|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
26-936 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 854.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 26 YTDTINLPKTKFPNRLTAAKREEQerlVL----ENKIavsyaYQEQRLAEKGKPTFVLHDGPPYANGQLHMGHAVNKILK 101
Cdd:COG0060 1 YKETLNLPKTDFPMRANLPKREPE---ILkfweENDI-----YEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 102 DITLRQRVAHGQRVNYIPGWDCHGLPIELKAT-----STAPGQ--SAQEIRQKSRAFAWEAIKSQKEEFSSWGILANWqk 174
Cdd:COG0060 73 DIIVRYKTMRGFDVPYVPGWDCHGLPIELKVEkelgiKKKDIEkvGIAEFREKCREYALKYVDEQREDFKRLGVWGDW-- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 175 DNIYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRTALAEAELEYdANHISPSVYVRFALNPSSFDVKDKQIY 254
Cdd:COG0060 151 DNPYLTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEY-KDVTSPSIYVKFPVKDEKALLLLEDAY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 255 ALVWTTTPWTLPSNQAICYNASLEYVIVRLSDrnqDELYLMASALMADFEANTQLK-CEIVQHLSGELLSKLSYNHPIDK 333
Cdd:COG0060 230 LVIWTTTPWTLPANLAVAVHPDIDYVLVEVTG---GERLILAEALVEAVLKELGIEdYEVLATFKGAELEGLRYEHPFYY 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 334 EQSN---LPFFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKCFVNEEGTYTKEAPDFlRGKSVLDqGNSLVLDR 410
Cdd:COG0060 307 VVGYdraHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLF-AGLFVKD-ANPAIIED 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 411 IAED--VVHSSKLEHSYPIDWRTKKPVIIRASEQWFINTEKLKTPAADALEQVEIYPranaeASKKALLTQ-LQKRPYWC 487
Cdd:COG0060 385 LKERgaLLAREKITHSYPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIP-----EWGEGRFGNmLENRPDWC 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 488 ISRQRAWGVPIPVLYSRESGKVVLNSALIEHLCNLLRKEGsIDFWWVKSVEE-LVPEHLLRElhHEAKDLVKGTDILDIW 566
Cdd:COG0060 460 ISRQRYWGVPIPIWVCEDCGELHRTEEVIGSVAELLEEEG-ADAWFELDLHRpFLDETLKCP--KCGGTMRRVPDVLDVW 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 567 FDSGSTWSAVL----GKDKIADLYLEGYDQFTGWFQSSLLMSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQ 642
Cdd:COG0060 537 FDSGSMHFAVLenreELHFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQE 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 643 ITKKYGTDALRWWVASHGTQHmSITVSDKLLQQAAENLCKIRGTMRYLKGVIGEKQSGEKLIRTSDKSYLNRYLLSQLVE 722
Cdd:COG0060 617 VIDKYGADILRLWVASSDYWG-DLRFSDEILKEVRDVYRRLRNTYRFLLANLDDFDPAEDAVPYEDLPELDRWILSRLNE 695
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 723 FESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYCG--DDHELLAIRQTLTHCYQQLCKSLWPIVPFLVEES 800
Cdd:COG0060 696 LIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYTEaaDSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEI 775
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 801 WSYYdtTGGA----FHEQIVQTNPEWQDTKATEVINAAFDVKRLINQ------QAGDVNtWHL-AVTIKGKERSQLDLLR 869
Cdd:COG0060 776 WQNL--PGEAeesvHLADWPEVDEELIDEELEAKWDLVREVRSAVLKaleaarKEKLIR-QPLeAAVVLYADEELAAALE 852
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 870 ELhsplgesvsNSELCEILQVGSVTLLQSHNSDLDIALSKLQISL--------------CPRCRRY--GLEDEQKT-CQR 932
Cdd:COG0060 853 SL---------GDLLAEELNVSEVELVDDAEDLGKDALKALDVEGisvtvevekadgekCERCWHYevGWTPEHEGlCRR 923
|
....
gi 281366294 933 CSDV 936
Cdd:COG0060 924 CVRR 927
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
67-940 |
0e+00 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 729.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 67 QRLAEKGK-PTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKATSTAPGQSAQE-- 143
Cdd:PLN02843 23 KRVSDRNNgESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKVLQSLDQEARKElt 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 144 ---IRQKSRAFAWEAIKSQKEEFSSWGILANWqkDNIYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRTALA 220
Cdd:PLN02843 103 pikLRAKAAKFAKKTVDTQRESFKRYGVWGDW--ENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKPVHWSPSSRTALA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 221 EAELEYDANHISPSVYVRFALN------PSSFDVKDKQIYALVWTTTPWTLPSNQAICYNASLEYVIVRLSDRNQDELY- 293
Cdd:PLN02843 181 EAELEYPEGHVSKSIYVAFPVVspsetsPEELEEFLPGLSLAIWTTTPWTMPANAAVAVNDKLQYSVVEVQSFSEDESTs 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 294 --------------------LMASALMADFEANTQLKCEIVQHLSGELLSKLSYNHPIDKEQSNLpFFDASHVQDSKGTG 353
Cdd:PLN02843 261 ggnkkkrpgnvlkeqqklflIVATDLVPALEAKWGVKLVVLKTFPGSDLEGCRYIHPLYNRESPV-VIGGDYITTESGTG 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 354 LVHTAPAHGPEDFLVSLTQKIPVKCFVNEEGTYTKEAPDFlRGKSVLDQGNSLVLDRIAED--VVHSSKLEHSYPIDWRT 431
Cdd:PLN02843 340 LVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQF-SGLSVLGEGNAAVVEALDEAgsLLMEEAYGHKYPYDWRT 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 432 KKPVIIRASEQWFINTEKLKTPAADALEQVEIYPranaEASKKALLTQLQKRPYWCISRQRAWGVPIPVLYSRESGKVVL 511
Cdd:PLN02843 419 KKPTIFRATEQWFASVEGFRQAALDAIDKVKWIP----AQGENRIRAMVSGRSDWCISRQRTWGVPIPVFYHVETKEPLM 494
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 512 NSALIEHLCNLLRKEGSiDFWWVKSVEELVPEhllrELHHEAKDLVKGTDILDIWFDSGSTWSAVLGKDK----IADLYL 587
Cdd:PLN02843 495 NEETIAHVKSIVAQKGS-DAWWYMDVEDLLPE----KYRDKASDYEKGTDTMDVWFDSGSSWAGVLGSREglsyPADLYL 569
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 588 EGYDQFTGWFQSSLLMSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQI-----TKK----YGTDALRWWVAS 658
Cdd:PLN02843 570 EGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVieggkNQKqepaYGADVLRLWVAS 649
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 659 hgTQHMS-ITVSDKLLQQAAENLCKIRGTMRYLKGVIGEKQSGEKlIRTSDKSYLNRYLLSQLVEFESEVEKLYQAYEYN 737
Cdd:PLN02843 650 --VDYTGdVLIGPQILKQMSDIYRKLRGTLRYLLGNLHDWKPDNA-VPYEDLPSIDKYALFQLENVVNEIEESYDNYQFF 726
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 738 RVVACVQNFIANQVSAVYVHLIKDRLYCG--DDHELLAIRQTLTHCYQQLCKSLWPIVPFLVEESWS---YYDTTGGA-- 810
Cdd:PLN02843 727 KIFQILQRFTIVDLSNFYLDVAKDRLYVGgtTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQnlpFQEDGSAAes 806
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 811 -FHEQIVQTNPEWQDTKATEVI--NAAFDVKRLINQQAGDVNTWHL-------AVTIKGkerSQLDLLRELHSPLGESVS 880
Cdd:PLN02843 807 vFEAGWPTPNEEWLSFPAEDVDfwSLLLEVRDEVNKVLESARNGKLigasleaKVYLHA---SDASLAARLAELCGASNG 883
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 881 NSELCEILQVGSVTLLQSHNSDLD-----------------IALSKLQISLCPRCRRY-----GLEDEQKTCQRCSDVME 938
Cdd:PLN02843 884 ADELRRIFITSQVEVVSSEDDETAacgsytgeyvegagrvwVGVSRADGSKCERCWNYspavgSFSDHPTLCERCYPVVI 963
|
..
