 350
....*....|....*....|....*....|....*....
gi 56480256 350 SSDVFGRnevatANGLTGMSAWLASTLFALVVGALADTI 388
Cdd:TIGR00894 386 SLDLAPR-----FLGFIKGITGLPGFIGGLIASTLAGNI 419
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
13-385 |
1.79e-17 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 83.82 E-value: 1.79e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 13 ALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGAT 92
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 93 ALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAppLVVWAIVMH---SWQMAFII 169
Cdd:cd17328 82 SFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLG--YVVGGLVAQatgGWRWAFRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 170 SGALSFIWAMAWLIFYKHPRDQkhltdeerdyIINGQEAQHQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAW 249
Cdd:cd17328 160 TGVLGVLLAILLLLFVREPPRG----------AAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFW 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 250 IPLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFQRWFGVNLIVSRKMVV---TLGAVLMIGPGMIGLFTNPY 326
Cdd:cd17328 230 APTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCavgLLAAAPFLFLALVLALSNLL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 327 VAIMLLCIGGFAH-----------------------------------QALSGALITLSSDVFGRNEVATANGLTGMSAW 371
Cdd:cd17328 310 LAWVLLFLGEFLLslnwapvfaillyvviptrrstasaiqillshllgDAGSPYLIGLISDLLRQNKDSPLAEAASLQYA 389
|
410
....*....|....
gi 56480256 372 LASTLFALVVGALA 385
Cdd:cd17328 390 LLLCSFVLVLGGFF 403
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
12-407 |
3.44e-17 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 82.60 E-value: 3.44e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGA 91
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 92 TALAGSWG--GLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFII 169
Cdd:cd17380 81 TPLLAYSSlpLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 170 SGALSFIWAMAWLIFYkhprdqkhltdeerdyiingqeaqhqvstakkmsvgqilrnRQFWGIALPRFLAepAWGTFN-- 247
Cdd:cd17380 161 FGLLGLLWALVWLIYL-----------------------------------------PPVWAIIVAHFCM--NWGFYIll 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 248 AWIPLFmFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFQRwFGVNLIVSRKMVVTLGavlMIGPGM----IGLFT 323
Cdd:cd17380 198 SWLPTY-FHEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLIS-RGWTVTSVRKLMQSIG---FLGPALflllLSHTD 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 324 NPYVAIMLLCIG-GFAHQALSGALITLsSDVFGRNEVATAnGLTGMSAWLASTLFALVVGALADTIG-FSPLFAVLAVFD 401
Cdd:cd17380 273 SFSLALLCMSVAlGLSAFSSSGVLVNH-QDIAPNYAGIVF-GISNTAGTIPGIVGVYLTGYILEATGsWSLVFVLAAVVN 350
|
....*.
gi 56480256 402 LLGALV 407
Cdd:cd17380 351 LVGAVV 356
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
29-409 |
1.80e-16 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 80.29 E-value: 1.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 29 VAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAVARGAV 108
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 109 GAAEAAMIPAGLKASSEwFPAKERSIAVGYFNVGSSIGAMIAPpLVVWAIVMHSWQMAFIISGALSFIWAMAWLIFYKHP 188
Cdd:cd17478 95 GIGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGP-LIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 189 RdqkhltdeerdYIINGQEAQHQVSTAKKMSVGQILRNrqFWGIALPRFLAEPAWGTFnawIPlFMFKVYGFNLKEIAMF 268
Cdd:cd17478 173 K-----------KPEAKKAAAKSSARSTLKGVWRALLL--LLIIVFLRSWVLSSLTTF---LP-FYLVQRGYSLVFAGLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 269 AWMPMLFADLGCILGGYLPPLFqrwfgvnlivSRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALIT 348
Cdd:cd17478 236 LSLFLFAGAIGTLIGGPLSDRF----------GRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVV 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56480256 349 LSSDVFGRNeVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17478 306 LAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-409 |
2.60e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 79.90 E-value: 2.60e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 34 PTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAVARGAVGAAEA 113
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 114 AMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIwaMAWLIFYKHPRDQkh 193
Cdd:cd17324 103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALL--AALLLWRLLPSLP-- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 194 ltdeerdyiingqeAQHQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFawmpM 273
Cdd:cd17324 179 --------------PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL----L 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 274 LFADLGCILGGylpPLFQRWfgVNLIVSRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSDV 353
Cdd:cd17324 241 LLFGVAGVVGS---PLAGRL--ADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 56480256 354 FGRNeVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17324 316 APEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-415 |
9.62e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 75.29 E-value: 9.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAV 87
Cdd:COG2807 16 RWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 88 FCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:COG2807 96 GLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 168 IISGALSFIWAMAWLIFYKHPRdqkhltdeerdyiingqeaQHQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFN 247
Cdd:COG2807 175 AVWALLALLALLLWLPLLRRRP-------------------AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 248 AWIPLfMFKVYGFNLkeiAMFAWMPMLFADLGCILGGYLPPLFQRWfgvnliVSRKMVVTLGAVLMIGpGMIGLFTNPYV 327
Cdd:COG2807 236 AWLPP-ILRDAGLSA---ATAGLLLSLFQLAGIPGSLLVPLLADRL------GDRRPLLLLLGLLGLA-GLLGLLLAPGS 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 328 AIMLLCI-GGFAHQALSGALITLSSDVFGR-NEVATANGLTGMSAWLASTLFALVVGALAD-TIGFSPLFAVLAVFDLLG 404
Cdd:COG2807 305 LPWLWAVlLGLGQGGLFPLALTLIGLRARTpAEAAALSGMAQSVGYLLAALGPLLVGALHDaTGSWTAALLLLAALAVLM 384
|
410
....*....|.
