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Conserved domains on  [gi|31543741|ref|NP_071308|]
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high affinity choline transporter 1 [Mus musculus]

Protein Classification

sodium:solute symporter family protein( domain architecture ID 10183701)

sodium:solute symporter family protein similar to human high-affinity choline transporter 1 (CHT), also called solute carrier family 5 member 7, which is a sodium ion- and chloride ion-dependent transmembrane transporter that imports choline from the extracellular space into the neuron

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
8-495 0e+00

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


:

Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 582.95  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTKNSGNpeerseaIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAwAQA 87
Cdd:cd11474   1 LIGVILYYLLILGIGLWASRRVKSSED-------FLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGV-AQD 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIV 167
Cdd:cd11474  73 PFGYALCLILGGLFFAKPMRRMGLLTLGDFFRQRYGRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPVETGILI 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 168 SALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIG-FTAVHAKYQSPWLGTIEsvEVYTWLDNFLL 246
Cdd:cd11474 153 SAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDIAsAAAAGKLRFFPWLGTKS--DWLIWIDAWLT 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 247 LMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTDWNQTAYGypdpkTKEEADMILPIVLQY 326
Cdd:cd11474 231 LGLGSIPQQDVFQRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYG-----LEEDAQLILPLLLQY 305
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 327 LCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLW 406
Cdd:cd11474 306 LTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATLMALTVESIYGLV 385
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 407 YLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITGGEPYLYLQPLIfypgyysdknGIYNQRFPFKTLSMVT 486
Cdd:cd11474 386 ELASDLVLVGLFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGGELLLGLPADI----------PPQLQGFPFSTLAMVI 455

                ....*....
gi 31543741 487 SFFTNICVS 495
Cdd:cd11474 456 GSLLPLAVS 464
 
Name Accession Description Interval E-value
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
8-495 0e+00

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 582.95  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTKNSGNpeerseaIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAwAQA 87
Cdd:cd11474   1 LIGVILYYLLILGIGLWASRRVKSSED-------FLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGV-AQD 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIV 167
Cdd:cd11474  73 PFGYALCLILGGLFFAKPMRRMGLLTLGDFFRQRYGRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPVETGILI 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 168 SALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIG-FTAVHAKYQSPWLGTIEsvEVYTWLDNFLL 246
Cdd:cd11474 153 SAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDIAsAAAAGKLRFFPWLGTKS--DWLIWIDAWLT 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 247 LMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTDWNQTAYGypdpkTKEEADMILPIVLQY 326
Cdd:cd11474 231 LGLGSIPQQDVFQRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYG-----LEEDAQLILPLLLQY 305
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 327 LCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLW 406
Cdd:cd11474 306 LTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATLMALTVESIYGLV 385
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 407 YLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITGGEPYLYLQPLIfypgyysdknGIYNQRFPFKTLSMVT 486
Cdd:cd11474 386 ELASDLVLVGLFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGGELLLGLPADI----------PPQLQGFPFSTLAMVI 455

                ....*....
gi 31543741 487 SFFTNICVS 495
Cdd:cd11474 456 GSLLPLAVS 464
PutP COG0591
Na+/proline symporter [Amino acid transport and metabolism];
8-447 4.30e-78

Na+/proline symporter [Amino acid transport and metabolism];


Pssm-ID: 440356 [Multi-domain]  Cd Length: 476  Bit Score: 254.36  E-value: 4.30e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgCGLAWAQA 87
Cdd:COG0591   6 LIIIILYLLLLLGIGLYASRRTKSL-------EDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYA--YGLSALWY 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIV 167
Cdd:COG0591  77 ALGYALGALLLALFFAPRLRRLGALTIPEFLEKRFGRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILI 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 168 SALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAvtdiGFTAVHAKYQSP----WLGTIESVEVYTWLDN 243
Cdd:COG0591 157 GALIVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALG----GFGELFAALPAPgllsLFPGLGFTGWLAFLGL 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 244 FLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIgastdwnqtAYGYPDPKTKEEADMILPIV 323
Cdd:COG0591 233 FLAIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLL---------ARALFPDLPLADPDLALPLL 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 324 LQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTK-TV 402
Cdd:COG0591 304 ILELLPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLLALLLALLFPsSI 383
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*
gi 31543741 403 YGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRI 447
Cdd:COG0591 384 LDLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVL 428
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
45-442 6.97e-31

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 124.72  E-value: 6.97e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741    45 GGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGcgLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGK 124
Cdd:TIGR00813   1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYG--FAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   125 R----MGGLLFIPALMGEMfwAAAIFSAlGATISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLW 200
Cdd:TIGR00813  79 RilrgLSVLSLILYIFLYM--SVDLFSG-ALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   201 ISVPFALShpavtDIGFT-AVHAKYQSPWLGTIESVEVY-------TWLDNFLLLMLGGIPW-------QAYFQRVLSSS 265
Cdd:TIGR00813 156 ILPVFAFS-----EVGGLgTFVEKASQAAPTNPSPDDLYdffrdpsTSDLPWGAGVFGLPHValwywtnQVIVQRCLAAK 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   266 SATYAQVLSFLAAFGCLVMALPAICIGAIGAS--TDWNQTaygyPDPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAA 343
Cdd:TIGR00813 231 SAKHAKKGCLISGVLKLLPMFGAVLPGLIARAlyTDIDPA----LAGAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAA 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   344 VMSSADSSILSASSMFARNIYQLSFRQNAS-DKEIVWVMRITVLVFGASA-TAMALLTKTVYGLWYLSSDLVYIIIFPQL 421
Cdd:TIGR00813 307 VMSTLSSQLNSASTVFTMDLYKKIIRPNASgEKKIVMRGRIAVLVAAVIAgFVAAAQGGQVLQYVQEAFGGLGAPFLPVF 386
                         410       420
                  ....*....|....*....|.
gi 31543741   422 LCVLFIKGTNTYGAVAGYIFG 442
Cdd:TIGR00813 387 LLGIFWKRMNAKGALAGMIAG 407
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
43-442 3.68e-26

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 110.89  E-value: 3.68e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741    43 IVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgCGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIY 122
Cdd:pfam00474   2 FLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAA--SGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   123 GKR--------MGGLLFIPALMGEMFWAAAIFsalgatISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFC 194
Cdd:pfam00474  80 GGKrilvylsaLSLLLYFFTYMSVQIVGGARL------IELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   195 IFIGLWISVPFALSHPAvtdiGFTAVHAKYQS--PWLGTIESVEVYTWLDNFL-------LLMLGGIPWQAYFQRVLSSS 265
Cdd:pfam00474 154 MLFGTIILMIIVFHEVG----GYSSAVEKYMTadPNGVDLYTPDGLHILRDPLtglslwpGLVLGTTGLPHILQRCLAAK 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   266 SATYAqVLSFLAAFGCLVMALPaiciGAIGASTDWNQTAYGYPDPKTKE--EADMILPIVLQYLCPVYISFFGLGAVSAA 343
Cdd:pfam00474 230 DAKCI-RCGVLILTPMFIIVMP----GMISRGLFAIALAGANPRACGTVvgCSNIAYPTLAVKLGPPGLAGIMLAVMLAA 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   344 VMSSADSSILSASSMFARNIYQLSFRQN-ASDKEIVWVMRITVLVFGASATAMALLTKTVYGLWYLSSDLVYI--IIFPQ 420
Cdd:pfam00474 305 IMSTLTSQLLSSSSAFTHDLYKNIRRKAsATEKELVGRSRIIVLVVISLAILLAVQPAQMGIAFLVQLAFAGLgsAFLPV 384
                         410       420
                  ....*....|....*....|..
gi 31543741   421 LLCVLFIKGTNTYGAVAGYIFG 442
Cdd:pfam00474 385 ILLAIFWKRVNEQGALWGMIIG 406
PRK15419 PRK15419
sodium/proline symporter PutP;
1-396 6.40e-13

sodium/proline symporter PutP;


Pssm-ID: 185317  Cd Length: 502  Bit Score: 71.20  E-value: 6.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741    1 MSFHVEGLVAIILFYLLIFLVGIWAAWKTKNSGNpeerseaIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGC 80
Cdd:PRK15419   1 MAISTPMLVTFCVYIFGMILIGFIAWRSTKNFDD-------YILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGI 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   81 GLAWAQapIGYSLSLILGGLFFAKPMR-----SKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISV 155
Cdd:PRK15419  74 SESWIA--IGLTLGAWINWKLVAGRLRvhteyNNNALTLPDYFTGRFEDKSRILRIISALVILLFFTIYCASGIVAGARL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  156 I---IDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISvpfalshPAVTDIGFTAVHAKYQSPWLGTI 232
Cdd:PRK15419 152 FestFGMSYETALWAGAAATILYTFIGGFLAVSWTDTVQASLMIFALILT-------PVIVIISVGGFGDSLEVIKQKSI 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  233 ESVEVYTWLDNFLLLMLGGipWQ----------AYFQRVLSSSSATYAQVLSFLAAFGCLVmalPAICIGAIGASTDWNQ 302
Cdd:PRK15419 225 ENVDMLKGLNFVAIISLMG--WGlgyfgqphilARFMAADSHHSIVHARRISMTWMILCLA---GAVAVGFFGIAYFNEH 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  303 TAYGypdPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMR 382
Cdd:PRK15419 300 PAVA---GAVNQNAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGR 376
                        410
                 ....*....|....
gi 31543741  383 ITVLVFGASATAMA 396
Cdd:PRK15419 377 VMVLVVALVAIALA 390
 
