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Conserved domains on  [gi|21312892|ref|NP_083417|]
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bax inhibitor 1-like isoform b [Mus musculus]

Protein Classification

protein lifeguard( domain architecture ID 10179627)

protein lifeguard similar to human protein lifeguard 2, an antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis, and regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 84-301 1.82e-91

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


:

Pssm-ID: 198410  Cd Length: 217  Bit Score: 270.57  E-value: 1.82e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892  84 PFENTSIRNDFIMKVFVVLSIQLFITAVIIGIFVFCEPVRKWVIAKPWFLYALLPAVMILIFVLACCRDIRRQVPANYIL 163
Cdd:cd10428   1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892 164 LAFFTILEGLLLGSLSVFYRAEEILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLIYGIIALVIRSYWLHL 243
Cdd:cd10428  81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21312892 244 VYSALGTLLFSIYLVMDVQMMVGGRyHYEINPEEYIFAALNIYVDIISLFIFILDLIG 301
Cdd:cd10428 161 VYASLGALLFSLYLAVDTQLLMGGR-KYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 84-301 1.82e-91

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 270.57  E-value: 1.82e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892  84 PFENTSIRNDFIMKVFVVLSIQLFITAVIIGIFVFCEPVRKWVIAKPWFLYALLPAVMILIFVLACCRDIRRQVPANYIL 163
Cdd:cd10428   1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892 164 LAFFTILEGLLLGSLSVFYRAEEILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLIYGIIALVIRSYWLHL 243
Cdd:cd10428  81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21312892 244 VYSALGTLLFSIYLVMDVQMMVGGRyHYEINPEEYIFAALNIYVDIISLFIFILDLIG 301
Cdd:cd10428 161 VYASLGALLFSLYLAVDTQLLMGGR-KYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 92-297 4.36e-28

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 107.65  E-value: 4.36e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892    92 NDFIMKVFVVLSIQLFITAVIIGIFVFCEPVRKWVIAKPWFLYALLPAVMILIFVLACCRDIRRQVPANYILLAFFTILE 171
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYSSNVALLLLLAFTLLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892   172 GLLLGSLSVFYRAEEILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLIYGIIALVIRSYWLHLVYSALGTL 251
Cdd:pfam01027  81 GLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGVL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 21312892   252 LFSIYLVMDVQMMVGGRYHYEinPEEYIFAALNIYVDIISLFIFIL 297
Cdd:pfam01027 161 LFSGFILYDTQRIIKRYGEYG--DYDAILAALSLYLDFINLFLSLL 204
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 91-302 4.71e-23

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 94.86  E-value: 4.71e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892  91 RNDFIMKVFVVLSIQLFITAVIIGIFVFCEPVRKWVIAKPWFLYALLPAVMILIFVLACcRDIRRQVPANYILLAFFTIL 170
Cdd:COG0670  19 LRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSK-LANRANSAAALALLFAYTAL 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892 171 EGLLLGSLSVFY----RAEEILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLIYGIIALVIRSYWLHLVYS 246
Cdd:COG0670  98 MGLTLSPILLVYtglsGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAIS 177

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21312892 247 ALGTLLFSIYLVMDVQMMVGGryhYEINpEEYIFAALNIYVDIISLFIFILDLIGR 302
Cdd:COG0670 178 VAGVLLFSGLTLYDTQRIKHG---YETN-KQYIMAALSLYLDFINLFLSLLRLLGG 229
PRK10447 PRK10447
FtsH protease modulator YccA;
187-301 9.40e-04

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 39.82  E-value: 9.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892  187 ILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLIYGIIALVIRSYWLHLVYSALGTLLFSIYLVMDVQMMVG 266
Cdd:PRK10447 106 IALALGGTALVFFCCSAYVLTTRKDMSFLGGMLMAGIVVVLIGMVANIFLQLPALHLAISAVFILISSGAILFETSNIIH 185

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 21312892  267 GRyhyEINpeeYIFAALNIYVDIISLFIFILDLIG 301
Cdd:PRK10447 186 GG---ETN---YIRATVSLYVSLYNIFVSLLSILG 214
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 84-301 1.82e-91

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 270.57  E-value: 1.82e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892  84 PFENTSIRNDFIMKVFVVLSIQLFITAVIIGIFVFCEPVRKWVIAKPWFLYALLPAVMILIFVLACCRDIRRQVPANYIL 163
Cdd:cd10428   1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892 164 LAFFTILEGLLLGSLSVFYRAEEILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLIYGIIALVIRSYWLHL 243
Cdd:cd10428  81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21312892 244 VYSALGTLLFSIYLVMDVQMMVGGRyHYEINPEEYIFAALNIYVDIISLFIFILDLIG 301
Cdd:cd10428 161 VYASLGALLFSLYLAVDTQLLMGGR-KYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 87-297 2.64e-44

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 150.83  E-value: 2.64e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892  87 NTSIRNDFIMKVFVVLSIQLFITAVIIGIFVFCEPVRKWVIAKPWFLYALLPAVMILIFVLACcrdIRRQVPANYILLAF 166
Cdd:cd10429  23 EPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPWLFLISLIGSLILLIALYW---KRHSHPVNLILLSL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892 167 FTILEGLLLGSLSVFYRAEEILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLIYGIIA-LVIRSYWLHLVY 245
Cdd:cd10429 100 FTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALILLALIFqFFPYSPTFELVY 179

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 21312892 246 SALGTLLFSIYLVMDVQMMVgGRYHyeinPEEYIFAALNIYVDIISLFIFIL 297
Cdd:cd10429 180 AGLGALLFSGYIVYDTQLIM-KRLS----PDEYILAAISLYLDIINLFLSIL 226
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 90-301 4.73e-31

