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Conserved domains on  [gi|326807033|ref|NP_082277|]
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junctional sarcoplasmic reticulum protein 1 [Mus musculus]

Protein Classification

JSRP and PTZ00449 domain-containing protein( domain architecture ID 10633894)

JSRP and PTZ00449 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JSRP pfam15312
Junctional sarcoplasmic reticulum protein; JSRP, junctional sarcoplasmic reticulum protein 1, ...
 119-178 1.50e-14

Junctional sarcoplasmic reticulum protein; JSRP, junctional sarcoplasmic reticulum protein 1, or junctional-face membrane protein of 45 kDa homolog, is a family of eukaryotic proteins. The family is to the junctional face membrane of the skeletal muscle sarcoplasmic reticulum (SR); it colocalizes with its Ca2+-release channel (the ryanodine receptor), and interacts with calsequestrin and the skeletal-muscle dihydro-pyridine receptor Cav1. It is key for the functional expression of voltage-dependent Ca2+ channels.


:

Pssm-ID: 464637  Cd Length: 63  Bit Score: 67.47  E-value: 1.50e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 326807033  119 DDLPWGDLTLNKCLVLASLVALLGSALQLCRDAVAGEVVA---APHPWVPPSSPPKKEASPAP 178
Cdd:pfam15312   1 EELPWGDVTLNKCLVLASLVALLGSAFQLCHDAVRGERAApapAPEPWRPPSSLRKGPASPLP 63
PRK14954 super family cl33039
DNA polymerase III subunits gamma and tau; Provisional
 160-276 2.61e-04

DNA polymerase III subunits gamma and tau; Provisional


The actual alignment was detected with superfamily member PRK14954:

Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 42.62  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326807033 160 PHPWVPPSSPPKKEASPAPKPPVLVSPSGSPQPKPGPPQARmqdEPELPGSPEATETRverggsiSEASGEESVplgDRG 239
Cdd:PRK14954 398 DLPQPDRHPGPAKPEAPGARPAELPSPASAPTPEQQPPVAR---SAPLPPSPQASAPR-------NVASGKPGV---DLG 464

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 326807033 240 SQEKPRKEKPSKGEKLKKEKPRREKPRREDKSQVTGE 276
Cdd:PRK14954 465 SWQGKFMNFTRNGSRKQPVQASSSDAAQTGVFEGVAE 501
 
Name Accession Description Interval E-value
JSRP pfam15312
Junctional sarcoplasmic reticulum protein; JSRP, junctional sarcoplasmic reticulum protein 1, ...
 119-178 1.50e-14

Junctional sarcoplasmic reticulum protein; JSRP, junctional sarcoplasmic reticulum protein 1, or junctional-face membrane protein of 45 kDa homolog, is a family of eukaryotic proteins. The family is to the junctional face membrane of the skeletal muscle sarcoplasmic reticulum (SR); it colocalizes with its Ca2+-release channel (the ryanodine receptor), and interacts with calsequestrin and the skeletal-muscle dihydro-pyridine receptor Cav1. It is key for the functional expression of voltage-dependent Ca2+ channels.


Pssm-ID: 464637  Cd Length: 63  Bit Score: 67.47  E-value: 1.50e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 326807033  119 DDLPWGDLTLNKCLVLASLVALLGSALQLCRDAVAGEVVA---APHPWVPPSSPPKKEASPAP 178
Cdd:pfam15312   1 EELPWGDVTLNKCLVLASLVALLGSAFQLCHDAVRGERAApapAPEPWRPPSSLRKGPASPLP 63
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 160-276 2.61e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 42.62  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326807033 160 PHPWVPPSSPPKKEASPAPKPPVLVSPSGSPQPKPGPPQARmqdEPELPGSPEATETRverggsiSEASGEESVplgDRG 239
Cdd:PRK14954 398 DLPQPDRHPGPAKPEAPGARPAELPSPASAPTPEQQPPVAR---SAPLPPSPQASAPR-------NVASGKPGV---DLG 464

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 326807033 240 SQEKPRKEKPSKGEKLKKEKPRREKPRREDKSQVTGE 276
Cdd:PRK14954 465 SWQGKFMNFTRNGSRKQPVQASSSDAAQTGVFEGVAE 501
 
Name Accession Description Interval E-value
JSRP pfam15312
Junctional sarcoplasmic reticulum protein; JSRP, junctional sarcoplasmic reticulum protein 1, ...
 119-178 1.50e-14

Junctional sarcoplasmic reticulum protein; JSRP, junctional sarcoplasmic reticulum protein 1, or junctional-face membrane protein of 45 kDa homolog, is a family of eukaryotic proteins. The family is to the junctional face membrane of the skeletal muscle sarcoplasmic reticulum (SR); it colocalizes with its Ca2+-release channel (the ryanodine receptor), and interacts with calsequestrin and the skeletal-muscle dihydro-pyridine receptor Cav1. It is key for the functional expression of voltage-dependent Ca2+ channels.


Pssm-ID: 464637  Cd Length: 63  Bit Score: 67.47  E-value: 1.50e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 326807033  119 DDLPWGDLTLNKCLVLASLVALLGSALQLCRDAVAGEVVA---APHPWVPPSSPPKKEASPAP 178
Cdd:pfam15312   1 EELPWGDVTLNKCLVLASLVALLGSAFQLCHDAVRGERAApapAPEPWRPPSSLRKGPASPLP 63
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 160-276 2.61e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 42.62  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326807033 160 PHPWVPPSSPPKKEASPAPKPPVLVSPSGSPQPKPGPPQARmqdEPELPGSPEATETRverggsiSEASGEESVplgDRG 239
Cdd:PRK14954 398 DLPQPDRHPGPAKPEAPGARPAELPSPASAPTPEQQPPVAR---SAPLPPSPQASAPR-------NVASGKPGV---DLG 464

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 326807033 240 SQEKPRKEKPSKGEKLKKEKPRREKPRREDKSQVTGE 276
Cdd:PRK14954 465 SWQGKFMNFTRNGSRKQPVQASSSDAAQTGVFEGVAE 501
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
145-276 2.26e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 39.76  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326807033 145 LQLCRDAVAGEVVAAPHPWVPPSSPPKKEASPAPKPPVLVSPSGSPQ-----PKPGPPQARMQDEPelpgspeATETRVE 219
Cdd:PRK14971 357 IQLAQLTQKGDDASGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSqssaaAQPSAPQSATQPAG-------TPPTVSV 429

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 326807033 220 RGGSISEASGEESVPLGDRGSQEKPRKEKPSKgeKLKKEKPRREKPRREDKSQVTGE 276
Cdd:PRK14971 430 DPPAAVPVNPPSTAPQAVRPAQFKEEKKIPVS--KVSSLGPSTLRPIQEKAEQATGN 484
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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