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Conserved domains on  [gi|20270245|ref|NP_612474|]
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zinc finger protein GLI4 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
181-343 2.71e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 2.71e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270245 181 KPHRCEACGKSFKYNSLLLKHQR--IHTGE--KPYACHE--CGKRFrGWSGFI-QHHRIHTGEKPYEC--GQCGRAFSHS 251
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLF-SRNDALkRHILLHTSISPAKEklLNSSSKFSPL 366

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270245 252 SH------FTQHLRIHNGEKPYKCG-ECGQAFSQSSNLVRHQRLHTGEKPYAC--SQCGKAFIWSSVLIEHQRIHTGEKP 322
Cdd:COG5048 367 LNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446

                       170       180
                ....*....|....*....|.
gi 20270245 323 YECSDCGKaFRGRSHFFRHLR 343
Cdd:COG5048 447 LLCSILKS-FRRDLDLSNHGK 466
PRK07003 super family cl35530
DNA polymerase III subunit gamma/tau;
74-182 2.50e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07003:

Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.38  E-value: 2.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270245   74 PDSEPKPEQAPRSPGSQAPDEGAGGALRSL--LRSLPRRARCSAGFGPESSAeRPAGQPPGAVPCAQPRGAWRVTLVQQA 151
Cdd:PRK07003 524 AAAPPAPEARPPTPAAAAPAARAGGAAAALdvLRNAGMRVSSDRGARAAAAA-KPAAAPAAAPKPAAPRVAVQVPTPRAR 602

                         90       100       110
                 ....*....|....*....|....*....|..
gi 20270245  152 AAGPEGAPERAAelgvnfgRSRQGS-ARGAKP 182
Cdd:PRK07003 603 AATGDAPPNGAA-------RAEQAAeSRGAPP 627
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-360 3.09e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.09e-04
                          10        20
                  ....*....|....*....|....
gi 20270245   337 HFFRHLRTHTGEKPFACGACGKAF 360
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
181-343 2.71e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 2.71e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270245 181 KPHRCEACGKSFKYNSLLLKHQR--IHTGE--KPYACHE--CGKRFrGWSGFI-QHHRIHTGEKPYEC--GQCGRAFSHS 251
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLF-SRNDALkRHILLHTSISPAKEklLNSSSKFSPL 366

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270245 252 SH------FTQHLRIHNGEKPYKCG-ECGQAFSQSSNLVRHQRLHTGEKPYAC--SQCGKAFIWSSVLIEHQRIHTGEKP 322
Cdd:COG5048 367 LNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446

                       170       180
                ....*....|....*....|.
gi 20270245 323 YECSDCGKaFRGRSHFFRHLR 343
Cdd:COG5048 447 LLCSILKS-FRRDLDLSNHGK 466
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
74-182 2.50e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.38  E-value: 2.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270245   74 PDSEPKPEQAPRSPGSQAPDEGAGGALRSL--LRSLPRRARCSAGFGPESSAeRPAGQPPGAVPCAQPRGAWRVTLVQQA 151
Cdd:PRK07003 524 AAAPPAPEARPPTPAAAAPAARAGGAAAALdvLRNAGMRVSSDRGARAAAAA-KPAAAPAAAPKPAAPRVAVQVPTPRAR 602

                         90       100       110
                 ....*....|....*....|....*....|..
gi 20270245  152 AAGPEGAPERAAelgvnfgRSRQGS-ARGAKP 182
Cdd:PRK07003 603 AATGDAPPNGAA-------RAEQAAeSRGAPP 627
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-304 3.18e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 3.18e-05
                          10        20
                  ....*....|....*....|....
gi 20270245   281 NLVRHQRLHTGEKPYACSQCGKAF 304
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-360 3.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.09e-04
                          10        20
                  ....*....|....*....|....
gi 20270245   337 HFFRHLRTHTGEKPFACGACGKAF 360
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
181-343 2.71e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 2.71e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270245 181 KPHRCEACGKSFKYNSLLLKHQR--IHTGE--KPYACHE--CGKRFrGWSGFI-QHHRIHTGEKPYEC--GQCGRAFSHS 251
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLF-SRNDALkRHILLHTSISPAKEklLNSSSKFSPL 366

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270245 252 SH------FTQHLRIHNGEKPYKCG-ECGQAFSQSSNLVRHQRLHTGEKPYAC--SQCGKAFIWSSVLIEHQRIHTGEKP 322
Cdd:COG5048 367 LNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446

