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Conserved domains on  [gi|34577055|ref|NP_115521|]
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F-box only protein 30 [Homo sapiens]

Protein Classification

F-box protein( domain architecture ID 11240040)

F-box protein containing a TRAF-like zinc-finger, may function as the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515|GO:0008270
PubMed:  31898225|11178263|17210253|12665246
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_4 pfam15966
F-box;
609-724 4.58e-68

F-box;


:

Pssm-ID: 464958  Cd Length: 116  Bit Score: 219.47  E-value: 4.58e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577055   609 HNDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQWGKRKYPEGNSSWQIKEKVWRFSTAFCS 688
Cdd:pfam15966   1 NLDSLSSLPFEVLQHIASFLDSFSLSQLSLVSRLMREVCASLLQERGMVALQWEKKRYSHGGTSWQIKKKVWQFSTLFSP 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 34577055   689 VNEWKFADILSMADHLKKCSYNVVEKREEAIPLPCM 724
Cdd:pfam15966  81 VDSWKFDDVPSMSEHLKVCPFYEVERRTEPVPLPSM 116
zf-TRAF_2 pfam15965
TRAF-like zinc-finger;
7-98 5.51e-56

TRAF-like zinc-finger;


:

Pssm-ID: 464957  Cd Length: 92  Bit Score: 186.00  E-value: 5.51e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577055     7 HSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHSCKADEHRLLCPFERVPCLNSDFGCPFTMARNKVAEHLEMCPAS 86
Cdd:pfam15965   1 HEHCESCFSRRCQVKVEPSVSCAVISCPLGCGAVFHSCKLEEHQLLCPNEKVPCLNASYGCPFTLPRKQLAKHLEVCPAS 80

                          90
                  ....*....|..
gi 34577055    87 VVCCTMEWNRWP 98
Cdd:pfam15965  81 VVCCSMEWNRWP 92
 
Name Accession Description Interval E-value
F-box_4 pfam15966
F-box;
609-724 4.58e-68

F-box;


Pssm-ID: 464958  Cd Length: 116  Bit Score: 219.47  E-value: 4.58e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577055   609 HNDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQWGKRKYPEGNSSWQIKEKVWRFSTAFCS 688
Cdd:pfam15966   1 NLDSLSSLPFEVLQHIASFLDSFSLSQLSLVSRLMREVCASLLQERGMVALQWEKKRYSHGGTSWQIKKKVWQFSTLFSP 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 34577055   689 VNEWKFADILSMADHLKKCSYNVVEKREEAIPLPCM 724
Cdd:pfam15966  81 VDSWKFDDVPSMSEHLKVCPFYEVERRTEPVPLPSM 116
zf-TRAF_2 pfam15965
TRAF-like zinc-finger;
7-98 5.51e-56

TRAF-like zinc-finger;


Pssm-ID: 464957  Cd Length: 92  Bit Score: 186.00  E-value: 5.51e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577055     7 HSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHSCKADEHRLLCPFERVPCLNSDFGCPFTMARNKVAEHLEMCPAS 86
Cdd:pfam15965   1 HEHCESCFSRRCQVKVEPSVSCAVISCPLGCGAVFHSCKLEEHQLLCPNEKVPCLNASYGCPFTLPRKQLAKHLEVCPAS 80

                          90
                  ....*....|..
gi 34577055    87 VVCCTMEWNRWP 98
Cdd:pfam15965  81 VVCCSMEWNRWP 92
F-box_FBXO30 cd22174
F-box domain found in F-box only protein 30 (FBXO30) and similar proteins; FBXO30, also called ...
 613-661 3.35e-26

F-box domain found in F-box only protein 30 (FBXO30) and similar proteins; FBXO30, also called FBX30, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It is required for muscle atrophy following denervation. FBXO30 regulates mammopoiesis by targeting the bipolar mitotic kinesin Eg5. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438945  Cd Length: 49  Bit Score: 101.50  E-value: 3.35e-26
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 34577055 613 LSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQW 661
Cdd:cd22174   1 LSSLPFEVLQHIAGFLDGFSLCQLSRVSRLMRDVCASLLQARGMVILLW 49
FBOX smart00256
A Receptor for Ubiquitination Targets;
616-647 1.97e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.65  E-value: 1.97e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 34577055    616 LPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVC 647
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLI 32
 
Name Accession Description Interval E-value
F-box_4 pfam15966
F-box;
609-724 4.58e-68

F-box;


Pssm-ID: 464958  Cd Length: 116  Bit Score: 219.47  E-value: 4.58e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577055   609 HNDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQWGKRKYPEGNSSWQIKEKVWRFSTAFCS 688
Cdd:pfam15966   1 NLDSLSSLPFEVLQHIASFLDSFSLSQLSLVSRLMREVCASLLQERGMVALQWEKKRYSHGGTSWQIKKKVWQFSTLFSP 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 34577055   689 VNEWKFADILSMADHLKKCSYNVVEKREEAIPLPCM 724
Cdd:pfam15966  81 VDSWKFDDVPSMSEHLKVCPFYEVERRTEPVPLPSM 116
zf-TRAF_2 pfam15965
TRAF-like zinc-finger;
7-98 5.51e-56

