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Conserved domains on  [gi|19924153|ref|NP_612567|]
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toll-like receptor 4 isoform D [Homo sapiens]

Protein Classification

toll-like receptor( domain architecture ID 11471630)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
474-615 3.50e-34

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 126.67  E-value: 3.50e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153    474 YDAFVIYSSQDedWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEI 553
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEI-DEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19924153    554 AQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNtYLEWEDSVLGRhiFWRRLRKAL 615
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN-YLKWPEDEKEQ--FWKKALYAV 137
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
133-406 4.46e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 4.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 133 QHLELVNCKFGQFPT--LKLKSLKRLTFTSNKGGNAFSEV-DLPSLEFLDLSRNGLS-----FKGCcsqsdfgtTSLKYL 204
Cdd:COG4886 139 KELDLSNNQLTDLPEplGNLTNLKSLDLSNNQLTDLPEELgNLTNLKELDLSNNQITdlpepLGNL--------TNLEEL 210

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 205 DLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSvflSLRNLIYLDISHthtrvafngifNGLSSLEVLKmagnsfq 284
Cdd:COG4886 211 DLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELG---NLTNLEELDLSN-----------NQLTDLPPLA------- 269

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 285 enflpdiftELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQEL 364
Cdd:COG4886 270 ---------NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 19924153 365 QHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVER 406
Cdd:COG4886 341 ALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
474-615 3.50e-34

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 126.67  E-value: 3.50e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153    474 YDAFVIYSSQDedWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEI 553
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEI-DEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19924153    554 AQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNtYLEWEDSVLGRhiFWRRLRKAL 615
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN-YLKWPEDEKEQ--FWKKALYAV 137
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 477-616 1.49e-32

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 123.24  E-value: 1.49e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153   477 FVIYSS----QDEDWVRNELVKNLeeGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYE 552
Cdd:pfam01582   1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153   553 IAQTWQfLSSRAGIIFIVLQKVEK-------TLLRQQVELYRLLSRNTYLEWE------------DSVLGRHIFWRRLRK 613
Cdd:pfam01582  78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156


                  ...
gi 19924153   614 ALL 616
Cdd:pfam01582 157 DIS 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
133-406 4.46e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 4.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 133 QHLELVNCKFGQFPT--LKLKSLKRLTFTSNKGGNAFSEV-DLPSLEFLDLSRNGLS-----FKGCcsqsdfgtTSLKYL 204
Cdd:COG4886 139 KELDLSNNQLTDLPEplGNLTNLKSLDLSNNQLTDLPEELgNLTNLKELDLSNNQITdlpepLGNL--------TNLEEL 210

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 205 DLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSvflSLRNLIYLDISHthtrvafngifNGLSSLEVLKmagnsfq 284
Cdd:COG4886 211 DLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELG---NLTNLEELDLSN-----------NQLTDLPPLA------- 269

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 285 enflpdiftELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQEL 364
Cdd:COG4886 270 ---------NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 19924153 365 QHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVER 406
Cdd:COG4886 341 ALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 199-361 1.28e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.73  E-value: 1.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 199 TSLKYLDLsFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSvflSLRNLIYLDISHTHTRVAFNgiFNGLSSLEVLKM 278
Cdd:cd21340  24 KNLKVLYL-YDNKITKIENLEFLTNLTHLYLQNNQIEKIENLE---NLVNLKKLYLGGNRISVVEG--LENLTNLEELHI 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 279 AGNSFQEN----FLPD-IFTELRNLTFLDLSQCQLEQLSPtaFNSLSSLQVLNMSHNNFFSLD--TFPYKCLNSLQVLDY 351
Cdd:cd21340  98 ENQRLPPGekltFDPRsLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDL 175

                       170
                ....*....|
gi 19924153 352 SLNHIMTSKK 361
Cdd:cd21340 176 TGNPVCKKPK 185
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 171-332 4.35e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 4.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  171 DLPSLEFLDLSRNglSFKGCCSQSdFGTTSLKYLDLS---FNGVItmSSNFLGLEQLEHLDFQHSNLKQM--SEFSvflS 245
Cdd:PLN00113 450 DMPSLQMLSLARN--KFFGGLPDS-FGSKRLENLDLSrnqFSGAV--PRKLGSLSELMQLKLSENKLSGEipDELS---S 521

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  246 LRNLIYLDISHThtrvafngifnglsslevlKMAGNsfqenfLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVL 325
Cdd:PLN00113 522 CKKLVSLDLSHN-------------------QLSGQ------IPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQV 576


