NCBI Conserved Domain Search

Conserved domains on [gi|282396077|ref|NP_666431|]

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olfactory receptor 727 [Mus musculus]

Protein Classification

olfactory receptor family 4 protein( domain architecture ID 11607035)

olfactory receptor family 4 protein is an odorant receptor belonging to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

26-291

4.34e-162

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 452.43 E-value: 4.34e-162

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15226    2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15226   82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd15226  162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                        250       260
                 ....*....|....*....|....*.
gi 282396077 266 SVDKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15226  242 PVDKFLAVFYTVITPLLNPIIYTLRN 267

Name

Accession

Description

Interval

E-value

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

26-291

4.34e-162

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 452.43 E-value: 4.34e-162

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15226    2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15226   82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd15226  162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                        250       260
                 ....*....|....*....|....*.
gi 282396077 266 SVDKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15226  242 PVDKFLAVFYTVITPLLNPIIYTLRN 267

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-301

8.23e-43

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 148.80 E-value: 8.23e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077   31 FSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGG 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  111 EMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKLACI 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  191 DTYVVSL--LIVADSGFLSMSsfLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSYSV 267
Cdd:pfam13853 161 DIKVNNIygLFVVTSTFGIDS--LLIVLSYGLILRTVlGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNV 238

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 282396077  268 DK----VLAVFYTIFTPILNPVIYTLRNKEVKAAMSKL 301
Cdd:pfam13853 239 PPllqiMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

27-162

5.57e-04

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 41.30 E-value: 5.57e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFlIILTVTSDSRLHTPMYFLLANLSFIDMC-VASFatPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:PHA03087  43 LIVVYSTIFFFGLVGNI-IVIYVLTKTKIKTPMDIYLLNLAVSDLLfVMTL--PFQIYYYILFQWSFGEFACKIVSGLYY 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAF 162
Cdd:PHA03087 120 IGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFV 176

Name

Accession

Description

Interval

E-value

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

26-291

4.34e-162

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 452.43 E-value: 4.34e-162

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15226    2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15226   82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd15226  162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                        250       260
                 ....*....|....*....|....*.
gi 282396077 266 SVDKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15226  242 PVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

26-291

1.14e-129

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 370.39 E-value: 1.14e-129

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15939    2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15939   82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd15939  162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                        250       260
                 ....*....|....*....|....*.
gi 282396077 266 SVDKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15939  242 PIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

25-291

1.22e-118

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 342.54 E-value: 1.22e-118

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd13954    1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd13954   81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd13954  161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTIlKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 282396077 264 SYS--VDKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd13954  241 SYSsdLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

25-291

2.32e-117

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 339.31 E-value: 2.32e-117

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15936    1 FFLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15936   81 HFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15936  161 IKLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQT 240

                        250       260
                 ....*....|....*....|....*..
gi 282396077 265 YSVDKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15936  241 FPMDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

25-298

2.29e-115

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 334.42 E-value: 2.29e-115

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15225    1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15225   81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15225  161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTIlKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 282396077 264 SYS--VDKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15225  241 SYSpeTDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

27-291

3.02e-112

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 326.32 E-value: 3.02e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15940    3 FFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTK 186
Cdd:cd15940   83 FACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 LACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSYS 266
Cdd:cd15940  163 LACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFS 242

                        250       260
                 ....*....|....*....|....*
gi 282396077 267 VDKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15940  243 EDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

25-291

6.07e-110

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 320.61 E-value: 6.07e-110

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15230    1 VPLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15230   81 AVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15230  161 LKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITIlRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 282396077 264 SYSV--DKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15230  241 SYSLdqDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

26-291

2.42e-109

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 319.02 E-value: 2.42e-109

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRL-HTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15935    2 LLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15935   82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15935  162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241

                        250       260
                 ....*....|....*....|....*..
gi 282396077 265 YSVDKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15935  242 SSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

25-298

2.10e-106

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 311.89 E-value: 2.10e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15231    1 LLLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15231   81 VSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15231  161 LKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTIlKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 282396077 264 SYS--VDKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15231  241 GYSldKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

11-301

1.20e-104

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 308.14 E-value: 1.20e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  11 EFVLLGLSSSKELQPFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERK 90
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  91 TISFEACLAQIFFVHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCG 170
Cdd:cd15943   81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 171 PNKVDSFFCDLPLVTKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVL 249
Cdd:cd15943  161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAIlRIHSSEGRRKAFSTCASHLMAVTI 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 282396077 250 FFGPCIFIYVWPFSSYSV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAMSKL 301
Cdd:cd15943  241 FYGTTLFMYLRPSSSYSLdqDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

27-291

1.37e-104

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 306.80 E-value: 1.37e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15938    3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTK 186
Cdd:cd15938   83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 LACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVrnRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSYS 266
Cdd:cd15938  163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTI--RSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFP 240

                        250       260
                 ....*....|....*....|....*
gi 282396077 267 VDKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15938  241 VDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

26-291

1.69e-103

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 303.97 E-value: 1.69e-103

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15937    2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15937   82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd15937  162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241

                        250       260
                 ....*....|....*....|....*.
gi 282396077 266 SVDKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15937  242 PMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

12-295

1.18e-102

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 302.70 E-value: 1.18e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  12 FVLLGLSSSKELQPFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKT 91
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  92 ISFEACLAQIFFVHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGP 171
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 172 NKVDSFFCDLPLVTKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLF 250
Cdd:cd15408  161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATIlRMRSAEGRHKAFSTCASHLTAVTLF 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 282396077 251 FGPCIFIYVWPFSSYSV--DKVLAVFYTIFTPILNPVIYTLRNKEVK 295
Cdd:cd15408  241 YGSLAFMYLRPSSRYSLdlDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

25-298

1.26e-102

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 302.21 E-value: 1.26e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15229    1 IFLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15229   81 FFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASM-AKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15229  161 LPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGrSKAFSTCSSHLTVVGLFYGTGFFRYLRPNS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 282396077 264 SYSV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15229  241 ASSSvlDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

25-291

1.73e-102

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 301.50 E-value: 1.73e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15237    1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15237   81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15237  161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATIlRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 282396077 264 SYSV--DKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15237  241 THSPdqDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

26-298

6.74e-102

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 300.24 E-value: 6.74e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15421    2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15421   82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15421  162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVlRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 282396077 265 YS--VDKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15421  242 HSpeQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

26-291

9.00e-102

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 299.78 E-value: 9.00e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15912    2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15912   82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15912  162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTIlRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241

                        250       260
                 ....*....|....*....|....*....
gi 282396077 265 YSVD--KVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15912  242 SSLDlnKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

12-301

7.92e-98

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 290.71 E-value: 7.92e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  12 FVLLGLSSSKELQPFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKT 91
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  92 ISFEACLAQIFFVHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGP 171
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 172 NKVDSFFCDLPLVTKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLF 250
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTIlRIRSAEGRQKAFSTCASHLTAITIF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 282396077 251 FGPCIFIYVWPFSSYS--VDKVLAVFYTIFTPILNPVIYTLRNKEVKAAMSKL 301
Cdd:cd15410  241 HGTILFMYCRPSSSYSldTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

24-298

9.18e-98

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 289.89 E-value: 9.18e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  24 QPFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFF 103
Cdd:cd15235    1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 104 VHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPL 183
Cdd:cd15235   81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 184 VTKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPF 262
Cdd:cd15235  161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVlKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 282396077 263 SSYSVDK--VLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15235  241 SSYSADKdrVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

25-291

1.10e-97

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 289.38 E-value: 1.10e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15911    1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15911   81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15911  161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTIlRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 282396077 264 SYSVD--KVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15911  241 NTSRDlnKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

27-300

2.15e-97

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 288.83 E-value: 2.15e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15411    3 LFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTK 186
Cdd:cd15411   83 LATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 LACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd15411  163 LSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTIlKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSY 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 282396077 266 SV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAMSK 300
Cdd:cd15411  243 SLgqDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

28-291

6.41e-97

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 287.43 E-value: 6.41e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  28 FLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLF 107
Cdd:cd15227    4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 108 TGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKL 187
Cdd:cd15227   84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 188 ACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSYS 266
Cdd:cd15227  164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVlRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243

                        250       260
                 ....*....|....*....|....*..
gi 282396077 267 --VDKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15227  244 slLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

26-300

1.72e-95

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 284.20 E-value: 1.72e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15419    2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15419   82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWP--F 262
Cdd:cd15419  162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTIlRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPgaV 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 282396077 263 SSYSVDKVLAVFYTIFTPILNPVIYTLRNKEVKAAMSK 300
Cdd:cd15419  242 SSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

26-291

6.94e-95

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 282.22 E-value: 6.94e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15232    2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15232   82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15232  162 LLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSIlRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSS 241

                        250       260
                 ....*....|....*....|....*....
gi 282396077 265 YSV--DKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15232  242 YSPekDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

26-300

1.94e-94

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 281.45 E-value: 1.94e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15417    2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15417   82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSAS-MAKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15417  162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKgRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 282396077 265 YS--VDKVLAVFYTIFTPILNPVIYTLRNKEVKAAMSK 300
Cdd:cd15417  242 HSqdQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

25-291

1.09e-93

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 279.19 E-value: 1.09e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15915    1 IFLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15915   81 HFLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV--RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPF 262
Cdd:cd15915  161 LKLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLllKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPS 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 282396077 263 SSYSV--DKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15915  241 SGDSLeqDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

26-298

6.50e-93

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 277.67 E-value: 6.50e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15420    2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15420   82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15420  162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAIlKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 282396077 265 YSV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15420  242 NSAeqEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

27-298

8.94e-93

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 276.97 E-value: 8.94e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15429    3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTK 186
Cdd:cd15429   83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 LACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd15429  163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAIlRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 282396077 266 SV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15429  243 SAlqEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

27-300

2.01e-92

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 276.17 E-value: 2.01e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15416    3 LFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAAT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTK 186
Cdd:cd15416   83 FGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 LACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd15416  163 LSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAIlRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSY 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 282396077 266 SVD--KVLAVFYTIFTPILNPVIYTLRNKEVKAAMSK 300
Cdd:cd15416  243 SMDqnKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

27-298

5.04e-92

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 275.10 E-value: 5.04e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFL-VERKTISFEACLAQIFFVH 105
Cdd:cd15916    3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFFH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15916   83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15916  163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAIlRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSK 242

                        250       260       270
                 ....*....|....*....|....*....|....
gi 282396077 265 YSVDKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15916  243 EALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

27-298

6.56e-92

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 274.69 E-value: 6.56e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15228    3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTK 186
Cdd:cd15228   83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 LACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd15228  163 LACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISIlKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSP 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 282396077 266 SVDKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15228  243 VLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

25-291

3.36e-90

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 270.25 E-value: 3.36e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15918    1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15918   81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15918  161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVlRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 282396077 264 SYSV--DKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15918  241 SHSAskDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

25-300

9.19e-90

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 269.67 E-value: 9.19e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15415    1 VPLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15415   81 AVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15415  161 LKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAIlRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 282396077 264 SYSVD--KVLAVFYTIFTPILNPVIYTLRNKEVKAAMSK 300
Cdd:cd15415  241 QYSLEqeKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

26-291

1.91e-89

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 268.32 E-value: 1.91e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15431    2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIhTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15431   82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFL-LTVIPVLTMPLHFCGPNVINHFFCEVQALL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15431  161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVlRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240

                        250       260
                 ....*....|....*....|....*....
gi 282396077 265 YSV--DKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15431  241 SSSdqDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

12-300

2.38e-89

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 268.92 E-value: 2.38e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  12 FVLLGLSSSKELQPFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKT 91
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  92 ISFEACLAQIFFVHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGP 171
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 172 NKVDSFFCDLPLVTKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLF 250
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVlKIRSAEGRFKAFSTCASHLTAVGLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 282396077 251 FGPCIFIYVWPFSSYSV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAMSK 300
Cdd:cd15945  241 YGTLLFMYLRPSSSYSLdtDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

26-304

4.00e-89

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 268.14 E-value: 4.00e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15414    2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15414   82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15414  162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAIlRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSS 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 282396077 265 YSV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAMSKLRGR 304
Cdd:cd15414  242 SSLdlDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRR 283

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

27-298

2.32e-88

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 265.84 E-value: 2.32e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15942    3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTK 186
Cdd:cd15942   83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 LACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd15942  163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAIlKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 282396077 266 SVDKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15942  243 PLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

27-291

2.77e-88

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 265.26 E-value: 2.77e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15947    3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTK 186
Cdd:cd15947   83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 LACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd15947  163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVlRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242

                        250       260
                 ....*....|....*....|....*...
gi 282396077 266 SVD--KVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15947  243 SQDqgKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

25-300

3.81e-88

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 265.43 E-value: 3.81e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15409    1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15409   81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15409  161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTIlKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 282396077 264 SYSV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAMSK 300
Cdd:cd15409  241 LYALdqDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

27-300

6.62e-87

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 262.26 E-value: 6.62e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15413    3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCD-LPLVT 185
Cdd:cd15413   83 FIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDdLPLLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 kLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15413  163 -LSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAIlRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 282396077 265 YSV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAMSK 300
Cdd:cd15413  242 HSLdtDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

25-300

2.24e-86

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 260.79 E-value: 2.24e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15412    1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15412   81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15412  161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAIlRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 282396077 264 SYSV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAMSK 300
Cdd:cd15412  241 EESVeqSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

12-301

8.47e-86

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 260.10 E-value: 8.47e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  12 FVLLGLSSSKELQPFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKT 91
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  92 ISFEACLAQIFFVHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGP 171
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 172 NKVDSFFCDLPLVTKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLF 250
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAIlRMRSAEGRRKAFSTCASHFTGVTLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 282396077 251 FGPCIFIYVWPFSSYSV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAMSKL 301
Cdd:cd15944  241 YGTVIFMYLRPTSVYSLdqDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

26-298

1.57e-84

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 256.31 E-value: 1.57e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHT-PMYFLLANLSFIDMCVASFATPKMLADFLV-ERKTISFEACLAQIFF 103
Cdd:cd15941    2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTlSGRTISFEGCVVQLYA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 104 VHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPL 183
Cdd:cd15941   82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 184 VTKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPF 262
Cdd:cd15941  162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVlRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 282396077 263 SSYSVDKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15941  242 SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

16-301

6.84e-84

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 254.99 E-value: 6.84e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  16 GLSSSKELQPFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFE 95
Cdd:cd15406    1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  96 ACLAQIFFVHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVD 175
Cdd:cd15406   81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 176 SFFCDLPLVTKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPC 254
Cdd:cd15406  161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSIlRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 282396077 255 IFIYVWPFSSYSVD--KVLAVFYTIFTPILNPVIYTLRNKEVKAAMSKL 301
Cdd:cd15406  241 IFMYLKPSSSSSMTqeKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

27-300

8.71e-83

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 251.96 E-value: 8.71e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15407    3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTK 186
Cdd:cd15407   83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 LACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd15407  163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITIlRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSH 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 282396077 266 SV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAMSK 300
Cdd:cd15407  243 SMdtDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

25-298

1.06e-82

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 251.53 E-value: 1.06e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15434    1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15434   81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15434  161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVlKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKN 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 282396077 264 SYS--VDKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15434  241 SVSqdQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

27-291

2.25e-81

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 247.97 E-value: 2.25e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15224    3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTK 186
Cdd:cd15224   83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 LACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWP--FS 263
Cdd:cd15224  163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVlRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPkaIS 242

                        250       260
                 ....*....|....*....|....*...
gi 282396077 264 SYSVDKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15224  243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

26-291

6.98e-81

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 246.51 E-value: 6.98e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15430    2 LLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15430   82 AMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS- 263
Cdd:cd15430  162 KLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTIlRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSk 241

                        250       260
                 ....*....|....*....|....*....
gi 282396077 264 -SYSVDKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15430  242 nAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

25-298

8.49e-81

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 246.57 E-value: 8.49e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15424    1 ILLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15424   81 LSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15424  161 LKLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVlQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 282396077 264 SYSV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15424  241 GSTPdrDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

24-301

2.50e-79

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 243.15 E-value: 2.50e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  24 QPFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFF 103
Cdd:cd15418    1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 104 VHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPL 183
Cdd:cd15418   81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 184 VTKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPF 262
Cdd:cd15418  161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAIlRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 282396077 263 SSYSV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAMSKL 301
Cdd:cd15418  241 SSHTPdrDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

25-298

4.81e-78

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 239.40 E-value: 4.81e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15234    1 PLLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15234   81 LLFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSAS-MAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15234  161 LKLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGgKYKAFSTCGSHLSVVSLFYGTGLGVYISSAV 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 282396077 264 SYSVDK--VLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15234  241 THSSRKtaVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

