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Conserved domains on  [gi|149274653|ref|NP_065831|]
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protein dispatched homolog 3 [Homo sapiens]

Protein Classification

RND transporter family protein( domain architecture ID 1001856)

resistance-nodulation-cell division (RND) transporter family protein

Gene Ontology:  GO:0016020|GO:0055085
PubMed:  10941792
TCDB:  2.A.6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MMPL super family cl34072
Predicted exporter protein, RND superfamily [General function prediction only];
431-616 4.81e-27

Predicted exporter protein, RND superfamily [General function prediction only];


The actual alignment was detected with superfamily member COG1033:

Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 119.19  E-value: 4.81e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  431 AMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVAL-FLYhvV 509
Cdd:COG1033   188 AIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--L 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  510 FGIQyLGILNGVAAFVIVGIGVDDVFVFINTYRQAT-HLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVH 588
Cdd:COG1033   266 LGIP-LSPLTILVPPLLLAIGIDYGIHLLNRYREERrKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIR 344

                         170       180
                  ....*....|....*....|....*...
gi 149274653  589 DFGLFMSLIVSCCWLAVLVTMPAALGLW 616
Cdd:COG1033   345 DFGIVAAIGVLLAFLTSLTLLPALLSLL 372
MMPL super family cl34072
Predicted exporter protein, RND superfamily [General function prediction only];
1187-1344 5.04e-13

Predicted exporter protein, RND superfamily [General function prediction only];


The actual alignment was detected with superfamily member COG1033:

Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 73.74  E-value: 5.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653 1187 LVLSLLICVAAVAVFTTHILLLLPvllsilGIVCLVVTI------MYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYL 1260
Cdd:COG1033   224 FPLALLLILLLLFLFFRSLRGVLL------PLLVVLLAViwtlglMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYR 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653 1261 -LAGENLPPHQAedARtqrqwrtlEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTA 1339
Cdd:COG1033   298 eERRKGLDKREA--LR--------EALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPA 367


                  ....*
gi 149274653 1340 LLGIM 1344
Cdd:COG1033   368 LLSLL 372
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
431-616 4.81e-27

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 119.19  E-value: 4.81e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  431 AMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVAL-FLYhvV 509
Cdd:COG1033   188 AIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--L 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  510 FGIQyLGILNGVAAFVIVGIGVDDVFVFINTYRQAT-HLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVH 588
Cdd:COG1033   266 LGIP-LSPLTILVPPLLLAIGIDYGIHLLNRYREERrKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIR 344

                         170       180
                  ....*....|....*....|....*...
gi 149274653  589 DFGLFMSLIVSCCWLAVLVTMPAALGLW 616
Cdd:COG1033   345 DFGIVAAIGVLLAFLTSLTLLPALLSLL 372
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1187-1344 5.04e-13

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 73.74  E-value: 5.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653 1187 LVLSLLICVAAVAVFTTHILLLLPvllsilGIVCLVVTI------MYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYL 1260
Cdd:COG1033   224 FPLALLLILLLLFLFFRSLRGVLL------PLLVVLLAViwtlglMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYR 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653 1261 -LAGENLPPHQAedARtqrqwrtlEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTA 1339
Cdd:COG1033   298 eERRKGLDKREA--LR--------EALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPA 367


                  ....*
gi 149274653 1340 LLGIM 1344
Cdd:COG1033   368 LLSLL 372
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 485-615 5.14e-13

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 67.99  E-value: 5.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   485 VFLSFFGIASIGLS--CLVALFLYhvvFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAG 562
Cdd:pfam12349    6 FGLGLAGVIIVLASvaSSLGLCAY---FGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGEVG 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 149274653   563 KATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:pfam12349   83 PSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSL 135
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 441-615 1.29e-10

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 66.01  E-value: 1.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   441 VQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALfLYHVVFGIQYLGILNG 520
Cdd:TIGR00921  547 VKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAI-GLMGLRGIPSFLAMAT 625

