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Conserved domains on  [gi|1937886713|ref|NP_062051|]
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toll-like receptor 4 precursor [Rattus norvegicus]

Protein Classification

toll-like receptor( domain architecture ID 13320297)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
672-813 1.49e-33

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 125.90  E-value: 1.49e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  672 YDAFVIYSSQneDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANIIqEGFHKSRKVIVVVSRHFIQSRWCIFEYEI 751
Cdd:smart00255   2 YDVFISYSGK--EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEID-EAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1937886713  752 AQTWQFLSSRSGIIFIVLEkVEKSLLRQQVELYRLLSRNTYLEWEDNALGRhiFWRRLKKAL 813
Cdd:smart00255  79 ALENALEEGGLRVIPIFYE-VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQ--FWKKALYAV 137
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
370-578 9.35e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 9.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 370 LPSLRYLDLSRNAMSFRgccsysdfgTNNLKYLDLSFNGVILMSANFMGLEELEYLDFQHSTLKKVTEfsVFLSLEKLLY 449
Cdd:COG4886    95 LTNLTELDLSGNEELSN---------LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKS 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 450 LDISYTNTKiDFDGIFLGLISLNTLKMAGNSFKDntLSNVFTNTTNLTFLDLSKCQLEQISRGvFDTLYRLQLLNMSHNN 529
Cdd:COG4886   164 LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQ 239

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1937886713 530 LlfLDPSHYKQLYSLRTLDCSFNRIETSKGILQHfpKSLAVFNLTNNSV 578
Cdd:COG4886   240 L--TDLPELGNLTNLEELDLSNNQLTDLPPLANL--TNLKTLDLSNNQL 284
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 23-456 3.24e-11

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 3.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  23 GSLNPCIEVLPNI-TYQCMDQNLS-KIPHDI---PYSTKNLDLSFNPLKilRSYSFSNFSQLQWLDLSRCEIETIEDKAW 97
Cdd:PLN00113   83 GKISSAIFRLPYIqTINLSNNQLSgPIPDDIfttSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNMLSGEIPNDI 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  98 HGLNQLSTLVLTGNPIKSFSPGSFSGLTNLENLVAVETKMTSLEGFHIGQLISLKKLNVAHNLIhSFKLPEYFSNLTNLE 177
Cdd:PLN00113  161 GSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLN 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 178 HVDLSYNYIQTI------SVKDLQ--FLRENpqvNLSldlslnpiDSIQAQAFQGIRLHELTLRSNFNSSNV--LKMCLQ 247
Cdd:PLN00113  240 HLDLVYNNLTGPipsslgNLKNLQylFLYQN---KLS--------GPIPPSIFSLQKLISLDLSDNSLSGEIpeLVIQLQ 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 248 NMTGLHVhrlilgeFKNErnlesFDRSVMEGLCNVSIDEFRLTYINHFSDDI-------YNLNCLaNISAMSFTGVHIKH 320
Cdd:PLN00113  309 NLEILHL-------FSNN-----FTGKIPVALTSLPRLQVLQLWSNKFSGEIpknlgkhNNLTVL-DLSTNNLTGEIPEG 375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 321 IADVPRHFKW------------------QSLSIIRCHLKPFP-KLS-----LPFLKSWTLTTNR--EDISFGQLALPSLR 374
Cdd:PLN00113  376 LCSSGNLFKLilfsnslegeipkslgacRSLRRVRLQDNSFSgELPseftkLPLVYFLDISNNNlqGRINSRKWDMPSLQ 455

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 375 YLDLSRNamSFRGCCSYSdFGTNNLKYLDLS---FNGVILMSanFMGLEELEYLDFQHSTLKKV--TEFSvflSLEKLLY 449
Cdd:PLN00113  456 MLSLARN--KFFGGLPDS-FGSKRLENLDLSrnqFSGAVPRK--LGSLSELMQLKLSENKLSGEipDELS---SCKKLVS 527


                  ....*..
gi 1937886713 450 LDISYTN 456
Cdd:PLN00113  528 LDLSHNQ 534
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
672-813 1.49e-33

