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Conserved domains on  [gi|21312060|ref|NP_082899|]
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cystatin-M precursor [Mus musculus]

Protein Classification

cystatin family protein( domain architecture ID 11249387)

cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 59-147 2.19e-22

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 85.17  E-value: 2.19e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312060     59 YNMGSDSLYYFRDTKVIDAKYQLVAGIKYYLTLDIESTECRKTRVsgehmDLTTCPLAAGGQQEklrCNFELLEVPWKNT 138
Cdd:smart00043  27 YNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSV-----DLENCPFLDQGEKF---CTAKVWEKPWENK 98


                   ....*....
gi 21312060    139 TQLLKHDCV 147
Cdd:smart00043  99 IKLVEFKCT 107
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 59-147 2.19e-22

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 85.17  E-value: 2.19e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312060     59 YNMGSDSLYYFRDTKVIDAKYQLVAGIKYYLTLDIESTECRKTRVsgehmDLTTCPLAAGGQQEklrCNFELLEVPWKNT 138
Cdd:smart00043  27 YNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSV-----DLENCPFLDQGEKF---CTAKVWEKPWENK 98


                   ....*....
gi 21312060    139 TQLLKHDCV 147
Cdd:smart00043  99 IKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 36-146 1.08e-16

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 70.58  E-value: 1.08e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312060  36 GERQNLSPTDPRVQKAAQAAVASYNMGSDSLYYfRDTKVIDAKYQLVAGIKYYLTLDIESTECRKTRVsgehmDLTTCPL 115
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYL-EFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSV-----PLDCPDC 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 21312060 116 AAGGQQEKLRCNFELLEVPWKNTTQLLKHDC 146
Cdd:cd00042  75 KLLEEGKKKFCTAKVWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 59-135 1.76e-08

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 48.87  E-value: 1.76e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21312060    59 YNMGSDSlYYFRDTKVIDAKYQLVAGIKYYLTLDIESTECRKtrvsgeHM-DLTTCPLAAggQQEKLRCNFELLEVPW 135
Cdd:pfam00031  24 YNAKTDN-YYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK------SKkLLEDCPLLD--EKWLGLCSAQVYKVPW 92
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 59-147 2.19e-22

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 85.17  E-value: 2.19e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312060     59 YNMGSDSLYYFRDTKVIDAKYQLVAGIKYYLTLDIESTECRKTRVsgehmDLTTCPLAAGGQQEklrCNFELLEVPWKNT 138
Cdd:smart00043  27 YNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSV-----DLENCPFLDQGEKF---CTAKVWEKPWENK 98


                   ....*....
gi 21312060    139 TQLLKHDCV 147
Cdd:smart00043  99 IKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 36-146 1.08e-16

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 70.58  E-value: 1.08e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312060  36 GERQNLSPTDPRVQKAAQAAVASYNMGSDSLYYfRDTKVIDAKYQLVAGIKYYLTLDIESTECRKTRVsgehmDLTTCPL 115
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYL-EFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSV-----PLDCPDC 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 21312060 116 AAGGQQEKLRCNFELLEVPWKNTTQLLKHDC 146
Cdd:cd00042  75 KLLEEGKKKFCTAKVWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 59-135 1.76e-08

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 48.87  E-value: 1.76e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21312060    59 YNMGSDSlYYFRDTKVIDAKYQLVAGIKYYLTLDIESTECRKtrvsgeHM-DLTTCPLAAggQQEKLRCNFELLEVPW 135
Cdd:pfam00031  24 YNAKTDN-YYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK------SKkLLEDCPLLD--EKWLGLCSAQVYKVPW 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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