NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1677531282|ref|NP_689653|]
View 

KICSTOR subunit 2 isoform 2 [Homo sapiens]

Protein Classification

DUF2003 domain-containing protein( domain architecture ID 10559425)

DUF2003 domain-containing protein similar to Homo sapiens KICSTOR complex protein C12orf66, part of the KICSTOR complex that functions in the amino acid-sensing branch of the TORC1 signaling pathway

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
C12orf66_like pfam09404
KICSTOR complex C12orf66 like; This entry includes C12orf66-like proteins. Human C12orf66 is ...
 10-444 0e+00

KICSTOR complex C12orf66 like; This entry includes C12orf66-like proteins. Human C12orf66 is part of the KICSTOR complex that functions in the amino acid-sensing branch of the TORC1 signaling pathway.


:

Pssm-ID: 401380  Cd Length: 440  Bit Score: 782.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282  10 PVPVEQAVLETFFSHLGIFSYDKAKDNVEKEREANKSAGGSWLSLLAALAHLAAAEKVYHSLTYLGQKLGGQSFFSRKDS 89
Cdd:pfam09404   5 PVPQERAILETFFHALGQFAFDKAKDYVEKERDSRKSAGSIWVSLLAALAHLAAAEKIYHSLTFLGQKLGGQSFFSRKDS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282  90 IRTIYTSLHNELKKVV-TGRGALGGTAPHVEELLSHLSEQLCFFVQARMEIADFYEKMYTLSTQKFINAEELVGLLDAIM 168
Cdd:pfam09404  85 IRTIYTSLLNELKKVVeMGRVAPGGTAPVLEELLAHLSEQLCHFVQARMEIADFYEKMHSLGSQKVINYEELVITLDAIL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282 169 KKYSSRFHHPILSPLESSFQLEVDVLCHLLKAQAQVSEWKFLPSLVNLHSAHTKLQTWGQIFEKQRETKKHLFGGQSQKA 248
Cdd:pfam09404 165 HKYSSRFHHPILSPLESSFQFEVDVLTHLLRAQAQMSEWKFLPSLLHLHGAHSKLTSWGQLFQRQKETRKHLFGGQSQKA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282 249 VQPPHLFLWLMKLKNMLLAKFSFYFHEALSRQTTASEMKTLTAKANPDFFGKISSFIRKYDAANVSLIFDNRGSESFQGH 328
Cdd:pfam09404 245 VQPPHLYLWLQKLKAALLAKFSFYFHEALSRQTTPAEMKTLTARTSPDYFGKISSFIRKSDASNVSLVFDNRGSESFQGH 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282 329 GYHHPHSYREAPKGVDQYPAVVSLPSDRPVMHWPNVIMIMTDRTSDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVIIF 408
Cdd:pfam09404 325 GYHHPQSYREAPKGVDQFPAVVSLPGERPLTHWPNVIMIMMDRAADLNTLEKVVHFYDDKVQSTYFLTRPEPHFTLVVIF 404

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1677531282 409 ESKKSERDSHFISFLNEVSLALKNPKVFASLKPGAK 444
Cdd:pfam09404 405 ESKKSEKDSYITSFLQEIALSLRNSKVFASLKPGSK 440
 
Name Accession Description Interval E-value
C12orf66_like pfam09404
KICSTOR complex C12orf66 like; This entry includes C12orf66-like proteins. Human C12orf66 is ...
 10-444 0e+00

KICSTOR complex C12orf66 like; This entry includes C12orf66-like proteins. Human C12orf66 is part of the KICSTOR complex that functions in the amino acid-sensing branch of the TORC1 signaling pathway.