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   521 VAAfVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSC 600
Cdd:TIGR00921  626 TIS-IILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLS 704

                          170
                   ....*....|....*
gi 149274653   601 CWLAVLVTMPAALGL 615
Cdd:TIGR00921  705 SLTAALVVFPALLVL 719
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 1219-1341 2.10e-07

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 55.61  E-value: 2.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  1219 VCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYllagenlpPHQAEDARTQRQwRTLEAVRHVGVAIVSSAL 1298
Cdd:TIGR00921  231 VAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRY--------EEERDIGRAKGE-AIVTAVRRTGRAVLIALL 301

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 149274653  1299 TTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALL 1341
Cdd:TIGR00921  302 TTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALL 344
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
 1224-1344 7.62e-05

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 47.29  E-value: 7.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  1224 TIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEgyllageNLPPHQAEDARTQRQwRTLEAVRHVGVAIVSSALTTVIA 1303
Cdd:pfam00873  374 AVMKAFGFSINTLTLGGLVLAIGLVVDDAIVVVE-------NIERVLEENGLKPLE-AAYKSMGEIGGALVAIALVLSAV 445

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 149274653  1304 TVPLFF---CIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIM 1344
Cdd:pfam00873  446 FLPILFlggLTGRIFRQFAITIVLAILLSVLVALTLTPALCATL 489
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
431-616 4.81e-27

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 119.19  E-value: 4.81e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  431 AMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVAL-FLYhvV 509
Cdd:COG1033   188 AIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--L 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  510 FGIQyLGILNGVAAFVIVGIGVDDVFVFINTYRQAT-HLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVH 588
Cdd:COG1033   266 LGIP-LSPLTILVPPLLLAIGIDYGIHLLNRYREERrKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIR 344

                         170       180
                  ....*....|....*....|....*...
gi 149274653  589 DFGLFMSLIVSCCWLAVLVTMPAALGLW 616
Cdd:COG1033   345 DFGIVAAIGVLLAFLTSLTLLPALLSLL 372
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
386-616 8.35e-19

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 92.62  E-value: 8.35e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  386 SADNLKSSLLRSEILFGAPLPNYYSVD---------------DRWEEQRAKFQSFVVTYVAmlakqsTSKVQVLYGGTDL 450
Cdd:COG1033   521 SRELLAQLLLLLSSPPGDDLSRFVDEDysaarvtvrlkdldsEEIKALVEEVRAFLAENFP------PDGVEVTLTGSAV 594

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  451 FDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLScLVALFLYHVVFGIQyLGILNGVAAFVIVGIG 530
Cdd:COG1033   595 LFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLP-ILLTFGLMGLLGIP-LNIATAVVASIALGIG 672

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  531 VDDVFVFINTYRQA-THLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTM 609
Cdd:COG1033   673 VDYTIHFLSRYREErRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752


                  ....*..
gi 149274653  610 PAALGLW 616
Cdd:COG1033   753 PALLLLL 759
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1187-1344 5.04e-13

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 73.74  E-value: 5.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653 1187 LVLSLLICVAAVAVFTTHILLLLPvllsilGIVCLVVTI------MYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYL 1260
Cdd:COG1033   224 FPLALLLILLLLFLFFRSLRGVLL------PLLVVLLAViwtlglMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYR 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653 1261 -LAGENLPPHQAedARtqrqwrtlEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTA 1339
Cdd:COG1033   298 eERRKGLDKREA--LR--------EALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPA 367


                  ....*
gi 149274653 1340 LLGIM 1344
Cdd:COG1033   368 LLSLL 372
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 485-615 5.14e-13

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 67.99  E-value: 5.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   485 VFLSFFGIASIGLS--CLVALFLYhvvFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAG 562
Cdd:pfam12349    6 FGLGLAGVIIVLASvaSSLGLCAY---FGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGEVG 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 149274653   563 KATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:pfam12349   83 PSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSL 135
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 412-613 4.87e-12