gi 56480256 405 ALVIWTVLQNK 415
Cdd:COG2807 385 LVAGLLAGRPY 395
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
9-370 |
1.46e-14 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 74.98 E-value: 1.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 9 WYMIALVTLGTVLGYLTRNTVAAAAPTLM-EELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAV 87
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMGMkEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 88 FCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIApPLVVWAIV-------M 160
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG-GLLAYGVFkilgvggL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 161 HSWQMAFIISGALSFIWAMAWLIFY-KHPRDQKHLTDEERDYIINGQEAQHQVSTAKKMSVGQI---LRNRQFWGIALPR 236
Cdd:cd17327 163 AGWRWLFIIEGLITIIIGLVIFFWLpDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFKWKQIkeaFKDPRTWLLFLFF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 237 FLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFQrwfgvnlivsRKMVVTLGAVL--MI 314
Cdd:cd17327 243 FCSQITNNGISNFLPLIL-KSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFK----------KRGLFAIFACVlaLV 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 56480256 315 GPGMIGLFTNP---YVAIMLLCIGGFAHQALSGALItlSSDVFGRNEVATANGLTGMSA 370
Cdd:cd17327 312 GSIILLAAPNPpgaYFAAYILGGGSYAGFPILLSWI--SSNCAGYTKRATVLAIMLIFY 368
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-177 |
2.51e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 67.14 E-value: 2.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAV 87
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 88 FCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170
....*....|
gi 56480256 168 IISGALSFIW 177
Cdd:COG0477 172 LINAPLGLLA 181
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
36-411 |
4.86e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 66.91 E-value: 4.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 36 LMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAVARGAVGAAEAAM 115
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 116 IPAGLKAS-SEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIWAM-AWLIFYKHPRDQKH 193
Cdd:cd17355 109 LAAVAFATvAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVpVLLLLRRRPADLAL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 194 LTDEERDYIINGqeaqhqvstakkMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPM 273
Cdd:cd17355 189 RAYDDASPASPG------------STLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL-ADRGISPAAAAVALALIG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 274 LFADLGCILGGYlppLFQRWFGVNLIVSRKMVVTLGAVLMIGPGMIGLFTnpYVAIMLLCIGGFAHQALSGALItlsSDV 353
Cdd:cd17355 256 LFNIVGRLLSGW---LGDRYSPRRLLAASYALRALGLALLLLLPFPPLAL--LLFAALFGLGWGATVPLTAALA---ARY 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 56480256 354 FGRNEVATANGLTGMSAWLASTLFALVVGALADTIG-FSPLFAVLAVFDLLGALVIWTV 411
Cdd:cd17355 328 FGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
14-410 |
9.50e-12 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 66.12 E-value: 9.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 14 LVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATA 93
Cdd:cd17341 3 LSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 94 LAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKER----SIAVGYFNVGSSIGAMIAPPLVVWAIVMHS---WQMA 166
Cdd:cd17341 83 LAVSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIggaaGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGfvgWRNA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 167 FIISGALSFIWAMAWLIFYKHPRDQKhltdeerdyiingqeaqhqVSTAKKMSV-GQILRNRQFWGIALPRFLAEPAWGT 245
Cdd:cd17341 163 FFVPGILLAIAAVLVLLFGDDLPTGK-------------------ASALEFLKVqLAVLKNYRTWILSLLYGVTFGSFVG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 246 FNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLF--QRWFGVNLIVsrkMVVTLGAVLMIGPGMIGLFT 323
Cdd:cd17341 224 FSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFggRRRLWWLFIV---MTIGAALLSLSLPTSGTNLV 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 324 nPYVAIMLLCigGFAHQALSGALITLSSDVFgRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPL-FAVLAVFDL 402
Cdd:cd17341 301 -LFLALFVAL--GLGAGAGNGSVFRMVPFIF-RRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGaFSLFGVLAV 376
|
....*...
gi 56480256 403 LGALVIWT 410
Cdd:cd17341 377 ACTLLVWL 384
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
8-411 |
1.58e-11 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 65.71 E-value: 1.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKigyamfavlWAV 87
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPR---------KAI 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 88 FCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKAS----------SEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWA 157
Cdd:cd17353 72 LIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAGigyitpvstaVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 158 IVMHSWQMAFIISGALSFIWAMAWLIFYKHPRDQKHLTDEERDyiingqeAQHQVSTAKKMSVGQILRNRQFWGIALPRF 237
Cdd:cd17353 151 INTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPL-------ANNAENSPRDYTPREMLRTPTFWLLWLMFF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 238 LAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFqrwfgvnlivSRKMVVTLgAVLMIGPG 317
Cdd:cd17353 224 LNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKI----------GRKNTLSI-AFLIQGVA 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 318 MIGLFTNPYVAIMLL---CIGGFAHQALSGALITLSSDVFGRNEVATANGLTgMSAWLASTLFA-LVVGALADTIGFSPL 393
Cdd:cd17353 293 MFLLPFIGSVAVLFVlgvALIGFCYGGGFALFPALTADFFGTKNAGTNYGLL-YTAKGVGGLIGpIIAAYVLYTGGYNAA 371
|
410
....*....|....*...