25-291

3.02e-77

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 237.27 E-value: 3.02e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15914    1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15914   81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15914  161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVlKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSK 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 282396077 264 SYSV--DKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15914  241 SYSLdyDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

26-298

4.66e-76

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 234.68 E-value: 4.66e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15428    2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15428   82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSAS-MAKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15428  162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTgRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 282396077 265 YS--VDKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15428  242 TSkeYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

25-291

7.58e-76

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 233.91 E-value: 7.58e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15946    1 SILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15946   81 LALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15946  161 LKLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAIlKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 282396077 264 SYSV--DKVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15946  241 NYSPerDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

25-291

2.68e-73

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 227.20 E-value: 2.68e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15913    1 ILLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15913   81 FSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15913  161 LALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVlRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 282396077 264 SYSVD--KVLAVFYTIFTPILNPVIYTLRN 291
Cdd:cd15913  241 GNSTGmqKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

27-298

4.81e-73

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 226.98 E-value: 4.81e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15432    3 LFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTK 186
Cdd:cd15432   83 LGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 LACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd15432  163 LSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVlRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNS 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 282396077 266 SVD--KVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15432  243 SHDrgKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

25-298

8.50e-73

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 226.21 E-value: 8.50e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15233    1 PVLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15233   81 HLLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYT-VILITVRNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15233  161 FQLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAhVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 282396077 264 SYSV--DKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15233  241 VYSSdkDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

27-298

1.40e-72

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 225.76 E-value: 1.40e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15405    3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTK 186
Cdd:cd15405   83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 LACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd15405  163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNIlHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 282396077 266 SVD--KVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15405  243 SVNqgKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

28-298

1.55e-68

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 215.40 E-value: 1.55e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  28 FLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLF 107
Cdd:cd15236    4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 108 TGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKL 187
Cdd:cd15236   84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 188 ACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSYS 266
Cdd:cd15236  164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATIlKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 282396077 267 VDK--VLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15236  244 SDKdiVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

25-298

1.98e-67

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 212.34 E-value: 1.98e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15433    1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15433   81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFS 263
Cdd:cd15433  161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVlRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 282396077 264 SYSVD--KVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15433  241 RYSQAhgKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

25-298

9.75e-59

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 190.20 E-value: 9.75e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15223    1 HWLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15223   81 HFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIY-VWPF 262
Cdd:cd15223  161 VSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVlRLASGEARSKALNTCGSHLIVILFFYTAVLVSSlTYRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 282396077 263 S---SYSVDKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15223  241 GktiPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

31-294

1.15e-56

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 184.80 E-value: 1.15e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  31 FSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGG 110
Cdd:cd15917    7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 111 EMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKLACI 190
Cdd:cd15917   87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 191 DTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSYSVDK 269
Cdd:cd15917  167 DTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVlQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHVPP 246

                        250       260
                 ....*....|....*....|....*....
gi 282396077 270 ----VLAVFYTIFTPILNPVIYTLRNKEV 294
Cdd:cd15917  247 hvhiLLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

31-294

1.27e-54

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 179.53 E-value: 1.27e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  31 FSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGG 110
Cdd:cd15950    7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 111 EMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKLACI 190
Cdd:cd15950   87 ESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 191 DTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSA-SMAKARSTLTAHITVVVLFFGPCIF-IYVWPFSSY--- 265
Cdd:cd15950  167 DPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKeARLKAFSTCGSHVCVILLFYIPGLLsIYTQRFGQGvpp 246

                        250       260
                 ....*....|....*....|....*....
gi 282396077 266 SVDKVLAVFYTIFTPILNPVIYTLRNKEV 294
Cdd:cd15950  247 HTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

31-294

4.13e-54

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 177.96 E-value: 4.13e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  31 FSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGG 110
Cdd:cd15952    7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 111 EMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKLACI 190
Cdd:cd15952   87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 191 DTYVVsllIVADSGFLSMSSF--LLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSYSV 267
Cdd:cd15952  167 SIRIN---IIYGLFAISVLVLdvILIALSYVLILRAVfRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNI 243

                        250       260       270
                 ....*....|....*....|....*....|.
gi 282396077 268 DK----VLAVFYTIFTPILNPVIYTLRNKEV 294
Cdd:cd15952  244 PRyihiLLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

25-294

1.03e-50

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 169.22 E-value: 1.03e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15222    1 HWISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVcIILVCISWFVGFIHTTSQLAFTVN-LPFCGPNKVDSFFCDLPL 183
Cdd:cd15222   81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSR-IAKIGLAIVLRSVLLLLPLPFLLKrLPFCHSNVLSHSYCLHQD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 184 VTKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSS-ASMAKARSTLTAHITVVVLFFGPCIFIYV--- 259
Cdd:cd15222  160 VMKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASrEERLKALNTCVSHICAVLIFYVPMIGLSMvhr 239

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 282396077 260 -WPFSSYSVDKVLAVFYTIFTPILNPVIYTLRNKEV 294
Cdd:cd15222  240 fGKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

31-294

7.28e-50

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 167.06 E-value: 7.28e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  31 FSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGG 110
Cdd:cd15953    7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 111 EMVLLVSMAYDRYVAICKPLHYMTIMSR-RVCII-LVCISWFVGFIHTTSQLAftVNLPFCGPNKVDSFFCDLPLVTKLA 188
Cdd:cd15953   87 ESAVLVAMAFDRYVAICNPLRYATILTNsRIAKLgLVGLIRGVLLILPLPLLL--SRLPFCANRIIPHTYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 189 CIDT-------YVVSLLIVadsgflsMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYV- 259
Cdd:cd15953  165 CGDTtinriygLVVALLVV-------GLDLLLIALSYALIIRAVlRLSSKKARQKALNTCTAHICVILMSYTPALFSFLt 237

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 282396077 260 WPFS---SYSVDKVLAVFYTIFTPILNPVIYTLRNKEV 294
Cdd:cd15953  238 HRFGqgiAPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

31-294

3.45e-49

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 165.54 E-value: 3.45e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  31 FSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGG 110
Cdd:cd15221    7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 111 EMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKLACI 190
Cdd:cd15221   87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 191 DTYVVSL--LIVAdsgFLSM-SSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIF-IYVWPFSSY 265
Cdd:cd15221  167 DITVNIWygLTVA---LLTVgLDVVLIAVSYALILRAVfRLPSKDARLKALSTCGSHVCVILMFYTPAFFsFLTHRFGRH 243

                        250       260       270
                 ....*....|....*....|....*....|..
gi 282396077 266 ---SVDKVLAVFYTIFTPILNPVIYTLRNKEV 294
Cdd:cd15221  244 iprHVHILLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

29-294

1.90e-47

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 160.98 E-value: 1.90e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15951    5 IPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKLA 188
Cdd:cd15951   85 TMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 189 CIDTYVVSL--LIVAdsgFLSMS-SFLLLVVSYTVILITVRN-RSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15951  165 CADTRVSRAygLSVA---FLVGGlDVIFIAVSYIQILRAVFKlPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 282396077 265 YSVDKVLAVF----YTIFTPILNPVIYTLRNKEV 294
Cdd:cd15951  242 HNVPPHVHILianvYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

26-294

5.98e-45

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 154.25 E-value: 5.98e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15956    2 WLSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15956   82 AFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15956  162 KLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVlRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 282396077 265 YSVDK----VLAVFYTIFTPILNPVIYTLRNKEV 294
Cdd:cd15956  242 HSVPSaahvLLSNLYLLLPPALNPIVYGIRTKQI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-301

8.23e-43

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 148.80 E-value: 8.23e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077   31 FSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGG 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  111 EMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKLACI 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  191 DTYVVSL--LIVADSGFLSMSsfLLLVVSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSYSV 267
Cdd:pfam13853 161 DIKVNNIygLFVVTSTFGIDS--LLIVLSYGLILRTVlGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNV 238

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 282396077  268 DK----VLAVFYTIFTPILNPVIYTLRNKEVKAAMSKL 301
Cdd:pfam13853 239 PPllqiMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

24-295

2.21e-40

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 142.74 E-value: 2.21e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  24 QPFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFF 103
Cdd:cd15948    1 HPWISIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 104 VHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVcIILVCISWFVGFIHTTSQLAFTVN-LPFCGPNKVDSFFCDLP 182
Cdd:cd15948   81 LHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSV-ITKIGLAALARAVTLMTPLPFLLRrLPYCRSHVIAHCYCEHM 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 183 LVTKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSA-SMAKARSTLTAHITVVVLFFGPCIFIYVW- 260
Cdd:cd15948  160 AVVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKeEQLKAFGTCGSHICAILVFYTPVVLSSTMh 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 282396077 261 ---PFSSYSVDKVLAVFYTIFTPILNPVIYTLRNKEVK 295
Cdd:cd15948  240 rfaRHVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

31-294

1.50e-37

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 134.95 E-value: 1.50e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  31 FSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGG 110
Cdd:cd15954    7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 111 EMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKLACI 190
Cdd:cd15954   87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 191 DTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSA-SMAKARSTLTAHITVVVLFFGPCIF-IYVWPFSSYSVD 268
Cdd:cd15954  167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKeARSKAFSTCTAHICAIVITYTPAFFtFFAHRFGGHHIT 246

                        250       260       270
                 ....*....|....*....|....*....|
gi 282396077 269 K----VLAVFYTIFTPILNPVIYTLRNKEV 294
Cdd:cd15954  247 PhihiIMANLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

10-295

6.73e-36

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 131.05 E-value: 6.73e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  10 TEFVLLGLSSSKELQPFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVER 89
Cdd:cd15949    2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  90 KTISFEACLAQIFFVHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFC 169
Cdd:cd15949   82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 170 GPNKVDSFFCDLPLVTKLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASMA-KARSTLTAHITVVV 248
Cdd:cd15949  162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARlKTFGTCVSHVCAIL 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 282396077 249 LFFGP-CIFIYVWPFS---SYSVDKVLAVFYTIFTPILNPVIYTLRNKEVK 295
Cdd:cd15949  242 AFYVPiAVSSLIHRFGqnvPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

41-287

1.95e-31

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 118.17 E-value: 1.95e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077   41 GNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFL-VERKTISFEACLAQIFFVHLFTGGEMVLLVSMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLnHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  120 YDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNkvdSFFCDLPLVTKLACIDTYVVSLLI 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSKPVSYTLLISV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  200 VadsGFLSMssFLLLVVSYTVILITVRNRSSASMA--------KARSTLTAHITVVVLFFGPCIFIYVWP------FSSY 265
Cdd:pfam00001 158 L---GFLLP--LLVILVCYTLIIRTLRKSASKQKSsertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDslaldcELSR 232

                         250       260
                  ....*....|....*....|....
gi 282396077  266 SVDKVLAV--FYTIFTPILNPVIY 287
Cdd:pfam00001 233 LLDKALSVtlWLAYVNSCLNPIIY 256

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

31-294

5.37e-31

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 117.56 E-value: 5.37e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  31 FSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGG 110
Cdd:cd15955    7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 111 EMVLLVSMAYDRYVAICKPLHYMTIMSRRVCI-ILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKLAC 189
Cdd:cd15955   87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLgIGVLVVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 190 IDTYVVSL--LIVADSGFLSMSSFLLLvvSYTVILITV-RNRSSASMAKARSTLTAHITVVVLFFGPCIF-IYVWPFSSY 265
Cdd:cd15955  167 DDVRVNKIygLFVAFSILGFDIIFITT--SYALIFRAVfRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFsFFAHRFGHH 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 282396077 266 ---SVDKVLAVFYTIFTPILNPVIYTLRNKEV 294
Cdd:cd15955  245 vapYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

27-291

3.98e-28

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 110.07 E-value: 3.98e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTk 186
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSK- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 lacidTYVVSLLIVadsGFLsmSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAH------------ITVVVLFF--- 251
Cdd:cd00637  160 -----AYTIFLFVL---LFL--LPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRrrrrerkvtktlLIVVVVFLlcw 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 282396077 252 GPCIFIYVWPFSSYSVDKVLAVFYTIFT------PILNPVIYTLRN 291
Cdd:cd00637  230 LPYFILLLLDVFGPDPSPLPRILYFLALllaylnSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

26-298

4.73e-22

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 93.01 E-value: 4.73e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIhtTSQLAFTVNLPFCGPNKVDSFFCDLPLvt 185
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLL--ISLPPLVGWRDETQPSVVDCECEFTPN-- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 klaciDTYVVSLLIVadSGFLsmsSFLLLVVSYTVILITVRNrssasmaKARSTLTAHITVVVLFFGPCIFIYVWPFSSY 265
Cdd:cd14967  157 -----KIYVLVSSVI--SFFI---PLLIMIVLYARIFRVARR-------ELKAAKTLAIIVGAFLLCWLPFFIIYLVSAF 219

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 282396077 266 SV-DKVLAVFYTIFTPI------LNPVIYTLRNKEVKAAM 298
Cdd:cd14967  220 CPpDCVPPILYAVFFWLgylnsaLNPIIYALFNRDFRRAF 259

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

30-298

2.37e-14

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 71.85 E-value: 2.37e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTG 109
Cdd:cd14969    6 YLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 110 GEMVLLVSMAYDRYVAICKPLhYMTIMSRRVCIILVCISWFVGFIHTTsqlaftvnLPFCGPNK----VDSFFCDLPLVT 185
Cdd:cd14969   86 VSISTLAALAFERYLVIVRPL-KAFRLSKRRALILIAFIWLYGLFWAL--------PPLFGWSSyvpeGGGTSCSVDWYS 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIvadsgFLSMSSFLLLVVSYTVILITVRNRS-----SASMAKARSTLTAHITVVVLFFGPCI-FIYV 259
Cdd:cd14969  157 KDPNSLSYIVSLFV-----FCFFLPLAIIIFCYYKIYRTLRKMSkraarRKNSAITKRTKKAEKKVAKMVLVMIVaFLIA 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 282396077 260 W-PFSSYSV-------DKVLAVFYTI------FTPILNPVIYTLRNKEVKAAM 298
Cdd:cd14969  232 WtPYAVVSLyvsfggeSTIPPLLATIpalfakSSTIYNPIIYVFMNKQFRRAL 284

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

38-298

1.23e-12

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 66.93 E-value: 1.23e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  38 ILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDmCVASFATPKMLADFLVERKTIS-FEACLAQIFFVHLFTGGEMVLLV 116
Cdd:cd14972   12 IVVENSLVLAAIIKNRRLHKPMYILIANLAAAD-LLAGIAFVFTFLSVLLVSLTPSpATWLLRKGSLVLSLLASAYSLLA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 117 sMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTsqlaftvnLPFCGPNKVDsffCDLPLVTKLACIDTYVVS 196
Cdd:cd14972   91 -IAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL--------LPVLGWNCVL---CDQESCSPLGPGLPKSYL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 197 LLIVAdsgFLSMsSFLLLVVSYTVILITVRNRSSASMAKARSTLTAH--------ITVVVLFfgpCIFIYVW-PFSSY-- 265
Cdd:cd14972  159 VLILV---FFFI-ALVIIVFLYVRIFWCLWRHANAIAARQEAAVPAQpstsrklaKTVVIVL---GVFLVCWlPLLILlv 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 282396077 266 ------SVDKVLAVFY-----TIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd14972  232 ldvlcpSVCDIQAVFYyflvlALLNSAINPIIYAFRLKEMRRAV 275

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

33-297

3.57e-12

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 65.74 E-value: 3.57e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  33 LLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPkmLADFLVERKTISFEACLAQIFFVHLFTGGEM 112
Cdd:cd14968    9 LIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLVLVLTQSSI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 113 VLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIhttsqLAFTvnlPFCGPNKVDSfFCDLPLVTKLACIDT 192
Cdd:cd14968   87 FSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFL-----VGLT---PMFGWNNGAP-LESGCGEGGIQCLFE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 193 YVVSLLIVADSGFLS--MSSFLLLVVSYTVILITVRN-----RSSASMAKARSTLTAHI------TVVVLFFGPC----- 254
Cdd:cd14968  158 EVIPMDYMVYFNFFAcvLVPLLIMLVIYLRIFRVIRKqlrqiESLLRSRRSRSTLQKEVkaakslAIILFLFALCwlplh 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 282396077 255 ---IFIYVWPfsSYSVDKVL---AVFYTIFTPILNPVIYTLRNKEVKAA 297
Cdd:cd14968  238 iinCITLFCP--ECKVPKILtyiAILLSHANSAVNPIVYAYRIRKFRQT 284