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 70.85  E-value: 4.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   412 DDRWEEQRAKFqsFVVTYVAMLAKQSTSK-VQVLYGGTDLFDYEVRRtfNNDMLLAFISSSCIAALVYILTSCSVFLSFF 490
Cdd:pfam02460  166 DEEEVEEDSKE--WEDELSQLLHNKYASEhIQFTIFHDQILNDELVR--NALTLTPFFVIGFFLLLTFSIIVSVTLSSYT 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   491 -------------GIASIGLSCLVAL-FLYhvVFGIQYLGILNgVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIH 556
Cdd:pfam02460  242 idwvrskpilaalGLLSPVMAIVSSFgLLF--WMGFPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGE 318

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 149274653   557 TVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLvTMPAAL 613
Cdd:pfam02460  319 ALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQI-TFFAAI 374
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1218-1346 9.95e-12

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 69.89  E-value: 9.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653 1218 IVCLVVT--IMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLA-GENLPPHQAedartqrqwrTLEAVRHVGVAIV 1294
Cdd:COG1033   640 LLPILLTfgLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREErRKGGDLEEA----------IRRALRTTGKAIL 709

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 149274653 1295 SSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 1346
Cdd:COG1033   710 FTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDP 761
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 441-615 1.29e-10

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 66.01  E-value: 1.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   441 VQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALfLYHVVFGIQYLGILNG 520
Cdd:TIGR00921  547 VKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAI-GLMGLRGIPSFLAMAT 625

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   521 VAAfVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSC 600
Cdd:TIGR00921  626 TIS-IILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLS 704

                          170
                   ....*....|....*
gi 149274653   601 CWLAVLVTMPAALGL 615
Cdd:TIGR00921  705 SLTAALVVFPALLVL 719
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
407-615 7.25e-10

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 63.75  E-value: 7.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   407 NYYSVDDRWEEQRAKF------QSFVVTYVAMLAKQSTSKVQVlYGGTDLfdyevrrtfnNDMLLAFISSSCI----AAL 476
Cdd:TIGR00918  339 YYKVHHIGWNEEKAAAvleawqRNFSEEVQQSLPKNSSQKILV-FSSTTL----------DDILKKFSDVSAIrivsGYL 407

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   477 VYILTSCSVFL--------SFFGIASIGLSCL-VALFL-YHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATH 546
Cdd:TIGR00918  408 LMLAYACLTMLrwdcaksqGSVGLAGVLLVALsVAAGLgLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ 487

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 149274653   547 LEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:TIGR00918  488 NIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSL 556
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 426-615 8.14e-10

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 61.92  E-value: 8.14e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   426 VVTYVAMLAKQSTSKVQVlyGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSC-----L 500
Cdd:pfam03176  109 VRDAVEQAPPPEGLKAYL--TGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLgaaqgL 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   501 VALFLYHVVFGIQYLGIlnGVAAFVIVGIGVDDVFVFINTYRQATHL-EDPQLRMIHTVQTAGKATFFTSLTTAAAYAAN 579
Cdd:pfam03176  187 VAILAHILGIGLSTFAL--NLLVVLLIAVGTDYALFLVSRYREELRAgEDREEAVIRAVRGTGKVVTAAGLTVAIAMLAL 264

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 149274653   580 VFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:pfam03176  265 SFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 440-613 2.45e-09

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 61.78  E-value: 2.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   440 KVQVLYGGTDLfDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIAsiglsclVALFLYHVVFGIQ-YLGI- 517
Cdd:TIGR00921  173 KFLDVTGSPAI-NYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLV-------IILFGVAWVLGIMgWLGIp 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   518 ----LNGVAAfVIVGIGVDDVFVFINTYRQATHL-EDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGL 592
Cdd:TIGR00921  245 lyatTLLAVP-MLIGVGIDYGIQTLNRYEEERDIgRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGL 323