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 125.90  E-value: 1.49e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  672 YDAFVIYSSQneDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANIIqEGFHKSRKVIVVVSRHFIQSRWCIFEYEI 751
Cdd:smart00255   2 YDVFISYSGK--EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEID-EAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1937886713  752 AQTWQFLSSRSGIIFIVLEkVEKSLLRQQVELYRLLSRNTYLEWEDNALGRhiFWRRLKKAL 813
Cdd:smart00255  79 ALENALEEGGLRVIPIFYE-VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQ--FWKKALYAV 137
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 675-821 2.94e-30

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 117.08  E-value: 2.94e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 675 FVIYSS----QNEDWVRNELVKNLeeGVPRFQLCLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSRHFIQSRWCIFEYE 750
Cdd:pfam01582   1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 751 IAQTWQfLSSRSGIIFIVLEKVEK-------SLLRQQVELYRLLSRNTYLEWE------------DNALGRHIFWRRLKK 811
Cdd:pfam01582  78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156

                         170
                  ....*....|
gi 1937886713 812 ALLdgKALNP 821
Cdd:pfam01582 157 DIS--NKLNG 164
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
370-578 9.35e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 9.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 370 LPSLRYLDLSRNAMSFRgccsysdfgTNNLKYLDLSFNGVILMSANFMGLEELEYLDFQHSTLKKVTEfsVFLSLEKLLY 449
Cdd:COG4886    95 LTNLTELDLSGNEELSN---------LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKS 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 450 LDISYTNTKiDFDGIFLGLISLNTLKMAGNSFKDntLSNVFTNTTNLTFLDLSKCQLEQISRGvFDTLYRLQLLNMSHNN 529
Cdd:COG4886   164 LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQ 239

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1937886713 530 LlfLDPSHYKQLYSLRTLDCSFNRIETSKGILQHfpKSLAVFNLTNNSV 578
Cdd:COG4886   240 L--TDLPELGNLTNLEELDLSNNQLTDLPPLANL--TNLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 23-456 3.24e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 3.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  23 GSLNPCIEVLPNI-TYQCMDQNLS-KIPHDI---PYSTKNLDLSFNPLKilRSYSFSNFSQLQWLDLSRCEIETIEDKAW 97
Cdd:PLN00113   83 GKISSAIFRLPYIqTINLSNNQLSgPIPDDIfttSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNMLSGEIPNDI 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  98 HGLNQLSTLVLTGNPIKSFSPGSFSGLTNLENLVAVETKMTSLEGFHIGQLISLKKLNVAHNLIhSFKLPEYFSNLTNLE 177
Cdd:PLN00113  161 GSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLN 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 178 HVDLSYNYIQTI------SVKDLQ--FLRENpqvNLSldlslnpiDSIQAQAFQGIRLHELTLRSNFNSSNV--LKMCLQ 247
Cdd:PLN00113  240 HLDLVYNNLTGPipsslgNLKNLQylFLYQN---KLS--------GPIPPSIFSLQKLISLDLSDNSLSGEIpeLVIQLQ 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 248 NMTGLHVhrlilgeFKNErnlesFDRSVMEGLCNVSIDEFRLTYINHFSDDI-------YNLNCLaNISAMSFTGVHIKH 320
Cdd:PLN00113  309 NLEILHL-------FSNN-----FTGKIPVALTSLPRLQVLQLWSNKFSGEIpknlgkhNNLTVL-DLSTNNLTGEIPEG 375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 321 IADVPRHFKW------------------QSLSIIRCHLKPFP-KLS-----LPFLKSWTLTTNR--EDISFGQLALPSLR 374
Cdd:PLN00113  376 LCSSGNLFKLilfsnslegeipkslgacRSLRRVRLQDNSFSgELPseftkLPLVYFLDISNNNlqGRINSRKWDMPSLQ 455

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 375 YLDLSRNamSFRGCCSYSdFGTNNLKYLDLS---FNGVILMSanFMGLEELEYLDFQHSTLKKV--TEFSvflSLEKLLY 449
Cdd:PLN00113  456 MLSLARN--KFFGGLPDS-FGSKRLENLDLSrnqFSGAVPRK--LGSLSELMQLKLSENKLSGEipDELS---SCKKLVS 527