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

27-287

1.48e-11

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 64.00 E-value: 1.48e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15012    2 FIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSffcdlplvTK 186
Cdd:cd15012   82 SYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQE--------EE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 LACIDTYVVSLLIVADSGFLS--MSSFLLLVVSYTVILITVrnrSSASMAKARSTLTAHITVVVLFFGPCIF-IYVWPFS 263
Cdd:cd15012  154 ICVLDREMFNSKLYDTINFIVwyLIPLLIMTVLYSKISIVL---WKSSSIEARRKVVRLLVAVVVSFALCNLpYHARKMW 230

                        250       260
                 ....*....|....*....|....*.
gi 282396077 264 SYSVD--KVLAVFYTIFTPILNPVIY 287
Cdd:cd15012  231 QYWSEpyRCDSNWNALLTPLTFLVLY 256

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

26-151

3.40e-11

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 62.96 E-value: 3.40e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSfidmcvasfatpkmLADFLVERKTISFEA--------- 96
Cdd:cd15055    2 LLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLA--------------VADFLVGLLVMPFSMirsietcwy 67

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  97 -----CLAQIFFVHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFV 151
Cdd:cd15055   68 fgdtfCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFV 127

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

26-297

1.22e-10

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 60.84 E-value: 1.22e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15061    1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTsqlaftvnLPFCGPNKvdSFFCDLplvt 185
Cdd:cd15061   81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITS--------PPLVGPSW--HGRRGL---- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 kLACIDTYVVSLLIvadsgFLSMSSFLLLVvsytVILITVRNRSSASMAKARSTLTAhITVVVLFFGPC-----IFIYVW 260
Cdd:cd15061  147 -GSCYYTYDKGYRI-----YSSMGSFFLPL----LLMLFVYLRIFRVIAKERKTAKT-LAIVVGCFIVCwlpffIMYLIE 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 282396077 261 PFSSYSVDKVLAVFYT---IFTPILNPVIYTLRNKEVKAA 297
Cdd:cd15061  216 PFCDCQFSEALSTAFTwlgYFNSVINPFIYAFYNKDFRRA 255

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

26-287

1.25e-10

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 61.10 E-value: 1.25e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLAdflverktISFEACL-AQIFFV 104
Cdd:cd15314    2 LLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMV--------RSVETCWyFGDLFC 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVL-------LVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIhttsqlaFTVNLPFCGPNKVDSF 177
Cdd:cd15314   74 KIHSSFDITLctasilnLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSAL-------VGFGIIFLELNIKGIY 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 178 FCDLPLVTKlaCIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILI------------TVRNRSSASM-AKARSTLTAHI 244
Cdd:cd15314  147 YNHVACEGG--CLVFFSKVSSVVGSVFSFYIPAVIMLCIYLKIFLVaqrqarsiqsarTKSGASSSKMeRKATKTLAIVM 224

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 282396077 245 TVVVLFFGP---CIFIYvwPFSSYSVDKVLAVFYTIFT---PILNPVIY 287
Cdd:cd15314  225 GVFLLCWTPfflCNIID--PFINYSIPPVLIEVLNWLGysnSTLNPFIY 271

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

29-251

5.03e-10

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 59.61 E-value: 5.03e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEA-CLAQIFFVHLF 107
Cdd:cd14997    5 VVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWLLGEFmCKLVPFVELTV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 108 TGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVnlpfcgpNKVDSFFCDLPLVTKL 187
Cdd:cd14997   85 AHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITE-------FKEEDFNDGTPVAVCR 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 282396077 188 ACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVI----LITVRNRSSASMAKARSTLTAH-------ITVVVLFF 251
Cdd:cd14997  158 TPADTFWKVAYILSTIVVFFVVPLAILSGLYSVIcrrlVGHPALESRRADAANRHTLRSRrqvvymlITVVVLFF 232

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

32-260

1.52e-09

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 57.63 E-value: 1.52e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  32 SLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFAT-PKMLADFlverkTISFEACLAQIFFVHLFTGG 110
Cdd:cd15196    8 ATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVlPQLIWDI-----TYRFYGGDLLCRLVKYLQVV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 111 EMVL----LVSMAYDRYVAICKPLHYMTIMSRRVcIILVCISWFVGFIHTTSQLaFTVNLPFCGPNKVDSFFCDLPLVTK 186
Cdd:cd15196   83 GMYAssyvLVATAIDRYIAICHPLSSHRWTSRRV-HLMVAIAWVLSLLLSIPQL-FIFSYQEVGSGVYDCWATFEPPWGL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 282396077 187 LACIDTYVVSLLIVadsgflsmsSFLLLVVSYTVILITVRNrssasmAKARsTLTAHITVVVLFF---GPCIFIYVW 260
Cdd:cd15196  161 RAYITWFTVAVFVV---------PLIILAFCYGRICYVVWR------AKIK-TVKLTLVVVACYIvcwTPFFVVQMW 221

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

30-182

1.94e-09

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 57.61 E-value: 1.94e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAI----LLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd14993    2 VLIVLYVVVfllaLVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQG 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMS-RRVCIILVCIsWFVgfihttsqlAFTVNLPFCGPNKVDSFFCDLP 182
Cdd:cd14993   82 VSVSASVLTLVAISIDRYLAICYPLKARRVSTkRRARIIIVAI-WVI---------AIIIMLPLLVVYELEEIISSEP 149

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

27-165

2.06e-09

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 57.46 E-value: 2.06e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDM----CVASFATPKML------ADFLVERKT-ISFE 95
Cdd:cd15317    3 IYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFllglCVMPFSMIRTVetcwyfGDLFCKFHTgLDLL 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  96 ACLAQIFfvhlftggemvLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVN 165
Cdd:cd15317   83 LCTTSIF-----------HLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGAN 141

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

29-297

3.15e-09

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 56.80 E-value: 3.15e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15978    5 LLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKLA 188
Cdd:cd15978   85 SVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINNSTGNMCRLLWPNDVT 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 189 CIDTYVVSLLIvadsgfLSMSSFLLLVVSYTVILITVRNRSSASMAKARsTLTAHITVVVLFF---GPCIFIYVW-PFSS 264
Cdd:cd15978  165 QQSWYIFLLLI------LFLIPGIVMMTAYGLISLELYRGIKFLMAKKR-VIRMLIVIVILFFlcwTPIFSANAWrAFDT 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 282396077 265 YSVDKVLAVFYTIFTPIL-------NPVIYTLRNKEVKAA 297
Cdd:cd15978  238 RSADRLLSGAPISFIHLLsytsacvNPIIYCFMNKRFRMG 277

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

26-292

3.15e-09

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 56.92 E-value: 3.15e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15390    2 LWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMtiMSRRVCIILVCISWFVgfihttsqlAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15390   82 TTVAASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLA---------SFLLALPQLLYSTTETYYYYTGSER 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYV---VSLLIVADSGFLSMSSFL---LLVVSYTVILITVR--------NRSSASMAKARSTLTAHITVVVLFF 251
Cdd:cd15390  151 TVCFIAWPDgpnSLQDFVYNIVLFVVTYFLpliIMAVAYTRVGVELWgsktigenTPRQLESVRAKRKVVKMMIVVVVIF 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 282396077 252 GPC------IFIYVW-PFSSYSVDKVLAVFYTIF-----TPILNPVIYTLRNK 292
Cdd:cd15390  231 AICwlpyhlYFILTYlYPDINSWKYIQQIYLAIYwlamsNSMYNPIIYCWMNK 283

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

32-150

5.22e-09

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 56.70 E-value: 5.22e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  32 SLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEA-CLAQIFFVHLFTGG 110
Cdd:cd15005    8 GLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIYGALsCKVIAFLAVLFCFH 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 282396077 111 EMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWF 150
Cdd:cd15005   88 SAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWT 127

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

29-153

8.64e-09

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 55.40 E-value: 8.64e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATP-KMLADFLVERKTISFEACLAQIFFVHLF 107
Cdd:cd15052    5 LLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDVLF 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 282396077 108 TGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGF 153
Cdd:cd15052   85 CTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISI 130

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

26-297

8.92e-09

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 55.41 E-value: 8.92e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15064    2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSqlaftvnlPFCGPNKVDSffcdlplVT 185
Cdd:cd15064   82 TCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLP--------PLFGWRTPDS-------ED 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRssasmaKARSTLTAHITVVVL----FFgpcIFIYVWP 261
Cdd:cd15064  147 PSECLISQDIGYTIFSTFGAFYIPLLLMLILYWKIYRAAARER------KAAKTLGIILGAFIVcwlpFF---LVALIVP 217

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 282396077 262 FSSYS-VDKVLAVFYT---IFTPILNPVIYTLRNKEVKAA 297
Cdd:cd15064  218 LCSHCwIPLALKSFFLwlgYFNSLINPLIYTFFNKDFRKA 257

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

39-283

1.36e-08

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 55.33 E-value: 1.36e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  39 LLGNFLIILTVTSDsRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQI-----FFVHLFTGGEMV 113
Cdd:cd14978   15 IIGNILNLVVLTRK-SMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFlpyiyPLANTFQTASVW 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 114 LLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKlacIDTY 193
Cdd:cd14978   94 LTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLRQ---NETY 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 194 VVSLLIVADSGFLSMSSFLLLVVSYTVILITVR--NRSSASMAKARSTLTAH-----------ITVVVLFF---GPCIFI 257
Cdd:cd14978  171 LLKYYFWLYAIFVVLLPFILLLILNILLIRALRksKKRRRLLRRRRRLLSRSqrrerrttimlIAVVIVFLicnLPAGIL 250

                        250       260
                 ....*....|....*....|....*.
gi 282396077 258 YVWpfSSYSVDKVLAVFYTIFTPILN 283
Cdd:cd14978  251 NIL--EAIFGESFLSPIYQLLGDISN 274

7tmA_Mel1

cd15209

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...

25-149

1.41e-08

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320337 [Multi-domain] Cd Length: 279 Bit Score: 54.78 E-value: 1.41e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15209    1 SALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIM 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISW 149
Cdd:cd15209   81 GLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTW 125

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

29-292

2.57e-08

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 53.93 E-value: 2.57e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15206    5 PLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNkvdSFFCDLPLVTKLA 188
Cdd:cd15206   85 SVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPG---GHKCREVWPNEIA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 189 CIDTYVVSLLIvadsgfLSMSSFLLLVVSYTVILITVRnrssasMAKARsTLTAHITVVVLFF---GPCIFIYVWpfssY 265
Cdd:cd15206  162 EQAWYVFLDLM------LLVIPGLVMSVAYGLISWTLL------EAKKR-VIRMLFVIVVEFFicwTPLYVINTW----K 224

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 282396077 266 SVDKVLAVFYTIFTPI------------LNPVIYTLRNK 292
Cdd:cd15206  225 AFDPPSAARYVSSTTIsliqllayisscVNPITYCFMNK 263

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

27-154

4.99e-08

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 53.51 E-value: 4.99e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPkmladFLVERktiSFEAC-LAQIFFVH 105
Cdd:cd15312    3 MYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMP-----YSMVR---SVESCwYFGDLFCK 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 282396077 106 LFTGGEMVL-------LVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15312   75 IHSSLDMMLsttsifhLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCL 130

7tm_GPCRs

cd14964

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

27-257

7.41e-08

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410628 [Multi-domain] Cd Length: 267 Bit Score: 52.82 E-value: 7.41e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd14964    1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAF-TVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd14964   81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGkGAIPRYNTLTGSCYLICTTIYLT 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 282396077 186 KLACIDTYVVSLLIVadsGFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFGPCIFI 257
Cdd:cd14964  161 WGFLLVSFLLPLVAF---LVIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVF 229

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

25-151

1.01e-07

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 52.45 E-value: 1.01e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15058    1 PGLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFV 151
Cdd:cd15058   81 VLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIV 127

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

29-149

1.14e-07

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 51.99 E-value: 1.14e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15066    4 FAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFS 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISW 149
Cdd:cd15066   84 TASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVW 124

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

26-149

1.60e-07

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 51.50 E-value: 1.60e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15329    2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDV 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISW 149
Cdd:cd15329   82 LLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVW 125

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

27-176

1.70e-07

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 51.86 E-value: 1.70e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAillGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPkmLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15069    6 LELIIAALSVA---GNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIP--FAITISLGFCTDFHSCLFLACFVLV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFvgfihttsqLAFTVNL-PFCGPNKVDS 176
Cdd:cd15069   81 LTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWV---------LAFGIGLtPFLGWNKAMS 142

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

39-154

2.78e-07

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 51.18 E-value: 2.78e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  39 LLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGGEMVLLVSM 118
Cdd:cd15083   15 VVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLAAI 94

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 282396077 119 AYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15083   95 AVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLL 130

7tmA_Histamine_H3R_H4R

cd15048

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...

26-153

3.04e-07

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320176 [Multi-domain] Cd Length: 296 Bit Score: 51.15 E-value: 3.04e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15048    2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGF 153
Cdd:cd15048   82 TLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAF 129

7tmA_leucokinin-like

cd15393

leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...

30-258

3.45e-07

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.

Pssm-ID: 320515 [Multi-domain] Cd Length: 288 Bit Score: 50.87 E-value: 3.45e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAI----LLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15393    2 LLSILYGIIslvaVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHymTIMSRRVCIILVCISWFVGFIHTTSQ-LAFTVNLPFCGPNKVDSFFCdLPLV 184
Cdd:cd15393   82 LSVNVSVFTLTVIAVDRYRAVIHPLK--ARCSKKSAKIIILIIWILALLVALPVaLALRVEELTDKTNNGVKPFC-LPVG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVadsgflsmSSFL-LLVVSYTVILITVRNRSS-----------ASMAKARSTLTAHITVVVLFFG 252
Cdd:cd15393  159 PSDDWWKIYNLYLVCV--------QYFVpLVIICYAYTRIAVKIWGTkapgnaqdvrdDEILKNKKKVIKMLIIVVALFA 230


                 ....*.
gi 282396077 253 PCIFIY 258
Cdd:cd15393  231 LCWLPL 236

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

29-297

4.14e-07

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 50.45 E-value: 4.14e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRL-HTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLF 107
Cdd:cd15104    4 VILAVLSPLIITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 108 TGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVtkl 187
Cdd:cd15104   84 CAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGKCSFFAAFHPRV--- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 188 acidtyvvsLLIVADSGFLsmSSFLLLVVSYTVILITVRNRSSA------------------SMAKARSTLTAHITVVVL 249
Cdd:cd15104  161 ---------LLVLSCMVFF--PALLLFVFCYCDILKIARVHSRAiykvehalarqihprrtlSDFKAARTVAVLIGCFLL 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 282396077 250 FFGPCIFIYVWPFSS-----YSVDKVLAVFYTIFTPILNPVIYTLRNKEVKAA 297
Cdd:cd15104  230 SWLPFQITGLVQALCdecklYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRA 282

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

26-153

4.81e-07

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 50.43 E-value: 4.81e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15065    1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGF 153
Cdd:cd15065   81 MCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSA 128

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

29-154

4.93e-07

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 50.43 E-value: 4.93e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERK-TISFEACLAQIFFVHLF 107
Cdd:cd14979    5 AIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPwAFGDGGCKLYYFLFEAC 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 282396077 108 TGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd14979   85 TYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSIL 131

7tmA_mAChR_M1

cd17790

muscarinic acetylcholine receptor subtype M1, member of the class A family of ...

26-295

5.61e-07

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341356 [Multi-domain] Cd Length: 262 Bit Score: 49.97 E-value: 5.61e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd17790    2 LIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNlpFCGPNKVDSFFCDLPLVT 185
Cdd:cd17790   82 VASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQY--LVGERTVLAGQCYIQFLS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KlaCIDTYVVsllivadsgflSMSSFlLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFGPC-IFIYVWPFSS 264
Cdd:cd17790  160 Q--PIITFGT-----------AIAAF-YLPVTIMIILYWRIYRETIKEKKAARTLSAILLAFILTWTPYnIMVLVSTFCK 225

                        250       260       270
                 ....*....|....*....|....*....|....
gi 282396077 265 YSVDKV---LAVFYTIFTPILNPVIYTLRNKEVK 295
Cdd:cd17790  226 DCVPKTlweLGYWLCYVNSTVNPMCYALCNKSFR 259

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

26-154

5.80e-07

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 50.30 E-value: 5.80e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVER--------KTISFEAC 97
Cdd:cd15203    2 ILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNwpfgsilcKLVPSLQG 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 282396077  98 LAqiFFVHLFTggemvlLVSMAYDRYVAICKPLHymTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15203   82 VS--IFVSTLT------LTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLL 128

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

28-154

5.90e-07

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 50.12 E-value: 5.90e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  28 FLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFAtpkMLADfLVERKTISFEA----CLAQIFF 103
Cdd:cd15197    4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLIN---VLTD-IIWRITVEWRAgdfaCKVIRYL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 282396077 104 VHLFTGGEMVLLVSMAYDRYVAICKPLHYMTimSRRVCIILVCISWFVGFI 154
Cdd:cd15197   80 QVVVTYASTYVLVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILSAL 128

7tmA_Gal1_R

cd15098

galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...