Name Accession Description Interval E-value
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
8-495 0e+00

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 582.95  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTKNSGNpeerseaIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAwAQA 87
Cdd:cd11474   1 LIGVILYYLLILGIGLWASRRVKSSED-------FLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGV-AQD 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIV 167
Cdd:cd11474  73 PFGYALCLILGGLFFAKPMRRMGLLTLGDFFRQRYGRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPVETGILI 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 168 SALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIG-FTAVHAKYQSPWLGTIEsvEVYTWLDNFLL 246
Cdd:cd11474 153 SAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDIAsAAAAGKLRFFPWLGTKS--DWLIWIDAWLT 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 247 LMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTDWNQTAYGypdpkTKEEADMILPIVLQY 326
Cdd:cd11474 231 LGLGSIPQQDVFQRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYG-----LEEDAQLILPLLLQY 305
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 327 LCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLW 406
Cdd:cd11474 306 LTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATLMALTVESIYGLV 385
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 407 YLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITGGEPYLYLQPLIfypgyysdknGIYNQRFPFKTLSMVT 486
Cdd:cd11474 386 ELASDLVLVGLFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGGELLLGLPADI----------PPQLQGFPFSTLAMVI 455

                ....*....
gi 31543741 487 SFFTNICVS 495
Cdd:cd11474 456 GSLLPLAVS 464
PutP COG0591
Na+/proline symporter [Amino acid transport and metabolism];
8-447 4.30e-78

Na+/proline symporter [Amino acid transport and metabolism];


Pssm-ID: 440356 [Multi-domain]  Cd Length: 476  Bit Score: 254.36  E-value: 4.30e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgCGLAWAQA 87
Cdd:COG0591   6 LIIIILYLLLLLGIGLYASRRTKSL-------EDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYA--YGLSALWY 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIV 167
Cdd:COG0591  77 ALGYALGALLLALFFAPRLRRLGALTIPEFLEKRFGRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILI 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 168 SALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAvtdiGFTAVHAKYQSP----WLGTIESVEVYTWLDN 243
Cdd:COG0591 157 GALIVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALG----GFGELFAALPAPgllsLFPGLGFTGWLAFLGL 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 244 FLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIgastdwnqtAYGYPDPKTKEEADMILPIV 323
Cdd:COG0591 233 FLAIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLL---------ARALFPDLPLADPDLALPLL 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 324 LQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTK-TV 402
Cdd:COG0591 304 ILELLPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLLALLLALLFPsSI 383
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*
gi 31543741 403 YGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRI 447
Cdd:COG0591 384 LDLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVL 428
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
8-467 4.19e-76

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 248.62  E-value: 4.19e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAQa 87
Cdd:cd10322   3 LIIVVVYLALLLGIGLYASKKVKSS-------EDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYI- 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  88 pIGYSLSLILGGLFFAKPMRSKGYVTMLD-PFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVI 166
Cdd:cd10322  75 -LGAALGALLLALFLAPRLRRLGKTTIPEtILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVI 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 167 VSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIGFTAVHAKYQSPWLGTIESVEVYTWLDNFLL 246
Cdd:cd10322 154 IAAVIVILYTVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGGGFSALAAALPALLLALGPGGGLGWSTILSLILL 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 247 LMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTdwnqtaygYPDPktkEEADMILPIVLQY 326
Cdd:cd10322 234 TGLGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARAL--------FPDL---ENPDLALPTLINS 302
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 327 LCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLW 406
Cdd:cd10322 303 LLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASDKKLLRVSRIAVVVVGVLALLLALLPPSILLLL 382
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31543741 407 YLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRItGGEPYLYLQPLIFYPGYYS 467
Cdd:cd10322 383 SLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTL-VWLLLPLASPLGIDPIIPA 442
SLC5sbd_PutP cd11475
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ...
8-444 1.23e-36

Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271369  Cd Length: 464  Bit Score: 142.26  E-value: 1.23e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgCGLAWAQA 87
Cdd:cd11475   1 LITFIVYLLLMLGIGIYSYRKTKTL-------EDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYA--SGLSAIWI 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  88 PIGYSLSLILGGLFFAKPMRS----KGYVTMLDPFQQIYGKRMGGLLFIPALM---GEMFWAAAIFSALGATISVIIDVD 160
Cdd:cd11475  72 AIGLILGAYLNWLFVAKRLRRytekNDSITLPDYLENRFRDKSKLLRILSALIiliFFTIYAAAQLVAGGKLFESLFGID 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 161 VNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSH---PAVTDIGFTAVHAKYQSPWLGTIESVEV 237
Cdd:cd11475 152 YSTGLLIGAVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAAlggLSGLVAALAAIDPGLLSPFGGDLGAGGL 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 238 YTwldnFLLLMLGGIpwqAYF------QRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGAstdwnqtAYgYPDPK 311
Cdd:cd11475 232 LA----IISLLAWGL---GYFgqphilVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGR-------AL-FPDGL 296
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 312 TkEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGAS 391
Cdd:cd11475 297 L-GDPETVFPVLAQELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAFLRKEASDKELVWVSRLAVLVIALI 375
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 31543741 392 ATAMAL-LTKTVYGL----W-YLSSDLVyiiifPQLLCVLFIKGTNTYGAVAGYIFGLF 444
Cdd:cd11475 376 ALLIALnPPSSVFSLvsfaWaGLGAAFG-----PLLLLSLYWKRTTRQGALAGMIAGAV 429
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
1-445 5.56e-35

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 137.20  E-value: 5.56e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   1 MSFHVEGLVAIILFYLLIFLVGIWAAWKTKnsgnpEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgC 80
Cdd:COG4146   1 MGLSTLDYIVFLLYFLLVAGIGYWVSRKKK-----EKTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYA--T 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  81 GLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMF-WAAAIFSALGATISVIIDV 159
Cdd:COG4146  74 GLAVAAYEWMAAIALIILALFFLPFYLKSGIYTMPEFLEKRYDRRTRTILSILFLVSYVFvNLPSVLYAGALALNTIFGV 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 160 DVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALShpAVTDIGF-------TAVHAKYQSPWLGti 232
Cdd:COG4146 154 PLWISVIGLGIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLD--AVGDGSVlagwsalLKVPPEKFNMIGP-- 229
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 233 ESVEVYTWLDNFLLLMLGGIP-W---QAYFQRVLSSSSATYAQVLSFLAAF----GCLVMALPAICIGAIgastdwnqta 304
Cdd:COG4146 230 ADDPDLPWLGIFTGMPILNLFyWgtnQYIVQRALGAKNLKEAQKGVLFAGFlkllIPFIVVLPGIIAFVL---------- 299
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 305 ygYPDPKTKeeADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRIT 384
Cdd:COG4146 300 --FPDGLDN--PDQAYPTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYFNPNASEKQLVKVGRIA 375
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31543741 385 VLVFGASATAMALLTKTVYGLW-YLSSdlVYIIIFPQLLCV----LFIKGTNTYGAVAGYIFGLFL 445
Cdd:COG4146 376 TVVLAVIAILIAPLIGNADGLFqYIQE--VTGFFSPPILAVfllgLFWKRVTAKAAKVALIAGIVL 439
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
45-442 6.97e-31

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 124.72  E-value: 6.97e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741    45 GGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGcgLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGK 124
Cdd:TIGR00813   1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYG--FAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   125 R----MGGLLFIPALMGEMfwAAAIFSAlGATISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLW 200
Cdd:TIGR00813  79 RilrgLSVLSLILYIFLYM--SVDLFSG-ALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   201 ISVPFALShpavtDIGFT-AVHAKYQSPWLGTIESVEVY-------TWLDNFLLLMLGGIPW-------QAYFQRVLSSS 265
Cdd:TIGR00813 156 ILPVFAFS-----EVGGLgTFVEKASQAAPTNPSPDDLYdffrdpsTSDLPWGAGVFGLPHValwywtnQVIVQRCLAAK 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   266 SATYAQVLSFLAAFGCLVMALPAICIGAIGAS--TDWNQTaygyPDPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAA 343
Cdd:TIGR00813 231 SAKHAKKGCLISGVLKLLPMFGAVLPGLIARAlyTDIDPA----LAGAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAA 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   344 VMSSADSSILSASSMFARNIYQLSFRQNAS-DKEIVWVMRITVLVFGASA-TAMALLTKTVYGLWYLSSDLVYIIIFPQL 421
Cdd:TIGR00813 307 VMSTLSSQLNSASTVFTMDLYKKIIRPNASgEKKIVMRGRIAVLVAAVIAgFVAAAQGGQVLQYVQEAFGGLGAPFLPVF 386
                         410       420
                  ....*....|....*....|.
gi 31543741   422 LCVLFIKGTNTYGAVAGYIFG 442
Cdd:TIGR00813 387 LLGIFWKRMNAKGALAGMIAG 407
SLC5sbd_u3 cd11479
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
11-442 2.72e-29

