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Conserved domains on  [gi|125719163|ref|NP_666472|]
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olfactory receptor 574 [Mus musculus]

Protein Classification

olfactory receptor family 51 protein( domain architecture ID 11607012)

olfactory receptor family 51 protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 39-312 1.02e-136

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320350  Cd Length: 275  Bit Score: 389.55  E-value: 1.02e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  39 WISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVH 118
Cdd:cd15222    2 WISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 119 GFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDII 198
Cdd:cd15222   82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 199 KYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLF 278
Cdd:cd15222  162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 125719163 279 SSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVI 312
Cdd:cd15222  242 KHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 39-312 1.02e-136

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 389.55  E-value: 1.02e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  39 WISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVH 118
Cdd:cd15222    2 WISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 119 GFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDII 198
Cdd:cd15222   82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 199 KYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLF 278
Cdd:cd15222  162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 125719163 279 SSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVI 312
Cdd:cd15222  242 KHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 45-320 1.99e-87

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 264.36  E-value: 1.99e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163   45 CGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLE 124
Cdd:pfam13853   2 CLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIME 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  125 SSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTN 204
Cdd:pfam13853  82 SAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCAD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  205 PWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLFSSTPRV 284
Cdd:pfam13853 162 IKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPL 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 125719163  285 ICSILGNMYLLLPPVLNPIIYSLKTKVIRQAIFQLF 320
Cdd:pfam13853 242 LQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
 39-307 6.39e-04

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 41.30  E-value: 6.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  39 WISIPVCGLYTIALLGNsIILFVIIIERSLHKPMYYFLSMLSVVDLgLTITTLPTVLGVLWFHAREISIKVCLIQMFFVH 118
Cdd:PHA03087  42 ILIVVYSTIFFFGLVGN-IIVIYVLTKTKIKTPMDIYLLNLAVSDL-LFVMTLPFQIYYYILFQWSFGEFACKIVSGLYY 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 119 GFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPsVMAVKSVSFQGGQELSHPFcfhpdii 198
Cdd:PHA03087 120 IGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTP-ILFVYTTKKDHETLICCMF------- 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 199 kytYTNPwiSSFWGMFLQLYLNGTDLLF----ILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVA 274
Cdd:PHA03087 192 ---YNNK--TMNWKLFINFEINIIGMLIpltiLLYCYSKILITLKGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFV 266

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 125719163 275 HRLFSSTPRVICSILGNMYLLLPPV---------LNPIIYSL 307
Cdd:PHA03087 267 YSLHILHFKSGCKAVKYIQYALHVTeiislshccINPLIYAF 308
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 39-312 1.02e-136

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 389.55  E-value: 1.02e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  39 WISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVH 118
Cdd:cd15222    2 WISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 119 GFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDII 198
Cdd:cd15222   82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 199 KYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLF 278
Cdd:cd15222  162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 125719163 279 SSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVI 312
Cdd:cd15222  242 KHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 38-312 2.39e-103

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 304.98  E-value: 2.39e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd15917    1 IWLSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDI 197
Cdd:cd15917   81 HSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 198 IKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRL 277
Cdd:cd15917  161 VKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125719163 278 FSSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVI 312
Cdd:cd15917  241 GHHVPPHVHILLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 38-312 6.44e-89

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 267.98  E-value: 6.44e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd15953    1 IWISIPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDI 197
Cdd:cd15953   81 HTLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 198 IKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRL 277
Cdd:cd15953  161 VKLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125719163 278 FSSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVI 312
Cdd:cd15953  241 GQGIAPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 38-312 1.20e-88

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 267.36  E-value: 1.20e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd15950    1 FWIAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDI 197
Cdd:cd15950   81 HSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 198 IKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRL 277
Cdd:cd15950  161 VKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125719163 278 FSSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVI 312
Cdd:cd15950  241 GQGVPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 45-320 1.99e-87

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 264.36  E-value: 1.99e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163   45 CGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLE 124
Cdd:pfam13853   2 CLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIME 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  125 SSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTN 204
Cdd:pfam13853  82 SAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCAD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  205 PWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLFSSTPRV 284
Cdd:pfam13853 162 IKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPL 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 125719163  285 ICSILGNMYLLLPPVLNPIIYSLKTKVIRQAIFQLF 320
Cdd:pfam13853 242 LQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 38-312 9.07e-87

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 262.61  E-value: 9.07e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd15221    1 VWISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDI 197
Cdd:cd15221   81 HFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 198 IKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRL 277
Cdd:cd15221  161 ARLACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125719163 278 FSSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVI 312
Cdd:cd15221  241 GRHIPRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 38-312 1.05e-86

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 262.28  E-value: 1.05e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd15951    1 VWISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDI 197
Cdd:cd15951   81 HSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 198 IKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRL 277
Cdd:cd15951  161 VKLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125719163 278 FSSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVI 312
Cdd:cd15951  241 GHNVPPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 37-313 8.54e-85

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 257.53  E-value: 8.54e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  37 HVWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFF 116
Cdd:cd15948    1 HPWISIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 117 VHGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPD 196
Cdd:cd15948   81 LHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 197 IIKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHR 276
Cdd:cd15948  161 VVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHR 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 125719163 277 LFSSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVIR 313
Cdd:cd15948  241 FARHVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 25-313 4.81e-83

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 253.55  E-value: 4.81e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  25 FLLTAFPGLELAHVWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHARE 104
Cdd:cd15949    4 FILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 105 ISIKVCLIQMFFVHGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGG 184
Cdd:cd15949   84 IPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 185 QELSHPFCFHPDIIKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIF 264
Cdd:cd15949  164 NIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAILAF 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 125719163 265 YVPMITLSVAHRLFSSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVIR 313
Cdd:cd15949  244 YVPIAVSSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 38-312 9.27e-82

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 249.60  E-value: 9.27e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd15952    1 FWIGFPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDI 197
Cdd:cd15952   81 HTFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 198 IKYTYTNPWISSFWGMFLQLYLnGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRL 277
Cdd:cd15952  161 AKLACASIRINIIYGLFAISVL-VLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRF 239

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125719163 278 FSSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVI 312
Cdd:cd15952  240 GHNIPRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 39-316 1.52e-78

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 241.81  E-value: 1.52e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  39 WISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVH 118
Cdd:cd15223    2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 119 GFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDII 198
Cdd:cd15223   82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 199 KYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLF 278
Cdd:cd15223  162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 125719163 279 SSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15223  242 KTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 38-312 1.59e-78

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 241.69  E-value: 1.59e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd15956    1 VWLSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDI 197
Cdd:cd15956   81 HAFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 198 IKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRL 277
Cdd:cd15956  161 VKLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125719163 278 FSSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVI 312
Cdd:cd15956  241 GHSVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 38-312 6.15e-70

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 219.69  E-value: 6.15e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd15954    1 IWISIPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDI 197
Cdd:cd15954   81 HTFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 198 IKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRL 277
Cdd:cd15954  161 VKLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 125719163 278 FS-STPRVICSILGNMYLLLPPVLNPIIYSLKTKVI 312
Cdd:cd15954  241 GGhHITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 38-312 6.81e-69

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 216.94  E-value: 6.81e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd15955    1 HWIGIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSV-SFQGGQELSHPFCFHPD 196
Cdd:cd15955   81 HTLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKLRlHHFRSTVISHSYCEHMA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 197 IIKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHR 276
Cdd:cd15955  161 VVKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHR 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 125719163 277 LFSSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVI 312
Cdd:cd15955  241 FGHHVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 38-308 3.26e-61

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 196.94  E-value: 3.26e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd13954    1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDI 197
Cdd:cd13954   81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 198 IKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRl 277
Cdd:cd13954  161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPS- 239

                        250       260       270
                 ....*....|....*....|....*....|.
gi 125719163 278 fSSTPRVICSILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd13954  240 -SSYSSDLDKVVSVFYTVVTPMLNPIIYSLR 269
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 47-316 5.27e-48

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 163.01  E-value: 5.27e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15225   10 IYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLT-------DMMSFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDIIK 199
Cdd:cd15225   90 LLAAMAYDRYVAICNPLRYTLIMNrrvclqlVAGSWLSGILVSLGQTTLIF-------SLPFCGSNEINHFFCDIPPVLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 200 YTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVpmiTLSVAH---- 275
Cdd:cd15225  163 LACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYG---CASFTYlrpk 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 125719163 276 -RLFSSTPRVIcSIlgnMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15225  240 sSYSPETDKLL-SL---FYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 48-316 2.11e-47

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 161.28  E-value: 2.11e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  48 YTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSV 127
Cdd:cd15231   11 YLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 128 LVAMAFDRYLAICSPLKYATFLTDMM-------SFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDIIKY 200
Cdd:cd15231   91 LAVMAYDRYVAICNPLHYAVIMSRKVclqlaaaSWLCGFLNSAVHTVLTF-------RLSFCGSNQISHFFCDIPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 201 TYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVahRLFSS 280
Cdd:cd15231  164 SCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYN--RPSSG 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 125719163 281 TPRVICSILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15231  242 YSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 47-316 4.66e-47

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 160.47  E-value: 4.66e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15235   11 MYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNPW 206
Cdd:cd15235   91 LLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTS 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 207 ISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMItlSVAHRLFSSTPRVIC 286
Cdd:cd15235  171 LNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTII--GVYFQPSSSYSADKD 248

                        250       260       270
                 ....*....|....*....|....*....|
gi 125719163 287 SILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15235  249 RVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 47-308 1.40e-45

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 156.46  E-value: 1.40e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15227   10 IYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTD-------MMSFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDIIK 199
Cdd:cd15227   90 LLTVMAYDRYVAICHPLHYEVIMNRgacvqmaAASWLSGLLYGALHTANTF-------SLPFCGSNVIHQFFCDIPQLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 200 YTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYvpmITLSVAH-RLF 278
Cdd:cd15227  163 LSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFL---STGSFAYlKPP 239

                        250       260       270
                 ....*....|....*....|....*....|
gi 125719163 279 SSTPRVICSILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15227  240 SDSPSLLDLLLSVFYSVVPPTLNPIIYSLR 269
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 47-316 2.61e-45

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 155.81  E-value: 2.61e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15234   10 MYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNPW 206
Cdd:cd15234   90 LLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDTL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 207 ISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFY----VPMITLSVAHrlfSSTP 282
Cdd:cd15234  170 INNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYgtglGVYISSAVTH---SSRK 246

