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Conserved domains on  [gi|15238017|ref|NP_199523|]
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BAX inhibitor 1 [Arabidopsis thaliana]

Protein Classification

BI-1 domain-containing protein( domain architecture ID 10179631)

BI-1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 25-236 2.83e-82

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


:

Pssm-ID: 198412  Cd Length: 213  Bit Score: 245.21  E-value: 2.83e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017  25 FRQISPAVQNHLKRVYLTLCCALVASAFGAYLHVLWNIGGILTTIGCIGTMIWLLSCP-PYEHQ-KRLSLLFVSAVLEGA 102
Cdd:cd10430   1 FNQISPSVQQHLKKVYLTLAVALLAAAVGAYVHMVINIGGLLTGLLSLGLSLWLAFTPsTGKNEpKRLGLLLGFAFLTGA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017 103 SVGPLIKVAIDVDPSILITAFVGTAIAFVCFSAAAMLARRREYLYLGGLLSSGLSMLmWLQFASSIFGGSASIFKFELYF 182
Cdd:cd10430  81 SLGPLLDLVIAINPSIIVTAFLGTAVIFACFSLAALLAKRREYLYLGGLLSSALSIL-LLVSLANIFGGSKFLFQAELYL 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 15238017 183 GLLIFVGYMVVDTQEIIEKAHLGDMDYVKHSLTLFTDFVAVFVRILIIMLKNSA 236
Cdd:cd10430 160 GLLVFCGFVLFDTQMIIEKAENGDRDYIWHALDLFVDFVALFRRLLIILAKKEK 213
 
Name Accession Description Interval E-value
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 25-236 2.83e-82

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 245.21  E-value: 2.83e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017  25 FRQISPAVQNHLKRVYLTLCCALVASAFGAYLHVLWNIGGILTTIGCIGTMIWLLSCP-PYEHQ-KRLSLLFVSAVLEGA 102
Cdd:cd10430   1 FNQISPSVQQHLKKVYLTLAVALLAAAVGAYVHMVINIGGLLTGLLSLGLSLWLAFTPsTGKNEpKRLGLLLGFAFLTGA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017 103 SVGPLIKVAIDVDPSILITAFVGTAIAFVCFSAAAMLARRREYLYLGGLLSSGLSMLmWLQFASSIFGGSASIFKFELYF 182
Cdd:cd10430  81 SLGPLLDLVIAINPSIIVTAFLGTAVIFACFSLAALLAKRREYLYLGGLLSSALSIL-LLVSLANIFGGSKFLFQAELYL 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 15238017 183 GLLIFVGYMVVDTQEIIEKAHLGDMDYVKHSLTLFTDFVAVFVRILIIMLKNSA 236
Cdd:cd10430 160 GLLVFCGFVLFDTQMIIEKAENGDRDYIWHALDLFVDFVALFRRLLIILAKKEK 213
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 33-231 3.36e-29

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 108.80  E-value: 3.36e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017    33 QNHLKRVYLTLCCALVASAFGAYL------------HVLWNIGGILTTIGCIGTMIWLLSCPPYEHQKRLSLLFVSAVLE 100
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLvlsspallfpslHPPLFWVLIIAPLGLLFGALLLARKRKYSSNVALLLLLAFTLLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017   101 GASVGPLIKVAidvDPSILITAFVGTAIAFVCFSAAAMLARRReYLYLGGLLSSGLSMLMWLQFASSIFGGSASIFKFeL 180
Cdd:pfam01027  81 GLTLGPLLLVY---TGAIIATAFLGTAAIFGGLSLYALTTKRD-LSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAI-S 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15238017   181 YFGLLIFVGYMVVDTQEIIEKA-HLGDMDYVKHSLTLFTDFVAVFVRILIIM 231
Cdd:pfam01027 156 YLGVLLFSGFILYDTQRIIKRYgEYGDYDAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 26-231 1.89e-09

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 55.96  E-value: 1.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017  26 RQISPAVQNHLKRVYLTLCCALVASAFGAYLHVlwNIGGILTTIGCIGTMIWLLSCPPY---------EHQKR----LSL 92
Cdd:COG0670  13 AASDAGLRKVLRNTYGLLALGLLLTALVAYLGM--ALPGLAALLFGSPGLFWVLLIAPLglvfllsklANRANsaaaLAL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017  93 LFVSAVLEGASVGPLIKVAI-DVDPSILITAFVGTAIAFVCFSAAAMLARRReylylggllssglsmlmwLQFASS---- 167
Cdd:COG0670  91 LFAYTALMGLTLSPILLVYTgLSGPASIAQAFGGTAATFGGLSLYGYTTKRD------------------LSFLGSflfm 152