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271373  Cd Length: 454  Bit Score: 120.79  E-value: 2.72e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  11 IILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAQAPIG 90
Cdd:cd11479   6 IALYFAAMIAIGWWGMRRAKTS-------EDYLVAGRRLGPGLYLGTMAAVVLGGASTIGGVGLGYQYGISGMWLVVAIG 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  91 ysLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIVSAL 170
Cdd:cd11479  79 --LGILALSLLLAKRIARLKVYTVSEVLELRYGPSARVISALVMLAYTLMVAVTSTIAIGTVFSVLFGLPRTLSILVGGG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 171 IAILYTLVGGLYSVAYTDVVQLFCIFIGLW-ISVPFALSHPAvtdiGFTAVHAKYQSPWLGtIESVEVYTWLDNFLLLML 249
Cdd:cd11479 157 IVVLYSVLGGMWSITLTDIIQFVIKTIGIFlLLLPLALSKAG----GLSGLQEKLPASYFD-LTSIGWDTIVTYFLLYFF 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 250 GGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTdwnqtaygYPDPKTKEEAdmiLPIVLQYLCP 329
Cdd:cd11479 232 GILIGQDIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVL--------LPDLANPQNA---FATMAQEVLP 300
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 330 VYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLWYLS 409
Cdd:cd11479 301 VGLRGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESERSEVRLSRLFTLLLGVVVIVIAVLVNDVVAALTIA 380
                       410       420       430
                ....*....|....*....|....*....|...
gi 31543741 410 SDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFG 442
Cdd:cd11479 381 YAILVGGLLVPILGGLFWKRATGAGALASMVAG 413
SLC5sbd_u1 cd11477
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
8-463 2.76e-26

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271371  Cd Length: 493  Bit Score: 112.29  E-value: 2.76e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeerSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAQA 87
Cdd:cd11477   3 WLVIALYFLLMLGIGLWFSKRASKS------TSDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  88 PIGysLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLL-----FIPALMGEMFWAAAIFSALGATISVIIDVDVN 162
Cdd:cd11477  77 LWA--VAGLIGAFVFARRWRRLRVLTDGEFPEERYGGRYGAPLrqfyaVYFALLSNVDILAWVFLAAIKVSAVFGPWDPW 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 163 ISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAvtdiGFTAVHAKYQSPWLGTIESVEVYTWLD 242
Cdd:cd11477 155 LTILILGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVG----GPGGLFAQLPEGHLDLFGSGLGASGFY 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 243 NFLLLML---------GGIPWqAYFQRVLSSSSATYA-QVLSFLAA---FGCLVMALPAICIGAIgastdwnqtaygYPD 309
Cdd:cd11477 231 ITFFFILffgwyplsySGGGW-YLAQRYLSAKSEKAAkAAAWLFAAlylVRPWPWMLPALAALVL------------YPD 297
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 310 PKTKEEA-DMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVF 388
Cdd:cd11477 298 LDDPEADfELAYPMMIKEYLPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRFIKPNASEKHLLKVGRLATVLF 377
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31543741 389 GASATAMALLTKTVYGLWYLSSDLVYIIIFPQLLCV---LFIKGTNTYGAVAGYIFGLFLRITGGEPYLYLQPLIFYP 463
Cdd:cd11477 378 GLLSIVVALASDSIGGAFWIVLALGAGLGGPLILPWlwwRFNAWTEIWAMIASIIVGLVVSVLLKVFGLPEDFLFSFL 455
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
43-442 3.68e-26

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 110.89  E-value: 3.68e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741    43 IVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgCGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIY 122
Cdd:pfam00474   2 FLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAA--SGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   123 GKR--------MGGLLFIPALMGEMFWAAAIFsalgatISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFC 194
Cdd:pfam00474  80 GGKrilvylsaLSLLLYFFTYMSVQIVGGARL------IELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   195 IFIGLWISVPFALSHPAvtdiGFTAVHAKYQS--PWLGTIESVEVYTWLDNFL-------LLMLGGIPWQAYFQRVLSSS 265
Cdd:pfam00474 154 MLFGTIILMIIVFHEVG----GYSSAVEKYMTadPNGVDLYTPDGLHILRDPLtglslwpGLVLGTTGLPHILQRCLAAK 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   266 SATYAqVLSFLAAFGCLVMALPaiciGAIGASTDWNQTAYGYPDPKTKE--EADMILPIVLQYLCPVYISFFGLGAVSAA 343
Cdd:pfam00474 230 DAKCI-RCGVLILTPMFIIVMP----GMISRGLFAIALAGANPRACGTVvgCSNIAYPTLAVKLGPPGLAGIMLAVMLAA 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   344 VMSSADSSILSASSMFARNIYQLSFRQN-ASDKEIVWVMRITVLVFGASATAMALLTKTVYGLWYLSSDLVYI--IIFPQ 420
Cdd:pfam00474 305 IMSTLTSQLLSSSSAFTHDLYKNIRRKAsATEKELVGRSRIIVLVVISLAILLAVQPAQMGIAFLVQLAFAGLgsAFLPV 384
                         410       420
                  ....*....|....*....|..
gi 31543741   421 LLCVLFIKGTNTYGAVAGYIFG 442
Cdd:pfam00474 385 ILLAIFWKRVNEQGALWGMIIG 406
SLC5sbd_SGLT1-like cd10329
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ...
8-497 3.76e-26

Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271363  Cd Length: 538  Bit Score: 112.28  E-value: 3.76e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeerSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGcgLAWAQA 87
Cdd:cd10329   1 IVIIAVYFVAVIAIGLWSSRKKRST------VSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASG--IAVGNY 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMF-WAAAIFSALGATISVIIDVDVNISVI 166
Cdd:cd10329  73 EWNAAFVLLLLGWVFLPFYIRSGVSTMPEFLEKRFGGRSRVYLSVLSLILYVFtKISVDLYAGALVIKQLLGWDLYLSII 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 167 VSALIAILYTLVGGLYSVAYTDVVQLFCIFIGlwisvPFALSHPAVTDIGFtavhakyqsPWLGTIESVEVYTWLDNFLL 246
Cdd:cd10329 153 VLLVITAIYTIAGGLKAVIYTDTLQAVILIIG-----SAILMFLAFNEVGG---------GWSAYMAAIPSGTAFHLFRP 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 247 LMLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLAAFGCL----VMALPaiciGAIGASTDWNQTA 304
Cdd:cd10329 219 PDDPDLPWpglllgypilgiwywctdQVIVQRVLAAKNLKHARRGALFAGYLKLlplfLMVLP----GMIARALFPDLVA 294
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 305 YGYPDPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLsFRQNASDKEIVWVMRIT 384
Cdd:cd10329 295 CVVPCGNGVGCSDIAYPTLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKR-LRPEASEKELVRVGRIA 373
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 385 VLVFGASATAMALLTKTVYG-LW-YLSSDLVYIIifPQLLCV----LFIKGTNTYGAVAGYIFGLFLRITGGEPYLYLQP 458
Cdd:cd10329 374 TLVVVVISILWAPIIQAQGGsLFnYIQSVLSYLA--PPIAAVfllgIFWKRTNEQGAFWGLIAGLVLGLVRLILEFAYGE 451
                       490       500       510
                ....*....|....*....|....*....|....*....
gi 31543741 459 LIFYPGYYSDKNGIYnqrfpFKTLSMVTSFFTNICVSYL 497
Cdd:cd10329 452 PDTRPAIIGGIHFLY-----FAFLLFVVSVIVTVIVSLL 485
SLC5sbd_DUR3 cd11476
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ...
10-495 4.21e-26

Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271370  Cd Length: 493  Bit Score: 111.91  E-value: 4.21e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  10 AIILFYLLIFLVG-IWAAWKTKNSGNPEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGlawaqAP 88
Cdd:cd11476   2 GVVIGLGALFALLmVFITRLLKRYRGKNQSSEEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSATVAYQYGVS-----GP 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  89 IGYSLSLILGGLFFA------KPMRSKGYvTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVN 162
Cdd:cd11476  77 FWYASGATLQILLFAplairiKRLAPNAH-TLLEIVRARYGTAAHLVFLVFALFTNVIVLAMLLLGGSAVVNALTGMPIV 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 163 ISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSH-----PAVTDIGFTAVHAKYQSPWLG----TIE 233
Cdd:cd11476 156 AASFLIPLGVLLYTLFGGLRATFLTDYIHTVIILIILLVFAFAVYTSsdigsPSKVYDLLQEAAPDLPVEGNQgsylTFK 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 234 SVEVYTWLDNFLLLMLG-GIPWQAYFQRVLSSSSATYAQVlSFLAafGCLVMALPAICIGAIGASTdwnqTAYGYPDPKT 312
Cdd:cd11476 236 SKAGLIFGIINIVGNFGtVFLDQGYWQRAIAARPSAAVKG-YFLG--GLAWFAIPFLLATTLGLAA----LALGLNPTFE 308
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 313 KEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASA 392
Cdd:cd11476 309 EVSAGLVLPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYRTYINPNATGKQLLRVSRIAVIGFGLFM 388
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 393 TAMALltktvyGLWYLSSDLVYII----------IFPqLLCVLFIKGTNTYGAVAGYIFGLflrITGgepylylqpLIFY 462
Cdd:cd11476 389 GGLAV------GLNYIGISLGWLLlfmgiligsaVFP-VALGLYWRRQTGTAAVVSPIAGL---VAG---------LAVW 449
                       490       500       510
                ....*....|....*....|....*....|...
gi 31543741 463 PGYYSDKNGIYNQRFPFKTLSMVTSFFTNICVS 495
Cdd:cd11476 450 LVTAKSYYGEVNVDTTGGNYPMLAGNLVALFSP 482
PanF COG4145
Na+/panthothenate symporter [Coenzyme transport and metabolism];
2-443 3.92e-24

