|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
6-308 |
0e+00 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 678.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 6 HCVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKV 85
Cdd:cd19108 1 QRVKLNDGHFIPVLGFGTYAPEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 86 WCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGV 165
Cdd:cd19108 81 WCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 166 SNFNYRQLEMILNKPGLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPVLGSMA 245
Cdd:cd19108 161 SNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEWVDQNSPVLLEDPVLCALA 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126090770 246 KKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRYIPA 308
Cdd:cd19108 241 KKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYLPA 303
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
13-319 |
1.88e-172 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 480.45 E-value: 1.88e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 13 GNFIPVLGFGT-ALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWCTSLH 91
Cdd:cd19109 1 GNSIPIIGLGTySEPKTTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWNTCHP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 92 PELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYR 171
Cdd:cd19109 81 PELVRPTLERTLKVLQLDYVDLYIIEMPMAFKPGDEIYPRDENGKWLYHKTNLCATWEALEACKDAGLVKSIGVSNFNRR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 172 QLEMILNKPGLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPVLGSMAKKYNRT 251
Cdd:cd19109 161 QLELILNKPGLKHKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRDPIWVNVSSPPLLEDPLLNSIGKKYNKT 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126090770 252 PALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRYIPAAIFKGHPNWPF 319
Cdd:cd19109 241 AAQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNVRYVELLMWRDHPEYPF 308
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
16-323 |
1.01e-126 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 364.43 E-value: 1.01e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTalpLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWCTSLHPELV 95
Cdd:cd19107 4 MPILGLGT---WKSPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEKGLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 96 RASLERSLQKLQFDYVDLYLIHYPMALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEM 175
Cdd:cd19107 81 KGACQKTLSDLKLDYLDLYLIHWPTGFKPGKELFPLDESGNVIPSDTTFLDTWEAMEELVDEGLVKAIGVSNFNHLQIER 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 176 ILNKPGLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGT-QRygGWVDQNSPVLLDEPVLGSMAKKYNRTPAL 254
Cdd:cd19107 161 ILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSpDR--PWAKPEDPSLLEDPKIKEIAAKHNKTTAQ 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126090770 255 IALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRYIPAAIFKGHPNWPFLDEY 323
Cdd:cd19107 239 VLIRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATILSFNRNWRACALLSCSSHKDYPFHAEY 307
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
10-306 |
1.42e-123 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 356.31 E-value: 1.42e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 10 LNDGNFIPVLGFGTAlplecpKSK---AKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKI-ADGTVRREDIFYTSKV 85
Cdd:cd19106 1 LHTGQKMPLIGLGTW------KSKpgqVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKVgPGKAVPREDLFVTSKL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 86 WCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGV 165
Cdd:cd19106 75 WNTKHHPEDVEPALRKTLKDLQLDYLDLYLIHWPYAFERGDNPFPKNPDGTIRYDSTHYKETWKAMEKLVDKGLVKAIGL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 166 SNFNYRQLEMILNKPglKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGT-QRygGWVDQNSPVLLDEPVLGSM 244
Cdd:cd19106 155 SNFNSRQIDDILSVA--RIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLGSpDR--PWAKPDEPVLLEEPKVKAL 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 126090770 245 AKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRYI 306
Cdd:cd19106 231 AKKYNKSPAQILLRWQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNRNWRYI 292
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
16-297 |
2.82e-118 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 341.00 E-value: 2.82e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTALPlecPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIadgtVRREDIFYTSKVWCTSLHPELV 95
Cdd:cd19071 1 MPLIGLGTYKL---KPEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESG----VPREELFITTKLWPTDHGYERV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 96 RASLERSLQKLQFDYVDLYLIHYPMALKPGEenfpvdehgklifDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEM 175
Cdd:cd19071 74 REALEESLKDLGLDYLDLYLIHWPVPGKEGG-------------SKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEE 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 176 ILNKPglKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGgwvdqnspvLLDEPVLGSMAKKYNRTPALI 255
Cdd:cd19071 141 LLAAA--RIKPAVNQIELHPYLQQKELVEFCKEHGIVVQAYSPLGRGRRP---------LLDDPVLKEIAKKYGKTPAQV 209
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 126090770 256 ALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19071 210 LLRWALQRGVVVIPKSSNPERIKENLDVFDFELSEEDMAAID 251
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
16-323 |
2.19e-116 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 338.09 E-value: 2.19e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGT--ALPlecpkSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWCTSLHPE 93
Cdd:cd19110 4 IPAVGLGTwkASP-----GEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 94 LVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQL 173
Cdd:cd19110 79 LVKTACTRSLKALKLNYLDLYLIHWPMGFKPGEPDLPLDRSGMVIPSDTDFLDTWEAMEDLVIEGLVKNIGVSNFNHEQL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 174 EMILNKPGLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQryGGWVDqnspvLLDEPVLGSMAKKYNRTPA 253
Cdd:cd19110 159 ERLLNKPGLRVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLGGS--CEGVD-----LIDDPVIQRIAKKHGKSPA 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 254 LIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRYIPAAIFKGHPNWPFLDEY 323
Cdd:cd19110 232 QILIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRLATFPITENHKDYPFHIEY 301
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
7-306 |
3.76e-114 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 331.94 E-value: 3.76e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 7 CVILNDGNFIPVLGFGTALPLEcpKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVW 86
Cdd:cd19116 2 TIKLNDGNEIPAIALGTWKLKD--DEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDLFITTKLW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 87 CTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKpgeENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVS 166
Cdd:cd19116 80 NSYHEREQVEPALRESLKRLGLDYVDLYLIHWPVAFK---ENNDSESNGDGSLSDIDYLETWRGMEDLVKLGLTRSIGVS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 167 NFNYRQLEMILNkpGLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGwvDQNSPVLLDEPVLGSMAK 246
Cdd:cd19116 157 NFNSEQINRLLS--NCNIKPAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFGRLVPRG--QTNPPPRLDDPTLVAIAK 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 247 KYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRYI 306
Cdd:cd19116 233 KYGKTTAQIVLRYLIDRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNTNQRVY 292
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
7-304 |
7.84e-107 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 313.96 E-value: 7.84e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 7 CVILNDGNFIPVLGFGTAlplecpKSKAKELT---KIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTS 83
Cdd:cd19154 3 SITLSNGVKMPLIGLGTW------QSKGAEGItavRTALKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDLFITT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 84 KVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSI 163
Cdd:cd19154 77 KLWTHEHAPEDVEEALRESLKKLQLEYVDLYLIHAPAAFKDDEGESGTMENGMSIHDAVDVEDVWRGMEKVYDEGLTKAI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 164 GVSNFNYRQLEMILNKPglKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGT------QRYGGWvdQNSPVLLD 237
Cdd:cd19154 157 GVSNFNNDQIQRILDNA--RVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLGSpgranfTKSTGV--SPAPNLLQ 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 126090770 238 EPVLGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMR 304
Cdd:cd19154 233 DPIVKAIAEKHGKTPAQVLLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKSLR 299
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
12-307 |
4.51e-106 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 310.06 E-value: 4.51e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 12 DGNFIPVLGFGTALPlecPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRskiADGtVRREDIFYTSKVWCTSLH 91
Cdd:COG0656 1 NGVEIPALGLGTWQL---PGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA---ASG-VPREELFVTTKVWNDNHG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 92 PELVRASLERSLQKLQFDYVDLYLIHYPMalkpgeenfpvdehgklifdRVDLCATWEAMEKCKDAGLTKSIGVSNFNYR 171
Cdd:COG0656 74 YDDTLAAFEESLERLGLDYLDLYLIHWPG--------------------PGPYVETWRALEELYEEGLIRAIGVSNFDPE 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 172 QLEMILNKPGlkYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGtqrYGGwvdqnspvLLDEPVLGSMAKKYNRT 251
Cdd:COG0656 134 HLEELLAETG--VKPAVNQVELHPYLQQRELLAFCREHGIVVEAYSPLG---RGK--------LLDDPVLAEIAEKHGKT 200
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 126090770 252 PALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRYIP 307
Cdd:COG0656 201 PAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGERLGP 256
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
8-306 |
9.83e-103 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 303.18 E-value: 9.83e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 8 VILNDGNFIPVLGFGTalpLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWC 87
Cdd:cd19123 4 LPLSNGDLIPALGLGT---WKSKPGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDLWITSKLWN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 88 TSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGeENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSN 167
Cdd:cd19123 81 NSHAPEDVLPALEKTLADLQLDYLDLYLMHWPVALKKG-VGFPESGEDLLSLSPIPLEDTWRAMEELVDKGLCRHIGVSN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 168 FNYRQLEMILNKPglKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGT-QRYGGWVDQNSPVLLDEPVLGSMAK 246
Cdd:cd19123 160 FSVKKLEDLLATA--RIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLGSgDRPAAMKAEGEPVLLEDPVINKIAE 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 247 KYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRYI 306
Cdd:cd19123 238 KHGASPAQVLIAWAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAALDRHHRYV 297
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
10-304 |
3.13e-98 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 291.17 E-value: 3.13e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 10 LNDGNFIPVLGFGTalpLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWCTS 89
Cdd:cd19125 5 LNTGAKIPAVGLGT---WQADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDLFITSKLWCTD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 90 LHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENFpvdehGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFN 169
Cdd:cd19125 82 HAPEDVPPALEKTLKDLQLDYLDLYLIHWPVRLKKGAHMP-----EPEEVLPPDIPSTWKAMEKLVDSGKVRAIGVSNFS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 170 YRQLEMILNKPglKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRyGGWVDQNspvLLDEPVLGSMAKKYN 249
Cdd:cd19125 157 VKKLEDLLAVA--RVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAYSPLGSPG-TTWVKKN---VLKDPIVTKVAEKLG 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 126090770 250 RTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMR 304
Cdd:cd19125 231 KTPAQVALRWGLQRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSIEQQRR 285
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
12-299 |
1.86e-96 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 286.47 E-value: 1.86e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 12 DGNFIPVLGFGTALPLECPKsKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVR-REDIFYTSKVWCTSL 90
Cdd:cd19124 1 SGQTMPVIGMGTASDPPSPE-DIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVKsRDELFVTSKLWCSDA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 91 HPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENFPVDEHgklIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNY 170
Cdd:cd19124 80 HPDLVLPALKKSLRNLQLEYVDLYLIHWPVSLKPGKFSFPIEEE---DFLPFDIKGVWEAMEECQRLGLTKAIGVSNFSC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 171 RQLEMILNKPglKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGwvdqNSPVLLDEPVLGSMAKKYNR 250
Cdd:cd19124 157 KKLQELLSFA--TIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGAPGTKW----GSNAVMESDVLKEIAAAKGK 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 126090770 251 TPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGL 299
Cdd:cd19124 231 TVAQVSLRWVYEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKISEI 279
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
13-297 |
2.61e-90 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 270.64 E-value: 2.61e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 13 GNFIPVLGFGTALPL-----ECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRskiaDGTVRREDIFYTSKVWC 87
Cdd:cd19120 1 GSKIPAIAFGTGTAWyksgdDDIQRDLVDSVKLALKAGFRHIDTAEMYGNEKEVGEALK----ESGVPREDLFITTKVSP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 88 TSLHPelvRASLERSLQKLQFDYVDLYLIHYPmalkpgeenFPVDEHGKlifdrvDLCATWEAMEKCKDAGLTKSIGVSN 167
Cdd:cd19120 77 GIKDP---REALRKSLAKLGVDYVDLYLIHSP---------FFAKEGGP------TLAEAWAELEALKDAGLVRSIGVSN 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 168 FNYRQLEMILNKPglKYKPVCNQVECHPYLN--QMKLLDFCKSKDIVLVAYGVLGTQryggWVDQNSPVlldEPVLGSMA 245
Cdd:cd19120 139 FRIEDLEELLDTA--KIKPAVNQIEFHPYLYpqQPALLEYCREHGIVVSAYSPLSPL----TRDAGGPL---DPVLEKIA 209
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 126090770 246 KKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19120 210 EKYGVTPAQVLLRWALQKGIVVVTTSSKEERMKEYLEAFDFELTEEEVEEID 261
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
7-304 |
4.75e-87 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 263.62 E-value: 4.75e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 7 CVILNDGNFIPVLGFGTALpleCPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVW 86
Cdd:cd19155 3 CVTFNNGEKMPVVGLGTWQ---SSPEEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKREELFIVTKLP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 87 CTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALK-PGEENFPVDEHGKLIFD-RVDLCATWEAMEKCKDAGLTKSIG 164
Cdd:cd19155 80 PGGNRREKVEKFLLKSLEKLQLDYVDLYLIHFPVGSLsKEDDSGKLDPTGEHKQDyTTDLLDIWKAMEAQVDQGLTRSIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 165 VSNFNYRQLEMILNKPglKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYG------GWVDQNSPVLLDE 238
Cdd:cd19155 160 LSNFNREQMARILKNA--RIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAPLGSPGAAhfspgtGSPSGSSPDLLQD 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126090770 239 PVLGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMR 304
Cdd:cd19155 238 PVVKAIAERHGKSPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDKNIR 303
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
11-283 |
2.43e-86 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 261.24 E-value: 2.43e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 11 NDGNFIPVLGFGTALPlecPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWCTSL 90
Cdd:cd19129 1 NGSGAIPALGFGTLIP---DPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRREDLFVTTKLWNTNH 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 91 HPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENFPVDEHGKLIFDR-VDLCATWEAMEKCKDAGLTKSIGVSNFN 169
Cdd:cd19129 78 RPERVKPAFEASLKRLQLDYLDLYLIHTPFAFQPGDEQDPRDANGNVIYDDgVTLLDTWRAMERLVDEGRCKAIGLSDVS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 170 YRQLEMILNKPglKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGtqryggwvDQNSPVLLDEPVLGSMAKKYN 249
Cdd:cd19129 158 LEKLREIFEAA--RIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLG--------HGMEPKLLEDPVITAIARRVN 227
|
250 260 270
....*....|....*....|....*....|....
