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Conserved domains on  [gi|18410455|ref|NP_565072|]
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mitotic-spindle organizing 1B-like protein (DUF3743) [Arabidopsis thaliana]

Protein Classification

mitotic-spindle organizing protein 1( domain architecture ID 10576186)

mitotic-spindle organizing protein 1 (MOZART1) is part of the gamma-tubulin complex and is required for its recruitment to the centrosome

Gene Ontology:  GO:0000931|GO:0090307|GO:0051415
PubMed:  26517054|24570680

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MOZART1 pfam12554
Mitotic-spindle organizing gamma-tubulin ring associated; The name MOZART is derived from ...
 13-55 5.12e-14

Mitotic-spindle organizing gamma-tubulin ring associated; The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, this family does not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. MOZART1 is required for gamma-TuRC recruitment to centrosomes.


:

Pssm-ID: 432631  Cd Length: 43  Bit Score: 59.02  E-value: 5.12e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 18410455   13 LELVFRMSNILETGLDRHTLSVLIALCDIGLNPEALATLVKEL 55
Cdd:pfam12554  1 LDILHEISQLLNTGLDRETLSICIRLCENGVNPEALATVIKEL 43
 
Name Accession Description Interval E-value
MOZART1 pfam12554
Mitotic-spindle organizing gamma-tubulin ring associated; The name MOZART is derived from ...
 13-55 5.12e-14

Mitotic-spindle organizing gamma-tubulin ring associated; The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, this family does not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. MOZART1 is required for gamma-TuRC recruitment to centrosomes.


Pssm-ID: 432631  Cd Length: 43  Bit Score: 59.02  E-value: 5.12e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 18410455   13 LELVFRMSNILETGLDRHTLSVLIALCDIGLNPEALATLVKEL 55
Cdd:pfam12554  1 LDILHEISQLLNTGLDRETLSICIRLCENGVNPEALATVIKEL 43
 
Name Accession Description Interval E-value
MOZART1 pfam12554
Mitotic-spindle organizing gamma-tubulin ring associated; The name MOZART is derived from ...
 13-55 5.12e-14

Mitotic-spindle organizing gamma-tubulin ring associated; The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, this family does not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. MOZART1 is required for gamma-TuRC recruitment to centrosomes.


Pssm-ID: 432631  Cd Length: 43  Bit Score: 59.02  E-value: 5.12e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 18410455   13 LELVFRMSNILETGLDRHTLSVLIALCDIGLNPEALATLVKEL 55
Cdd:pfam12554  1 LDILHEISQLLNTGLDRETLSICIRLCENGVNPEALATVIKEL 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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