29-297

7.22e-07

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320226 [Multi-domain] Cd Length: 282 Bit Score: 49.72 E-value: 7.22e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILT---VTSDSRLHTPMYFLL----ANLSFIDMCVASFATPKMLADFLverktisFEACLAQi 101
Cdd:cd15098    5 VVFGLIFCLGVLGNSLVITVlarVKPGKRRSTTNVFILnlsiADLFFLLFCVPFQATIYSLPEWV-------FGAFMCK- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 102 fFVHLFTGGEMVL----LVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIhTTSQLAFTVNLpFCGPNKVDSF 177
Cdd:cd15098   77 -FVHYFFTVSMLVsiftLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLA-MASPVAVHQDL-VHHWTASNQT 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 178 FCdLPLVTKLACIDTYVVSLLIVadsGFLsmSSFLLLVVSYTVIL----ITVRNRSSASMAKARSTlTAHITVVVLFFGP 253
Cdd:cd15098  154 FC-WENWPEKQQKPVYVVCTFVF---GYL--LPLLLITFCYAKVLnhlhKKLKNMSKKSERSKKKT-AQTVLVVVVVFGI 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 282396077 254 CIF----IYVW------PFSSYS-VDKVLAVFYTIFTPILNPVIYTLRNKEVKAA 297
Cdd:cd15098  227 SWLphhiIHLWvefgdfPLTQASfVLRITAHCLAYANSCVNPIIYAFLSENFRKA 281

7tmA_AstA_R_insect

cd15096

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...

29-154

7.73e-07

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320224 [Multi-domain] Cd Length: 284 Bit Score: 49.60 E-value: 7.73e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTA 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15096   85 YASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILV 130

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

39-145

8.50e-07

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 49.72 E-value: 8.50e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  39 LLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGGEMVLLVSM 118
Cdd:cd15336   15 MLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITLLAI 94

                         90       100
                 ....*....|....*....|....*...
gi 282396077 119 AYDRYVAICKPLHYMTIMS-RRVCIILV 145
Cdd:cd15336   95 SLDRYLVITKPLASIRWVSkKRAMIIIL 122

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

26-150

1.10e-06

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 49.50 E-value: 1.10e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVAsFATPKMLADFLVERKTISFEAClaQIF-FV 104
Cdd:cd15079    2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMM-IKMPIFIYNSFYEGWALGPLGC--QIYaFL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 282396077 105 HLFTG-GEMVLLVSMAYDRYVAICKPLHyMTIMSRRVCIILVCISWF 150
Cdd:cd15079   79 GSLSGiGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWL 124

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

28-219

1.14e-06

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 49.20 E-value: 1.14e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  28 FLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAqIFFVHLF 107
Cdd:cd15001    3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKA-VAYLQLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 108 TGGEMVL-LVSMAYDRYVAICKPLHYMTI-MSRRVCIILVCIsWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVT 185
Cdd:cd15001   82 SFICSVLtLTAISIERYYVILHPMKAKSFcTIGRARKVALLI-WILSAILASPVLFGQGLVRYESENGVTVYHCQKAWPS 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 282396077 186 KLACIDtYVVSLLIVadsgfLSMSSFLLLVVSYT 219
Cdd:cd15001  161 TLYSRL-YVVYLAIV-----IFFIPLIVMTFAYA 188

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

25-254

1.18e-06

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 49.35 E-value: 1.18e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15394    1 PLIIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRGWVFGRFMCYFVFLM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVL-LVSMAYDRYVAICKPLHYMtiMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGpnkVDSFFCDLPL 183
Cdd:cd15394   81 QPVTVYVSVFtLTAIAVDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKG---LDFSICEEFW 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 184 VTKLACIDTYVVSLLIVAdsgflSMSSFLLLVVSYTVILITVRNR--------SSASMAKARSTLTAHI-TVVVLFFGPC 254
Cdd:cd15394  156 FGQEKQRLAYACSTLLIT-----YVLPLLAISLSYLRISVKLRNRvvpgsmtqSQAEWDRARRRKTFRLlVVVVVAFAIC 230

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

29-251

1.26e-06

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 49.04 E-value: 1.26e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15979    5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKLA 188
Cdd:cd15979   85 SVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQCRHAWPSAQV 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 282396077 189 CIDTYVVSLLIvadsgfLSMSSFLLLVVSYTVIlitVRNRSSASMAKARsTLTAHITVVVLFF 251
Cdd:cd15979  165 RQAWYVLLLLI------LFFIPGVVMIVAYGLI---SRELYRGLLAKKR-VIRMLVVIVAMFF 217

7tmA_TACR_family

cd14992

tachykinin receptor and closely related proteins, member of the class A family of ...

39-251

1.39e-06

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320123 [Multi-domain] Cd Length: 291 Bit Score: 48.97 E-value: 1.39e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  39 LLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGGEMVLLVSM 118
Cdd:cd14992   15 VVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAI 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 119 AYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLP-FCGPNKVDSFFCDLPLVTKLACIDTYVVSL 197
Cdd:cd14992   95 AFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVlFSVKNQEKIFCCQIPPVDNKTYEKVYFLLI 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 282396077 198 LIVadsgfLSMSSFLLLVVSYTVILITVRNRSSAS----------MAKARSTLTAHITVVVLFF 251
Cdd:cd14992  175 FVV-----IFVLPLIVMTLAYARISRELWFRKVPGfsikeverkrLKCKRRVIKMLVCVVVLFV 233

7tmA_alpha2B_AR

cd15321

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

30-297

1.67e-06

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320444 [Multi-domain] Cd Length: 268 Bit Score: 48.76 E-value: 1.67e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTG 109
Cdd:cd15321   12 AITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCT 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 110 GEMVLLVSMAYDRYVAICKPLHYMTIMS-RRV-CIILVC--ISWFVGF---IHTTSQLAFTVNLPFCGPNKVDSFfcdlp 182
Cdd:cd15321   92 SSIVHLCAISLDRYWSVSRAIEYNSKRTpRRIkCIILIVwlIAAVISLpplIYKGKQKDEQGGLPQCKLNEEAWY----- 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 183 lvtklacidtyvvsllIVADSGFLSMSSFLLLVVSYTVILITVRNRSSasmaKARSTLTAHITVVVLFFGPCIFIY---- 258
Cdd:cd15321  167 ----------------ILSSSIGSFFAPCLIMILVYLRIYLIAKNREK----RFTFVLAVVIGVFVLCWFPFFFSYslga 226

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 282396077 259 VWPFSSYSVDKVLAVFYTI--FTPILNPVIYTLRNKEVKAA 297
Cdd:cd15321  227 ICPELCKVPHSLFQFFFWIgyCNSSLNPVIYTIFNQDFRRA 267

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

27-151

1.83e-06

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 48.51 E-value: 1.83e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPkMLADFLVERKTISFEACLAQIF--FV 104
Cdd:cd15067    2 LGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMP-FSILHEMTGGYWLFGRDWCDVWhsFD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFV 151
Cdd:cd15067   81 VLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWIC 127

7tmA_Pinopsin

cd15084

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...

42-301

2.04e-06

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320212 [Multi-domain] Cd Length: 295 Bit Score: 48.71 E-value: 2.04e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  42 NFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGGEMVLLVSMAYD 121
Cdd:cd15084   28 NGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVGLWSLAILAFE 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 122 RYVAICKPLHYMTiMSRRVCIILVCISWFVGFIHTTSQL-AFTVNLP-----FCGPNkvdsffcdlpLVTKLACIDTYVV 195
Cdd:cd15084  108 RYLVICKPMGDFR-FQQRHAVSGCAFTWGWSLLWTSPPLfGWSSYVPeglrtSCGPN----------WYTGGTNNNSYIL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 196 SLLIVADSGFLSMssfllLVVSYTVILITVR-----NRSSASMAKARSTLTAHITVVVLFFGPCIFIY------VWPFSS 264
Cdd:cd15084  177 ALFVTCFALPLST-----IIFSYSNLLLTLRavaaqQKESETTQRAEKEVTRMVIAMVMAFLICWLPYatfamvVATNKD 251

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 282396077 265 YSVDKVLAVFYTIFTP---ILNPVIYTLRNKEVKAAMSKL 301
Cdd:cd15084  252 VVIQPTLASLPSYFSKtatVYNPIIYVFMNKQFRSCLLEL 291

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

32-299

2.51e-06

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 47.98 E-value: 2.51e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  32 SLLYLAILL----GNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERK-TISFEACLAQIFFVHL 106
Cdd:cd15305    4 ALLILIIIIltigGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAwPLPRYLCPIWISLDVL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWfvgfihtTSQLAFTVNLPFCGPNKVDSFFcdlplvtk 186
Cdd:cd15305   84 FSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVW-------TISIGISMPIPVIGLQDDEKVF-------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 lacidtyVVSLLIVADSGFLSMSSFLLLVVSYTVILIT------VRNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVW 260
Cdd:cd15305  149 -------VNGTCVLNDENFVLIGSFVAFFIPLIIMVITycltiqVLQRQQAINNERRASKVLGIVFFLFLIMWCPFFITN 221

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 282396077 261 PFSSYS--------VDKVLAVFYTI--FTPILNPVIYTLRNKEVKAAMS 299
Cdd:cd15305  222 ILSVLCkeacdqklMEELLNVFVWVgyVSSGINPLVYTLFNKTYRRAFS 270

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

30-150

2.67e-06

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 48.01 E-value: 2.67e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIF------F 103
Cdd:cd15354    6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIdnvfdsL 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 282396077 104 VHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMS-RRVCIILVCISWF 150
Cdd:cd15354   86 ICISVVASMCSLLAIAVDRYVTIFYALRYHNIMTvRRAGIIIACIWTF 133

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

27-250

2.84e-06

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 47.89 E-value: 2.84e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15202    3 LIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYC 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTimSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCdLPLVTK 186
Cdd:cd15202   83 SVHVSAYTLTAIAVDRYQAIMHPLKPRI--SKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLC-LEDWPE 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 282396077 187 LACIDTYVVSLLIVADSGFLSMssfLLLVVSYTVILITVR----------NRSSASMAKARSTLTAHITVVVLF 250
Cdd:cd15202  160 RADLFWKYYDLALFILQYFLPL---LVISFAYARVGIKLWasnmpgdattERYFALRRKKKKVIKMLMVVVVLF 230

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

29-250

3.58e-06

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 47.74 E-value: 3.58e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATP-KMLADFLVERKTISFEACLAQIF----- 102
Cdd:cd15392    5 LMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPfSFIALLILQYWPFGEFMCPVVNYlqavs 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 103 -FVHLFTggemvlLVSMAYDRYVAICKPLHYMtiMSRRVCIILVCISWFVGFI---------HTTSQLAFTVNLPFCGpn 172
Cdd:cd15392   85 vFVSAFT------LVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALAtalpiaitsRLFEDSNASCGQYICT-- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 173 KVDSFFCDLPLVTKLACIDTYVVSLLIvadsgflsmssfllLVVSYTVILITVRNRSSASMAKA----------RSTLTA 242
Cdd:cd15392  155 ESWPSDTNRYIYSLVLMILQYFVPLAV--------------LVFTYTRIGIVVWAKRTPGEAENnrdqrmaeskRKLVKM 220


                 ....*...
gi 282396077 243 HITVVVLF 250
Cdd:cd15392  221 MITVVAIF 228

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

27-157

3.89e-06

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 47.55 E-value: 3.89e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15318    3 IYLACAIGMLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTT 157
Cdd:cd15318   83 FCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTS 133

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

30-147

3.94e-06

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 47.48 E-value: 3.94e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQ--------I 101
Cdd:cd15103    6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQhidnvidsM 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 282396077 102 FFVHLFtgGEMVLLVSMAYDRYVAICKPLHYMTIMS-RRVCIILVCI 147
Cdd:cd15103   86 ICSSLL--ASICSLLAIAVDRYITIFYALRYHSIMTvRRAGVIITAI 130

7tmA_NPR-like_invertebrate

cd15391

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...

25-296

4.15e-06

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.

Pssm-ID: 320513 [Multi-domain] Cd Length: 289 Bit Score: 47.51 E-value: 4.15e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15391    1 PHLINLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCisWFVGFIHTTSQLAFTVNLPFCGPNKvDSFFCDLPLV 184
Cdd:cd15391   81 LVSVTASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIASI--WAISFSLSSVQLFAGRTQRYGQYSE-GRVLCGESWP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIVadsgfLSMSSFLLLVVSYTVILITVRNRSSASMA---------KARSTLTAHITVVVLFFGPC- 254
Cdd:cd15391  158 GPDTSRSAYTVFVMLL-----TYIIPLLILTSTYGYVGFRLWNRTAPGNAdkgrddmqiKSKRKVIKMLVFVVLMFGICw 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 282396077 255 ----IFIYVWPFSSYSVDK----VLAVFYTIF-----TPILNPVIYTLRNKEVKA 296
Cdd:cd15391  233 lplhLFNLVQDFSTVFRNMpqhtTRLIYGACHwiamsNSFVNPIIYLFMNDSFRS 287

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

32-161

4.64e-06

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 47.37 E-value: 4.64e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  32 SLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFA-TPKMLADFLVERKTISFEACLA---QIFFVHLF 107
Cdd:cd14986    8 GVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTvLTQIIWEATGEWVAGDVLCRIVkylQVVGLFAS 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 282396077 108 TggemVLLVSMAYDRYVAICKPLHymTIMSRRVCIILVCISWFVGFIHTTSQLA 161
Cdd:cd14986   88 T----YILVSMSLDRYQAIVKPMS--SLKPRKRARLMIVVAWVLSFLFSIPQLV 135

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

29-254

5.06e-06

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 47.08 E-value: 5.06e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd14971    5 LFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSM 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWfVGFIHTTSQLAF--TVNLPFCGPNKVDSFFCDLPLVTK 186
Cdd:cd14971   85 HASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIW-VVSLAVAAPVLAlhRLRNYTPGNRTVCSEAWPSRAHRR 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 282396077 187 LACIDTYVVSLLIvadsgflsmsSFLLLVVSYTVIL-----ITVRNRSSASMAKARSTLTAHITVVVLFFGPC 254
Cdd:cd14971  164 AFALCTFLFGYLL----------PLLLICVCYAAMLrhlwrVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAAC 226

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

27-153

5.86e-06

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 47.04 E-value: 5.86e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15050    3 LGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGF 153
Cdd:cd15050   83 ASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSF 129

7tmA_Mel1C

cd15401

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...

39-295

6.68e-06

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320523 [Multi-domain] Cd Length: 279 Bit Score: 46.83 E-value: 6.68e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  39 LLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGGEMVLLVSM 118
Cdd:cd15401   15 VLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIGSVFNITAI 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 119 AYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLaftvnlpFCGPNKVDS--FFCDLPLVTKLACIDTYVVS 196
Cdd:cd15401   95 AINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPNF-------FVGSLQYDPriYSCTFAQTVSSSYTITVVVV 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 197 LLIVAdsgfLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLF------FGPCIFIYV----------- 259
Cdd:cd15401  168 HFIVP----LSIVTFCYLRIWVLVIQVKHRVRQDSKQKLKANDIRNFLTMFVVFvlfavcWGPLNFIGLavainplkvap 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 282396077 260 ----WPFssysvdkVLAVFYTIFTPILNPVIYTLRNKEVK 295
Cdd:cd15401  244 kipeWLF-------VLSYFMAYFNSCLNAVIYGVLNQNFR 276

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

29-149

8.07e-06

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 46.48 E-value: 8.07e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15307    5 LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFC 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISW 149
Cdd:cd15307   85 TASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVW 125

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

29-154

8.19e-06

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 46.85 E-value: 8.19e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAI----LLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLAdfLVERKTISFEACLAQIFFV 104
Cdd:cd15068    1 SVYITVELAIavlaILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFV 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15068   79 LVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFA 128

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

23-297

8.34e-06

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 46.33 E-value: 8.34e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  23 LQPFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIF 102
Cdd:cd15333    3 LKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 103 FVHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVgfihttsqlAFTVNLP--FCGPNKVDSffcd 180
Cdd:cd15333   83 SDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVI---------SISISLPpfFWRQAKAEE---- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 181 lplVTKLACIDTYVVSLLIVADSGFLSMSSfLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFgpcIFIYVW 260
Cdd:cd15333  150 ---EVSECVVNTDHILYTVYSTVGAFYIPT-LLLIALYGRIYVEARARERKATKTLGIILGAFIVCWLPFF---IISLVL 222

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 282396077 261 PF--SSYSVDKVLAVFYT---IFTPILNPVIYTLRNKEVKAA 297
Cdd:cd15333  223 PIckDACWFHLAIFDFFTwlgYLNSLINPIIYTMSNEDFKQA 264

7tmA_5-HT1A_vertebrates

cd15330

serotonin receptor subtype 1A from vertebrates, member of the class A family of ...