gi 56480256 394 FAVLAVFDLLGALVIWTV 411
Cdd:cd17353 372 FIIAAALSLVALALALLL 389
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
9-364 |
1.96e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 62.37 E-value: 1.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 9 WYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVF 88
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 89 CGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFI 168
Cdd:TIGR00895 96 TLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 169 ISGALSFIWA---MAWL----IFYKHPRDQKHLTDEERDYIINGQEAQHQVSTAKkmSVGQILRnrqfwGIALPRFLAEP 241
Cdd:TIGR00895 176 VGGIAPLLLLlllMRFLpesiDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQK--STQGTKR-----SVFKALFQGKT 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 242 AWGTFNAWIPLFM--FKVYGFNlkeiamfAWMPMLFADLGCILGGYLPPLFQRWFGV---NLIVSRKMVVTLGAVLMIGP 316
Cdd:TIGR00895 249 ARITVLLWLLYFMllVGVYFLT-------NWLPKLMVELGFSLSLAATGGALFNFGGvigSIIFGWLADRLGPRVTALLL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 56480256 317 GMIGLF--------TNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANG 364
Cdd:TIGR00895 322 LLGAVFavlvgstlFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVG 377
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
15-409 |
3.92e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.07 E-value: 3.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 15 VTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATAL 94
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 95 AGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALS 174
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 175 FI-WAMAWLIFYKHPRdqkhltdeerdyiingqeaqHQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLF 253
Cdd:cd17489 161 LLaLLLVFLVKDPPPV--------------------AAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 254 MFKVygfNLKEIAMFawmpMLFADLGCILGGYLPPLFQRWFGvnlivsRKMVVTLGAVLM-IGPGMIGLFTNPYVAIMLL 332
Cdd:cd17489 221 AAER---GISNAGLF----FTVYAIALLLSRPFSGKLSDRKG------PKTVIIPGLLLLaLGLLLLSFAGSPWMLLLAA 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56480256 333 CIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17489 288 VLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
225-424 |
9.10e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 59.89 E-value: 9.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 225 RNRQFWGIALPRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFQRwfgvnlivsRKM 304
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLA-EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGP---------RRV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 305 VVTLGAVLMIGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGAL 384
Cdd:COG2223 73 LLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL 152
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 56480256 385 ADTIGFSPLFAVLAVFDLLGALVIWTVLQNKPAIEVAQET 424
Cdd:COG2223 153 IAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK 192
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
38-410 |
2.51e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 58.78 E-value: 2.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 38 EELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAVARGAVGAAEAAMIP 117
Cdd:cd17329 28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 118 AGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWaIVMHSWQMAFIIsGALSFIWAMAWLIFYKHPRDQKHLTDE 197
Cdd:cd17329 108 ASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGL-LLLYSFRLLFLA-AAVLFLLAALVLLFLLPETRPKRRAAE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 198 ErdyiingqeaqhqvsTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKeiaMFAWMPMLFAD 277
Cdd:cd17329 186 K---------------TEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES---LLGLLLALNAL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 278 LGCILGGYLPPLFQRWfgvnlivSRKMVVTLGAVLM-IGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGR 356
Cdd:cd17329 248 LIVLLQFPVARLVERF-------RLRKILMIGILLFaIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPP 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 56480256 357 NEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIWT 410
Cdd:cd17329 321 DKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
15-176 |
2.71e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 58.74 E-value: 2.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 15 VTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATAL 94
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 95 AGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIIS---G 171
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINlpiG 160
|
....*
gi 56480256 172 ALSFI 176
Cdd:cd17503 161 ILALL 165
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
7-185 |
1.16e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.43 E-value: 1.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 7 LRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEEL-NISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLW 85
Cdd:cd17325 196 LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 86 AVFCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQM 165
Cdd:cd17325 276 AVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT 355
|
170 180
....*....|....*....|
gi 56480256 166 AFIISGALSFIWAMAWLIFY 185
Cdd:cd17325 356 PFLAAAALLLLAAVLFLLLR 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-189 |
2.89e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 55.26 E-value: 2.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 9 WYMIALVTLGTVLGYLTRNTVAAAAPT-LMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLG--TKIGYAMFAVLW 85
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 86 AVFCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQM 165
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|....
gi 56480256 166 AFIISGALSFIWAMAWLIFYKHPR 189
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-409 |
3.16e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 55.30 E-value: 3.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELNisTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIG----YAMFAVLWAV 87
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFS--LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGrkkaLILTLLLFGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 88 FCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPpLVVWAIVMH-----S 162
Cdd:cd17316 79 ATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAA-LVASLLIPLlsgdwG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 163 WQMAFIISGALSFIwamAWLIFykhprdqkhltdeerdyiingqeaqhqvstakkmsvgqilrnRQFWGIALPRFLAEPA 242
Cdd:cd17316 158 WRILFLIGALPALL---ALLLR------------------------------------------RRTLLLILLWFFISFG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 243 WGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFQRwfgvnlivsRKMVVT--LGAVLMIGPGMIG 320
Cdd:cd17316 193 YYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR---------KKTLVIglILSGILALPLFYL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 321 LFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVF 400
Cdd:cd17316 264 LSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILAL 343
|
....*....
gi 56480256 401 DLLGALVIW 409
Cdd:cd17316 344 LAIVALIVA 352
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-176 |
3.49e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 54.87 E-value: 3.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 15 VTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATAL 94
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 95 AGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALS 174
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
..