                          170       180
                   ....*....|....*....|.
gi 149274653   593 FMSLIVSCCWLAVLVTMPAAL 613
Cdd:TIGR00921  324 GLVAGLITAYLLTLLVLPALL 344
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 433-615 1.05e-08

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 59.78  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  433 LAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFF----GIASIGLSCLVALFLYHV 508
Cdd:COG2409   141 VAAAPAPGLTVYVTGPAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLplltAGLAVGVALGLLALLAAF 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  509 V-FGIQYLGIlngvaAFVIV-GIGVDDVFVFINTYRQA-THLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIP 585
Cdd:COG2409   221 TdVSSFAPNL-----LTMLGlGVGIDYALFLVSRYREElRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLP 295

                         170       180       190
                  ....*....|....*....|....*....|
gi 149274653  586 AVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:COG2409   296 FLRSMGPAAAIGVAVAVLAALTLLPALLAL 325
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 1219-1341 2.10e-07

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 55.61  E-value: 2.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  1219 VCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYllagenlpPHQAEDARTQRQwRTLEAVRHVGVAIVSSAL 1298
Cdd:TIGR00921  231 VAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRY--------EEERDIGRAKGE-AIVTAVRRTGRAVLIALL 301

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 149274653  1299 TTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALL 1341
Cdd:TIGR00921  302 TTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALL 344
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 449-614 3.68e-07

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 55.00  E-value: 3.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   449 DLFDYEVRRTFNNDMLLafISSSCIAALVYILTSCSV----FLSFFGIASIGLSCL----------VALFLYHVVFGIQY 514
Cdd:TIGR03480  675 DLNDNEALRRFVRAVRK--VAPDATGAPVSILESGDTvvgaFLQAFIYALVAITVLllltlrrvrdVLLVLAPLLLAGLL 752

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   515 LGIL-----------NGVAAFVIVGIGVDDVFVFINTYRQATHLEDPqlrmIHTvqTAGKATFFTSLTTAAAYAANVFSQ 583
Cdd:TIGR03480  753 TVAAmvllgipfnfaNIIALPLLLGLGVDFGIYMVHRWRNGVDSGNL----LQS--STARAVFFSALTTATAFGSLAVSS 826

                          170       180       190
                   ....*....|....*....|....*....|.
gi 149274653   584 IPAVHDFGLFMSLIVSCCWLAVLVTMPAALG 614
Cdd:TIGR03480  827 HPGTASMGILLSLGLGLTLLCTLIFLPALLG 857
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 375-615 7.73e-07

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 54.14  E-value: 7.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   375 PEFYWYVDEGLSADNLKSSllrSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQvlYGGTDLFDYE 454
Cdd:TIGR00917  491 PVDPTTVLGGFSGNNFSEA---SAFVVTFPVNNFVNKTNKTEKAVAWEKAFIQLAKDELLPMVQATIS--FSAERSIEDE 565

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   455 VRRTFNNDM---------LLAFISSSC--IAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVfGIQYLGILNGVAA 523
Cdd:TIGR00917  566 LKRESTADVitiaisylvMFAYISLTLgdSPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAV-GLKSTLIIMEVIP 644

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   524 FVIVGIGVDDVFVFINTY------RQATHLEDPQL-----RMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGL 592
Cdd:TIGR00917  645 FLVLAVGVDNIFILVFFYfyleyfYRQVGVDNEQEltlerRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSM 724

                          250       260
                   ....*....|....*....|...
gi 149274653   593 FMSLIVSCCWLAVLVTMPAALGL 615
Cdd:TIGR00917  725 FAVLAVFLDFLLQITAFVALLVL 747
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 1217-1341 2.04e-06

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 52.53  E-value: 2.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  1217 GIVCLVVTIMyWSGWEMGA-------VEAISLSILVGSSVDYCVHLVEGYLlagENLPPHQAEDArtqrqWRTleAVRHV 1289
Cdd:TIGR00921  597 PLIAIGSGIL-WAIGLMGLrgipsflAMATTISIILGLGMDYSIHLAERYF---EERKEHGPKEA-----ITH--TMERT 665

