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Conserved domains on  [gi|168229156|ref|NP_078804|]
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NF-kappa-B-activating protein [Homo sapiens]

Protein Classification

NKAP family protein( domain architecture ID 19510766)

NKAP (NF-kappa-B-activating protein) family protein, similar to human NKAP-like protein (NKAPL) that functions as a transcriptional repressor of Notch-mediated signaling

Gene Ontology:  GO:0003682|GO:0003676

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nkap_C pfam06047
NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in ...
 306-405 3.50e-59

NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. Functional studies in Nkap indicate that this domain is the HDAC3 binding domain and is required for transcriptional repression. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition of functional competency.


:

Pssm-ID: 461812  Cd Length: 102  Bit Score: 187.84  E-value: 3.50e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229156  306 PLNYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIASFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASF 385
Cdd:pfam06047   1 ERNYGGALLPGEGAAMAQYVQEGKRIPRRGEIGLTSEEIEKFEDLGYVMSGSRHRRMNAVRIRKENQVYSAEEKRALALL 80

                          90       100
                  ....*....|....*....|
gi 168229156  386 NQEERRKRENKILASFREMV 405
Cdd:pfam06047  81 NKEERAKRENEIISQFRELV 100
NKAP super family cl24308
NF-kappa-B-activating protein; NKAP is a family of eukaryotic proteins that interacts with ...
 120-176 4.85e-04

NF-kappa-B-activating protein; NKAP is a family of eukaryotic proteins that interacts with NF-kappa-B. It is a nuclear regulator of TNF- and IL-1-induced NF-kappa-B activation. NKAP does not interact with RIP in mammalian cells family is often found in association with pfam06047.


The actual alignment was detected with superfamily member pfam15692:

Pssm-ID: 464805  Cd Length: 84  Bit Score: 38.59  E-value: 4.85e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 168229156  120 KEREESLRQKRLSERERigelGAPEVWGLS------PKNPEPDSDEHTPVEDEEPKKSTTSAS 176
Cdd:pfam15692   5 EARRQWYWNRKLYEREA----GDPDRWGHSgykelyPEEFESDSDEHTGVEGDGRRRRSKKSS 63
 
Name Accession Description Interval E-value
Nkap_C pfam06047
NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in ...
 306-405 3.50e-59

NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. Functional studies in Nkap indicate that this domain is the HDAC3 binding domain and is required for transcriptional repression. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition of functional competency.


Pssm-ID: 461812  Cd Length: 102  Bit Score: 187.84  E-value: 3.50e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229156  306 PLNYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIASFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASF 385
Cdd:pfam06047   1 ERNYGGALLPGEGAAMAQYVQEGKRIPRRGEIGLTSEEIEKFEDLGYVMSGSRHRRMNAVRIRKENQVYSAEEKRALALL 80

                          90       100
                  ....*....|....*....|
gi 168229156  386 NQEERRKRENKILASFREMV 405
Cdd:pfam06047  81 NKEERAKRENEIISQFRELV 100
NKAP pfam15692
NF-kappa-B-activating protein; NKAP is a family of eukaryotic proteins that interacts with ...
 120-176 4.85e-04

NF-kappa-B-activating protein; NKAP is a family of eukaryotic proteins that interacts with NF-kappa-B. It is a nuclear regulator of TNF- and IL-1-induced NF-kappa-B activation. NKAP does not interact with RIP in mammalian cells family is often found in association with pfam06047.


Pssm-ID: 464805  Cd Length: 84  Bit Score: 38.59  E-value: 4.85e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 168229156  120 KEREESLRQKRLSERERigelGAPEVWGLS------PKNPEPDSDEHTPVEDEEPKKSTTSAS 176
Cdd:pfam15692   5 EARRQWYWNRKLYEREA----GDPDRWGHSgykelyPEEFESDSDEHTGVEGDGRRRRSKKSS 63
 
Name Accession Description Interval E-value
Nkap_C pfam06047
NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in ...
 306-405 3.50e-59

NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. Functional studies in Nkap indicate that this domain is the HDAC3 binding domain and is required for transcriptional repression. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition of functional competency.


Pssm-ID: 461812  Cd Length: 102  Bit Score: 187.84  E-value: 3.50e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229156  306 PLNYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIASFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASF 385
Cdd:pfam06047   1 ERNYGGALLPGEGAAMAQYVQEGKRIPRRGEIGLTSEEIEKFEDLGYVMSGSRHRRMNAVRIRKENQVYSAEEKRALALL 80

                          90       100
                  ....*....|....*....|
gi 168229156  386 NQEERRKRENKILASFREMV 405
Cdd:pfam06047  81 NKEERAKRENEIISQFRELV 100
NKAP pfam15692
NF-kappa-B-activating protein; NKAP is a family of eukaryotic proteins that interacts with ...
 120-176 4.85e-04

NF-kappa-B-activating protein; NKAP is a family of eukaryotic proteins that interacts with NF-kappa-B. It is a nuclear regulator of TNF- and IL-1-induced NF-kappa-B activation. NKAP does not interact with RIP in mammalian cells family is often found in association with pfam06047.


Pssm-ID: 464805  Cd Length: 84  Bit Score: 38.59  E-value: 4.85e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 168229156  120 KEREESLRQKRLSERERigelGAPEVWGLS------PKNPEPDSDEHTPVEDEEPKKSTTSAS 176
Cdd:pfam15692   5 EARRQWYWNRKLYEREA----GDPDRWGHSgykelyPEEFESDSDEHTGVEGDGRRRRSKKSS 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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