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Conserved domains on  [gi|18780285|ref|NP_570118|]
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mucosal addressin cell adhesion molecule 1 isoform b precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adhes-Ig_like pfam09085
Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal ...
 113-222 1.77e-51

Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal cellular adhesion proteins and adopt an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology. They are essential for recruitment of lymphocytes to specific tissues.


:

Pssm-ID: 430399  Cd Length: 110  Bit Score: 164.97  E-value: 1.77e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18780285   113 AFPDQLTVSPAALVPG-DPEVACTAHKVTPVDPNALSFSLLVGGQELEGAQALGPEVQEEEEEPQGdedVLFRVTERWRL 191
Cdd:pfam09085   1 AFPDQLTVSPVTLVPGqDQEVACTAHNVTPADPDTLSFSLLLGDQELEGVQALGPEPEEEPQEGED---LLFRVTQRWLL 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 18780285   192 PPLGTPVPPALYCQATMRLPGLELSHRQAIP 222
Cdd:pfam09085  78 PPLGTPLPPTLHCQATMRLPGLELSHRRAIP 108
IgI_MAdCAM-1 cd20942
Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of ...
 25-112 2.28e-51

Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of the I-set of IgSF domains; The members here include the immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1). MadCAM-1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. MadCAM-1 is expressed primarily on HEV of Peyer's patches and on venules in small intestinal lamina propria, on the marginal sinus of the spleen, and on HEV of embryonic lymph nodes. It is a member of the immunoglobulin superfamily (IgSF), which is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of MAdCAM-1 is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous, but lacks a C" strand.


:

Pssm-ID: 409535  Cd Length: 88  Bit Score: 163.76  E-value: 2.28e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18780285  25 PLQVEPPEPVVAVALGASRQLTCRLACADRGASVQWRGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTFQ 104
Cdd:cd20942   1 PLQVEPPEPVVAVALGASRQLTCRLACADRGASVQWRGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTFQ 80


                ....*...
gi 18780285 105 HTVQLLVY 112
Cdd:cd20942  81 HTVQLLVY 88
 
Name Accession Description Interval E-value
Adhes-Ig_like pfam09085
Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal ...
 113-222 1.77e-51

Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal cellular adhesion proteins and adopt an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology. They are essential for recruitment of lymphocytes to specific tissues.


Pssm-ID: 430399  Cd Length: 110  Bit Score: 164.97  E-value: 1.77e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18780285   113 AFPDQLTVSPAALVPG-DPEVACTAHKVTPVDPNALSFSLLVGGQELEGAQALGPEVQEEEEEPQGdedVLFRVTERWRL 191
Cdd:pfam09085   1 AFPDQLTVSPVTLVPGqDQEVACTAHNVTPADPDTLSFSLLLGDQELEGVQALGPEPEEEPQEGED---LLFRVTQRWLL 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 18780285   192 PPLGTPVPPALYCQATMRLPGLELSHRQAIP 222
Cdd:pfam09085  78 PPLGTPLPPTLHCQATMRLPGLELSHRRAIP 108
IgI_MAdCAM-1 cd20942
Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of ...
 25-112 2.28e-51

Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of the I-set of IgSF domains; The members here include the immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1). MadCAM-1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. MadCAM-1 is expressed primarily on HEV of Peyer's patches and on venules in small intestinal lamina propria, on the marginal sinus of the spleen, and on HEV of embryonic lymph nodes. It is a member of the immunoglobulin superfamily (IgSF), which is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of MAdCAM-1 is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous, but lacks a C" strand.


Pssm-ID: 409535  Cd Length: 88  Bit Score: 163.76  E-value: 2.28e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18780285  25 PLQVEPPEPVVAVALGASRQLTCRLACADRGASVQWRGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTFQ 104
Cdd:cd20942   1 PLQVEPPEPVVAVALGASRQLTCRLACADRGASVQWRGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTFQ 80


                ....*...
gi 18780285 105 HTVQLLVY 112
Cdd:cd20942  81 HTVQLLVY 88
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 30-97 2.80e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 39.10  E-value: 2.80e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18780285    30 PPEPVVAVALGASRQLTCRLACADRGASVQWRGLDTSL------GAVQSDTGRSVLTVRNASLSAAGTRVCVGS 97
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTWSKEGGTLieslkvKHDNGRTTQSSLLISNVTKEDAGTYTCVVN 74
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 33-111 5.50e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.17  E-value: 5.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18780285     33 PVVAVALGASRQLTCRLAcADRGASVQW-RGLDTSLGA-----VQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTFQHT 106
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS-GSPPPEVTWyKQGGKLLAEsgrfsVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSG 80


                   ....*
gi 18780285    107 VQLLV 111
Cdd:smart00410  81 TTLTV 85
 
Name Accession Description Interval E-value
Adhes-Ig_like pfam09085
Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal ...
 113-222 1.77e-51

Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal cellular adhesion proteins and adopt an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology. They are essential for recruitment of lymphocytes to specific tissues.


Pssm-ID: 430399  Cd Length: 110  Bit Score: 164.97  E-value: 1.77e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18780285   113 AFPDQLTVSPAALVPG-DPEVACTAHKVTPVDPNALSFSLLVGGQELEGAQALGPEVQEEEEEPQGdedVLFRVTERWRL 191
Cdd:pfam09085   1 AFPDQLTVSPVTLVPGqDQEVACTAHNVTPADPDTLSFSLLLGDQELEGVQALGPEPEEEPQEGED---LLFRVTQRWLL 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 18780285   192 PPLGTPVPPALYCQATMRLPGLELSHRQAIP 222
Cdd:pfam09085  78 PPLGTPLPPTLHCQATMRLPGLELSHRRAIP 108
IgI_MAdCAM-1 cd20942
Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of ...
 25-112 2.28e-51

Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of the I-set of IgSF domains; The members here include the immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1). MadCAM-1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. MadCAM-1 is expressed primarily on HEV of Peyer's patches and on venules in small intestinal lamina propria, on the marginal sinus of the spleen, and on HEV of embryonic lymph nodes. It is a member of the immunoglobulin superfamily (IgSF), which is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of MAdCAM-1 is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous, but lacks a C" strand.