29-297

8.74e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320453 [Multi-domain] Cd Length: 260 Bit Score: 46.51 E-value: 8.74e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15330    5 LFLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGF-IHTTSQLAFTVNLPFCGPNkvdsffcdlplvtkl 187
Cdd:cd15330   85 TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFsISIPPMLGWRTPEDRSDPD--------------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 188 ACIdtyvvsllIVADSGFLSMSSF-------LLLVVSYTVILitvrnRSSASMAKARSTLTAHITVVVLFFGP-CIFIYV 259
Cdd:cd15330  150 ACT--------ISKDPGYTIYSTFgafyiplILMLVLYGRIF-----KAAARERKTVKTLGIIMGTFILCWLPfFIVALV 216

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 282396077 260 WPFSSYSVDKVLAVFYTI-----FTPILNPVIYTLRNKEVKAA 297
Cdd:cd15330  217 LPFCESTCHMPELLGAIInwlgySNSLLNPIIYAYFNKDFQSA 259

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

29-297

9.88e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 46.46 E-value: 9.88e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERK-TISFEACLAQIFFVHLF 107
Cdd:cd15304    5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRwPLPSKLCAVWIYLDVLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 108 TGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWfvgfihttsqlafTVNLPFCGPNKVDSFFCDLPLVTKL 187
Cdd:cd15304   85 STASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVW-------------TISVGISMPIPVFGLQDDSKVFKEG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 188 ACidtyvvsllIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFgpcIFIYVW-PF---- 262
Cdd:cd15304  152 SC---------LLADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQQSISNEQKASKVLGIVFF---LFVVMWcPFfitn 219

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 282396077 263 ----------SSYSVDKVLAVFYTI--FTPILNPVIYTLRNKEVKAA 297
Cdd:cd15304  220 vmavickescNEVVIGGLLNVFVWIgyLSSAVNPLVYTLFNKTYRSA 266

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

32-154

9.93e-06

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 46.31 E-value: 9.93e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  32 SLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPkmLADFLVERKTISFEACLAQIFFVHLFTGGE 111
Cdd:cd15070    8 ILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHAS 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 282396077 112 MVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15070   86 IMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFL 128

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

30-161

1.07e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 46.35 E-value: 1.07e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFAT-PKMLADFLVERKTISFEACLAQIF-FVHLF 107
Cdd:cd15387    6 VLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVlPQLIWDITFRFYGPDFLCRLVKYLqVVGMF 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 282396077 108 TGGEMVLLvsMAYDRYVAICKPLHYMTIMSRRVCIILvciSWFVGFIHTTSQLA 161
Cdd:cd15387   86 ASTYMLLL--MSIDRCLAICQPLRSLHRRSDRVYVLF---SWLLSLVFSIPQVH 134

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

30-295

1.11e-05

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 46.05 E-value: 1.11e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLV-------ERKTISFEACLAQIF 102
Cdd:cd15353    6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLngndtdaQSFTVNIDNVIDSVI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 103 FVHLFtgGEMVLLVSMAYDRYVAICKPLHYMTIMS-RRVCIILVCISWFVgfihTTSQLAFTVnlpfcgpnkvdsfFCDL 181
Cdd:cd15353   86 CSSLL--ASICSLLSIAVDRYFTIFYALQYHNIMTvRRAGVIITCIWTAC----TVSGVLFII-------------YSDS 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 182 PLVtkLACIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVL----FFGPCIFI 257
Cdd:cd15353  147 SVV--IICLISMFFTMLALMASLYVHMFLLARLHIKRIAVLPGTGPIRQGANMKGAITLTILLGVFVVcwapFFLHLIFY 224

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 282396077 258 YVWPFSSYSVDKV----LAVFYTIFTPILNPVIYTLRNKEVK 295
Cdd:cd15353  225 ISCPRNPYCVCFMshfnMYLILIMCNSVIDPLIYAFRSQELR 266

7tmA_Mel1B

cd15400

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

39-156

1.37e-05

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320522 [Multi-domain] Cd Length: 279 Bit Score: 46.00 E-value: 1.37e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  39 LLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGGEMVLLVSM 118
Cdd:cd15400   15 ILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITGI 94

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 282396077 119 AYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHT 156
Cdd:cd15400   95 AINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAI 132

7tmA_mAChR_M5

cd15300

muscarinic acetylcholine receptor subtype M5, member of the class A family of ...

30-154

3.50e-05

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320427 [Multi-domain] Cd Length: 262 Bit Score: 44.63 E-value: 3.50e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTG 109
Cdd:cd15300    6 VTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASN 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 282396077 110 GEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15300   86 ASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFI 130

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

30-152

3.70e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 44.39 E-value: 3.70e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMcVASFAtpKMLADFLVERKTI-------SFEACLAQI- 101
Cdd:cd15350    6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDM-LGSLY--KTLENILIILADMgylnrrgPFETKLDDIm 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 282396077 102 --FFVHLFTGGEMVLLVsMAYDRYVAICKPLHYMTIMS-RRVCIILVCISWFVG 152
Cdd:cd15350   83 dsLFCLSLLGSIFSILA-IAADRYITIFHALRYHNIMTmRRTLVILAIIWTFCG 135

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

41-300

4.83e-05

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 44.05 E-value: 4.83e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  41 GNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERK-TISFEACLAQIFFVHLFTGGEMVLLVSMA 119
Cdd:cd15306   17 GNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMwPLPLVLCPIWLFLDVLFSTASIMHLCAIS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 120 YDRYVAICKPLHYMTIMSRRVCIILVCISWFVgfihttsQLAFTVNLPFCGPNKVDSFFCDLPLVTKLACIDTYVVslli 199
Cdd:cd15306   97 LDRYIAIKKPIQASQYNSRATAFIKITVVWLI-------SIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFIL---- 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 200 vadsgFLSMSSFL----LLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSYSVDK-VLAVF 274
Cdd:cd15306  166 -----FGSLAAFFtplaIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLCDSCNQtTLQML 240

                        250       260       270
                 ....*....|....*....|....*....|..
gi 282396077 275 YTIFTPI------LNPVIYTLRNKEVKAAMSK 300
Cdd:cd15306  241 MEIFVWIgyvssgVNPLVYTLFNKTFRDAFGR 272

7tmA_V2R

cd15388

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...

29-160

6.62e-05

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320510 [Multi-domain] Cd Length: 295 Bit Score: 43.99 E-value: 6.62e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFF--VHL 106
Cdd:cd15388    5 AVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLqvVGM 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 282396077 107 FTGGEMVllVSMAYDRYVAICKPLhyMTIMSRRV-CIILVCISWFVGFIHTTSQL 160
Cdd:cd15388   85 FASSYMI--VAMTFDRHQAICRPM--VTFQKGRArWNGPVCVAWAISLILSLPQV 135

7tmA_alpha2A_AR

cd15322

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

27-297

7.78e-05

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320445 [Multi-domain] Cd Length: 259 Bit Score: 43.39 E-value: 7.78e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15322    3 LIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHY-MTIMSRRV-CIILVC--ISWFVGF--IHTTSQLAFTVNLPFCGPNKVDSFFCD 180
Cdd:cd15322   83 FCTSSIVHLCAISLDRYWSITQAIEYnLKRTPRRIkCIIFIVwvISAVISFppLITIEKKSGQPEGPICKINDEKWYIIS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 181 lplvtklACIDTYVVSLLIvadsgflsmssfllLVVSYTVILITVRNRSSasmaKARSTLTAHITVVVLFFGPCIFIYVW 260
Cdd:cd15322  163 -------SCIGSFFAPCLI--------------MVLVYIRIYQIAKNREK----RFTFVLAVVIGVFVICWFPFFFTYTL 217

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 282396077 261 -PFSSYSVDKVLAVFYTIF---TPILNPVIYTLRNKEVKAA 297
Cdd:cd15322  218 tAVCDCSVPETLFKFFFWFgycNSSLNPVIYTIFNHDFRRA 258

7tmA_D3_dopamine_R

cd15310

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...

29-297

7.79e-05

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320436 [Multi-domain] Cd Length: 259 Bit Score: 43.42 E-value: 7.79e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLAdFLVERKTISFEACLAQIFFVH--L 106
Cdd:cd15310    5 LSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVY-LEVTGGVWNFSRICCDVFVTLdvM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIM---SRRVCIILVCISWFvgfihttsqLAFTVNLPFC-GPNKVDSffcdlP 182
Cdd:cd15310   84 MCTASILNLCAISIDRYTAVVMPVHYQHGTgqsSCRRVSLMITAVWV---------LAFAVSCPLLfGFNTTGD-----P 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 183 LVTKLACIDTYVVSLLIvadSGFLSMSSFLLLVVSYTVILITVRnrssasmaKARSTLTAHITVVVLFFGPCIFIYVWPF 262
Cdd:cd15310  150 TVCSISNPDFVIYSSVV---SFYLPFGVTLLVYVRIYVVLLREK--------KATQMLAIVLGAFIVCWLPFFLTHILNT 218

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 282396077 263 SSYSVdKVLAVFYTIFT------PILNPVIYTLRNKEVKAA 297
Cdd:cd15310  219 HCQAC-HVPPELYSATTwlgyvnSALNPVIYTTFNIEFRRA 258

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

30-151

8.65e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 43.34 E-value: 8.65e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIF------F 103
Cdd:cd15352    6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMdnvfdsM 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 282396077 104 VHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFV 151
Cdd:cd15352   86 ICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVV 133

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

41-160

9.12e-05

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 43.63 E-value: 9.12e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  41 GNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFAT-PKMLADFlverkTISFEA----CLAQIFFVHLFTGGEMVLL 115
Cdd:cd15386   17 GNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVlPQLIWEI-----TYRFQGpdllCRAVKYLQVLSMFASTYML 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 282396077 116 VSMAYDRYVAICKPLHYMTIMSRRVCiILVCISWFVGFIHTTSQL 160
Cdd:cd15386   92 IMMTVDRYIAVCHPLRTLQQPSRQAY-LMIGATWLLSCILSLPQV 135

7tmA_Beta1_AR

cd15958

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...

29-149

9.86e-05

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320624 [Multi-domain] Cd Length: 298 Bit Score: 43.35 E-value: 9.86e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPkmLADFLVERKTISFEAclaqiFFVHLFT 108
Cdd:cd15958    5 LLMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVP--FGATLVVRGRWLYGS-----FFCELWT 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 282396077 109 GGEMV-------LLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISW 149
Cdd:cd15958   78 SVDVLcvtasieTLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVW 125

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

28-297

1.03e-04

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 43.25 E-value: 1.03e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  28 FLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLF 107
Cdd:cd15063    4 LLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 108 TGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFihttsqlaFTVNLPFCGPNKVDSFFCDLPLVTKL 187
Cdd:cd15063   84 CTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSF--------VICFPPLVGWNDGKDGIMDYSGSSSL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 188 ACidtyvvSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSYSV 267
Cdd:cd15063  156 PC------TCELTNGRGYVIYSALGSFYIPMLVMLFFYFRIYRAARMETKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCE 229

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 282396077 268 DKVLAVFYTIF------TPILNPVIYTLRNKEVKAA 297
Cdd:cd15063  230 DCIPPLLFSVFfwlgycNSALNPCIYALFSRDFRFA 265

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

29-294

1.23e-04

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 43.00 E-value: 1.23e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNF--LIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLvERKTISFEACLAQIF-FVH 105
Cdd:cd14981    5 APPALMFVFGVLGNLlaLIVLARSSKSHKWSVFYRLVAGLAITDLLGILLTSPVVLAVYA-SNFEWDGGQPLCDYFgFMM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTG-GEMVLLVSMAYDRYVAICKPLHYMTIMS-RRVCIILVCISWFVGFIHTtsqlaftvnLPFCGPNKVDSFF----C 179
Cdd:cd14981   84 SFFGlSSLLIVCAMAVERFLAITHPFFYNSHVKkRRARLMLGAVWAFALLIAS---------LPLLGLGSYVLQYpgtwC 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 180 dlplvtklaCIDTYVVSLLIVADSGFLSMSSFLLLVVSY----TVILITVRN-----RSSASMAKARSTLTAHITVVVLF 250
Cdd:cd14981  155 ---------FLDFYSKNTGDAAYAYLYSILGLLILLVTLlcnlLVIITLLRMrrrkkRHRRSRRSARRQKRNEIQMVVLL 225

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 282396077 251 FG------PC-----IFIYVWPFSSYSVDKV---LAVFYTIFTPILNPVIYTLRNKEV 294
Cdd:cd14981  226 LAitvvfsVCwlplmIRVLINATGDSEKNGKtdlLAVRMASWNQILDPWVYILLRKEV 283

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

28-149

1.36e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 43.01 E-value: 1.36e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  28 FLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERK-TISFEACLAQIFFVHL 106
Cdd:cd15217    4 LVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAwTYSVLSCKIVAFMAVL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISW 149
Cdd:cd15217   84 FCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVW 126

7tmA_Histamine_H4R

cd15295

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...

27-167

1.39e-04

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320422 [Multi-domain] Cd Length: 267 Bit Score: 42.89 E-value: 1.39e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15295    3 LLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYL 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRrvciilvcISWFVGFIHTTSQLAFTVNLP 167
Cdd:cd15295   83 LCTASVYNIVLISYDRYQSVSNAVSYRNQQTA--------TLRIVTQMVAVWVLAFLVHGP 135

7tmA_D2-like_dopamine_R

cd15053

D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...

29-165

1.49e-04

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320181 [Multi-domain] Cd Length: 263 Bit Score: 42.72 E-value: 1.49e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATP---------------KMLADFLVerkTIS 93
Cdd:cd15053    5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPfavyvevnggkwylgPILCDIYI---AMD 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 282396077  94 FEACLAQIFfvhlftggemvLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIhTTSQLAFTVN 165
Cdd:cd15053   82 VMCSTASIF-----------NLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAA-IACPLLFGLN 141

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

30-297

1.56e-04

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 42.62 E-value: 1.56e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTG 109
Cdd:cd15323    6 VVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 110 GEMVLLVSMAYDRYVAICKPLHY-MTIMSRRVCIILVCIsWFVGFIhttsqlaftVNLPfcgpnkvdsffcdlPLVTKLA 188
Cdd:cd15323   86 SSIVHLCAISLDRYWSVTQAVEYnLKRTPRRVKAIIVTV-WLISAV---------ISFP--------------PLISMYR 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 189 CIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSaSMAKARST-LTAHITVVVLFFGPCIFIYVWPFSSYSV 267
Cdd:cd15323  142 DPEGDVYPQCKLNDETWYILSSCIGSFFAPCLIMILVYIRIY-RVAKAREKrFTFVLAVVMGVFVVCWFPFFFSYSLYGI 220

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 282396077 268 --------DKVLAVFYTI--FTPILNPVIYTLRNKEVKAA 297
Cdd:cd15323  221 creacevpEPLFKFFFWIgyCNSSLNPVIYTIFNQDFRRS 260

7tmA_5-HT5

cd15328

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...

30-162

1.57e-04

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320451 [Multi-domain] Cd Length: 259 Bit Score: 42.63 E-value: 1.57e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERK-TISFEACLAQIFFVHLFT 108
Cdd:cd15328    6 LLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRwQLGRSLCQVWISFDVLCC 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAF 162
Cdd:cd15328   86 TASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLF 139

7tmA_capaR

cd15134

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...

29-251

1.68e-04

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.