                 ....*..
gi 19924153  326 NMSHNNF 332
Cdd:PLN00113 577 NISHNHL 583
LRRCT smart00082
Leucine rich repeat C-terminal domain;
379-425 6.72e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.27  E-value: 6.72e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 19924153    379 NDFACTCEHQSFLQWIKDQRQLLvEVERMECATPSDKQGmPVLSLNI 425
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ-DPVDLRCASPSSLRG-PLLELLH 45
LRR_8 pfam13855
Leucine rich repeat;
271-332 6.33e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 6.33e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19924153   271 SSLEVLKMAGNSFQeNFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNF 332
Cdd:pfam13855   1 PNLRSLDLSNNRLT-SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
474-615 3.50e-34

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 126.67  E-value: 3.50e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153    474 YDAFVIYSSQDedWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEI 553
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEI-DEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19924153    554 AQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNtYLEWEDSVLGRhiFWRRLRKAL 615
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN-YLKWPEDEKEQ--FWKKALYAV 137
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 477-616 1.49e-32

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 123.24  E-value: 1.49e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153   477 FVIYSS----QDEDWVRNELVKNLeeGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYE 552
Cdd:pfam01582   1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153   553 IAQTWQfLSSRAGIIFIVLQKVEK-------TLLRQQVELYRLLSRNTYLEWE------------DSVLGRHIFWRRLRK 613
Cdd:pfam01582  78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156


                  ...
gi 19924153   614 ALL 616
Cdd:pfam01582 157 DIS 159
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 477-572 4.04e-13

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 66.18  E-value: 4.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153   477 FVIYSSQDEDWVRnELVKNLEE-GVPPFqlcLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAq 555
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAaGYRVW---LDRWDIRPGDDWVEEI-EEAIENSDRVLVVLSPNYLESPWCRAEWEAA- 75

                          90
                  ....*....|....*..
gi 19924153   556 tWQFLSSRAGIIFIVLQ 572
Cdd:pfam13676  76 -LADPEGRKRLIPVRLE 91
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
133-406 4.46e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 4.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 133 QHLELVNCKFGQFPT--LKLKSLKRLTFTSNKGGNAFSEV-DLPSLEFLDLSRNGLS-----FKGCcsqsdfgtTSLKYL 204
Cdd:COG4886 139 KELDLSNNQLTDLPEplGNLTNLKSLDLSNNQLTDLPEELgNLTNLKELDLSNNQITdlpepLGNL--------TNLEEL 210

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 205 DLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSvflSLRNLIYLDISHthtrvafngifNGLSSLEVLKmagnsfq 284
Cdd:COG4886 211 DLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELG---NLTNLEELDLSN-----------NQLTDLPPLA------- 269

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 285 enflpdiftELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQEL 364
Cdd:COG4886 270 ---------NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 19924153 365 QHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVER 406
Cdd:COG4886 341 ALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 199-361 1.28e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.73  E-value: 1.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 199 TSLKYLDLsFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSvflSLRNLIYLDISHTHTRVAFNgiFNGLSSLEVLKM 278
Cdd:cd21340  24 KNLKVLYL-YDNKITKIENLEFLTNLTHLYLQNNQIEKIENLE---NLVNLKKLYLGGNRISVVEG--LENLTNLEELHI 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 279 AGNSFQEN----FLPD-IFTELRNLTFLDLSQCQLEQLSPtaFNSLSSLQVLNMSHNNFFSLD--TFPYKCLNSLQVLDY 351
Cdd:cd21340  98 ENQRLPPGekltFDPRsLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDL 175

                       170
                ....*....|
gi 19924153 352 SLNHIMTSKK 361
Cdd:cd21340 176 TGNPVCKKPK 185
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 171-332 4.35e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 4.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  171 DLPSLEFLDLSRNglSFKGCCSQSdFGTTSLKYLDLS---FNGVItmSSNFLGLEQLEHLDFQHSNLKQM--SEFSvflS 245
Cdd:PLN00113 450 DMPSLQMLSLARN--KFFGGLPDS-FGSKRLENLDLSrnqFSGAV--PRKLGSLSELMQLKLSENKLSGEipDELS---S 521

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  246 LRNLIYLDISHThtrvafngifnglsslevlKMAGNsfqenfLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVL 325
Cdd:PLN00113 522 CKKLVSLDLSHN-------------------QLSGQ------IPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQV 576


