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Conserved domains on  [gi|12383064|ref|NP_073734|]
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fibronectin type III domain-containing protein 4 precursor [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein with an immunoglobulin-like (Ig-like) fold similar to mammalian interleukin-9 and interleukin-21 receptors, and to immunoglobulin I-set domains (antibody intermediate domain-like) such as myomesin, contactin, neural cell adhesion molecule 1, roundabout homologs, and cell adhesion molecules, among others

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  9541533|7833045|8981327|7932691

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 47-137 1.02e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 1.02e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12383064  47 PPSPVNVTVTHLRANSATVSWDVPE--GNIVIGYSISQQRQNGPGQRVIREVNTTTRACALWGLAEDSDYTVQVRSIGLR 124
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEddGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                        90
                ....*....|...
gi 12383064 125 GESPPGPRVHFRT 137
Cdd:cd00063  81 GESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 47-137 1.02e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 1.02e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12383064  47 PPSPVNVTVTHLRANSATVSWDVPE--GNIVIGYSISQQRQNGPGQRVIREVNTTTRACALWGLAEDSDYTVQVRSIGLR 124
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEddGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                        90
                ....*....|...
gi 12383064 125 GESPPGPRVHFRT 137
Cdd:cd00063  81 GESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 47-127 3.15e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.62  E-value: 3.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12383064     47 PPSPVNVTVTHLRANSATVSWDVPEGNIVIGYSISQQRQNGPGQRVIREVNTTTRA--CALWGLAEDSDYTVQVRSIGLR 124
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 12383064    125 GES 127
Cdd:smart00060  81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
48-129 8.76e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.26  E-value: 8.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12383064    48 PSPVNVTVTHLRANSATVSWDVPE--GNIVIGYSISQQRQNGPGQRVIREVNTTTRACALWGLAEDSDYTVQVRSIGLRG 125
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....
gi 12383064   126 ESPP 129
Cdd:pfam00041  81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
47-129 1.85e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.22  E-value: 1.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12383064  47 PPSPVNVTVTHLRANSATVSWDVPEGNIVIGYSISQQRQNGPGQRVIREVNTT----TracalwGLAEDSDYTVQVRSIG 122
Cdd:COG3401 233 PSAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVATVTTTsytdT------GLTNGTTYYYRVTAVD 306


                ....*...
gi 12383064 123 LRG-ESPP 129
Cdd:COG3401 307 AAGnESAP 314
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 47-137 1.02e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 1.02e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12383064  47 PPSPVNVTVTHLRANSATVSWDVPE--GNIVIGYSISQQRQNGPGQRVIREVNTTTRACALWGLAEDSDYTVQVRSIGLR 124
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEddGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                        90
                ....*....|...
gi 12383064 125 GESPPGPRVHFRT 137
Cdd:cd00063  81 GESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 47-127 3.15e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.62  E-value: 3.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12383064     47 PPSPVNVTVTHLRANSATVSWDVPEGNIVIGYSISQQRQNGPGQRVIREVNTTTRA--CALWGLAEDSDYTVQVRSIGLR 124
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 12383064    125 GES 127
Cdd:smart00060  81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
48-129 8.76e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.26  E-value: 8.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12383064    48 PSPVNVTVTHLRANSATVSWDVPE--GNIVIGYSISQQRQNGPGQRVIREVNTTTRACALWGLAEDSDYTVQVRSIGLRG 125
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....
gi 12383064   126 ESPP 129
Cdd:pfam00041  81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
47-129 1.85e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.22  E-value: 1.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12383064  47 PPSPVNVTVTHLRANSATVSWDVPEGNIVIGYSISQQRQNGPGQRVIREVNTT----TracalwGLAEDSDYTVQVRSIG 122
Cdd:COG3401 233 PSAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVATVTTTsytdT------GLTNGTTYYYRVTAVD 306


                ....*...
gi 12383064 123 LRG-ESPP 129
Cdd:COG3401 307 AAGnESAP 314
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
47-161 9.67e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 36.85  E-value: 9.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12383064  47 PPSPVNVTVTH--------LRANSATVSWDVPEGNIVigYSISQQRQNGPGQRVIRevnTTTRACALWGLAeDSDYTVQV 118
Cdd:COG4733 530 QWPPVNVTTSEslsvvaqgTAVTTLTVSWDAPAGAVA--YEVEWRRDDGNWVSVPR---TSGTSFEVPGIY-AGDYEVRV 603

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 12383064 119 RSIGLRG-ESPPGPRVHFrTLKGSDRLPSNsssPGDITVEGLDG 161
Cdd:COG4733 604 RAINALGvSSAWAASSET-TVTGKTAPPPA---PTGLTATGGLG 643
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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