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238017 168 -----IFGGSASIF--KFELYF-----GLLIFVGYMVVDTQEIIEKAHLGDMdYVKHSLTLFTDFVAVFVRILIIM 231
Cdd:COG0670 153 gliglIIASLVNIFlqSPALSLaisvaGVLLFSGLTLYDTQRIKHGYETNKQ-YIMAALSLYLDFINLFLSLLRLL 227
 
Name Accession Description Interval E-value
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 25-236 2.83e-82

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 245.21  E-value: 2.83e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017  25 FRQISPAVQNHLKRVYLTLCCALVASAFGAYLHVLWNIGGILTTIGCIGTMIWLLSCP-PYEHQ-KRLSLLFVSAVLEGA 102
Cdd:cd10430   1 FNQISPSVQQHLKKVYLTLAVALLAAAVGAYVHMVINIGGLLTGLLSLGLSLWLAFTPsTGKNEpKRLGLLLGFAFLTGA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017 103 SVGPLIKVAIDVDPSILITAFVGTAIAFVCFSAAAMLARRREYLYLGGLLSSGLSMLmWLQFASSIFGGSASIFKFELYF 182
Cdd:cd10430  81 SLGPLLDLVIAINPSIIVTAFLGTAVIFACFSLAALLAKRREYLYLGGLLSSALSIL-LLVSLANIFGGSKFLFQAELYL 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 15238017 183 GLLIFVGYMVVDTQEIIEKAHLGDMDYVKHSLTLFTDFVAVFVRILIIMLKNSA 236
Cdd:cd10430 160 GLLVFCGFVLFDTQMIIEKAENGDRDYIWHALDLFVDFVALFRRLLIILAKKEK 213
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 33-231 3.36e-29

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 108.80  E-value: 3.36e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017    33 QNHLKRVYLTLCCALVASAFGAYL------------HVLWNIGGILTTIGCIGTMIWLLSCPPYEHQKRLSLLFVSAVLE 100
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLvlsspallfpslHPPLFWVLIIAPLGLLFGALLLARKRKYSSNVALLLLLAFTLLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017   101 GASVGPLIKVAidvDPSILITAFVGTAIAFVCFSAAAMLARRReYLYLGGLLSSGLSMLMWLQFASSIFGGSASIFKFeL 180
Cdd:pfam01027  81 GLTLGPLLLVY---TGAIIATAFLGTAAIFGGLSLYALTTKRD-LSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAI-S 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15238017   181 YFGLLIFVGYMVVDTQEIIEKA-HLGDMDYVKHSLTLFTDFVAVFVRILIIM 231
Cdd:pfam01027 156 YLGVLLFSGFILYDTQRIIKRYgEYGDYDAILAALSLYLDFINLFLSLLRIL 207
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 32-231 1.89e-17

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 77.84  E-value: 1.89e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017  32 VQNHLKRVYLTLCCALVASAFGAYLHVLWNIG--GILTTIGCIGTMIWL---LSCPPYEHQKRLSLLFVSAVLEGASVGP 106
Cdd:cd06181   2 TKDFLRKVYMILALQLLLTAATATAFTVCDPGwyWSPALMGLLTSMLALmatAAMIRAKMPVNLILLFGFTGLMGYVVGP 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017 107 LIKVAidvDPSILITAFVGTAIAFVCFSAAAMLARRReyLYLGGLLSSGLSMLMWLQFASSIFGGSASIFKFELYFGLLI 186
Cdd:cd06181  82 LLFFY---GPTILLRALGGTALVFFGLTVYALQARKD--FLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVAAAVGLVL 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 15238017 187 FVGYMVVDTQEIIEKAHLGDMDYVKHSLTLFTDFVAVFVRILIIM 231
Cdd:cd06181 157 FCGFLLYDTQLIIHKAEVGPEDYINACISLYLDIINIFIRLLTIL 201
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 26-231 1.89e-09

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 55.96  E-value: 1.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017  26 RQISPAVQNHLKRVYLTLCCALVASAFGAYLHVlwNIGGILTTIGCIGTMIWLLSCPPY---------EHQKR----LSL 92
Cdd:COG0670  13 AASDAGLRKVLRNTYGLLALGLLLTALVAYLGM--ALPGLAALLFGSPGLFWVLLIAPLglvfllsklANRANsaaaLAL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017  93 LFVSAVLEGASVGPLIKVAI-DVDPSILITAFVGTAIAFVCFSAAAMLARRReylylggllssglsmlmwLQFASS---- 167
Cdd:COG0670  91 LFAYTALMGLTLSPILLVYTgLSGPASIAQAFGGTAATFGGLSLYGYTTKRD------------------LSFLGSflfm 152

