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Conserved domains on  [gi|16078855|ref|NP_389675|]
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Spo0A-P phosphatase [Bacillus subtilis subsp. subtilis str. 168]

Protein Classification

aspartyl-phosphate phosphatase Spo0E family protein( domain architecture ID 10559368)

aspartyl-phosphate phosphatase Spo0E specifically dephosphorylates the sporulation transcription factor Spo0A-P and negatively regulates the sporulation initiation pathway in order to control the proper timing of sporulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SpoOE-like pfam09388
Spo0E like sporulation regulatory protein; Spore formation is an extreme response to ...
 6-47 2.62e-11

Spo0E like sporulation regulatory protein; Spore formation is an extreme response to starvation and can also be a component of disease transmission. Sporulation is controlled by an expanded two-component system where starvation signals result in sensor kinase activation and phosphorylation of the master sporulation response regulator Spo0A. Phosphatases such as Spo0E dephosphorylate Spo0A thereby inhibiting sporulation. This is a family of Spo0E-like phosphatases. The structure of a Bacillus anthracis member of this family has revealed an anti-parallel alpha-helical structure.


:

Pssm-ID: 462783  Cd Length: 42  Bit Score: 51.64  E-value: 2.62e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 16078855    6 LLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQYQK 47
Cdd:pfam09388  1 LLKEIEELRKELNELAEKKGLTDPEVVELSQELDELINEYQK 42
 
Name Accession Description Interval E-value
SpoOE-like pfam09388
Spo0E like sporulation regulatory protein; Spore formation is an extreme response to ...
 6-47 2.62e-11

Spo0E like sporulation regulatory protein; Spore formation is an extreme response to starvation and can also be a component of disease transmission. Sporulation is controlled by an expanded two-component system where starvation signals result in sensor kinase activation and phosphorylation of the master sporulation response regulator Spo0A. Phosphatases such as Spo0E dephosphorylate Spo0A thereby inhibiting sporulation. This is a family of Spo0E-like phosphatases. The structure of a Bacillus anthracis member of this family has revealed an anti-parallel alpha-helical structure.


Pssm-ID: 462783  Cd Length: 42  Bit Score: 51.64  E-value: 2.62e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 16078855    6 LLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQYQK 47
Cdd:pfam09388  1 LLKEIEELRKELNELAEKKGLTDPEVVELSQELDELINEYQK 42
Spo0E COG5804
Stage 0 sporulation regulatory phosphatase Spo0E [Cell cycle control, cell division, ...
 1-49 3.08e-10

Stage 0 sporulation regulatory phosphatase Spo0E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444506  Cd Length: 55  Bit Score: 49.45  E-value: 3.08e-10
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....*....
gi 16078855  1 MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQYQKQR 49
Cdd:COG5804  3 MELEELLKKIEELREELNELAEEKGLTDPEVLELSQELDKLLNEYQRLK 51
 
Name Accession Description Interval E-value
SpoOE-like pfam09388
Spo0E like sporulation regulatory protein; Spore formation is an extreme response to ...
 6-47 2.62e-11

Spo0E like sporulation regulatory protein; Spore formation is an extreme response to starvation and can also be a component of disease transmission. Sporulation is controlled by an expanded two-component system where starvation signals result in sensor kinase activation and phosphorylation of the master sporulation response regulator Spo0A. Phosphatases such as Spo0E dephosphorylate Spo0A thereby inhibiting sporulation. This is a family of Spo0E-like phosphatases. The structure of a Bacillus anthracis member of this family has revealed an anti-parallel alpha-helical structure.


Pssm-ID: 462783  Cd Length: 42  Bit Score: 51.64  E-value: 2.62e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 16078855    6 LLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQYQK 47
Cdd:pfam09388  1 LLKEIEELRKELNELAEKKGLTDPEVVELSQELDELINEYQK 42
Spo0E COG5804
Stage 0 sporulation regulatory phosphatase Spo0E [Cell cycle control, cell division, ...
 1-49 3.08e-10

Stage 0 sporulation regulatory phosphatase Spo0E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444506  Cd Length: 55  Bit Score: 49.45  E-value: 3.08e-10
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....*....
gi 16078855  1 MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQYQKQR 49
Cdd:COG5804  3 MELEELLKKIEELREELNELAEEKGLTDPEVLELSQELDKLLNEYQRLK 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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