Pssm-ID: 320262 [Multi-domain] Cd Length: 298 Bit Score: 42.70 E-value: 1.68e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEA-CLAQIFFVHLF 107
Cdd:cd15134    5 IIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPWVFGEVfCKLRAFLSEMS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 108 TGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIhttsqlaftVNLPFCGpnKVDSFFCDLPLVTKL 187
Cdd:cd15134   85 SYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFV---------CALPFAI--QTRIVYLEYPPTSGE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 188 ACIDTYVVSLL--IVADSGFLSMSSFL-------LLVVSYTVILITVRNRSSASMAKARSTLTAH------------ITV 246
Cdd:cd15134  154 ALEESAFCAMLneIPPITPVFQLSTFLffiipmiAIIVLYVLIGLQLRRSTLLRRGQRSVSGGRRssqsrrtvlrmlVAV 233


                 ....*
gi 282396077 247 VVLFF 251
Cdd:cd15134  234 VVAFF 238

7tmA_Mel1A

cd15402

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

28-154

1.72e-04

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320524 [Multi-domain] Cd Length: 279 Bit Score: 42.58 E-value: 1.72e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  28 FLIFSLLylAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLF 107
Cdd:cd15402    6 ILIFTIV--VDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLS 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 282396077 108 TGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15402   84 VIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVA 130

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

26-154

1.92e-04

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 42.24 E-value: 1.92e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15299    5 LIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDY 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15299   85 VASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFV 133

7tmA_MWS_opsin

cd15080

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...

34-298

1.95e-04

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 381742 [Multi-domain] Cd Length: 280 Bit Score: 42.51 E-value: 1.95e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  34 LYLAILLG---NFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLftGG 110
Cdd:cd15080    7 MFLLILLGfpiNFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATL--GG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 111 EMVL--LVSMAYDRYVAICKPLHYMTIMSRRVcIILVCISWFVGFIHTTSQLA-FTVNLP-----FCGPNkvdsFFCDLP 182
Cdd:cd15080   85 EIALwsLVVLAIERYVVVCKPMSNFRFGENHA-IMGVAFTWVMALACAAPPLVgWSRYIPegmqcSCGID----YYTLKP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 183 LVTKlaciDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFGPC-------- 254
Cdd:cd15080  160 EVNN----ESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICwvpyasva 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 282396077 255 IFIYVWPFSSYS-VDKVLAVFYTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15080  236 FYIFTHQGSDFGpIFMTIPAFFAKSSAVYNPVIYILMNKQFRNCM 280

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

27-154

2.23e-04

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 42.19 E-value: 2.23e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15325    3 LGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15325   83 CCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLV 130

7tmA_5-HT4

cd15056

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...

27-151

2.74e-04

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320184 [Multi-domain] Cd Length: 294 Bit Score: 42.09 E-value: 2.74e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15056    3 LSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 282396077 107 FTGGEMVLLVSMAYDRYVAIC-KPLHYMtiMSRRVCIILVCISWFV 151
Cdd:cd15056   83 LTTASIMHLCCIALDRYYAICcQPLVYK--MTPLRVAVMLGGCWVI 126

7tmA_alpha1D_AR

cd15327

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

29-297

2.76e-04

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320450 [Multi-domain] Cd Length: 261 Bit Score: 41.82 E-value: 2.76e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPkmladFLVERKTISFEA-----CLAQIFF 103
Cdd:cd15327    5 VFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLP-----FSATLEVLGFWAfgrvfCDIWAAV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 104 VHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLaftvnLPFCGPNKVDSFFCDlpl 183
Cdd:cd15327   80 DVLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPL-----LGWKEPPPPDESICS--- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 184 vtklacidtyvvsllIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASM-----AKARSTLTAHITVVVLFFGPciFIY 258
Cdd:cd15327  152 ---------------ITEEPGYALFSSLFSFYLPLMVILVMYFRVYVVALkfsreKKAAKTLAIVVGVFILCWFP--FFF 214

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 282396077 259 VWPFSSY-----SVDKVLAVFYTI--FTPILNPVIYTLRNKEVKAA 297
Cdd:cd15327  215 VLPLGSFfpalkPSEMVFKVIFWLgyFNSCVNPIIYPCSSKEFKRA 260

7tmA_tmt_opsin

cd15086

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...

39-293

2.86e-04

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.

Pssm-ID: 320214 [Multi-domain] Cd Length: 276 Bit Score: 42.03 E-value: 2.86e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  39 LLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGGEMVLLVSM 118
Cdd:cd15086   15 FLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIVSLISLAVL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 119 AYDRYVAICKPLHYMTIMSRRVCIIlVCISWFVGFIHTTSQLAFTVNLPFCGPNKVdsffCDLPLVTKLACIDTYVVSLL 198
Cdd:cd15086   95 SYERYCTLLRPTEADVSDYRKAWLG-VGGSWLYSLLWTLPPLLGWSSYGPEGPGTT----CSVQWTSRSANSISYIICLF 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 199 IvadsgFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTlTAHITVVVLFFGPCIFIYVWPfssYSVDKVLAVF--YT 276
Cdd:cd15086  170 I-----FCLLLPFLVMVYCYGRLLYAIKQVGKINKSTARKR-EQHVLLMVVTMVICYLLCWLP---YGVMALLATFgkPG 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 282396077 277 IFTP--------------ILNPVIYTLRNKE 293
Cdd:cd15086  241 LVTPvasivpsilaksstVVNPIIYVFMNKQ 271

7tmA_SWS2_opsin

cd15077

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...

32-298

2.90e-04

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320205 [Multi-domain] Cd Length: 280 Bit Score: 41.74 E-value: 2.90e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  32 SLLYLAILLG---NFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLft 108
Cdd:cd15077    5 AFMLFLVIAGfpiNVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATL-- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 109 gGEMVLLVSMA---YDRYVAICKPLHYMTImsRRVCIILVCI-SWFVGFIHTTSQL-AFTVNLP-----FCGPnkvdsff 178
Cdd:cd15077   83 -GGMVSLWSLAvvaFERFLVICKPLGNFTF--RGTHAIIGCIaTWVFGLAASLPPLfGWSRYIPeglqcSCGP------- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 179 cDLPLVTKLACIDTYVVSLLIvadsgFLSMSSFLLLVVSYTVILITVR-----NRSSASMAKARSTLTAHITVVVLFFGP 253
Cdd:cd15077  153 -DWYTTNNKWNNESYVMFLFC-----FCFGVPLSIIVFSYGRLLLTLRavakqQEQSASTQKAEREVTKMVVVMVLGFLV 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 282396077 254 CIFIY----VWPFSSY--SVDKVLAVFYTIF---TPILNPVIYTLRNKEVKAAM 298
Cdd:cd15077  227 CWLPYasfaLWVVTNRgePFDLRLASIPSVFskaSTVYNPVIYVFMNKQFRSCM 280

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

39-298

2.96e-04

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 41.65 E-value: 2.96e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  39 LLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGGEMVLLVSM 118
Cdd:cd15073   15 TISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 119 AYDRYVAICKPLHYMTiMSRRVCIILVCISWFVGFihttsqlaFTVNLPFCGpnkvdsFFCDLPLVTKLACIDTYVVSll 198
Cdd:cd15073   95 AVDRYLTICRPDLGRK-MTTNTYTVMILLAWTNAF--------FWAAMPLVG------WASYALDPTGATCTINWRKN-- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 199 ivaDSGFLS--MSSFLL-LVVSYTVILITVRNRSSASMAKARSTLTAHITV---------------VVLFF---GPCIFI 257
Cdd:cd15073  158 ---DSSFVSytMSVIVVnFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIdwtdqndvtkmsvimIVMFLvawSPYSIV 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 282396077 258 YVWpfSSYSVDKVLAVFYTIFTPIL-------NPVIYTLRNKEVKAAM 298
Cdd:cd15073  235 CLW--ASFGEPKKIPPWMAIIPPLFaksstfyNPCIYVIANKKFRRAI 280

7tmA_S1PR

cd15102

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...

30-298

3.03e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320230 [Multi-domain] Cd Length: 270 Bit Score: 41.69 E-value: 3.03e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMcvasFATPKMLADFLVERKTiSFEACLAQIF------F 103
Cdd:cd15102    6 VFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDL----LAGAAYLANILLSGAR-TLRLSPAQWFlregsmF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 104 VHLftGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVcIILVCISWFVGFIHTTsqlaftvnLPFCGPN---KVDSFFCD 180
Cdd:cd15102   81 VAL--SASVFSLLAIAIERHLTMAKMKPYGASKTSRV-LLLIGACWLISLLLGG--------LPILGWNclgALDACSTV 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 181 LPLVTK---LACIDTYVVSLLIVadsgflsmssflllVVSYTVILITVRNRSSASMAKARS----TLTAHITVVVLFFGP 253
Cdd:cd15102  150 LPLYSKhyvLFCVTIFAGILAAI--------------VALYARIYCLVRASGRKATRASASprslALLKTVLIVLLVFIA 215

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 282396077 254 C-----------IFIYVWPFSS-YSVDKVLAVfyTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15102  216 CwgplfilllldVACPVKTCPIlYKADWFLAL--AVLNSALNPIIYTLRSRELRRAV 270

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

25-298

3.12e-04

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 41.87 E-value: 3.12e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  25 PFLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd14982    1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTvnLPFCGPNKVDSFFCDLPLV 184
Cdd:cd14982   81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLR--STIAKENNSTTCFEFLSEW 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIdtYVVSLLIVadsGFLsmSSFLLLVVSYTVILITVRNRSSAS-----MAKARSTLTAHITVVVLFFGP---CIF 256
Cdd:cd14982  159 LASAAP--IVLIALVV---GFL--IPLLIILVCYSLIIRALRRRSKQSqksvrKRKALRMILIVLAVFLVCFLPyhvTRI 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 282396077 257 IYVW----PFSSYSVDKVLAVFYTI------FTPILNPVIYTLRNKEVKAAM 298
Cdd:cd14982  232 LYLLvrlsFIADCSARNSLYKAYRItlclasLNSCLDPLIYYFLSKTFRKRL 283

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

29-297

3.38e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 41.42 E-value: 3.38e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15326    5 LVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCC 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLaftvnLPFCGPNKVDSFFCDL---PLVT 185
Cdd:cd15326   85 TASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPL-----LGWKEPAPPDDKVCEIteePFYA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLACIDTYVVSLLIVadsgflsmssFLLLVVSYTVILITVRNRssasmaKARSTLTAHITVVVLFFGPciFIYVWPFSSY 265
Cdd:cd15326  160 LFSSLGSFYIPLIVI----------LVMYCRVYIVALKFSREK------KAAKTLGIVVGMFILCWLP--FFIALPLGSL 221

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 282396077 266 SV-----DKVLAVFYTI--FTPILNPVIYTLRNKEVKAA 297
Cdd:cd15326  222 FShlkppETLFKIIFWLgyFNSCLNPIIYPCSSKEFKRA 260

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

26-297

3.72e-04

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 41.56 E-value: 3.72e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15059    2 AISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGF-------IHTTSQLAFTVNLPFCGPNkvdsff 178
Cdd:cd15059   82 LFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAvislpplFGWKDEQPWHGAEPQCELS------ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 179 cDLPLVTKLACIDTYVVSLLIvadsgflsmssfllLVVSYTVILITVRNRssasmaKARSTLTahITVVVLFFGPCIFIY 258
Cdd:cd15059  156 -DDPGYVLFSSIGSFYIPLLI--------------MIIVYARIYRAAKRK------ERRFTLV--LGVVMGAFVLCWLPF 212

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 282396077 259 vwpFSSYSV----------DKVLAVFYTI--FTPILNPVIYTLRNKEVKAA 297
Cdd:cd15059  213 ---FFTYPLvvvcktcgvpELLFKFFFWLgyCNSALNPVIYTIFNKDFRRA 260

7tmA_D1-like_dopamine_R

cd15057

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...

29-149

3.87e-04

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320185 [Multi-domain] Cd Length: 299 Bit Score: 41.65 E-value: 3.87e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMY-FLLANLSFIDMCVASFATPkMLADFLVERKTISFEACLAQIFFVHLF 107
Cdd:cd15057    5 CILYLLVLLTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLVAILVMP-WAAVNEVAGYWPFGSFCDVWVSFDIMC 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 282396077 108 TGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISW 149
Cdd:cd15057   84 STASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAW 125

7tmA_Relaxin_R

cd15137

relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...

114-295

3.95e-04

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.

Pssm-ID: 320265 [Multi-domain] Cd Length: 284 Bit Score: 41.42 E-value: 3.95e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 114 LLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCIsWFVGFIhttsqLAFtvnLPFCGPNKVDSFF-----CdLPLvtkla 188
Cdd:cd15137   97 ILTLITLDRFICIVFPFSGRRLGLRRAIIVLACI-WLIGLL-----LAV---LPLLPWDYFGNFYgrsgvC-LPL----- 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 189 CIDT-------YVVSLLIvadsgFLSMSSFLLLVVSYTVILITVRNRSSAS---MAKARSTLTAHITVVVL--FFG--PC 254
Cdd:cd15137  162 HITDerpagweYSVFVFL-----GLNFLAFVFILLSYIAMFISIRRTRKAAasrKSKRDMAVAKRFFLIVLtdFLCwiPI 236

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 282396077 255 IFIYVWPFSSYSVDKVLAVFYTIFT-PI---LNPVIYTLRNKEVK 295
Cdd:cd15137  237 IVIGILALSGVPIPGEVYAWVAVFVlPInsaLNPILYTLSTPKFR 281

7tmA_Parapinopsin

cd15075

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...

27-295

3.96e-04

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.

Pssm-ID: 320203 [Multi-domain] Cd Length: 279 Bit Score: 41.30 E-value: 3.96e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15075    3 LSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAVAF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTiMSRRVCIILVCISWFVGFIHTTSQL------AFTVNLPFCGPNKVDSffcD 180
Cdd:cd15075   83 FGIAALCTVAVIAVDRLFVVCKPLGTLT-FQTRHALAGIASSWLWSLIWNTPPLfgwgsyQLEGVMTSCAPDWYSR---D 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 181 LPLVTKLACIDTYVVSLlivadsgflsmsSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHIT----VVVLFFgpcIF 256
Cdd:cd15075  159 PVNVSYILCYFSFCFAI------------PFAIILVSYGYLLWTLRQVAKLGVAEGGSTAKAEVQvarmVVVMVM---AF 223

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 282396077 257 IYVW-PFSSYS-------------VDKVLAVFYTIFTPILNPVIYTLRNKEVK 295
Cdd:cd15075  224 LLCWlPYAAFAltvvskpdvyinpLIATVPMYLAKSSTVYNPIIYIFMNKQFR 276

7tmA_LPAR1_Edg2

cd15344

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...

38-296

4.69e-04

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 341348 [Multi-domain] Cd Length: 273 Bit Score: 41.16 E-value: 4.69e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  38 ILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMcVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGGEMVLLVS 117
Cdd:cd15344   14 IMLANLLVMVAIYVNRRFHFPIYYLMANLAAADF-FAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 118 MAYDRYVAICKpLHYMTIMSRRVCIILVCISWFVGFIHTTsqlaftvnLPFCGPNKVdsffCDLPLVTKLACI--DTYVV 195
Cdd:cd15344   93 IAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGA--------IPSVGWNCI----CDIENCSNMAPLysDSYLV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 196 SLLIvadsgfLSMSSFLLLVVSYTVILITVRNRS------SASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSYSVDK 269
Cdd:cd15344  160 FWAI------FNLVTFVVMVVLYAHIFGYVRQRTmrmsrhSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDV 233

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 282396077 270 VLA-----------VFYTIFTPILNPVIYTLRNKEVKA 296
Cdd:cd15344  234 CCPqcdvlayekffLLLAEFNSAMNPIIYSYRDKEMSA 271

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

30-287

5.04e-04

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 41.13 E-value: 5.04e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASfATPKMLADFLVERKTISFEACLAQIFFVHL--F 107
Cdd:cd14970    6 VYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLL-GLPFLATSYLLGYWPFGEVMCKIVLSVDAYnmF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 108 TGgeMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFcgPNKVDSFFCDLP----L 183
Cdd:cd14970   85 TS--IFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQE--EGGTISCNLQWPdppdY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 184 VTKLACIDTYVVSLLIvadsgflsmsSFLLLVVSYTVILITVR------NRSSASMAKARSTLTAHITVVVLFFGPC--- 254
Cdd:cd14970  161 WGRVFTIYTFVLGFAV----------PLLVITVCYSLIIRRLRssrnlsTSGAREKRRARRKVTRLVLVVVAVFVVCwlp 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 282396077 255 --IFIYVWPFSSYSVDKVLAVFYTIFTPI------LNPVIY 287
Cdd:cd14970  231 fhVFQIVRLLIDPPETLTVVGVFLFCIALsyanscLNPILY 271

7tmA_Histamine_H3R

cd15296

histamine receptor subtypes H3R and H3R-like, member of the class A family of ...

