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Conserved domains on  [gi|14149769|ref|NP_115493|]
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meiotic nuclear division protein 1 homolog isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5124 super family cl34914
Protein predicted to be involved in meiotic recombination [Cell division and chromosome ...
 5-204 3.94e-44

Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only];


The actual alignment was detected with superfamily member COG5124:

Pssm-ID: 227453 [Multi-domain]  Cd Length: 209  Bit Score: 146.25  E-value: 3.94e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149769   5 KGLSAEEKRTRMMEIFSETKDVFQLKDLEKIAPKeKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKH 84
Cdd:COG5124   4 KGLSLAEKRRRLEAIFHDSKDFFQLKEVEKLGSK-KQIVLMTVKDLLQQLVDDGVVSVEKCGTSNIYWSFKSQTLQKLYD 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149769  85 KLEVLESQLSEGSQKHASLQKSIEKAKIGRCE---TEERTRLAKELSSLRD-QREQLKAEVEKYKDCDPQVVEEIRQANK 160
Cdd:COG5124  83 SSELLKKKIQEVKQDIATYKEEIDKEKATRRKkftEGQKNYNREALLEKRKkEQDEIKKKLNSLQKIEPIRWDAAKIQEK 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 14149769 161 VAKEAANRWTDNIFAIKSWAKRKFGFEENKIDRTFGIPEDFDYI 204
Cdd:COG5124 163 KKKVHLNKTTDNIEILIDYLCKKFFLKPEQIRKEFGIPEDLDEF 206
 
Name Accession Description Interval E-value
COG5124 COG5124
Protein predicted to be involved in meiotic recombination [Cell division and chromosome ...
 5-204 3.94e-44

Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only];


Pssm-ID: 227453 [Multi-domain]  Cd Length: 209  Bit Score: 146.25  E-value: 3.94e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149769   5 KGLSAEEKRTRMMEIFSETKDVFQLKDLEKIAPKeKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKH 84
Cdd:COG5124   4 KGLSLAEKRRRLEAIFHDSKDFFQLKEVEKLGSK-KQIVLMTVKDLLQQLVDDGVVSVEKCGTSNIYWSFKSQTLQKLYD 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149769  85 KLEVLESQLSEGSQKHASLQKSIEKAKIGRCE---TEERTRLAKELSSLRD-QREQLKAEVEKYKDCDPQVVEEIRQANK 160
Cdd:COG5124  83 SSELLKKKIQEVKQDIATYKEEIDKEKATRRKkftEGQKNYNREALLEKRKkEQDEIKKKLNSLQKIEPIRWDAAKIQEK 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 14149769 161 VAKEAANRWTDNIFAIKSWAKRKFGFEENKIDRTFGIPEDFDYI 204
Cdd:COG5124 163 KKKVHLNKTTDNIEILIDYLCKKFFLKPEQIRKEFGIPEDLDEF 206
Mnd1 pfam03962
Mnd1 HTH domain; This family of proteins includes MND1 from S. cerevisiae. The mnd1 protein ...
 16-75 7.96e-33

Mnd1 HTH domain; This family of proteins includes MND1 from S. cerevisiae. The mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair.


Pssm-ID: 461112  Cd Length: 60  Bit Score: 112.21  E-value: 7.96e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149769    16 MMEIFSETKDVFQLKDLEKIAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFP 75
Cdd:pfam03962   1 ILEIFHETKDFFTLKELEKLAPKEKGIVSQSVKDVLQSLVDDGLVDVEKIGSSNYYWSFP 60
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 77-178 6.52e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 36.96  E-value: 6.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149769     77 KALHARKHKLEVLESQLSEGSQKHASLQKSIEK--AKIGRCEtEERTRLAKELSSLRDQREQLKAEVEKYKDCDPQVVEE 154
Cdd:TIGR02168  705 KELEELEEELEQLRKELEELSRQISALRKDLARleAEVEQLE-ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                           90       100
                   ....*....|....*....|....
gi 14149769    155 IRQANKVAKEAANRWTDNIFAIKS 178
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDE 807
PRK11637 PRK11637
AmiB activator; Provisional
 78-145 9.90e-03

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 36.21  E-value: 9.90e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14149769   78 ALHARKHKLEVLESQLSEGSQKHASLQ--KSIEKAKIGRCETEERTRL---AKELSSLRDQREQLKAEVEKYK 145
Cdd:PRK11637 213 ARNERKKTLTGLESSLQKDQQQLSELRanESRLRDSIARAEREAKARAereAREAARVRDKQKQAKRKGSTYK 285
 