                 ....*..
gi 19924153  326 NMSHNNF 332
Cdd:PLN00113 577 NISHNHL 583
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 221-379 2.96e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 2.96e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 221 LEQLEHLDFQHSNLKQMSEFSVFLSLRNLiYL---DISH----------THTRVAFNGI-----FNGLSSLEVLKMAGNS 282
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVL-YLydnKITKienlefltnlTHLYLQNNQIekienLENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 283 FQ--ENflpdiFTELRNLTFLDLSQCQL---EQLS--PTAFNSLS-SLQVLNMSHNNFFSLDtfPYKCLNSLQVLDYSLN 354
Cdd:cd21340  80 ISvvEG-----LENLTNLEELHIENQRLppgEKLTfdPRSLAALSnSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNN 152

                       170       180
                ....*....|....*....|....*..
gi 19924153 355 HI--MTSKKQELQHFPsSLAFLNLTQN 379
Cdd:cd21340 153 QIsdLEELLDLLSSWP-SLRELDLTGN 178
LRRCT smart00082
Leucine rich repeat C-terminal domain;
379-425 6.72e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.27  E-value: 6.72e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 19924153    379 NDFACTCEHQSFLQWIKDQRQLLvEVERMECATPSDKQGmPVLSLNI 425
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ-DPVDLRCASPSSLRG-PLLELLH 45
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 149-356 3.35e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 3.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  149 KLKSLKRLTFTSNK--GGNAFSEVDLPSLEFLDLSRNGLSfkGCCSQSDFGTTSLKYLDLSFNGVI-TMSSNFLGLEQLE 225
Cdd:PLN00113 186 NLTSLEFLTLASNQlvGQIPRELGQMKSLKWIYLGYNNLS--GEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQ 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  226 HLDFQHSNLKQMSEFSVFlSLRNLIYLDISHthtrvafngifNGLSSLevlkmagnsfqenfLPDIFTELRNLTFLDLSQ 305
Cdd:PLN00113 264 YLFLYQNKLSGPIPPSIF-SLQKLISLDLSD-----------NSLSGE--------------IPELVIQLQNLEILHLFS 317

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 19924153  306 CQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHI 356
Cdd:PLN00113 318 NNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL 368
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 172-331 7.05e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 7.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  172 LPSLEFLDLSRNGLSFKgcCSQSDFGTT-SLKYLDLS---FNGVITMSSNFLgleqLEHLDFQHSNL--KQMSEFSVFLS 245
Cdd:PLN00113  92 LPYIQTINLSNNQLSGP--IPDDIFTTSsSLRYLNLSnnnFTGSIPRGSIPN----LETLDLSNNMLsgEIPNDIGSFSS 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  246 LRnliYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENfLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVL 325
Cdd:PLN00113 166 LK---VLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQ-IPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHL 241


                 ....*.
gi 19924153  326 NMSHNN 331
Cdd:PLN00113 242 DLVYNN 247
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 152-349 2.89e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  152 SLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKgccSQSDFGT-TSLKYLDLSFNGVITMSSNFLG-LEQLEHLDF 229
Cdd:PLN00113 119 SLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGE---IPNDIGSfSSLKVLDLGGNVLVGKIPNSLTnLTSLEFLTL 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  230 QH--------SNLKQMSEFS-VFLSLRNL---IYLDI----SHTHTRVAFNGI-------FNGLSSLEVLKMAGNSFQEN 286
Cdd:PLN00113 196 ASnqlvgqipRELGQMKSLKwIYLGYNNLsgeIPYEIggltSLNHLDLVYNNLtgpipssLGNLKNLQYLFLYQNKLSGP 275

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19924153  287 FLPDIFTeLRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVL 349
Cdd:PLN00113 276 IPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVL 337
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 27-256 5.67e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 5.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  27 RLHKLTLRNNfdSLnvmktCIQGLAGLE--VHRLVLGEFRNEGNLEKFDKSAL--EGLCNLT--IEEFRLAYldyylddi 100
Cdd:cd00116  82 GLQELDLSDN--AL-----GPDGCGVLEslLRSSSLQELKLNNNGLGDRGLRLlaKGLKDLPpaLEKLVLGR-------- 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 101 idlfNCLTNVSSFSLVSVTIE----RVKDFSYN----FGWQHLelvnCK-FGQFPTLKLKSLKRLTFTSnKGGNAFSEV- 170
Cdd:cd00116 147 ----NRLEGASCEALAKALRAnrdlKELNLANNgigdAGIRAL----AEgLKANCNLEVLDLNNNGLTD-EGASALAETl 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 171 -DLPSLEFLDLSRNGLSFKGC---CSQSDFGTTSLKYLDLSFN-----GVITMSSNFLGLEQLEHLDFQHSNLKQMSEFS 241
Cdd:cd00116 218 aSLKSLEVLNLGDNNLTDAGAaalASALLSPNISLLTLSLSCNditddGAKDLAEVLAEKESLLELDLRGNKFGEEGAQL 297