gi 126090770 250 RTPALIALRYQLQRGIVVLNTSLKEERIKENMQV 283
Cdd:cd19129 228 KTPAQVLLAWAIQRGTALLTTSKTPSRIRENFDI 261
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
16-297 |
8.09e-85 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 255.66 E-value: 8.09e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTalpLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIrskiADGTVRREDIFYTSKVWCTSLHPELV 95
Cdd:cd19073 1 IPALGLGT---WQLRGDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAI----AESGVPREDLFITTKVWRDHLRPEDL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 96 RASLERSLQKLQFDYVDLYLIHYPMALKPGEEnfpvdehgklifdrvdlcaTWEAMEKCKDAGLTKSIGVSNFNYRQLEM 175
Cdd:cd19073 74 KKSVDRSLEKLGTDYVDLLLIHWPNPTVPLEE-------------------TLGALKELKEAGKVKSIGVSNFTIELLEE 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 176 ILNKPGLkyKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGtqrYGGwvdqnspvLLDEPVLGSMAKKYNRTPALI 255
Cdd:cd19073 135 ALDISPL--PIAVNQVEFHPFLYQAELLEYCRENDIVITAYSPLA---RGE--------VLRDPVIQEIAEKYDKTPAQV 201
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 126090770 256 ALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19073 202 ALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSEDVAKID 243
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
13-305 |
1.44e-84 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 256.66 E-value: 1.44e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 13 GNFIPVLGFGTalpLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWCTSLHP 92
Cdd:cd19111 1 GFPMPVIGLGT---YQSPPEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEVFITTKLPPVYLEF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 93 ELVRASLERSLQKLQFDYVDLYLIHYPMAlkpgeenFPVDEHGKLIFD-RVDLCATWEAMEKCKDAGLTKSIGVSNFNYR 171
Cdd:cd19111 78 KDTEKSLEKSLENLKLPYVDLYLIHHPCG-------FVNKKDKGERELaSSDVTSVWRAMEALVSEGKVKSIGLSNFNPR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 172 QLEMILNKPglKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQrygGWVDQNS----PVLLDEPVLGSMAKK 247
Cdd:cd19111 151 QINKILAYA--KVKPSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLGSP---GRANQSLwpdqPDLLEDPTVLAIAKE 225
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 126090770 248 YNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRY 305
Cdd:cd19111 226 LDKTPAQVLLRFVLQRGTGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRNMKY 283
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
8-313 |
2.87e-84 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 256.64 E-value: 2.87e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 8 VILNDGNFIPVLGFGTalpLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWc 87
Cdd:cd19112 3 ITLNSGHKMPVIGLGV---WRMEPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDLFITTKLW- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 88 TSLHpELVRASLERSLQKLQFDYVDLYLIHYPMALKP---GEENFPVDEHGKL-IFDRVDLCATWEAMEKCKDAGLTKSI 163
Cdd:cd19112 79 NSDH-GHVIEACKDSLKKLQLDYLDLYLVHFPVATKHtgvGTTGSALGEDGVLdIDVTISLETTWHAMEKLVSAGLVRSI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 164 GVSNFnyrqlEMILNKPGLKY---KPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGtqryGG-----WVDQNSPvl 235
Cdd:cd19112 158 GISNY-----DIFLTRDCLAYskiKPAVNQIETHPYFQRDSLVKFCQKHGISVTAHTPLG----GAaanaeWFGSVSP-- 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126090770 236 LDEPVLGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRYIPAAIFKG 313
Cdd:cd19112 227 LDDPVLKDLAKKYGKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLDRKYRTNQPAKFWG 304
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
10-301 |
2.80e-83 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 253.19 E-value: 2.80e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 10 LNDGNFIPVLGFGTAlplecpKSKAKELTK---IAIDAGFHHFDSASVYNTEDHVGEAIRskiaDGTVRREDIFYTSKVW 86
Cdd:cd19117 8 LNTGAEIPAVGLGTW------QSKPNEVAKaveAALKAGYRHIDTAAIYGNEEEVGQGIK----DSGVPREEIFITTKLW 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 87 CTSLHPelVRASLERSLQKLQFDYVDLYLIHYPMALKP-GEENFPVDEHGKLIFDRV-DLCATWEAMEKCKDAGLTKSIG 164
Cdd:cd19117 78 CTWHRR--VEEALDQSLKKLGLDYVDLYLMHWPVPLDPdGNDFLFKKDDGTKDHEPDwDFIKTWELMQKLPATGKVKAIG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 165 VSNFNYRQLEMILNKPGLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTqryggwvdQNSPvLLDEPVLGSM 244
Cdd:cd19117 156 VSNFSIKNLEKLLASPSAKIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGS--------TNAP-LLKEPVIIKI 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 126090770 245 AKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEfqLSSEDMKVLDGLNR 301
Cdd:cd19117 227 AKKHGKTPAQVIISWGLQRGYSVLPKSVTPSRIESNFKLFT--LSDEEFKEIDELHK 281
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
10-299 |
1.01e-82 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 251.56 E-value: 1.01e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 10 LNDGNFIPVLGFGTALplecpkSKAKELT---KIAIDAGFHHFDSASVYNTEDHVGEAIRSKIAD-GTVRREDIFYTSKV 85
Cdd:cd19118 1 LNTGNKIPAIGLGTWQ------AEPGEVGaavKIALKAGYRHLDLAKVYQNQHEVGQALKELLKEePGVKREDLFITSKL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 86 WCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEE----NFPVDEHGKLIFDR-VDLCATWEAMEKCKDAGLT 160
Cdd:cd19118 75 WNNSHRPEYVEPALDDTLKELGLDYLDLYLIHWPVAFKPTGDlnplTAVPTNGGEVDLDLsVSLVDTWKAMVELKKTGKV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 161 KSIGVSNFNYRQLEMILNKPGLkyKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGwvdqnsPVLLDEPV 240
Cdd:cd19118 155 KSIGVSNFSIDHLQAIIEETGV--VPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLGNNLAGL------PLLVQHPE 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 126090770 241 LGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEfqLSSEDMKVLDGL 299
Cdd:cd19118 227 VKAIAAKLGKTPAQVLIAWGIQRGHSVIPKSVTPSRIRSNFEQVE--LSDDEFNAVTAL 283
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
16-299 |
2.07e-82 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 250.24 E-value: 2.07e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTAlplecpKSKAKELTKIAIDA----GFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWCTSLH 91
Cdd:cd19136 1 MPILGLGTF------RLRGEEEVRQAVDAalkaGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDIFITSKLAPKDQG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 92 PELVRASLERSLQKLQFDYVDLYLIHYpmalkPGEENFPVD--EHGKLifdRVDlcaTWEAMEKCKDAGLTKSIGVSNFN 169
Cdd:cd19136 75 YEKARAACLGSLERLGTDYLDLYLIHW-----PGVQGLKPSdpRNAEL---RRE---SWRALEDLYKEGKLRAIGVSNYT 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 170 YRQLEMILNKPglKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYggwvdqnspVLLDEPVLGSMAKKYN 249
Cdd:cd19136 144 VRHLEELLKYC--EVPPAVNQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGSGDL---------RLLEDPTVLAIAKKYG 212
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 126090770 250 RTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGL 299
Cdd:cd19136 213 RTPAQVLLRWALQQGIGVIPKSTNPERIAENIKVFDFELSEEDMAELNAL 262
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
8-300 |
4.04e-82 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 249.03 E-value: 4.04e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 8 VILNDGNFIPVLGFGT-ALPlecPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRskiaDGTVRREDIFYTSKVW 86
Cdd:cd19133 1 VTLNNGVEMPILGFGVfQIP---DPEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIK----KSGIPREELFITTKLW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 87 CTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMAlkpgeenfpvDEHGklifdrvdlcaTWEAMEKCKDAGLTKSIGVS 166
Cdd:cd19133 74 IQDAGYEKAKKAFERSLKRLGLDYLDLYLIHQPFG----------DVYG-----------AWRAMEELYKEGKIRAIGVS 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 167 NFNYRQLEMILnkPGLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGgwvdqnspvLLDEPVLGSMAK 246
Cdd:cd19133 133 NFYPDRLVDLI--LHNEVKPAVNQIETHPFNQQIEAVEFLKKYGVQIEAWGPFAEGRNN---------LFENPVLTEIAE 201
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 126090770 247 KYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLN 300
Cdd:cd19133 202 KYGKSVAQVILRWLIQRGIVVIPKSVRPERIAENFDIFDFELSDEDMEAIAALD 255
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
7-307 |
8.11e-82 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 248.85 E-value: 8.11e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 7 CVILNDGNFIPVLGFGTALPLEcpKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRskiaDGTVRREDIFYTSKVW 86
Cdd:cd19157 1 TVTLNNGVKMPWLGLGVFKVEE--GSEVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGIK----ESGIPREELFITSKVW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 87 CTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEenfpvdehgklifdrvdlcaTWEAMEKCKDAGLTKSIGVS 166
Cdd:cd19157 75 NADQGYDSTLKAFEASLERLGLDYLDLYLIHWPVKGKYKE--------------------TWKALEKLYKDGRVRAIGVS 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 167 NFNYRQLEMILNKPglKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRyggwvdqnspvLLDEPVLGSMAK 246
Cdd:cd19157 135 NFQVHHLEDLLADA--EIVPMVNQVEFHPRLTQKELRDYCKKQGIQLEAWSPLMQGQ-----------LLDNPVLKEIAE 201
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126090770 247 KYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRYIP 307
Cdd:cd19157 202 KYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVFDFELSQEDMDKIDALNENLRVGP 262
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
8-305 |
8.12e-79 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 242.74 E-value: 8.12e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 8 VILNDGNFIPVLGFGTalpLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWC 87
Cdd:cd19113 3 IKLNSGYKMPSVGFGC---WKLDNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKLWN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 88 TSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALK--PGEENFP----VDEHGKLIFDRVDLCATWEAMEKCKDAGLTK 161
Cdd:cd19113 80 NFHDPKNVETALNKTLSDLKLDYVDLFLIHFPIAFKfvPIEEKYPpgfyCGDGDNFVYEDVPILDTWKALEKLVDAGKIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 162 SIGVSNFNYRQLEMILNkpGLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRY---GGWVDQNSPVLLDE 238
Cdd:cd19113 160 SIGVSNFPGALILDLLR--GATIKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYSSFGPQSFvelNQGRALNTPTLFEH 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 126090770 239 PVLGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRY 305
Cdd:cd19113 238 DTIKSIAAKHNKTPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEIAKLDIGLRF 304
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
10-299 |
2.27e-76 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 235.50 E-value: 2.27e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 10 LNDGNFIPVLGFGTalpLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGtVRREDIFYTSKVWCTs 89
Cdd:cd19121 6 LNTGASIPAVGLGT---WQAKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAIAGG-VKREDLFVTTKLWST- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 90 lHPELVRASLERSLQKLQFDYVDLYLIHYPMALKP--GEENFPVDEHGK--LIFDRvDLCATWEAMEKCKDAGLTKSIGV 165
Cdd:cd19121 81 -YHRRVELCLDRSLKSLGLDYVDLYLVHWPVLLNPngNHDLFPTLPDGSrdLDWDW-NHVDTWKQMEKVLKTGKTKAIGV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 166 SNFNYRQLEMILnkPGLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTqryggwvdQNSPVLLDEPVLgSMA 245
Cdd:cd19121 159 SNYSIPYLEELL--KHATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLGS--------TGSPLISDEPVV-EIA 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 126090770 246 KKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFqlSSEDMKVLDGL 299
Cdd:cd19121 228 KKHNVGPGTVLISYQVARGAVVLPKSVTPDRIKSNLEIIDL--DDEDMNKLNDI 279
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
8-300 |
2.47e-76 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 234.25 E-value: 2.47e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 8 VILNDGNFIPVLGFGTalpLECPK-SKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSkiadGTVRREDIFYTSKVW 86
Cdd:cd19126 1 VTLNNGTRMPWLGLGV---FQTPDgDETERAVQTALENGYRSIDTAAIYKNEEGVGEAIRE----SGVPREELFVTTKLW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 87 CTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMAlkpgeenfpvdehGKLIfdrvdlcATWEAMEKCKDAGLTKSIGVS 166
Cdd:cd19126 74 NDDQRARRTEDAFQESLDRLGLDYVDLYLIHWPGK-------------DKFI-------DTWKALEKLYASGKVKAIGVS 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 167 NFNYRQLEMILNKPglKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTqryGGwvdqnspvLLDEPVLGSMAK 246
Cdd:cd19126 134 NFQEHHLEELLAHA--DVVPAVNQVEFHPYLTQKELRGYCKSKGIVVEAWSPLGQ---GG--------LLSNPVLAAIGE 200
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 126090770 247 KYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLN 300
Cdd:cd19126 201 KYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSEDDMTAIDALN 254
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
16-299 |
1.04e-75 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 232.53 E-value: 1.04e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTaLPLEcpKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIrskiADGTVRREDIFYTSKVWCTSLHPELV 95
Cdd:cd19140 8 IPALGLGT-YPLT--GEECTRAVEHALELGYRHIDTAQMYGNEAQVGEAI----AASGVPRDELFLTTKVWPDNYSPDDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 96 RASLERSLQKLQFDYVDLYLIHYPMALkpgeenfpvdehgklifdrVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEM 175
Cdd:cd19140 81 LASVEESLRKLRTDYVDLLLLHWPNKD-------------------VPLAETLGALNEAQEAGLARHIGVSNFTVALLRE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 176 ILNKPGLKYkpVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRyggwvdqnspvLLDEPVLGSMAKKYNRTPALI 255
Cdd:cd19140 142 AVELSEAPL--FTNQVEYHPYLDQRKLLDAAREHGIALTAYSPLARGE-----------VLKDPVLQEIGRKHGKTPAQV 208
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 126090770 256 ALRYQLQR-GIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGL 299
Cdd:cd19140 209 ALRWLLQQeGVAAIPKATNPERLEENLDIFDFTLSDEEMARIAAL 253
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
8-300 |
1.22e-75 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 232.65 E-value: 1.22e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 8 VILNDGNFIPVLGFGTalpLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRskiaDGTVRREDIFYTSKVWC 87
Cdd:cd19131 2 ITLNDGNTIPQLGLGV---WQVSNDEAASAVREALEVGYRSIDTAAIYGNEEGVGKAIR----ASGVPREELFITTKLWN 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 88 TSLHPELVRASLERSLQKLQFDYVDLYLIHYPMalkPGEENFpvdehgklifdrVDlcaTWEAMEKCKDAGLTKSIGVSN 167
Cdd:cd19131 75 SDQGYDSTLRAFDESLRKLGLDYVDLYLIHWPV---PAQDKY------------VE---TWKALIELKKEGRVKSIGVSN 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 168 FNYRQLEMILNKPGLKykPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTqryGGwvdqnspvLLDEPVLGSMAKK 247
Cdd:cd19131 137 FTIEHLQRLIDETGVV--PVVNQIELHPRFQQRELRAFHAKHGIQTESWSPLGQ---GG--------LLSDPVIGEIAEK 203
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 126090770 248 YNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLN 300
Cdd:cd19131 204 HGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAENFDVFDFELDADDMQAIAGLD 256
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
10-301 |
1.66e-74 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 231.23 E-value: 1.66e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 10 LNDGNFIPVLGFGTALPLEcPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWCTs 89
Cdd:cd19119 6 LNTGASIPALGLGTASPHE-DRAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREELFITTKVWPT- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 90 LHPElVRASLERSLQKLQFDYVDLYLIHYPMALK-----PGEENFPVDEHGKLIFDR-VDLCATWEAMEKCKDAGLTKSI 163
Cdd:cd19119 84 FYDE-VERSLDESLKALGLDYVDLLLVHWPVCFEkdsddSGKPFTPVNDDGKTRYAAsGDHITTYKQLEKIYLDGRAKAI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 164 GVSNFNYRQLEMILNKpgLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGgwvdqnspvLLDEPVLGS 243
Cdd:cd19119 163 GVSNYSIVYLERLIKE--CKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGSHGAP---------NLKNPLVKK 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 126090770 244 MAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVfeFQLSSEDMKVLDGLNR 301
Cdd:cd19119 232 IAEKYNVSTGDILISYHVRQGVIVLPKSLKPVRIVSNGKI--VSLTKEDLQKLDDIGE 287
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
10-301 |
5.22e-73 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 226.00 E-value: 5.22e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 10 LNDGNFIPVLGFGTaLPLEcpKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIR-SKIAdgtvrREDIFYTSKVWCT 88
Cdd:cd19132 1 LNDGTQIPAIGFGT-YPLK--GDEGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVRrSGVP-----REELFVTTKLPGR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 89 SLHPELVRASLERSLQKLQFDYVDLYLIHYPMalkpgeenfPvdehgklifdRVDL-CATWEAMEKCKDAGLTKSIGVSN 167
Cdd:cd19132 73 HHGYEEALRTIEESLYRLGLDYVDLYLIHWPN---------P----------SRDLyVEAWQALIEAREEGLVRSIGVSN 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 168 FNYRQLEMILNKPGLKykPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGtqRYGGwvdqnspvLLDEPVLGSMAKK 247
Cdd:cd19132 134 FLPEHLDRLIDETGVT--PAVNQIELHPYFPQAEQRAYHREHGIVTQSWSPLG--RGSG--------LLDEPVIKAIAEK 201
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 126090770 248 YNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNR 301
Cdd:cd19132 202 HGKTPAQVVLRWHVQLGVVPIPKSANPERQRENLAIFDFELSDEDMAAIAALDR 255
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
17-299 |
6.88e-73 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 226.25 E-value: 6.88e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 17 PVLGFGTALpleCPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWCTSLHPELVR 96
Cdd:cd19128 2 PRLGFGTYK---ITESESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDLFITSKLWPTMHQPENVK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 97 ASLERSLQKLQFDYVDLYLIHYPMALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMI 176
Cdd:cd19128 79 EQLLITLQDLQLEYLDLFLIHWPLAFDMDTDGDPRDDNQIQSLSKKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 177 LNKpgLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLgtqryGGWVDQNSPVLLDEPVLGSMAKKYNRTPALIA 256
Cdd:cd19128 159 LNY--CKIKPFMNQIECHPYFQNDKLIKFCIENNIHVTAYRPL-----GGSYGDGNLTFLNDSELKALATKYNTTPPQVI 231
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 126090770 257 LRYQLQR---GIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGL 299
Cdd:cd19128 232 IAWHLQKwpkNYSVIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
4-299 |
2.27e-72 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 224.51 E-value: 2.27e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 4 KCHCVILNDGNFIPVLGFGTalplecpkSK----AKELTKIAI-DAGFHHFDSASVYNTEDHVGEAIRskiADGtVRRED 78
Cdd:cd19135 1 GTPTVRLSNGVEMPILGLGT--------SHsggySHEAVVYALkECGYRHIDTAKRYGCEELLGKAIK---ESG-VPRED 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 79 IFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENfpvdehgklifdRVDLCATWEAMEKCKDAG 158
Cdd:cd19135 69 LFLTTKLWPSDYGYESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSGKNV------------KETRAETWRALEELYDEG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 159 LTKSIGVSNFNYRQLEMILNKPGLKykPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYggwvdqnspvlLDE 238
Cdd:cd19135 137 LCRAIGVSNFLIEHLEQLLEDCSVV--PHVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLAKGKA-----------LEE 203
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126090770 239 PVLGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGL 299
Cdd:cd19135 204 PTVTELAKKYQKTPAQILIRWSIQNGVVTIPKSTKEERIKENCQVFDFSLSEEDMATLDSL 264
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
8-305 |
4.04e-72 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 225.38 E-value: 4.04e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 8 VILNDGNFIPVLGFGTalpLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWC 87
Cdd:cd19115 5 VKLNSGYDMPLVGFGL---WKVNNDTCADQVYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDLFIVSKLWN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 88 TSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALK---PgEENFP---VDEHGKLIFDRVDLCATWEAMEKCKDAGLTK 161
Cdd:cd19115 82 TFHDGERVEPICRKQLADWGIDYFDLFLIHFPIALKyvdP-AVRYPpgwFYDGKKVEFSNAPIQETWTAMEKLVDKGLAR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 162 SIGVSNFNyRQLEMILnkpgLKY---KPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQrygGWVD------QNS 232
Cdd:cd19115 161 SIGVSNFS-AQLLMDL----LRYariRPATLQIEHHPYLTQPRLVKYAQKEGIAVTAYSSFGPQ---SFLEldlpgaKDT 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126090770 233 PVLLDEPVLGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRY 305
Cdd:cd19115 233 PPLFEHDVIKSIAEKHGKTPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLRF 305
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
8-307 |
1.21e-71 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 222.78 E-value: 1.21e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 8 VILNDGNFIPVLGFGTALPLEcpKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKiadgTVRREDIFYTSKVWC 87
Cdd:cd19156 1 VKLANGVEMPRLGLGVWRVQD--GAEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIRES----GVPREEVFVTTKLWN 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 88 TSLHPELVRASLERSLQKLQFDYVDLYLIHYPMAlkpgeenfpvdehGKLIfdrvdlcATWEAMEKCKDAGLTKSIGVSN 167
Cdd:cd19156 75 SDQGYESTLAAFEESLEKLGLDYVDLYLIHWPVK-------------GKFK-------DTWKAFEKLYKEKKVRAIGVSN 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 168 FNYRQLEMILNKpgLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRyggwvdqnspvLLDEPVLGSMAKK 247
Cdd:cd19156 135 FHEHHLEELLKS--CKVAPMVNQIELHPLLTQEPLRKFCKEKNIAVEAWSPLGQGK-----------LLSNPVLKAIGKK 201
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 248 YNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRYIP 307
Cdd:cd19156 202 YGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDVFDFELTAEEIRQIDGLNTDHRYGP 261
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
13-305 |
6.65e-68 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 214.34 E-value: 6.65e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 13 GNFIPVLGFGTAlplecpKSKAKELTKI---AIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWCTS 89
Cdd:cd19114 1 GDKMPLVGFGTA------KIKANETEEViynAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKREDLFIVTKLWNNF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 90 LHPELVRASLERSLQKLQFDYVDLYLIHYPMALK---PGEENFPVDEHG---KLIFDRVDLCATWEAMEKCKDAGLTKSI 163
Cdd:cd19114 75 HGKDHVREAFDRQLKDYGLDYIDLYLIHFPIPAAyvdPAENYPFLWKDKelkKFPLEQSPMQECWREMEKLVDAGLVRNI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 164 GVSNFNyrqLEMILNKpgLKY---KPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPV--LLDE 238
Cdd:cd19114 155 GIANFN---VQLILDL--LTYakiKPAVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSFGNAVYTKVTKHLKHFtnLLEH 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 126090770 239 PVLGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRY 305
Cdd:cd19114 230 PVVKKLADKHKRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELEANARF 296
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
8-300 |
1.98e-66 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 209.00 E-value: 1.98e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 8 VILNDGNFIPVLGFGTalpLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIrskiADGTVRREDIFYTSKVWC 87
Cdd:cd19130 2 IVLNDGNSIPQLGYGV---FKVPPADTQRAVATALEVGYRHIDTAAIYGNEEGVGAAI----AASGIPRDELFVTTKLWN 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 88 TSLHPELVRASLERSLQKLQFDYVDLYLIHYPMalkPGEENFpvdehgklifdrvdlCATWEAMEKCKDAGLTKSIGVSN 167
Cdd:cd19130 75 DRHDGDEPAAAFAESLAKLGLDQVDLYLVHWPT---PAAGNY---------------VHTWEAMIELRAAGRTRSIGVSN 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 168 FNYRQLEMILNKPGLKykPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGtqryggwvdQNSpvLLDEPVLGSMAKK 247
Cdd:cd19130 137 FLPPHLERIVAATGVV--PAVNQIELHPAYQQRTIRDWAQAHDVKIEAWSPLG---------QGK--LLGDPPVGAIAAA 203
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 126090770 248 YNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLN 300
Cdd:cd19130 204 HGKTPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDVFDFDLTDTEIAAIDALD 256
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
8-300 |
3.70e-66 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 208.80 E-value: 3.70e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 8 VILNDGNFIPVLGFGT-ALPlecPKSKAKELTKiAIDAGFHHFDSASVYNTEDHVGEAIRSKiadgTVRREDIFYTSKVW 86
Cdd:cd19127 1 ITLNNGVEMPALGLGVfQTP---PEETADAVAT-ALADGYRLIDTAAAYGNEREVGEGIRRS----GVDRSDIFVTTKLW 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 87 CTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMalkpgeenfpvdehgKLIFDRVdlCATWEAMEKCKDAGLTKSIGVS 166
Cdd:cd19127 73 ISDYGYDKALRGFDASLRRLGLDYVDLYLLHWPV---------------PNDFDRT--IQAYKALEKLLAEGRVRAIGVS 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 167 NFNYRQLEMILNKPGLKykPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLG-TQRYGGWVDQNSPVLLDEPVLGSMA 245
Cdd:cd19127 136 NFTPEHLERLIDATTVV--PAVNQVELHPYFSQKDLRAFHRRLGIVTQAWSPIGgVMRYGASGPTGPGDVLQDPTITGLA 213
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 126090770 246 KKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLN 300
Cdd:cd19127 214 EKYGKTPAQIVLRWHLQNGVSAIPKSVHPERIAENIDIFDFALSAEDMAAIDALD 268
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
8-305 |
1.38e-65 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 207.40 E-value: 1.38e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 8 VILNDGNFIPVLGFGTAlplECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRskiADGtVRREDIFYTSKVWC 87
Cdd:cd19134 3 VTLNDDNTMPVIGLGVG---ELSDDEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIA---ASG-IPRGELFVTTKLAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 88 TSLHPELVRASLERSLQKLQFDYVDLYLIHYPMAlkpgeenfpvdEHGKLifdrVDlcaTWEAMEKCKDAGLTKSIGVSN 167
Cdd:cd19134 76 PDQGFTASQAACRASLERLGLDYVDLYLIHWPAG-----------REGKY----VD---SWGGLMKLREEGLARSIGVSN 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 168 FNYRQLEMILNKPGlkYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRyggwvdqnspvLLDEPVLGSMAKK 247
Cdd:cd19134 138 FTAEHLENLIDLTF--FTPAVNQIELHPLLNQAELRKVNAQHGIVTQAYSPLGVGR-----------LLDNPAVTAIAAA 204
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 126090770 248 YNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRY 305
Cdd:cd19134 205 HGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELTADHMDALDGLDDGTRF 262
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
16-299 |
1.55e-64 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 204.12 E-value: 1.55e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGT--ALPLECPKSkakelTKIAIDAGFHHFDSASVYNTEDHVGEAIrskiADGTVRREDIFYTSKVWCTSLHPE 93
Cdd:cd19139 1 IPAFGLGTfrLKDDVVIDS-----VRTALELGYRHIDTAQIYDNEAAVGQAI----AESGVPRDELFITTKIWIDNLSKD 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 94 LVRASLERSLQKLQFDYVDLYLIHYPMalkpgeenfpvdehgklIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQL 173
Cdd:cd19139 72 KLLPSLEESLEKLRTDYVDLTLIHWPS-----------------PNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 174 EMILNKPGlKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGtqrYGgwvdqnspVLLDEPVLGSMAKKYNRTPA 253
Cdd:cd19139 135 DEAIAVVG-AGAIATNQIELSPYLQNRKLVAHCKQHGIHVTSYMTLA---YG--------KVLDDPVLAAIAERHGATPA 202
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 126090770 254 LIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGL 299
Cdd:cd19139 203 QIALAWAMARGYAVIPSSTKREHLRSNLLALDLTLDADDMAAIAAL 248
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
19-300 |
8.77e-64 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 203.31 E-value: 8.77e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 19 LGFGTA----LPLECPKSKAKELTKIAIDAGFHHFDSASVYNT---EDHVGEAIrskiADGTVRREDIFYTSKV------ 85
Cdd:pfam00248 1 IGLGTWqlggGWGPISKEEALEALRAALEAGINFIDTAEVYGDgksEELLGEAL----KDYPVKRDKVVIATKVpdgdgp 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 86 WCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPmalkpgEENFPVDEhgklifdrvdlcaTWEAMEKCKDAGLTKSIGV 165
Cdd:pfam00248 77 WPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWP------DPDTPIEE-------------TWDALEELKKEGKIRAIGV 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 166 SNFNYRQLEMILNKPglKYKPVCNQVECHPY--LNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPV--- 240
Cdd:pfam00248 138 SNFDAEQIEKALTKG--KIPIVAVQVEYNLLrrRQEEELLEYCKKNGIPLIAYSPLGGGLLTGKYTRDPDKGPGERRrll 215
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126090770 241 -------------LGSMAKKYNRTPALIALRYQLQR---GIVVLNTSlKEERIKENMQVFEFQLSSEDMKVLDGLN 300
Cdd:pfam00248 216 kkgtplnlealeaLEEIAKEHGVSPAQVALRWALSKpgvTIPIPGAS-NPEQLEDNLGALEFPLSDEEVARIDELL 290
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
13-297 |
7.54e-60 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 192.44 E-value: 7.54e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 13 GNFIPVLGFGT---ALPLECPKS---KAKELTKIAIDAGFHHFDSASVYN---TEDHVGEAIRskiadgTVRREDIFYTS 83
Cdd:cd19072 1 GEEVPVLGLGTwgiGGGMSKDYSddkKAIEALRYAIELGINLIDTAEMYGgghAEELVGKAIK------GFDREDLFITT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 84 KVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPmalkpgeeNfpvdehgklifDRVDLCATWEAMEKCKDAGLTKSI 163
Cdd:cd19072 75 KVSPDHLKYDDVIKAAKESLKRLGTDYIDLYLIHWP--------N-----------PSIPIEETLRAMEELVEEGKIRYI 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 164 GVSNFNYRQLEMILNKPGlKYKPVCNQVECHpYLNQ---MKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQnspvlldePV 240
Cdd:cd19072 136 GVSNFSLEELEEAQSYLK-KGPIVANQVEYN-LFDReeeSGLLPYCQKNGIAIIAYSPLEKGKLSNAKGS--------PL 205
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 126090770 241 LGSMAKKYNRTPALIALRYQLQR-GIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19072 206 LDEIAKKYGKTPAQIALNWLISKpNVIAIPKASNIEHLEENAGALGWELSEEDLQRLD 263
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
10-297 |
1.86e-57 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 187.44 E-value: 1.86e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 10 LNDGNFIPVLGFGTaLPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADG-TVRREDIFYTSKVWcT 88
Cdd:cd19122 3 LNNGVKIPAVGFGT-FANEGAKGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLKENpSVKREDLFICTKVW-N 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 89 SLH-PELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENFP-VDEHGKLIFDRvDLC----ATWEAMEKCKDAGLTKS 162
Cdd:cd19122 81 HLHePEDVKWSIDNSLKNLKLDYIDLFLVHWPIAAEKNDQRSPkLGPDGKYVILK-DLTenpePTWRAMEEIYESGKAKA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 163 IGVSNFNYRQLEMILNKPglKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYggwVDQNSPVLLDEPVLG 242
Cdd:cd19122 160 IGVSNWTIPGLKKLLSFA--KVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLGSQNQ---VPSTGERVSENPTLN 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 126090770 243 SMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEfqLSSEDMKVLD 297
Cdd:cd19122 235 EVAEKGGYSLAQVLIAWGLRRGYVVLPKSSTPSRIESNFKSIE--LSDEDFEAIN 287
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
10-293 |
7.58e-56 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 182.58 E-value: 7.58e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 10 LNDGNFIPVLGFGTalpLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSkiadGTVRREDIFYTSKVWCTS 89
Cdd:PRK11565 9 LQDGNVMPQLGLGV---WQASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKE----ASVAREELFITTKLWNDD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 90 -LHPelvRASLERSLQKLQFDYVDLYLIHYPMalkPGEENFpvdehgklifdrVDlcaTWEAMEKCKDAGLTKSIGVSNF 168