                        250       260       270
                 ....*....|....*....|....*....|....
gi 125719163 283 RVICSIlgnMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15234  247 TAVASV---MYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 46-308 1.38e-43

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 151.23  E-value: 1.38e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15918    9 GMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFltdMMSFVIGLIICIRQVFFMFPSVM---AVKSVSFQGGQELSHPFCFHPDIIKYTY 202
Cdd:cd15918   89 FLLAVMAYDRYVAICHPLHYTTI---MSPRLCILLVAASWVITNLHSLLhtlLMARLSFCASNEIPHFFCDLNPLLKLSC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 203 TNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMItlSVAHRLFSSTP 282
Cdd:cd15918  166 SDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVI--GVYLSPPSSHS 243

                        250       260
                 ....*....|....*....|....*.
gi 125719163 283 RVICSILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15918  244 ASKDSVAAVMYTVVTPMLNPFIYSLR 269
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 48-308 1.84e-43

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 151.12  E-value: 1.84e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  48 YTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSV 127
Cdd:cd15230   11 YLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 128 LVAMAFDRYLAICSPLKYATFLTDM-------MSFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDIIKY 200
Cdd:cd15230   91 LAAMAYDRYVAICNPLLYTVIMSKRvciqlvaGSYLCGFVNSIVHTSSTF-------SLSFCGSNVINHFFCDIPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 201 TYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVahRLFSS 280
Cdd:cd15230  164 SCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYL--RPSSS 241

                        250       260
                 ....*....|....*....|....*...
gi 125719163 281 TPRVICSILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15230  242 YSLDQDKVVSVFYTVVIPMLNPLIYSLR 269
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 47-315 4.56e-42

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 147.47  E-value: 4.56e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15420   10 LYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMMSfvIGLIICIRQVFFMFPSVMAVKSV--SFQGGQELSHPFCFHPDIIKYTYTN 204
Cdd:cd15420   90 LLAVMSYDRYVAICHPLRYTVIMNWRVC--TTLAATSWACGFLLALVHVVLLLrlPFCGPNEVNHFFCEILAVLKLACAD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 205 PWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFY-VPMITLSVAHrlfSSTPR 283
Cdd:cd15420  168 TWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYgTAMFMYMVPG---SSNSA 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 125719163 284 VICSILGNMYLLLPPVLNPIIYSLKTKVIRQA 315
Cdd:cd15420  245 EQEKILSLFYSLFNPMLNPLIYSLRNKQVKGA 276
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 48-308 2.58e-41

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 145.32  E-value: 2.58e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  48 YTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFvhgFSFL---E 124
Cdd:cd15911   11 YIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYF---FGSLaatE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 125 SSVLVAMAFDRYLAICSPLKYATFLTDMM-------SFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDI 197
Cdd:cd15911   88 CYLLAVMSYDRYLAICKPLHYASLMNGRLclqlaagSWISGFLASTITVILMS-------QLTFCGPNEIDHFFCDFAPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 198 IKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRl 277
Cdd:cd15911  161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPS- 239

                        250       260       270
                 ....*....|....*....|....*....|.
gi 125719163 278 fSSTPRVICSILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15911  240 -TNTSRDLNKVFSLFYTVLTPLVNPLIYSLR 269
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 47-316 8.62e-41

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 144.37  E-value: 8.62e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15419   10 IYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMM-------SFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDIIK 199
Cdd:cd15419   90 LLAAMAYDRFIAICNPLLYPVIMSRRVcvqlvagSYLCGCINSIIQTSFTF-------SLSFCGSNEIDHFFCDVPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 200 YTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFY-VPMITLSVAHRLF 278
Cdd:cd15419  163 LSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYgTVFFMYAQPGAVS 242

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 125719163 279 SSTPRVICSIlgnMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15419  243 SPEQSKVVSV---FYTLVIPMLNPLIYSLRNKDVKEAL 277
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 38-308 1.87e-40

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 143.28  E-value: 1.87e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd15914    1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDI 197
Cdd:cd15914   81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 198 IKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVahRL 277
Cdd:cd15914  161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYL--RL 238

                        250       260       270
                 ....*....|....*....|....*....|.
gi 125719163 278 FSSTPRVICSILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15914  239 SKSYSLDYDRAIAVVYAVLTPFFNPIIYSLR 269
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 48-308 1.60e-39

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 140.49  E-value: 1.60e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  48 YTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSV 127
Cdd:cd15237   11 YLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 128 LVAMAFDRYLAICSPLKYATFLTD-------MMSFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDIIKY 200
Cdd:cd15237   91 LAVMAYDRYVAICNPLRYSVIMSRrvcvrlaATSWASGFLNSLVLTSLTL-------RLPFCGPNHINHFFCEAPAVLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 201 TYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMItlSVAHRLFSS 280
Cdd:cd15237  164 ACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAI--FMYMRPHST 241

                        250       260
                 ....*....|....*....|....*...
gi 125719163 281 TPRVICSILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15237  242 HSPDQDKMISVFYTIVTPMLNPLIYSLR 269
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 47-310 1.65e-39

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 140.76  E-value: 1.65e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15421   10 IFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAECL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNPW 206
Cdd:cd15421   90 LLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCADTS 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 207 ISSfwgmfLQLYLNGTDLL-----FILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVP-MITLSVAHRLFSS 280
Cdd:cd15421  170 AYE-----TVVYVSGVLFLlipfsLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPaIFTYMRPGSYHSP 244

                        250       260       270
                 ....*....|....*....|....*....|
gi 125719163 281 TPRVICSILgnmYLLLPPVLNPIIYSLKTK 310
Cdd:cd15421  245 EQDKVVSVF---YTILTPMLNPLIYSLRNK 271
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 47-316 2.16e-39

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 140.53  E-value: 2.16e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15411   10 IYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTD-------MMSFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDIIK 199
Cdd:cd15411   90 LLGLMAYDRYVAICNPLLYTVVMSRrvclklaAGSYAAGFLNSLIHTTLIS-------RLSFCGSNVINHFFCDTPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 200 YTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMI-TLSVAHRLF 278
Cdd:cd15411  163 LSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIfTYLRPSSSY 242

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 125719163 279 SSTPRVICSILgnmYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15411  243 SLGQDKVASVF---YTVVIPMLNPLIYSLRNKEVKNAL 277
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 48-316 4.44e-39

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 139.65  E-value: 4.44e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  48 YTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSV 127
Cdd:cd15229   11 YLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 128 LVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNPWI 207
Cdd:cd15229   91 LSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFA 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 208 SSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVP-MITLSVAHRLFSSTPRVIC 286
Cdd:cd15229  171 NKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTgFFRYLRPNSASSSVLDRVF 250

                        250       260       270
                 ....*....|....*....|....*....|
gi 125719163 287 SILgnmYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15229  251 SIQ---YSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 46-315 4.47e-39

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 139.70  E-value: 4.47e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15417    9 GIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTEC 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFLTDMM-------SFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDII 198
Cdd:cd15417   89 FLLAAMAYDRYVAICNPLLYSVIMSPRLcvqlvagAYLGGFLNSLIQTVSMF-------QLSFCGPNVIDHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 199 KYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPmiTLSVAHRLF 278
Cdd:cd15417  162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGT--GLFVYLRPS 239

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 125719163 279 SSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVIRQA 315
Cdd:cd15417  240 SSHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDA 276
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 48-316 5.29e-39

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 139.49  E-value: 5.29e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  48 YTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSV 127
Cdd:cd15424   11 YLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 128 LVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNPWI 207
Cdd:cd15424   91 LGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTHI 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 208 SSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLFSSTPRVicS 287
Cdd:cd15424  171 TEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGSTPDRD--K 248

                        250       260
                 ....*....|....*....|....*....
gi 125719163 288 ILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15424  249 QIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 47-308 2.21e-38

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 137.77  E-value: 2.21e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15232   10 LYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATfltdMMS--FVIGLIICIRQVFFMFPSVMA--VKSVSFQGGQELSHPFCFHPDIIKYTY 202
Cdd:cd15232   90 LLTAMAYDRYVAICHPLHYST----IMRkeVCVGLATGVWAIGMLNSAVHTglMLRLSFCGPNIINHFFCEIPPLLLLSC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 203 TNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVahRLFSSTP 282
Cdd:cd15232  166 SDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYI--RPSSSYS 243

                        250       260
                 ....*....|....*....|....*.
gi 125719163 283 RVICSILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15232  244 PEKDKVVAVLYSVVTPTLNPLIYSLR 269
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 48-308 4.35e-38

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 137.03  E-value: 4.35e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  48 YTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSV 127
Cdd:cd15224   11 YVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 128 LVAMAFDRYLAICSPLKYATFLTDMM-------SFVIGLIICIRQVFFmfpsvmaVKSVSFQGGQELSHPFCFHPDIIKY 200
Cdd:cd15224   91 LAVMAYDRYVAICHPLRYPVIMTHQLcvqlaagSWLSGFLISMIKVYF-------ISQLSFCGPNVINHFFCDISPLLNL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 201 TYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVahrlfss 280
Cdd:cd15224  164 SCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYA------- 236

                        250       260       270
                 ....*....|....*....|....*....|...
gi 125719163 281 TPRVICS-----ILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15224  237 RPKAISSfdsnkLVSVLYTVVTPLLNPIIYCLR 269
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 47-316 5.80e-38

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 136.76  E-value: 5.80e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15412   10 IYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYY 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTD-------MMSFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDIIK 199
Cdd:cd15412   90 MLAVMAYDRYMAICNPLLYSVKMSRrvcislvTFPYIYGFLNGLIQTILTF-------RLSFCGSNVINHFYCADPPLIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 200 YTYTNPWISSFwGMFLQLYLN-GTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLF 278
Cdd:cd15412  163 LSCSDTYVKET-AMFIVAGFNlSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSE 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 125719163 279 SSTPRviCSILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15412  242 ESVEQ--SKIVAVFYTFVSPMLNPLIYSLRNKDVKQAL 277
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 46-313 7.13e-38

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 136.68  E-value: 7.13e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15408   22 LIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFATTEC 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFLTDMM-------SFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDII 198
Cdd:cd15408  102 YLLAAMAYDRYVAICNPLLYTVIMSQRVcvslvagSYLAGFLNSTVHTGFIL-------RLSFCGSNVINHFFCDGPPLL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 199 KYTYTNPWISSFWgMFLQLYLN-GTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRL 277
Cdd:cd15408  175 ALSCSDTSLNEML-LFAFVGFNvLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLFYGSLAFMYLRPSS 253

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 125719163 278 -FSSTPRVICSILgnmYLLLPPVLNPIIYSLKTKVIR 313
Cdd:cd15408  254 rYSLDLDKVASVF---YTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 46-320 7.45e-38

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 137.11  E-value: 7.45e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15943   23 VIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATTEC 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFLTDMM-------SFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDII 198
Cdd:cd15943  103 FLLAVMAYDRYVAICNPLLYTVIMSPRVciqlvagSYLIGFVNALIQTICTF-------RLPFCGSNVINHFFCDVPPLL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 199 KYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFY--VPMITLSVAHR 276
Cdd:cd15943  176 KLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIFYgtTLFMYLRPSSS 255

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 125719163 277 LFSSTPRVIcSILgnmYLLLPPVLNPIIYSLKTKVIRQAIFQLF 320
Cdd:cd15943  256 YSLDQDKVV-SVF---YTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 47-308 1.60e-37

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 135.30  E-value: 1.60e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15912   10 TYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNPW 206
Cdd:cd15912   90 LLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCSDTR 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 207 ISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITL----SVAHRL-FSST 281
Cdd:cd15912  170 LIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMyvrpSQSSSLdLNKV 249

                        250       260
                 ....*....|....*....|....*..
gi 125719163 282 PRVICSILGnmylllpPVLNPIIYSLK 308
Cdd:cd15912  250 VALLNTVVT-------PLLNPFIYTLR 269
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 47-315 2.65e-37

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 135.24  E-value: 2.65e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15407   10 IYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMM-------SFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDIIK 199
Cdd:cd15407   90 LLASMAYDRHAAVCKPLHYTTTMTTKVcacltigCYVCGFLNASIHTGNTF-------RLSFCKSNVINHFFCDIPPVLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 200 YTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITL----SVAH 275
Cdd:cd15407  163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMylqpSSSH 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 125719163 276 rlfSSTPRVICSILgnmYLLLPPVLNPIIYSLKTKVIRQA 315
Cdd:cd15407  243 ---SMDTDKMASVF---YTMVIPMLNPLVYSLRNKEVKSA 276
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 47-308 7.00e-37

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 133.48  E-value: 7.00e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15226   10 FYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMM-------SFVIGLIICIRQVFFmfpsvmaVKSVSFQGGQELSHPFCFHPDIIK 199
Cdd:cd15226   90 LLIAMAFDRYVAICKPLHYLTIMSPRMcillvvaSWIIGFIHSLSQLAF-------VVNLPFCGPNVVDSFFCDLPLVIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 200 YTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNiVAPQKQQKALSTCVCHICAVTIFYVPMITLSVahRLFS 279
Cdd:cd15226  163 LACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCIFIYV--WPFS 239

                        250       260
                 ....*....|....*....|....*....
gi 125719163 280 STPrvICSILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15226  240 TFP--VDKFLAVFYTVITPLLNPIIYTLR 266
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 47-320 7.22e-37

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 134.32  E-value: 7.22e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15410   23 IYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKAISYSGCMLQFFFFCTFVVTESF 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMM-------SFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDIIK 199
Cdd:cd15410  103 LLAVMAYDRYVAICNPLLYTVIMSRKLcvllvagSYLWGIVCSLIHTCGLL-------RLSFCGSNVINHFFCDLPPLLS 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 200 YTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVpmITLSVAHRLFS 279
Cdd:cd15410  176 LSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIFHG--TILFMYCRPSS 253

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 125719163 280 STPRVICSILGNMYLLLPPVLNPIIYSLKTKVIRQAIFQLF 320
Cdd:cd15410  254 SYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 46-316 9.79e-37

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 133.65  E-value: 9.79e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15416    9 VIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVEC 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFLTD-------MMSFVIGliiCIRQVFFmfpsVMAVKSVSFQGGQELSHPFCFHPDII 198
Cdd:cd15416   89 FLLAAMAYDRYVAICNPLLYSTIMSQkvcvllvAASYLGG---CLNALVF----TTCVFSLSFCGPNEINHFFCDFPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 199 KYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLF 278
Cdd:cd15416  162 KLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 125719163 279 SSTPRVicSILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15416  242 YSMDQN--KVVSVFYMVVIPMLNPLIYSLRNKEVKGAL 277
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 46-316 1.66e-36

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 132.92  E-value: 1.66e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15409    9 AIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTEC 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFLTDMM-------SFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDII 198
Cdd:cd15409   89 FLLAAMAYDRYVAICNPLLYPVVMSNRLcvqlitaSYIGGFLHSMIHVGLTF-------RLSFCGSNEINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 199 KYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLF 278
Cdd:cd15409  162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 125719163 279 SSTPRVICSILgnMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15409  242 YALDQDMMDSL--FYTIVIPLLNPFIYSLRNKEVIDAL 277
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 47-308 1.72e-36

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 132.75  E-value: 1.72e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15947   10 FYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATF-------LTDMMSFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDIIK 199
Cdd:cd15947   90 LLAVMAFDRYVAVCRPLHYTVImhprlcvQLAALSWLSGLANSLLQTTLTL-------QLPLCGHHTLDHFFCEVPALIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 200 Y----TYTNPWISSFWGMFLQLylngTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMIT--LSV 273
Cdd:cd15947  163 LacvdTTFNELELFVASVFFLL----VPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYmyLQP 238

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125719163 274 AHRLFSSTPRVICSilgnMYLLLPPVLNPIIYSLK 308
Cdd:cd15947  239 PSSYSQDQGKFISL----FYTVVTPTLNPLIYTLR 269
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 47-308 3.02e-36

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 131.96  E-value: 3.02e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15431   10 VYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTD-------MMSFVIGLIICIRQVFFMFPsvmavksvSFQGGQELSHPFCFHPDIIK 199
Cdd:cd15431   90 LLAVMAYDRFVAICNPLRYTLIMSWrvciqlaAGSWVSAFLLTVIPVLTMPL--------HFCGPNVINHFFCEVQALLK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 200 YTYTNP-------WISSFWGMFLQlylngtdLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFY-VPMITL 271
Cdd:cd15431  162 LACSDTslneilmFATSIFTLLLP-------FSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYgTAIFMY 234

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 125719163 272 SVAHRLFSSTPRVICSILgnmYLLLPPVLNPIIYSLK 308
Cdd:cd15431  235 LRPQSKSSSDQDKIISVF---YGVVTPMLNPLIYSLR 268
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 48-316 5.16e-36

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 131.45  E-value: 5.16e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  48 YTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSV 127
Cdd:cd15233   11 YIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 128 LVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNPWI 207
Cdd:cd15233   91 LTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 208 SSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVahRLFSSTPRVICS 287
Cdd:cd15233  171 NELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYM--RLGSVYSSDKDK 248

                        250       260
                 ....*....|....*....|....*....
gi 125719163 288 ILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15233  249 VIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 40-316 3.58e-35

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 129.42  E-value: 3.58e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  40 ISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHG 119
Cdd:cd15434    3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 120 FSFLESSVLVAMAFDRYLAICSPLKYATFLTD-------MMSFVIGLIICirqvFFMFPSVMavkSVSFQGGQELSHPFC 192
Cdd:cd15434   83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPrlcwklvAMSWLIGFGNS----LVLSPLTL---SLPRCGHHRVDHFFC 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 193 FHPDIIKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLS 272
Cdd:cd15434  156 EMPALIKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMY 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 125719163 273 VAHRLFSStpRVICSILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15434  236 LQPKNSVS--QDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 48-316 6.78e-35

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 128.70  E-value: 6.78e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  48 YTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSV 127
Cdd:cd15228   11 YLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 128 LVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFfmfpSVMAVKSVSFQ----GGQELSHPFCFHPDIIKYTYT 203
Cdd:cd15228   91 YTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSF----HATILTSLTFTlpycGSNVVDYFFCDIFPVLKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 204 NPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVaHRLFSSTPR 283
Cdd:cd15228  167 DTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYT-QPTPSPVLV 245

                        250       260       270
                 ....*....|....*....|....*....|...
gi 125719163 284 VICSILGNmylLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15228  246 TPVQIFNN---VVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 47-316 2.01e-34

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 127.56  E-value: 2.01e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVL-GVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15916   10 IYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLaGFLEPGGKVISFGGCVAQLYFFHFLGSTEC 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNP 205
Cdd:cd15916   90 FLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADT 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 206 WISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVahRLFSSTPrvI 285
Cdd:cd15916  170 TINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYL--RPGSKEA--L 245

                        250       260       270
                 ....*....|....*....|....*....|.
gi 125719163 286 CSILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15916  246 DGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 47-308 2.26e-34

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 127.04  E-value: 2.26e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15915   10 LYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAM 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYaTFLTDMMSFVIGLIICIRQVFF--MFPSVMAVKsVSFQGGQELSHPFCFHPDIIKY---- 200
Cdd:cd15915   90 LLAVMAYDRYVAICNPLRY-TVIMNPQVCLLLAVACWVTGFFhaLMHTVMTSR-LPFCGPNKINHFFCDIKPLLKLacgd 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 201 TYTNPWISSFWGMFLQLYLngtdLLFILFSYVLILRTVLNIVAPQK-QQKALSTCVCHICAVTIFYVPMITLSVAHRLFS 279
Cdd:cd15915  168 TSLNLWLLNIVTGSIALGT----FILTLLSYIYIISFLLLKVRSKEgRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGD 243

                        250       260
                 ....*....|....*....|....*....
gi 125719163 280 STPRVICSILgnMYLLLPPVLNPIIYSLK 308
Cdd:cd15915  244 SLEQDRIVAL--LYTVVTPVLNPLIYTLR 270
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 47-316 4.00e-34

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 126.39  E-value: 4.00e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15942   10 VYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNPW 206
Cdd:cd15942   90 LYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 207 ISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMitlsVAHRLFSSTPRVIC 286
Cdd:cd15942  170 FNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPL----TFIYLRPGSQDPLD 245

                        250       260       270
                 ....*....|....*....|....*....|
gi 125719163 287 SILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15942  246 GVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 47-308 5.63e-34