                       250
                ....*....|....*....
gi 19924153 242 VFLSL----RNLIYLDISH 256
Cdd:cd00116 298 LAESLlepgNELESLWVKD 316
LRR_8 pfam13855
Leucine rich repeat;
271-332 6.33e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 6.33e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19924153   271 SSLEVLKMAGNSFQeNFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNF 332
Cdd:pfam13855   1 PNLRSLDLSNNRLT-SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 172-381 1.85e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 1.85e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 172 LPSLEFLDLSRNGLSFKGCCSQSDF-GTTSLKYLDLSFNGvitmssnflgleqlehLDFQHSNLKQMSEFSVFLSLRNLI 250
Cdd:cd00116  80 GCGLQELDLSDNALGPDGCGVLESLlRSSSLQELKLNNNG----------------LGDRGLRLLAKGLKDLPPALEKLV 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 251 --YLDISHTHTRvAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELR---NLTFLDLSQCQLE-----QLSPTaFNSLS 320
Cdd:cd00116 144 lgRNRLEGASCE-ALAKALRANRDLKELNLANNGIGDAGIRALAEGLKancNLEVLDLNNNGLTdegasALAET-LASLK 221

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 321 SLQVLNMSHNNFFS-----LDTFPYKCLNSLQVLDYSLNHIMT----SKKQELQHFPsSLAFLNLTQNDF 381
Cdd:cd00116 222 SLEVLNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDITDdgakDLAEVLAEKE-SLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
199-258 2.71e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 2.71e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19924153   199 TSLKYLDLSFNGVITMS-SNFLGLEQLEHLDFQHSNLKQMSEfSVFLSLRNLIYLDISHTH 258
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNR 60
PLN03150 PLN03150
hypothetical protein; Provisional
 287-383 4.56e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 4.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  287 FLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQH 366
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGG 512

                         90
                 ....*....|....*..
gi 19924153  367 FPSSLAFLNLTQNDFAC 383
Cdd:PLN03150 513 RLLHRASFNFTDNAGLC 529
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 271-427 8.36e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 8.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  271 SSLEVLKMAGNSFQENfLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFS--LDTFPYKclnSLQV 348
Cdd:PLN00113 404 RSLRRVRLQDNSFSGE-LPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGglPDSFGSK---RLEN 479

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  349 LDYSLNHIMTSKKQELQHFPsSLAFLNLTQNDFacTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLS-LNITC 427
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLS-ELMQLKLSENKL--SGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSqLDLSQ 556
LRR_8 pfam13855
Leucine rich repeat;
320-381 1.71e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.71e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19924153   320 SSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPsSLAFLNLTQNDF 381
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 297-334 2.01e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 2.01e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 19924153   297 NLTFLDLSQCQLEQLSPtaFNSLSSLQVLNMSHNNFFS 334
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKIT 37
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
209-381 2.29e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 2.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 209 NGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFL 288
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153 289 -PDIFTELRNLTFLDLSQC-------QLEQLS---------PTAFNSLSSLQVLNMSHNNFFSLDTfPYKCLNSLQVLDY 351
Cdd:COG4886  88 gLTDLGDLTNLTELDLSGNeelsnltNLESLDlsgnqltdlPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDL 166

                       170       180       190
                ....*....|....*....|....*....|
gi 19924153 352 SLNHImTSKKQELQHFPsSLAFLNLTQNDF 381
Cdd:COG4886 167 SNNQL-TDLPEELGNLT-NLKELDLSNNQI 194
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 268-379 3.14e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 3.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924153  268 NGLSSLEVLKMAGNSFQENFLPDIFtELRNLTFLDLSQCQLE-QLSPTAFNSLSSLQVLNMSHNNFFSldTFPYKCLNSL 346
Cdd:PLN00113  66 NNSSRVVSIDLSGKNISGKISSAIF-RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG--SIPRGSIPNL 142

                         90       100       110
                 ....*....|....*....|....*....|...
gi 19924153  347 QVLDYSLNHIMTSKKQELQHFpSSLAFLNLTQN 379
Cdd:PLN00113 143 ETLDLSNNMLSGEIPNDIGSF-SSLKVLDLGGN 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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