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 149274653  1290 GVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALL 1341
Cdd:TIGR00921  666 GPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALL 717
COG4258 COG4258
Predicted exporter [General function prediction only];
434-612 2.50e-06

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 52.16  E-value: 2.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  434 AKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGiq 513
Cdd:COG4258   222 LNAAFPGAQLLLTGAGLFAVAAAQQIKHDISTIGLISLLGILLLLLLVFRSLRPLLLGLLPVAVGALAGLAAVSLVFG-- 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  514 YLGILNGVAAFVIVGIGVDDVFVFInTYRQATHLEDPQlrmiHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLF 593
Cdd:COG4258   300 SVHGITLGFGSSLIGVAVDYSLHYL-THRRAAGEWDPR----AALRRIWPTLLLGLLTTVLGYLALLFSPFPGLRQLGVF 374

                         170       180
                  ....*....|....*....|....*
gi 149274653  594 --MSLIVSC----CWLAVLVTMPAA 612
Cdd:COG4258   375 aaAGLLAAAlttlLWLPLLLPRAAP 399
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 1239-1356 4.80e-06

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 51.12  E-value: 4.80e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  1239 ISLSILVGSSVDYCVHLVEGYLlagENLPPHQAEDARTQrqwrtlEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKF 1318
Cdd:TIGR00833  236 LLTALVIGAGTDYAVFLTGRYH---EERRKGESLEEAAA------EALRGTGKAILGSALTVAVAFLALSLARLPSFKTL 306

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 149274653  1319 GKIVALNTGVSILYTLTVSTALL------GIMAPSSFTRTRTSF 1356
Cdd:TIGR00833  307 GVSCAVGVLVALLNAVTLTPALLtlegreGLMKPGRKSKIRFIW 350
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
 1224-1344 7.62e-05

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 47.29  E-value: 7.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  1224 TIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEgyllageNLPPHQAEDARTQRQwRTLEAVRHVGVAIVSSALTTVIA 1303
Cdd:pfam00873  374 AVMKAFGFSINTLTLGGLVLAIGLVVDDAIVVVE-------NIERVLEENGLKPLE-AAYKSMGEIGGALVAIALVLSAV 445

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 149274653  1304 TVPLFF---CIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIM 1344
Cdd:pfam00873  446 FLPILFlggLTGRIFRQFAITIVLAILLSVLVALTLTPALCATL 489
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 1218-1347 6.69e-04

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 44.22  E-value: 6.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  1218 IVCLVVTiMYWSGWEMGAVEAISLS---ILVGSSVDYCVHLVEGY---LLAGENLPphQAedartqrqwrTLEAVRHVGV 1291
Cdd:TIGR03480  304 IVGLILT-AAFATLAVGHLNLISVAfavLFIGLGVDFAIQFSLRYreeRFRGGNHR--EA----------LSVAARRMGA 370

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  1292 AIVSSALTTVIAtvplFFCII----APFAKFGKIVALNTGVSILYTLTVSTALLGIMAPS 1347
Cdd:TIGR03480  371 ALLLAALATAAG----FFAFLptdyKGVSELGIIAGTGMFIALFVTLTVLPALLRLLRPP 426
COG4258 COG4258
Predicted exporter [General function prediction only];
474-611 7.72e-04

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 44.07  E-value: 7.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  474 AALVYILTSCSVFLSFFGI-------ASIGLSCLVALFLYhVVFGIQyLGILNGVAAFVIVGIGVD-DVFVfintyRQAT 545
Cdd:COG4258   645 LLLALLLILLLLLLRLRSLrralrvlLPPLLAVLLTLAIL-GLLGIP-LNLFHLIALLLVLGIGIDyALFF-----TEGL 717