Cdd:PRK11565 82 hKRP---REALEESLKKLQLDYVDLYLMHWPV---PAIDHY------------VE---AWKGMIELQKEGLIKSIGVCNF 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 169 NYRQLEMILNKPGLKykPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGtqryggwvdQNSPVLLDEPVLGSMAKKY 248
Cdd:PRK11565 141 QIHHLQRLIDETGVT--PVINQIELHPLMQQRQLHAWNATHKIQTESWSPLA---------QGGKGVFDQKVIRDLADKY 209
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 126090770 249 NRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDM 293
Cdd:PRK11565 210 GKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDEL 254
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
39-317 |
2.31e-55 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 180.99 E-value: 2.31e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 39 KIAIDAGFHHFDSASVYNTEDHVGEAIrskiADGTVRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHY 118
Cdd:PRK11172 23 KTALELGYRAIDTAQIYDNEAAVGQAI----AESGVPRDELFITTKIWIDNLAKDKLIPSLKESLQKLRTDYVDLTLIHW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 119 PmalKPGeenfpvdehgklifDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKPGlKYKPVCNQVECHPYLN 198
Cdd:PRK11172 99 P---SPN--------------DEVSVEEFMQALLEAKKQGLTREIGISNFTIALMKQAIAAVG-AENIATNQIELSPYLQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 199 QMKLLDFCKSKDIVLVAYGVLGtqrYGGwvdqnspvLLDEPVLGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIK 278
Cdd:PRK11172 161 NRKVVAFAKEHGIHVTSYMTLA---YGK--------VLKDPVIARIAAKHNATPAQVILAWAMQLGYSVIPSSTKRENLA 229
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 126090770 279 ENMQVFEFQLSSEDMKVLDGLNRNMRYI-PAAIfkgHPNW 317
Cdd:PRK11172 230 SNLLAQDLQLDAEDMAAIAALDRNGRLVsPEGL---APEW 266
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
6-297 |
5.57e-50 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 167.04 E-value: 5.57e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 6 HCVILNDGNFIPVLGFGTALPLECPKSKAKELTKI--AIDAGFHHFDSASVYN---TEDHVGEAIRSkiadgtvRREDIF 80
Cdd:cd19138 1 RTVTLPDGTKVPALGQGTWYMGEDPAKRAQEIEALraGIDLGMTLIDTAEMYGdggSEELVGEAIRG-------RRDKVF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 81 YTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPmalkpgeenfpvdehgklifDRVDLCATWEAMEKCKDAGLT 160
Cdd:cd19138 74 LVSKVLPSNASRQGTVRACERSLRRLGTDYLDLYLLHWR--------------------GGVPLAETVAAMEELKKEGKI 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 161 KSIGVSNFNYRQLEMILNKPGLKyKPVCNQVECHpyLNQ----MKLLDFCKSKDIVLVAYGVLGTqryGGWVDQnspVLL 236
Cdd:cd19138 134 RAWGVSNFDTDDMEELWAVPGGG-NCAANQVLYN--LGSrgieYDLLPWCREHGVPVMAYSPLAQ---GGLLRR---GLL 204
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 126090770 237 DEPVLGSMAKKYNRTPALIALRYQLQRGIVV-LNTSLKEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19138 205 ENPTLKEIAARHGATPAQVALAWVLRDGNVIaIPKSGSPEHARENAAAADLELTEEDLAELD 266
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
13-297 |
2.26e-46 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 157.73 E-value: 2.26e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 13 GNFIPVLGFGT------ALPLECPKSKAKELTKIAIDAGFHHFDSASVY---NTEDHVGEAIRSkiadgtVRREDIFYTS 83
Cdd:cd19137 1 GEKIPALGLGTwgiggfLTPDYSRDEEMVELLKTAIELGYTHIDTAEMYgggHTEELVGKAIKD------FPREDLFIVT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 84 KVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPmalkpgEENFPVDEhgklifdrvdlcaTWEAMEKCKDAGLTKSI 163
Cdd:cd19137 75 KVWPTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWP------NPNIPLEE-------------TLSAMAEGVRQGLIRYI 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 164 GVSNFNYRQLEMILNKpgLKYKPVCNQVECHPY---LNQMKLLDFCKSKDIVLVAYGVLgtqryggwvdqNSPVLLDEPV 240
Cdd:cd19137 136 GVSNFNRRLLEEAISK--SQTPIVCNQVKYNLEdrdPERDGLLEYCQKNGITVVAYSPL-----------RRGLEKTNRT 202
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 126090770 241 LGSMAKKYNRTPALIALRYQLQR-GIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19137 203 LEEIAKNYGKTIAQIALAWLIQKpNVVAIPKAGRVEHLKENLKATEIKLSEEEMKLLD 260
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
34-297 |
1.32e-38 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 138.13 E-value: 1.32e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 34 AKELTKIAIDAGFHHFDSASVY---NTEDHVGEAIRskiadGTVRREDIFYTSKVWCT--SLHPELVRASLERSLQKLQF 108
Cdd:cd19093 28 LQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFLK-----ELGDRDEVVIATKFAPLpwRLTRRSVVKALKASLERLGL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 109 DYVDLYLIHYPMALKPGeenfpvdehgklifdrvdLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMI---LNKPGlkYK 185
Cdd:cd19093 103 DSIDLYQLHWPGPWYSQ------------------IEALMDGLADAVEEGLVRAVGVSNYSADQLRRAhkaLKERG--VP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 186 PVCNQVE---CHPYLNQMKLLDFCKSKDIVLVAY-----GVLgTQRY-------GGWVDQNSPVLLDE--PV---LGSMA 245
Cdd:cd19093 163 LASNQVEyslLYRDPEQNGLLPACDELGITLIAYsplaqGLL-TGKYspenpppGGRRRLFGRKNLEKvqPLldaLEEIA 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 126090770 246 KKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19093 242 EKYGKTPAQVALNWLIAKGVVPIPGAKNAEQAEENAGALGWRLSEEEVAELD 293
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
16-297 |
1.64e-38 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 138.39 E-value: 1.64e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTA----LPLECPKSKAKELTKIAIDAGFHHFDSASVYN---TEDHVGEAIRSKiadgtvRREDIFYTSKV--- 85
Cdd:COG0667 13 VSRLGLGTMtfggPWGGVDEAEAIAILDAALDAGINFFDTADVYGpgrSEELLGEALKGR------PRDDVVIATKVgrr 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 86 -----WCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPmalkpgEENFPVDEhgklifdrvdlcaTWEAMEKCKDAGLT 160
Cdd:COG0667 87 mgpgpNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRP------DPDTPIEE-------------TLGALDELVREGKI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 161 KSIGVSNFNYRQLEMILNKPGLKYKPVCNQVEchpY--LNQ---MKLLDFCKSKDIVLVAYGVLG----TQRY--GGWVD 229
Cdd:COG0667 148 RYIGVSNYSAEQLRRALAIAEGLPPIVAVQNE---YslLDRsaeEELLPAARELGVGVLAYSPLAggllTGKYrrGATFP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 230 QNS--------PVLLDE-----PVLGSMAKKYNRTPALIALRYQLQRG---IVVLNTSlKEERIKENMQVFEFQLSSEDM 293
Cdd:COG0667 225 EGDraatnfvqGYLTERnlalvDALRAIAAEHGVTPAQLALAWLLAQPgvtSVIPGAR-SPEQLEENLAAADLELSAEDL 303
|
....
gi 126090770 294 KVLD 297
Cdd:COG0667 304 AALD 307
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
41-297 |
1.49e-37 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 135.41 E-value: 1.49e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 41 AIDAGFHHFDSASVYN---TEDHVGEAIRSkiadgtvRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIH 117
Cdd:cd19085 32 ALDAGINFFDTAEAYGdghSEEVLGKALKG-------RRDDVVIATKVSPDNLTPEDVRKSCERSLKRLGTDYIDLYQIH 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 118 YPMALKPGEENFpvdehgklifdrvdlcatwEAMEKCKDAGLTKSIGVSNFNYRQLEMILnKPGlkyKPVCNQVechPYl 197
Cdd:cd19085 105 WPSSDVPLEETM-------------------EALEKLKEEGKIRAIGVSNFGPAQLEEAL-DAG---RIDSNQL---PY- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 198 NQM------KLLDFCKSKDIVLVAYGVLG----TQRYGGwVDQNSP-------VLLDEP-----------VLGSMAKKYN 249
Cdd:cd19085 158 NLLwraieyEILPFCREHGIGVLAYSPLAqgllTGKFSS-AEDFPPgdartrlFRHFEPgaeeetfealeKLKEIADELG 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 126090770 250 RTPALIALRYQLQRGIV--VLNTSLKEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19085 237 VTMAQLALAWVLQQPGVtsVIVGARNPEQLEENAAAVDLELSPSVLERLD 286
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
16-297 |
1.43e-36 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 133.03 E-value: 1.43e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTAlPL------ECPKSKAKELTKIAIDAGFHHFDSASVY---NTEDHVGEAIRSkiadgtvRREDIFYTSKV- 85
Cdd:cd19084 4 VSRIGLGTW-AIggtwwgEVDDQESIEAIKAAIDLGINFFDTAPVYgfgHSEEILGKALKG-------RRDDVVIATKCg 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 86 --W------CTSLHPELVRASLERSLQKLQFDYVDLYLIHYPmalkpgEENFPVDEhgklifdrvdlcaTWEAMEKCKDA 157
Cdd:cd19084 76 lrWdggkgvTKDLSPESIRKEVEQSLRRLQTDYIDLYQIHWP------DPNTPIEE-------------TAEALEKLKKE 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 158 GLTKSIGVSNFNYRQLEMIlnkpgLKY-KPVCNQVechPY--LNQ---MKLLDFCKSKDIVLVAYGVLG----TQRY--- 224
Cdd:cd19084 137 GKIRYIGVSNFSVEQLEEA-----RKYgPIVSLQP---PYsmLEReieEELLPYCRENGIGVLPYGPLAqgllTGKYkke 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 225 -----GGWvdQNSPVLLDEP----------VLGSMAKKYNRTPALIALRYQLQR--GIVVLNTSLKEERIKENMQVFEFQ 287
Cdd:cd19084 209 ptfppDDR--RSRFPFFRGEnfeknleivdKLKEIAEKYGKSLAQLAIAWTLAQpgVTSAIVGAKNPEQLEENAGALDWE 286
|
330
....*....|
gi 126090770 288 LSSEDMKVLD 297
Cdd:cd19084 287 LTEEELKEID 296
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
17-282 |
7.82e-33 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 121.47 E-value: 7.82e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 17 PVLGFGTA-LPLECPKSKAKELTKIAIDAGFHHFDSASVYNT---EDHVGEAIRSKiadgtVRREDIFYTSKVWCT---- 88
Cdd:cd06660 1 SRLGLGTMtFGGDGDEEEAFALLDAALEAGGNFFDTADVYGDgrsERLLGRWLKGR-----GNRDDVVIATKGGHPpggd 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 89 ----SLHPELVRASLERSLQKLQFDYVDLYLIHYPmalkpgEENFPVDEhgklifdrvdlcaTWEAMEKCKDAGLTKSIG 164
Cdd:cd06660 76 psrsRLSPEHIRRDLEESLRRLGTDYIDLYYLHRD------DPSTPVEE-------------TLEALNELVREGKIRYIG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 165 VSNFNYRQLEMILN--KPGLKYKPVCNQVE---CHPYLNQMKLLDFCKSKDIVLVAYGVLGtqryGGwvdqnspvlldep 239
Cdd:cd06660 137 VSNWSAERLAEALAyaKAHGLPGFAAVQPQyslLDRSPMEEELLDWAEENGLPLLAYSPLA----RG------------- 199
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 126090770 240 vlgsmakkynrtPALIALRYQLQR---GIVVLNTSlKEERIKENMQ 282
Cdd:cd06660 200 ------------PAQLALAWLLSQpfvTVPIVGAR-SPEQLEENLA 232
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
18-292 |
3.82e-30 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 115.73 E-value: 3.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 18 VLGFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYNT---EDHVGEAIRSKiadgTVRREDIFYTSKvwC------- 87
Cdd:cd19092 10 VLGCMRLADWGESAEELLSLIEAALELGITTFDHADIYGGgkcEELFGEALALN----PGLREKIEIQTK--Cgirlgdd 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 88 ----------TSlhPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEEnfpvdehgklifdrvdlcaTWEAMEKCKDA 157
Cdd:cd19092 84 prpgrikhydTS--KEHILASVEGSLKRLGTDYLDLLLLHRPDPLMDPEE-------------------VAEAFDELVKS 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 158 GLTKSIGVSNFNYRQLEMiLNKpGLKYKPVCNQVECHPYLNQM---KLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPV 234
Cdd:cd19092 143 GKVRYFGVSNFTPSQIEL-LQS-YLDQPLVTNQIELSLLHTEAiddGTLDYCQLLDITPMAWSPLGGGRLFGGFDERFQR 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126090770 235 LLDepVLGSMAKKYNRTPALIALRYQLQ---RGIVVLNTsLKEERIKENMQVFEFQLSSED 292
Cdd:cd19092 221 LRA--ALEELAEEYGVTIEAIALAWLLRhpaRIQPILGT-TNPERIRSAVKALDIELTREE 278
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
31-292 |
1.86e-29 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 114.09 E-value: 1.86e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 31 KSKAKELTKIAIDAGFHHFDSASVYN---TEDHVGEAIRSKiadgTVRREDIFYTSKvwC-----------------TSl 90
Cdd:COG4989 30 PAEAAALIEAALELGITTFDHADIYGgytCEALFGEALKLS----PSLREKIELQTK--CgirlpseardnrvkhydTS- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 91 hPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEEnfpvdehgklifdrvdlcaTWEAMEKCKDAGLTKSIGVSNFNY 170
Cdd:COG4989 103 -KEHIIASVEGSLRRLGTDYLDLLLLHRPDPLMDPEE-------------------VAEAFDELKASGKVRHFGVSNFTP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 171 RQLEMiLNKpGLKYKPVCNQVECHPYLNQM---KLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDepVLGSMAKK 247
Cdd:COG4989 163 SQFEL-LQS-ALDQPLVTNQIELSLLHTDAfddGTLDYCQLNGITPMAWSPLAGGRLFGGFDEQFPRLRA--ALDELAEK 238
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 126090770 248 YNRTPALIALRYqLQR---GIVVLNTSLKEERIKENMQVFEFQLSSED 292
Cdd:COG4989 239 YGVSPEAIALAW-LLRhpaGIQPVIGTTNPERIKAAAAALDIELTREE 285
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
35-299 |
1.17e-26 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 106.73 E-value: 1.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 35 KELTKIAIDAGFHHFDSASVYNT---EDHVGEAIRSKiadgtvRREDIFYTSKvwctSLH------------PELVRASL 99
Cdd:cd19083 36 KDLVREALDNGVNLLDTAFIYGLgrsEELVGEVLKEY------NRNEVVIATK----GAHkfggdgsvlnnsPEFLRSAV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 100 ERSLQKLQFDYVDLYLIHYPmalkpgEENFPVDEhgklifdrvdlcaTWEAMEKCKDAGLTKSIGVSNFNYRQLEMiLNK 179
Cdd:cd19083 106 EKSLKRLNTDYIDLYYIHFP------DGETPKAE-------------AVGALQELKDEGKIRAIGVSNFSLEQLKE-ANK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 180 PGL------KYKPVCNQVECHpylnqmkLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSpVLLDEPV------------- 240
Cdd:cd19083 166 DGYvdvlqgEYNLLQREAEED-------ILPYCVENNISFIPYFPLASGLLAGKYTKDT-KFPDNDLrndkplfkgerfs 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126090770 241 --------LGSMAKKYNRTPALIALRYQLQR-GI-VVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGL 299
Cdd:cd19083 238 enldkvdkLKSIADEKGVTVAHLALAWYLTRpAIdVVIPGAKRAEQVIDNLKALDVTLTEEEIAFIDAL 306
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
16-166 |
3.42e-25 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 101.02 E-value: 3.42e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVY-NTEDHVGEAIRSkiadgtvRREDIFYTSKVWCTSlhPEL 94
Cdd:cd19100 11 VSRLGFGGGPLGRLSQEEAAAIIRRALDLGINYFDTAPSYgDSEEKIGKALKG-------RRDKVFLATKTGARD--YEG 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 126090770 95 VRASLERSLQKLQFDYVDLYLIHYPMALKPGEENFpvDEHGklifdrvdlcaTWEAMEKCKDAGLTKSIGVS 166
Cdd:cd19100 82 AKRDLERSLKRLGTDYIDLYQLHAVDTEEDLDQVF--GPGG-----------ALEALLEAKEEGKIRFIGIS 140
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
16-304 |
2.80e-24 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 101.05 E-value: 2.80e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGtALPL-ECPKSKAKELTKIAIDAGFHHFDSASVY-NTEDHVGEAIRSkiadgtvRREDIFYTSK--VWCTSlh 91
Cdd:COG1453 13 VSVLGFG-GMRLpRKDEEEAEALIRRAIDNGINYIDTARGYgDSEEFLGKALKG-------PRDKVILATKlpPWVRD-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 92 PELVRASLERSLQKLQFDYVDLYLIHYPMalKPGEENFPVDEHGklifdrvdlcaTWEAMEKCKDAGLTKSIGVSNFNyr 171
Cdd:COG1453 83 PEDMRKDLEESLKRLQTDYIDLYLIHGLN--TEEDLEKVLKPGG-----------ALEALEKAKAEGKIRHIGFSTHG-- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 172 QLEMILnkpglkykpvcNQVECHP---------YLNQ-----MKLLDFCKSKDIVLVAYGVLGtqryGGWVDQNSPVLLD 237
Cdd:COG1453 148 SLEVIK-----------EAIDTGDfdfvqlqynYLDQdnqagEEALEAAAEKGIGVIIMKPLK----GGRLANPPEKLVE 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126090770 238 EpvlgsmaKKYNRTPALIALRYQLQR-GIVVLNTSL-KEERIKENMQVFE--FQLSSEDMKVLDGLNRNMR 304
Cdd:COG1453 213 L-------LCPPLSPAEWALRFLLSHpEVTTVLSGMsTPEQLDENLKTADnlEPLTEEELAILERLAEELG 276
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
11-297 |
5.09e-24 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 99.61 E-value: 5.09e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 11 NDGNFIPVLGFGTAL--PLECPKSK--------AKELTKIAIDAGFHHFDSASVYN---TEDHVGEAIRSkiadgtvRRE 77
Cdd:cd19091 8 RSGLKVSELALGTMTfgGGGGFFGAwggvdqeeADRLVDIALDAGINFFDTADVYSegeSEEILGKALKG-------RRD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 78 DIFYTSKVWC----------TSLHpELVRAsLERSLQKLQFDYVDLYLIHYPMALKPGEEnfpvdehgklifdrvdlcaT 147
Cdd:cd19091 81 DVLIATKVRGrmgegpndvgLSRH-HIIRA-VEASLKRLGTDYIDLYQLHGFDALTPLEE-------------------T 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 148 WEAMEKCKDAGLTKSIGVSNFNYRQLEMIL---NKPGLKyKPVCNQVechpYLN------QMKLLDFCKSKDIVLVAYGV 218
Cdd:cd19091 140 LRALDDLVRQGKVRYIGVSNFSAWQIMKALgisERRGLA-RFVALQA----YYSllgrdlEHELMPLALDQGVGLLVWSP 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 219 LG----------------TQRYGGWVDQNSPVllDEP-------VLGSMAKKYNRTPALIALRYQLQRGIVvlnTSL--- 272
Cdd:cd19091 215 LAggllsgkyrrgqpapeGSRLRRTGFDFPPV--DRErgydvvdALREIAKETGATPAQVALAWLLSRPTV---SSViig 289
|
330 340
....*....|....*....|....*..