gi 56480256 175 FI 176
Cdd:cd17321 161 LV 162
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
9-408 |
1.22e-07 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 53.40 E-value: 1.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 9 WYMIALVTLGTVLGYLTRNTVAaaaPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIG----------- 77
Cdd:cd17313 1 LFLLGFGFFGIEFGWALENSYV---PPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGrrrpfilvgap 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 78 ---YAMFAVLWA-VFCGATALAGSWGGLAVARGAVGAAE--AAMIPAGLKA-SSEWFPAKERSIAVGYFN--------VG 142
Cdd:cd17313 78 laaLGLILIPNAaDIGLALGDGPRTWALVLFVLGIVLLDfaMNVCQGPVRAlLPDLVPPEQRSKANGIINfmgglggvLG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 143 SSIGAMIAPPLVVWAIVMHSWQMAFIIsGALSFIWAMAWLIFYKHPRDQKHLTDEERDYIINGQEAQHQVSTAKKMsvgq 222
Cdd:cd17313 158 YLLGAILWDHNWFGFALGGNLKVPFYI-GAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSLLKLLKIM---- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 223 ilrNRQFWGIALPRFLAEPAWGTFNAWIPLFM-FKVYGFNLKEIA-------MFAWMPMLFAdLGCILGGYLPPLFQRWF 294
Cdd:cd17313 233 ---PRSLLRLLLVIFFWWIAFFPFELFFTDYMgEEVYHGTSAASShygagvrMGAWGLLIFS-LAFLIFSLPIGKLGKKI 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 295 GvnlivsRKMVVTLGAVLM-IGPGMIGLFTNPYVAIMLLCIGG---FAHQALSGALITLSSDVFGRNEvATANGLTGMSA 370
Cdd:cd17313 309 G------RKKVYLIGLVLFaVGMALMALVHNVTVALVLFALGGigwATININPYPLVSDYHSESGRGQ-GTDTGLLNLAI 381
|
410 420 430
....*....|....*....|....*....|....*...
gi 56480256 371 WLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVI 408
Cdd:cd17313 382 SLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGA 419
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
130-409 |
1.38e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 53.37 E-value: 1.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 130 KERSIAVGYFNVGSSIGAMIAPPLVVWAIVM------HSWQMAFIISGALSFIwAMAWLIFYKHPRDQkhltdeerdyii 203
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaaLGYRLTALIFAVLGLL-AFLLTFFGTKERPV------------ 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 204 ngqEAQHQVSTAKkmSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLkeiAMFAWMPMLFAdLGCILG 283
Cdd:COG2211 210 ---PEEEKVSLKE--SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSA---ALVGLLLALYF-LAALLG 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 284 GYLPPLFQRWFGvnlivsRKMVVTLGAVLMIGpGMIGLF----TNPYVAIMLLCIGGFAHQALSGALITLSSDV------ 353
Cdd:COG2211 281 APLWPRLAKRFG------KKKAFIIGLLLAAL-GLLLLFflgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydew 353
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56480256 354 -FGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSP---------------LFAVLAVFDLLGALVIW 409
Cdd:COG2211 354 kTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAgaaqspsaltgirllFFLLPAVLLLLAALLLL 425
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
127-409 |
1.58e-07 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 53.00 E-value: 1.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 127 FPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIisgALSFIWAMAWLIFYKHPRDQKHltdeerdyiinGQ 206
Cdd:cd17485 121 LTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSLLL---SLAALYLLLLLPVLFLRELELP-----------QQ 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 207 EAQHQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKvYGFNLKEIAM-FAWMPMLFADLGCILGGY 285
Cdd:cd17485 187 PPASERGAALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVD-RGFSLSQIGLlSGVGGSLVSIAGSLLGGY 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 286 LpplFQRWFGVNLIVSRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGL 365
Cdd:cd17485 266 L---LKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNWVLLLASLALLHLVGGMITTALFTLMMDCSQQAQAGTDYTL 342
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 56480256 366 TGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17485 343 LATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-182 |
1.92e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.60 E-value: 1.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 9 WYMIALVTLGTVLGYLTRNTVAAAAPTLMEE-LNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAV 87
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 88 FCGATALAGSWGGLAVARGAVGAAEAAMIPAGL--KASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIV-MHSWQ 164
Cdd:cd17316 256 LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGAlyAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAsTGGTG 335
|
170
....*....|....*...
gi 56480256 165 MAFIISGALSFIWAMAWL 182
Cdd:cd17316 336 VPALILALLAIVALIVAL 353
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
218-412 |
3.02e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.90 E-value: 3.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 218 MSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFQRwfgvn 297
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIA-ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGR----- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 298 livsRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLF 377
Cdd:COG2814 75 ----RRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG 150
|
170 180 190
....*....|....*....|....*....|....*
gi 56480256 378 ALVVGALADTIGFSPLFAVLAVFDLLGALVIWTVL 412
Cdd:COG2814 151 PLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
27-391 |
7.37e-07 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 50.93 E-value: 7.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 27 NTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGG--LAVA 104
Cdd:cd17381 47 SSPSVEHNETGKKYDWDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAgyLIAV 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 105 RGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIWAMAWLIF 184
Cdd:cd17381 127 RALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 185 YkhprdqkhltdeerdyiingqeaqhqvstakkmsvgqilrnRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKE 264
Cdd:cd17381 207 V-----------------------------------------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 265 IAMFAWMPMLFADLGCILGGYLPPLFQRWFGVNLIVSRKMVVTLG----AVLMIGPGMIGlfTNPYVAIMLLCIggfahq 340