Na+/panthothenate symporter [Coenzyme transport and metabolism];


Pssm-ID: 443316  Cd Length: 484  Bit Score: 105.69  E-value: 3.92e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   2 SFHVEGLVAIILFYLLIFLVGIWAAWKTKNSGNPEERSeaiiVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCG 81
Cdd:COG4145   1 MMNLAILIPLLIYLLLVLGIGIYASRKRSKGSFLEEYF----LGSRSMGGFVLAMTLAATYTSASSFIGGPGAAYKYGLG 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  82 ---LAWAQAPIGYsLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKR----MGGLLFIPALMGEMfwaAAIFSALGATIS 154
Cdd:COG4145  77 wvlLAMIQVPTAF-LTLGVLGKKFAILGRKYNAVTLADWLRARYQSKalvlLAALLLLLFFIAFM---VAQFVGGARLLE 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 155 VIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIG---LWISVPFALSHPAVTDIGFTAVHAKYQSPwLGT 231
Cdd:COG4145 153 TVTGISYTTGLLIFGVTVVLYTTIGGFRAVVLTDAIQGIIMLVGtvlLLIGVISAGGGIENIMSTLAAIDPNLVSP-TGP 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 232 IESVEVYTWLDNFLLLMLGGIPWQAYFQRVLS---SSSATYAQVLsflaafGCLVMALPAICIGAIGastdwnqtAYGYP 308
Cdd:COG4145 232 DGFLPRPFVISFWILVGFGVIGLPHTAVRCMAykdSKSLHRAMII------GTIVVGLLMFGMHLIG--------VLGRA 297
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 309 DPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNAS--DKEIVWVMRITVL 386
Cdd:COG4145 298 VLPDLTVPDQVIPTLMVKVLPPFLAGIFLAGPLAAIMSTVDSLLLQASSTIVKDLYLNYINPKASenEKKLKRLSKLVTL 377
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31543741 387 VFGAsatamalltkTVYGLWYLSSDLVYIII-----------FPQLLCVLFIKGTNTYGAVAGYIFGL 443
Cdd:COG4145 378 VLGL----------IVFLLALNPPDLIIWLNlfafggleaafFWPLVLGLYWKRANATGAIASMLVGV 435
SLC5sbd_NIS-like_u2 cd11494
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
10-463 1.28e-22

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271385 [Multi-domain]  Cd Length: 473  Bit Score: 101.14  E-value: 1.28e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  10 AIILFYLLIFLVgiWAAWKTKNSGNpeerSEAIIVGGRDIGLLVGGFTMTATWVGG-GYINGTAEAVYGpgcGLAWAQAP 88
Cdd:cd11494   4 IVLVGYLLGILV--YGVYKGRGQKN----QEDYFLGGRSMPWWPIGLSIMATQASAiTFLSAPGQAYSD---GMRFVQYY 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  89 IGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIVS 168
Cdd:cd11494  75 FGLPLAMIFLCITFVPVFYKLKVYTAYEYLERRFGLKTRLLTSILFLISRGLATGVTIYAPAIILSTILGWSLWLTILLI 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 169 ALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTdiGFTAVHAKYQSPWLGTIESveVYTWLD--NFLL 246
Cdd:cd11494 155 GGITIIYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKLLPVG--FVDALLVAGKSGRLNALDF--SFDLSDtyTFWS 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 247 LMLGGI-PWQAYF-------QRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAI--------GASTDWNQTAYGYPDP 310
Cdd:cd11494 231 GLIGGFfLYLSYFgtdqsqvQRYLTAKSIKEARKSLLLNGFLKFPMQFFILLIGVLvfvfyqfnPFPVSFNPAEDETKDT 310
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 311 KtkeeaDMILPIVLQYLCPVYISFFgLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGA 390
Cdd:cd11494 311 N-----YIFLRFVLNYLPPGVIGLL-IAAIFAAAMSSIDSALNSLATVTVIDIYRRFFKKDASDEHYLKVSRLLTVFWGL 384
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31543741 391 SATAMAL---LTKTVYGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRItggepYLYLQPLIFYP 463
Cdd:cd11494 385 LAIVFALfagLAGSLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGVFAGAILGVIVVI-----VLWLFPDVSWL 455
SLC5sbd_PanF cd10327
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ...
8-443 4.48e-18

Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212037  Cd Length: 472  Bit Score: 87.26  E-value: 4.48e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTKNSGNPEerSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCG---LAW 84
Cdd:cd10327   2 LLPIIIYLVILLGIGFYARRSKKRRSGDF--LEEYFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGwvlLAM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  85 AQAPIGYslsLILG--GLFFAKPMRSKGYVTMLDPFQQIYGKRmgGLLFIPALMGEMFWAAAIFSAL--GAT-ISVIIDV 159
Cdd:cd10327  80 IQVPTGF---LTLGvlGKKFAIIARKINAVTIIDYLRARYNSK--ALVVLSSLALIVFFIAAMVAQFigGARlLEAVTGL 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 160 DVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIG---LWISVPFALSHPAVTDIGFTAVHAKYQSPWLGTIESVE 236
Cdd:cd10327 155 SYVTGLLIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGtvlLLVGVLAAGGGMEAIMATLAEIDPNLLTPFGPGFLSPP 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 237 VYtwLDNFLLLMLG--GIPWQAyfQRVLS---SSSATYAQVL-SFLAAFGCLVMALpaicIGAIGASTdwnqtaygYPDP 310
Cdd:cd10327 235 YI--LSFWVLVGFGviGLPQTA--VRCMGykdSKSMHRAMIIgTVVVGFLMLGMHL----AGVLGRAV--------LPDL 298
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 311 ktkEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFR--QNASDKEIVWVMRITVLVF 388
Cdd:cd10327 299 ---EVPDKVIPTLALKVLPPWLAGLFLAGPLAAIMSTVDSQLILASSAIVKDLYLNYKNkeKKTSEKKVKRISLIITIIL 375
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31543741 389 GASATAMALLTKTVyglwylssdLVYIIIFP----------QLLCVLFIKGTNTYGAVAGYIFGL 443
Cdd:cd10327 376 GLLVFLLAINPPDL---------IVWLNLFAfggleaaffwPLVLGLYWKRANATGALASMVVGL 431
SLC5sbd_u2 cd11478
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
137-427 6.19e-18

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271372  Cd Length: 496  Bit Score: 86.96  E-value: 6.19e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 137 GEMFWAAAIFsalgatISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLwisvpFALSHPAVTDI- 215
Cdd:cd11478 130 GINLYALALV------LNVLLGWPLWLSIILSAAIVLAYTTLGGLTSAIYNEVLQFFLIVAGL-----IPLVIIGLIKVg 198
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 216 GFTAVHAKYQSPWLGTIESVEVYTWLDNF---------LLLMLGGIPWQAYF-------QRVLSSSSATYAQVLSFLAAF 279
Cdd:cd11478 199 GWDGLSEKIDANGPPGWNGLSWGPQGSQStnpmgvnlgLVFGLGFVLSFGYWttnflevQRAMAAKDLSAARRTPLIAAF 278
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 280 gcLVMALPAICI--GAIGASTDWNQTAYGYPDPktkeeaDMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASS 357
Cdd:cd11478 279 --PKMFIPFLVIlpGLIALVLVPELGASGGLDY------NQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNT 350
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 358 MFARNIYQLSFRQNASDKEIVWVMRITVLVfgasATAMALLTKtvyglwYLSSDLVYIIIFPQLLCVLFI 427
Cdd:cd11478 351 VFTYDIYQTYIVKDAPDKHYLKVGRIATVV----GVLISIGTA------YIASSFNNIMDYLQLLFSFFN 410
SLC5sbd_vSGLT cd10325
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ...
12-440 2.96e-17

Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271360  Cd Length: 523  Bit Score: 85.05  E-value: 2.96e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  12 ILFYLLIFLVGIWaawKTKNSGNPEERSEAIIVGGRDIGLLVGGFTMTATwvgggyiNGTAEAVYG-PGCGLAWAQAPIG 90
Cdd:cd10325   4 IVYVILIIGLGLW---VSREKKGGEKDATDYFLAGKSLPWWAIGASLIAA-------NISAEQFIGmSGSGFAIGLAIAS 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  91 Y----SLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGA-TISVIIDVDVNISV 165
Cdd:cd10325  74 YewmaAITLIIVAKFFLPIFLKNGIYTMPQFLEERYDGRVRTIMAVFWLLLYVFVNLTSVLYLGAlAIETITGIPLTYSI 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 166 IVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIGFTAVHAKYQSPW------LGTIESVEVYT 239
Cdd:cd10325 154 IGLALFAAAYSIYGGLKAVAWTDVIQVVFLVLGGLVTTYIALSLLGGGEGVFAGFTLLAAEAPehfhmiLDKSNPEDAYK 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 240 WLDNfLLLMLGGIpWQAYF----------QRVLSSSSATYAQVLSFLAAFGCLVM----ALPAICIGAIGASTDWNQTAy 305
Cdd:cd10325 234 DLPG-IAVLLGGL-WVANLsywgfnqyiiQRALAAKSLSEAQKGIVFAAFLKLLIpfivVIPGIAAYVLASNLLLPAAT- 310
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 306 gypdpkTKEEADMILPIVLQYLcPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITV 385
Cdd:cd10325 311 ------GIEKPDQAYPWLLRNL-PTGLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIPKKASEKQLVNVGRLAA 383
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31543741 386 LVFGASATAMALLtktvygLWYLSSDLVYI-----IIFPQLLCV----LFIKGTNTYGAVAGYI 440
Cdd:cd10325 384 VIALIIAALIAPP------LLGLDQAFQYIqeytgFISPGILAIfllgLFWKRATSAGALVAAI 441
SLC5sbd_u4 cd11480
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
8-497 1.29e-16

