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Conserved domains on  [gi|20149693|ref|NP_079405|]
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protein fuzzy homolog isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fuzzy cd21091
protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector ...
 12-416 0e+00

protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector that controls multiple cellular processes during development. PCP signalling is an evolutionarily conserved pathway by which directional information regarding polarized cell movement is provided to cells. The PCP signalling axis involves PCP core and PCP effector genes, which are activated consecutively to govern orientated cell migration and the establishment of cytoskeletal structures. Dishevelled (Dvl in mammals or Dsh in Drosophila) and Fuz (or fuzzy in Drosophila) are two representative PCP core and effector genes, respectively. PCP regulates mammalian nervous system development; Fuz-null mutant mice display neural tube defects due to failure of directional cell motility and cell fusion.


:

Pssm-ID: 411043 [Multi-domain]  Cd Length: 401  Bit Score: 559.27  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693  12 LLCLAASSGVPLFCRSSrggaPARQQLPFSVIGSLNGVHMFGQNLEVQLSSARTENTTVVWKSFHDSITLIVLSSEVGIS 91
Cdd:cd21091   1 LLCLTASSGVPLFCRSK----GGCKQLPFSVIGSLNGVHMFGENLDVQLTSTRTENTRVVWKVFHDSITLIVVSSEEGAS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693  92 ELRLERLLQMVFGAMVLLVGLEELTNIRNVERLKKDLRASYCLIDSFLGDSELIGDLTQCVDCVIPPEGSLLQEALSGFA 171
Cdd:cd21091  77 DLSLERLLENVFGAMVLLIGLDELTNITNVERLKKDLRACYPLIDSFLGNSELMGDLTQCVDCVIPPEGAALQECLDGFA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693 172 EAAGTTFVSLVVSGRVVAATEGWWRLGTPEAVLLPWLVGSLPPQTARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLLCG 251
Cdd:cd21091 157 EAAESTFGCLVVGGRVVVATEKWWRLDTQELVLLPWLVNSLPPTQARDYPVYLPHGSPTVPHRLLTFQLLSGVEVCVLCG 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693 252 PSPPLSQLYPQLLERWWQPLLDPLRACLPLGPRALPSGFPLHTDILGLLLLHLELKRCLFTVEPLGDKE-----PSPEQR 326
Cdd:cd21091 237 PEPSLQQVQRELVERFWRPLLDPLRACLRLVPRALPLGVPLDSGVLGLLLINRETRRSLFTVQPSEDSArkrmsLSDEQR 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693 327 RRLLRNFYTLVTSTHFPPEPGPPEKTEDEVY-QAQLPRACYLVLGTeepgtgVRLVALQLGLRRLLLLLSPQSPTHGLRS 405
Cdd:cd21091 317 RDALRSFYTLVADRYFPPETGPDENTTTTVHpFSHLPRECYVVTKS------HKCYAIQTSQYQLFLLFSPAVPTHALRS 390

                       410
                ....*....|.
gi 20149693 406 LATHTLHALTP 416
Cdd:cd21091 391 LATRTLQALTK 401
 
Name Accession Description Interval E-value
Fuzzy cd21091
protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector ...
 12-416 0e+00

protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector that controls multiple cellular processes during development. PCP signalling is an evolutionarily conserved pathway by which directional information regarding polarized cell movement is provided to cells. The PCP signalling axis involves PCP core and PCP effector genes, which are activated consecutively to govern orientated cell migration and the establishment of cytoskeletal structures. Dishevelled (Dvl in mammals or Dsh in Drosophila) and Fuz (or fuzzy in Drosophila) are two representative PCP core and effector genes, respectively. PCP regulates mammalian nervous system development; Fuz-null mutant mice display neural tube defects due to failure of directional cell motility and cell fusion.