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 115.20  E-value: 4.73e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892  90 IRNDFIMKVFVVLSIQLFITAVIIGIFVFCEPVrkwviaKPWFLYALLPAVMiLIFVLACCRDIRRQVPANYILLAFFTI 169
Cdd:cd06181   1 STKDFLRKVYMILALQLLLTAATATAFTVCDPG------WYWSPALMGLLTS-MLALMATAAMIRAKMPVNLILLFGFTG 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892 170 LEGLLLGSLSVFYRAEEILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLIYGIIALVIRSYWLHLVYSALG 249
Cdd:cd06181  74 LMGYVVGPLLFFYGPTILLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVAAAVG 153

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 21312892 250 TLLFSIYLVMDVQMMVGGRyhyEINPEEYIFAALNIYVDIISLFIFILDLIG 301
Cdd:cd06181 154 LVLFCGFLLYDTQLIIHKA---EVGPEDYINACISLYLDIINIFIRLLTILA 202
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 92-297 4.36e-28

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 107.65  E-value: 4.36e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892    92 NDFIMKVFVVLSIQLFITAVIIGIFVFCEPVRKWVIAKPWFLYALLPAVMILIFVLACCRDIRRQVPANYILLAFFTILE 171
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYSSNVALLLLLAFTLLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892   172 GLLLGSLSVFYRAEEILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLIYGIIALVIRSYWLHLVYSALGTL 251
Cdd:pfam01027  81 GLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGVL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 21312892   252 LFSIYLVMDVQMMVGGRYHYEinPEEYIFAALNIYVDIISLFIFIL 297
Cdd:pfam01027 161 LFSGFILYDTQRIIKRYGEYG--DYDAILAALSLYLDFINLFLSLL 204
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 91-302 4.71e-23

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 94.86  E-value: 4.71e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892  91 RNDFIMKVFVVLSIQLFITAVIIGIFVFCEPVRKWVIAKPWFLYALLPAVMILIFVLACcRDIRRQVPANYILLAFFTIL 170
Cdd:COG0670  19 LRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSK-LANRANSAAALALLFAYTAL 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892 171 EGLLLGSLSVFY----RAEEILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLIYGIIALVIRSYWLHLVYS 246
Cdd:COG0670  98 MGLTLSPILLVYtglsGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAIS 177

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21312892 247 ALGTLLFSIYLVMDVQMMVGGryhYEINpEEYIFAALNIYVDIISLFIFILDLIGR 302
Cdd:COG0670 178 VAGVLLFSGLTLYDTQRIKHG---YETN-KQYIMAALSLYLDFINLFLSLLRLLGG 229
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 91-301 1.16e-18

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 82.22  E-value: 1.16e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892  91 RNDFIMKVFVVLSIQLFITAVIIGIFVFCEPVRKWVIAKPWFLYALLPavMILIFVLACCRDiRRQVPANYILLAFFTIL 170
Cdd:cd10432   2 LRSFMKKVYGLMAAGLLLTAVGAYVGASTPALLLIAGSPLMWVLLIAE--LALVFGLSFRIN-KMSVATALPLFFAFAAL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892 171 EGLLLGSLSVFYRAEEILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLIYGIIALVIRSYWLHLVYSALGT 250
Cdd:cd10432  79 TGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISAIGV 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 21312892 251 LLFSIYLVMDVQM--MVGGRYHYEINPEEYIFAALNIYVDIISLFIFILDLIG 301
Cdd:cd10432 159 LIFSGLIAYDTQRikRMYEAGGGESGYKDAIMGALSLYLDFINLFLFLLRLFG 211
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 184-301 1.21e-11

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 62.60  E-value: 1.21e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892 184 AEEILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLIYGIIALVIRSYWLHLVYSALGTLLFSIYLVMDVQM 263
Cdd:cd10433  90 GQIIMTALGGTAAIFFGLSAYALTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAAFVLFSSGFILYDTSR 169

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 21312892 264 MVGGRyhyEINpeeYIFAALNIYVDIISLFIFILDLIG 301
Cdd:cd10433 170 IIHGG---ETN---YIMATVSLYVSIYNLFVSLLNLLG 201
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 193-297 9.36e-07

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 48.76  E-value: 9.36e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892 193 ATTMVTLVLTLFALQTK-WDFTLLNGVMFVFTSVLLIYGIIALVIRSYWLHLVYSALGTLLFSIYLVMDVQMMVGGRYHY 271
Cdd:cd10430 103 GTAVIFACFSLAALLAKrREYLYLGGLLSSALSILLLVSLANIFGGSKFLFQAELYLGLLVFCGFVLFDTQMIIEKAENG 182

                        90       100
                ....*....|....*....|....*.
gi 21312892 272 EinpEEYIFAALNIYVDIISLFIFIL 297
Cdd:cd10430 183 D---RDYIWHALDLFVDFVALFRRLL 205
PRK10447 PRK10447
FtsH protease modulator YccA;
187-301 9.40e-04

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 39.82  E-value: 9.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312892  187 ILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLIYGIIALVIRSYWLHLVYSALGTLLFSIYLVMDVQMMVG 266
Cdd:PRK10447 106 IALALGGTALVFFCCSAYVLTTRKDMSFLGGMLMAGIVVVLIGMVANIFLQLPALHLAISAVFILISSGAILFETSNIIH 185

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 21312892  267 GRyhyEINpeeYIFAALNIYVDIISLFIFILDLIG 301
Cdd:PRK10447 186 GG---ETN---YIRATVSLYVSLYNIFVSLLSILG 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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