Cdd:cd17381 246 NGFLSALPYLGCWLFMILSGQIADNLREKQNFSTVCVRKIFTLIGmigpAVFLLAAGFTG--CNYSLAVAFLTI------ 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 56480256 341 alSGALITLSSDVFGRNEVATANGLTGMSAWLASTlFALVVGALADTIGFS 391
Cdd:cd17381 318 --SSTLGGFSASGFNINHLDIAPSYAGILLGITNT-FATIPGMVGPVIAKS 365
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
34-408 |
7.65e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 50.76 E-value: 7.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 34 PTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAVARGAVGAAEA 113
Cdd:cd17371 23 PALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 114 AMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIA----PPLVVWAIVMHSWQMAFIISGALSFIwamAWLIfykhpr 189
Cdd:cd17371 103 GEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLAtllaALLFPLLPPEIAWRVLFLLGALPALL---VLFI------ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 190 dQKHLTDEERdyiinGQEAQHQVSTAKKMSVGQILRNRQFWGIALPRFL----AEPAWGTFNAWIPLFMFKVYGFNLKEI 265
Cdd:cd17371 174 -RRFVKEPPQ-----WQAARAARRHFADRPSLRELFSPPLLRTTLLASLlatgALGGYYGITTWLPSYLTGERGLSFEGS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 266 AMFAWMPMLFADLGCILGGYLPPLFqrwfgvnlivSRKMVVTLGAVL--MIGPGMIGLFTNPYVAIMLLCIGGFAHQALS 343
Cdd:cd17371 248 AGYLVVTILGGFLGYLAGGFLADRI----------GRRNNFALFALGsaISILLYFFLPLSPTLILILGFPLGFFASGPF 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56480256 344 GALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVI 408
Cdd:cd17371 318 SGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVL 382
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
10-386 |
1.09e-06 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 50.82 E-value: 1.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 10 YMIALVTLGTVlgYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTK-------------- 75
Cdd:PRK09556 31 YLVVFIGYLTM--YLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKqflpfllilsaicm 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 76 --IGYAMFAV-----LWAVFCGATALAGSWGGlavargavgaaeaamiPAGLKASSEWFPAKERSIAVGYFNVGSSIGAM 148
Cdd:PRK09556 109 lgFGASLGSGsvslgLMIALWALSGFFQSTGG----------------PCSYSTITRWTPRRKRGRFLGFWNISHNLGGA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 149 IAPPLVVW-AIVMHSWQMA--FIISGALSFIWAMaWLIFYKHprdqkhltDEERDYIINGQE--------AQHQVSTAKK 217
Cdd:PRK09556 173 GAGGVALWgANYFFDGHVIgmFIFPSIIALIIGF-IGLRYGS--------DSPEELGWGKAEeifgepisEEDKETESTD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 218 MSVGQI-----LRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNlKEIAMfaWMPMLF---ADLGCILGGYLPpl 289
Cdd:PRK09556 244 MTKWQIfveyvLKNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFS-KEDAI--NTFTLFeigALVGSLLWGWLS-- 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 290 fqrwfgvNLIVSRKMVVTLGAVLMIGpGMIGLF---TNPYVAIMLLCIGG---FAHQALSG-ALITLSSdvfgRNEVATA 362
Cdd:PRK09556 319 -------DLANGRRALVACIALALII-FTLGVYqhaTSEYMYLASLFALGflvFGPQLLIGvAAVGFVP----KKAIGVA 386
|
410 420
....*....|....*....|....*
gi 56480256 363 NGLTGMSAWLASTLFALV-VGALAD 386
Cdd:PRK09556 387 NGIKGTFAYLFGDSFAKVgLGMIAD 411
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
15-409 |
1.78e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 49.48 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 15 VTLGTVLGYLTRNTVAAAAPTLMEELNiSTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATAL 94
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 95 AGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAmIAPPLVVWAIVMH-SWQMAFIISgaL 173
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIAS-VAGPLIGGAFTDHlSWRWCFYIN--L 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 174 SFIWAMAWLIfykhprdqkhltdeerdyiingqeaqhqvstakkmsvgqilrnRQFWGIALPRFLAEPAWGTFNAWIPLF 253
Cdd:cd17502 157 PIGGLALALL-------------------------------------------RTILLSSIFGFLFGGALFGLIYYLPLY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 254 MFKVYGFNLKEIAMFAWMPMLFADLGCILGGYlppLFQRWFGV-NLIVSRKMVVTLGAVLMIgpgMIGLFTNPYVAIMLL 332
Cdd:cd17502 194 FQLVLGDSATKSGVRLLPLIIGLVIGSIISGA---LISKTGRYkPLIVIGTILMSVGAGLLT---TLTLDTSKWLLIGYL 267
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56480256 333 CIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFalvvgaladtIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17502 268 ILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLG----------VAITDVFLVALALAALAFLLSL 334
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
237-409 |
5.85e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.18 E-value: 5.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 237 FLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLpplfqrwfgVNLIVSRKMVVTLGAVLMIGP 316
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRL---------SDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 317 GMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAV 396
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170
....*....|...
gi 56480256 397 LAVFDLLGALVIW 409
Cdd:pfam07690 157 LAILSLLAAVLLL 169
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
24-356 |
9.59e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 47.32 E-value: 9.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 24 LTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAV 103
Cdd:cd17333 10 LTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 104 ARGAVGAAEAAMIPAG---LKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIvmhSWQMAFIISGALSFIWAMA 180
Cdd:cd17333 90 LMFLAGLGAGILDTGAntfVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSEL---SWSWAYLIIGLIYLLLAIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 181 WLIFYKHPRDQKHLTDeerdyiingqeaqhQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGF 260
Cdd:cd17333 167 ILLTLFPELPSARNPQ--------------QSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 261 NLKEIAMFAWMPMLFADLGCILGGYLpplfqrwfgVNLIVSRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLCIGGFAHQ 340
Cdd:cd17333 233 SDGLAGYLLSGFWVGITIGRLLGGPI---------SRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMA 303
|
330
....*....|....*.