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 126.05  E-value: 5.63e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15946   10 IYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNPW 206
Cdd:cd15946   90 LFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADTS 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 207 ISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLFSSTPRVic 286
Cdd:cd15946  170 LNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNYSPERD-- 247

                        250       260
                 ....*....|....*....|..
gi 125719163 287 SILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15946  248 KKISLFYNVFTALLNPVIYSLR 269
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 46-316 1.46e-33

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 125.22  E-value: 1.46e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15415    9 LIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNP 205
Cdd:cd15415   89 FLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDT 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 206 WISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPmITLSVAH--RLFSSTPR 283
Cdd:cd15415  169 HINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGS-VSFSYIQpsSQYSLEQE 247

                        250       260       270
                 ....*....|....*....|....*....|...
gi 125719163 284 VICSILgnmYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15415  248 KVSAVF---YTLVIPMLNPLIYSLRNKDVKDAL 277
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 47-318 2.44e-33

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 124.86  E-value: 2.44e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15945   23 VYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCALQMFFFAAFADAECL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYAtflTDMMSFVIGLIICIRQVFFMFPSVMAVK---SVSFQGGQELSHPFCFHPDIIKYTYT 203
Cdd:cd15945  103 LLAVMAYDRYVAICNPLLYT---TAMSRRVCYLLLVGAYLSGMATSLVHTTltfRLSFCGSNTINHFFCDIPPLLALSCS 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 204 NPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVahRLFSSTPR 283
Cdd:cd15945  180 DTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLFYGTLLFMYL--RPSSSYSL 257

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125719163 284 VICSILGNMYLLLPPVLNPIIYSLKTKVIRQAIFQ 318
Cdd:cd15945  258 DTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 47-320 5.30e-33

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 124.13  E-value: 5.30e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15944   23 IYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFVDAECY 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNPW 206
Cdd:cd15944  103 VLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSNIINHFFCDVPPLLALSCSDTH 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 207 ISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSV-AHRLFSSTPRVI 285
Cdd:cd15944  183 INEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLFYGTVIFMYLrPTSVYSLDQDKW 262

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125719163 286 CSILgnmYLLLPPVLNPIIYSLKTKVIRQAIFQLF 320
Cdd:cd15944  263 ASVF---YTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 46-316 7.45e-33

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 123.34  E-value: 7.45e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15236    9 AMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNP 205
Cdd:cd15236   89 FLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSST 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 206 WISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMItlSVAHRLFSSTPRVI 285
Cdd:cd15236  169 SLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTII--GVYFFPSSNNSSDK 246

                        250       260       270
                 ....*....|....*....|....*....|.
gi 125719163 286 CSILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15236  247 DIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 46-308 7.81e-33

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 122.86  E-value: 7.81e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15430    9 IMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTEC 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFL-----TDMM--SFVIGLIICIRQVFFMFPsvmavksVSFQGGQELSHPFCFHPDII 198
Cdd:cd15430   89 VLLAVMAYDRYVAICNPLRYPIIMnkrlcVQMAagSWVTGFLNSLVETVLAMQ-------LPFCGNNVINHFTCEILAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 199 KYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRlf 278
Cdd:cd15430  162 KLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPK-- 239

                        250       260       270
                 ....*....|....*....|....*....|
gi 125719163 279 SSTPRVICSILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15430  240 SKNAQISDKLITLFYGVVTPMLNPIIYSLR 269
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 46-316 1.04e-32

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 122.97  E-value: 1.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15428    9 IIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITEC 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNP 205
Cdd:cd15428   89 ALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDT 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 206 WISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRlfSSTPRVI 285
Cdd:cd15428  169 HQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPK--SSTSKEY 246

                        250       260       270
                 ....*....|....*....|....*....|.
gi 125719163 286 CSILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15428  247 DKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 47-308 1.42e-32

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 122.16  E-value: 1.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15940   10 LYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTdmMSFVIGLIICIRQVFFMFPSVMAVKSVS--FQGGQELSHPFCFHPDIIKYTYTN 204
Cdd:cd15940   90 LLTIMAYDRYVAICNPLHYPTVMN--HKVCLWLVAALWLGGTVHSLAQTFLTIRlpYCGPNEIDSFFCDVPPVIKLACTD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 205 PWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVApQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLFSSTPRV 284
Cdd:cd15940  168 TYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRST-EGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSEDKV 246

                        250       260
                 ....*....|....*....|....
gi 125719163 285 ICSilgnMYLLLPPVLNPIIYSLK 308
Cdd:cd15940  247 VSV----FYTVVTPLLNPIIYTLR 266
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 48-316 1.76e-32

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 122.20  E-value: 1.76e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  48 YTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSV 127
Cdd:cd15432   11 YILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 128 LVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNPWI 207
Cdd:cd15432   91 LAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTTA 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 208 SSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVahRLFSSTPRVICS 287
Cdd:cd15432  171 NEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYL--QPPSNSSHDRGK 248

                        250       260
                 ....*....|....*....|....*....
gi 125719163 288 ILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15432  249 MVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 46-316 2.54e-32

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 122.09  E-value: 2.54e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15406   18 GIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAEC 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNP 205
Cdd:cd15406   98 YMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSCSST 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 206 WISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLFSSTPRVI 285
Cdd:cd15406  178 YINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSSSMTQEK 257

                        250       260       270
                 ....*....|....*....|....*....|.
gi 125719163 286 CSILgnMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15406  258 VSSV--FYTTVIPMLNPLIYSLRNKDVKNAL 286
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 47-308 9.99e-32

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 120.01  E-value: 9.99e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15939   10 IYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLT----DMM---SFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFC-FHPdII 198
Cdd:cd15939   90 LLTVMAYDRYVAICKPLHYTTIMNrrvcGLLvgvAWVGGFLHSTIQILLTL-------QLPFCGPNVIDHFFCdLFP-LL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 199 KYTYTNPWISSFW-----GMFLQLylngtDLLFILFSYVLILRTVLNIVApQKQQKALSTCVCHICAVTIFYVPMITLSV 273
Cdd:cd15939  162 KLACTDTYVIGLLvvansGLICLL-----SFLILLISYIVILYSLRTHSS-EGRRKALSTCGSHITVVVLFFVPCIFIYM 235

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125719163 274 ahRLFSSTPrvICSILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15939  236 --RPVTTFP--IDKVVAVFYTIITPMLNPLIYTLR 266
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 46-316 1.14e-30

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 117.58  E-value: 1.14e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15418   10 LSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSEC 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFLTDmmSFVIGLIICIRQVFFMFPSVMAVK--SVSFQGGQELSHPFCFHPDIIKYTYT 203
Cdd:cd15418   90 FLLAAMAYDRYVAICNPLLYSSAMSK--KLCMGLVAASYLGGFANAIIHTSNtfRLHFCGDNIIDHFFCDLPPLVKLACD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 204 NPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLFSSTPR 283
Cdd:cd15418  168 DTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHTPDR 247

                        250       260       270
                 ....*....|....*....|....*....|...
gi 125719163 284 VicSILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15418  248 D--KVVALFYTVVNPLLNPLIYSLRNKDVKEAL 278
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 48-323 1.45e-30

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 117.14  E-value: 1.45e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  48 YTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSV 127
Cdd:cd15414   11 YLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 128 LVAMAFDRYLAICSPLKYATFLTDMM-------SFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDIIKY 200
Cdd:cd15414   91 LASMAYDRYVAICNPLLYTVIMSQRVcvqlvvgPYVVGLLNTTTHTTAAF-------FLPFCGPNVINHFFCDIPPLLSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 201 TYTNPWISSfWGMFLQLYLNGT-DLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVahRLFS 279
Cdd:cd15414  164 SCADTQINK-WVLFIMAGALGVlSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYV--RPSS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 125719163 280 STPRVICSILGNMYLLLPPVLNPIIYSLKTKVIRQAIFQLFRFK 323
Cdd:cd15414  241 SSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRK 284
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 46-315 2.10e-30

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 116.73  E-value: 2.10e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15429    9 VMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFLTDMM-------SFVIGLIICIRQVFFMFpsvmavkSVSFQGGQELSHPFCFHPDII 198
Cdd:cd15429   89 ILLAVMAYDRYVAVCHPLRYTVIMSGGLciqlaaaSWTSGFLNSLVQTAFTF-------RLPFCGHNTINHFSCELLAVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 199 KYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAHRLF 278
Cdd:cd15429  162 RLACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSG 241

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 125719163 279 SSTPRVicSILGNMYLLLPPVLNPIIYSLKTKVIRQA 315
Cdd:cd15429  242 SSALQE--KMISLFYAVVTPMLNPLIYSLRNKEVKGA 276
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 47-308 2.39e-30

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 116.28  E-value: 2.39e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15936   10 VYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMM-------SFVIGLIICIRQVFFMFPsvmavksVSFQGGQELSHPFCFHPDIIK 199
Cdd:cd15936   90 LLSVMAYDRYIAIHKPLHYLTIMNQGVctglvagSWLGGFAHSIVQVALLLQ-------LPFCGPNVLDNFYCDVPQVIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 200 YTYTNPWISSfwgmFLQLYLNGTDLLFILF----SYVLILRTVLNIVAPQKqQKALSTCVCHICAVTIFYVPMItLSVAH 275
Cdd:cd15936  163 LACTDTFLLE----LLMVSNSGLVTLLIFFilliSYTVILVKIRTHVTEGK-RKALSTCASQITVVTLIFVPCI-YIYAR 236

                        250       260       270
                 ....*....|....*....|....*....|...
gi 125719163 276 RLFSSTPRVICSILgnmYLLLPPVLNPIIYSLK 308
Cdd:cd15936  237 PFQTFPMDKAVSVL---YTVITPMLNPMIYTLR 266
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 47-316 1.52e-29

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 114.34  E-value: 1.52e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15413   10 IYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNPW 206
Cdd:cd15413   90 LLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTH 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 207 ISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSV----AHRLFSSTp 282
Cdd:cd15413  170 EKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLqpksSHSLDTDK- 248

                        250       260       270
                 ....*....|....*....|....*....|....
gi 125719163 283 rvICSILgnmYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15413  249 --MASVF---YTLVIPMLNPLIYSLRNKEVKDAL 277
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 48-316 1.03e-28

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 112.19  E-value: 1.03e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  48 YTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSV 127
Cdd:cd15433   11 YLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 128 LVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNPWI 207
Cdd:cd15433   91 LAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDET 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 208 SSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMIT--LSVAHRLFSSTPRVI 285
Cdd:cd15433  171 TEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYtyLQPIHRYSQAHGKFV 250

                        250       260       270
                 ....*....|....*....|....*....|.
gi 125719163 286 CSilgnMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15433  251 SL----FYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 48-308 3.95e-28

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 110.24  E-value: 3.95e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  48 YTIALLGNSIILFVIIIERSLHK-PMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15935   11 YAAILLGNLLIVVTVHADPHLLQsPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEML 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMMSFVI-------GLIICIRQVFFmfpsvmaVKSVSFQGGQELSHPFCFHPDIIK 199
Cdd:cd15935   91 LLTLMAYDRYVAICHPLRYLAVMNRQLCIKLlaacwagGFLHSATQAAL-------VLRLPFCGPNELDNFYCDVPQVIK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 200 YTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVApQKQQKALSTCVCHICAVTIFYVPMITlsVAHRLFS 279
Cdd:cd15935  164 LACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFR-EGGGKALSTCSSHLTVVSLIFVPCIF--VYLRPFS 240

                        250       260
                 ....*....|....*....|....*....
gi 125719163 280 STPrvICSILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15935  241 SSS--VDKVASVFYTLITPALNPLIYTLR 267
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 47-316 6.05e-28

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 109.94  E-value: 6.05e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHK-PMYYFLSMLSVVDLGLTITTLPTVL-GVLWFHAREISIKVCLIQMFFVHGFSFLE 124
Cdd:cd15941   10 IYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLaGLLTLSGRTISFEGCVVQLYAFHFLASTE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 125 SSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTN 204
Cdd:cd15941   90 CFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACAD 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 205 PWISSFWgMFLQLYLNGTD-LLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPmitlSVAHRLFSSTPR 283
Cdd:cd15941  170 TTINELV-ILANIGIVAAGcFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVP----SVFIYLQPSSSQ 244

                        250       260       270
                 ....*....|....*....|....*....|...
gi 125719163 284 VICSILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15941  245 AGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 47-308 8.24e-28

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 109.71  E-value: 8.24e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15913   10 IYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTdmMSFVIGLII-CIRQVFFMFP-SVMAVKSVSFQGGQELSHPFCFHPDIIKYTYT- 203
Cdd:cd15913   90 FLSVMAFDRYLAICRPLHYPTIMT--GQLCGKLVAfCWVCGFLWFLiPVVLISQLPFCGPNIIDHFLCDPGPLLALSCVp 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 204 NPWISSFWGMFLQLYLNGTdLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVAhrLFSSTPR 283
Cdd:cd15913  168 APGTELICYTLSSLIIFGT-FLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVS--PGSGNST 244

                        250       260
                 ....*....|....*....|....*
gi 125719163 284 VICSILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15913  245 GMQKIVTLFYSVVTPLLNPLIYSLR 269
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 48-308 3.92e-27

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 107.65  E-value: 3.92e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  48 YTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSV 127
Cdd:cd15938   11 YTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 128 LVAMAFDRYLAICSPLKYATFLTDMMSFVigLIICIRQVFFMFPSVMAVKSVS--FQGGQELSHPFCFHPDIIKYTYTNP 205
Cdd:cd15938   91 LTVMAYDRYVAICKPLHYTTIMSRRLCWV--LVAASWAGGFLHSIVQTLLTIQlpFCGPNQVNNFFCDVPPVIKLACTDT 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 206 WISSFWGMFLQLYLNGTDLLFILFSYVLILrtvLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVahRLFSSTP--R 283
Cdd:cd15938  169 CVTELLMVSNSGLISTVCFVVLVTSYTTIL---VTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYA--RPFSTFPvdK 243

                        250       260
                 ....*....|....*....|....*
gi 125719163 284 VICSIlgnmYLLLPPVLNPIIYSLK 308
Cdd:cd15938  244 HVSVL----YNVITPMLNPLIYTLR 264
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 46-316 1.07e-26

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 106.73  E-value: 1.07e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15405    9 GIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISEC 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLKYatflTDMMSFVIGLIICIRQVFFMFPSVMA----VKSVSFQGGQELSHPFCFHPDIIKYT 201
Cdd:cd15405   89 YVLTAMAYDRYVAICNPLLY----TVTMSPQVCSLLMLGSYVMGFAGAMAhtgcMLRLTFCDSNIINHYMCDILPLLQLS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 202 YTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFY--------VPMITLSV 273
Cdd:cd15405  165 CTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFgsgafmylKPSSVGSV 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 125719163 274 AHRLFSSTprvicsilgnMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15405  245 NQGKVSSV----------FYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 47-308 1.79e-23

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 97.50  E-value: 1.79e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15937   10 FYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEMF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTD-------MMSFVIGLIICIRQVFFMFPsvmavksVSFQGGQELSHPFCFHPDIIK 199
Cdd:cd15937   90 LLVAMAYDRYVAICKPLHYTTVVNRrvccvlvGASWAGGFIHSIIQVALIIR-------LPFCGPNVLDNFFCDITQVIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 200 YTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILrTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVahRLFS 279
Cdd:cd15937  163 LACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYA--RPFR 239

                        250       260
                 ....*....|....*....|....*....
gi 125719163 280 STPrvICSILGNMYLLLPPVLNPIIYSLK 308
Cdd:cd15937  240 SFP--MDKVVAVFHTVIFPLLNPMIYTLR 266
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 54-305 3.95e-20

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 88.12  E-value: 3.95e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163   54 GNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLP-TVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSVLVAMA 132
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPfWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  133 FDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGqelSHPFCFhPDIIKYTYTNPWISSFWg 212
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG---NVTVCF-IDFPEDLSKPVSYTLLI- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  213 MFLQLYLngtDLLFILFSYVLILRTVLNIVAPQKQ-------QKALSTCVCHICAVTIFYVP----MITLSVAHRLFSST 281
Cdd:pfam00001 156 SVLGFLL---PLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPyhivNLLDSLALDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 125719163  282 PRVICSILGNMYLLLPPVLNPIIY 305
Cdd:pfam00001 233 LLDKALSVTLWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 50-308 7.97e-17

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 79.25  E-value: 7.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  50 IALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSVLV 129
Cdd:cd00637   11 VGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 130 AMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHPDIIKYTYTNpwiss 209
Cdd:cd00637   91 AISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKAYTIFL----- 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 210 fwgMFLQLYLNgtdLLFILFSYVLILRTVLNIVAP--------------QKQQKALSTCVCHICAVTIFYVPMITLSVAH 275
Cdd:cd00637  166 ---FVLLFLLP---LLVIIVCYVRIFRKLRRHRRRirssssnssrrrrrRRERKVTKTLLIVVVVFLLCWLPYFILLLLD 239

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 125719163 276 RLFSSTPRVIcSILGNMYLLLP---PVLNPIIYSLK 308
Cdd:cd00637  240 VFGPDPSPLP-RILYFLALLLAylnSAINPIIYAFF 274
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 39-316 3.38e-10

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 59.88  E-value: 3.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  39 WISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLP-----TVLGVLWFHAReisikVCLIQ 113
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPfsavyTLLGYWPFGPV-----LCRFW 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 114 MFFVHGFSFLESSVLVAMAFDRYLAICSPLKYATFLTdmmSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCF 193
Cdd:cd14967   76 IALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMT---KKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECE 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 194 HPDIIKYTytnpWISSFWGMFLQlylngtdLLFILFSYVLILRTVlnivapQKQQKALSTCVCHICAVTIFYVPMITLSV 273
Cdd:cd14967  153 FTPNKIYV----LVSSVISFFIP-------LLIMIVLYARIFRVA------RRELKAAKTLAIIVGAFLLCWLPFFIIYL 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 125719163 274 --AHRLFSSTPRV---ICSILGNmyllLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd14967  216 vsAFCPPDCVPPIlyaVFFWLGY----LNSALNPIIYALFNRDFRRAF 259
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 49-171 8.88e-09

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 55.68  E-value: 8.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  49 TIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSVL 128
Cdd:cd14969   12 VLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 125719163 129 VAMAFDRYLAICSPLKYaTFLTDMMSFVIGLIICIRQVFFMFP 171
Cdd:cd14969   92 AALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYGLFWALP 133
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
 45-167 2.02e-08

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 54.55  E-value: 2.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  45 CGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLgltITTLPTVLGVL-W-----FHAreiSIKVC-LIQMFFV 117
Cdd:cd15196    8 ATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADL---LVALFNVLPQLiWdityrFYG---GDLLCrLVKYLQV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 125719163 118 HGFsFLESSVLVAMAFDRYLAICSPLKYATFLTDMM------SFVIGLIICIRQVF 167
Cdd:cd15196   82 VGM-YASSYVLVATAIDRYIAICHPLSSHRWTSRRVhlmvaiAWVLSLLLSIPQLF 136
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
 50-181 2.76e-08

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 54.77  E-value: 2.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  50 IALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVL-----GVLWFHAREISIKVCLIQMFFVHGFSFLe 124
Cdd:cd15005   13 VSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMasvrhGSGWIYGALSCKVIAFLAVLFCFHSAFT- 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 125719163 125 ssvLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSF 181
Cdd:cd15005   92 ---LFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTF 145
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
 50-253 4.03e-08

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 53.76  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  50 IALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLG----VLWFHAREISIKVCLIQMFFVhgfsflES 125
Cdd:cd14993   13 LALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLenvyRPWVFGEVLCKAVPYLQGVSV------SA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SV--LVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPS--VMAVKSVSFQGGQELSHPFCfhpdiikyt 201
Cdd:cd14993   87 SVltLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLlvVYELEEIISSEPGTITIYIC--------- 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 125719163 202 yTNPWISSFWGMFLQLYLNGT----DLLFILFSYVLILRTVLNIVAPQKQQKALST 253
Cdd:cd14993  158 -TEDWPSPELRKAYNVALFVVlyvlPLLIISVAYSLIGRRLWRRKPPGDRGSANST 212
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
 45-150 5.47e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 53.45  E-value: 5.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  45 CGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVhgFSFLE 124
Cdd:cd14972    6 IVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLV--LSLLA 83

                         90       100
                 ....*....|....*....|....*..
gi 125719163 125 SSV-LVAMAFDRYLAICSPLKYATFLT 150
Cdd:cd14972   84 SAYsLLAIAVDRYISIVHGLTYVNNVT 110
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
 44-163 1.77e-07