26-154

5.05e-04

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320423 [Multi-domain] Cd Length: 271 Bit Score: 40.93 E-value: 5.05e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15296    2 ILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDY 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTI--MSRRVCIILVCIsWFVGFI 154
Cdd:cd15296   82 LLCTASVFNIVLISYDRFLSVTRAVSYRAQkgMTRQAVLKMVLV-WVLAFL 131

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

30-151

5.28e-04

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 41.05 E-value: 5.28e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTG 109
Cdd:cd15959    6 LLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVT 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 282396077 110 GEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFV 151
Cdd:cd15959   86 ASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAI 127

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

27-162

5.57e-04

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 41.30 E-value: 5.57e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFlIILTVTSDSRLHTPMYFLLANLSFIDMC-VASFatPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:PHA03087  43 LIVVYSTIFFFGLVGNI-IVIYVLTKTKIKTPMDIYLLNLAVSDLLfVMTL--PFQIYYYILFQWSFGEFACKIVSGLYY 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAF 162
Cdd:PHA03087 120 IGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFV 176

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

39-292

5.58e-04

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 41.11 E-value: 5.58e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  39 LLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGGEMVLLVSM 118
Cdd:cd15074   15 TLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLTAI 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 119 AYDRYVAICKPlHYMTIMSRRVCIILVCISWFVGFIHTTSqlaftvnlPFCGPNKvdsfFCDLPLVTKlACIDTYVVSLL 198
Cdd:cd15074   95 SIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAVA--------PLVGWGS----YGPEPFGTS-CSIDWTGASAS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 199 IVADSGFLSMSSF------LLLVVSYTVILITVRNRSSA-----SMAKARSTLTAHITVVVLFFgpCI-FIYVW-PF--- 262
Cdd:cd15074  161 VGGMSYIISIFIFcyllpvLIIVFSYVKIIRKVKSSRKRvagfdSRSKRQHKIERKVTKVAVLI--CAgFLIAWtPYavv 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 282396077 263 -------SSYSVDKVLAVFYTIF---TPILNPVIYTLRNK 292
Cdd:cd15074  239 smwsafgSPDSVPILASILPALFaksSCMYNPIIYLLFSS 278

7tmA_D2_dopamine_R

cd15309

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...

29-297

6.03e-04

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320435 [Multi-domain] Cd Length: 254 Bit Score: 40.79 E-value: 6.03e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15309    5 MLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMC 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMT-IMSRRVCIILVCISWFvgfihttsqLAFTVNLPFC-GPNKVDSFFCdlplvtk 186
Cdd:cd15309   85 TASILNLCAISIDRYTAVAMPMLYNTrYSSKRRVTVMISVVWV---------LSFAISCPLLfGLNNTDQNEC------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 lacidtyvvsllIVADSGFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPFSSYS 266
Cdd:cd15309  149 ------------IIANPAFVVYSSIVSFYVPFIVTLLVYVQIYIVLQKEKKATQMLAIVLGVFIICWLPFFITHILNMHC 216

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 282396077 267 VDKVLAVFYTIFTPI------LNPVIYTLRNKEVKAA 297
Cdd:cd15309  217 DCNIPPALYSAFTWLgyvnsaVNPIIYTTFNIEFRKA 253

7tmA_GPR19

cd15008

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...

29-149

6.06e-04

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320137 [Multi-domain] Cd Length: 275 Bit Score: 40.97 E-value: 6.06e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15008    4 LVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTP 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMtiMSRRVCIILVCISW 149
Cdd:cd15008   84 GVQIYVLLSICVDRFYTIVYPLSFK--VSREKAKKMIAASW 122

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

30-159

7.13e-04

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 40.57 E-value: 7.13e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFAT-PKMLADFLVERKTISFeacLAQIFfVHLFT 108
Cdd:cd15385    6 VLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVlPQLCWDITYRFYGPDF---LCRIV-KHLQV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 282396077 109 GGEMV---LLVSMAYDRYVAICKPLHYMTIMSRRvCIILVCISWFVGFIHTTSQ 159
Cdd:cd15385   82 LGMFAstyMLVMMTADRYIAICHPLKTLQQPTKR-SYLMIGSAWALSFILSTPQ 134

7tmA_GPBAR1

cd15905

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...

27-149

7.20e-04

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.

Pssm-ID: 320571 [Multi-domain] Cd Length: 272 Bit Score: 40.51 E-value: 7.20e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMC--VASFATPKMLADflverKTISFEACLAQIFFV 104
Cdd:cd15905    1 IFWLSVPLSSLIIFANLFIILGIACNRKLHNTANYFFLSLLLADLLtgVALPFIPGMSNE-----SRRGYHSCLFVYVAP 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISW 149
Cdd:cd15905   76 NFLFLSFLANLLMVHYERYLCIVYPLQYHNFWVHRWVPLALLLTW 120

7tmA_GPR83

cd15389

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...

27-250

9.79e-04

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.

Pssm-ID: 320511 [Multi-domain] Cd Length: 285 Bit Score: 40.40 E-value: 9.79e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEAC----LAQIF 102
Cdd:cd15389    3 LIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMChlsrFAQYC 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 103 FVHLFTggemVLLVSMAYDRYVAICKPLHYMtiMSRRVCIILVCISWFvgfihttsqLAFTVNLPFCGPNKVDSFFCDLp 182
Cdd:cd15389   83 SVYVST----LTLTAIALDRHRVILHPLKPR--ITPCQGVVVIAIIWI---------MASCLSLPHAIYQKLVEFEYSN- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 183 LVTKLACIDTY------VVSLLIVADSGFLSMSSFLLLVVSYTVILITVRNRSS----------ASMAKARSTLTAHITV 246
Cdd:cd15389  147 ERTRSRCLPSFpepsdlFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLWLRNAigdvtteqyvAQRRKKKKTIKMLMLV 226


                 ....
gi 282396077 247 VVLF 250
Cdd:cd15389  227 VLLF 230

7tmA_GPR26_GPR78-like

cd15219

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...

39-163

9.94e-04

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320347 [Multi-domain] Cd Length: 264 Bit Score: 40.13 E-value: 9.94e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  39 LLGNFLIILTV--TSDSRLHTPMYFLLaNLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGGEMVLLV 116
Cdd:cd15219   14 LLSNLLVLLCFlySAELRKQVPGIFLL-NLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAMLSMA 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 282396077 117 SMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFT 163
Cdd:cd15219   93 ALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFLS 139

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

40-242

1.09e-03

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 40.00 E-value: 1.09e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  40 LGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTI-SFEACLAQIFFVHLFTGGEMVLLVSM 118
Cdd:cd15337   16 IGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGFPLKTISSFNKKWIwGKVACELYGFAGGIFGFMSITTLAAI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 119 AYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTsqlaftvnLPFCGPNK-VDSFF---CDLPLVTKLACIDTYV 194
Cdd:cd15337   96 SIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSI--------PPFFGWGRyVPEGFqtsCTFDYLSRDLNNRLFI 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 282396077 195 VSLLIVadsGFlsMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTA 242
Cdd:cd15337  168 LGLFIF---GF--LCPLLIIIFCYVNIIRAVRNHEKEMTQTAKSGMGK 210

7tmA_TAAR6_8_9

cd15316

trace amine-associated receptors 6, 8, and 9, member of the class A family of ...

27-158

1.12e-03

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320439 [Multi-domain] Cd Length: 290 Bit Score: 40.23 E-value: 1.12e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFID----MCVASFATPKMLAD-FLVERKTISFEACLAQI 101
Cdd:cd15316    3 LYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADflvgVTVMPFSTVRSVEScWYFGESFCTFHTCCDVS 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 282396077 102 F-FVHLFTggemvlLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTS 158
Cdd:cd15316   83 FcYASLFH------LCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFS 134

7tmA_mAChR_M2

cd15297

muscarinic acetylcholine receptor subtype M2, member of the class A family of ...

26-154

1.22e-03

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320424 [Multi-domain] Cd Length: 262 Bit Score: 39.95 E-value: 1.22e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15297    2 FIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15297   82 VVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFI 130

7tmA_Parietopsin

cd15085

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...

28-295

1.33e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320213 [Multi-domain] Cd Length: 280 Bit Score: 39.84 E-value: 1.33e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  28 FLIFSLLYLAILlGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLF 107
Cdd:cd15085    5 FLMFLNATFSIF-NNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 108 TGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNlpfcGPNKVDSfFCDLPLVTKL 187
Cdd:cd15085   84 GIVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSY----GPEGVQT-SCSIGWEERS 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 188 ACIDTYVVSLLIVAdsgflSMSSFLLLVVSYTVILITVR--NRSSASM-AKARSTLTAHITVVVLFFGPCIFIYVWPFSS 264
Cdd:cd15085  159 WSNYSYLILYFLMC-----FVIPVAIIGFSYGNVLRSLHklNKKIEQQgGKNCPEEEERAVIMVLAMVIAFLICWLPYTV 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 282396077 265 YSVDKV-------------LAVFYTIFTPILNPVIYTLRNKEVK 295
Cdd:cd15085  234 FALIVVvnpelsisplaatMPTYFAKTSPVYNPIIYIFLNKQFR 277

7tmA_NPY5R

cd15398

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...

26-153

1.67e-03

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.

Pssm-ID: 320520 [Multi-domain] Cd Length: 273 Bit Score: 39.37 E-value: 1.67e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVH 105
Cdd:cd15398    2 FLIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQC 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHymTIMSRRVCIILVCISWFVGF 153
Cdd:cd15398   82 VSVMVSTLMLMSIAIVRYHMIKHPLS--NHLTANHGYFLLGTVWTLGF 127

7tmA_GPR151

cd15002

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...

30-163

1.81e-03

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320133 [Multi-domain] Cd Length: 280 Bit Score: 39.32 E-value: 1.81e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTP--MYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLF 107
Cdd:cd15002    5 LLGVICLLGFAGNLMVIGILLNNARKGKPslIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHAC 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 282396077 108 TGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCIsWFVGFIHTTSQLAFT 163
Cdd:cd15002   85 MAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVVASI-WVPACLLPLPQWLFR 139

7tmA_Glycoprotein_LRR_R-like

cd14980

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...

39-295

2.34e-03

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.

Pssm-ID: 320111 [Multi-domain] Cd Length: 286 Bit Score: 39.15 E-value: 2.34e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  39 LLGNFLIILTVTSDSRL-HTPMYFLLANLSFIDMCVASFATPKMLAD-FLVERKTISFE------ACLAQIFFVHLFTGG 110
Cdd:cd14980   15 LIGNILVIIWHISSKKKkKKVPKLLIINLAIADFLMGIYLLIIAIADqYYRGRYAQYSEewlrspPCLLACFLVSLSSLM 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 111 EMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVcISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCdLPLVTKLACI 190
Cdd:cd14980   95 SVLMMLLITLDRYICIVYPFSNKRLSYKSAKIILI-LGWLFSIIFAAIPILYSINQPGDNRLYGYSSIC-MPSNVSNPYY 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 191 DTYVVSLLivadsgFLSMSSFLLLVVSYTVILITV--------RNRSSASMAKARSTLTAHITVVVLFFGPCIFIYVWPF 262
Cdd:cd14980  173 RGWLIAYL------LLTFIAWIIICILYILIFISVrksrksarRSSSKRDKRIAIRLALILITDLICWLPYYIVIFSGLL 246

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 282396077 263 SSYSVDKVLAVFYTIFT-PI---LNPVIYTLRNKEVK 295
Cdd:cd14980  247 TSTEIDIHVLQFIAILAlPLnsaINPYLYTLTTPTFK 283

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

29-297

2.37e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 39.01 E-value: 2.37e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15062    5 VALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCC 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLaftvnLPFCGPNKVDSFFCDlplVTKLA 188
Cdd:cd15062   85 TASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPL-----LGWKEPAPADEQACG---VNEEP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 189 cidTYVVsllivadsgFLSMSSFLL----LVVSYTVILITVRNRSSASmaKARSTLTAHITVVVLFFGPciFIYVWPFSS 264
Cdd:cd15062  157 ---GYVL---------FSSLGSFYLplaiILVMYCRVYVVAFKFSREK--KAAKTLGIVVGAFVLCWFP--FFVVLPLGS 220

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 282396077 265 Y--SVDKVLAVFYTIF-----TPILNPVIYTLRNKEVKAA 297
Cdd:cd15062  221 LfsTLKPPEPVFKVVFwlgyfNSCLNPIIYPCSSREFKRA 260

7tmA_GPR101

cd15215

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...

29-160

2.44e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320343 [Multi-domain] Cd Length: 261 Bit Score: 39.06 E-value: 2.44e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAiLLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15215    5 LIVIFLCAS-LFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFA 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQL 160
Cdd:cd15215   84 FAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPL 135

7tmA_Cannabinoid_R

cd15099

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...

33-298

2.58e-03

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320227 [Multi-domain] Cd Length: 281 Bit Score: 39.05 E-value: 2.58e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  33 LLYLAILLGNFLIILTVTSDSRLH-TPMYFLLANLSFIDMCVASFATPKMLaDFLVERKTISFEACLAQIFFVHLFTGGE 111
Cdd:cd15099    9 LAGPVTFLENILVLLTILSSTALRrRPSYLFIGSLALADMLASVIFTISFL-DFHVFHQRDSRNLFLFKLGGVTMAFTAS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 112 MVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIhttsqLAFtvnLPFCGPN--KVDSFFCDL-PLVTKla 188
Cdd:cd15099   88 VGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTII-----ISF---LPLMGWRckTWDSPCSRLfPYIDR-- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 189 cidTYVVSLLivadsGFLSMsSFLLLVVSYTVILITVrNRSSASMAKARS-------------------TLTAHITVVVL 249
Cdd:cd15099  158 ---HYLASWT-----GLQLV-LLFLIIYAYPYILWKA-HRHEANMGGPKLgrqqvkgqarmrmdirlakTLSLILLVLAI 227

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 282396077 250 FFGPCIFIYVWPFSSYSVDKVLAVF-----YTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15099  228 CWLPVLAFMLVDVRVTLTNKQKRMFafcsmLCLVNSCVNPIIYALRSRELRGAM 281

7tmA_QRFPR

cd15205

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...

27-154

2.59e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.

Pssm-ID: 320333 [Multi-domain] Cd Length: 298 Bit Score: 38.99 E-value: 2.59e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATP-KMLADFLVERKTISFeACLAQIFFVH 105
Cdd:cd15205    3 FVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPfTLLQNISSNWLGGAF-MCKMVPFVQS 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 282396077 106 LFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15205   82 TAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVI 130

7tmA_KiSS1R

cd15095

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...

29-289

2.91e-03

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.

Pssm-ID: 320223 [Multi-domain] Cd Length: 288 Bit Score: 38.80 E-value: 2.91e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANL-----SFIDMCV----ASFATPK-MLADFLverktisfeaCL 98
Cdd:cd15095    5 LIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLavtdlAFLVCCVpftaALYATPSwVFGDFM----------CK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  99 AQIFFVHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGF--------IHTTSQLAFTVNLPFCG 170
Cdd:cd15095   75 FVNYMMQVTVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFllsipvaiYYRLEEGYWYGPQTYCR 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 171 ---PNKVDSFFCDLPLVtklacIDTYVVSLLIVAdsgflsmssflllvVSYTVILITVRNRSSASMA------------K 235
Cdd:cd15095  155 evwPSKAFQKAYMIYTV-----LLTYVIPLAIIA--------------VCYGLILRRLWRRSVDGNNqseqlseralrqK 215

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 282396077 236 ARSTLTAhITVVVLF---FGPCIFIYVWPFSSYSVDKVLAVFY--------TIFTPILNPVIYTL 289
Cdd:cd15095  216 RKVTRMV-IVVVVLFaicWLPNHVLNLWQRFDPNFPETYATYAlkiaalclSYANSAVNPFVYAF 279

7tmA_Glyco_hormone_R

cd15136

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...

33-295

3.12e-03

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.