                  ....*..
gi 1937886713 450 LDISYTN 456
Cdd:PLN00113  528 LDLSHNQ 534
LRR_8 pfam13855
Leucine rich repeat;
56-113 2.98e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.98e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1937886713  56 KNLDLSFNPLKILRSYSFSNFSQLQWLDLSRCEIETIEDKAWHGLNQLSTLVLTGNPI 113
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-235 8.21e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 8.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  34 NITYQCMDQNLSKIPHDIPYSTKNLDLSFNPLKILRSYSFSNFSQLQWLDLSRcEIETIEDKAWHGLNQLSTLVLTGNPI 113
Cdd:COG4886     6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLR-DLLLSSLLLLLSLLLLLLLSLLLLSL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 114 KSFSPGSFSGLTNLENLVAVETKmtslegfHIGQLISLKKLNVAHNLIHSfkLPEYFSNLTNLEHVDLSYNYIQTI--SV 191
Cdd:COG4886    85 LLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLpePL 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1937886713 192 KDLQFLRenpqvnlSLDLSLNPIDSIQAQAFQGIRLHELTLRSN 235
Cdd:COG4886   156 GNLTNLK-------SLDLSNNQLTDLPEELGNLTNLKELDLSNN 192
LRR_8 pfam13855
Leucine rich repeat;
494-554 1.83e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.83e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1937886713 494 TNLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQLYSLRTLDCSFNRI 554
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 41-214 3.86e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 3.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  41 DQNLSKIPhdipystkNLDLSFNpLKILRSYS--------FSNFSQLQWLDLSRCEIETIEDkaWHGLNQLSTLVLTGNP 112
Cdd:cd21340    11 DKNITKID--------NLSLCKN-LKVLYLYDnkitkienLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 113 IKSFSpgsfsGLTNLENL---------VAVETKMTSLEGFHIGQLISLKKLNVAHNLIHSfklPEYFSNLTNLEHVDLSY 183
Cdd:cd21340    80 ISVVE-----GLENLTNLeelhienqrLPPGEKLTFDPRSLAALSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASN 151

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1937886713 184 NYIQtiSVKDL-QFLRENPQVNlSLDLSLNPI 214
Cdd:cd21340   152 NQIS--DLEELlDLLSSWPSLR-ELDLTGNPV 180
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 369-555 1.74e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 369 ALPSLRYLDLSRNAMSFRGCCSYSDFGTNN-LKYLDLSFNGvilmsanfmglEELEYLDFQHSTLKkvtefSVFLSLEKL 447
Cdd:cd00116    79 KGCGLQELDLSDNALGPDGCGVLESLLRSSsLQELKLNNNG-----------LGDRGLRLLAKGLK-----DLPPALEKL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 448 LYLDISYTNTK-IDFDGIFLGLISLNTLKMAGNSFKDN---TLSNVFTNTTNLTFLDLSKCQLE-----QISrGVFDTLY 518
Cdd:cd00116   143 VLGRNRLEGAScEALAKALRANRDLKELNLANNGIGDAgirALAEGLKANCNLEVLDLNNNGLTdegasALA-ETLASLK 221

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1937886713 519 RLQLLNMSHNNL-----LFLDPSHYKQLYSLRTLDCSFNRIE 555
Cdd:cd00116   222 SLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDIT 263
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
672-813 1.49e-33

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 125.90  E-value: 1.49e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  672 YDAFVIYSSQneDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANIIqEGFHKSRKVIVVVSRHFIQSRWCIFEYEI 751
Cdd:smart00255   2 YDVFISYSGK--EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEID-EAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1937886713  752 AQTWQFLSSRSGIIFIVLEkVEKSLLRQQVELYRLLSRNTYLEWEDNALGRhiFWRRLKKAL 813
Cdd:smart00255  79 ALENALEEGGLRVIPIFYE-VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQ--FWKKALYAV 137
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 675-821 2.94e-30

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 117.08  E-value: 2.94e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 675 FVIYSS----QNEDWVRNELVKNLeeGVPRFQLCLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSRHFIQSRWCIFEYE 750
Cdd:pfam01582   1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 751 IAQTWQfLSSRSGIIFIVLEKVEK-------SLLRQQVELYRLLSRNTYLEWE------------DNALGRHIFWRRLKK 811
Cdd:pfam01582  78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156

                         170
                  ....*....|
gi 1937886713 812 ALLdgKALNP 821
Cdd:pfam01582 157 DIS--NKLNG 164
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
370-578 9.35e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 9.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 370 LPSLRYLDLSRNAMSFRgccsysdfgTNNLKYLDLSFNGVILMSANFMGLEELEYLDFQHSTLKKVTEfsVFLSLEKLLY 449
Cdd:COG4886    95 LTNLTELDLSGNEELSN---------LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKS 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 450 LDISYTNTKiDFDGIFLGLISLNTLKMAGNSFKDntLSNVFTNTTNLTFLDLSKCQLEQISRGvFDTLYRLQLLNMSHNN 529
Cdd:COG4886   164 LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQ 239