gi 56480256 341 ALSGALITLSSDVFGR 356
Cdd:cd17333 304 ALFPTILSLGISNLPY 319
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
12-176 |
1.25e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 47.18 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGA 91
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 92 TALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISG 171
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
....*
gi 56480256 172 ALSFI 176
Cdd:cd17323 161 IISGF 165
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
29-173 |
1.40e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.81 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 29 VAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAVARGAV 108
Cdd:cd17365 18 MGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLT 97
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56480256 109 GAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGAL 173
Cdd:cd17365 98 GLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVP 162
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
130-392 |
2.10e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 46.44 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 130 KERSIAVGYFNVGSSIGAMI----APPLVVWA---IVMHSWQMAFIISGALSFIWAmawLIFYkhprdqkhLTDEERDYI 202
Cdd:cd17332 132 EERTSLTSWRMFFATIGGLLvtvlPPPLVAYFgggNASRGYFLTALIIGIIGIILL---LICF--------FGTRERVVP 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 203 INGQEAQHQVSTakkmSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFmfkvYGFNLKEIAMFAWMPMLFAdLGCIL 282
Cdd:cd17332 201 PEEEKSKLPLLK----SLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYY----FKYVLGGRAELVLLLLLIL-SGALL 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 283 GGYLPPLFQRWFGvnlivsRKMVVTLGAVLMIgPGMIGLF----TNPYVAIMLLCIGGFAHQALSGALITLSSDV----- 353
Cdd:cd17332 272 ALLPWPPLKKRFG------KKKAFFIGLLLAI-LGLLLLFflppGNLVLILVLAVLAGIGYGGANLLPWAMLADVidyge 344
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 56480256 354 --FGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSP 392
Cdd:cd17332 345 lkTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVA 385
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
8-186 |
2.89e-05 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 46.17 E-value: 2.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGY--------- 78
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFssglvlsgl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 79 -----------AMFAVLWavFCGATALAGSWgglavargavgaaeaamiPAGLKASSEWFPAKERSIAVGYFNVGSSIGA 147
Cdd:cd17343 81 ttvafsgsssvWVFSILW--FLNGLAQGLGW------------------PPCAKILRKWFSPSQFGTWWSVLSTSMNLAG 140
|
170 180 190
....*....|....*....|....*....|....*....
gi 56480256 148 MIAPPLVVWAIVMHSWQMAFIISGALSFIWAMAWLIFYK 186
Cdd:cd17343 141 SLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIK 179
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
32-410 |
3.29e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.68 E-value: 3.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 32 AAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTK----IGYAMFAVLWAVFCGATALAG-SWGGLAVARG 106
Cdd:cd06173 21 ALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrlliLADLLRALLAAVLALLALLGSlSLWLLLVLAF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 107 AVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFI-WAMAWLIFY 185
Cdd:cd06173 101 LLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLsALLLLFIRR 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 186 KHPRDQKHLTDEERDYIINGqeaqhqvstakkmsVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLkei 265
Cdd:cd06173 181 PPPAAPGESSSLLLRDLREG--------------LRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGA--- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 266 AMFAWMPMLFAdLGCILGGYLPPLFQRWFGvnlivSRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLCIGGFAHQALSGA 345
Cdd:cd06173 244 AGYGLLLAAFG-VGALLGALLLGRLSKRRR-----RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVP 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56480256 346 LITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIWT 410
Cdd:cd06173 318 LNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
8-407 |
8.77e-05 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 44.32 E-value: 8.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLwaV 87
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIM--V 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 88 FCGATALAGSWGGLAVARGAVGAAEA---AMIPAGLKASSEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQ 164
Cdd:cd17314 79 LAGYTYLSYVFNSFPLSYACFVFIGAgtgILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVFYGLA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 165 MAFIISGALsfIWAMAWLIFYKHPRDQKHLTdeerdyiingqeAQHQVSTAKKMSVGQILRNRQFWGIALPRFLaepawg 244
Cdd:cd17314 158 LVYTILGIL--AAIVLSVVSLLGFKEPPDNQ------------ARLHVQKKKTQTMGEIFRDKVFWILFIAIFL------ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 245 TFNAWIPLFMFKV-YGFNLKEIAMFAWMPML-FADLGCILGGYLPPLFQRWFGVNLivsRKMVVTLG-AVLMIGPGMIGL 321
Cdd:cd17314 218 VLIGGFLFIANMAsLVRSLQLDAPSFVTKLMsIYGLFNAFGRLLWGIVADFFGGRL---STLSILLTiLGLGLCAFLFLL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 322 FTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALAD-TIGFSPLFAVLAVF 400
Cdd:cd17314 295 KMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDrTPSYISAVYIYAVI 374
|
....*..
gi 56480256 401 DLLGALV 407
Cdd:cd17314 375 VFLASAI 381
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
8-406 |
1.19e-04 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 43.93 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLD----------------- 70
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDrsnpryfmgigliatgi 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 71 ---VLGTKIGYAMFAVLWavfcGATALAGSWGglavargavgaaeaamIPAGLKASSEWFPAKERSIAVGYFNVGSSIGA 147
Cdd:cd17488 81 iniLFGFSSSLWAFAVLW----TLNAFFQGWG----------------WPPCARLLTHWYSRNERGFWWSIWNTSHNIGG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 148 MIAPPLVVWAIVMHSWQMAFIISGALSFIWAMaWLIFykhprdqkHLTDeerdyiingqeaqhqvstakkmsvgqilRNR 227
Cdd:cd17488 141 ALIPILTGFAALTYGWRAGMYVPGIIAILMGI-VLCW--------RLRD----------------------------RPP 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 228 QFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLF---QRWfGVNLIVSRKM 304
Cdd:cd17488 184 YIWLLAFCYVLVYVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLfkgNRG-PMNLIFALGL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 305 VVTLGAVLMIGPGMIGLftnpyVAIMLLCIGGFAHQalSGALITLSSDVFGRNEVA-TANGLTGMSAWLASTLFALVVGA 383
Cdd:cd17488 263 LVSVGALWLVPVHSYWL-----LATCFFTIGFFVFG--PQMLIGMAAAECSHKDAAgSATGFVGLFAYLGAALAGYPLAK 335
|
410 420
....*....|....*....|...