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 51.89  E-value: 1.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  44 VCGLytIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFL 123
Cdd:cd15074    9 VIGI--LSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCC 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 125719163 124 ESSVLVAMAFDRYLAICSPlKYATFLTdmMSFVIGLIICI 163
Cdd:cd15074   87 SINTLTAISIYRYLKICHP-PYGPKLS--RRHVCIVIVAI 123
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
 38-240 3.32e-07

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 51.17  E-value: 3.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIpvCGLytIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKV-CLIQMFF 116
Cdd:cd15337    5 IYIAI--VGI--LGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGFPLKTISSFNKKWIWGKVaCELYGFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 117 VHGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQeLSHPFcfhpD 196
Cdd:cd15337   81 GGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPEGFQ-TSCTF----D 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 125719163 197 IIKYTYTNpwISSFWGMFLQLYLngTDLLFILFSYVLILRTVLN 240
Cdd:cd15337  156 YLSRDLNN--RLFILGLFIFGFL--CPLLIIIFCYVNIIRAVRN 195
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
 42-150 4.59e-07

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 50.79  E-value: 4.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  42 IPVCGLytIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFS 121
Cdd:cd15083    7 ILIIGL--IGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFG 84

                         90       100
                 ....*....|....*....|....*....
gi 125719163 122 FLESSVLVAMAFDRYLAICSPLKYATFLT 150
Cdd:cd15083   85 IMSINTLAAIAVDRYLVITRPMKASVRIS 113
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
 46-150 1.18e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 49.28  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPT-VLGVLWFHAREISIKVCLIQMFFVHGFSFLE 124
Cdd:cd14979    9 AIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVeLYNFWWQYPWAFGDGGCKLYYFLFEACTYAT 88

                         90       100
                 ....*....|....*....|....*.
gi 125719163 125 SSVLVAMAFDRYLAICSPLKYATFLT 150
Cdd:cd14979   89 VLTIVALSVERYVAICHPLKAKTLVT 114
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
 40-163 1.54e-06

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 49.25  E-value: 1.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  40 ISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLW-FHAREISIKVCLIQMFFVH 118
Cdd:cd15134    3 ITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWqQYPWVFGEVFCKLRAFLSE 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 125719163 119 GFSFLESSVLVAMAFDRYLAICSPLKYATFLTdmMSFVIGLIICI 163
Cdd:cd15134   83 MSSYASVLTITAFSVERYLAICHPLRSHTMSK--LSRAIRIIIAI 125
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 45-147 5.23e-06

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 47.42  E-value: 5.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  45 CGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLgvLW-----FHAREIsikVCLIQMFFVHG 119
Cdd:cd15197    8 WVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDI--IWritveWRAGDF---ACKVIRYLQVV 82

                         90       100
                 ....*....|....*....|....*...
gi 125719163 120 FSFLESSVLVAMAFDRYLAICSPLKYAT 147
Cdd:cd15197   83 VTYASTYVLVALSIDRYDAICHPMNFSQ 110
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
 50-161 6.46e-06

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 47.28  E-value: 6.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  50 IALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHareisiKVCLIQMFFVHGFSFLESSV-- 127
Cdd:cd14997   13 VGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAR------EPWLLGEFMCKLVPFVELTVah 86

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 125719163 128 -----LVAMAFDRYLAICSPLKYATFLTDMMSFVIGLII 161
Cdd:cd14997   87 asvltILAISFERYYAICHPLQAKYVCTKRRALVIIALI 125
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 37-241 1.21e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 46.47  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  37 HVWISIPVCglyTIALLGNSIILFVIIiERSLHKPMYYFLSMLSVVDLGLTITTLPTVLG-VLWFHAREISIKVCLIQMF 115
Cdd:cd14978    3 YGYVLPVIC---IFGIIGNILNLVVLT-RKSMRSSTNVYLAALAVSDILVLLSALPLFLLpYIADYSSSFLSYFYAYFLP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 116 FVHGFS--FLESSV--LVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSfqggqelshpf 191
Cdd:cd14978   79 YIYPLAntFQTASVwlTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVE----------- 147

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 125719163 192 CFHPDIIKYTYTNPWISSFWGMFLQLYLNgtdLLFILFSYVL--ILRTVLNI 241
Cdd:cd14978  148 CENCNNNSYYYVIPTLLRQNETYLLKYYF---WLYAIFVVLLpfILLLILNI 196
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
 42-238 1.70e-05

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 45.89  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  42 IPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPT----VLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd15384    5 VVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSeaiwAYTVAWLAGNTMCKLVKYLQVFGL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 118 HgfsfLESSVLVAMAFDRYLAICSPLKYAT-------FLTdmMSFVIGLIICIRQVFFMfpsvmavksvsfqggQELSHP 190
Cdd:cd15384   85 Y----LSTYITVLISLDRCVAILYPMKRNQapervrrMVT--VAWILSPIFSIPQAVIF---------------HVERGP 143

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 125719163 191 FC--FHPDIIKYTYTNPWISSFWGMFLQLYLNGTDLLFILFSYVLILRTV 238
Cdd:cd15384  144 FVedFHQCVTYGFYTAEWQEQLYNMLSLVFMFPIPLVIMVTCYVLIFITL 193
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
 50-181 2.23e-05

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 45.71  E-value: 2.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  50 IALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVL-----GVLWFHareiSIKVCLIQMFFVHGFSFLE 124
Cdd:cd15217   13 VSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLvsirnGSAWTY----SVLSCKIVAFMAVLFCFHA 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 125719163 125 SSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSF 181
Cdd:cd15217   89 AFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTYKF 145
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
 52-236 2.51e-05

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 45.34  E-value: 2.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  52 LLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIqMFFVHGFSFLeSSV--LV 129
Cdd:cd15001   14 LIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKA-VAYLQLLSFI-CSVltLT 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 130 AMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCFHpdiikyTYTNPWISS 209
Cdd:cd15001   92 AISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQK------AWPSTLYSR 165

                        170       180
                 ....*....|....*....|....*..
gi 125719163 210 FWGMFLQLYLNGTDLLFILFSYVLILR 236
Cdd:cd15001  166 LYVVYLAIVIFFIPLIVMTFAYARDTR 192
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 50-167 3.60e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 44.81  E-value: 3.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  50 IALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTI-TTLPTVLGVLWFHAREISIKVCLIQMFFVHGFsFLESSVL 128
Cdd:cd15387   13 LALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDITFRFYGPDFLCRLVKYLQVVGM-FASTYML 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 125719163 129 VAMAFDRYLAICSPLKYATFLTDMM----SFVIGLIICIRQVF 167
Cdd:cd15387   92 LLMSIDRCLAICQPLRSLHRRSDRVyvlfSWLLSLVFSIPQVH 134
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
 47-159 5.10e-05

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 44.54  E-value: 5.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGV-LWFharEISIKVCLIQMFFVhgFSFLES 125
Cdd:cd15069   10 IAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITIsLGF---CTDFHSCLFLACFV--LVLTQS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 125719163 126 SV--LVAMAFDRYLAICSPLKYATFLTD-----------MMSFVIGL 159
Cdd:cd15069   85 SIfsLLAVAVDRYLAIKVPLRYKSLVTGkrargviavlwVLAFGIGL 131
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
 47-163 6.53e-05

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 44.26  E-value: 6.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15065    9 IIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASIL 88

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMMSFVIglIICI 163
Cdd:cd15065   89 NLCAISLDRYIHIKKPLKYERWMTTRRALVV--IASV 123
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
 47-150 8.00e-05

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 43.63  E-value: 8.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLgLTITTLPTVLGVLW-FHAREISIKVCLIQMFFVHGFSFLES 125
Cdd:cd15928   10 LMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDL-LIFLVLPLDLYRLWrYRPWRFGDLLCRLMYFFSETCTYASI 88

                         90       100
                 ....*....|....*....|....*
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFLT 150
Cdd:cd15928   89 LHITALSVERYLAICHPLRAKVLVT 113
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
 39-148 1.06e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 43.36  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  39 WISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLP-TVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd15305    2 WPALLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPvSLIAILYDYAWPLPRYLCPIWISLD 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATF 148
Cdd:cd15305   82 VLFSTASIMHLCAISLDRYVAIRNPIEHSRF 112
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
 45-250 1.16e-04

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 43.19  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  45 CGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLE 124
Cdd:cd14992    8 VVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYAS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 125 SSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKS-VSFQGGQELSHPFCFHPDIIKYTYT 203
Cdd:cd14992   88 SLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTeVLFSVKNQEKIFCCQIPPVDNKTYE 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 125719163 204 NpwiSSFWGMFLQLYlnGTDLLFILFSYVLILRTVLNIVAPQKQQKA 250
Cdd:cd14992  168 K---VYFLLIFVVIF--VLPLIVMTLAYARISRELWFRKVPGFSIKE 209
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
 39-148 1.17e-04

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 43.00  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  39 WISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLP-TVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd15304    2 WPALLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLD 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATF 148
Cdd:cd15304   82 VLFSTASIMHLCAISLDRYIAIRNPIHHSRF 112
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
 51-203 1.41e-04

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 42.88  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  51 ALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSVLVA 130
Cdd:cd15202   14 SLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTLTA 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 125719163 131 MAFDRYLAICSPLKyaTFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCF-----HPDIIKYTYT 203
Cdd:cd15202   94 IAVDRYQAIMHPLK--PRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLedwpeRADLFWKYYD 169
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 43-316 1.53e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 42.82  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  43 PVCGLYTI----ALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTI----TTLPTVLGVLWFHAReisikVCLIQM 114
Cdd:cd15012    1 IFIILYTLvfccCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIfcvlQNLSIYLIPSWPFGE-----VLCRMY 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 115 FFVHGFSFLESS-VLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFCF 193
Cdd:cd15012   76 QFVHSLSYTASIgILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQEEEIC 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 194 HPDIIKYTytnpwiSSFWGMFLQLYLNGTDLLFILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVP-----M 268
Cdd:cd15012  156 VLDREMFN------SKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRKVVRLLVAVVVSFALCNLPyharkM 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 125719163 269 ITLSVAHRLFSSTPRVICSILGNMYLLLPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd15012  230 WQYWSEPYRCDSNWNALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
 42-144 2.12e-04

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 42.36  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  42 IPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLT-ITTLPTVLGVL---WFHAREISIKVCLIQMFFV 117
Cdd:cd14986    5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAfFTVLTQIIWEAtgeWVAGDVLCRIVKYLQVVGL 84