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149274653  546 HLEDPQLRMIHTVqtagkatFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPA 611
Cdd:COG4258   718 LDKGELARTLLSI-------LLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLLAPLLAPR 776
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 1180-1346 8.43e-04

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 43.88  E-value: 8.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  1180 VQSALCGLVLSLLICVAAVA-VFTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEG 1258
Cdd:pfam02460  637 ILPSTIQNIVITLICMFIVCfLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYH 716

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  1259 YLLAGENLPphqaedarTQRQWRTLEAvrhVGVAIVSSALTTVIATVPLFFC---IIAPFAkfgKIVALNTGVSILYTLT 1335
Cdd:pfam02460  717 FVRSRGDTP--------AERVVDALEA---LGWPVFQGGLSTILGVLVLLFVpsyMVVVFF---KTVFLVVAIGLLHGLF 782

                          170
                   ....*....|.
gi 149274653  1336 VSTALLGIMAP 1346
Cdd:pfam02460  783 ILPIILSLFVT 793
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 437-616 1.63e-03

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 43.06  E-value: 1.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   437 STSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTscsvFLSFFGIASIgLSCLVALFLYHVVFGIQYLG 516
Cdd:TIGR03480  245 EDHGVTVRLTGEVALSDEELATVSEGATVAGLLSFVLVLVLLWLA----LRSPRLVFAV-LVTLIVGLILTAAFATLAVG 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   517 ILNGVA-AFVI--VGIGVDDVFVFINTYRQATHLEDPQLRMIH-TVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGL 592
Cdd:TIGR03480  320 HLNLISvAFAVlfIGLGVDFAIQFSLRYREERFRGGNHREALSvAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGI 399

                          170       180
                   ....*....|....*....|....
gi 149274653   593 FMSLIVSCCWLAVLVTMPAALGLW 616
Cdd:TIGR03480  400 IAGTGMFIALFVTLTVLPALLRLL 423
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 1239-1343 2.09e-03

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 42.45  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653 1239 ISLSILVGSSVDYCVHLVEGY---LLAGENlpPHQAedARTqrqwrtleAVRHVGVAIVSSALTTVIATVPLFFCIIAPF 1315
Cdd:COG2409   230 LLTMLGLGVGIDYALFLVSRYreeLRAGED--REEA--VAR--------AVATAGRAVLFSGLTVAIALLGLLLAGLPFL 297

                          90       100
                  ....*....|....*....|....*...
gi 149274653 1316 AKFGKIVALNTGVSILYTLTVSTALLGI 1343
Cdd:COG2409   298 RSMGPAAAIGVAVAVLAALTLLPALLAL 325
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 1238-1353 2.36e-03

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 41.89  E-value: 2.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653  1238 AISLSILVGSSVDYCVHLVEGY---LLAGENlpphQAEDARTqrqwrtleAVRHVGVAIVSSALTTVIATVPLFFCIIAP 1314
Cdd:pfam03176  204 NLLVVLLIAVGTDYALFLVSRYreeLRAGED----REEAVIR--------AVRGTGKVVTAAGLTVAIAMLALSFARLPV 271

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 149274653  1315 FAKFGKIVALNTGVSILYTLTVSTALLGIMAPSSFTRTR 1353
Cdd:pfam03176  272 FAQVGPTIAIGVLVDVLAALTLLPALLALLGRWGLWPPK 310
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 459-617 8.36e-03

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 40.72  E-value: 8.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   459 FNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALflyHVVFGIQYLGILnGVAAF-------VIVGIGV 531
Cdd:TIGR00833  171 GDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQ---GIVSLLGIPGLI-GVNAQttvlltaLVIGAGT 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274653   532 DDVFVFINTYRQAT-HLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMP 610
Cdd:TIGR00833  247 DYAVFLTGRYHEERrKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTP 326


                   ....*..
gi 149274653   611 AALGLWS 617
Cdd:TIGR00833  327 ALLTLEG 333
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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