gi 56480256 384 LADTIGFSPLFAVLAVFDLLGAL 406
Cdd:cd17488 336 VIESWGWSGFFIVISIAAAISGL 358
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
36-191 |
1.32e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.07 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 36 LMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAVARGAVGAAEAAM 115
Cdd:COG0738 237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM 316
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56480256 116 IPAGLKASSEWFPaKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIWAMAWLIFYKHPRDQ 191
Cdd:COG0738 317 FPTIFSLALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
23-411 |
1.37e-04 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 43.80 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 23 YLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLD-VLGTKIG---YAMFAVLWAVFCGATALAGSW 98
Cdd:cd17340 12 YFCYDNPAALQKQFIEDMDINTSQFMLLYSVYSWPNVVLCFFGGFLIDrVFGIRLGtiiFSLLVLIGQLIFALGALTNLF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 99 GGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIA----VGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF------- 167
Cdd:cd17340 92 WLMLVGRFIFGIGGESLAVAQNTYAVSWFKGKELNLVfglqLSFARIGSTVNFNVMPPIYKRISDFYSGYKSLgvalwig 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 168 IISGALSFIWAMAWLIFYKHPRDQKHltdeeRDYIINGQEAqhQVSTAKKMSVgqilrnrQFWGIALPRFLAEPAWGTFN 247
Cdd:cd17340 172 AITCLFSLICAIILGLLDKRAERILK-----KESNKTGEVI--KLSDVKDFPL-------SFWLICIICVFYYVAVFPFI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 248 AWIPLFMFKVYGFNLKEIAmfAWMPMLFadlgcILGGYLPPLFQrwFGVNLIVSRKMVVTLGAVLMIGPGMIGLFT--NP 325
Cdd:cd17340 238 GLGTVFFEEKYGFSPSEAA--AVNSIVY-----IISAAASPVFG--FLVDKVGRNILWVLIALVITLLGHLLLAFTfvNP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 326 YVAImllCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPL---FAVLAVFDL 402
Cdd:cd17340 309 LIAM---VIMGIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDKKGYLLLevfFIACLCVSL 385
|
....*....
gi 56480256 403 LGALVIWTV 411
Cdd:cd17340 386 IALIILYLV 394
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
300-423 |
8.07e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.41 E-value: 8.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 300 VSRKMVVTLGAVLM-IGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFA 378
Cdd:cd17325 58 FGRKRLLLLGLLLLaVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGP 137
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 56480256 379 LVVGALADTIGFSPLFAVLAVFDLLGALVIWTVLQNKPAIEVAQE 423
Cdd:cd17325 138 LLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRA 182
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
3-184 |
1.72e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 3 KIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNI-STQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMF 81
Cdd:cd17473 190 TAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 82 AVLWAVFCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM- 160
Cdd:cd17473 270 FALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLt 349
|
170 180
....*....|....*....|....
gi 56480256 161 HSWQMAFIISGALSFIWAMAWLIF 184
Cdd:cd17473 350 GGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
300-412 |
1.72e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 300 VSRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLCIG-GFAHQALSGALITLSSDVFGRNEVATANGLTgMSAWLASTLFA 378
Cdd:cd17324 61 IERRRLLLVLLLLFILGNLLAALAPSFALLLLARALaGLAHGGFWAIAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLG 139
|
90 100 110
....*....|....*....|....*....|....*
gi 56480256 379 LVVGA-LADTIGFSPLFAVLAVFDLLGALVIWTVL 412
Cdd:cd17324 140 RPLGGlLGQLLGWRAAFLAIAVLALLAALLLWRLL 174
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
302-423 |
2.44e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.88 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 302 RKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVV 381
Cdd:cd17489 61 KRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALG 140
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 56480256 382 GALADTIGFSPLFAVLAVFDLLGALVIWTVLQNKPAIEVAQE 423
Cdd:cd17489 141 LFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAE 182
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
34-408 |
2.92e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.46 E-value: 2.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 34 PTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVfcgATALAGSWGGLAVARGAVGAAEA 113
Cdd:cd17477 20 SLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAV---SVLLLALTDSPWVWFLLRFVMGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 114 AMipAGLKASSE-WF----PAKERSIAVGYFNVGSSIGAMIAPPLVvwAIVMHSWQMAFIISGALSFIwamAWLIFYKHP 188
Cdd:cd17477 97 GL--AGLFVVSEsWLnalaTNENRGRVLGLYSTVLGLGFALGPLLL--ALVGTAGALPFLIAAVLLLL---ALVPLLLTR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 189 RDQKHLTDEErdyiingqeaqhqvstakKMSVGQILRnrQFWGIALPRFLAEPAWGTFNAWIPLFMFKVyGFNLKEIAMF 268
Cdd:cd17477 170 RAAPEIEEAE------------------SISLRRLLR--IAPLALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 269 AWMPMLFADLGCILGGYLPPLFQRwfgvnlivsRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLC--IGGFAHqALSGAL 346
Cdd:cd17477 229 LAAFVLGGLLLQWPLGWLADRFDR---------RRVLLGCALLGALAALLLPLVPGLPLALLVLLflWGGAAG-PLYTLA 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56480256 347 ITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVI 408
Cdd:cd17477 299 LALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
112-412 |
3.41e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 3.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 112 EAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIApPLVVWAIVMHSWQMAFIISGALSFIWAMAWLiFYKHPRDQ 191
Cdd:cd17473 102 VAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVF-LLLGGALAEIGWRAPFLVYLLALPVLILVLL-FLPEPARK 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 192 KHltdeerdyiingqeaqhqVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWM 271