gi 126090770 273 --KEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19091 290 arNEEQLEDNLGAAGLSLTPEEIARLD 316
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
42-297 |
2.63e-23 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 97.67 E-value: 2.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 42 IDAGFHHFDSASVY-NTEDHVGEAIRSKIADGTVRREDIFYTSkvWCTSLH-----PELVRASLERSLQKLQFDYVDLYL 115
Cdd:cd19101 33 VDAGLTTFDCADIYgPAEELIGEFRKRLRRERDAADDVQIHTK--WVPDPGeltmtRAYVEAAIDRSLKRLGVDRLDLVQ 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 116 IH---YpmalkpGEENFpvdehgklifdrVDlcaTWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKPglkYKPVCNQVE 192
Cdd:cd19101 111 FHwwdY------SDPGY------------LD---AAKHLAELQEEGKIRHLGLTNFDTERLREILDAG---VPIVSNQVQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 193 cHPYLNQ---MKLLDFCKSKDIVLVAYGVLGtqryGG-----WVDQNSP--------------VLLDE-----------P 239
Cdd:cd19101 167 -YSLLDRrpeNGMAALCEDHGIKLLAYGTLA----GGllsekYLGVPEPtgpaletrslqkykLMIDEwggwdlfqellR 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126090770 240 VLGSMAKKYNRTPALIALRYQLQR---GIVVLNTSLkEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19101 242 TLKAIADKHGVSIANVAVRWVLDQpgvAGVIVGARN-SEHIDDNVRAFSFRLDDEDRAAID 301
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
16-289 |
2.40e-22 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 93.82 E-value: 2.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGtALPLECP--------KSKAKELTKIAIDAGFHHFDSASVYN---TEDHVGEAIRSKIAD-------GTVRRE 77
Cdd:cd19088 1 VSRLGYG-AMRLTGPgiwgppadREEAIAVLRRALELGVNFIDTADSYGpdvNERLIAEALHPYPDDvviatkgGLVRTG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 78 DifytsKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENFpvdehgklifdrvdlcatwEAMEKCKDA 157
Cdd:cd19088 80 P-----GWWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQL-------------------GALAELQDE 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 158 GLTKSIGVSNFNYRQLEMILNKPGLkykpVCNQVECHPYLNQ-MKLLDFCKSKDIVLVAYGVLGtqryGGwvdqnsPVLL 236
Cdd:cd19088 136 GLIRHIGLSNVTVAQIEEARAIVRI----VSVQNRYNLANRDdEGVLDYCEAAGIAFIPWFPLG----GG------DLAQ 201
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 126090770 237 DEPVLGSMAKKYNRTPALIALRYQLQRG--IVVLNTSLKEERIKENMQVFEFQLS 289
Cdd:cd19088 202 PGGLLAEVAARLGATPAQVALAWLLARSpvMLPIPGTSSVEHLEENLAAAGLRLS 256
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
17-169 |
3.40e-22 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 93.45 E-value: 3.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 17 PVLGFGTA----LPLECPKSKAKELTKIAIDAGFHHFDSASVY-NTEDHVGEAIRskiadgTVRREDIFYTSKVWCTSLH 91
Cdd:cd19095 1 SVLGLGTSgigrVWGVPSEAEAARLLNTALDLGINLIDTAPAYgRSEERLGRALA------GLRRDDLFIATKVGTHGEG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 92 --------PELVRASLERSLQKLQFDYVDLYLIHYPMalkpgeenfPVDEHGKLIfdrvdlcatwEAMEKCKDAGLTKSI 163
Cdd:cd19095 75 grdrkdfsPAAIRASIERSLRRLGTDYIDLLQLHGPS---------DDELTGEVL----------ETLEDLKAAGKVRYI 135
|
....*.
gi 126090770 164 GVSNFN 169
Cdd:cd19095 136 GVSGDG 141
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
16-229 |
1.28e-21 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 91.88 E-value: 1.28e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTA-LPLECPkskakELTKIAIDAGFHHFDSASVY---NTEDHVGEAIRskiadgTVRREDIFYTSKVWCTSLH 91
Cdd:cd19105 13 VSRLGFGGGgLPRESP-----ELLRRALDLGINYFDTAEGYgngNSEEIIGEALK------GLRRDKVFLATKASPRLDK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 92 --PELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENfpvdehGKLIfdrvdlcatwEAMEKCKDAGLTKSIGVSNFN 169
Cdd:cd19105 82 kdKAELLKSVEESLKRLQTDYIDIYQLHGVDTPEERLLN------EELL----------EALEKLKKEGKVRFIGFSTHD 145
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126090770 170 YrQLEMILnkpglkykpvcNQVECHPY---------LNQ----MKLLDFCKSKDIVLVAYGVLGTQRYGGWVD 229
Cdd:cd19105 146 N-MAEVLQ-----------AAIESGWFdvimvaynfLNQpaelEEALAAAAEKGIGVVAMKTLAGGYLQPALL 206
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
41-299 |
2.23e-21 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 91.97 E-value: 2.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 41 AIDAGFHHFDSASVYNT---EDHVGEAIRSkiadgtvRREDIFYTSK---VW------CTSLHPELVRASLERSLQKLQF 108
Cdd:cd19102 35 ALDLGINWIDTAAVYGLghsEEVVGRALKG-------LRDRPIVATKcglLWdeegriRRSLKPASIRAECEASLRRLGV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 109 DYVDLYLIHYPMALKPGEEnfpvdehgklifdrvdlcaTWEAMEKCKDAGLTKSIGVSNFNYRQLEMIL-------NKPG 181
Cdd:cd19102 108 DVIDLYQIHWPDPDEPIEE-------------------AWGALAELKEEGKVRAIGVSNFSVDQMKRCQaihpiasLQPP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 182 lkYKPVCNQVEchpylnqMKLLDFCKSKDIVLVAYGVLG--------TQRY------GGWvDQNSPVlLDEP-------- 239
Cdd:cd19102 169 --YSLLRRGIE-------AEILPFCAEHGIGVIVYSPMQsglltgkmTPERvaslpaDDW-RRRSPF-FQEPnlarnlal 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126090770 240 --VLGSMAKKYNRTPALIALRYQLQRGIV--VLNTSLKEERIKENMQVFEFQLSSEDMKVLDGL 299
Cdd:cd19102 238 vdALRPIAERHGRTVAQLAIAWVLRRPEVtsAIVGARRPDQIDETVGAADLRLTPEELAEIEAL 301
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
17-285 |
2.85e-21 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 91.08 E-value: 2.85e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 17 PVLGFGTA-LPLECPKS----KAKELTKIAIDAGFHHFDSASVYNT---EDHVGEAIRskiadgTVRREDIFYTSKVWCT 88
Cdd:cd19096 1 SVLGFGTMrLPESDDDSideeKAIEMIRYAIDAGINYFDTAYGYGGgksEEILGEALK------EGPREKFYLATKLPPW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 89 SLH-PELVRASLERSLQKLQFDYVDLYLIH------YPMALKPGEenfpvdehgklifdrvdlcaTWEAMEKCKDAGLTK 161
Cdd:cd19096 75 SVKsAEDFRRILEESLKRLGVDYIDFYLLHglnspeWLEKARKGG--------------------LLEFLEKAKKEGLIR 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 162 SIGVSnF--NYRQLEMILNkpglkykpvCNQVEC----HPYLNQ-----MKLLDFCKSKDIVLVAYGVLGtqryGGWVDQ 230
Cdd:cd19096 135 HIGFS-FhdSPELLKEILD---------SYDFDFvqlqYNYLDQenqagRPGIEYAAKKGMGVIIMEPLK----GGGLAN 200
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 126090770 231 NSPVLLDEpvlgsmAKKYNRTPALIALRYQL-QRGI--VVLNTSLKEErIKENMQVFE 285
Cdd:cd19096 201 NPPEALAI------LCGAPLSPAEWALRFLLsHPEVttVLSGMSTPEQ-LDENIAAAD 251
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
16-297 |
3.42e-20 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 89.25 E-value: 3.42e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGT-AL-----PLECPKSKAKELTKIAIDAGFHHFDSASVYNT---EDHVGEAIRSkiadgtvRREDIFYTSK-- 84
Cdd:cd19149 11 ASVIGLGTwAIgggpwWGGSDDNESIRTIHAALDLGINLIDTAPAYGFghsEEIVGKAIKG-------RRDKVVLATKcg 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 85 -VWCTS----------------LHPELVRASLERSLQKLQFDYVDLYLIHYPmalkpgEENFPVDEhgklifdrvdlcaT 147
Cdd:cd19149 84 lRWDREggsfffvrdgvtvyknLSPESIREEVEQSLKRLGTDYIDLYQTHWQ------DVETPIEE-------------T 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 148 WEAMEKCKDAGLTKSIGVSNFNYRQLEMILNkpglkykpvCNQVEchpyLNQMK-----------LLDFCKSKDIVLVAY 216
Cdd:cd19149 145 MEALEELKRQGKIRAIGASNVSVEQIKEYVK---------AGQLD----IIQEKysmldrgiekeLLPYCKKNNIAFQAY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 217 GVL-----------------GTQRYG-GWVDQNS----PVLLDEpvLGSMAKKYNRTPALIALRYQLQRG--IVVLNTSL 272
Cdd:cd19149 212 SPLeqglltgkitpdrefdaGDARSGiPWFSPENrekvLALLEK--WKPLCEKYGCTLAQLVIAWTLAQPgiTSALCGAR 289
|
330 340
....*....|....*....|....*
gi 126090770 273 KEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19149 290 KPEQAEENAKAGDIRLSAEDIATMR 314
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
30-297 |
3.82e-20 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 88.80 E-value: 3.82e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 30 PKSKAKELTKIAIDAGFHHFDSASVYN---TEDHVGEAIRSKIadgtvRREDIFYTSKVW--------CTSLHPELVRAS 98
Cdd:cd19079 33 DEEESRPIIKRALDLGINFFDTANVYSggaSEEILGRALKEFA-----PRDEVVIATKVYfpmgdgpnGRGLSRKHIMAE 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 99 LERSLQKLQFDYVDLYLIHYPMALKPGEEnfpvdehgklifdrvdlcaTWEAMEKCKDAGLTKSIGVSNFNYRQLEMILN 178
Cdd:cd19079 108 VDASLKRLGTDYIDLYQIHRWDYETPIEE-------------------TLEALHDVVKSGKVRYIGASSMYAWQFAKALH 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 179 ---KPGLKyKPVCNQvechPYLNQM------KLLDFCKSKDIVLVAYGVLGTQRY-GGWVDQNS--------PVL----- 235
Cdd:cd19079 169 laeKNGWT-KFVSMQ----NHYNLLyreeerEMIPLCEEEGIGVIPWSPLARGRLaRPWGDTTErrrsttdtAKLkydyf 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 236 --LDEPVL---GSMAKKYNRTPALIALRYQLQRGIV---VLNTSlKEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19079 244 teADKEIVdrvEEVAKERGVSMAQVALAWLLSKPGVtapIVGAT-KLEHLEDAVAALDIKLSEEEIKYLE 312
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
11-294 |
4.71e-20 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 88.65 E-value: 4.71e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 11 NDGNFIPVLGFGT---ALPLECPKSKA---KELTKiAIDAGFHHFDSASVY-NTEDHVGEAIrsKIADGtvRREDIFYTS 83
Cdd:cd19144 8 RNGPSVPALGFGAmglSAFYGPPKPDEerfAVLDA-AFELGCTFWDTADIYgDSEELIGRWF--KQNPG--KREKIFLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 84 KV----------WCTSLHPELVRASLERSLQKLQFDYVDLYLIHypmalkpgeenfpvdehgklifdRVD----LCATWE 149
Cdd:cd19144 83 KFgieknvetgeYSVDGSPEYVKKACETSLKRLGVDYIDLYYQH-----------------------RVDgktpIEKTVA 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 150 AMEKCKDAGLTKSIGVSNFNYRQLemilnKPGLKYKPVCN-QVECHPYL-----NQMKLLDFCKSKDIVLVAYGVLG--- 220
Cdd:cd19144 140 AMAELVQEGKIKHIGLSECSAETL-----RRAHAVHPIAAvQIEYSPFSldierPEIGVLDTCRELGVAIVAYSPLGrgf 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 221 -TQRYGGWVD---------------QNSPV---LLDEpvLGSMAKKYNRTPALIALRYQLQRG--IVVLNTSLKEERIKE 279
Cdd:cd19144 215 lTGAIRSPDDfeegdfrrmaprfqaENFPKnleLVDK--IKAIAKKKNVTAGQLTLAWLLAQGddIIPIPGTTKLKRLEE 292
|
330
....*....|....*
gi 126090770 280 NMQVFEFQLSSEDMK 294
Cdd:cd19144 293 NLGALKVKLTEEEEK 307
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
19-282 |
7.25e-20 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 88.14 E-value: 7.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 19 LGFGTAL--PLECPKSKAKELTKIAIDAGFHHFDSASVY---NTEDHVGEAIRSKIADGTVRREDIFYTSKV-------- 85
Cdd:cd19099 6 LGLGTYRgdSDDETDEEYREALKAALDSGINVIDTAINYrggRSERLIGKALRELIEKGGIKRDEVVIVTKAgyipgdgd 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 86 -------W------------------CTSLHPELVRASLERSLQKLQFDYVDLYLIHYPmalkpgEENFPVDEHGKLiFD 140
Cdd:cd19099 86 eplrplkYleeklgrglidvadsaglRHCISPAYLEDQIERSLKRLGLDTIDLYLLHNP------EEQLLELGEEEF-YD 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 141 RVDlcATWEAMEKCKDAGLTKSIGVSNFN----------YRQLEMIL--------NKPGLKYkpVcnQVECHPYLNQ--- 199
Cdd:cd19099 159 RLE--EAFEALEEAVAEGKIRYYGISTWDgfrappalpgHLSLEKLVaaaeevggDNHHFKV--I--QLPLNLLEPEalt 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 200 ---------MKLLDFCKSKDIVLVAYGVLGTQRYGGwvdqnspvLLDEPVLGSMAKKynRTPALIALRYQL-QRGI-VVL 268
Cdd:cd19099 233 ekntvkgeaLSLLEAAKELGLGVIASRPLNQGQLLG--------ELRLADLLALPGG--ATLAQRALQFARsTPGVdSAL 302
|
330
....*....|....
