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Conserved domains on  [gi|13569942|ref|NP_112229|]
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keratin-associated protein 1-1 [Homo sapiens]

Protein Classification

Keratin_B2 domain-containing protein( domain architecture ID 12021880)

Keratin_B2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 1-177 1.12e-40

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 134.92  E-value: 1.12e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569942     1 MACCQTSFCGFPSCSTSGTCGSSCCQPSCCETSSCQPRCCETSCCQPSCCQTSFCgfpSFSTGGTCDSSCCQPSCCETSC 80
Cdd:pfam01500   1 MACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCC---RPTCQPCCQTSCCQPTCCQTSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569942    81 CQPSCYQTSScgtgcgigggigyGQEGSSGAVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPSCCQLHHAEASCCRPSYCG 160
Cdd:pfam01500  78 CQTGCGGIGY-------------GQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCG 144

                         170
                  ....*....|....*..
gi 13569942   161 QSCCRPVCCCYCSEPTC 177
Cdd:pfam01500 145 QSCCRPACCCQCSEPTC 161
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 1-177 1.12e-40

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 134.92  E-value: 1.12e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569942     1 MACCQTSFCGFPSCSTSGTCGSSCCQPSCCETSSCQPRCCETSCCQPSCCQTSFCgfpSFSTGGTCDSSCCQPSCCETSC 80
Cdd:pfam01500   1 MACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCC---RPTCQPCCQTSCCQPTCCQTSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569942    81 CQPSCYQTSScgtgcgigggigyGQEGSSGAVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPSCCQLHHAEASCCRPSYCG 160
Cdd:pfam01500  78 CQTGCGGIGY-------------GQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCG 144

                         170
                  ....*....|....*..
gi 13569942   161 QSCCRPVCCCYCSEPTC 177
Cdd:pfam01500 145 QSCCRPACCCQCSEPTC 161
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 1-177 1.12e-40

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 134.92  E-value: 1.12e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569942     1 MACCQTSFCGFPSCSTSGTCGSSCCQPSCCETSSCQPRCCETSCCQPSCCQTSFCgfpSFSTGGTCDSSCCQPSCCETSC 80
Cdd:pfam01500   1 MACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCC---RPTCQPCCQTSCCQPTCCQTSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569942    81 CQPSCYQTSScgtgcgigggigyGQEGSSGAVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPSCCQLHHAEASCCRPSYCG 160
Cdd:pfam01500  78 CQTGCGGIGY-------------GQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCG 144

                         170
                  ....*....|....*..
gi 13569942   161 QSCCRPVCCCYCSEPTC 177
Cdd:pfam01500 145 QSCCRPACCCQCSEPTC 161
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
24-84 1.28e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.53  E-value: 1.28e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13569942    24 CCQPSCCETSSCQPRCCETSCCQPSCCQTsfcgfpsfstggtcdsSCCQPSCCETSCCQPS 84
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQP----------------SCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
9-51 2.34e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 45.45  E-value: 2.34e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 13569942     9 CGFPSCSTSGTCGSSCCQPSCCETSSCQPRCCETSCCQPSCCQ 51
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQ 43
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
39-91 1.45e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 43.14  E-value: 1.45e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 13569942    39 CCETSCCQPSCCQTSFCGfpsfstggtcdSSCCQPSCCETSCCQPSCYQTSSC 91
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQ-----------PSCCQPSCCQPSCCRPSCCRSSCC 42
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 12-142 1.78e-05

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 42.88  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569942    12 PSCSTSGTCGSSCCQPSCCETSSCQPRCCETSCCQPSCCQTSFCGFPSFSTGGTCDSSCCQPSCCE-----TSCCQPSCY 86
Cdd:pfam05287  43 PSSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCVPSPCQRSCYSPRTSCVCSPCQTTSAGslgfgSSSCQSLGY 122

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 13569942    87 QTSSCGTGCGIGGGIGYGQEGSSG--AVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPS 142
Cdd:pfam05287 123 GSNSCQPLGCGSSGFRPLGCLSKGfqSLGYGSSFCRPSYVSSRSYQPSCFRPSCGSGF 180
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 4-70 1.67e-03

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 37.95  E-value: 1.67e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13569942     4 CQTSFcGFPSCSTSGTCGSSCCQPSCCETSSCQPRCCeTSCCQPSCCQTSFCGFPSFSTGGTCDSSC 70
Cdd:pfam03137 372 CSTSA-YSPVCGSDGGYTSPCPCGAGCSSSSGAGKST-YICNCCCSCGSQDSGGNGSATPGKCPSDC 436
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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