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271374  Cd Length: 488  Bit Score: 82.55  E-value: 1.29e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAqa 87
Cdd:cd11480   1 IGLFFVFVTITLYITIWAARRTRST-------SDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLAY-- 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDpF--QQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISV 165
Cdd:cd11480  72 AIGWTGGYVLLLLLVAEPLRNFGKYTVPD-FlgARLGSRPVRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGIPYEVGV 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 166 IVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSH----PAVTDIGFTAVHAKYQSPWLGTIESVEVYTW- 240
Cdd:cd11480 151 VVVGALMIVYVVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARfggnPLGAGPGLLGLAAAAASGAGEAYLAPGLLLTd 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 241 -LDNFLL---LMLG--GIPwqAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTDWNQTAYGYPDPKTKE 314
Cdd:cd11480 231 pLDVISLtlaLMLGtaGLP--HVLMRFYTVPDARAARKSVVWALGFIGLFYLLAPALGFGARALVGPDVIGAPIAGELDG 308
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 315 EADMILPIVLQYLCPVYIsFFGL---GAVsAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGAS 391
Cdd:cd11480 309 GGDMAVLLLPEIAGLGDL-LLALvaaGAF-AAILATVAGLLLAAASALAHDLYAGVIRPGASERREVRVARIAAVVVGVI 386
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 392 ATAMALLTKTvyglwylsSDLVYII----------IFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITggepYLYLQPLIF 461
Cdd:cd11480 387 AILLALLFPP--------QNVAFLValafaiaasaFFPVLVLGIFWRRFTTRGAIAGMLVGLLVSLV----LIVLSPAVS 454
                       490       500       510
                ....*....|....*....|....*....|....*....
gi 31543741 462 YPGYYSDKNGiynqrFPFK---TLSMVTSFFTNICVSYL 497
Cdd:cd11480 455 GAPPGHDFAG-----FPLTnpgLVSVPLGFLVAIVVSLL 488
SLC5sbd_SGLT6 cd11490
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ...
8-531 9.42e-16

Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271381  Cd Length: 602  Bit Score: 80.34  E-value: 9.42e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeeRSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAeavygpGCGLAWAQA 87
Cdd:cd11490   2 IVVLVLYFLFVLAVGLWSMWKTKRS-----TVKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLA------GSGAAAGIG 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  88 PIGYSLS-----LILGGLFFakPMRSKGYVTMLDPFQQiygKRMGGLLfIPALMGEMFWAAAIFSAL------GAT-ISV 155
Cdd:cd11490  71 VVAYEWNglfmvLVLAWLFL--PIYIASRVTTMPEYLK---KRFGGKR-IQIFLAVLYLFIYIFTKIsvdmyaGAVfIQQ 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 156 IIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAvtdiGFTAVHAKYQSPwLGTIESV 235
Cdd:cd11490 145 ALQWDLYLAVVGLLGITALYTVAGGLAAVIYTDALQTIIMVIGALILMGYSFAEVG----GFEALLEKYFQA-IPSIRSP 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 236 EVYTWL---DNFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLAAF----GCLVMALP 287
Cdd:cd11490 220 NSTCGIpreDAFHIFrdpVTSDLPWpgvllgmsipslwywctdQVIVQRSLAAKNLSHAKGGSLLAAYlkvlPLFMMVIP 299
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 288 aiciGAIGASTDWNQTAYGypDPKTKEE--------ADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMF 359
Cdd:cd11490 300 ----GMISRILFPDQVACA--DPEVCKEicgnpsgcSDIAYPKLVMELLPTGLRGLMMAVMLAALMSSLTSIFNSASTIF 373
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 360 ARNIYQlSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYG---LWYLSSDLVYIiifPQLLCVLFIKG-----TN 431
Cdd:cd11490 374 TMDLWR-HIRPRASEWELMIVGRVFVLVLVVVSILWIPLVQASQGgqlFIYIQSISSYL---QPPVAVVFIAGcfwkrTN 449
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 432 TYGAVAGYIFGLFLRITGGE-PYLYLQPLIFYPgyysDKNGIYNQRFPFKTLSMVTSFFTNICVSYLAKYlfesgTLPPK 510
Cdd:cd11490 450 EKGAFWGLMVGLAVGLTRMVlDFIYVTPQCDQP----DTRPDIVKYVHYLYFSMILTILTLVVVVCVSLA-----TEPPS 520
                       570       580       590
                ....*....|....*....|....*....|
gi 31543741 511 LDV---------FDAVVarhSEENMDKTIL 531
Cdd:cd11490 521 KEMisrltwftrFDAVV---ESEELKKAIL 547
ActP COG4147
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
8-499 4.60e-15

Na+(or H+)/acetate symporter ActP [Energy production and conversion];


Pssm-ID: 443318  Cd Length: 526  Bit Score: 77.89  E-value: 4.60e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGC-GLAWAq 86
Cdd:COG4147  15 IGIFLVFVTFTLYITIWAARRTKST-------SDFYVAGRGVTGVQNGLAIAGDYMSAASFLGIAGLIALSGYdGLIYS- 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  87 apIGYSLSLILGGLFFAKPMRSKGYVTMLDpfqqIYGKRMG----------GLLFIPAlmgemFWAAAIFSALGATISVI 156
Cdd:COG4147  87 --IGWLVGYVLLLLLLAEYLRNFGKFTVPD----FLGDRFYsrparlvaaiSTLVVSF-----FYLIAQMVGAGVLISLL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 157 IDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQ----LFCIFIG-LWISVPFALSHPAVTD--IGFTAVHAKYQSPWL 229
Cdd:COG4147 156 LGVDYEVAVVIVGVLMIVYVVLGGMKGTTWVQIIKavllIFAYTVPaVLVLAQFGFNPLPLLAkaAEVHDLGAAYLEPGG 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 230 GtiesveVYTWLDNFLL---LMLG--GIPW---------QAYFQRvlssSSATYAQVLSFLAAFGCLVMALPAICIgaIG 295
Cdd:COG4147 236 L------VKSPLDFISLglaLMLGtaGLPHilmrfftvpDAKEAR----KSVGWALGFIGLFYLTAPALGFGARAL--VG 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 296 ASTDWNQTAYGYPDPKTKEEADMILPIVLQyLCPVYISFFGLGAVsAAVMSSADSSILSASSMFARNIYQLSFRQNASDK 375
Cdd:COG4147 304 PLPEWFDTGLIGAADGGGNMAVLALAEIAG-GGNWLLGLVAAGAF-ATILAVVAGLLLAIASAISHDLYANVIKGKATEK 381
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 376 EIVWVMRITVLVFGASATAMALLTKT--VYGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITggepY 453
Cdd:COG4147 382 EELRVARIAAVVIGVVAILLGINAPPqnVAFLVALAFALAASANFPVLLLSIFWKRFNTRGAVAGMLVGLISALV----L 457
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*....
gi 31543741 454 LYLQPLIFYPgyysdknGIYNQRFPFK---TLSMVTSFFTNICVSYLAK 499
Cdd:COG4147 458 IVLSPFVWVL-------GVDAALFPLEnpgLVSMPLGFLVAIVVSLLTP 499
SLC5sbd_NIS-like_u3 cd11495
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
3-443 3.95e-14

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271386 [Multi-domain]  Cd Length: 473  Bit Score: 74.88  E-value: 3.95e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   3 FHVEGLVAIILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGL 82
Cdd:cd11495   1 FGWLDYLVLVIYLLAMLGIGLYFSKKQKST-------DDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNY 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  83 AWAQapIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRM---GGLLFIPALMGEMfwaAAIFSALGATISVIIDV 159
Cdd:cd11495  74 FVGS--LSIIIAAPLAAYFFVPFFRRLNVTSAYEYLEKRFGPWArvyGSLLFILFQLGRM---GIVLYLPALALSAVTGI 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 160 DVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHpavTDIGFTAV------HAKYqspWLGTie 233
Cdd:cd11495 149 NPYIIIILMGVLCIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFS---IPGGFGEVfdiaiaNGKF---SLGD-- 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 234 svEVYTWLDN-FLLLMLGGIPW--------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGaigastdwnqTA 304
Cdd:cd11495 221 --FSFSLTEStIWVIFIGGIFNnlqsytsdQDVVQRYLTTKSIKEAKKSLWTNALLALPVALLFFGIG----------TA 288
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 305 -YGY-----PDPKTKEEADMILP-IVLQYLcPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQlSFRQNASDKEI 377
Cdd:cd11495 289 lYVFyqqhpELLPAGINGDAVFPyFIVTQL-PVGVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYK-RLSPDPSDKQY 366
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31543741 378 VWVMRITVLVFGASATAMALL-----TKTVYGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGL 443
Cdd:cd11495 367 LKVARLITLLVGLLGTLVALYlanagVKSLLDAFNTLTGLFGGGLAGLFLLGIFTKRANAKGALVGIIVSI 437
SLC5sbd_SGLT2 cd11487
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ...
11-445 6.56e-14

Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212056 [Multi-domain]  Cd Length: 583  Bit Score: 74.57  E-value: 6.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  11 IILFYLLIFLVGIWAAWKTkNSGNpeerSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAvyGPGCGLAWAQAPIG 90
Cdd:cd11487   6 IAAYFLLVIGVGLWSMCRT-NRGT----VGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGT--GAASGIAVAGFEWN 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  91 YSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYG-KRMGGLLFIPALMGEMFWAAAIFSALGAT-ISVIIDVDVNISVIVS 168
Cdd:cd11487  79 ALFVVLLLGWLFVPVYLTAGVITMPQYLKKRFGgQRIRLYLSVLSLFLYIFTKISVDMFSGAVfIQQALGWNIYASVIAL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 169 ALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAvtdiGFTAVHAKYQS----------PWLGTIESVEVY 238
Cdd:cd11487 159 LGITMIYTVTGGLAALMYTDTVQTFVIIGGACVLMGYAFHEVG----GYSALFEKYLKavpsltvsedPAVGNISSSCYR 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 239 TWLDNFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLAAF------------------ 279
Cdd:cd11487 235 PRPDSYHLLrdpVTGDLPWpalilgltivsswywcsdQVIVQRCLAARSLTHVKAGCILCGYlkllpmflmvmpgmisrv 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 280 ------GCLVmalPAICIGAIGASTDWNQTAYgypdpktkeeadmilPIVLQYLCPVYISFFGLGAVSAAVMSSADSSIL 353
Cdd:cd11487 315 lypdevACVE---PSVCLRVCGTEVGCSNIAY---------------PKLVVKLMPNGLRGLMLAVMLAALMSSLASIFN 376
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 354 SASSMFARNIYQlSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYG---LWYLSSDLVYII--IFPQLLCVLFIK 428
Cdd:cd11487 377 SSSTLFTMDIWT-RLRPQAGDKELLLVGRVWVVCIVAVSVAWIPVVQAAQGgqlFDYIQSVSSYLAppIAAVFFLALFVK 455
                       490
                ....*....|....*..
gi 31543741 429 GTNTYGAVAGYIFGLFL 445
Cdd:cd11487 456 RVNEPGAFWGLIGGLLM 472
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
11-447 8.32e-14

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 74.20  E-value: 8.32e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  11 IILFYLLIFLVGIWAAWKTkNSGNpeerSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAeavygpGCGLAWAQAPIG 90
Cdd:cd11486   6 IVIYFVVVLAVGVWAMVST-NRGT----VGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIA------GTGAAAGIAIGG 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  91 YS-----LSLILGGLFFAKPMRSkGYVTMLDPFQQIYG-KRMGGLLFIPALMGEMFW--AAAIFSalGAT-ISVIIDVDV 161
Cdd:cd11486  75 FEwnalvVVVVLGWLFVPIYIKA-GVVTMPEYLRKRFGgQRIQVYLSVLSLCLYIFTkiSADIFS--GAIfINLALGLNL 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 162 NISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAvtdiGFTAVHAKYQ-------SPWLGTIES 234
Cdd:cd11486 152 YLAIVILLAITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVG----GYDAFMEKYMtaipsviGTGNSTSQE 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 235 VEVYTWLDNFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQV-------LSFLAAFgCLVM-- 284
Cdd:cd11486 228 KCYTPRADSFHIFrdpITGDLPWpgllfglsiltlwywctdQVIVQRCLSAKNMSHVKAgcilcgyLKLLPMF-IMVMpg 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 285 -------------ALPAICIGAIGASTDWNQTAYgypdpktkeeadmilPIVLQYLCPVYISFFGLGAVSAAVMSSADSS 351
Cdd:cd11486 307 misrilytdeiacVVPDECKAVCGTEVGCTNIAY---------------PKLVVELMPNGLRGLMLSVMLASLMSSLTSI 371
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 352 ILSASSMFARNIYQlSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYG---LWYLSSDLVYII--IFPQLLCVLF 426
Cdd:cd11486 372 FNSASTLFTMDIYT-KVRKKASEKELMIAGRLFMLVLIGISIAWVPIVQSAQSgqlFDYIQSITSYLGppIAAVFLLAIF 450
                       490       500
                ....*....|....*....|.
gi 31543741 427 IKGTNTYGAVAGYIFGLFLRI 447
Cdd:cd11486 451 CKRVNEPGAFWGLCVGLLVGL 471
PRK15419 PRK15419
sodium/proline symporter PutP;
1-396 6.40e-13

sodium/proline symporter PutP;


Pssm-ID: 185317  Cd Length: 502  Bit Score: 71.20  E-value: 6.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741    1 MSFHVEGLVAIILFYLLIFLVGIWAAWKTKNSGNpeerseaIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGC 80
Cdd:PRK15419   1 MAISTPMLVTFCVYIFGMILIGFIAWRSTKNFDD-------YILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGI 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   81 GLAWAQapIGYSLSLILGGLFFAKPMR-----SKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISV 155
Cdd:PRK15419  74 SESWIA--IGLTLGAWINWKLVAGRLRvhteyNNNALTLPDYFTGRFEDKSRILRIISALVILLFFTIYCASGIVAGARL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  156 I---IDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISvpfalshPAVTDIGFTAVHAKYQSPWLGTI 232
Cdd:PRK15419 152 FestFGMSYETALWAGAAATILYTFIGGFLAVSWTDTVQASLMIFALILT-------PVIVIISVGGFGDSLEVIKQKSI 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  233 ESVEVYTWLDNFLLLMLGGipWQ----------AYFQRVLSSSSATYAQVLSFLAAFGCLVmalPAICIGAIGASTDWNQ 302
Cdd:PRK15419 225 ENVDMLKGLNFVAIISLMG--WGlgyfgqphilARFMAADSHHSIVHARRISMTWMILCLA---GAVAVGFFGIAYFNEH 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  303 TAYGypdPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMR 382
Cdd:PRK15419 300 PAVA---GAVNQNAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGR 376
                        410
                 ....*....|....
gi 31543741  383 ITVLVFGASATAMA 396
Cdd:PRK15419 377 VMVLVVALVAIALA 390
SLC5sbd_NIS-like_u1 cd11493
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
10-398 7.05e-13

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271384 [Multi-domain]  Cd Length: 479  Bit Score: 71.09  E-value: 7.05e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  10 AIILFYLL-IFLVGIWAAWKTKNSgnpeersEAIIVGGRDI------GLLVGGFTMTATWVGG---GYINGtaeavygpg 79
Cdd:cd11493   3 AVIVLYLLgLPLLGLWLSGRQKST-------ADYFLGGRSMpwwavcLSVVATETSTLTFLSIpglAYGGD--------- 66
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  80 cgLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDV 159
Cdd:cd11493  67 --LTFLQLALGYILGRIIVAFVLLPRYFRGEVVSAYELLGQRFGGGMQKTASVTFLVTRLLADGVRLFAAAIPVSMILGA 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 160 D-----VNISVIVSALIAILYTLVGGLYSVAYTDVVQlFCIFIGLWISVPFALSHPAVTDIGFTAVHA-KYQSPWLG--T 231
Cdd:cd11493 145 DgvalsYIASILIISVVTLLYTYFGGIRAVVWTDVIQ-LVVYIGGAVAALAYLLGALPADWLQIAAAAgKFHLFDLSdlI 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 232 IESVEVYTwldnFLLLMLGGIPW--------QAYFQRVL---SSSSATYAQVLSFLAAFgcLVMALpAICIGAIGAstdw 300
Cdd:cd11493 224 LGLTSPYT----FWAAIIGGALLsmashgtdQLMVQRLLacrNLRDAQKALIGSGVVVF--PQFAL-FLLIGLLLY---- 292
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 301 nqTAYGYPDPKTKE--EADMILP-IVLQYLcPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEI 377
Cdd:cd11493 293 --VYYGGASLAALGlgSPDEVFPyFIVHEL-PAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRRRLSDEKL 369
                       410       420
                ....*....|....*....|.
gi 31543741 378 VWVMRITVLVFGASATAMALL 398
Cdd:cd11493 370 LRASRLLTLVWAVVLVGIALL 390
SLC5sbd_SGLT4 cd11488
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ...
8-448 1.05e-12

Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.