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1937886713 530 LlfLDPSHYKQLYSLRTLDCSFNRIETSKGILQHfpKSLAVFNLTNNSV 578
Cdd:COG4886   240 L--TDLPELGNLTNLEELDLSNNQLTDLPPLANL--TNLKTLDLSNNQL 284
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 675-770 5.14e-12

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 63.49  E-value: 5.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 675 FVIYSSQNEDWVRnELVKNLEE-GvprFQLCLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAq 753
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAaG---YRVWLDRWDIRPGDDWVEEI-EEAIENSDRVLVVLSPNYLESPWCRAEWEAA- 75

                          90
                  ....*....|....*..
gi 1937886713 754 tWQFLSSRSGIIFIVLE 770
Cdd:pfam13676  76 -LADPEGRKRLIPVRLE 91
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 23-456 3.24e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 3.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  23 GSLNPCIEVLPNI-TYQCMDQNLS-KIPHDI---PYSTKNLDLSFNPLKilRSYSFSNFSQLQWLDLSRCEIETIEDKAW 97
Cdd:PLN00113   83 GKISSAIFRLPYIqTINLSNNQLSgPIPDDIfttSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNMLSGEIPNDI 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  98 HGLNQLSTLVLTGNPIKSFSPGSFSGLTNLENLVAVETKMTSLEGFHIGQLISLKKLNVAHNLIhSFKLPEYFSNLTNLE 177
Cdd:PLN00113  161 GSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLN 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 178 HVDLSYNYIQTI------SVKDLQ--FLRENpqvNLSldlslnpiDSIQAQAFQGIRLHELTLRSNFNSSNV--LKMCLQ 247
Cdd:PLN00113  240 HLDLVYNNLTGPipsslgNLKNLQylFLYQN---KLS--------GPIPPSIFSLQKLISLDLSDNSLSGEIpeLVIQLQ 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 248 NMTGLHVhrlilgeFKNErnlesFDRSVMEGLCNVSIDEFRLTYINHFSDDI-------YNLNCLaNISAMSFTGVHIKH 320
Cdd:PLN00113  309 NLEILHL-------FSNN-----FTGKIPVALTSLPRLQVLQLWSNKFSGEIpknlgkhNNLTVL-DLSTNNLTGEIPEG 375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 321 IADVPRHFKW------------------QSLSIIRCHLKPFP-KLS-----LPFLKSWTLTTNR--EDISFGQLALPSLR 374
Cdd:PLN00113  376 LCSSGNLFKLilfsnslegeipkslgacRSLRRVRLQDNSFSgELPseftkLPLVYFLDISNNNlqGRINSRKWDMPSLQ 455

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 375 YLDLSRNamSFRGCCSYSdFGTNNLKYLDLS---FNGVILMSanFMGLEELEYLDFQHSTLKKV--TEFSvflSLEKLLY 449
Cdd:PLN00113  456 MLSLARN--KFFGGLPDS-FGSKRLENLDLSrnqFSGAVPRK--LGSLSELMQLKLSENKLSGEipDELS---SCKKLVS 527


                  ....*..
gi 1937886713 450 LDISYTN 456
Cdd:PLN00113  528 LDLSHNQ 534
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
370-600 1.36e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 370 LPSLRYLDLSRNAMSFRGccsySDFGT-NNLKYLDLSFNGVILMSANFMGLEELEYLDFQHStlkKVTEFSVFLS-LEKL 447
Cdd:COG4886   135 LTNLKELDLSNNQLTDLP----EPLGNlTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN---QITDLPEPLGnLTNL 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 448 LYLDISYTNTKiDFDGIFLGLISLNTLKMAGNSFKDntLSNvFTNTTNLTFLDLSKCQLEQISrgVFDTLYRLQLLNMSH 527
Cdd:COG4886   208 EELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLTD--LPE-LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSN 281