Pssm-ID: 409535  Cd Length: 88  Bit Score: 163.76  E-value: 2.28e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18780285  25 PLQVEPPEPVVAVALGASRQLTCRLACADRGASVQWRGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTFQ 104
Cdd:cd20942   1 PLQVEPPEPVVAVALGASRQLTCRLACADRGASVQWRGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTFQ 80


                ....*...
gi 18780285 105 HTVQLLVY 112
Cdd:cd20942  81 HTVQLLVY 88
IgI_1_NCAM-1_like cd04977
First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1, and similar ...
 26-112 5.53e-06

First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1. NCAM-1 plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM) and heterophilic (NCAM-nonNCAM) interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves the Ig1, Ig2, and Ig3 domains. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions), through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain. Also included in this group is NCAM-2 (also known as OCAM/mamFas II and RNCAM). NCAM-2 is differentially expressed in the developing and mature olfactory epithelium (OE). This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409366  Cd Length: 95  Bit Score: 44.16  E-value: 5.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18780285  26 LQVEPPEPVVAVALGASRQLTCRLACADRgaSVQWRG--------LDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGS 97
Cdd:cd04977   1 LQVKIIPSYAEISVGESKFFLCKVSGDAK--NINWVSpngekvltKHGNLKVVNHGSVLSSLTIYNANINDAGIYKCVAT 78

                        90
                ....*....|....*.
gi 18780285  98 CG-GRTFQHTVQLLVY 112
Cdd:cd04977  79 NGkGTESEATVKLDII 94
IgI_VCAM-1 cd20943
First immunoglobulin-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1), ...
 31-112 1.32e-04

First immunoglobulin-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1), and similar domains; member of the I-set of IgSF domains; The members here include the first immunoglobulin-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1; also known as Cluster of Differentiation 106 (CD106)) and similar proteins. During the inflammation process, these molecules recruit leukocytes onto the vascular endothelium before extravasation to the injured tissues. The interaction of VCAM-1 binding to the beta1 integrin very late antigen (VLA-4) expressed by lymphocytes and monocytes mediates the adhesion of leucocytes to blood vessel walls, and regulates migration across the endothelium. During metastasis, some circulating cancer cells extravasate to a secondary site by a similar process. VCAM-1 may be involved in organ targeted tumor metastasis and may also act as host receptors for viruses and parasites. VCAM-1 contains seven Ig domains. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of VCAM-1 is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous, but lacks a C" strand.


Pssm-ID: 409536  Cd Length: 89  Bit Score: 39.96  E-value: 1.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18780285  31 PEPVVAVALGASRQLTCRLACADrGASVQWRG-LDTSL-GAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTFQHTVQ 108
Cdd:cd20943   7 PGSRYAAQIGDSVSLTCSTTGCE-SPSFSWRTqIDSPLnGKVRNEGTTSTLTLSPVSFENEHSYLCTVTCESRKLEKGIQ 85


                ....
gi 18780285 109 LLVY 112
Cdd:cd20943  86 VEIY 89
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 30-97 2.80e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 39.10  E-value: 2.80e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18780285    30 PPEPVVAVALGASRQLTCRLACADRGASVQWRGLDTSL------GAVQSDTGRSVLTVRNASLSAAGTRVCVGS 97
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTWSKEGGTLieslkvKHDNGRTTQSSLLISNVTKEDAGTYTCVVN 74
IgI_Perlecan_like cd05754
Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of ...
 28-109 3.45e-04

Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain found in Perlecan. Perlecan is a large multi-domain heparin sulfate proteoglycan, important in tissue development and organogenesis. Perlecan can be represented as 5 major portions; its fourth major portion (domain IV) is a tandem repeat of immunoglobulin-like domains (Ig2-Ig15) which can vary in size due to alternative splicing. Perlecan binds many cellular and extracellular ligands. Its domain IV region has many binding sites. Some of these have been mapped at the level of individual Ig-like domains, including a site restricted to the Ig5 domain for heparin/sulfatide, a site restricted to the Ig3 domain for nidogen-1 and nidogen-2, a site restricted to Ig4-5 for fibronectin, and sites restricted to Ig2 and to Ig13-15 for fibulin-2. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409412  Cd Length: 85  Bit Score: 38.69  E-value: 3.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18780285  28 VEPPEpVVAVALGASRQLTCRLACADRGASVQWRGLDTSLGAVQSDTGrSVLTVRNASLSAAGTRVCVGSCGGRTFQHTV 107
Cdd:cd05754   5 VEEPR-SQEVRPGADVSFICRAKSKSPAYTLVWTRVNGTLPSRAMDFN-GILTIRNVQLSDAGTYVCTGSNMLDTDEATA 82


                ..
gi 18780285 108 QL 109
Cdd:cd05754  83 TL 84
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 33-111 5.50e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.17  E-value: 5.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18780285     33 PVVAVALGASRQLTCRLAcADRGASVQW-RGLDTSLGA-----VQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTFQHT 106
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS-GSPPPEVTWyKQGGKLLAEsgrfsVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSG 80


                   ....*
gi 18780285    107 VQLLV 111
Cdd:smart00410  81 TTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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