gi 126090770 269 NTSLKEERIKENMQ 282
Cdd:cd19099 303 VGMRRPEHVDENLA 316
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
41-297 |
1.57e-19 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 86.98 E-value: 1.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 41 AIDAGFHHFDSASVYN---TEDHVGEAIRskiadGTVRREDIFYTSKV---W------CTSLHPELVRASLERSLQKLQF 108
Cdd:cd19148 34 ALDLGINLIDTAPVYGfglSEEIVGKALK-----EYGKRDRVVIATKVgleWdeggevVRNSSPARIRKEVEDSLRRLQT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 109 DYVDLYLIHYPMALKPGEEnfpvdehgklifdrvdlcaTWEAMEKCKDAGLTKSIGVSNFNYRQLEmilnkpglKYKPVC 188
Cdd:cd19148 109 DYIDLYQVHWPDPLVPIEE-------------------TAEALKELLDEGKIRAIGVSNFSPEQME--------TFRKVA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 189 NQVECHPYLN------QMKLLDFCKSKDIVLVAYGVL-----------GTQRYGGWVDQNSPvLLDEP----------VL 241
Cdd:cd19148 162 PLHTVQPPYNlfereiEKDVLPYARKHNIVTLAYGALcrgllsgkmtkDTKFEGDDLRRTDP-KFQEPrfsqylaaveEL 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 126090770 242 GSMAKK-YNRTPALIALRYQLQRGI--VVLNTSLKEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19148 241 DKLAQErYGKSVIHLAVRWLLDQPGvsIALWGARKPEQLDAVDEVFGWSLNDEDMKEID 299
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
42-297 |
2.64e-19 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 86.50 E-value: 2.64e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 42 IDAGFHHFDSASVYNT--EDHVG---EAIRSKIADGTVRREDIFYTSKVWC------TSLHPELVRASLERSLQKLQFDY 110
Cdd:cd19081 36 VDAGGNFIDTADVYSAwvPGNAGgesETIIGRWLKSRGKRDRVVIATKVGFpmgpngPGLSRKHIRRAVEASLRRLQTDY 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 111 VDLYLIHYPmalkpgEENFPVDEhgklifdrvdlcaTWEAMEKCKDAGLTKSIGVSNFNYRQLEMILN---KPGLKyKPV 187
Cdd:cd19081 116 IDLYQAHWD------DPATPLEE-------------TLGALNDLIRQGKVRYIGASNYSAWRLQEALElsrQHGLP-RYV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 188 CNQVEchpYlNQMK-------LLDFCKSKDIVLVAYGVLG----TQRY------------GGWVDQnspvLLDEP----- 239
Cdd:cd19081 176 SLQPE---Y-NLVDresfegeLLPLCREEGIGVIPYSPLAggflTGKYrseadlpgstrrGEAAKR----YLNERglril 247
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126090770 240 -VLGSMAKKYNRTPALIALRYQLQRGIV--VLNTSLKEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19081 248 dALDEVAAEHGATPAQVALAWLLARPGVtaPIAGARTVEQLEDLLAAAGLRLTDEEVARLD 308
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
41-299 |
6.64e-19 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 85.08 E-value: 6.64e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 41 AIDAGFHHFDSASVY---NTEDHVGEAIRskiadgTVRREDIFYTSKV--WCTSLHPELVRASLERSLQKLQFDYVDLYL 115
Cdd:cd19103 41 AMAAGLNLWDTAAVYgmgASEKILGEFLK------RYPREDYIISTKFtpQIAGQSADPVADMLEGSLARLGTDYIDIYW 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 116 IHYPMALkpgEENFPvdehgKLIfdrvdlcatweAMEKckdAGLTKSIGVSNFNYRQLEM---ILNKPGLKYKPVCNqve 192
Cdd:cd19103 115 IHNPADV---ERWTP-----ELI-----------PLLK---SGKVKHVGVSNHNLAEIKRaneILAKAGVSLSAVQN--- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 193 cHPYL-----NQMKLLDFCKSKDIVLVAYGVL-----------------GTQR---YGGWVDQnspvlLDE--PVLGSMA 245
Cdd:cd19103 170 -HYSLlyrssEEAGILDYCKENGITFFAYMVLeqgalsgkydtkhplpeGSGRaetYNPLLPQ-----LEEltAVMAEIG 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 126090770 246 KKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGL 299
Cdd:cd19103 244 AKHGASIAQVAIAWAIAKGTTPIIGVTKPHHVEDAARAASITLTDDEIKELEQL 297
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
17-166 |
4.29e-18 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 82.60 E-value: 4.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 17 PVLGFGTA----LPLECPKSKAKELTKIAIDAGFHHFDSASVY-NTEDHVGEAIRskiadgTVRREDIFYTSKV------ 85
Cdd:cd19090 1 SALGLGTAglggVFGGVDDDEAVATIRAALDLGINYIDTAPAYgDSEERLGLALA------ELPREPLVLSTKVgrlped 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 86 -WCTSlhPELVRASLERSLQKLQFDYVDLYLIHYPMALKpgeenfPVDEHGKlifdrvdlCATWEAMEKCKDAGLTKSIG 164
Cdd:cd19090 75 tADYS--ADRVRRSVEESLERLGRDRIDLLMIHDPERVP------WVDILAP--------GGALEALLELKEEGLIKHIG 138
|
..
gi 126090770 165 VS 166
Cdd:cd19090 139 LG 140
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
31-297 |
2.48e-17 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 81.07 E-value: 2.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 31 KSKAKELTKIAIDAGFHHFDSASVY----------NTEDHVGEAIRSKiadgtVRREDIFYTSKV--------WC----T 88
Cdd:cd19094 17 EAEAHEQLDYAFDEGVNFIDTAEMYpvppspetqgRTEEIIGSWLKKK-----GNRDKVVLATKVagpgegitWPrgggT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 89 SLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKP-GEENFPVDEHGKLIFdrVDLCATWEAMEKCKDAGLTKSIGVSN 167
Cdd:cd19094 92 RLDRENIREAVEGSLKRLGTDYIDLYQLHWPDRYTPlFGGGYYTEPSEEEDS--VSFEEQLEALGELVKAGKIRHIGLSN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 168 ------FNYRQLEMILNKPglkyKPVCNQvecHPY--LNQMKLLDF---CKSKDIVLVAY-----GVL------------ 219
Cdd:cd19094 170 etpwgvMKFLELAEQLGLP----RIVSIQ---NPYslLNRNFEEGLaeaCHRENVGLLAYsplagGVLtgkyldgaarpe 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 220 ---------GTQRYGGwvdQNSPVLLDEpvLGSMAKKYNRTPALIALRYQLQRGIVVLN----TSLkeERIKENMQVFEF 286
Cdd:cd19094 243 ggrlnlfpgYMARYRS---PQALEAVAE--YVKLARKHGLSPAQLALAWVRSRPFVTSTiigaTTL--EQLKENIDAFDV 315
|
330
....*....|.
gi 126090770 287 QLSSEDMKVLD 297
Cdd:cd19094 316 PLSDELLAEID 326
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
16-291 |
2.75e-17 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 80.71 E-value: 2.75e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTALPL--ECPKSKAKELTKIAIDAGFHHFDSASVYN---TEDHVGEAIRskiadgTVRREDIFYTSKV-WCTS 89
Cdd:cd19074 4 VSELSLGTWLTFggQVDDEDAKACVRKAYDLGINFFDTADVYAagqAEEVLGKALK------GWPRESYVISTKVfWPTG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 90 LHP-----------ELVRASLERslqkLQFDYVDLYLIHYPmalkpgEENFPVDEhgklifdrvdlcaTWEAMEKCKDAG 158
Cdd:cd19074 78 PGPndrglsrkhifESIHASLKR----LQLDYVDIYYCHRY------DPETPLEE-------------TVRAMDDLIRQG 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 159 LTKSIGVSNFNYRQLE--MILNKPGLKYKPVCNQVECHpYLNQMK---LLDFCKSKDIVLVAYGVL-------------- 219
Cdd:cd19074 135 KILYWGTSEWSAEQIAeaHDLARQFGLIPPVVEQPQYN-MLWREIeeeVIPLCEKNGIGLVVWSPLaqglltgkyrdgip 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 220 -------GTQRYGGWVDQnspvLLDEPV------LGSMAKKYNRTPALIALRYQLQRGIV---VLNTSlKEERIKENMQV 283
Cdd:cd19074 214 ppsrsraTDEDNRDKKRR----LLTDENlekvkkLKPIADELGLTLAQLALAWCLRNPAVssaIIGAS-RPEQLEENVKA 288
|
....*...
gi 126090770 284 FEFQLSSE 291
Cdd:cd19074 289 SGVKLSPE 296
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
41-168 |
3.07e-15 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 74.92 E-value: 3.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 41 AIDAGFHHFDSASVYN---TEDHVGEAIRSkiadgtvRREDIFYTSKV--------WCTSLHPELVRASLERSLQKLQFD 109
Cdd:cd19087 39 ALDAGINFFDTADVYGggrSEEIIGRWIAG-------RRDDIVLATKVfgpmgddpNDRGLSRRHIRRAVEASLRRLQTD 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 126090770 110 YVDLYLIHYPMALKPGEEnfpvdehgklifdrvdlcaTWEAMEKCKDAGLTKSIGVSNF 168
Cdd:cd19087 112 YIDLYQMHHFDRDTPLEE-------------------TLRALDDLVRQGKIRYIGVSNF 151
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
16-166 |
5.78e-15 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 72.90 E-value: 5.78e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGT---ALPLECPKS--KAKELTKIAIDAGFHHFDSASVY---NTEDHVGEAIRSkiadgtvRREDIFYTSKV-- 85
Cdd:cd19086 3 VSEIGFGTwglGGDWWGDVDdaEAIRALRAALDLGINFFDTADVYgdgHSERLLGKALKG-------RRDKVVIATKFgn 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 86 ---------WCTSlhPELVRASLERSLQKLQFDYVDLYLIHypmalKPGEENFPVDEHgklifdrvdlcatWEAMEKCKD 156
Cdd:cd19086 76 rfdggperpQDFS--PEYIREAVEASLKRLGTDYIDLYQLH-----NPPDEVLDNDEL-------------FEALEKLKQ 135
|
170
....*....|
gi 126090770 157 AGLTKSIGVS 166
Cdd:cd19086 136 EGKIRAYGVS 145
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
41-261 |
9.64e-15 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 73.45 E-value: 9.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 41 AIDAGFHHFDSASVYN---TEDHVGEAIRSKiadgtvrREDIFYTSKVwctSLHPEL-------VRASLERSLQKLQFDY 110
Cdd:cd19104 41 ALDLGINFFDTAPSYGdgkSEENLGRALKGL-------PAGPYITTKV---RLDPDDlgdiggqIERSVEKSLKRLKRDS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 111 VDLYLIH---YPMALKPGEENFPVDehgklifDRVDLCATWEAMEKCKDAGLTKSIGVSNF-NYRQLEMIL--NKPG--- 181
Cdd:cd19104 111 VDLLQLHnriGDERDKPVGGTLSTT-------DVLGLGGVADAFERLRSEGKIRFIGITGLgNPPAIRELLdsGKFDavq 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 182 -----LKYKPVCNQVECHPYLNQMKLLDFCKSKD-----IVLVAYGVLGTQRYGGWVDQNSPVLLDEPVLGSMAK----- 246
Cdd:cd19104 184 vyynlLNPSAAEARPRGWSAQDYGGIIDAAAEHGvgvmgIRVLAAGALTTSLDRGREAPPTSDSDVAIDFRRAAAfrala 263
|
250
....*....|....*.
