Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249132    14 VENVNQENDEKD-EKEQVANKGEPLalPLNVSEYCVPRGNRRRFRVRQPILQYRWDIMHRLGEPQARMRE-ENMERIGEE 91
Cdd:pfam04538   1 MEKACQENEGKPeEQGKVENEEEPE--DLEGGEPRKPRGNTRRGRVRQSVPNFREDIPNRHLSPEEMMREgDDMERFGEE 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 14249132    92 VRQLMEKLREKQLSHslravstdPPHHDHHDEF 124
Cdd:pfam04538  79 MRELRQKLREQQWRQ--------RPHRDHHYPF 103

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249132    14 VENVNQENDEKD-EKEQVANKGEPLalPLNVSEYCVPRGNRRRFRVRQPILQYRWDIMHRLGEPQARMRE-ENMERIGEE 91
Cdd:pfam04538   1 MEKACQENEGKPeEQGKVENEEEPE--DLEGGEPRKPRGNTRRGRVRQSVPNFREDIPNRHLSPEEMMREgDDMERFGEE 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 14249132    92 VRQLMEKLREKQLSHslravstdPPHHDHHDEF 124
Cdd:pfam04538  79 MRELRQKLREQQWRQ--------RPHRDHHYPF 103

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249132    14 VENVNQENDEKD-EKEQVANKGEPLalPLNVSEYCVPRGNRRRFRVRQPILQYRWDIMHRLGEPQARMRE-ENMERIGEE 91
Cdd:pfam04538   1 MEKACQENEGKPeEQGKVENEEEPE--DLEGGEPRKPRGNTRRGRVRQSVPNFREDIPNRHLSPEEMMREgDDMERFGEE 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 14249132    92 VRQLMEKLREKQLSHslravstdPPHHDHHDEF 124
Cdd:pfam04538  79 MRELRQKLREQQWRQ--------RPHRDHHYPF 103