                         90       100
                 ....*....|....*....|....*..
gi 125719163 118 HGFSFLessvLVAMAFDRYLAICSPLK 144
Cdd:cd14986   85 FASTYI----LVSMSLDRYQAIVKPMS 107
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
 47-167 2.38e-04

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 42.45  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTI-TTLPTVLGVLWFHAREISIKVCLIQMFFVHGFsFLES 125
Cdd:cd15388   10 IFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFfQVLPQLVWDITDRFRGPDVLCRLVKYLQVVGM-FASS 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 125719163 126 SVLVAMAFDRYLAICSPLkyATF--------LTDMMSFVIGLIICIRQVF 167
Cdd:cd15388   89 YMIVAMTFDRHQAICRPM--VTFqkgrarwnGPVCVAWAISLILSLPQVF 136
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
 38-150 5.08e-04

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 41.16  E-value: 5.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLP----TVLGVLWFHARE-----ISIK 108
Cdd:cd15064    1 VLISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPlsavYELTGRWILGQVlcdiwISLD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 125719163 109 VCLIQMFFVHgfsflessvLVAMAFDRYLAICSPLKYATFLT 150
Cdd:cd15064   81 VTCCTASILH---------LCVIALDRYWAITDAVEYAHKRT 113
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
 52-192 6.03e-04

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 41.07  E-value: 6.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  52 LLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFfVHGFSfLESSV--LV 129
Cdd:cd15207   15 VVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPL-VQGVS-VAASVftLV 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 125719163 130 AMAFDRYLAICSPLKYAtfLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFC 192
Cdd:cd15207   93 AIAVDRYRAVVHPTEPK--LTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRGQTVHIC 153
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
 52-266 6.33e-04

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 40.90  E-value: 6.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  52 LLGNSIILFVIIIERSLHKPMYYFLSMLSVVD----LGLTITTLPTVLGVLWFHAREIsikvCLIQMFFVHGFSFLESSV 127
Cdd:cd15088   15 LVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADllfmLGMPFLIHQFAIDGQWYFGEVM----CKIITALDANNQFTSTYI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 128 LVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHpFCFHPDIIKYTYTnpwI 207
Cdd:cd15088   91 LTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTFCY-VSLPSPDDLYWFT---I 166

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 125719163 208 SSFWGMFLqlylngTDLLFILFSYVLILRTVLNIVAPQKQ----QKALSTCVCHICAVTIFYV 266
Cdd:cd15088  167 YHFILGFA------VPLVVITVCYILILHRLARGVAPGNQshgsSRTKRVTKMVILIVVVFIV 223
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
 39-307 6.39e-04

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 41.30  E-value: 6.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  39 WISIPVCGLYTIALLGNsIILFVIIIERSLHKPMYYFLSMLSVVDLgLTITTLPTVLGVLWFHAREISIKVCLIQMFFVH 118
Cdd:PHA03087  42 ILIVVYSTIFFFGLVGN-IIVIYVLTKTKIKTPMDIYLLNLAVSDL-LFVMTLPFQIYYYILFQWSFGEFACKIVSGLYY 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 119 GFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPsVMAVKSVSFQGGQELSHPFcfhpdii 198
Cdd:PHA03087 120 IGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTP-ILFVYTTKKDHETLICCMF------- 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 199 kytYTNPwiSSFWGMFLQLYLNGTDLLF----ILFSYVLILRTVLNIVAPQKQQKALSTCVCHICAVTIFYVPMITLSVA 274
Cdd:PHA03087 192 ---YNNK--TMNWKLFINFEINIIGMLIpltiLLYCYSKILITLKGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFV 266

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 125719163 275 HRLFSSTPRVICSILGNMYLLLPPV---------LNPIIYSL 307
Cdd:PHA03087 267 YSLHILHFKSGCKAVKYIQYALHVTeiislshccINPLIYAF 308
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
 49-253 7.34e-04

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 40.67  E-value: 7.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  49 TIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLP-TVLGVLWFHAREISIkVCLIqMFFVHGFSFLESSV 127
Cdd:cd15203   12 VLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPfTLIYTLTKNWPFGSI-LCKL-VPSLQGVSIFVSTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 128 -LVAMAFDRYLAICSPLKyaTFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQE-LSHPFCFH---PDIIKYTY 202
Cdd:cd15203   90 tLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEILpYCGYFCTEswpSSSSRLIY 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 125719163 203 TnpwISSFwgmFLQLYLngtDLLFILFSYVLILRTVLNIVAPQKQQKALST 253
Cdd:cd15203  168 T---ISVL---VLQFVI---PLLIISFCYFRISLKLRKRVKKKRGKRTLSS 209
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
 38-148 8.76e-04

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 40.51  E-value: 8.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPvcgLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLgLTITTLPTVLGvLWFHaREISIKVCLIqMFFV 117
Cdd:cd15905    2 FWLSVP---LSSLIIFANLFIILGIACNRKLHNTANYFFLSLLLADL-LTGVALPFIPG-MSNE-SRRGYHSCLF-VYVA 74

                         90       100       110
                 ....*....|....*....|....*....|..
gi 125719163 118 HGFSFLES-SVLVAMAFDRYLAICSPLKYATF 148
Cdd:cd15905   75 PNFLFLSFlANLLMVHYERYLCIVYPLQYHNF 106
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
 40-236 9.29e-04

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 40.36  E-value: 9.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  40 ISIPV--CGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLgLTITTLPTVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd14970    1 IVIPAvySVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADE-LFLLGLPFLATSYLLGYWPFGEVMCKIVLSVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGqelshpfcfhpdI 197
Cdd:cd14970   80 AYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGG------------T 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 125719163 198 IKYTYTNPWISSFWGMFLQLYLN----GTDLLFILFSYVLILR 236
Cdd:cd14970  148 ISCNLQWPDPPDYWGRVFTIYTFvlgfAVPLLVITVCYSLIIR 190
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
 47-145 9.98e-04

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 40.35  E-value: 9.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPtvLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15330   10 LILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLP--MAALYQVLNKWTLGQVTCDLFIALDVLCCTSS 87

                         90       100
                 ....*....|....*....|.
gi 125719163 127 V--LVAMAFDRYLAICSPLKY 145
Cdd:cd15330   88 IlhLCAIALDRYWAITDPIDY 108
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
 45-144 1.10e-03

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 40.37  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  45 CGLYTIALLGNsIILFVIIIERSLHKP--MYYFLSMLSVVDLGLTITTLPTVLG----VLWFhAREISIKVCliqMFF-V 117
Cdd:cd15382    8 SVLFLIAAVGN-LTVLLILLRNRRRKRsrVNILLMHLAIADLLVTFIMMPLEIGwaatVAWL-AGDFLCRLM---LFFrA 82

                         90       100
                 ....*....|....*....|....*..
gi 125719163 118 HGFsFLESSVLVAMAFDRYLAICSPLK 144
Cdd:cd15382   83 FGL-YLSSFVLVCISLDRYFAILKPLR 108
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
 47-163 1.20e-03

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 39.94  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDlGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15091   10 VFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALAD-ALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIF 88

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 125719163 127 VLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICI 163
Cdd:cd15091   89 TLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWL 125
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
 49-146 1.46e-03

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 39.64  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  49 TIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAR-EISIKVCLIQMFFVHGFSFLESSV 127
Cdd:cd15053   12 LLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGKwYLGPILCDIYIAMDVMCSTASIFN 91

                         90
                 ....*....|....*....
gi 125719163 128 LVAMAFDRYLAICSPLKYA 146
Cdd:cd15053   92 LCAISIDRYIAVTQPIKYA 110
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
 40-146 1.72e-03

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 39.34  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  40 ISIPVCGLYTIalLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPtvLGVLWFHAREISIKVCLIQMFFVHG 119
Cdd:cd15060    5 ILLSVIIAFTI--VGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLP--LNVAYFLLGKWLFGIHLCQMWLTCD 80

                         90       100
                 ....*....|....*....|....*....
gi 125719163 120 FSFLESSVL--VAMAFDRYLAICSPLKYA 146
Cdd:cd15060   81 ILCCTASILnlCAIALDRYWAIHDPINYA 109
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 50-150 1.74e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 39.39  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  50 IALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMF-----FVHGFSFLE 124
Cdd:cd15351   13 VSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnvidTMICSSVVS 92

                         90       100
                 ....*....|....*....|....*..
gi 125719163 125 S-SVLVAMAFDRYLAICSPLKYATFLT 150
Cdd:cd15351   93 SlSFLGAIAVDRYITIFYALRYHSIMT 119
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
 50-194 2.07e-03

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 39.38  E-value: 2.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  50 IALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLgLTITTLPTVLGVLWFHAR-EISIKVCLIQMFFVHGFSFLESSVL 128
Cdd:cd15365   13 ISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDL-LYIVILPLWIDYLWNGDNwTLSGFVCIFSAFLLYTNFYTSTALL 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 125719163 129 VAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVffMFPSVMAVKSVSFQggQELSHPFCFH 194
Cdd:cd15365   92 TCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEI--CFNAVILTWEDSFH--ESSSHTLCYD 153
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 38-150 2.91e-03

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 39.06  E-value: 2.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERS---LHKPMYYFLSMLSVVDLGLTITTLPTVL-GVLWFH-AREISIKVCLI 112
Cdd:cd15355    1 VLVTAIYLALFVVGTVGNSITLYTLARKKSlqhLQSTVHYHLASLALSDLLILLLAMPVELyNFIWVHhPWAFGDAACRG 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 125719163 113 QMFFVHGFSFLESSVLVAMAFDRYLAICSPLKYATFLT 150
Cdd:cd15355   81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMS 118
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
 39-239 2.95e-03