gi 126090770 247 -KYNRTPALIALRYQL 261
Cdd:cd19104 264 rEWGETLAQLAHRFAL 279
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
30-285 |
1.17e-14 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 72.56 E-value: 1.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 30 PKSKAKELTKIAIDAGFHHFDSASVY-NTEDHVGEAIrskiadgtVRREDIFYTSKV----WCTSLHPELVRASLERSLQ 104
Cdd:cd19097 24 SEKEAKKILEYALKAGINTLDTAPAYgDSEKVLGKFL--------KRLDKFKIITKLpplkEDKKEDEAAIEASVEASLK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 105 KLQFDYVDLYLIHYPMALkpgeenfpvDEHGKLIfdrvdlcatWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKPGLKY 184
Cdd:cd19097 96 RLKVDSLDGLLLHNPDDL---------LKHGGKL---------VEALLELKKEGLIRKIGVSVYSPEELEKALESFKIDI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 185 kpVcnQVECHPY---LNQMKLLDFCKSKDIVLVA-----YGVLGT--QRYGGWVDQNSPVLLDepvLGSMAKKYNRTPAL 254
Cdd:cd19097 158 --I--QLPFNILdqrFLKSGLLAKLKKKGIEIHArsvflQGLLLMepDKLPAKFAPAKPLLKK---LHELAKKLGLSPLE 230
|
250 260 270
....*....|....*....|....*....|....*
gi 126090770 255 IALRYQLQR----GIVVLNTSLKEerIKENMQVFE 285
Cdd:cd19097 231 LALGFVLSLpeidKIVVGVDSLEQ--LKEIIAAFK 263
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
41-294 |
5.02e-13 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 68.40 E-value: 5.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 41 AIDAGFHHFDSASVYNT---EDHVGEAIRSkiadgtvRREDIFYTSK---VWC-------TSLHPELVRASLERSLQKLQ 107
Cdd:cd19076 41 ALELGVTFLDTADMYGPgtnEELLGKALKD-------RRDEVVIATKfgiVRDpgsgfrgVDGRPEYVRAACEASLKRLG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 108 FDYVDLYLIHYPmalkpgEENFPVDEhgklifdrvdlcaTWEAMEKCKDAGLTKSIGVSNFNYRQ------------LEM 175
Cdd:cd19076 114 TDVIDLYYQHRV------DPNVPIEE-------------TVGAMAELVEEGKVRYIGLSEASADTirrahavhpitaVQS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 176 ilnkpglKYKPVCNQVECHpylnqmkLLDFCKSKDIVLVAYGVLG----------------------TQRYGGWVDQNSP 233
Cdd:cd19076 175 -------EYSLWTRDIEDE-------VLPTCRELGIGFVAYSPLGrgfltgaikspedlpeddfrrnNPRFQGENFDKNL 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126090770 234 VLLDEpvLGSMAKKYNRTPALIALRYQLQRG--IVVLNTSLKEERIKENMQVFEFQLSSEDMK 294
Cdd:cd19076 241 KLVEK--LEAIAAEKGCTPAQLALAWVLAQGddIVPIPGTKRIKYLEENVGALDVVLTPEELA 301
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
31-297 |
1.04e-12 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 67.26 E-value: 1.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 31 KSKAKELTKIAIDAGFHHFDSASVYNT---EDHVGEAIRSkiadgtvRREDIFYTSKVWCTSLH-----------PELVR 96
Cdd:cd19078 24 KEEMIELIRKAVELGITFFDTAEVYGPytnEELVGEALKP-------FRDQVVIATKFGFKIDGgkpgplgldsrPEHIR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 97 ASLERSLQKLQFDYVDLYLIHYPmalkpgEENFPVDEhgklifdrvdlcaTWEAMEKCKDAGLTKSIGVSNFNYRQLEmi 176
Cdd:cd19078 97 KAVEGSLKRLQTDYIDLYYQHRV------DPNVPIEE-------------VAGTMKELIKEGKIRHWGLSEAGVETIR-- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 177 lnkpglKYKPVC---------NQVECHPylnQMKLLDFCKSKDIVLVAYGVLG----TQRYG-----------GWVDQNS 232
Cdd:cd19078 156 ------RAHAVCpvtavqseySMMWREP---EKEVLPTLEELGIGFVPFSPLGkgflTGKIDentkfdegddrASLPRFT 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126090770 233 P-------VLLDepVLGSMAKKYNRTPALIALRYQLQRG--IVVLNTSLKEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19078 227 PealeanqALVD--LLKEFAEEKGATPAQIALAWLLAKKpwIVPIPGTTKLSRLEENIGAADIELTPEELREIE 298
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
17-167 |
2.13e-12 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 66.42 E-value: 2.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 17 PVLGFGTA-LPLECPKSKAKELTKIAIDAGFHHFDSASVYN-------TEDHVGEAIRSKIadgtvRREDIFYTSK---- 84
Cdd:cd19082 1 SRIVLGTAdFGTRIDEEEAFALLDAFVELGGNFIDTARVYGdwvergaSERVIGEWLKSRG-----NRDKVVIATKgghp 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 85 ----VWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYpmalkpGEENFPVDEhgkLIfdrvdlcatwEAMEKCKDAGLT 160
Cdd:cd19082 76 dledMSRSRLSPEDIRADLEESLERLGTDYIDLYFLHR------DDPSVPVGE---IV----------DTLNELVRAGKI 136
|
....*..
gi 126090770 161 KSIGVSN 167
Cdd:cd19082 137 RAFGASN 143
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
8-216 |
1.14e-11 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 64.50 E-value: 1.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 8 VILNDGNFIPVLGFGTAlplecpkSKAKELTKIAIDAGFHHFDSASVYN---TEDHVGEAIRS----KIAdgtvrredif 80
Cdd:cd19075 3 IILGTMTFGSQGRFTTA-------EAAAELLDAFLERGHTEIDTARVYPdgtSEELLGELGLGergfKID---------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 81 ytSKV---WCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPmalkpgEENFPVDEhgklifdrvdlcaTWEAMEKCKDA 157
Cdd:cd19075 66 --TKAnpgVGGGLSPENVRKQLETSLKRLKVDKVDVFYLHAP------DRSTPLEE-------------TLAAIDELYKE 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126090770 158 GLTKSIGVSNFNYRQLEMILN--------KP----GLkYKPVCNQVEchpylnqMKLLDFCKSKDIVLVAY 216
Cdd:cd19075 125 GKFKEFGLSNYSAWEVAEIVEickengwvLPtvyqGM-YNAITRQVE-------TELFPCLRKLGIRFYAY 187
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
21-192 |
1.75e-11 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 64.15 E-value: 1.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 21 FGTALPLEcpksKAKELTKIAIDAGFHHFDSASVY---NTEDHVGEAIRskiaDGTVRREDIFYTSKV-WCTSLHP---- 92
Cdd:cd19143 24 FGNQVDVD----EAKECMKAAYDAGVNFFDNAEVYangQSEEIMGQAIK----ELGWPRSDYVVSTKIfWGGGGPPpndr 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 93 --------ELVRASLERslqkLQFDYVDLYLIHYPMALKPGEEnfpvdehgklifdrvdlcaTWEAMEKCKDAGLTKSIG 164
Cdd:cd19143 96 glsrkhivEGTKASLKR----LQLDYVDLVFCHRPDPATPIEE-------------------TVRAMNDLIDQGKAFYWG 152
|
170 180 190
....*....|....*....|....*....|.
gi 126090770 165 VSNFNYRQLE---MILNKPGLkYKPVCNQVE 192
Cdd:cd19143 153 TSEWSAQQIEeahEIADRLGL-IPPVMEQPQ 182
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
21-297 |
2.79e-11 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 63.39 E-value: 2.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 21 FGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYN---TEDHVGEAIRSkiadgtvRREDIFYTSKvWCTSLHP----- 92
Cdd:cd19080 20 FGTEWGWGADREEARAMFDAYVEAGGNFIDTANNYTngtSERLLGEFIAG-------NRDRIVLATK-YTMNRRPgdpna 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 93 -----ELVRASLERSLQKLQFDYVDLYLIHYPmalkpgEENFPVDE--HGkliFDrvDLCAtweamekckdAGLTKSIGV 165
Cdd:cd19080 92 ggnhrKNLRRSVEASLRRLQTDYIDLLYVHAW------DFTTPVEEvmRA---LD--DLVR----------AGKVLYVGI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 166 SNF------------NYRQLEMILnkpGL--KYKPVCNQVEchpylnqMKLLDFCKSKDIVLVAYGVLG----------- 220
Cdd:cd19080 151 SDTpawvvarantlaELRGWSPFV---ALqiEYSLLERTPE-------RELLPMARALGLGVTPWSPLGgglltgkyqrg 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 221 --TQRYGGWVDQNSPVLLDE------PVLGSMAKKYNRTPALIALRYQLQR---GIVVLNTSlKEERIKENMQVFEFQLS 289
Cdd:cd19080 221 eeGRAGEAKGVTVGFGKLTErnwaivDVVAAVAEELGRSAAQVALAWVRQKpgvVIPIIGAR-TLEQLKDNLGALDLTLS 299
|
....*...
gi 126090770 290 SEDMKVLD 297
Cdd:cd19080 300 PEQLARLD 307
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
16-220 |
7.52e-11 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 61.80 E-value: 7.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTAlPL-----ECPKSKAKELTKIAIDAGFHHFDSASVYN---TEDHVGEAIRskiadgTVRREDIFYTSKVWC 87
Cdd:cd19163 13 VSKLGFGAS-PLggvfgPVDEEEAIRTVHEALDSGINYIDTAPWYGqgrSETVLGKALK------GIPRDSYYLATKVGR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 88 TSLHP--------ELVRASLERSLQKLQFDYVDLYLIHYPmalkpgeenfpvdEHGKLIfDRVdLCATWEAMEKCKDAGL 159
Cdd:cd19163 86 YGLDPdkmfdfsaERITKSVEESLKRLGLDYIDIIQVHDI-------------EFAPSL-DQI-LNETLPALQKLKEEGK 150
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 160 TKSIGVSNFNYRQLEMILNKPG------LKYkpvcnqveCHPYLNQ---MKLLDFCKSKDIVLVAYGVLG 220
Cdd:cd19163 151 VRFIGITGYPLDVLKEVLERSPvkidtvLSY--------CHYTLNDtslLELLPFFKEKGVGVINASPLS 212
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
17-219 |
8.43e-11 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 61.61 E-value: 8.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 17 PVLGFGTA---LPLECPKSKAKELTKIAIDAGFHHFDSASVYN---TEDHVGEAIRSKiadgtvRREDIFYTSKV----- 85
Cdd:cd19162 1 PRLGLGAAslgNLARAGEDEAAATLDAAWDAGIRYFDTAPLYGlglSERRLGAALARH------PRAEYVVSTKVgrlle 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 86 -------------WCTSlhPELVRASLERSLQKLQFDYVDLYLIHYPmalkpgeenfpvDEHgklifDRVDLCATWEAME 152
Cdd:cd19162 75 pgaagrpagadrrFDFS--ADGIRRSIEASLERLGLDRLDLVFLHDP------------DRH-----LLQALTDAFPALE 135
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 153 KCKDAGLTKSIGVSNFNYRQLEMILNKPGLKYKPVCNQvecHPYLNQ---MKLLDFCKSKDIVLVAYGVL 219
Cdd:cd19162 136 ELRAEGVVGAIGVGVTDWAALLRAARRADVDVVMVAGR---YTLLDRraaTELLPLCAAKGVAVVAAGVF 202
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
16-308 |
1.75e-10 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 61.02 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGT-ALPLECPKSKAKELTKIAIDAGFHHFDSASVYN----------TEDHVGEAIRSKiadgtVRREDIFYTSK 84
Cdd:PRK10625 13 VSTLGLGTmTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPvpprpetqglTETYIGNWLAKR-----GSREKLIIASK 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 85 VWC------TSLHPEL------VRASLERSLQKLQFDYVDLYLIHYPMAlkpgeenfPVDEHGKLIFDRVD------LCA 146
Cdd:PRK10625 88 VSGpsrnndKGIRPNQaldrknIREALHDSLKRLQTDYLDLYQVHWPQR--------PTNCFGKLGYSWTDsapavsLLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 147 TWEAMEKCKDAGLTKSIGVSN------FNYRQLEMILNKPglkyKPVCNQvecHPY--LN---QMKLLDFCKSKDIVLVA 215
Cdd:PRK10625 160 TLDALAEQQRAGKIRYIGVSNetafgvMRYLHLAEKHDLP----RIVTIQ---NPYslLNrsfEVGLAEVSQYEGVELLA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 216 YGVL--GT----------------------QRYGGWVDQNSpvlLDEPVlgSMAKKYNRTPALIALRYQLQRGIVVLN-- 269
Cdd:PRK10625 233 YSCLafGTltgkylngakpagarntlfsrfTRYSGEQTQKA---VAAYV--DIAKRHGLDPAQMALAFVRRQPFVASTll 307
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 126090770 270 --TSLkeERIKENMQVFEFQLSSEDMKVLDGLNRNMRYiPA 308
Cdd:PRK10625 308 gaTTM--EQLKTNIESLHLTLSEEVLAEIEAVHQVYTY-PA 345
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
14-297 |
2.69e-10 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 60.33 E-value: 2.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 14 NFIPV--LGFG----TALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDH------VGEAIRSKIADgtvrREDIFY 81
Cdd:cd19077 1 NGKLVgpIGLGlmglTWRPNPTPDEEAFETMKAALDAGSNLWNGGEFYGPPDPhanlklLARFFRKYPEY----ADKVVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 82 TSKV-WCTSLH-----PELVRASLERSLQKLQF-DYVDLYlihYPMALKPgeeNFPVDEhgklifdrvdlcaTWEAMEKC 154
Cdd:cd19077 77 SVKGgLDPDTLrpdgsPEAVRKSIENILRALGGtKKIDIF---EPARVDP---NVPIEE-------------TIKALKEL 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 155 KDAGLTKSIGVSNFNYRQLEMILnkpglKYKPV-CNQVECHPYLN---QMKLLDFCKSKDIVLVAYGVLG----TQRY-- 224
Cdd:cd19077 138 VKEGKIRGIGLSEVSAETIRRAH-----AVHPIaAVEVEYSLFSReieENGVLETCAELGIPIIAYSPLGrgllTGRIks 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 225 -----GGWVDQNSP-----------VLLDEpvLGSMAKKYNRTPALIAL---RYQLQRGIVVLNTSLKEERIKENMQVFE 285
Cdd:cd19077 213 ladipEGDFRRHLDrfngenfeknlKLVDA--LQELAEKKGCTPAQLALawiLAQSGPKIIPIPGSTTLERVEENLKAAN 290
|
330
....*....|..
gi 126090770 286 FQLSSEDMKVLD 297
Cdd:cd19077 291 VELTDEELKEIN 302
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
20-280 |
3.20e-10 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 59.96 E-value: 3.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 20 GFGTALPLEcpksKAKELTKIAIDAGFHHFDSASVY-----NTEDHVGEAIRSkiaDGTVRREDIFYTSKV--------- 85
Cdd:cd19089 21 NFGDYTSPE----EARELLRTAFDLGITHFDLANNYgpppgSAEENFGRILKR---DLRPYRDELVISTKAgygmwpgpy 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 86 --WCTSLHpelVRASLERSLQKLQFDYVDLYLIHYPmalkpgEENFPVDEhgklifdrvdlcaTWEAMEKCKDAGLTKSI 163
Cdd:cd19089 94 gdGGSRKY---LLASLDQSLKRMGLDYVDIFYHHRY------DPDTPLEE-------------TMTALADAVRSGKALYV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 164 GVSNFNYRQLEM---ILNKpgLKYKPVCNQVechPY--LNQ---MKLLDFCKSKDIVLVAY-----GVLGTQRYGGWVDQ 230
Cdd:cd19089 152 GISNYPGAKARRaiaLLRE--LGVPLIIHQP---RYslLDRwaeDGLLEVLEEAGIGFIAFsplaqGLLTDKYLNGIPPD 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 126090770 231 NS---------PVLLDEPV------LGSMAKKYNRTPALIALRYQLQRGIV--VLNTSLKEERIKEN 280
Cdd:cd19089 227 SRraaeskfltEEALTPEKleqlrkLNKIAAKRGQSLAQLALSWVLRDPRVtsVLIGASSPSQLEDN 293
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
21-297 |
6.38e-09 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 56.54 E-value: 6.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 21 FGTALPLECPKSkakeLTKIAIDAGFHHFDSASVY-----NTEDHVGEAIRSKIAdgtVRREDIFYTSK----VW----C 87
Cdd:PRK09912 36 FGHVNALESQRA----ILRKAFDLGITHFDLANNYgpppgSAEENFGRLLREDFA---AYRDELIISTKagydMWpgpyG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 88 TSLHPELVRASLERSLQKLQFDYVDLYLIHYPmalkpgEENFPVDEhgklifdrvdlcaTWEAMEKCKDAGLTKSIGVSN 167
Cdd:PRK09912 109 SGGSRKYLLASLDQSLKRMGLEYVDIFYSHRV------DENTPMEE-------------TASALAHAVQSGKALYVGISS 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 168 FN-YRQLEM--ILNK---PGLKYKPVCNQVecHPYLNQMKLLDFCKSKDIVLVAYGVLG-----------------TQRY 224
Cdd:PRK09912 170 YSpERTQKMveLLREwkiPLLIHQPSYNLL--NRWVDKSGLLDTLQNNGVGCIAFTPLAqglltgkylngipqdsrMHRE 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 225 GGWVDQNSPVLLDEPVLGS------MAKKYNRTPALIALRYQL--QRGIVVLNTSLKEERIKENMQVFE-FQLSSEDMKV 295
Cdd:PRK09912 248 GNKVRGLTPKMLTEANLNSlrllneMAQQRGQSMAQMALSWLLkdERVTSVLIGASRAEQLEENVQALNnLTFSTEELAQ 327
|
..