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1937886713 528 NNLLFLDPSHYKQLYSLRTLDCSFNRIETSKGILQHFPKSLAVFNLTNNSVACICEYQNFLQWVKDQKMFLVN 600
Cdd:COG4886   282 NQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354
LRR_8 pfam13855
Leucine rich repeat;
56-113 2.98e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.98e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1937886713  56 KNLDLSFNPLKILRSYSFSNFSQLQWLDLSRCEIETIEDKAWHGLNQLSTLVLTGNPI 113
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
331-531 6.26e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 6.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 331 QSLSIIRCHLKPFPKL--SLPFLKSWTLTTNR-EDISFGQLALPSLRYLDLSRNAMSfrgCCSYSDFGTNNLKYLDLSFN 407
Cdd:COG4886   116 ESLDLSGNQLTDLPEElaNLTNLKELDLSNNQlTDLPEPLGNLTNLKSLDLSNNQLT---DLPEELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 408 GVILMSANFMGLEELEYLDFQHStlkKVTEFSVFLS-LEKLLYLDISYTN-TKIDFdgiFLGLISLNTLKMAGNSFKDNT 485
Cdd:COG4886   193 QITDLPEPLGNLTNLEELDLSGN---QLTDLPEPLAnLTNLETLDLSNNQlTDLPE---LGNLTNLEELDLSNNQLTDLP 266

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1937886713 486 LSnvfTNTTNLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNLL 531
Cdd:COG4886   267 PL---ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-235 8.21e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 8.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  34 NITYQCMDQNLSKIPHDIPYSTKNLDLSFNPLKILRSYSFSNFSQLQWLDLSRcEIETIEDKAWHGLNQLSTLVLTGNPI 113
Cdd:COG4886     6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLR-DLLLSSLLLLLSLLLLLLLSLLLLSL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 114 KSFSPGSFSGLTNLENLVAVETKmtslegfHIGQLISLKKLNVAHNLIHSfkLPEYFSNLTNLEHVDLSYNYIQTI--SV 191
Cdd:COG4886    85 LLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLpePL 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1937886713 192 KDLQFLRenpqvnlSLDLSLNPIDSIQAQAFQGIRLHELTLRSN 235
Cdd:COG4886   156 GNLTNLK-------SLDLSNNQLTDLPEELGNLTNLKELDLSNN 192
LRR_8 pfam13855
Leucine rich repeat;
77-130 6.53e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 6.53e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1937886713  77 SQLQWLDLSRCEIETIEDKAWHGLNQLSTLVLTGNPIKSFSPGSFSGLTNLENL 130
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYL 54
LRR_8 pfam13855
Leucine rich repeat;
494-554 1.83e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.83e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1937886713 494 TNLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQLYSLRTLDCSFNRI 554
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 41-214 3.86e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 3.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  41 DQNLSKIPhdipystkNLDLSFNpLKILRSYS--------FSNFSQLQWLDLSRCEIETIEDkaWHGLNQLSTLVLTGNP 112
Cdd:cd21340    11 DKNITKID--------NLSLCKN-LKVLYLYDnkitkienLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 113 IKSFSpgsfsGLTNLENL---------VAVETKMTSLEGFHIGQLISLKKLNVAHNLIHSfklPEYFSNLTNLEHVDLSY 183
Cdd:cd21340    80 ISVVE-----GLENLTNLeelhienqrLPPGEKLTFDPRSLAALSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASN 151

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1937886713 184 NYIQtiSVKDL-QFLRENPQVNlSLDLSLNPI 214
Cdd:cd21340   152 NQIS--DLEELlDLLSSWPSLR-ELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
150-214 1.57e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.57e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1937886713 150 SLKKLNVAHNLIHSFKlPEYFSNLTNLEHVDLSYNYIQTISVKDLQFLRenpqvNL-SLDLSLNPI 214
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-----SLrYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 369-555 1.74e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 369 ALPSLRYLDLSRNAMSFRGCCSYSDFGTNN-LKYLDLSFNGvilmsanfmglEELEYLDFQHSTLKkvtefSVFLSLEKL 447
Cdd:cd00116    79 KGCGLQELDLSDNALGPDGCGVLESLLRSSsLQELKLNNNG-----------LGDRGLRLLAKGLK-----DLPPALEKL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 448 LYLDISYTNTK-IDFDGIFLGLISLNTLKMAGNSFKDN---TLSNVFTNTTNLTFLDLSKCQLE-----QISrGVFDTLY 518
Cdd:cd00116   143 VLGRNRLEGAScEALAKALRANRDLKELNLANNGIGDAgirALAEGLKANCNLEVLDLNNNGLTdegasALA-ETLASLK 221