Pssm-ID: 411043 [Multi-domain]  Cd Length: 401  Bit Score: 559.27  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693  12 LLCLAASSGVPLFCRSSrggaPARQQLPFSVIGSLNGVHMFGQNLEVQLSSARTENTTVVWKSFHDSITLIVLSSEVGIS 91
Cdd:cd21091   1 LLCLTASSGVPLFCRSK----GGCKQLPFSVIGSLNGVHMFGENLDVQLTSTRTENTRVVWKVFHDSITLIVVSSEEGAS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693  92 ELRLERLLQMVFGAMVLLVGLEELTNIRNVERLKKDLRASYCLIDSFLGDSELIGDLTQCVDCVIPPEGSLLQEALSGFA 171
Cdd:cd21091  77 DLSLERLLENVFGAMVLLIGLDELTNITNVERLKKDLRACYPLIDSFLGNSELMGDLTQCVDCVIPPEGAALQECLDGFA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693 172 EAAGTTFVSLVVSGRVVAATEGWWRLGTPEAVLLPWLVGSLPPQTARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLLCG 251
Cdd:cd21091 157 EAAESTFGCLVVGGRVVVATEKWWRLDTQELVLLPWLVNSLPPTQARDYPVYLPHGSPTVPHRLLTFQLLSGVEVCVLCG 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693 252 PSPPLSQLYPQLLERWWQPLLDPLRACLPLGPRALPSGFPLHTDILGLLLLHLELKRCLFTVEPLGDKE-----PSPEQR 326
Cdd:cd21091 237 PEPSLQQVQRELVERFWRPLLDPLRACLRLVPRALPLGVPLDSGVLGLLLINRETRRSLFTVQPSEDSArkrmsLSDEQR 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693 327 RRLLRNFYTLVTSTHFPPEPGPPEKTEDEVY-QAQLPRACYLVLGTeepgtgVRLVALQLGLRRLLLLLSPQSPTHGLRS 405
Cdd:cd21091 317 RDALRSFYTLVADRYFPPETGPDENTTTTVHpFSHLPRECYVVTKS------HKCYAIQTSQYQLFLLFSPAVPTHALRS 390

                       410
                ....*....|.
gi 20149693 406 LATHTLHALTP 416
Cdd:cd21091 391 LATRTLQALTK 401
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 11-138 1.07e-38

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 135.41  E-value: 1.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693    11 HLLCLAaSSGVPLFCRSSRggapARQQLPFSVIGSLNGVHMFGQNLEVQLSSARTENTTVVWKSFHdSITLIVLSSEvGI 90
Cdd:pfam19036   2 HLLILS-SAGKPIFTRYGD----EDESLLFSLFGPLNGSISFMQTQDDTLTSITCENTKVVFLEKG-PLLLVAISRS-GE 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 20149693    91 SELRLERLLQMVFGAMVLLVGLEELTNIRN---VERLKKDLRASYCLIDSF 138
Cdd:pfam19036  75 SEQQLRRQLDVVYNQILSLLGLPQLTRIFNrrpNEDLRRLLSGLEDLLDSL 125
 
Name Accession Description Interval E-value
Fuzzy cd21091
protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector ...
 12-416 0e+00

protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector that controls multiple cellular processes during development. PCP signalling is an evolutionarily conserved pathway by which directional information regarding polarized cell movement is provided to cells. The PCP signalling axis involves PCP core and PCP effector genes, which are activated consecutively to govern orientated cell migration and the establishment of cytoskeletal structures. Dishevelled (Dvl in mammals or Dsh in Drosophila) and Fuz (or fuzzy in Drosophila) are two representative PCP core and effector genes, respectively. PCP regulates mammalian nervous system development; Fuz-null mutant mice display neural tube defects due to failure of directional cell motility and cell fusion.