Pssm-ID: 271380  Cd Length: 605  Bit Score: 70.73  E-value: 1.05e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTkNSGNpeerSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAvyGPGCGLAWAQA 87
Cdd:cd11488   2 IAVVVVYFVFVLAVGIWSSIRA-SRGT----VGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGT--GAAGGLAVGGF 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQ--------QIYGKRMGGLLFIPALMGEMFWAAAIFsalgatISVIIDV 159
Cdd:cd11488  75 EWNAAWVLIALGWIFVPVYIAAGVVTMPEYLKkrfggqriRIYMSVLSLILYIFTKISTDIFSGALF------IQVSLGW 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 160 DVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGlwisvPFALSHPAVTDIG-FTAVHAKYQS--PWLGTIESVE 236
Cdd:cd11488 149 NLYLSTVILLAVTALYTIAGGLTAVIYTDALQTVIMVIG-----AFVLMFIAFDKVGwYPGLEQQYEKaiPALTVPNTTC 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 237 VYTWLDNFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLAAF------------GCLV 283
Cdd:cd11488 224 HLPRSDAFHIFrdpVTGDIPWpglifgltvlatwvwctdQVIVQRSLSAKNLSHAKGGSVLGGYlkilpmffvvmpGMIS 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 284 MAL---------PAICIGAIGASTDWNQTAYgypdpktkeeadmilPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILS 354
Cdd:cd11488 304 RALfpdevgcvdPDECQKICGAKVGCSNIAY---------------PKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNS 368
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 355 ASSMFARNIYQlSFRQNASDKEIVWVMRITVLVFGA-SATAMALLTKTVYGLW--YLSSDLVYII--IFPQLLCVLFIKG 429
Cdd:cd11488 369 SSTLFTMDVWQ-RIRRRASEQELMVVGRVFILLLVViSILWIPIIQTANSGQLfdYIQAVTSYLSppITAVFILAIFWKR 447
                       490
                ....*....|....*....
gi 31543741 430 TNTYGAVAGYIFGLFLRIT 448
Cdd:cd11488 448 VNEPGAFWGLMVGLVVGLV 466
SLC5sbd_SGLT5 cd11489
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ...
5-448 1.52e-12

Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212058  Cd Length: 604  Bit Score: 70.35  E-value: 1.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   5 VEGLVAIILFYLLIFLVGIWAAWK-TKNSGNpeerseAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAvyGPGCGLA 83
Cdd:cd11489   2 VADIIVIGVYFALNVAVGIWSSCRvSRNTVS------GYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGT--GAAGGIA 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  84 WAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYG-KRMGGLLFIPALMGEMFWAAAIFSALGAT-ISVIIDVDV 161
Cdd:cd11489  74 VAGFEWNATYALLALAWVFVPVYISSGIVTMPEYLQRRFGgERIRMYLSVLSLLLSVFTKISTDLYSGALfVQVCLGWNL 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 162 NISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWIsvpfaLSHPAVTDIGFtavHAKYQSPWLGTIESVEV---- 237
Cdd:cd11489 154 YLSTVLMLVVTALYTIAGGLAAVIYTDALQTLIMVIGAVI-----LTIKAFNQIGG---YSNLEEAYLQAVPSKIIpntt 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 238 -----YTWLDNFLLLMLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLAAF------GCLVM---- 284
Cdd:cd11489 226 chlprADAMHLFRDPVTGDLPWtgmtfgltimatwywctdQVIVQRSLSARSLSHAKGGSILASYlkmlpmGLIIMpgmi 305
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 285 -----------ALPAICIGAIGASTDWNQTAYgypdPKTKEEadmILPIVLQYLCpvyisffgLGAVSAAVMSSADSSIL 353
Cdd:cd11489 306 sralfpddvacVDPEECLRVCGAEVGCSNIAY----PKLVME---LMPSGLRGLM--------IAVMMAALMSSLTSIFN 370
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 354 SASSMFARNIYQlSFRQNASDKEIVWVMRI-TVLVFGASATAMALLTKTVYGLWYLSSDLVYIIIFPQLLCV----LFIK 428
Cdd:cd11489 371 SSSTLFTMDIWR-RLRPGASERELLLVGRLvTVILVGVSVVWIPILQSSNSGQLYIYIQSVTSYLAPPVTAVfvlaVFWR 449
                       490       500
                ....*....|....*....|
gi 31543741 429 GTNTYGAVAGYIFGLFLRIT 448
Cdd:cd11489 450 RANEQGAFWGLMAGLVVGLT 469
SLC5sbd_NIS-like cd10326
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
10-460 3.17e-12

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271361 [Multi-domain]  Cd Length: 472  Bit Score: 68.74  E-value: 3.17e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  10 AIILFYLLI-FLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGG-GYINGTAEaVYGPGcgLAWAQA 87
Cdd:cd10326   3 AVVVVYFLIlLAISYYTSRRNADN-------DDFFLGNRQSPWYLVAFSMIGTSLSGvTFVSVPGE-VGGSG--FTYLQM 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRM---GGLLFipaLMGEMFWAAAIFSALGATISVII----DVD 160
Cdd:cd10326  73 VLGFLLGYLIIAFVLLPLYYRLNLTSIYEYLEDRFGVSSrktGAVFF---LLSRILGAGIRLYLVALVLQQFLfdslGIP 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 161 VNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHpavTDIGF-TAVHAKYQSPWLGTIesveVYT 239
Cdd:cd10326 150 FWLTVLITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNS---LGLGFgEAISAAGESGYSRIF----NFD 222
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 240 WLD---NFLLLMLGGIPW--------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGAStdwnqTAYGYP 308
Cdd:cd10326 223 DDNsrrTFWKQFLGGIFItiamtgldQDMMQRNLSCKNLKDAQKNMLTFGVILVPVNLLFLLLGVLLYT-----YAQKNG 297
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 309 DPKTKEEADMILP-IVLQYLCPVYISFFGLGAVSAAvMSSADSSILSASSMFARNIYQLSFRQN--ASDKEIVWVMRITV 385
Cdd:cd10326 298 IALPAKDSDQLFPyFALNGLPPGVSGLFVAGIIAAA-MSSADSALTALTTSFCVDILNRFKRKSekKSERKYVHIAFSLT 376
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 386 LVFGASATAMALLTKTVYGLWYLSSDLVYIIIFPQLLCVLFIKGTNT--YGAVAG-------YIFGLFLRITGGEPYLYL 456
Cdd:cd10326 377 FVLGILVFGSASNSGSLIDAIFKVAGYTYGPLLGLFAFGLFTKRAVKdkWVPLVGllapvlsYLLVSNSEGFFGYKFGFE 456

                ....
gi 31543741 457 QPLI 460
Cdd:cd10326 457 LLII 460
PRK10484 PRK10484
putative transporter; Provisional
8-449 7.41e-12

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 67.99  E-value: 7.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741    8 LVAIILFYLLIFLVGIWAAWKTKNSGnpEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCG-LAW-A 85
Cdd:PRK10484   1 MLTILSFLGFTLLVAVISWWKTRKTD--TSSSDGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSvMAWeV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   86 QAPIgyslSLILGGLFFAKPMRSKGYVTMLDPFQQIYG---KRMGGLLFIPALMGEMFWAAAIFSALGAT----ISVIID 158
Cdd:PRK10484  79 TAAI----ALIILALIFLPRYLKSGITTIPDFLEERYDkttRRIVSILFLIGYVVSFLPIVLYSGALALNslfhVSELLG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  159 VD----VNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFAL-----------------SHPAvtdiGF 217
Cdd:PRK10484 155 ISygaaIWLLVWLIGIIGAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLialgdgsfmqgleqlttVHPE----KL 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  218 TAVHAKYQS-PWlGTIES----VEVYTWLDNflllmlggipwQAYFQRVLSSSSATYAQ----VLSFLAAFGCLVMALPa 288
Cdd:PRK10484 231 NSIGGATDPvPF-PTLFTglilVNLFYWCTN-----------QSIVQRALGAKNLAEGQkgalLAAFFKLLGPLILVLP- 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  289 iciGAIGAstdwnqtaYGYPDPKTKeeADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSF 368
Cdd:PRK10484 298 ---GIIAF--------HLYGDGLPN--ADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPII 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  369 RQNASDKEIVWVMRITVLVFGASATAMA-LLTKTVYGLWYLSSDLVYIIIFPQLLCVL---FIKGTNTYGAVAGYIFGLF 444
Cdd:PRK10484 365 NPNASEKQLVKVGKKFGFVLAIISMIVApLIANAPQGLYSYLQQLNGIYNVPILAIIIvgfFTKRVPALAAKVALGFGII 444

                 ....*
gi 31543741  445 LRITG 449
Cdd:PRK10484 445 LYIII 449
SLC5sbd_YidK cd10328
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ...
14-445 2.17e-11

uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271362  Cd Length: 472  Bit Score: 66.41  E-value: 2.17e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  14 FYLLIFLVGIWAAWKTKNSGNpeERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPG-CGLAW-AQAPIGy 91
Cdd:cd10328   1 FLLFTALVALISWYKTRGDDL--SSSDGYFLAGRSLTGVVIAGSLLLTNLSTEQLVGLNGQAYALGmSVMAWeVTAAIA- 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  92 slsLILGGLFFAKPMRSKGYVTMLDPFQQIYG---KRMGGLLFIPALMGEMFWAAAIFSALGatISVIIDVD-------- 160
Cdd:cd10328  78 ---LIILALVFLPRYLKGGITTIPEFLEERYDettRRIVSILFLLGYVVILLPIVLYSGALA--LNSLFDVSellgisyf 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 161 --VNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGlWISVPF----ALSHPAVT---DIGFTAVHAKYQS----- 226
Cdd:cd10328 153 qaLWLLVWLIGIIGAIYAIFGGLKAVAVSDTINGVGLLIG-GLLIPIlgliALGDGSFLaglDTLLTAHPEKLNAiggad 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 227 ---PWlGTIES----VEVYTWLDNflllmlggipwQAYFQRVLSSSSATYAQ----VLSFLAAFGCLVMALPAICigaig 295
Cdd:cd10328 232 spvPF-STLFTgmllVNLFYWCTN-----------QAIIQRALAAKNLKEGQkgvlLAGFFKLLVPLILVLPGII----- 294
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 296 astdwnqTAYGYPDpkTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDK 375
Cdd:cd10328 295 -------AFHLYGD--GLENADMAYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIINKNATDK 365
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31543741 376 EIVWVMRITVLVFGASATAMA-LLTKTVYGLWYL---SSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFL 445
Cdd:cd10328 366 QLVKVGKIFGIVLALISMIIApFIAYAPEGLFNYlqqFNGFFSIPILAIVLVGFFTKRVPALAAKIALIFGVIL 439
SLC5sbd_SMIT cd11491
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ...
8-445 2.12e-09

Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271382  Cd Length: 609  Bit Score: 60.27  E-value: 2.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeeRSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAvyGPGCGLAWAQA 87
Cdd:cd11491   2 IAVVALYFILVMCIGIYAMWKSNRS-----TVSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAGS--GAAAGFAVGAF 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYG-KRMGGLLFIPALMGEMFWAAAIFSALGAT-ISVIIDVDVNISV 165
Cdd:cd11491  75 EFNALILLQLLGWVFIPVYIRSGVYTLPEYLSKRFGgHRIQVYLAALSLILYIFTKISVNLYSGALfIQEALGWNLYVSI 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 166 IVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISV---------------PFALSHPAVTDIGFTAVHAKYQS---- 226
Cdd:cd11491 155 ILLLGLTALLTVTGGLAAVIYTDTLQAFLMIIGALTLMiismmeiggfegvksRYMLASPNVTSILLTYNLSNTNSccvh 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 227 -----------------PWLGTI---ESVEVYTWLDNflllmlggipwQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAL 286
Cdd:cd11491 235 pkkdafkllrdptdedvPWPGFIlgqTPASIWYWCAD-----------QVIVQRVLAAKSLSHAQGATLMAGFIKLLPLF 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 287 PAICIGAIGASTDWNQTAYGYPDP------KTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFA 360
Cdd:cd11491 304 IIVIPGMISRILFPDDIACINPEHcmqvcgSRAGCSNIAYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFT 383
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 361 RNIYQLsFRQNASDKEIVWVMRITVLVF-GASATAMALLTKTVYGLWYLSSDLVYIIIFPQL----LCVLFIKGTNTYGA 435
Cdd:cd11491 384 LDVYKL-IRKKASSRELMIVGRIFVAVMvVISIAWIPVIQEMQGGQLYLYIQEVAAYLTPPVaslyLLAIFWKRTTEQGA 462
                       490
                ....*....|
gi 31543741 436 VAGYIFGLFL 445
Cdd:cd11491 463 FYGGMAGFVL 472
SLC5sbd_NIS-SMVT cd11492
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
152-464 1.38e-06

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271383 [Multi-domain]  Cd Length: 522  Bit Score: 50.95  E-value: 1.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 152 TISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPavtdIGFTAVhakyqspWLGT 231
Cdd:cd11492 141 ALSQVTGINLHIIILVVGIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDV----GGFSEV-------WEIA 209
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 232 IES--VEVYTW-LD-----NFLLLMLGG-IPW-------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIG 295
Cdd:cd11492 210 EEGgrLEFFNFdPDptvrhTFWSLVIGGtFTWlslygvnQTQVQRYLSLPSLKSAKKALWLNIVGLILILSLCCFTGLVI 289
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 296 ASTdwnqtaYGYPDPKTK---EEADMILPIVLQYLCPVYISFFGL---GAVSAAvMSSADSSILSASSMFARNIYQLSFR 369
Cdd:cd11492 290 YAK------YHDCDPLTAgliKKPDQLLPYFVMDVLGHLPGLPGLfvaGIFSAA-LSTLSSGLNSLAAVILEDFIKPFFK 362
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 370 QNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLWYLSSDLVYIIIFPqLLCV----LFIKGTNTYGAVAGYIFGLF- 444
Cdd:cd11492 363 KKLSERQATNIMKLLVVVFGLLCIGLAFLVEKLGGVLQLSLSIFGITGGP-LLGIftlgMFFPWANSKGALVGLLVGLIf 441
                       330       340
                ....*....|....*....|.
gi 31543741 445 -LRITGGEPYLYLQPLIFYPG 464
Cdd:cd11492 442 mLWIGIGGQIAIAPGPLSFPP 462
SLC5sbd_SMVT cd11504
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ...
100-445 4.88e-05

Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271394 [Multi-domain]  Cd Length: 527  Bit Score: 46.02  E-value: 4.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 100 LFFAKPMRSKGYVTMLdpFQQIYgkRMGGLLFIPALmgemfwaaaifsalgaTISVIIDVDVNISVIVSALIAILYTLVG 179
Cdd:cd11504 112 LRFNKTVRICGTVTFI--FQMVI--YMGVVLYAPAL----------------ALNAVTGFNLWISVLAMGVVCTFYTALG 171
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 180 GLYSVAYTDVVQLFCIFIG-LWISVPFALSHPAVTDIGFTAVHAKYQSPWLGTIESVEVYT-WL----DNFLLLMLGGIP 253
Cdd:cd11504 172 GLKAVIWTDVFQTVVMFAGqLAVIIVGSIEAGGIARVWRVAAESDRIDGFNLSPDPTIRHTfWTlvvgGVFNMLALYGVN 251
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 254 wQAYFQRVLSSSSATYAqVLSFLAAFGCLVMALPAIC-IGAIGASTdwnqtaYGYPDPKTKEEADMILPIVLQYLCPVYI 332
Cdd:cd11504 252 -QAQVQRYLSSRTEKQA-KRSCYLVFPGQQLSLCIGClCGLVMFAR------YHECDPLKNGIVARSDQLVPYFVMDVLD 323
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 333 SFFGL-GAVSAAVMSSADSSILSASSMFA----RNIYQLSFRqNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLWY 407
Cdd:cd11504 324 GLPGLpGLFIACLFSGALSTISSAFNSLAtvtmEDLIVPKFP-DMTEERATLLSKGLAVGYGLLCLLMAYLASTMGQVLQ 402
                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 31543741 408 LSSDLVYIIIFP--QLLCV-LFIKGTNTYGAVAGYIFGLFL 445
Cdd:cd11504 403 AANSIFGMIGGPllGLFCLgMFFPCANSAGAVVGLLAGLFM 443
SLC5sbd_NIS cd11503
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ...
21-201 1.97e-03

Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271393  Cd Length: 535  Bit Score: 40.98  E-value: 1.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  21 VGIWAAWKTKNsgnpEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgCGLAWAQAPIGYSLSLILGGL 100
Cdd:cd11503  16 IGLFVGLARGG----QRSADDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYR--YGLKFLWMCLGQLLNSLMTAV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 101 FFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIVSALIAILYTLVGG 180
Cdd:cd11503  90 LFMPVFYRLGITSTYQYLEMRFSRAVRLCGTLQFIVATMLYTGIVIYAPALILNQVTGLDIWASLFSTGIICTFYTTVGG 169
                       170       180
                ....*....|....*....|.
gi 31543741 181 LYSVAYTDVVQLFCIFIGLWI 201
Cdd:cd11503 170 MKAVIWTDVFQVVVMLSGFWA 190
SLC5sbd_SMCT cd11505
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; ...
2-405 7.76e-03

Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. It also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and, through transporting L-lactate and ketone bodies, helps maintain the energy status and the function of neurons. SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. hSMCT2 is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, SMCT2 may initiate lactate absorption in the early parts of the tubule, SMCT1 in the latter parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271395  Cd Length: 538  Bit Score: 39.10  E-value: 7.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741   2 SFHVEGLVAIILFYLLIFLVGIWAAWKtknsGNPEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgCG 81
Cdd:cd11505   3 NFAVWDYVVFAAMLFISAGIGIYYAFA----GGGQATSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPSEVYR--FG 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741  82 LAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDV 161
Cdd:cd11505  77 ASFLIFAFAYLFVVLISSEVFLPVFYRLGITSTYEYLELRFNKPVRLAGTVLFIVQTILYTGIVIYAPALALNQVTGFDL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 162 NISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHP-AVTDIGFTAVHAKYQSPWLGTIESVEVYTw 240
Cdd:cd11505 157 WGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFLSVIIQAVVHQgGIHNILNDSYNGSRLNFWDFDPNPLRRHT- 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 241 ldnFLLLMLGG-IPW-------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTdwnqtaYGYPDPKT 312
Cdd:cd11505 236 ---FWTITVGGtFTWtgiygvnQSQVQRYISCKTRFQAKLSLYFNLLGLWAILVCAVFSGLAMYSH------YKDCDPWT 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543741 313 KE---EADMILPIVLQYLCPVYISFFGLGAVSA--AVMSSADSSILSASSMFARNIYQLSFRqNASDKEIVWVMRITVLV 387
Cdd:cd11505 307 AKivsAPDQLMPYLVLDILADYPGLPGLFVACAysGTLSTVSSSINALAAVTVEDLIKPYFR-SLSEKLSSWISKGLSLL 385
                       410
                ....*....|....*...
gi 31543741 388 FGASATAMALLTKTVYGL 405
Cdd:cd11505 386 YGAMCIGMAVAASLMGGL 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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