Pssm-ID: 320264 [Multi-domain] Cd Length: 275 Bit Score: 38.74 E-value: 3.12e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  33 LLYLAILLGNfLIILTVTSDSRLHTPM-YFLLANLSFIDMCVA------SFATPKMLADFLVERKTISFEA-CLAQIFFV 104
Cdd:cd15136    9 FVFLLALVGN-IIVLLVLLTSRTKLTVpRFLMCNLAFADFCMGiylgllAIVDAKTLGEYYNYAIDWQTGAgCKTAGFLA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIhttsqLAFtvnLPFCGPNKVDSFFCDLPLV 184
Cdd:cd15136   88 VFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALI-----MAL---LPLVGVSSYSKTSICLPFE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 185 TKLACIDTYVVSLLIvadsgfLSMSSFLLLVVSYTVILITVRNRSSAS------MAKARSTLtahITVVVLFFGPCIF-- 256
Cdd:cd15136  160 TETPVSKAYVIFLLL------FNGLAFLIICGCYIKIYLSVRGSGRAAnsndtrIAKRMALL---VFTDFLCWAPIAFfg 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 282396077 257 ---IYVWPFSSYSVDKVLAVFYTIFTPILNPVIYTLRNKEVK 295
Cdd:cd15136  231 ltaAFGLPLISVSNAKILLVFFYPLNSCANPFLYAIFTKQFR 272

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

29-154

3.18e-03

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 38.65 E-value: 3.18e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15301    5 IVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLAS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15301   85 NASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLL 130

7tmA_Adenosine_R_A1

cd15071

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...

33-154

3.29e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.

Pssm-ID: 341323 [Multi-domain] Cd Length: 290 Bit Score: 38.67 E-value: 3.29e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  33 LLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPkmLADFLVERKTISFEACLAQIFFVHLFTGGEM 112
Cdd:cd15071    9 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAIIINIGPQTEFYSCLMVACPVLILTQSSI 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 282396077 113 VLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15071   87 LALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFL 128

7tmA_Beta2_AR

cd15957

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...

29-151

3.89e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.

Pssm-ID: 341355 [Multi-domain] Cd Length: 301 Bit Score: 38.31 E-value: 3.89e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15957    5 IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCV 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFV 151
Cdd:cd15957   85 TASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIV 127

7tmA_NKR_NK3R

cd16003

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...

29-296

3.90e-03

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320669 [Multi-domain] Cd Length: 282 Bit Score: 38.37 E-value: 3.90e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd16003    5 LAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHymTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCG--------PNKVDSFFCD 180
Cdd:cd16003   85 FASIYSMTAIAVDRYMAIIDPLK--PRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGrtlcfvawPGGPDQHFTY 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 181 LPLVTKLacidTYVVSLLIVAdsgflsmssflllvVSYTVILITV--------RNRSSASMAKARSTLTAHITVVVLFFG 252
Cdd:cd16003  163 HIIVIVL----VYCLPLLVMG--------------ITYTIVGITLwggeipgdTSDKYHEQLRAKRKVVKMMIIVVLTFA 224

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 282396077 253 PCIFIYVWPFSSYSVDK-----------VLAVFYTIFTPIL-NPVIYTLRNKEVKA 296
Cdd:cd16003  225 ICWLPYHIYFIVTGLYQqlnrwkyiqqvYLASFWLAMSSTMyNPIIYCCLNKRFRA 280

7tmA_VA_opsin

cd15082

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...

21-295

4.39e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320210 [Multi-domain] Cd Length: 291 Bit Score: 38.24 E-value: 4.39e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  21 KELQPFLFLIFSLLYLAI----LLGNFLIILTVTSDSRLHTPMYFLLANLSfidmcvasfatpkmLADFLVERK--TISF 94
Cdd:cd15082    6 KSIAPWNFTVLAALMFVVtslsLAENFAVMLVTFRFKQLRQPLNYIIVNLS--------------VADFLVSLTggTISF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  95 ------------EACLAQIFFVHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCIsWFVGFI-------- 154
Cdd:cd15082   72 ltnargyfflgvWACVLEGFAVTFFGIVALWSLAVLAFERFFVICRPLGNIRLQGKHAALGLLFV-WTFSFIwtippvlg 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 155 ---HTTSQLAFTvnlpfCGPNKVDSFFCDlplvtklaciDTYVVSLLIVAdsgflSMSSFLLLVVSYTVILITVRNRSS- 230
Cdd:cd15082  151 wssYTVSKIGTT-----CEPNWYSGNMHD----------HTYIITFFTTC-----FILPLGVIFVSYGKLLQKLRKVSNt 210

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 282396077 231 ----ASMAKARSTLTAHITVVVLFFGPC------IFIYVWPFSSYSVDKVLA---VFYTIFTPILNPVIYTLRNKEVK 295
Cdd:cd15082  211 qgrlGNARKPERQVTRMVVVMIVAFMVCwtpyaaFSILVTAHPTIHLDPRLAaipAFFSKTAAVYNPIIYVFMNKQFR 288

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

30-162

4.62e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 38.24 E-value: 4.62e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIF--FVHLF 107
Cdd:cd15351    6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnVIDTM 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 282396077 108 TGGEMV----LLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAF 162
Cdd:cd15351   86 ICSSVVsslsFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVY 144

7tmA_mAChR

cd15049

muscarinic acetylcholine receptor subfamily, member of the class A family of ...

26-154

4.64e-03

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341322 [Multi-domain] Cd Length: 262 Bit Score: 38.07 E-value: 4.64e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPkMLADFLVERK------------TIS 93
Cdd:cd15049    2 LICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMN-LYTVYLVMGYwplgpllcdlwlALD 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 282396077  94 FEACLAQIffvhlftggeMVLLVsMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15049   81 YVASNASV----------MNLLL-ISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFV 130

7tmA_D1A_dopamine_R

cd15320

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

31-149

4.85e-03

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320443 [Multi-domain] Cd Length: 319 Bit Score: 38.06 E-value: 4.85e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  31 FSLLYLAILLGNFLIILTVTSDSRLHTPMY-FLLANLSFIDMCVASFATP-KMLADFLVERKTISFeaCLAQIFFVHLFT 108
Cdd:cd15320    8 LSVLILSTLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMPwKAVAEIAGFWPFGSF--CNIWVAFDIMCS 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISW 149
Cdd:cd15320   86 TASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAW 126

7tmA_BNGR-A34-like

cd15000

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...

30-154

4.89e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320131 [Multi-domain] Cd Length: 285 Bit Score: 38.18 E-value: 4.89e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTG 109
Cdd:cd15000    5 MFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLL 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 282396077 110 GEMVLLVSMAYDRYVAICKPLHymTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15000   85 ASVLALCAVSYDRLTAIVLPSE--ARLTKRGAKIVIVITWIVGLL 127

7tmA_P2Y6_P2Y3-like

cd15968

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...

26-292

4.92e-03

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).

Pssm-ID: 320634 [Multi-domain] Cd Length: 285 Bit Score: 38.22 E-value: 4.92e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMcVASFATPKMLADFLVERKTISFE-ACLAQIFFV 104
Cdd:cd15968    2 LLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADL-LYALSLPLLIYNYAMRDRWLFGDfMCRLVRFLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTT-----SQLAFTVNLPFCGPNKVDSFFC 179
Cdd:cd15968   81 YFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLpilifARTGIIRNRTVCYDLAPPALFP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 180 DlplvtklacidtYVVSLLIVADSGFLsmSSFLLLVVSYTVILITV----RNRSSASMAKARSTLTAHITVVVLF---FG 252
Cdd:cd15968  161 H------------YVPYGMALTVSGFL--LPFSIILWCYCLVVRTLcrtlGPAEPPAQARRRKSIRTIVTVTLLFalcFL 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 282396077 253 P-----CIFIYVW--PFSSYSVDKVLAVFYTIFTPI------LNPVIYTLRNK 292
Cdd:cd15968  227 PfhitrTIYLAVRvtPGVPCHVLEAVAACYKITRPLasansvLNPLLYFLTKK 279

7tmA_PSP24-like

cd15213

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...

40-297

5.15e-03

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320341 [Multi-domain] Cd Length: 262 Bit Score: 38.12 E-value: 5.15e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  40 LGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGGEMVLLVSMA 119
Cdd:cd15213   16 LGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGVAILLIIS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 120 YDRYVAICKPLHYMTIMSRRVCIIlvcISWFvgfihttsqLAFTVNLPFCGPNKVDSFFCDLPL----VTKLACIDTYVV 195
Cdd:cd15213   96 VDRYLIIVQRQDKLNPHRAKILIA---VSWV---------LSFCVSFPPLVGWGKYEFPPRAPQcvlgYTESPADRIYVV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 196 SLLIvadsgFLSMSSFLLLVVSYTVILITVRNrssasmAKARstltAHITVVVLFFGpciFIYVW-PFSSYS----VDKV 270
Cdd:cd15213  164 LLLV-----AVFFIPFLIMLYSYFCILNTVRS------FKTR----AFTTILILFIG---FSVCWlPYTVYSllsvFSRY 225

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 282396077 271 LAVFYTIFTPIL---------NPVIYTLRNKEVKAA 297
Cdd:cd15213  226 SSSFYVISTCLLwlsylksafNPVIYCWRIKKFREA 261

7tmA_MCHR-like

cd15088

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...

30-289

5.94e-03

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320216 [Multi-domain] Cd Length: 278 Bit Score: 37.82 E-value: 5.94e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMcVASFATPKMLADFLVERKTIsFEACLAQIFFV----H 105
Cdd:cd15088    6 VFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADL-LFMLGMPFLIHQFAIDGQWY-FGEVMCKIITAldanN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 106 LFTGgeMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFcgPNKVDSFFCDLPLVT 185
Cdd:cd15088   84 QFTS--TYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYF--PDGTTFCYVSLPSPD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 186 KLaciDTYVVSLLIVADS-GFLSMSSFLLLVVSYTVILITVRNRSSASMAKARSTLTAhITVVVLFFGPCIFIYV----- 259
Cdd:cd15088  160 DL---YWFTIYHFILGFAvPLVVITVCYILILHRLARGVAPGNQSHGSSRTKRVTKMV-ILIVVVFIVCWLPFHVvqlvn 235

                        250       260       270
                 ....*....|....*....|....*....|....
gi 282396077 260 ----WPFSSYSVDKVLAVFYTIFTPILNPVIYTL 289
Cdd:cd15088  236 lamnRPTLAFEVAYFLSICLGYANSCLNPFVYIL 269

7tmA_CB2

cd15341

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...

26-298

6.63e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320463 [Multi-domain] Cd Length: 279 Bit Score: 37.51 E-value: 6.63e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLH-TPMYFLLANLSFIDMcVASFATPKMLADFLVERKTISFEACLAQIFFV 104
Cdd:cd15341    2 AIAVLCTLCGLLCILENVAVLYLILSSPKLRrKPSYLFIGSLALADF-LASVVFACSFVDFHVFHGVDSSAIFLLKLGGV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 105 HLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGfihttsqlAFTVNLPFCGPN--KVDSFFCDL- 181
Cdd:cd15341   81 TMSFTASLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLT--------ALIAYLPLMGWNccPLNSPCSELf 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 182 PLVTklaciDTYVVSLLIvadsgfLSMSSFLLLVVSY----------TVILITVRNRSSASMAKAR------STLTAHIT 245
Cdd:cd15341  153 PLIP-----NDYLLSWLL------LVAILLSGIIYTYghvlwkahkhVVYMEKHQDQQGPGNARMRldvrlaKTLGLVLA 221

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 282396077 246 VVVLFFGPCIFIYVWPFSSYSVDKVLAVF-----YTIFTPILNPVIYTLRNKEVKAAM 298
Cdd:cd15341  222 VLLICWSPVLALMMHSLFTSLSDHIKKAFafcstLCLVNSMVNPIIYALRSRELRSSL 279

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

30-154

7.12e-03

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 37.47 E-value: 7.12e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  30 IFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVAsFATPKMLADFLVERKTISFEA-CLAQIFFVHLFT 108
Cdd:cd15928    6 VCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIF-LVLPLDLYRLWRYRPWRFGDLlCRLMYFFSETCT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15928   85 YASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIV 130

7tmA_GnRHR-like

cd15195

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...

29-293

8.11e-03

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320323 [Multi-domain] Cd Length: 293 Bit Score: 37.38 E-value: 8.11e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  29 LIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFT 108
Cdd:cd15195    5 LVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGM 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 109 GGEMVLLVSMAYDRYVAICKPLHYMTimSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNK-----VDSFFCDLPL 183
Cdd:cd15195   85 YLSSFMLVVIALDRVFAILSPLSANQ--ARKRVKIMLTVAWVLSALCSIPQSFIFSVLRKMPEQPgfhqcVDFGSAPTKK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 184 VTKLACIDTYVVSLLIvadsgflsmsSFLLLVVSYTVILITV---------------RNRSSASMAKARS-TLTAHITVV 247
Cdd:cd15195  163 QERLYYFFTMILSFVI----------PLIITVTCYLLILFEIskmakrardtpisnrRRSRTNSLERARMrTLRMTALIV 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 282396077 248 VLFF---GP--CIFIYVW--PFSSYSVDKVLAVFYTIF---TPILNPVIYTLRNKE 293
Cdd:cd15195  233 LTFIvcwGPyyVLGLWYWfdKESIKNLPPALSHIMFLLgylNPCLHPIIYGVFMKE 288

7tmA_alpha-2D_AR

cd15324

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

27-297

8.26e-03

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320447 [Multi-domain] Cd Length: 256 Bit Score: 37.16 E-value: 8.26e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  27 LFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHL 106
Cdd:cd15324    3 IVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 107 FTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTvnlpfcgpnKVDSFFCDLPLVTk 186
Cdd:cd15324   83 FCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMT---------KHDEWECLLNDET- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 187 lacidTYVVSLLIVAdsgflsmssflLLVVSYTVILITVRNRSSASMAKARSTLTahITVVVLFFGPCIFIYVWPFSSYS 266
Cdd:cd15324  153 -----WYILSSCTVS-----------FFAPGLIMILVYCKIYRVAKMREKRFTFV--LAVVMGVFVLCWFPFFFTYSLHA 214

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 282396077 267 V--------DKVLAVFYTI--FTPILNPVIYTLRNKEVKAA 297
Cdd:cd15324  215 VcrkrcgipDALFNLFFWIgyCNSSVNPIIYTIFNRDFRKA 255

7tmA_AstC_insect

cd15094

somatostatin-like receptor for allatostatin C, member of the class A family of ...

26-154

8.86e-03

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.

Pssm-ID: 320222 [Multi-domain] Cd Length: 282 Bit Score: 37.45 E-value: 8.86e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  26 FLFLIFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVAsFATPKMLADFLVerKTISFEACLAQIFFV- 104
Cdd:cd15094    2 ISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFL-IGLPFLIVTMIL--KYWPFGAAMCKIYMVl 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 282396077 105 ---HLFTGgeMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFI 154
Cdd:cd15094   79 tsiNQFTS--SFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFL 129

7tmA_HCAR1-3

cd15201

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...

23-287

9.75e-03

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.

Pssm-ID: 320329 [Multi-domain] Cd Length: 281 Bit Score: 37.34 E-value: 9.75e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  23 LQPFLFLIFSLLylaiLLGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVaSFATPkMLADFLVERKTISF--EACLAQ 100
Cdd:cd15201    3 LPPVLILEFVLG----LLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLL-IICLP-FRTDYYLRGKHWKFgdIPCRIV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 101 IFFVHLFTGGEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCIILVCISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFfcd 180
Cdd:cd15201   77 LFMLAMNRAGSIFFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLTIAMTVYLLTKKHLFPRGNATQCESF--- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077 181 lplvtklaCIDTYVVSLLIVADSGFLSMSSFLLLVVSYTVILITV--RNRSSASMAKARSTLTaHITVVVLFFGPCIF-- 256
Cdd:cd15201  154 --------NICTGTDSSSNWHEAMFLLEFFLPLAIILYCSVRIIWqlRGRQLDRHAKIKRAVQ-FIMVVAIVFIICFLps 224

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 282396077 257 ----IYVWPFSSYSVD------KVLAVFY-----TIFTPILNPVIY 287
Cdd:cd15201  225 nvtrIAIWILKHTSNEdcqyyrSVDLAFYitisfTYFNSMLDPVVY 270

7tmA_GPR84-like

cd15210

G protein-coupled receptor 84 and similar proteins, member of the class A family of ...

40-153

9.81e-03

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.

Pssm-ID: 320338 [Multi-domain] Cd Length: 254 Bit Score: 36.86 E-value: 9.81e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282396077  40 LGNFLIILTVTSDSRLHTPMYFLLANLSFIDMCVASFATPKMLADFLVERKTISFEACLAQIFFVHLFTGGEMVLLVSMA 119
Cdd:cd15210   16 PGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLIT 95

                         90       100       110
                 ....*....|....*....|....*....|....
gi 282396077 120 YDRYVAICKPLHYMTIMSRRVCIILVCISWFVGF 153
Cdd:cd15210   96 LNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSF 129

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01