Name Accession Description Interval E-value
COG5124 COG5124
Protein predicted to be involved in meiotic recombination [Cell division and chromosome ...
 5-204 3.94e-44

Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only];


Pssm-ID: 227453 [Multi-domain]  Cd Length: 209  Bit Score: 146.25  E-value: 3.94e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149769   5 KGLSAEEKRTRMMEIFSETKDVFQLKDLEKIAPKeKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKH 84
Cdd:COG5124   4 KGLSLAEKRRRLEAIFHDSKDFFQLKEVEKLGSK-KQIVLMTVKDLLQQLVDDGVVSVEKCGTSNIYWSFKSQTLQKLYD 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149769  85 KLEVLESQLSEGSQKHASLQKSIEKAKIGRCE---TEERTRLAKELSSLRD-QREQLKAEVEKYKDCDPQVVEEIRQANK 160
Cdd:COG5124  83 SSELLKKKIQEVKQDIATYKEEIDKEKATRRKkftEGQKNYNREALLEKRKkEQDEIKKKLNSLQKIEPIRWDAAKIQEK 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 14149769 161 VAKEAANRWTDNIFAIKSWAKRKFGFEENKIDRTFGIPEDFDYI 204
Cdd:COG5124 163 KKKVHLNKTTDNIEILIDYLCKKFFLKPEQIRKEFGIPEDLDEF 206
Mnd1 pfam03962
Mnd1 HTH domain; This family of proteins includes MND1 from S. cerevisiae. The mnd1 protein ...
 16-75 7.96e-33

Mnd1 HTH domain; This family of proteins includes MND1 from S. cerevisiae. The mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair.


Pssm-ID: 461112  Cd Length: 60  Bit Score: 112.21  E-value: 7.96e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149769    16 MMEIFSETKDVFQLKDLEKIAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFP 75
Cdd:pfam03962   1 ILEIFHETKDFFTLKELEKLAPKEKGIVSQSVKDVLQSLVDDGLVDVEKIGSSNYYWSFP 60
LZ3wCH pfam18517
Leucine zipper with capping helix domain; This domain is found at the C-terminal region of ...
 151-204 6.47e-19

Leucine zipper with capping helix domain; This domain is found at the C-terminal region of Hop2 and Mnd1 proteins. In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex. Hop2 (for homologous pairing; also known as TBPIP) is expressed specifically during meiosis, same as Mnd1 (for meiotic nuclear divisions 1). The C-terminal region of both Hop2 and Mnd1, folds into three alpha-helices that are interrupted by two short non-helical regions. These alpha-helices of the two proteins together form a parallel coiled coil that provides the major interface for heterodimer formation. The non-helical regions form substantially kinked junctions between adjacent leucine zippers: the LZ1-LZ2 and LZ2-LZ3 junctions.This domain is the C-terminal segment of Hop2 and Mnd1 which folds back onto the C-terminal leucine zipper (LZ3) to form a helical bundle-like structure, hence designated LZ3wCH (for LZ3 with capping helices). The LZ3wCH region plays a role in interacting with the Dmc1 nucleofilament.


Pssm-ID: 465789  Cd Length: 55  Bit Score: 76.43  E-value: 6.47e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 14149769   151 VVEEIRQANKVAKEAANRWTDNIFAIKSWAKRKFGFEENKIDRTFGIPEDFDYI 204
Cdd:pfam18517   2 TPEEKKKATKVAKEAANRWTDNIFDIKSWIKEKFPKSKKELNEEFGIETDEDYG 55
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 77-178 6.52e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 36.96  E-value: 6.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149769     77 KALHARKHKLEVLESQLSEGSQKHASLQKSIEK--AKIGRCEtEERTRLAKELSSLRDQREQLKAEVEKYKDCDPQVVEE 154
Cdd:TIGR02168  705 KELEELEEELEQLRKELEELSRQISALRKDLARleAEVEQLE-ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                           90       100
                   ....*....|....*....|....
gi 14149769    155 IRQANKVAKEAANRWTDNIFAIKS 178
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDE 807
PRK11637 PRK11637
AmiB activator; Provisional
 78-145 9.90e-03

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 36.21  E-value: 9.90e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14149769   78 ALHARKHKLEVLESQLSEGSQKHASLQ--KSIEKAKIGRCETEERTRL---AKELSSLRDQREQLKAEVEKYK 145
Cdd:PRK11637 213 ARNERKKTLTGLESSLQKDQQQLSELRanESRLRDSIARAEREAKARAereAREAARVRDKQKQAKRKGSTYK 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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