Pssm-ID: 401380  Cd Length: 440  Bit Score: 782.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282  10 PVPVEQAVLETFFSHLGIFSYDKAKDNVEKEREANKSAGGSWLSLLAALAHLAAAEKVYHSLTYLGQKLGGQSFFSRKDS 89
Cdd:pfam09404   5 PVPQERAILETFFHALGQFAFDKAKDYVEKERDSRKSAGSIWVSLLAALAHLAAAEKIYHSLTFLGQKLGGQSFFSRKDS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282  90 IRTIYTSLHNELKKVV-TGRGALGGTAPHVEELLSHLSEQLCFFVQARMEIADFYEKMYTLSTQKFINAEELVGLLDAIM 168
Cdd:pfam09404  85 IRTIYTSLLNELKKVVeMGRVAPGGTAPVLEELLAHLSEQLCHFVQARMEIADFYEKMHSLGSQKVINYEELVITLDAIL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282 169 KKYSSRFHHPILSPLESSFQLEVDVLCHLLKAQAQVSEWKFLPSLVNLHSAHTKLQTWGQIFEKQRETKKHLFGGQSQKA 248
Cdd:pfam09404 165 HKYSSRFHHPILSPLESSFQFEVDVLTHLLRAQAQMSEWKFLPSLLHLHGAHSKLTSWGQLFQRQKETRKHLFGGQSQKA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282 249 VQPPHLFLWLMKLKNMLLAKFSFYFHEALSRQTTASEMKTLTAKANPDFFGKISSFIRKYDAANVSLIFDNRGSESFQGH 328
Cdd:pfam09404 245 VQPPHLYLWLQKLKAALLAKFSFYFHEALSRQTTPAEMKTLTARTSPDYFGKISSFIRKSDASNVSLVFDNRGSESFQGH 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282 329 GYHHPHSYREAPKGVDQYPAVVSLPSDRPVMHWPNVIMIMTDRTSDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVIIF 408
Cdd:pfam09404 325 GYHHPQSYREAPKGVDQFPAVVSLPGERPLTHWPNVIMIMMDRAADLNTLEKVVHFYDDKVQSTYFLTRPEPHFTLVVIF 404

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1677531282 409 ESKKSERDSHFISFLNEVSLALKNPKVFASLKPGAK 444
Cdd:pfam09404 405 ESKKSEKDSYITSFLQEIALSLRNSKVFASLKPGSK 440
 
Name Accession Description Interval E-value
C12orf66_like pfam09404
KICSTOR complex C12orf66 like; This entry includes C12orf66-like proteins. Human C12orf66 is ...
 10-444 0e+00

KICSTOR complex C12orf66 like; This entry includes C12orf66-like proteins. Human C12orf66 is part of the KICSTOR complex that functions in the amino acid-sensing branch of the TORC1 signaling pathway.


Pssm-ID: 401380  Cd Length: 440  Bit Score: 782.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282  10 PVPVEQAVLETFFSHLGIFSYDKAKDNVEKEREANKSAGGSWLSLLAALAHLAAAEKVYHSLTYLGQKLGGQSFFSRKDS 89
Cdd:pfam09404   5 PVPQERAILETFFHALGQFAFDKAKDYVEKERDSRKSAGSIWVSLLAALAHLAAAEKIYHSLTFLGQKLGGQSFFSRKDS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282  90 IRTIYTSLHNELKKVV-TGRGALGGTAPHVEELLSHLSEQLCFFVQARMEIADFYEKMYTLSTQKFINAEELVGLLDAIM 168
Cdd:pfam09404  85 IRTIYTSLLNELKKVVeMGRVAPGGTAPVLEELLAHLSEQLCHFVQARMEIADFYEKMHSLGSQKVINYEELVITLDAIL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282 169 KKYSSRFHHPILSPLESSFQLEVDVLCHLLKAQAQVSEWKFLPSLVNLHSAHTKLQTWGQIFEKQRETKKHLFGGQSQKA 248
Cdd:pfam09404 165 HKYSSRFHHPILSPLESSFQFEVDVLTHLLRAQAQMSEWKFLPSLLHLHGAHSKLTSWGQLFQRQKETRKHLFGGQSQKA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282 249 VQPPHLFLWLMKLKNMLLAKFSFYFHEALSRQTTASEMKTLTAKANPDFFGKISSFIRKYDAANVSLIFDNRGSESFQGH 328
Cdd:pfam09404 245 VQPPHLYLWLQKLKAALLAKFSFYFHEALSRQTTPAEMKTLTARTSPDYFGKISSFIRKSDASNVSLVFDNRGSESFQGH 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531282 329 GYHHPHSYREAPKGVDQYPAVVSLPSDRPVMHWPNVIMIMTDRTSDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVIIF 408
Cdd:pfam09404 325 GYHHPQSYREAPKGVDQFPAVVSLPGERPLTHWPNVIMIMMDRAADLNTLEKVVHFYDDKVQSTYFLTRPEPHFTLVVIF 404

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1677531282 409 ESKKSERDSHFISFLNEVSLALKNPKVFASLKPGAK 444
Cdd:pfam09404 405 ESKKSEKDSYITSFLQEIALSLRNSKVFASLKPGSK 440
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH