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Conserved domains on  [gi|239835767|ref|NP_620170|]
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developmental pluripotency-associated protein 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dppa2_A pfam14049
Dppa2/4 conserved region in higher vertebrates; Developmental pluripotency associated genes ...
 131-215 2.33e-47

Dppa2/4 conserved region in higher vertebrates; Developmental pluripotency associated genes (Dppa) in lower vertebrates have remained undetected until the discovery of a Dppa homolog in Xenopus laevis, reporting a new domain termed Dppa2/4 conserved region (DCR). In higher vertebrate Dppa proteins the DCR domain is located next to the here-reported domain. The domain is subject to structure determination by the Joint Center of Structural Genomics.


:

Pssm-ID: 433674  Cd Length: 85  Bit Score: 153.45  E-value: 2.33e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239835767  131 RQDMPEMSQETRLQRCSRKRKAVTKRARLQRSYEMNERAEETNTVEVITSAPGAMLASWARIAARAVQPKALNSCSIPVS 210
Cdd:pfam14049   1 KCNIPETSREARLQSCSRKGKMVTKRARPQKSCKMSEREEETNVVEVITSAQEAMLAAWARIAARAGQPKAVNSCSIPAS 80


                  ....*
gi 239835767  211 VEAFL 215
Cdd:pfam14049  81 VEAFL 85
DCR pfam14047
Dppa2/4 conserved region; This domain has been characterized in the finding of a developmental ...
 220-286 5.53e-40

Dppa2/4 conserved region; This domain has been characterized in the finding of a developmental pluripotency associated gene (Dppa) in the lower vertebrate Xenopus laevis. Previous to this discovery, Dppa genes were known only in higher vertebrates. The domain is subject to structure determination by the Joint Center of Structural Genomics.


:

Pssm-ID: 464071  Cd Length: 67  Bit Score: 134.07  E-value: 5.53e-40
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 239835767  220 GVRWCVVHGRLLSADTKGWVRLQFHAGQAWVPTTHRRMISLFLLPACIFPSPGIEDNMLCPDCAKRN 286
Cdd:pfam14047   1 GKRWCVVHGALLPADPEGWVRLQFHGGQWWVPKTPRRMISLFLLPACIFPPPGLEDNMLCPECVKRN 67
SAP super family cl46922
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
99-122 4.04e-03

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


The actual alignment was detected with superfamily member smart00513:

Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 34.38  E-value: 4.04e-03
                           10        20
                   ....*....|....*....|....
gi 239835767    99 TLRDWCQQLGLSTNGKKIEVYLRL 122
Cdd:smart00513   8 ELKDELKKRGLSTSGTKAELVDRL 31
 
Name Accession Description Interval E-value
Dppa2_A pfam14049
Dppa2/4 conserved region in higher vertebrates; Developmental pluripotency associated genes ...
 131-215 2.33e-47

Dppa2/4 conserved region in higher vertebrates; Developmental pluripotency associated genes (Dppa) in lower vertebrates have remained undetected until the discovery of a Dppa homolog in Xenopus laevis, reporting a new domain termed Dppa2/4 conserved region (DCR). In higher vertebrate Dppa proteins the DCR domain is located next to the here-reported domain. The domain is subject to structure determination by the Joint Center of Structural Genomics.


Pssm-ID: 433674  Cd Length: 85  Bit Score: 153.45  E-value: 2.33e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239835767  131 RQDMPEMSQETRLQRCSRKRKAVTKRARLQRSYEMNERAEETNTVEVITSAPGAMLASWARIAARAVQPKALNSCSIPVS 210
Cdd:pfam14049   1 KCNIPETSREARLQSCSRKGKMVTKRARPQKSCKMSEREEETNVVEVITSAQEAMLAAWARIAARAGQPKAVNSCSIPAS 80


                  ....*
gi 239835767  211 VEAFL 215
Cdd:pfam14049  81 VEAFL 85
DCR pfam14047
Dppa2/4 conserved region; This domain has been characterized in the finding of a developmental ...
 220-286 5.53e-40

Dppa2/4 conserved region; This domain has been characterized in the finding of a developmental pluripotency associated gene (Dppa) in the lower vertebrate Xenopus laevis. Previous to this discovery, Dppa genes were known only in higher vertebrates. The domain is subject to structure determination by the Joint Center of Structural Genomics.


Pssm-ID: 464071  Cd Length: 67  Bit Score: 134.07  E-value: 5.53e-40
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 239835767  220 GVRWCVVHGRLLSADTKGWVRLQFHAGQAWVPTTHRRMISLFLLPACIFPSPGIEDNMLCPDCAKRN 286
Cdd:pfam14047   1 GKRWCVVHGALLPADPEGWVRLQFHGGQWWVPKTPRRMISLFLLPACIFPPPGLEDNMLCPECVKRN 67
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
99-122 4.04e-03

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 34.38  E-value: 4.04e-03
                           10        20
                   ....*....|....*....|....
gi 239835767    99 TLRDWCQQLGLSTNGKKIEVYLRL 122
Cdd:smart00513   8 ELKDELKKRGLSTSGTKAELVDRL 31
 
Name Accession Description Interval E-value
Dppa2_A pfam14049
Dppa2/4 conserved region in higher vertebrates; Developmental pluripotency associated genes ...
 131-215 2.33e-47

Dppa2/4 conserved region in higher vertebrates; Developmental pluripotency associated genes (Dppa) in lower vertebrates have remained undetected until the discovery of a Dppa homolog in Xenopus laevis, reporting a new domain termed Dppa2/4 conserved region (DCR). In higher vertebrate Dppa proteins the DCR domain is located next to the here-reported domain. The domain is subject to structure determination by the Joint Center of Structural Genomics.


Pssm-ID: 433674  Cd Length: 85  Bit Score: 153.45  E-value: 2.33e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239835767  131 RQDMPEMSQETRLQRCSRKRKAVTKRARLQRSYEMNERAEETNTVEVITSAPGAMLASWARIAARAVQPKALNSCSIPVS 210
Cdd:pfam14049   1 KCNIPETSREARLQSCSRKGKMVTKRARPQKSCKMSEREEETNVVEVITSAQEAMLAAWARIAARAGQPKAVNSCSIPAS 80


                  ....*
gi 239835767  211 VEAFL 215
Cdd:pfam14049  81 VEAFL 85
DCR pfam14047
Dppa2/4 conserved region; This domain has been characterized in the finding of a developmental ...
 220-286 5.53e-40

Dppa2/4 conserved region; This domain has been characterized in the finding of a developmental pluripotency associated gene (Dppa) in the lower vertebrate Xenopus laevis. Previous to this discovery, Dppa genes were known only in higher vertebrates. The domain is subject to structure determination by the Joint Center of Structural Genomics.


Pssm-ID: 464071  Cd Length: 67  Bit Score: 134.07  E-value: 5.53e-40
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 239835767  220 GVRWCVVHGRLLSADTKGWVRLQFHAGQAWVPTTHRRMISLFLLPACIFPSPGIEDNMLCPDCAKRN 286
Cdd:pfam14047   1 GKRWCVVHGALLPADPEGWVRLQFHGGQWWVPKTPRRMISLFLLPACIFPPPGLEDNMLCPECVKRN 67
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
99-122 4.04e-03

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 34.38  E-value: 4.04e-03
                           10        20
                   ....*....|....*....|....
gi 239835767    99 TLRDWCQQLGLSTNGKKIEVYLRL 122
Cdd:smart00513   8 ELKDELKKRGLSTSGTKAELVDRL 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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