TRAF-like zinc-finger;


Pssm-ID: 464957  Cd Length: 92  Bit Score: 186.00  E-value: 5.51e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577055     7 HSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHSCKADEHRLLCPFERVPCLNSDFGCPFTMARNKVAEHLEMCPAS 86
Cdd:pfam15965   1 HEHCESCFSRRCQVKVEPSVSCAVISCPLGCGAVFHSCKLEEHQLLCPNEKVPCLNASYGCPFTLPRKQLAKHLEVCPAS 80

                          90
                  ....*....|..
gi 34577055    87 VVCCTMEWNRWP 98
Cdd:pfam15965  81 VVCCSMEWNRWP 92
F-box_FBXO30 cd22174
F-box domain found in F-box only protein 30 (FBXO30) and similar proteins; FBXO30, also called ...
 613-661 3.35e-26

F-box domain found in F-box only protein 30 (FBXO30) and similar proteins; FBXO30, also called FBX30, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It is required for muscle atrophy following denervation. FBXO30 regulates mammopoiesis by targeting the bipolar mitotic kinesin Eg5. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438945  Cd Length: 49  Bit Score: 101.50  E-value: 3.35e-26
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 34577055 613 LSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQW 661
Cdd:cd22174   1 LSSLPFEVLQHIAGFLDGFSLCQLSRVSRLMRDVCASLLQARGMVILLW 49
F-box_FBXO30-like cd22101
F-box domain found in F-box only protein 30 (FBXO30), F-box only protein 40 (FBXO40) and ...
 613-657 4.29e-22

F-box domain found in F-box only protein 30 (FBXO30), F-box only protein 40 (FBXO40) and similar proteins; FBXO30, also called FBX30, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It is required for muscle atrophy following denervation. FBXO30 regulates mammopoiesis by targeting the bipolar mitotic kinesin Eg5. FBXO40, also called FBX40, or muscle disease-related protein, is a probable substrate-recognition component of an SCF-type E3 ubiquitin ligase complex that may function in myogenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438873  Cd Length: 45  Bit Score: 89.36  E-value: 4.29e-22
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 34577055 613 LSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMV 657
Cdd:cd22101   1 LSSLPFEILQHIARFLDSFSLCNLSLVSRLMREVCCSLLEERGMV 45
F-box_FBXO40 cd22175
F-box domain found in F-box only protein 40 (FBXO40) and similar proteins; FBXO40, also called ...
 613-661 1.41e-21

F-box domain found in F-box only protein 40 (FBXO40) and similar proteins; FBXO40, also called FBX40, or muscle disease-related protein, is a probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438946  Cd Length: 49  Bit Score: 88.03  E-value: 1.41e-21
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 34577055 613 LSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQW 661
Cdd:cd22175   1 LSSLPLEILRHIAGFLDSFSLSQLSQVSVLMRDVCATLLQERGMVSLVW 49
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 614-647 5.33e-07

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 46.28  E-value: 5.33e-07
                        10        20        30
                ....*....|....*....|....*....|....
gi 34577055 614 SSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVC 647
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELA 34
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 613-650 2.56e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 41.76  E-value: 2.56e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 34577055   613 LSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSL 650
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSL 38
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 613-652 2.71e-05

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 41.84  E-value: 2.71e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 34577055 613 LSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQ 652
Cdd:cd22117   1 FDLLPYELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLL 40
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 613-647 2.85e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 41.70  E-value: 2.85e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 34577055   613 LSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVC 647
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELA 35
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
 613-642 3.31e-04

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 38.77  E-value: 3.31e-04
                        10        20        30
                ....*....|....*....|....*....|
gi 34577055 613 LSSLPFEVLQHIAGFLDGFSLCQLSCVSKL 642
Cdd:cd22093   1 IERLPSEILLKILSYLDASSLLCISCVNKL 30
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 613-641 6.58e-04

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 38.06  E-value: 6.58e-04
                        10        20
                ....*....|....*....|....*....
gi 34577055 613 LSSLPFEVLQHIAGFLDGFSLCQLSCVSK 641
Cdd:cd22147   2 LSALPVELSLKILSYLDAKSLCRAAQVSK 30
FBOX smart00256
A Receptor for Ubiquitination Targets;
616-647 1.97e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.65  E-value: 1.97e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 34577055    616 LPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVC 647
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLI 32
F-box_EMI cd22086
F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI ...
 618-654 5.69e-03

F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI family includes FBX5 (EMI1) and FBX43 (EMI2), which are anaphase-promoting complex/cyclosome (APC/C) inhibitors that bind APC/C-CCD20 (Cell division cycle protein 20) and/or APC/C-CDH1 (CDC20 homologue 1) complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438858  Cd Length: 48  Bit Score: 35.55  E-value: 5.69e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 34577055 618 FEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSR 654
Cdd:cd22086   9 PHILSKILSYLSPEDLCRVSCVSKTWRQICLSDPKAN 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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