Cdd:cd17473 180 SK------------------SAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAI 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 272 PMLFAdlgcILGGYLPPLFQRWFGvnlivsRKMVVTLGAVLM-IGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALITLS 350
Cdd:cd17473 242 ASLAG----AIGALLFGRLKRRLG------KRRLLAIGFALMaLGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWA 311
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56480256 351 SDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTI-GFSPLFAVLAVFDLLGALVIWTVL 412
Cdd:cd17473 312 MSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
34-411 |
3.47e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 39.51 E-value: 3.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 34 PTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAVARGAVGAAEA 113
Cdd:cd17331 24 PYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 114 amIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFI-WAMAWLIFYKHPRDQK 192
Cdd:cd17331 104 --MQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLsIVLVILLIPSNTKSKR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 193 HLTDEErdyiingqeaqhQVSTAKKMSVGQI---LRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFa 269
Cdd:cd17331 182 EKEAKE------------SASPPSVFNLKEIlrlLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYL- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 270 wMPMLFAdLGCILGGYLPPLFQRWFGvnlivSRKMVVTLGAVLMIG-PGMIGLFTNP-YVAIML-LCIGGFAHQALSGAL 346
Cdd:cd17331 249 -MSYAGV-LGMVVQGLLVGPLTKRFG-----ERSLLKLSVALLAIGyLLLAFVTTVWqLLVLLLpLVIGGSVLYTVITSL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56480256 347 ITLSSDvfgRNEVATANGLTGMSAWLASTLFALVVGALADTIGFsPLFAVLAVFDLLGALVIWTV 411
Cdd:cd17331 322 LTKAVP---PEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGF-PSFGLLGAAINGLLTVYLLL 382
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
35-286 |
5.68e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.82 E-value: 5.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 35 TLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAG-SWGGLAVARGAVGAAEA 113
Cdd:TIGR00886 27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVqSYSVLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 114 AMIPAgLKASSEWFPAKER----SIAVGYFNVGSSIGAMIAPPLVVWAI------VMHSWQMAFIISGALsFIWAMAWLI 183
Cdd:TIGR00886 107 SFASC-MPWISFFFPKKIQgtalGLAAGWGNMGGGVAQFVMPPIIGSLIfgggqpAHLAWGWAFVIVPAG-ILLLPALLI 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 184 FY---KHPRDQKhltdeerdyiingqeaqhQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGF 260
Cdd:TIGR00886 185 FFvgaDTPPGKP------------------ATGKLSFKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGL 246
|
250 260
....*....|....*....|....*.
gi 56480256 261 NLKEIAMFAWMPMLFADLGCILGGYL 286
Cdd:TIGR00886 247 SKVQAGAYASLGGFLGSLARPAGGAI 272
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
34-183 |
6.54e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.69 E-value: 6.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 34 PTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWA--VFCGATALAGSWGGLAVARGAVGAA 111
Cdd:cd17352 207 PSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLIlgLSLLAFPLATTYVGLIVFSVLFGFC 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56480256 112 EAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM-HSWQMAFIISGALSFIWAMAWLI 183
Cdd:cd17352 287 SGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYtGDYDAAFYFCGACLLLSGVLLFL 359
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
237-431 |
8.32e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.18 E-value: 8.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 237 FLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCILGGYLpplfqrwfgVNLIVSRKMVVTLGAVLMIGP 316
Cdd:cd06174 6 FLTGLARGLISPLLPALL-QSFGLSASQLGLLFALFSLGYALLQPLAGLL---------ADRFGRRPVLLLGLLLFALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 317 GMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALAD--TIGFSPLF 394
Cdd:cd06174 76 LLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVF 155
|
170 180 190
....*....|....*....|....*....|....*..
gi 56480256 395 AVLAVFDLLGALVIWTVLQNKPAIEVAQETHNDPAPQ 431
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESARAKNEEASSKSV 192
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
7-262 |
8.82e-03 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 38.15 E-value: 8.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 7 LRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEElNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKI----GYAMFA 82
Cdd:PRK11273 26 LRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVflpaGLILAA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 83 VLWAVFCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM-H 161
Cdd:PRK11273 105 AVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLFLLGMAWfN 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 162 SWQMAFIISGALSFIWAM-AWLIFYKHPRDQKHLTDEE--RDYIINGQEAQHQVSTAKKMSVGQILRNRQFWGIALPR-F 237
Cdd:PRK11273 185 DWHAALYMPAFAAILVALfAFAMMRDTPQSCGLPPIEEykNDYPDDYNEKHEQELTAKQIFMQYVLPNKLLWYIAIANvF 264
|
250 260
....*....|....*....|....*
gi 56480256 238 LAEPAWGTFNaWIPLFMFKVYGFNL 262
Cdd:PRK11273 265 VYLLRYGILD-WSPTYLKEVKHFAL 288
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
32-169 |
9.59e-03 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 38.17 E-value: 9.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56480256 32 AAPTLMEELNISTQQYSYIIAAYSaayTVMqpvAGYVLDV--LGTKIGYAMFAVLWAVFCG----ATALAGSWGGLAVAR 105
Cdd:PRK14995 28 AAPTLSMTLGASGNELLWIIDIYS---LVM---AGMVLPMgaLGDRIGFKRLLMLGGTLFGlaslAAAFSPTASWLIATR 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56480256 106 GAVGAAEAAMIPAGLKASSEWF-PAKERSIAVGYFNVGSSIGAMIApPLVVWAIVMH-SWQMAFII 169
Cdd:PRK14995 102 ALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFG-PLVGGILLEHfYWGSVFLI 166
|
|
| |