                       170       180
                ....*....|....*....|.
gi 20270245 323 YECSDCGKaFRGRSHFFRHLR 343
Cdd:COG5048 447 LLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-330 4.25e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 4.25e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20270245 265 KPYKCGECGQAFSQSSNLVRHQRLHTGEKPYACSQ--CGKAFIWSSVLIEHQRIHTGEKPYECSDCGK 330
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-302 1.80e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.80e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20270245 237 KPYECGQCGRAFSHSSHFTQHLRIHNGEKPYKCGECGQA--FSQSSNLVRHQRLHTGEKPYACSQCGK 302
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLP 99
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
74-182 2.50e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.38  E-value: 2.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270245   74 PDSEPKPEQAPRSPGSQAPDEGAGGALRSL--LRSLPRRARCSAGFGPESSAeRPAGQPPGAVPCAQPRGAWRVTLVQQA 151
Cdd:PRK07003 524 AAAPPAPEARPPTPAAAAPAARAGGAAAALdvLRNAGMRVSSDRGARAAAAA-KPAAAPAAAPKPAAPRVAVQVPTPRAR 602

                         90       100       110
                 ....*....|....*....|....*....|..
gi 20270245  152 AAGPEGAPERAAelgvnfgRSRQGS-ARGAKP 182
Cdd:PRK07003 603 AATGDAPPNGAA-------RAEQAAeSRGAPP 627
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-304 3.18e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 3.18e-05
                          10        20
                  ....*....|....*....|....
gi 20270245   281 NLVRHQRLHTGEKPYACSQCGKAF 304
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
198-220 7.32e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 7.32e-05
                          10        20
                  ....*....|....*....|...
gi 20270245   198 LLKHQRIHTGEKPYACHECGKRF 220
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-332 1.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.28e-04
                          10        20
                  ....*....|....*....|...
gi 20270245   310 LIEHQRIHTGEKPYECSDCGKAF 332
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-360 3.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.09e-04
                          10        20
                  ....*....|....*....|....
gi 20270245   337 HFFRHLRTHTGEKPFACGACGKAF 360
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 323-345 3.76e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 3.76e-04
                          10        20
                  ....*....|....*....|...
gi 20270245   323 YECSDCGKAFRGRSHFFRHLRTH 345
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
181-241 3.91e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 3.91e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20270245 181 KPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACH--ECGKRFRGWSGFIQHHRIHTGEKPYEC 241
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 267-289 5.85e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 5.85e-04
                          10        20
                  ....*....|....*....|...
gi 20270245   267 YKCGECGQAFSQSSNLVRHQRLH 289
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
321-373 7.04e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 7.04e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 20270245 321 KPYECSDCGKAFRGRSHFFRHLRTHTGEKPFACGA--CGKAFGQSSQLIQHQRVH 373
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTH 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
228-250 8.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 8.84e-04
                          10        20
                  ....*....|....*....|...
gi 20270245   228 QHHRIHTGEKPYECGQCGRAFSH 250
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-278 1.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 20270245   253 HFTQHLRIHNGEKPYKCGECGQAFSQ 278
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 239-261 1.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|...
gi 20270245   239 YECGQCGRAFSHSSHFTQHLRIH 261
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-351 2.22e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 2.22e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20270245 293 KPYACSQCGKAFIWSSVLIEHQRIHTGEKPYECSD--CGKAFRGRSHFFRHLRTHTGEKPF 351
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD 92
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 183-205 2.29e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.29e-03
                          10        20
                  ....*....|....*....|...
gi 20270245   183 HRCEACGKSFKYNSLLLKHQRIH 205
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
168-353 3.26e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 3.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270245 168 NFGRSRQGSARGAKPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECGKRFRGWSGFIQHHRIHTGEKPYECGQCGRA 247
Cdd:COG5048 156 SSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQL 235

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270245 248 FSHSSHFTQHLRIHNGEKPYKCGECGQAFSQSSNLVRHQRLHTGE-------KPYACSQCGKAFIWSSVLIEHQR--IHT 318
Cdd:COG5048 236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHS 315

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 20270245 319 GE--KPYEC--SDCGKAFRGRSHFFRHLRTHTGEKPFAC 353
Cdd:COG5048 316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE 354
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 91-164 5.59e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 38.93  E-value: 5.59e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20270245   91 APDEGAGGALrSLLRSL---PRRARCSAGFGPESSAERPAGQPPGAVPCAQPRGAWRVTLVQQAAAGPEGAPERAAE 164
Cdd:PRK14951 347 APDEYAALTM-VLLRLLafkPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAP 422
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 211-233 9.77e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 9.77e-03
                          10        20
                  ....*....|....*....|...
gi 20270245   211 YACHECGKRFRGWSGFIQHHRIH 233
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 59-164 9.96e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.04  E-value: 9.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270245   59 LQDVEEVEIGRDTFWPDSEPKPEQAPRSPGSQAPDEGAGGALRSLLRSLPRRARCSAGFGPES-----------SAERPA 127
Cdd:PRK07764 375 LARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPapappspagnaPAGGAP 454

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 20270245  128 GQPPGAVPCAQPRGAWRVTLVQQAAAGPEGAPERAAE 164
Cdd:PRK07764 455 SPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPA 491
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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