gi 281366294 939 AK 940
Cdd:PLN02843 964 AQ 965
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
36-843 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 712.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 36 KFPNRLTAAKREEQerlVL----ENKIavsyaYQEQRLAEKGKPTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAH 111
Cdd:TIGR00392 1 KFPMRGNLSKREEK---ILafwqENDI-----FEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQ 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 112 GQRVNYIPGWDCHGLPIELKA------TSTAPGQSA--QEIRQKSRAFAWEAIKSQKEEFSSWGILANWQKDniYMTFQP 183
Cdd:TIGR00392 73 GFNVTRKPGWDTHGLPIEHKVekklgiSGKKEISSLeiEEFREKCREFALKQIEEQREQFQRLGVWGDWENP--YKTMDP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 184 EFIVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRTALAEAELEYDAN---HISPSVYVRFALNPSSF-DVKDKQIYALVWT 259
Cdd:TIGR00392 151 SYEESQWWLFKEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKENykdVKDPSIYVKFPVKKDKKtYLKVKLSSLLIWT 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 260 TTPWTLPSNQAICYNASLEYVIVRlsDRNQDELYLMASALMADFEANTQLKCEIVQHLSGELLSKLSYNHPI---DKEQS 336
Cdd:TIGR00392 231 TTPWTLPSNLAIAVHPDFEYALVQ--DNTKVEYFILAKKLVEKLYNKAGSDYEIIKTFKGSDLEGLEYEHPLydfVSQLK 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 337 NLPFF--DASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKCFVNEEGTYTKEAPDFlRGKSVLDQG------NSLVL 408
Cdd:TIGR00392 309 EGAPVviGGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDF-QGRFVKDADkdiikaNKIII 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 409 DRIAED--VVHSSKLEHSYPIDWRTKKPVIIRASEQWFINTEKLKTPAADALEQVEIYPranaEASKKALLTQLQKRPYW 486
Cdd:TIGR00392 388 EQLKDKglLLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVP----EWGEGRFGNWLENRPDW 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 487 CISRQRAWGVPIPVLYSRESGKVvLNSALIEHLCNLLRKEGsIDFWWVKSVEELVPEhlLRELHHEAKDLVKGTDILDIW 566
Cdd:TIGR00392 464 CISRQRYWGIPIPIWYCEDTGEP-IVVGSIEELIELIELKG-IDAWFEDLHRDFLDK--ITLKSGDGGEYRRVPDVLDVW 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 567 FDSGSTWSAVLG---------KDKIADLYLEGYDQFTGWFQSSLLMSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNV 637
Cdd:TIGR00392 540 FDSGSMPYASIHypfenekfkEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNV 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 638 ISPKQITKKYGTDALRWWVASHGTQHmSITVSDKLLQQAAENLCKIR-GTMRYL--KGVIGEKQSGEKLIRTSDKSYLNR 714
Cdd:TIGR00392 620 VDPLKVINKYGADILRLYVASSDPWE-DLRFSDEILKQVVEKYRKIRwNTYRFLltYANLDKFDPLFNSVAVEKFPEEDR 698
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 715 YLLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYC-GDDHELLAIRQTLTHCYQQLCKSLWPIV 793
Cdd:TIGR00392 699 WILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVEELSNWYIRIIRDRLYCeAKDNDKRAAQTTLYYALLTLVRLLAPFL 778
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281366294 794 PFLVEESWSYYDTTGGafhEQIVQTNP------------EWQDTK-ATEVINAAFDVKRLINQ 843
Cdd:TIGR00392 779 PHTAEEIYQNLPGGEE---EESVHLNLwpevdeefideaLEANMAiVREIVEAFLALRDAANK 838
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
63-658 |
5.40e-174 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 518.50 E-value: 5.40e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 63 AYQEQRLAEKGKPTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKATST--APGQ- 139
Cdd:pfam00133 11 YFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVEKKlgIKEKk 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 140 -----SAQEIRQKSRAFAWEAIKSQKEEFSSWGILANWQKDniYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPS 214
Cdd:pfam00133 91 trhkyGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDRE--YFTMDPELEAAVWEVFVRLHDKGLIYRGKKLVNWSPA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 215 SRTALAEAELEY-DANhiSPSVYVRFALnpssfdVKDKQIYALVWTTTPWTLPSNQAICYNASLEYVIvrlsdrnQDELY 293
Cdd:pfam00133 169 LNTALSNLEVEYkDVK--GPSIHVAFPL------ADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI-------TGEGY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 294 LMASALMADFEANTQLKcEIVQHLSGELLSKLSYNHPIdkEQSNLPFFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQK 373
Cdd:pfam00133 234 ILAEALLKSLYKKGTDK-KILEDFRGKELEGKEAIHPF--VNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 374 IPVKCFVNEEGTYTKEAPDFlRGKSVLDqGNSLVLDRIAE--DVVHSSKLEHSYPIDWRTKKPVIIRASEQWFINTEKLK 451
Cdd:pfam00133 311 LEVINPVDDDGTFTEEAPDF-QGVYRFD-ARKKIVELLTEkgLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELA 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 452 TPAADALEQVEIYPranaEASKKALLTQLQKRPYWCISRQRAWGVPIPVLYSRESGKVVLNSALIEHLCNLLRKEGSIDf 531
Cdd:pfam00133 389 DQALEAVEKVQFVP----KSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGRFEEEGSIK- 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 532 WWVKSVEELvpehllreLHHEAKDLVKGTDILDIWFDSGSTWSAVLG----------KDKIADLYLEGYDQFTGWFQSSL 601
Cdd:pfam00133 464 WLHREAKDK--------LGYGKGTLEQDEDVLDTWFSSGSWPFSTLGwpfvnteefkKFFPADMLLEGSDQTRGWFYRMI 535
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*..
gi 281366294 602 LMSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVAS 658
Cdd:pfam00133 536 MLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLAN 592
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
71-840 |
1.84e-101 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 336.65 E-value: 1.84e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 71 EKGKPTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELK--ATSTAPGQSAQEI-RQK 147
Cdd:TIGR00422 29 NSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIATQVKveKKLGAEGKTKHDLgREE 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 148 SRAFAWE-------AIKSQkeeFSSWGILANWQKDNIYMTFQPEFIVNqlEMFYNLYEKGLVYRDLKPVYWSPSSRTALA 220
Cdd:TIGR00422 109 FREKIWEwkeesggTIKNQ---IKRLGASLDWSRERFTMDEGLSKAVK--EAFVRLYEKGLIYRGEYLVNWDPKLNTAIS 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 221 EAELEYDANHISPSvYVRFALNPSSFDvkdkqiYALVWTTTPWTLPSNQAICYNAsleyvivrlsdrnQDELYlmasalm 300
Cdd:TIGR00422 184 DIEVEYKEVKGKLY-YIRYPLANGSKD------YLVVATTRPETMFGDTAVAVHP-------------EDERY------- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 301 adfeantqlkceivQHLSGELLSKLSYNHPIdkeqsnlPFFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKCFV 380
Cdd:TIGR00422 237 --------------KHLIGKKVILPLTGRKI-------PIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINIL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 381 NEEGTYTKEAPDFlRGKSVLDQGNSLVLDRIAEDV-VHSSKLEHSYPIDWRTKKPVIIRASEQWFINTEKLKTPAADALE 459
Cdd:TIGR00422 296 DEDGLLNENAGKY-QGLTRFEARKKIVEDLKEEGLlVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAE 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 460 --QVEIYPranaEASKKALLTQLQKRPYWCISRQRAWGVPIPVLYSRESGKVVLnsALIEHLCNLLRKEGSidfwwvksv 537
Cdd:TIGR00422 375 egEIKFVP----KRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECGEVYV--AKEEPLPDDKTNTGP--------- 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 538 eelvpehllrelhheAKDLVKGTDILDIWFDSGSTWSAVLG----KDKIADLY-----LEGYDQFTGWFQSSLLMSIAAR 608
Cdd:TIGR00422 440 ---------------SVELEQDTDVLDTWFSSSLWPFSTLGwpdeTKDLKKFYptdllVTGYDIIFFWVARMIFRSLALT 504
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 609 ECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVASHGTQHMSITVSDKLLQQAAENLCKIRGTMR 688
Cdd:TIGR00422 505 GQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWKRVESARNFLNKLWNASR 584
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 689 YLKGVIGEKQ---SGEKLIRTSDksylnRYLLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYC 765
Cdd:TIGR00422 585 FVLMNLSDDLelsGGEEKLSLAD-----RWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCDWYIELVKYRLYN 659
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 766 GDDHELLAIRQTLTHCYQQLCKSLWPIVPFLVEESWSYYDTTGGAFHEQIV-QTNPEWQDTKATE----VINAAFDVKRL 840
Cdd:TIGR00422 660 GNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGADSIMLQSYpVVDAEFVDEEAEKafelLKEIIVSIRNL 739
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
46-798 |
4.55e-85 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 297.02 E-value: 4.55e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 46 REEQERLVLENKIAvsyAYQEQRLAEKGKPTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHG 125
Cdd:PLN02882 12 KQEEKILSLWSEID---AFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 126 LPIElkatstapgqsaQEIRQKSrafaweAIKSqKEEFSSWGI--------------LANWQK-----------DNIYMT 180
Cdd:PLN02882 89 LPVE------------YEIDKKL------GIKR-RDDVLKMGIdkyneecrsivtrySKEWEKtvtrtgrwidfENDYKT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 181 FQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRTALA--EAELEYDANHiSPSVYVRFALnpssfdVKDKQIYALV- 257
Cdd:PLN02882 150 MDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSnfEAGLNYKDVS-DPAVMVSFPI------VGDPDNASFVa 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 258 WTTTPWTLPSNQAICYNASLEYVIVRlsDRNQDELYLMASALMADF--EANTQLKCEIVQHLSG--ELLSKLSYNHPIDK 333
Cdd:PLN02882 223 WTTTPWTLPSNLALCVNPNFTYVKVR--NKYTGKVYIVAESRLSALptAKPKSKKGSKPENAAEgyEVLAKVPGSSLVGK 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 334 EQSNL-PFFDA-----------SHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVK-----CFVNEEGTYTKEAPDFlRG 396
Cdd:PLN02882 301 KYEPLfDYFSEfsdtafrvvadDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIIEKggnlpVPVDDDGCFTEKVTDF-SG 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 397 KSVLDQGNSLV-LDRIAEDVVHSSKLEHSYPIDWRTKKPVIIRASEQWFINTEKLKTPAADALEQVEIYPranAEASKKA 475
Cdd:PLN02882 380 RYVKDADKDIIaAIKAKGRLVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVP---DYVKEKR 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 476 LLTQLQKRPYWCISRQRAWGVPIPVLYSRESGKVVLnsaliehlcnllrkegsidfwwVKSVEELvpEHL----LRELHH 551
Cdd:PLN02882 457 FHNWLENARDWAVSRSRFWGTPLPIWISDDGEEVVV----------------------IGSIAEL--EKLsgvkVTDLHR 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 552 EAKD--------------LVKGTDILDIWFDSGSTWSA----------VLGKDKIADLYLEGYDQFTGWFQSSLLMSIAA 607
Cdd:PLN02882 513 HFIDhitipssrgpefgvLRRVDDVFDCWFESGSMPYAyihypfenkeLFEKNFPADFVAEGLDQTRGWFYTLMVLSTAL 592
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 608 RECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVAShgtqhmSITVSdkllqqaAENL-CKIRGT 686
Cdd:PLN02882 593 FDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLIN------SPVVR-------AEPLrFKEEGV 659
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 687 MRYLKGVI----------------GEKQSGEKLIRT------SDKSYLNRYLLSQ---LVEFeseVEKLYQAYEYNRVVA 741
Cdd:PLN02882 660 FGVVKDVFlpwynayrflvqnakrLEVEGGAPFVPLdlaklqNSANVLDRWINSAtqsLVKF---VREEMGAYRLYTVVP 736
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*....
gi 281366294 742 CVQNFIaNQVSAVYVHLIKDRL--YCGDDHELLAIrQTLTHCYQQLCKSLWPIVPFLVE 798
Cdd:PLN02882 737 YLVKFI-DNLTNIYVRFNRKRLkgRTGEEDCRTAL-STLYNVLLTSCKVMAPFTPFFTE 793
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
33-837 |
1.46e-80 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 278.23 E-value: 1.46e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 33 PKTKFPNRLTAAKREEQ-ERLVLENKIavsYAYQEqrlaEKGKPTFVLHDGPPYANGQLHMGHAVNKILKDItlrqrVAH 111
Cdd:PRK13208 2 MMPELPKKYDPEELEEKwQKIWEEEGT---YKFDP----DERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDF-----IAR 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 112 GQRVN----YIP-GWDCHGLPIELKATSTApGQSAQEI-----RQKSRAFAWEAIKSQKEEFSSWGILANWqkDNIYMTF 181
Cdd:PRK13208 70 YQRMRgynvFFPqGWDDNGLPTERKVEKYY-GIRKDDIsreefIELCRELTDEDEKKFRELWRRLGLSVDW--SLEYQTI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 182 QPEFI-VNQLeMFYNLYEKGLVYRDLKPVYWSPSSRTALAEAELEYDANhisPSVYVRFAlnpssFDVKD-KQIYalVWT 259
Cdd:PRK13208 147 SPEYRrISQK-SFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYRER---EGKLNYIK-----FPVEDgEEIE--IAT 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 260 TTPWTLPSNQAICYNasleyvivrlsdrNQDELYlmasalmadfeantqlkceivQHLSG-ELLSKLsYNH--PI--DKE 334
Cdd:PRK13208 216 TRPELLPACVAVVVH-------------PDDERY---------------------KHLVGkTAIVPL-FGVevPIlaDPL 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 335 qsnlpffdashVQDSKGTGLVhtapahgpedfLVS-----------LTQKIPVKCFVNEEGTYTKEApDFLRGKSVLDqg 403
Cdd:PRK13208 261 -----------VDPDFGTGAV-----------MICtfgdktdvtwwRELNLPTRIIIDEDGRMTEAA-GKLAGLTIEE-- 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 404 nslVLDRIAED------VVHSSKLEHSYPIDWRTKKPVIIRASEQWFINTEKLKTPAADALEQVEIYPranaEASKKALL 477
Cdd:PRK13208 316 ---ARKKIVEDlksgglLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYP----EHMRVRLE 388
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 478 ---TQLQKRpyWCISRQRAWGVPIPVLYSRESGKVVLnsALIEHLcnllrkegSIDFW-----W----VKSVEELVPEhl 545
Cdd:PRK13208 389 nwiEGLNWD--WCISRQRYFGTPIPVWYCKDCGHPIL--PDEEDL--------PVDPTkdeppGykcpQCGSPGFEGE-- 454
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 546 lrelhheakdlvkgTDILDIWFDSGSTWSAVLG--KDKI-------ADLYLEGYDQFTGWFQSSLLMSIAARECAPYKAL 616
Cdd:PRK13208 455 --------------TDVMDTWATSSITPLIVTGweRDEDlfekvfpMDLRPQGHDIIRTWLFYTILRAYLLTGKLPWKNI 520
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 617 FVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVAS--HGTQHM---SITVSDKLLQQAAENLCkirgtmRYLK 691
Cdd:PRK13208 521 MISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVRYWAASarLGSDTPfdeKQVKIGRRLLTKLWNAS------RFVL 594
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 692 GvIGEKQSGEKLIRTSDksyLNRYLLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYCGDDHEL 771
Cdd:PRK13208 595 H-FSADPEPDKAEVLEP---LDRWILAKLAKVVEKATEALENYDFAKALEEIESFFWHVFCDDYLELVKSRAYGEDEEEE 670
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281366294 772 -LAIRQTLTHCYQQLCKSLWPIVPFLVEESWSYYDttGGAFH-EQIVQTNPEWQDTKATEVINAAFDV 837
Cdd:PRK13208 671 qKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLY--GGSVHrASWPEPDEELIDEEDEELGELAKEI 736
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
434-658 |
9.48e-70 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 235.20 E-value: 9.48e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 434 PVIIRASEQWFINTEKLKTPAADALEQVEIYPranaEASKKALLTQLQKRPYWCISRQRAWGVPIPVLYSRESGKVVLns 513
Cdd:cd00818 144 PLIYRATPQWFIRVTKIKDRLLEANDKVNWIP----EWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLV-- 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 514 aliehlcnllrkegsidfwwvksveelvpehllrelhheakdlVKGTDILDIWFDSGSTWSAVLG---------KDKIAD 584
Cdd:cd00818 218 -------------------------------------------RRVPDVLDVWFDSGSMPYAQLHypfenedfeELFPAD 254
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281366294 585 LYLEGYDQFTGWFQSSLLMSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVAS 658
Cdd:cd00818 255 FILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVAS 328
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
70-801 |
1.47e-60 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 224.49 E-value: 1.47e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 70 AEKGKPTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIEL---KATSTAPGQSAQEIRQ 146
Cdd:PRK14900 43 HDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQMiveKELKKTEKKSRHDLGR 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 147 KS---RAFAWEAIKSQK--EEFSSWGILANWQKDNIYMTFQPEFIVNqlEMFYNLYEKGLVYRDLKPVYWSPSSRTALAE 221
Cdd:PRK14900 123 EAfleRVWAWKEQYGSRigEQHKALGASLDWQRERFTMDEGLSRAVR--EVFVRLHEEGLIYREKKLINWCPDCRTALSD 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 222 AELEYDANHISPSVYVRFALnpssfdvKDKQIYALVWTTTPWTLPSNQAICYNAsleyvivrlsdrnQDELYlmasalma 301
Cdd:PRK14900 201 LEVEHEEAHQGELWSFAYPL-------ADGSGEIVVATTRPETMLGDTAVAVHP-------------LDPRY-------- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 302 dfeantqlkceivQHLSGEllsklSYNHPI-DKEqsnLPFF-DASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKCF 379
Cdd:PRK14900 253 -------------MALHGK-----KVRHPItGRT---FPIVaDAILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 380 VNEEGTYTKEAPDFlrgkSVLD--QGNSLVLDRIAEDVVHSSKLEHSYPID--WRTKKPVIIRASEQWFINTEKLKTPAA 455
Cdd:PRK14900 312 IGPDGRMTAEAGPL----AGLDrfEARKEVKRLLAEQGLDRGAKPHVLPLGrcQRSATILEPLLSDQWYVRIEPLARPAI 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 456 DALEQVEIypRANAEASKKALLTQLQKRPYWCISRQRAWGVPIPVLYSRESGKVVLNSAliEHLCnllRKEGSidfwwvk 535
Cdd:PRK14900 388 EAVEQGRT--RFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHVTVARET--PEAC---STCGK------- 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 536 sveelvpehllrelhheaKDLVKGTDILDIWFDSG----STWSAVLGKDKIADLY----LE-GYDQFTGWFQSSLLMSIA 606
Cdd:PRK14900 454 ------------------AELRQDEDVLDTWFSSGlwpfSTMGWPEQTDTLRTFYptsvMEtGHDIIFFWVARMMMMGLH 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 607 ARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVASHGTQHMSITVSDKLLQQAAENLCKIRGT 686
Cdd:PRK14900 516 FMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDIKLAKERIEGYRAFANKLWNA 595
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 687 MRY-LKGVIGEKQSGEKLIRTSdKSYLNRYLLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYC 765
Cdd:PRK14900 596 SRFaLMNLSGYQERGEDPARLA-RTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYIELAKEALAS 674
|
730 740 750
....*....|....*....|....*....|....*.
gi 281366294 766 GDDHELLAIRQTLTHCYQQLCKSLWPIVPFLVEESW 801
Cdd:PRK14900 675 EDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELW 710
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
48-798 |
2.97e-60 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 224.08 E-value: 2.97e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 48 EQERLVLENKIAVSYAYQEQRLAEKGKPtFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLP 127
Cdd:PTZ00427 76 EEEEKVLKYWKSIDAFNTSNKLAKNKKA-YIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLP 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 128 IELKATSTAPGQSAQEI--------RQKSRAFAweaIKSQKEEFSSWGILANW-QKDNIYMTFQPEFIVNQLEMFYNLYE 198
Cdd:PTZ00427 155 IEYEIEKENNINKKEDIlkmgidvyNEKCRGIV---LKYSNEWVKTVERIGRWiDFKNDYKTMDKTFMESVWWVFSELYK 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 199 KGLVYRDLKPVYWSPSSRTALAEAELEYDANHI-SPSVYVRFALNPSSFDVK-------DKQIYA--------------- 255
Cdd:PTZ00427 232 NNYVYKSFKVMPYSCKCNTPISNFELNLNYKDTpDPSIIISFVLCSDFPKVEeecnieeDKQLLGekysvlynnkrensn 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 256 ------------------LVWTTTPWTLPSNQAICYNASLEYVivRLSDRNQDELYLMASA----LMADFEANTQlKCEI 313
Cdd:PTZ00427 312 ngnnnstnnvcyaqhseiLAWTTTPWTLPSNLALCVNEHFTYL--RIHHVKSNRVVIVGECrlewIMKELKWNVE-DLKI 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 314 VQHLSGELLSKLSY----NHPIDK---EQSNLPFFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKI--PVKC------ 378
Cdd:PTZ00427 389 VNRFKGKELKGLRYkplfTNFYEKynfKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidPEKNifidpl 468
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 379 -----FVNE----EGTYTKEAPDFLRGKsvLDQGNSLVldriaedvvHSSKLEHSYPIDWRTKKPVIIRASEQWFInteK 449
Cdd:PTZ00427 469 dangyFTNEveevQNLYIKEADNVIKKK--LKNENRLL---------SNNTIVHSYPFCWRSDTPLIYRAIPAWFI---R 534
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 450 LKTPAADALEQVEIYPRANAEASKKALLTQLQKRPYWCISRQRAWGVPIPVlYSRESGKVVLNSALIEHLCNLlrkEGsi 529
Cdd:PTZ00427 535 VSNSTNELVKNNETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPI-WADEKMETVICVESIKHLEEL---SG-- 608
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 530 dfwwVKSVEELvPEHLLRELH------HEAKDLVKGTDILDIWFDSGS-----------TWSAVLGKDKIADLYLEGYDQ 592
Cdd:PTZ00427 609 ----VKNINDL-HRHFIDHIEiknpkgKTYPKLKRIPEVFDCWFESGSmpyakvhypfsTEKEDFHKIFPADFIAEGLDQ 683
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 593 FTGWFQSSLLMSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALR-WWVASHGTQHMSITVSDK 671
Cdd:PTZ00427 684 TRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRlYLINSVAVRAENLKFQEK 763
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 672 LLQQAAEN-LCKIRGTMRYLKGVIGEKQSGEKLIRTSDKSY-------LNRYLLSQLVEFESEVEKLYQAYEYNRVVACV 743
Cdd:PTZ00427 764 GVNEVVKSfILPFYHSFRFFSQEVTRYECLNKKQFLFNTDYiykndniMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKL 843
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281366294 744 QNFIANqVSAVYVHLIKDRLycgddhellaiRQTL--THCYQQLC---KSLW-------PIVPFLVE 798
Cdd:PTZ00427 844 LQFIEN-LTNWYIRLNRDRM-----------RGSLgeENCLQSLCttyRTLHlftvlmaPFTPFITE 898
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
83-841 |
1.25e-56 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 210.73 E-value: 1.25e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 83 PPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDcH-GlpI--------ELKATstapGQSAQEI-RQK--SRA 150
Cdd:PRK05729 44 PPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTD-HaG--IatqmvverQLAAE----GKSRHDLgREKflEKV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 151 FAWeaiksqKEEfsSWGIlanwqkdniymtfqpefIVNQL-------------------------EMFYNLYEKGLVYRD 205
Cdd:PRK05729 117 WEW------KEE--SGGT-----------------ITNQLrrlgascdwsrerftmdeglskavrEVFVRLYEKGLIYRG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 206 LKPVYWSPSSRTALAEAELEY--DANHIspsVYVRFALnpssfdvKDKQIYALVWTTTPWTLPSNQAICYNASleyvivr 283
Cdd:PRK05729 172 KRLVNWDPKLQTALSDLEVEYkeVKGKL---WHIRYPL-------ADGSDYLVVATTRPETMLGDTAVAVNPE------- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 284 lsdrnqDELYlmasalmadfeantqlkceivQHLSGELLsklsyNHPI-DKEqsnLPFFDASHVQDSKGTGLVHTAPAHG 362
Cdd:PRK05729 235 ------DERY---------------------KHLIGKTV-----ILPLvGRE---IPIIADEYVDPEFGTGAVKITPAHD 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 363 PEDFLVSLTQKIPVKCFVNEEGTYTKEAPDFlRGKSVLD-----------QGnslVLDRIaEDVVHSskLEHSYpidwRT 431
Cdd:PRK05729 280 PNDFEVGKRHNLPMINIMDEDGTINENPGEY-QGLDRFEarkaivadleeLG---LLVKI-EPHTHS--VGHSD----RS 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 432 KKPVIIRASEQWFINTEKLKTPAADALE--QVEIYPranaEASKKALLTQLQK-RPyWCISRQRAWGVPIPVLYSrESGK 508
Cdd:PRK05729 349 GVVIEPYLSDQWFVKMKPLAKPALEAVEngEIKFVP----ERWEKTYFHWMENiQD-WCISRQLWWGHRIPAWYD-EDGE 422
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 509 VVlnsaliehlcnllrkegsidfwwvksVEELVPEHLlrelhhEAKDLVKGTDILDIWFDSG----STwsavLG-KDKIA 583
Cdd:PRK05729 423 VY--------------------------VGREEPEAR------EKALLTQDEDVLDTWFSSAlwpfST----LGwPEKTE 466
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 584 DLylegyDQFtgwFQSSLL----------------MSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITKKY 647
Cdd:PRK05729 467 DL-----KRF---YPTSVLvtgfdiiffwvarmimMGLHFTGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKY 538
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 648 GTDALRWWVASHGTQHMSITVSDKLLQQAAeNLC-KIRGTMRYLKGVIGEKQSGEkLIRTSDKSYLNRYLLSQLVEFESE 726
Cdd:PRK05729 539 GADALRFTLAALASPGRDIRFDEERVEGYR-NFAnKLWNASRFVLMNLEGADVGE-LPDPEELSLADRWILSRLNRTVAE 616
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 727 VEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYcgdDHELLAIRQTLTHCYQQLCKSLWPIVPFLVEESWSYydT 806
Cdd:PRK05729 617 VTEALDKYRFDEAARALYEFIWNEFCDWYLELAKPVLQ---EAAKRATRATLAYVLEQILRLLHPFMPFITEELWQK--L 691
|
810 820 830
....*....|....*....|....*....|....*.
gi 281366294 807 TGGAFHEQIVQTN-PEWQDTKATEVINAAFDVKRLI 841
Cdd:PRK05729 692 APLGIEESIMLAPwPEADEAIDEAAEAEFEWLKELI 727
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
83-841 |
1.59e-53 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 201.43 E-value: 1.59e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 83 PPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDcH-GlpI--------ELKATstapGQSAQEI-RQK--SRA 150
Cdd:COG0525 43 PPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD-HaG--IatqavverQLAEE----GKSRHDLgREKflERV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 151 FAWeaiksqKEEfsSWGIlanwqkdniymtfqpefIVNQL-------------------------EMFYNLYEKGLVYRD 205
Cdd:COG0525 116 WEW------KEE--SGGT-----------------ITNQLrrlgascdwsrerftmdeglskavrEVFVRLYEKGLIYRG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 206 LKPVYWSPSSRTALAEAELEY--DANHIspsVYVRFALnpssfdvKDKQIYALVWTTTPWTLPSNQAICYN------ASL 277
Cdd:COG0525 171 KRLVNWDPKLKTALSDLEVEHeeVKGHL---WHIRYPL-------ADGSGYIVVATTRPETMLGDTAVAVHpederyKHL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 278 --EYVIVRLSDRnqdelylmasalmadfeantqlkcEIvqhlsgellsklsynhPIdkeqsnlpFFDaSHVQDSKGTGLV 355
Cdd:COG0525 241 igKTVILPLVGR------------------------EI----------------PI--------IAD-EYVDPEFGTGAV 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 356 HTAPAHGPEDFLVSLTQKIPVKCFVNEEGTYTKEAPDFlRGKSVLD-----------QGnslVLDRIaEDVVHSskLEHS 424
Cdd:COG0525 272 KITPAHDPNDFEVGKRHNLPMINILDEDGTINENAGKY-RGLDRFEarkaivadleeLG---LLVKV-EPHKHS--VGHS 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 425 YpidwRTKkpVII--RASEQWFINTEKLKTPAADALEQ--VEIYPranaEASKKALLTQLQK-RPyWCISRQRAWGVPIP 499
Cdd:COG0525 345 D----RSG--TVIepYLSDQWFVKMKPLAKPAIEAVEDgeIKFVP----ERWEKTYFHWMENiRD-WCISRQLWWGHRIP 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 500 VLYSrESGKVVlnsaliehlcnllrkegsidfwwvksVEELVPEHLLrelHHEAKDLVKGTDILDIWFDSG----STwsa 575
Cdd:COG0525 414 AWYC-PDGEVY--------------------------VARTEPEACA---KAGSVNLTQDEDVLDTWFSSAlwpfST--- 460
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 576 vLG-KDKIADLylegyDQFtgwFQSSLL----------------MSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVI 638
Cdd:COG0525 461 -LGwPEKTEDL-----KYF---YPTSVLvtgfdiiffwvarmimMGLHFTGEVPFKDVYIHGLVRDEQGRKMSKSKGNVI 531
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 639 SPKQITKKYGTDALRWWVASHGTQHMSITVSDKLLQQAAeNLC-KIRGTMRYLKGViGEKQSGEKLIRTSDKSYLNRYLL 717
Cdd:COG0525 532 DPLDLIDKYGADALRFTLAALASPGRDIKFDEERVEGYR-NFAnKLWNASRFVLMN-LEGFDPGLDPDPEELSLADRWIL 609
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 718 SQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYCGDDHELLAIRQTLTHCYQQLCKSLWPIVPFLV 797
Cdd:COG0525 610 SRLNKTIAEVTEALEKYRFDEAAQALYDFVWNEFCDWYLELAKPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFIT 689
|
810 820 830 840
....*....|....*....|....*....|....*....|....*..
gi 281366294 798 EESWSyydTTGGAFHEQ--IVQTNPEWQDTKATEVINAAFD-VKRLI 841
Cdd:COG0525 690 EEIWQ---KLPPRKEGEsiMLAPWPEADEELIDEEAEAEFEwLKEVI 733
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
75-211 |
4.00e-51 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 183.20 E-value: 4.00e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 75 PTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKAT----STAPGQ----SAQEIRQ 146
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEkelgISGKKDiekmGIAEFNA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281366294 147 KSRAFAWEAIKSQKEEFSSWGILANWqkDNIYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYW 211
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDW--ENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW 143
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
668-842 |
3.70e-49 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 171.94 E-value: 3.70e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 668 VSDKLLQQAAENLCKIRGTMRYLKGVIGEKQSGEKLIRTSDKSYLNRYLLSQLVEFESEVEKLYQAYEYNRVVACVQNFI 747
Cdd:cd07960 1 ISDEILKQVAEAYRKIRNTFRFLLGNLNDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 748 ANQVSAVYVHLIKDRLYCG--DDHELLAIRQTLTHCYQQLCKSLWPIVPFLVEESWSYYDTTGGA---FHEQIVQTNPEW 822
Cdd:cd07960 81 TVDLSAFYLDIIKDRLYCDakDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKKEesvFLEDWPELPEEW 160
|
170 180
....*....|....*....|
gi 281366294 823 QDTKATEVINAAFDVKRLIN 842
Cdd:cd07960 161 KDEELEEKWEKLLALRDEVN 180
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
70-801 |
7.62e-47 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 181.68 E-value: 7.62e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 70 AEKGKPTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKATSTAPGQSAQEIRQKSR 149
Cdd:PLN02943 83 FDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVVEKMLASEGIKRTDLGRD 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 150 AFA---WE-------AIKSQKEEFsswGILANWQKDNIYMTFQPEFIVnqLEMFYNLYEKGLVYRDLKPVYWSPSSRTAL 219
Cdd:PLN02943 163 EFTkrvWEwkekyggTITNQIKRL---GASCDWSRERFTLDEQLSRAV--VEAFVRLHEKGLIYQGSYMVNWSPNLQTAV 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 220 AEAELEYdANHISPSVYVRFALNPSSFDvkdkqiYALVWTTTPWTLPSNQAICYNAsleyvivrlsdrnQDELYLMASAL 299
Cdd:PLN02943 238 SDLEVEY-SEEPGTLYYIKYRVAGGSED------FLTIATTRPETLFGDVAIAVNP-------------EDDRYSKYIGK 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 300 MAdfeantqlkceIVQHLSGEllsklsynhpidkeqsNLPFFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKCF 379
Cdd:PLN02943 298 MA-----------IVPMTYGR----------------HVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNV 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 380 VNEEGTYTKEApdflrGKSVLDQGNSLVLDrIAEDVVHSSKLEHSY--PIDWRTKKPVIIRASEQWFINTEKLKTPAADA 457
Cdd:PLN02943 351 MNKDGTLNEVA-----GLYWFEAREKLWSD-LEETGLAVKKEPHTLrvPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKA 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 458 LE--QVEIYPranaEASKKALLTQLQKRPYWCISRQRAWGVPIPVLYsresgkvvlnsaliehlcnLLRKEGSIDFWWVK 535
Cdd:PLN02943 425 VEngELTIIP----ERFEKIYNHWLSNIKDWCISRQLWWGHRIPVWY-------------------IVGKDCEEDYIVAR 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 536 SVEELVPEhlLRELHHEAKDLVKGTDILDIWFDSG----ST--WSAVLGKDkIADLY----LE-GYDQFTGWFQSSLLMS 604
Cdd:PLN02943 482 SAEEALEK--AREKYGKDVEIYQDPDVLDTWFSSAlwpfSTlgWPDVSAED-FKKFYpttvLEtGHDILFFWVARMVMMG 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 605 IAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVAShGTQHMSITVSDKLLQQAAENLCKIR 684
Cdd:PLN02943 559 IEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLAL-GTAGQDLNLSTERLTSNKAFTNKLW 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 685 GTMRYLKGVIGEKQ--SGEKLIRT----SDKSYLN-----RYLLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSA 753
Cdd:PLN02943 638 NAGKFVLQNLPSQSdtSAWEHILAckfdKEESLLSlplpeCWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSDFAD 717
|
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 281366294 754 VYVHLIKDRLY-CGDDHELLAIRQTLTHCYQQLCKSLWPIVPFLVEESW 801
Cdd:PLN02943 718 WYIEASKTRLYhSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELW 766
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
66-841 |
2.22e-40 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 161.33 E-value: 2.22e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 66 EQRLAEKGKPTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLpielkATSTA--------P 137
Cdd:PTZ00419 51 EDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGI-----ATQVVvekklmkeE 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 138 GQSAQEI-RQK--SRAFAWE-----AIKSQkeeFSSWGILANWQKDNIYMTFQPEFIVNqlEMFYNLYEKGLVYRDLKPV 209
Cdd:PTZ00419 126 NKTRHDLgREEflKKVWEWKdkhgnNICNQ---LRRLGSSLDWSREVFTMDEQRSKAVK--EAFVRLYEDGLIYRDTRLV 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 210 YWSPSSRTALAEAELEYDanHISPSVYVRF----------ALNPSSFDVKDK-QIYALVWTTTPWTLPSNQAICYNAsle 278
Cdd:PTZ00419 201 NWCCYLKTAISDIEVEFE--EIEKPTKITIpgydkkvevgVLWHFAYPLEDSgQEEIVVATTRIETMLGDVAVAVHP--- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 279 yvivrlsdrnQDELYlmasalmadfeantqlkceivQHLSG-ELLsklsynHPIDKEQSNLPFFDASHVQDSKGTGLVHT 357
Cdd:PTZ00419 276 ----------KDERY---------------------KKLHGkELI------HPFIPDRKIPIIADDELVDMEFGTGAVKI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 358 APAHGPEDFLVSLTQKIPVKCFVNEEGTYTKEAPDFlRGKSVLDqGNSLVLDRIAEDVVHSSKLEHSY--PIDWRTK--- 432
Cdd:PTZ00419 319 TPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEF-AGMHRFD-CRRKIEEELKEMGLLRDKVPNPMrlPRCSRSGdiv 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 433 KPVIIrasEQWFINTEKLKTPAADALEQVE--IYPrANAEASKKALLTQLQKrpyWCISRQRAWGVPIPVlYsRESGKVV 510
Cdd:PTZ00419 397 EPMLI---PQWYVNCKDMAKRAVEAVRNGElkIIP-SSHENVWYHWLENIQD---WCISRQLWWGHRIPA-Y-RVISKGP 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 511 LNSALIEhlcnllrkegsiDFWWVKSVEElvpehllrELHHEAKD----------LVKGTDILDIWFDSGSTWSAVLG-K 579
Cdd:PTZ00419 468 ETDPSDE------------EPWVVARSEE--------EALEKAKKkfglseedfeLEQDEDVLDTWFSSGLFPFSTLGwP 527
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 580 DKIADL-------YLE-GYDQFTGWFQSSLLMSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISP----------- 640
Cdd:PTZ00419 528 DQTDDLqrffptsLLEtGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPleviegislqd 607
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 641 -------------------KQITKKY-------GTDALRWWVASHGTQHMSITVS-----------DKLLQQAAENLCKI 683
Cdd:PTZ00419 608 lnqklyegnlpekeikraiELQKKEFpngipecGTDALRFGLLAYTQQGRNINLDinrvvgyrhfcNKLWNAVKFALMKL 687
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 684 RGTMRYLKGVIGEKQSGEKLirtsdkSYLNRYLLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRL 763
Cdd:PTZ00419 688 LKDFNLPNSTLFKPNNVESL------PWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRL 761
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 764 YCGDDHE--LLAIrQTLTHCYQQLCKSLWPIVPFLVEESWSY---YDTTggafHEQIV-----QTNPEWQDTKATEVINA 833
Cdd:PTZ00419 762 SKQSDGErkQHAQ-DVLHTVLDIGLRLLHPMMPFITEELYQRlpnYLRK----SESISiakypQPNPGWNNEALDEEMKI 836
|
....*...
gi 281366294 834 AFDVKRLI 841
Cdd:PTZ00419 837 IMSIVKSI 844
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
429-662 |
2.57e-38 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 147.39 E-value: 2.57e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 429 WRTKKPVIIRASEQWFINTEKLKTPAADALEQ--VEIYPranaEASKKALLTQLQKRPYWCISRQRAWGVPIPVLYSRES 506
Cdd:cd00817 157 SRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEgdIKFVP----ERMEKRYENWLENIRDWCISRQLWWGHRIPAWYCKDG 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 507 GKvvlnsaliehlcnllrkegsidfWWVKSVEELV--PEHLLRELHHEAKDLVKGTDILDIWFDSGSTWSAVLG------ 578
Cdd:cd00817 233 GH-----------------------WVVAREEDEAidKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGwpeetk 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 579 -KDKI--ADLYLEGYDQFTGWFQSSLLMSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWW 655
Cdd:cd00817 290 dLKKFypTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFT 369
|
....*..
gi 281366294 656 VASHGTQ 662
Cdd:cd00817 370 LASAATQ 376
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
70-801 |
3.11e-36 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 148.51 E-value: 3.11e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 70 AEKGKPTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLpielkATSTAPGQSAQEIRQKSR 149
Cdd:PLN02381 123 AKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGI-----ATQVVVEKKLMRERHLTR 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 150 ------AFAWEAIKSQKE-------EFSSWGILANWQKDNIYMTFQPEFIVnqLEMFYNLYEKGLVYRDLKPVYWSPSSR 216
Cdd:PLN02381 198 hdigreEFVSEVWKWKDEyggtilnQLRRLGASLDWSRECFTMDEQRSKAV--TEAFVRLYKEGLIYRDIRLVNWDCTLR 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 217 TALAEAELEYdanhispsvyvrfalnpssFDVKDKQIYALVWTTTP--WTLPSNQAICYNASLEYVIVRlSDRNQDELYL 294
Cdd:PLN02381 276 TAISDVEVDY-------------------IDIKERTLLKVPGYDKPveFGVLTSFAYPLEGGLGEIVVA-TTRIETMLGD 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 295 MASALMADFEAntqlkceiVQHLSGELLsklsyNHPIDKEQsnLPFF-DASHVQDSKGTGLVHTAPAHGPEDFLVSLTQK 373
Cdd:PLN02381 336 TAIAIHPDDER--------YKHLHGKFA-----VHPFNGRK--LPIIcDAILVDPNFGTGAVKITPAHDPNDFEVGKRHN 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 374 IPVKCFVNEEGTYTKEA-------PDFLRGKSVLDQGNSLVLDRIAEdvvhssKLEHSYPIDWRTKKPVIIRASEQWFIN 446
Cdd:PLN02381 401 LEFINIFTDDGKINSNGgsefagmPRFAAREAVIEALQKKGLYRGAK------NNEMRLGLCSRTNDVVEPMIKPQWFVN 474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 447 TEKLKTPAADAL-----EQVEIYPRaNAEASKKALLTQLQKrpyWCISRQRAWGVPIPVLYsresgkVVLNSaliehlcN 521
Cdd:PLN02381 475 CSSMAKQALDAAidgenKKLEFIPK-QYLAEWKRWLENIRD---WCISRQLWWGHRIPAWY------VTLED-------D 537
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 522 LLRKEGSI-DFWWVKSVEELVPEHLLRELHHEAKDLVKGTDILDIWFDSGSTWSAVLG-KDKIADL-------YLE-GYD 591
Cdd:PLN02381 538 QLKELGSYnDHWVVARNESDALLEASQKFPGKKFELSQDPDVLDTWFSSGLFPLSVLGwPDDTDDLkafyptsVLEtGHD 617
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 592 QFTGWFQSSLLMSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITK-------------------------- 645
Cdd:PLN02381 618 ILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINgisleglhkrleegnldpkelvvake 697
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 646 -----------KYGTDALRWWVASHGTQHMSITVSDKLLQQAAENLCKIRGTMRYLKGVIGEKQSGEKLIRTSDKSYLNR 714
Cdd:PLN02381 698 gqkkdfpngiaECGTDALRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMSKLGDDYTPPATLSVETMPFSCK 777
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 715 YLLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDrLYCGDDHELL----AIRQTLTHCYQQLCKSLW 790
Cdd:PLN02381 778 WILSVLNKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKP-YFAGDNPEFAseraAAQDTLWICLDTGLRLLH 856
|
810
....*....|.