Pssm-ID: 411043 [Multi-domain]  Cd Length: 401  Bit Score: 559.27  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693  12 LLCLAASSGVPLFCRSSrggaPARQQLPFSVIGSLNGVHMFGQNLEVQLSSARTENTTVVWKSFHDSITLIVLSSEVGIS 91
Cdd:cd21091   1 LLCLTASSGVPLFCRSK----GGCKQLPFSVIGSLNGVHMFGENLDVQLTSTRTENTRVVWKVFHDSITLIVVSSEEGAS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693  92 ELRLERLLQMVFGAMVLLVGLEELTNIRNVERLKKDLRASYCLIDSFLGDSELIGDLTQCVDCVIPPEGSLLQEALSGFA 171
Cdd:cd21091  77 DLSLERLLENVFGAMVLLIGLDELTNITNVERLKKDLRACYPLIDSFLGNSELMGDLTQCVDCVIPPEGAALQECLDGFA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693 172 EAAGTTFVSLVVSGRVVAATEGWWRLGTPEAVLLPWLVGSLPPQTARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLLCG 251
Cdd:cd21091 157 EAAESTFGCLVVGGRVVVATEKWWRLDTQELVLLPWLVNSLPPTQARDYPVYLPHGSPTVPHRLLTFQLLSGVEVCVLCG 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693 252 PSPPLSQLYPQLLERWWQPLLDPLRACLPLGPRALPSGFPLHTDILGLLLLHLELKRCLFTVEPLGDKE-----PSPEQR 326
Cdd:cd21091 237 PEPSLQQVQRELVERFWRPLLDPLRACLRLVPRALPLGVPLDSGVLGLLLINRETRRSLFTVQPSEDSArkrmsLSDEQR 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693 327 RRLLRNFYTLVTSTHFPPEPGPPEKTEDEVY-QAQLPRACYLVLGTeepgtgVRLVALQLGLRRLLLLLSPQSPTHGLRS 405
Cdd:cd21091 317 RDALRSFYTLVADRYFPPETGPDENTTTTVHpFSHLPRECYVVTKS------HKCYAIQTSQYQLFLLFSPAVPTHALRS 390

                       410
                ....*....|.
gi 20149693 406 LATHTLHALTP 416
Cdd:cd21091 391 LATRTLQALTK 401
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 11-138 1.07e-38

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 135.41  E-value: 1.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693    11 HLLCLAaSSGVPLFCRSSRggapARQQLPFSVIGSLNGVHMFGQNLEVQLSSARTENTTVVWKSFHdSITLIVLSSEvGI 90
Cdd:pfam19036   2 HLLILS-SAGKPIFTRYGD----EDESLLFSLFGPLNGSISFMQTQDDTLTSITCENTKVVFLEKG-PLLLVAISRS-GE 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 20149693    91 SELRLERLLQMVFGAMVLLVGLEELTNIRN---VERLKKDLRASYCLIDSF 138
Cdd:pfam19036  75 SEQQLRRQLDVVYNQILSLLGLPQLTRIFNrrpNEDLRRLLSGLEDLLDSL 125
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 174-269 1.42e-15

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 71.88  E-value: 1.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149693   174 AGTTFVSLVVSGRVVAATEGWW-RLGTPEAVLLPWLVGSLPPQT--ARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLLC 250
Cdd:pfam19037   1 KSLLFALLLVGGKLVAAYRPRWaSLHPSDLLLLFLLVQSSSPFKslELWIPICLPKFNPGVLHRYISFLGDINLCLLLLS 80

                          90
                  ....*....|....*....
gi 20149693   251 GPSPPLsQLYPQLLERWWQ 269
Cdd:pfam19037  81 GDKPAF-FELSLLDDRFWL 98
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 307-372 2.33e-04

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 40.32  E-value: 2.33e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20149693   307 KRCLFTVEPLgDKEPSPEQRRRLLRNFYTLVTSTHFPPepgppektedevyqAQLPRACYLVLGTE 372
Cdd:pfam19038  13 VQFTAPSLPT-DPPYTTEQRRRRLRSFYQLLHSTLHSP--------------SGPLKLLYKVSDYE 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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