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 38.91  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  39 WISIPV-CGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLT-----ITTLPTVLGVLWFHAreisiKVCLI 112
Cdd:cd15206    1 ELIIPLySVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAvfcmpFTLVGQLLRNFIFGE-----VMCKL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 113 QMFFVHGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQELSHPFC 192
Cdd:cd15206   76 IPYFQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGGHKCREV 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 125719163 193 FHPDIIKYTYTnpwissfwgMFLQLYLNGTDLLFILFSYVLILRTVL 239
Cdd:cd15206  156 WPNEIAEQAWY---------VFLDLMLLVIPGLVMSVAYGLISWTLL 193
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
 50-316 3.02e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 38.79  E-value: 3.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  50 IALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLgLTITTLPTVLGVLWFHAREI-SIKVCLIQMFFVHGFSFLESSVL 128
Cdd:cd14982   13 LGLLGNILALWVFLRKMKKRSPTTIYMINLALADL-LFVLTLPFRIYYYLNGGWWPfGDFLCRLTGLLFYINMYGSILFL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 129 VAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSfqggQELSHPFCFHPDIIKYTYTNPWIS 208
Cdd:cd14982   92 TCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIA----KENNSTTCFEFLSEWLASAAPIVL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163 209 SFwgMFLQLYLNgtdLLFILFSYVLILRTVLNI----VAPQKQQKALSTCVCHICAVTIFYVP---MITLSVAHRLFSST 281
Cdd:cd14982  168 IA--LVVGFLIP---LLIILVCYSLIIRALRRRskqsQKSVRKRKALRMILIVLAVFLVCFLPyhvTRILYLLVRLSFIA 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 125719163 282 PRVICSILGNMYLL------LPPVLNPIIYSLKTKVIRQAI 316
Cdd:cd14982  243 DCSARNSLYKAYRItlclasLNSCLDPLIYYFLSKTFRKRL 283
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
 47-168 3.14e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 38.77  E-value: 3.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHK--PMYYFLSMLSVVDLGLTITTLPTVLgVLWFHAREISIKVCLIQMF-FVHGFSFL 123
Cdd:cd14981   10 MFVFGVLGNLLALIVLARSSKSHKwsVFYRLVAGLAITDLLGILLTSPVVL-AVYASNFEWDGGQPLCDYFgFMMSFFGL 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 125719163 124 ESSVLV-AMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFF 168
Cdd:cd14981   89 SSLLIVcAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLI 134
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
 44-145 3.47e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 38.66  E-value: 3.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  44 VCG--LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLP-----TVLGVLWfharEISIKVCLIQMFF 116
Cdd:cd15308    5 VGGvlLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPlyvysEFQGGVW----TLSPVLCDALMTM 80

                         90       100
                 ....*....|....*....|....*....
gi 125719163 117 VHGFSFLESSVLVAMAFDRYLAICSPLKY 145
Cdd:cd15308   81 DVMLCTASIFNLCAISVDRFIAVSVPLNY 109
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
 49-160 4.97e-03

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 38.39  E-value: 4.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  49 TIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLG----------LTITTLPTVlgvlwFHAreisikvCLIQMFFVh 118
Cdd:cd14968   12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILvgalaiplaiLISLGLPTN-----FHG-------CLFMACLV- 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 125719163 119 gFSFLESSV--LVAMAFDRYLAICSPLKY-----------ATFLTDMMSFVIGLI 160
Cdd:cd14968   79 -LVLTQSSIfsLLAIAIDRYLAIKIPLRYkslvtgrrawgAIAVCWVLSFLVGLT 132
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
 54-148 5.08e-03

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 38.27  E-value: 5.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  54 GNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAR-EISIKVCLIQMFFVHGFSFLESSVLVAMA 132
Cdd:cd15306   17 GNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMwPLPLVLCPIWLFLDVLFSTASIMHLCAIS 96

                         90
                 ....*....|....*.
gi 125719163 133 FDRYLAICSPLKYATF 148
Cdd:cd15306   97 LDRYIAIKKPIQASQY 112
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
 50-185 5.15e-03

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 38.23  E-value: 5.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  50 IALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLgLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESSVLV 129
Cdd:cd15094   13 VGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADE-CFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSFTLT 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 125719163 130 AMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMAVKSVSFQGGQ 185
Cdd:cd15094   92 VMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRY 147
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
 46-167 5.68e-03

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 37.95  E-value: 5.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  46 GLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLP-----TVLGvLWFHAR-------EISIKVCLIQ 113
Cdd:cd15325    9 GFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPfsaifEILG-YWAFGRvfcniwaAVDVLCCTAS 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 125719163 114 MFfvhgfsflessVLVAMAFDRYLAICSPLKYATFLTD-------MMSFVIGLIICIRQVF 167
Cdd:cd15325   88 IM-----------SLCIISIDRYIGVSYPLRYPSIMTErrgllalLCVWVLSLVISIGPLF 137
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
 38-174 5.77e-03

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 38.01  E-value: 5.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFV 117
Cdd:cd15334    1 ILISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 125719163 118 HGFSFLESSVLVAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVM 174
Cdd:cd15334   81 ITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLF 137
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
 50-159 6.01e-03

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 37.99  E-value: 6.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  50 IALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGV-----LWFHAreisikvCLIQMFFVhgFSFLE 124
Cdd:cd15068   13 LAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIstgfcAACHG-------CLFIACFV--LVLTQ 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 125719163 125 SSV--LVAMAFDRYLAICSPLKYATFLTD-----------MMSFVIGL 159
Cdd:cd15068   84 SSIfsLLAIAIDRYIAIRIPLRYNGLVTGtrakgiiaicwVLSFAIGL 131
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
 38-163 6.96e-03

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 37.92  E-value: 6.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  38 VWISIPVCGLYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDL--GLTITTLPTVLGV--LWFHAREIsikvCLIQ 113
Cdd:cd15055    1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFlvGLLVMPFSMIRSIetCWYFGDTF----CKLH 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 125719163 114 MFFVhgFSFLESSV--LVAMAFDRYLAICSPLKYATFLTDMmsfVIGLIICI 163
Cdd:cd15055   77 SSLD--YILTSASIfnLVLIAIDRYVAVCDPLLYPTKITIR---RVKICICL 123
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
 49-150 7.52e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 37.45  E-value: 7.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  49 TIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTIT-TLPTVL--GVLWFHAREISikvCLIQMFFVHGFSFLES 125
Cdd:cd15075   12 IASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFgGLLSVVtnAVGYFNLGRVG---CVLEGFAVAFFGIAAL 88

                         90       100
                 ....*....|....*....|....*
gi 125719163 126 SVLVAMAFDRYLAICSPLKYATFLT 150
Cdd:cd15075   89 CTVAVIAVDRLFVVCKPLGTLTFQT 113
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
 50-156 7.53e-03

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 37.68  E-value: 7.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  50 IALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAR-EISIKVCLiqmFFVHGFSFLESSVL 128
Cdd:cd15052   13 ATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGVwPLPLVLCL---LWVTLDVLFCTASI 89

                         90       100       110
                 ....*....|....*....|....*....|.
gi 125719163 129 V---AMAFDRYLAICSPLKYATFLTDMMSFV 156
Cdd:cd15052   90 MhlcTISLDRYMAIRYPLRTRRNKSRTTVFL 120
7tmA_SREB1_GPR27 cd15216
super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of ...
 47-149 7.97e-03

super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320344 [Multi-domain]  Cd Length: 332  Bit Score: 37.70  E-value: 7.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLgvlwFHAREISIKV--------CLIQMFFVH 118
Cdd:cd15216   10 LLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVM----LAARRAAAAAgtppgalgCKLLAFLAA 85

                         90       100       110
                 ....*....|....*....|....*....|.
gi 125719163 119 GFSFLESSVLVAMAFDRYLAICSPLKYATFL 149
Cdd:cd15216   86 LFCFHAAFLLLGVGVTRYLAIAHHRFYAERL 116
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
 47-150 8.05e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 37.61  E-value: 8.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVHGFSFLESS 126
Cdd:cd15354   10 LGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIDNVFDSLICIS 89

                         90       100       110
                 ....*....|....*....|....*....|
gi 125719163 127 V------LVAMAFDRYLAICSPLKYATFLT 150
Cdd:cd15354   90 VvasmcsLLAIAVDRYVTIFYALRYHNIMT 119
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
 44-150 8.14e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 37.34  E-value: 8.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  44 VCGLYTIAllGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLP-----TVLGVLWFHAREIsikvCLIQmffvH 118
Cdd:cd15067    8 LFCLVTVA--GNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPfsilhEMTGGYWLFGRDW----CDVW----H 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 125719163 119 GFSFLESSV----LVAMAFDRYLAICSPLKYATFLT 150
Cdd:cd15067   78 SFDVLASTAsilnLCVISLDRYWAITDPISYPSRMT 113
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
 50-175 8.54e-03

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 37.58  E-value: 8.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  50 IALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPTVLGVLWFHAREISIKVCLIQMFFVhGFSFLESSV-L 128
Cdd:cd15402   13 VDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLM-GLSVIGSIFnI 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 125719163 129 VAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFPSVMA 175
Cdd:cd15402   92 TGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFV 138
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
 50-152 9.30e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 37.41  E-value: 9.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  50 IALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTITTLPtvLGVLWFHAREISIKVCLIQMFFVHGFSFLESSV-- 127
Cdd:cd15050   13 ITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMP--LNIVYLLESKWILGRPVCLFWLSMDYVASTASIfs 90

                         90       100
                 ....*....|....*....|....*
gi 125719163 128 LVAMAFDRYLAICSPLKYATFLTDM 152
Cdd:cd15050   91 LFILCIDRYRSVQQPLKYLKYRTKT 115
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
 47-144 9.74e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 37.10  E-value: 9.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  47 LYTIALLGNSIILFVIIIERSLHKPMYYFLSMLSVVDLGLTI-----TTLPTVLGVLWFhareiSIKVCLIQMFFVHGFS 121
Cdd:cd15979   10 IFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVfcmpfTLIPNLMGTFIF-----GEVICKAVAYLMGVSV 84

                         90       100
                 ....*....|....*....|...
gi 125719163 122 FLESSVLVAMAFDRYLAICSPLK 144
Cdd:cd15979   85 SVSTFSLVAIAIERYSAICNPLQ 107
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
 54-171 9.85e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 37.15  E-value: 9.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125719163  54 GNSIILFVIIIERSLHKP---MYYFLSMLSVVDLGLTITTLPTVL-GVLWFHAREISIKVCLIQMFFVHGF-SFLESSVL 128
Cdd:cd15356   17 GNALTIHLVLKKRSLRGLqgtVHYHLVSLALSDLLILLISVPIELyNFVWFHYPWVFGDLVCRGYYFVRDIcSYATVLNI 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 125719163 129 VAMAFDRYLAICSPLKYATFLTDMMSFVIGLIICIRQVFFMFP 171
Cdd:cd15356   97 ASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALP 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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