gi 281366294 791 PIVPFLVEESW 801
Cdd:PLN02381 857 PFMPFVTEELW 867
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
429-658 |
5.03e-36 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 138.71 E-value: 5.03e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 429 WRTKKPViiRASEQWFINTEKLKTPAADALEQVEIYPranaEASKKALLTQLQKRPYWCISRQRAWGVPIPvlysresgk 508
Cdd:cd00668 130 YRGTHPV--RITEQWFFDMPKFKEKLLKALRRGKIVP----EHVKNRMEAWLESLLDWAISRQRYWGTPLP--------- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 509 vvlnsaliehlcnllrkegsidfwwvksveelvpehllrelhheakdlvkgTDILDIWFDSGSTWSAVLGKDKI------ 582
Cdd:cd00668 195 ---------------------------------------------------EDVFDVWFDSGIGPLGSLGYPEEkewfkd 223
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281366294 583 ---ADLYLEGYDQFTGWFQSSLLMSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVAS 658
Cdd:cd00668 224 sypADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTS 302
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
72-814 |
2.44e-33 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 138.73 E-value: 2.44e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 72 KGKPTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKA--TSTAPGQsaqeirqksr 149
Cdd:TIGR00396 26 SSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGLPAENAAikRGIHPAK---------- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 150 aFAWEAIKSQKEEFSSWGILANWQKDniYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRTALAEAELEYDA- 228
Cdd:TIGR00396 96 -WTYENIANMKKQLQALGFSYDWDRE--IATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGTVLANEQVDSDGr 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 229 ----------------------------------------------NHISPSVYVRFalnpsSFDVKDKQIYALVWTTTP 262
Cdd:TIGR00396 173 swrgdtpvekkelkqwflkitayaeellndleeldhwpesvkemqrNWIGKSEGVEI-----TFKIADHDEKITVFTTRP 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 263 WTLpsnQAICYNA-SLEYVIVRLSDRNQDEL--YLMASALMADFEANTQLKCEivqhlSGELLsKLSYNHPIDKEQsnLP 339
Cdd:TIGR00396 248 DTI---FGVTYLAlAPEHPLVEKAAENNPKVaaFIKKILNKTVAERTKATKEK-----KGVDT-GIKAIHPLTGEK--IP 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 340 FFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKCFVNEEGtytkeapdflrgksvldqGNSLVLDRIAEDVVHSS 419
Cdd:TIGR00396 317 IWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAE------------------KDLSLTAAYTEDGVLVN 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 420 KLEHSypidwRTKKPVIIRASEQWFINTEKlktpaadaleqveiypranaeaSKKALLTQLQKrpyWCISRQRAWGVPIP 499
Cdd:TIGR00396 379 SGEFN-----GLNSSEARNAIIDMLEKEGK----------------------GKRKVNYRLRD---WGFSRQRYWGEPIP 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 500 VLYSRESGKV-VLNSALIEHLCNL--LRKEGSIDFW----WVKSVEELVPEHLLRElhheakdlvkgTDILDIWfdSGST 572
Cdd:TIGR00396 429 IIHCEDGGVVpVPEEDLPVILPEDvvYDGDGGSPLSripeWVNVTCPSCGKPALRE-----------TDTMDTF--AGSS 495
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 573 W-----------SAVLGKDKIA-----DLYLEG---------YDQFTGWFQSSLLMsIAAREcaPYKALF----VHGFTV 623
Cdd:TIGR00396 496 WyylryldpkntDGPFDKEKAEywlpvDLYIGGiehailhllYARFFHKFLRDIGY-VNTKE--PFKKLInqgmVLGFYY 572
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 624 DEKG---------------------------YKMSKSLGNVISPKQITKKYGTDALRWWVASHGTQHMSITVSDKllqqa 676
Cdd:TIGR00396 573 PPNGkvpadvlterdekgkdkaggelvyvgyEKMSKSKGNGIDPQEIVESYGADALRLFIMFMGPIAASLEWNES----- 647
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 677 aenlcKIRGTMRYLKGV--IGEKQSGEKLIRTSDKSYLN---RYLLSQLVEFESEV-EKLYQAYEYNRVVACVQNFIaNQ 750
Cdd:TIGR00396 648 -----GLEGARRFLDRVwnLVYEITGELDAASLTVTALEeaqKELRRDVHKFLKKVtEDLEKRESFNTAISAMMELL-NK 721
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281366294 751 VSAVyvhlIKDRLYCgddhellairqtltHCYQQLCKSLWPIVPFLVEESWSYYDTTGGAFHEQ 814
Cdd:TIGR00396 722 LYKA----KKEALML--------------EYLKGFVTVLSPFAPHLAEELWEKLGSEPFIIDNA 767
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
76-214 |
4.03e-31 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 124.45 E-value: 4.03e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 76 TFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKATSTAPGQSAQEI----RQKSRAF 151
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIWieefREDPKEF 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281366294 152 AWEAIKSQKEEFSSWGILANWQKDniYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPS 214
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDE--YITTEPEYSKAVELIFSRLYEKGLIYRGTHPVRITEQ 141
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
75-223 |
1.36e-27 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 115.81 E-value: 1.36e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 75 PTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKATST--APGQSAQEI-RQKSRAF 151
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKlgIEGKTRHDLgREEFLEK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281366294 152 AW----EAIKSQKEEFSSWGILANWqkDNIYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRTALAEAE 223
Cdd:cd00817 81 CWewkeESGGKIREQLKRLGASVDW--SREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIE 154
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
180-842 |
3.08e-19 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 93.39 E-value: 3.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 180 TFQpEFIVNQlemFYNLYEKGLVYRDLKPVYWSPSSRTAL--------AEAE-LEYDAnhispsvyVRFAlnpssfdvKD 250
Cdd:PRK12300 108 EYS-KFIEWQ---FRKLKEKGLIVKGSHPVRYCPNDNNPVgdhdlldgEEPEiVEYTL--------IKFE--------ES 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 251 KQIYALVWTTTPWTLPSNQAICYNASLEYVIVRLSDRNqdelYLMaSALMADFEANTQLKCEIVQHLSGELLSKLSYNHP 330
Cdd:PRK12300 168 EDLILPAATLRPETIFGVTNLWVNPDATYVKAEVDGEK----WIV-SKEAAEKLSFQDRDVEIIEEIKGSELIGKKVKNP 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 331 IDKEQsnLPFFDASHVQDSKGTGLVHTAPAHGPEDF-----------------LVSLTQ-----KIPVKCFVNEEGT--- 385
Cdd:PRK12300 243 VTGKE--VPILPADFVDPDNGTGVVMSVPAHAPYDYvalrdlkknkelldviePIPLIEvegygEFPAKEVVEKLGIksq 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 386 -------YTKE--------------APDFlRGKSVLDqgnslVLDRIAEDVVHSSKLEHSYPIdwrTKKPVIIRA----- 439
Cdd:PRK12300 321 edpeleeATKEvyraefhkgvlkenTGEY-AGKPVRE-----AREKITKDLIEKGIADIMYEF---SNRPVYCRCgtecv 391
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 440 ----SEQWFIN--TEKLKTPAADALEQVEIYP---RANAEAskkaLLTQLQKRPywCiSRQRAWGVPIPvlYSRESgkvv 510
Cdd:PRK12300 392 vkvvKDQWFIDysDPEWKELAHKALDNMEIIPeeyRKEFEN----TIDWLKDRA--C-ARRRGLGTRLP--WDEEW---- 458
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 511 lnsaLIEHL------------CNLLRKEG------SIDFW-WVK----SVEEL-----VPEHLLRELHHEakdlvkgtdi 562
Cdd:PRK12300 459 ----IIESLsdstiymayytiAHKIREYGikpeqlTPEFFdYVFlgkgDPEEVskktgIPKEILEEMREE---------- 524
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 563 LDIWF--DSGSTwsavlGKDKIADlYLegydqftgwfqSSLLMSIAA---RECAPyKALFVHGFTVDEkGYKMSKSLGNV 637
Cdd:PRK12300 525 FLYWYpvDWRHS-----GKDLIPN-HL-----------TFFIFNHVAifpEEKWP-RGIVVNGFVLLE-GKKMSKSKGNV 585
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 638 ISPKQITKKYGTDALRWWVASHGTQHMSITVSDKLLQQAAENLCKIRGTMRYLKGVIGEKQSGeklirtsdksYLNRYLL 717
Cdd:PRK12300 586 IPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQLERFYELAKELIEIGGEEELR----------FIDKWLL 655
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 718 SQLVEFESEVEKLYQAYEYNRVVacvqnfianqVSAVY--VHLIKDRLYCGDDHELLAIRQTLthcyQQLCKSLWPIVPF 795
Cdd:PRK12300 656 SRLNRIIKETTEAMESFQTRDAV----------QEAFYelLNDLRWYLRRVGEANNKVLREVL----EIWIRLLAPFTPH 721
|
730 740 750 760
....*....|....*....|....*....|....*....|....*..
gi 281366294 796 LVEESWSYYDTTGGAFHEQIVQTNPEWQDTKATEVINAafdVKRLIN 842
Cdd:PRK12300 722 LAEELWHKLGGEGFVSLEKWPEPDESKIDEEAELAEEY---VKRLIE 765
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
713-843 |
2.59e-18 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 82.45 E-value: 2.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 713 NRYLLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYCGDDHELlaIRQTLTHCYQQLCKSLWPI 792
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSR--AQTTLYEVLETLLRLLAPF 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 281366294 793 VPFLVEESWSYydttgGAFHEQIVQTNPEWQDTKATEVINAAFDVKRLINQ 843
Cdd:pfam08264 79 MPFITEELWQK-----ESIHLAPWPEDAELEEAELEEAFELRQEIVQAIRK 124
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
74-653 |
2.03e-17 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 87.57 E-value: 2.03e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 74 KPTFVLHDGPPYANGQ-LHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKATSTapGQSAQEIRQKSrafa 152
Cdd:PLN02563 109 KPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAEQYAIET--GTHPKITTLKN---- 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 153 weaIKSQKEEFSSWGILANWQKDniYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRTALAEAEL-------- 224
Cdd:PLN02563 183 ---IARFRSQLKSLGFSYDWDRE--ISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVvdglserg 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 225 -------------------------------------EYDANHISPSVYVRFALNPSSFDVKDKQIYALVWTTTPWTL-- 265
Cdd:PLN02563 258 ghpvirkpmrqwmlkitayadrlledlddldwpesikEMQRNWIGRSEGAELDFSVLDGEGKERDEKITVYTTRPDTLfg 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 266 -------PSNQAICYNASLEyvivrlsDRNQDELYLMASALMADFEaNTQLKCEIVQHLSGellsklSY-NHPIDKEQsn 337
Cdd:PLN02563 338 atylvvaPEHPLLSSLTTAE-------QKEAVEEYVDAASRKSDLE-RTELQKEKTGVFTG------SYaINPATGEA-- 401
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 338 LPFFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKCFV--NEEGTYTKEAPDFLRGKSVldqgNSlvldriaedv 415
Cdd:PLN02563 402 IPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVkpADGNEDDAEKAYTGEGVIV----NS---------- 467
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 416 vhssklehsypidwrtkkpviirASEQWFINTEKLKTPAADALEQVEiyprANAEASKKALLtqlqKRPYWCISRQRAWG 495
Cdd:PLN02563 468 -----------------------SSSGLDINGLSSKEAAKKVIEWLE----ETGNGKKKVNY----KLRDWLFARQRYWG 516
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 496 VPIPVLYSRESGKVV--LNSALIEHLCNL------------LRKEGSidfwWVKSVEELVPEHLLRElhheakdlvkgTD 561
Cdd:PLN02563 517 EPIPVVFLEDSGEPVpvPESDLPLTLPELddftptgtgeppLAKAVS----WVNTVDPSSGKPARRE-----------TN 581
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 562 ILDIWfdSGSTW-----------SAVLGKDK-----IADLYLEG------------------YD---------------- 591
Cdd:PLN02563 582 TMPQW--AGSCWyylrfmdpknsNALVDKEKekywmPVDLYVGGaehavlhllyarfwhkvlYDigvvstkepfqclvnq 659
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 592 -------QFTGWFQS-----SLLMSIAARECAPYK----------ALFVHGFT----VDEKGYKMSKSLGNVISPKQITK 645
Cdd:PLN02563 660 gmilgevEYTAFKDSdgeyvSADTADRLGELQQEKipeekviksgDSFVLKDDpsirLIARAHKMSKSRGNVVNPDDVVS 739
|
....*...
gi 281366294 646 KYGTDALR 653
Cdd:PLN02563 740 EYGADSLR 747
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
431-802 |
4.88e-17 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 85.55 E-value: 4.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 431 TKKPVIIRASEQWFINTEKLktpaADALEQ-VEIYPRANAEASKKAL--LTQ-LQKrpyWCISRQRAWGVPIP-----VL 501
Cdd:COG0143 174 SGAPPELREEEHYFFRLSKY----QDRLLEwIEENPDIQPEVRNEVLswLKEgLQD---LSISRDFDWGIPVPgdpgkVF 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 502 YsresgkV----VLN--SALIEhLCNLLRKEGSIDFWWVKSVEELVpeHLLrelhheakdlvkgtdildiwfdsgstwsa 575
Cdd:COG0143 247 Y------VwfdaLIGyiSATKG-YADDRGLPEDFEKYWPAPDTELV--HFI----------------------------- 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 576 vlGKDKIadlylegydQFTGWFQSSLLMSIaarECAPYKALFVHGF-TVDekGYKMSKSLGNVISPKQITKKYGTDALRW 654
Cdd:COG0143 289 --GKDII---------RFHAIIWPAMLMAA---GLPLPKKVFAHGFlTVE--GEKMSKSRGNVIDPDDLLDRYGPDALRY 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 655 WVASHG--TQHMSITVSDklLQQA--AE------NLCK--IRGTMRYLKGVIGEKQSGEKLirtsDKSylnryLLSQLVE 722
Cdd:COG0143 353 YLLREVpfGQDGDFSWED--FVARvnSDlandlgNLASrtLSMIHKYFDGKVPEPGELTEA----DEE-----LLAEAEA 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 723 FESEVEKLYQAYEYNRVVACVQNFI--ANQvsavYV------HLIKDrlycgDDHELLAirQTLTHCYQ---QLCKSLWP 791
Cdd:COG0143 422 ALEEVAEAMEAFEFRKALEEIMALAraANK----YIdetapwKLAKD-----EDPERLA--TVLYTLLEalrILAILLKP 490
|
410
....*....|.
gi 281366294 792 IVPFLVEESWS 802
Cdd:COG0143 491 FLPETAEKILE 501
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
712-802 |
1.48e-13 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 68.35 E-value: 1.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 712 LNRYLLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYCGDDHELLAIRQTLTHCYQQLCKSLWP 791
Cdd:cd07962 43 ADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWNDFCDWYLELVKPRLYGEDEEEKKAARATLYYVLETILRLLHP 122
|
90
....*....|.
gi 281366294 792 IVPFLVEESWS 802
Cdd:cd07962 123 FMPFITEELWQ 133
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
84-211 |
5.93e-13 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 70.74 E-value: 5.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 84 PYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIElkatstapgQSAQEIRQKSRAFAWEAIKSQKEEF 163
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAE---------NAAIKIGRDPEDWTEYNIKKMKEQL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 281366294 164 SSWGILANWQKdNIYMTFqPEFIVNQLEMFYNLYEKGLVYRDLKPVYW 211
Cdd:cd00812 80 KRMGFSYDWRR-EFTTCD-PEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
424-660 |
1.84e-12 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 69.20 E-value: 1.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 424 SYPIDWRtkkpviiRASEQWFINT--EKLKTPAADALEQVEIYPRAnaeaskkallTQLQKRPYWCISRQRAWGVPIPVL 501
Cdd:cd00812 120 EAPVNWC-------KLLDQWFLKYseTEWKEKLLKDLEKLDGWPEE----------VRAMQENWIGCSRQRYWGTPIPWT 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 502 YSRES-------GKVVLNSALIEHLCNLLRKEG--SIDFW----WVKSVEELVPEHLLREL-HHEAkdlvkgtdildiwf 567
Cdd:cd00812 183 DTMESlsdstwyYARYTDAHNLEQPYEGDLEFDreEFEYWypvdIYIGGKEHAPNHLLYSRfNHKA-------------- 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 568 dsgstwsavlgkdkiadLYLEGYdQFTGWFqssllmsiaarecapyKALFVHGFTVDEkGYKMSKSLGNVISPKQITKKY 647
Cdd:cd00812 249 -----------------LFDEGL-VTDEPP----------------KGLIVQGMVLLE-GEKMSKSKGNVVTPDEAIKKY 293
|
250
....*....|...
gi 281366294 648 GTDALRWWVASHG 660
Cdd:cd00812 294 GADAARLYILFAA 306
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
436-660 |
3.19e-12 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 68.71 E-value: 3.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 436 IIRASEQWFINTEKLKtpaaDALEQ------VEIYPrANAEASKKALLTQ-LQKrpyWCISRQRA-WGVPIPVlysrESG 507
Cdd:cd00814 133 EWREEEHYFFRLSKFQ----DRLLEwleknpDFIWP-ENARNEVLSWLKEgLKD---LSITRDLFdWGIPVPL----DPG 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 508 KV--VLNSALIEHLC---NLLRKEGSIDFWWVKSVEelvpehllreLHHeakdlvkgtdildiwfdsgstwsaVLGKDKI 582
Cdd:cd00814 201 KViyVWFDALIGYISatgYYNEEWGNSWWWKDGWPE----------LVH------------------------FIGKDII 246
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281366294 583 adlylegydQFTGWFQSSLLMSIaarECAPYKALFVHGFTVDEKGyKMSKSLGNVISPKQITKKYGTDALRWWVASHG 660
Cdd:cd00814 247 ---------RFHAIYWPAMLLGA---GLPLPTRIVAHGYLTVEGK-KMSKSRGNVVDPDDLLERYGADALRYYLLRER 311
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
426-660 |
1.23e-11 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 67.70 E-value: 1.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 426 PIDWRTKKPVIIRASEQWFINTEKLKTPAADALEQVEIYPRANAEASKKALLTQ-LQKrpyWCISRQRAWGVPIP----- 499
Cdd:pfam09334 167 PKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEENNPEWPENVKNMVLEWLKEgLKD---RAISRDLDWGIPVPgaegk 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 500 VLYsresgkvVLNSALIEHLC---NLLRKEGSIDFWWVKSVEElvpehllrELHHeakdlvkgtdildiwfdsgstwsaV 576
Cdd:pfam09334 244 VFY-------VWLDAPIGYISatkELSGNEEKWKEWWPNDPDT--------ELVH------------------------F 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 577 LGKDKIadlylegydQFTGWFQSSLLMsiAARECAPyKALFVHGF-TVDekGYKMSKSLGNVISPKQITKKYGTDALRWW 655
Cdd:pfam09334 285 IGKDII---------YFHTIFWPAMLL--GAGYRLP-TTVFAHGYlTYE--GGKMSKSRGNVVWPSEALDRFPPDALRYY 350
|
....*
gi 281366294 656 VASHG 660
Cdd:pfam09334 351 LARNR 355
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
84-654 |
1.45e-11 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 68.54 E-value: 1.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 84 PYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYiP-GWDCHGLPIELKA--TSTAPgqsaqeirqksRAFAWEAIKSQK 160
Cdd:COG0495 42 PYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVLH-PmGWDAFGLPAENAAikNGVHP-----------AEWTYENIANMR 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 161 EEFSSWGILANWQKDNIymTFQPEFIV-NQLeMFYNLYEKGLVYRDLKPVYWSPSSRTALA-E----------------- 221
Cdd:COG0495 110 RQLKRLGLSYDWSREIA--TCDPEYYKwTQW-IFLQLYEKGLAYRKEAPVNWCPVDQTVLAnEqvidgrcwrcgapvekk 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 222 ------------A-ELEYD---------------ANHI--SPSVYVRFALNPSsfdvkDKQIYalVWTTTPWTLpsnqai 271
Cdd:COG0495 187 elpqwflkitdyAdELLDDldkldgwpekvktmqRNWIgrSEGAEVDFPVEGS-----DEKIT--VFTTRPDTL------ 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 272 cYNASleYVIV--------RL-SDRNQDEL--YLMASALMADFEAN----------TQLKCEivqhlsgellsklsynHP 330
Cdd:COG0495 254 -FGAT--FMVLapehplvkELaTPEQNAAVaaFIEEAKKKSEIERTsetkektgvfTGLYAI----------------NP 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 331 IDKEQsnLPFFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKC-FVNEEGTYTKEAPDFLRGKSVLdqgnslvld 409
Cdd:COG0495 315 LTGEK--IPIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQvIAPEDGDDPDILEEAYTGDGVL--------- 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 410 riaedvVHSSKLehsypiDWrtkkpviiraseqwfINTEKLKTPAADALEQVEIypranaeASKKallTQlqkrpY---- 485
Cdd:COG0495 384 ------INSGEF------DG---------------LDSEEAKEAIIEWLEEKGL-------GKRK---VN-----Yrlrd 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 486 WCISRQRAWGVPIPVLYSrESGKVVLNSAliEHL-------CNLLRKEGS----IDFWwvKSVEelVPEH---LLRElhh 551
Cdd:COG0495 422 WLISRQRYWGEPIPIIHC-EDCGVVPVPE--DQLpvelpedVDFDPTGGSplarAPEW--VNVT--CPKCggpARRE--- 491
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 552 eakdlvkgTDILDIWFDSgStW-----------SAVLGKDKIA-----DLYLEG---------YDQF-------TGWfqs 599
Cdd:COG0495 492 --------TDTMDTFVDS-S-WyylrytdphndEAPFDPEAANywlpvDQYIGGiehailhllYARFftkvlrdLGL--- 558
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281366294 600 sllmsIAAREcaPYKALFVHG--FTVDEKGY------KMSKSLGNVISPKQITKKYGTDALRW 654
Cdd:COG0495 559 -----VSFDE--PFKRLLTQGmvLEVGKDGVviggieKMSKSKGNVVDPDEIIEKYGADTLRL 614
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
614-658 |
1.28e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 64.90 E-value: 1.28e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 281366294 614 KALFVHGF-TVDekGYKMSKSLGNVISPKQITKKYGTDALRWWVAS 658
Cdd:PRK11893 285 KRVFAHGFlTLD--GEKMSKSLGNVIDPFDLVDEYGVDAVRYFLLR 328