gi 126090770 296 LD 297
Cdd:PRK09912 328 ID 329
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
42-282 |
1.01e-08 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 55.42 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 42 IDAGFHHFDSASVYNT----------EDHVGEAIRSKIAdgtvrREDIFYTSKV---------WCTS---LHPELVRASL 99
Cdd:cd19752 27 VAAGGNFLDTANNYAFwteggvggesERLIGRWLKDRGN-----RDDVVIATKVgagprdpdgGPESpegLSAETIEQEI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 100 ERSLQKLQFDYVDLYLIHypmalkpgeenfpvdehgklIFDR-VDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEM--- 175
Cdd:cd19752 102 DKSLRRLGTDYIDLYYAH--------------------VDDRdTPLEETLEAFNELVKAGKVRAIGASNFAAWRLERarq 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 176 ILNKPGLKyKPVCNQVEcHPYL---------NQM----KLLDFCKS-KDIVLVAYgvlGTQRYGGWVDQNSPVL--LDEP 239
Cdd:cd19752 162 IARQQGWA-EFSAIQQR-HSYLrprpgadfgVQRivtdELLDYASSrPDLTLLAY---SPLLSGAYTRPDRPLPeqYDGP 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 126090770 240 -------VLGSMAKKYNRTPALIALRYQLQR--GIVVLNTSLKEERIKENMQ 282
Cdd:cd19752 237 dsdarlaVLEEVAGELGATPNQVVLAWLLHRtpAIIPLLGASTVEQLEENLA 288
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
30-296 |
2.27e-08 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 54.36 E-value: 2.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 30 PKSKAKELTKIAIDAGFHHFDSASVY--NT-EDHVGEAIRSKIadgtvrREDIFYTSKVWCTSLH---------PELVRA 97
Cdd:cd19145 31 PEEEGIALIHHAFNSGVTFLDTSDIYgpNTnEVLLGKALKDGP------REKVQLATKFGIHEIGgsgvevrgdPAYVRA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 98 SLERSLQKLQFDYVDLYLIHYpmalkpgeenfpVDEhgklifdRVDLCATWEAMEKCKDAGLTKSIGVSNFN---YRQLE 174
Cdd:cd19145 105 ACEASLKRLDVDYIDLYYQHR------------IDT-------TVPIEITMGELKKLVEEGKIKYIGLSEASadtIRRAH 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 175 MIlnkpglkyKPVCN-QVECHPYLNQMK--LLDFCKSKDIVLVAYGVLGT----------------------QRY-GGWV 228
Cdd:cd19145 166 AV--------HPITAvQLEWSLWTRDIEeeIIPTCRELGIGIVPYSPLGRgffagkakleellensdvrkshPRFqGENL 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 229 DQNSpVLLDEpvLGSMAKKYNRTPALIALRYQLQRG--IVVLNTSLKEERIKENMQVFEFQLSSEDMKVL 296
Cdd:cd19145 238 EKNK-VLYER--VEALAKKKGCTPAQLALAWVLHQGedVVPIPGTTKIKNLNQNIGALSVKLTKEDLKEI 304
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
16-209 |
8.43e-07 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 49.77 E-value: 8.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGT--ALPLECPKSKAKELTKIAIDAGFHHFDSASVY---NTEDHVGEAIRSKiadGTVRREDIFYTSKVWCTS- 89
Cdd:cd19142 13 VSNVGLGTwsTFSTAISEEQAEEIVTLAYENGINYFDTSDAFtsgQAETELGRILKKK---GWKRSSYIVSTKIYWSYGs 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 90 ----LHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEE-----NFPVDeHGKLIFDRvdlCATWEAMEkckdaglt 160
Cdd:cd19142 90 eergLSRKHIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEvvramSYLID-NGLIMYWG---TSRWSPVE-------- 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 126090770 161 ksIGVSNFNYRQLEMILnkpglkykPVCNQVECHPylnqmklldFCKSK 209
Cdd:cd19142 158 --IMEAFSIARQFNCPT--------PICEQSEYHM---------FCREK 187
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
16-194 |
9.20e-07 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 49.66 E-value: 9.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTALPL--ECPKSKAKELTKIAIDAGFHHFDSASVY---NTEDHVGEAIRSKiadgTVRREDIFYTSKV-WCTS 89
Cdd:cd19159 13 VSCLGLGTWVTFggQISDEVAERLMTIAYESGVNLFDTAEVYaagKAEVILGSIIKKK----GWRRSSLVITTKLyWGGK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 90 LHPE--LVRA----SLERSLQKLQFDYVDLYLIHYPMALKPGEE-----NFPVDEHGKLIFDrvdlCATWEAMEkckdag 158
Cdd:cd19159 89 AETErgLSRKhiieGLKGSLQRLQLEYVDVVFANRPDSNTPMEEivramTHVINQGMAMYWG----TSRWSAME------ 158
|
170 180 190
....*....|....*....|....*....|....*.
gi 126090770 159 LTKSIGVSnfnyRQLEMIlnkpglkyKPVCNQVECH 194
Cdd:cd19159 159 IMEAYSVA----RQFNMI--------PPVCEQAEYH 182
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
19-168 |
1.10e-06 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 49.46 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 19 LGFGTAL-------PLEcpKSKAKELTKIAIDAGFHHFDSASVYN---TEDHVGEAIRSKiadgTVRREDIFYTSKV--W 86
Cdd:cd19153 15 VGLGTAAlggvygdGLE--QDEAVAIVAEAFAAGINHFDTSPYYGaesSEAVLGKALAAL----QVPRSSYTVATKVgrY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 87 CTSLH---PELVRASLERSLQKLQFDYVDLYLIHypmalkpgeenfpvD-EHGKLIfdrVDLCATWEAMEKCKDAGLTKS 162
Cdd:cd19153 89 RDSEFdysAERVRASVATSLERLHTTYLDVVYLH--------------DiEFVDYD---TLVDEALPALRTLKDEGVIKR 151
|
....*.
gi 126090770 163 IGVSNF 168
Cdd:cd19153 152 IGIAGY 157
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
16-117 |
1.22e-06 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 49.20 E-value: 1.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTA--------LPLECPkskAKELTKIAIDAGFHHFDSASVY-NTEDHVGEAIrSKIADGtVRREDIFYTSKV- 85
Cdd:cd19164 13 LPPLIFGAAtfsyqyttDPESIP---PVDIVRRALELGIRAFDTSPYYgPSEIILGRAL-KALRDE-FPRDTYFIITKVg 87
|
90 100 110
....*....|....*....|....*....|....*.
gi 126090770 86 ----WCTSLHPELVRASLERSLQKLQFDYVDLYLIH 117
Cdd:cd19164 88 rygpDDFDYSPEWIRASVERSLRRLHTDYLDLVYLH 123
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
28-297 |
2.07e-06 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 48.57 E-value: 2.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 28 ECPKSKAKELTKIAIDAGFHHFDSASVYNTEDH---VGE-----------AIRSKIADGTVRREDIfyTSKVWCTSLHPE 93
Cdd:cd19146 31 ECDKETAFKLLDAFYEQGGNFIDTANNYQGEESerwVGEwmasrgnrdemVLATKYTTGYRRGGPI--KIKSNYQGNHAK 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 94 LVRASLERSLQKLQFDYVDLYLIHYPMALKPGEE-----NFPVDEhGKLIFDRVDLCATW---EAMEKCKDAGLTKSI-- 163
Cdd:cd19146 109 SLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPElmqslNHLVAA-GKVLYLGVSDTPAWvvsKANAYARAHGLTQFVvy 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 164 -GVSNFNYRQLEmilnkpglkykpvcnqvechpylnqMKLLDFCKSKDIVLVAYGVLG---------------TQRYGGw 227
Cdd:cd19146 188 qGHWSAAFRDFE-------------------------RDILPMCEAEGMALAPWGVLGqgqfrteeefkrrgrSGRKGG- 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 126090770 228 vDQNSPVLLDEPVLGSMAKKYNRTPALIALRYQLQRGIVVLNT--SLKEERIKENMQVFEFQLSSEDMKVLD 297
Cdd:cd19146 242 -PQTEKERKVSEKLEKVAEEKGTAITSVALAYVMHKAPYVFPIvgGRKVEHLKGNIEALGISLSDEEIQEIE 312
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
16-127 |
7.70e-06 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 46.67 E-value: 7.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTALPL--ECPKSKAKELTKIAIDAGFHHFDSASVY---NTEDHVGEAIRSKiadgTVRREDIFYTSKV-WCTS 89
Cdd:cd19141 12 VSCLGLGTWVTFgsQISDEVAEELVTLAYENGINLFDTAEVYaagKAEIVLGKILKKK----GWRRSSYVITTKIfWGGK 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 126090770 90 LHPE--LVRA----SLERSLQKLQFDYVDLYLIHYPMALKPGEE 127
Cdd:cd19141 88 AETErgLSRKhiieGLKASLERLQLEYVDIVFANRPDPNTPMEE 131
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
21-285 |
9.23e-06 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 46.68 E-value: 9.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 21 FGTALPLEcpksKAKELTKIAIDAGFHHFDSASVY-----NTEDHVGEAIRSKIADgtvRREDIFYTSKV---------- 85
Cdd:cd19150 23 FGDDTPLE----TQRAILRTAFDLGITHFDLANNYgpppgSAEENFGRILREDFAG---YRDELIISTKAgydmwpgpyg 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 86 -WCTSlhpELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEEnfpvdehgklifdrvdlcaTWEAMEKCKDAGLTKSIG 164
Cdd:cd19150 96 eWGSR---KYLLASLDQSLKRMGLDYVDIFYSHRFDPDTPLEE-------------------TMGALDHAVRSGKALYVG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 165 VSNFN---YRQLEMILNK---PGLKYKPVCNQVecHPYLNQMKLLDFCKSKDIVLVAYGVLG----TQRYGGWVDQNS-- 232
Cdd:cd19150 154 ISSYSperTREAAAILRElgtPLLIHQPSYNML--NRWVEESGLLDTLQELGVGCIAFTPLAqgllTDKYLNGIPEGSra 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126090770 233 -------PVLLDEPVLGS------MAKKYNRTPALIALRYQLQRGIV--VLNTSLKEERIKENMQVFE 285
Cdd:cd19150 232 skerslsPKMLTEANLNSiralneIAQKRGQSLAQMALAWVLRDGRVtsALIGASRPEQLEENVGALD 299
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
16-297 |
9.79e-06 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 46.69 E-value: 9.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTAlPL-----ECPKSKAKELTKIAIDAGFHHFDSASVYN---TEDHVGEAIRSKiadgTVRREDIFYTSKvwC 87
Cdd:PLN02587 11 VSSVGFGAS-PLgsvfgPVSEEDAIASVREAFRLGINFFDTSPYYGgtlSEKVLGKALKAL----GIPREKYVVSTK--C 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 88 T------SLHPELVRASLERSLQKLQFDYVDLYLIHypmalkpgeenfpvD-EHGKLifDRVdLCATWEAMEKCKDAGLT 160
Cdd:PLN02587 84 GrygegfDFSAERVTKSVDESLARLQLDYVDILHCH--------------DiEFGSL--DQI-VNETIPALQKLKESGKV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 161 KSIGVSNFNYRQLEMILNK--PG-----LKYkpvcnqveCHPYLNQMKLLD---FCKSKDIVLV-----AYGVLGTQRYG 225
Cdd:PLN02587 147 RFIGITGLPLAIFTYVLDRvpPGtvdviLSY--------CHYSLNDSSLEDllpYLKSKGVGVIsasplAMGLLTENGPP 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 226 GWvdQNSPVLLDEPVLGSMA--KKYNRTPALIALRYQLQRG-----IVVLNTSlkeERIKENMQ-VFEFQLSSEDMKVLD 297
Cdd:PLN02587 219 EW--HPAPPELKSACAAAAThcKEKGKNISKLALQYSLSNKdisttLVGMNSV---QQVEENVAaATELETSGIDEELLS 293
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
16-194 |
3.86e-05 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 44.59 E-value: 3.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTALPL--ECPKSKAKELTKIAIDAGFHHFDSASVY---NTEDHVGEAIRSKiadgTVRREDIFYTSKV-WCTS 89
Cdd:cd19160 15 VSCLGLGTWVTFgsQISDETAEDLLTVAYEHGVNLFDTAEVYaagKAERTLGNILKSK----GWRRSSYVVTTKIyWGGQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 90 LHPE--LVRA----SLERSLQKLQFDYVDLYLIHYPMALKPGEE-----NFPVDEHGKLIFDrvdlCATWEAMEkckdag 158
Cdd:cd19160 91 AETErgLSRKhiieGLRGSLDRLQLEYVDIVFANRSDPNSPMEEivramTYVINQGMAMYWG----TSRWSAME------ 160
|
170 180 190
....*....|....*....|....*....|....*.
gi 126090770 159 LTKSIGVSnfnyRQLEMIlnkpglkyKPVCNQVECH 194
Cdd:cd19160 161 IMEAYSVA----RQFNLI--------PPVCEQAEYH 184
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
16-196 |
8.96e-05 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 43.54 E-value: 8.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 16 IPVLGFGTALPL--ECPKSKAKELTKIAIDAGFHHFDSASVY---NTEDHVGEAIRSKiadgTVRREDIFYTSKV-WCTS 89
Cdd:cd19158 13 VSCLGLGTWVTFggQITDEMAEHLMTLAYDNGINLFDTAEVYaagKAEVVLGNIIKKK----GWRRSSLVITTKIfWGGK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 90 LHPE--LVRA----SLERSLQKLQFDYVDLYLIHYPMALKPGEENFPVDEHgkLIFDRVDL---CATWEAMEkckdagLT 160
Cdd:cd19158 89 AETErgLSRKhiieGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTH--VINQGMAMywgTSRWSSME------IM 160
|
170 180 190
....*....|....*....|....*....|....*.
gi 126090770 161 KSIGVSnfnyRQLEMIlnkpglkyKPVCNQVECHPY 196
Cdd:cd19158 161 EAYSVA----RQFNLI--------PPICEQAEYHMF 184
|
|
| PRK14863 |
PRK14863 |
bifunctional regulator KidO; Provisional |
20-166 |
1.34e-04 |
|
bifunctional regulator KidO; Provisional
Pssm-ID: 184865 [Multi-domain] Cd Length: 292 Bit Score: 42.98 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 20 GFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHV-GEAIRS----KIADGTVRredifytskvwcTSLHPEL 94
Cdd:PRK14863 20 GSSSAPRGRTPEAEARDILNIAARAGLSVLDASGLFGRAETVlGQLIPRpvpfRVTLSTVR------------ADRGPDF 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 126090770 95 VRASLERSLQKLQFDYVDLYLIHYPMALkpgeenfpVDEHGKlifdrvdlcATWEAMEKCKDAGLTKSIGVS 166
Cdd:PRK14863 88 VEAEARASLRRMGVERADAILVHSPTEL--------FGPHGA---------ALWERLQALKDQGLFAKIGVS 142
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
34-127 |
2.06e-04 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 42.39 E-value: 2.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090770 34 AKELTKIAIDAGFHHFDSASVY-----NTEDHVGEAIRSKIADgtvRREDIFYTSKV-----------WCTSLHpeLVrA 97
Cdd:cd19151 32 SRAMLRRAFDLGITHFDLANNYgpppgSAEENFGRILKEDLKP---YRDELIISTKAgytmwpgpygdWGSKKY--LI-A 105
|
90 100 110
....*....|....*....|....*....|
gi 126090770 98 SLERSLQKLQFDYVDLYLIHYPMALKPGEE 127
Cdd:cd19151 106 SLDQSLKRMGLDYVDIFYHHRPDPETPLEE 135
|
|
| |