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238017 168 -----IFGGSASIF--KFELYF-----GLLIFVGYMVVDTQEIIEKAHLGDMdYVKHSLTLFTDFVAVFVRILIIM 231
Cdd:COG0670 153 gliglIIASLVNIFlqSPALSLaisvaGVLLFSGLTLYDTQRIKHGYETNKQ-YIMAALSLYLDFINLFLSLLRLL 227
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 65-230 4.88e-07

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 49.14  E-value: 4.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017  65 ILTTIGCIGTMIWLLsCPPYEHQKRLSLLFVSAVLEGASVGplIKVAIdVDPSILITAFVGTAIAFVCFSAAAMLARRRe 144
Cdd:cd10429  70 LISLIGSLILLIALY-WKRHSHPVNLILLSLFTLCEAYTVG--LVVSF-YDGKIVLQALILTLGVFVGLTAYTFQTKRD- 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017 145 ylylggllssGLSMLMWLQFASSIFGGSASIFKFELY----------FGLLIFVGYMVVDTQEIIEKAHLGdmDYVKHSL 214
Cdd:cd10429 145 ----------FSSFGALLFILLWALILLALIFQFFPYsptfelvyagLGALLFSGYIVYDTQLIMKRLSPD--EYILAAI 212

                       170
                ....*....|....*.
gi 15238017 215 TLFTDFVAVFVRILII 230
Cdd:cd10429 213 SLYLDIINLFLSILRI 228
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 65-231 1.33e-06

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 48.15  E-value: 1.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017  65 ILTTIGCIGTMIWLLSCPPYEHQ--KRLSLLFVSAVLeGASVGPLIKVAidvdPSILITAFVGTAIAFVCFSAAAMLARR 142
Cdd:cd10431  84 GATLAAMIGSGMLVRSYTYPENPgaKHLAWLGHSGVQ-GAVLAPLCFLG----GPLLIRAALYTAGIVGGLSTVAACAPS 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017 143 RE-------YLYLGGLLSSGLSMLMWLQFASSIFGGSASIfkfELYFGLLIFVGYMVVDTQEIIEKAHLGDM------DY 209
Cdd:cd10431 159 EKflymggpLAIGLGVVFASSLGSMFLPPTTALGAGLYSV---SLYGGLVLFGGFLLYDTQKIIKRAETHPLygvrkyDP 235

                       170       180
                ....*....|....*....|..
gi 15238017 210 VKHSLTLFTDFVAVFVRILIIM 231
Cdd:cd10431 236 INASMSIYMDTINIFIRLVTIL 257
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 36-232 1.65e-04

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 41.42  E-value: 1.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017  36 LKRVYLTLCCALVASAFGAYLHVLWN---IGGILTTIGCIGtMIWLLscppyeHQKRLS-----LLFVSAVLEGASVGPL 107
Cdd:cd10433   7 LRNTYMLLSMTLAFSALGAGVSMAGGspiMGLLLTLVGAYG-LLFLI------EKTRNSawgivLVFAFTGFMGYTLGPI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017 108 IKVAIDVD--PSILITAFVGTAIAFVCFSAAAmLARRREYLYLGGLLSSGLSMLMWLQFASSIFGGSASIFKFELYFgLL 185
Cdd:cd10433  80 LNMYLALPngGQIIMTALGGTAAIFFGLSAYA-LTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAAF-VL 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 15238017 186 IFVGYMVVDTQEIIekaHLGDMDYVKHSLTLFTDFVAVFVRILIIML 232
Cdd:cd10433 158 FSSGFILYDTSRII---HGGETNYIMATVSLYVSIYNLFVSLLNLLG 201
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 31-231 9.92e-03

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 36.00  E-value: 9.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017  31 AVQNHLKRVYLTLCCALVASAFGAYL-----------HVLWNIGGILTTIGCIGTMIWLLSCPPYEhqKRLSLLFVSAVL 99
Cdd:cd10432   1 GLRSFMKKVYGLMAAGLLLTAVGAYVgastpallliaGSPLMWVLLIAELALVFGLSFRINKMSVA--TALPLFFAFAAL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238017 100 EGASVGPLIKVAIDVdpsILITAFVGTAIAFVCFSAAAMLARRreylylggllssglsmlMWLQFASSIFGG-----SAS 174
Cdd:cd10432  79 TGLTLSPILLVYTGA---SIAQAFFTTAATFGGLSLYGYTTKK-----------------DLSFLGSFLFMGligliIAS 138

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15238017 175 IFKFEL----------YFGLLIFVGYMVVDTQEIIEKAH-----LGDMDYVKHSLTLFTDFVAVFVRILIIM 231
Cdd:cd10432 139 LVNIFLqssalqfaisAIGVLIFSGLIAYDTQRIKRMYEagggeSGYKDAIMGALSLYLDFINLFLFLLRLF 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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