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
84-658 |
2.21e-10 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 64.32 E-value: 2.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 84 PYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKATSTapGQSAQEIrqksrafaweaIKSQKEEF 163
Cdd:TIGR00398 8 PYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQE--GLTPKEL-----------VDKYHEEF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 164 SS-WGILaNWQKDNIYMTFQPEFIVNQLEMFYNLYEKGLVYrdlkpvywspssrtaLAEAELEYdanhispsvyvrfaln 242
Cdd:TIGR00398 75 KDdWKWL-NISFDRFIRTTDEEHKEIVQKIFQKLKENGYIY---------------EKEIKQLY---------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 243 pssfDVKDKQIYAlvwtttpwtlpsnqaicynasleyvivrlsDRNQDElylmasalmadfeantqlkceivqhlsgell 322
Cdd:TIGR00398 123 ----CPECEMFLP------------------------------DRYVEG------------------------------- 137
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 323 sklsynhpidkeqsnlpffdashvqdskgtglvhTAPAHGPEDFLvsltqkipvkCFVNEEGTYTKEAPDFLRGKSVLDq 402
Cdd:TIGR00398 138 ----------------------------------TCPKCGSEDAR----------GDHCEVCGRHLEPTELINPRCKIC- 172
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 403 gnslvldriaedvvhssklehsypidwrtKKPVIIRASEQWFINTEKLKTPAADALEQvEIYPRANAEASKKALLTQLQK 482
Cdd:TIGR00398 173 -----------------------------GAKPELRDSEHYFFRLSAFEKELEEWIRK-NPESGSPASNVKNKAQNWLKG 222
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 483 R-PYWCISRQRA-WGVPIPvlysRESGKV--VLNSALIEHLCNLLRKEG-SIDF--WWVKSVEelvpehllRELHHeakd 555
Cdd:TIGR00398 223 GlKDLAITRDLVyWGIPVP----NDPNKVvyVWFDALIGYISSLGILSGdTEDWkkWWNNDED--------AELIH---- 286
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 556 lvkgtdildiwfdsgstwsaVLGKDKIadlylegydQFTGWFQSSLLMsiaARECAPYKALFVHGFTVDEkGYKMSKSLG 635
Cdd:TIGR00398 287 --------------------FIGKDIV---------RFHTIYWPAMLM---GLGLPLPTQVFSHGYLTVE-GGKMSKSLG 333
|
570 580
....*....|....*....|...
gi 281366294 636 NVISPKQITKKYGTDALRWWVAS 658
Cdd:TIGR00398 334 NVVDPSDLLARFGADILRYYLLK 356
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
612-653 |
2.76e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 64.05 E-value: 2.76e-10
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 281366294 612 PYKALFVHG-FTVdeKGYKMSKSLGNVISPKQITKKYGTDALR 653
Cdd:PRK12267 283 LPKKVFAHGwWLM--KDGKMSKSKGNVVDPEELVDRYGLDALR 323
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
618-704 |
6.30e-10 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 62.43 E-value: 6.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 618 VH-GF-TVDEKgyKMSKSLGNVISPKQITKKYGTDALRWWVAShgTQHMS-ITVSDKLLQQAAENLCKIRGTMRYLKGVI 694
Cdd:COG0215 254 MHnGFlTVNGE--KMSKSLGNFFTVRDLLKKYDPEVLRFFLLS--AHYRSpLDFSEEALEEAEKALERLYNALRRLEEAL 329
|
90
....*....|
gi 281366294 695 GEKQSGEKLI 704
Cdd:COG0215 330 GAADSSAEEI 339
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
84-221 |
1.11e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 61.01 E-value: 1.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 84 PYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKATSTapGQSAQEIRQK-SRAFaweaiksqKEE 162
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEE--GVTPQELCDKyHEIF--------KDL 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 281366294 163 FSSWGIlanwQKDNIYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRTALAE 221
Cdd:cd00814 79 FKWLNI----SFDYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLPE 133
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
84-204 |
1.78e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 61.71 E-value: 1.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 84 PYANGQLHMGHAVNKILKDITLR-QRvAHGQRVNYIPGWDCHGLPIELKAtsTAPGQSAQEIRQKSRAfaweaikSQKEE 162
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRyQR-MRGHEVLFVCADDAHGTPIMLKA--EKEGITPEELIARYHA-------EHKRD 80
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 281366294 163 FSSWGIlanwQKDNIYMTFQPEFIVNQLEMFYNLYEKGLVYR 204
Cdd:PRK00133 81 FAGFGI----SFDNYGSTHSEENRELAQEIYLKLKENGYIYE 118
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
605-659 |
2.63e-06 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 49.11 E-value: 2.63e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 281366294 605 IAARECAPYKAL---FVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVASH 659
Cdd:cd00672 147 IAQSEAATGKPFaryWLHTGHLTIDGEKMSKSLGNFITVRDALKKYDPEVLRLALLSS 204
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
565-655 |
1.46e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 48.94 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 565 IWFDSGSTWSAVLGKDKI-------------ADLYLEGYD--QFTGWFQSSLLMSiAARECApyKALFVHGFtVDEKGYK 629
Cdd:PLN02224 291 VWFDALLGYISALTEDNKqqnletavsfgwpASLHLIGKDilRFHAVYWPAMLMS-AGLELP--KMVFGHGF-LTKDGMK 366
|
90 100
....*....|....*....|....*.
gi 281366294 630 MSKSLGNVISPKQITKKYGTDALRWW 655
Cdd:PLN02224 367 MGKSLGNTLEPFELVQKFGPDAVRYF 392
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
696-801 |
2.31e-05 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 46.01 E-value: 2.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 696 EKQSGEKLIRTSDKSYLNRYLLSQLVEFESEVEKLYQAYEYNRVVACVQNFIaNQVSAVYVHLIKDRLY-CGDDHELLAI 774
Cdd:cd07961 32 GFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFI-DELTNWYIRRNRKRFWgEEGDDDKLAA 110
|
90 100
....*....|....*....|....*..
gi 281366294 775 RQTLTHCYQQLCKSLWPIVPFLVEESW 801
Cdd:cd07961 111 YATLYEVLLTLSRLMAPFTPFITEEIY 137
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
605-676 |
3.55e-05 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 46.98 E-value: 3.55e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281366294 605 IAARECA---PYKALFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVASHGTQHMsITVSDKLLQQA 676
Cdd:pfam01406 226 IAQSEAAfdkQLANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLSVHYRSP-LDFSEELLEQA 299
|
|
| LysRS_core_class_I |
cd00674 |
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) ... |
611-666 |
2.32e-04 |
|
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The class I LysRS is found only in archaea and some bacteria and has evolved separately from class II LysRS, as the two do not share structural or sequence similarity.
Pssm-ID: 173900 [Multi-domain] Cd Length: 353 Bit Score: 44.62 E-value: 2.32e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 281366294 611 APYKalFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVASHGTQHMSI 666
Cdd:cd00674 259 PPVP--VMYEFIGLKGGGKMSSSKGNVITPSDWLEVAPPEVLRYLYARRKNPEKHI 312
|
|
| PLN02946 |
PLN02946 |
cysteine-tRNA ligase |
617-699 |
2.58e-04 |
|
cysteine-tRNA ligase
Pssm-ID: 178532 [Multi-domain] Cd Length: 557 Bit Score: 44.92 E-value: 2.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 617 FVH-GF-TVDEKgyKMSKSLGNVISPKQITKKYGTDALRWWVAshGTQHMS-ITVSDKLLQQAAENLCKIRGTMRYLKGV 693
Cdd:PLN02946 311 WIHnGFvTVDSE--KMSKSLGNFFTIRQVIDLYHPLALRLFLL--GTHYRSpINYSDVQLESASERIFYIYQTLHDCEES 386
|
....*.
gi 281366294 694 IGEKQS 699
Cdd:PLN02946 387 LQQHDS 392
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
83-156 |
3.10e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 44.49 E-value: 3.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366294 83 PPYANGQLHMGHAVNKILKDI---TLRQRvahGQRVNYIPGWDCHGLPIELKAtsTAPGQSAQEI-RQKSRAFA--WEAI 156
Cdd:PRK11893 9 IYYPNGKPHIGHAYTTLAADVlarFKRLR---GYDVFFLTGTDEHGQKIQRKA--EEAGISPQELaDRNSAAFKrlWEAL 83
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
611-672 |
2.23e-03 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 41.72 E-value: 2.23e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281366294 611 APYKalFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVA--SHGTQHMSITVSDKL 672
Cdd:PRK00750 264 PPEP--FVYELFLDKKGEKISKSKGNVITIEDWLEYAPPESLRLFMFarPKPAKRLDFDVIPKL 325
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
611-659 |
4.61e-03 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 40.32 E-value: 4.61e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 281366294 611 APYKalFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVASH 659
Cdd:pfam01921 263 PPEG--FPYELILLKGGGKMSSSKGNVITPEDWLEYAPPESLRFLMFRT 309
|
|
| |