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1937886713 519 RLQLLNMSHNNL-----LFLDPSHYKQLYSLRTLDCSFNRIE 555
Cdd:cd00116   222 SLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDIT 263
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 78-235 2.85e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.40  E-value: 2.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  78 QLQWLDLSRCEI--ETIED--KAWHGLNQLSTLVLTGNPIKSFSPGSF----SGLTNLENLVAVETKMTSlEGFHIgqli 149
Cdd:COG5238   181 SVETVYLGCNQIgdEGIEElaEALTQNTTVTTLWLKRNPIGDEGAEILaealKGNKSLTTLDLSNNQIGD-EGVIA---- 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 150 slkklnvahnlihsfkLPEYFSNLTNLEHVDLSYNYIQTISVKDL-QFLRENPQVNlSLDLSLNPIDSIQAQAF-QGIR- 226
Cdd:COG5238   256 ----------------LAEALKNNTTVETLYLSGNQIGAEGAIALaKALQGNTTLT-SLDLSVNRIGDEGAIALaEGLQg 318

                         170
                  ....*....|..
gi 1937886713 227 ---LHELTLRSN 235
Cdd:COG5238   319 nktLHTLNLAYN 330
LRR_8 pfam13855
Leucine rich repeat;
102-186 3.11e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 102 QLSTLVLTGNPIKSFSPGSFSGLTNLenlvavetkmtslegfhigqlislKKLNVAHNLIHSFkLPEYFSNLTNLEHVDL 181
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNL------------------------KVLDLSNNLLTTL-SPGAFSGLPSLRYLDL 56


                  ....*
gi 1937886713 182 SYNYI 186
Cdd:pfam13855  57 SGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 490-579 7.67e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 7.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 490 FTNTTNLTFLDLSK------CQLEQISRGVFDTLYRLQLLNMSHNNLLFLDPSHYkqLYSLRTLDCSFNRIETSKGILQH 563
Cdd:cd21340    86 LENLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNIDSLEPLAP--LRNLEQLDASNNQISDLEELLDL 163

                          90
                  ....*....|....*...
gi 1937886713 564 FPK--SLAVFNLTNNSVA 579
Cdd:cd21340   164 LSSwpSLRELDLTGNPVC 181
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 58-235 8.17e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 8.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  58 LDLSFNPLK----ILRSYSFSNFSQLQWLDLS--RCEIETIE--DKAWHGLNQLSTLVLTGNPIksfspgSFSGLTNLEN 129
Cdd:COG5238   241 LDLSNNQIGdegvIALAEALKNNTTVETLYLSgnQIGAEGAIalAKALQGNTTLTSLDLSVNRI------GDEGAIALAE 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713 130 lvavetkmtSLEGFHIgqlisLKKLNVAHNLIHS---FKLPEYFSNLTNLEHVDLSYNYIQTISVKDL-QFLRENPQVnL 205
Cdd:COG5238   315 ---------GLQGNKT-----LHTLNLAYNGIGAqgaIALAKALQENTTLHSLDLSDNQIGDEGAIALaKYLEGNTTL-R 379

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1937886713 206 SLDLSLNPIDSIQAQAF----QGIRLHELTLRSN 235
Cdd:COG5238   380 ELNLGKNNIGKQGAEALidalQTNRLHTLILDGN 413
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 56-162 1.93e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937886713  56 KNLDLSFNPLKILRSYSFSNFSQLQWLDLSRCEIETIEDKAWHGLNQLSTLVLTGNPIKSFSPGSFSGLTNLENLVAVET 135
Cdd:PLN00113  478 ENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN 557

                          90       100
                  ....*....|....*....|....*..
gi 1937886713 136 KMTSLEGFHIGQLISLKKLNVAHNLIH 162
Cdd:PLN00113  558 QLSGEIPKNLGNVESLVQVNISHNHLH 584
LRR_8 pfam13855
Leucine rich repeat;
519-576 2.76e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1937886713 519 RLQLLNMSHNNLLFLDPSHYKQLYSLRTLDCSFNRIET-SKGILQHFPkSLAVFNLTNN 576
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTlSPGAFSGLP-SLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
490-530 9.47e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 9.47e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1937886713 490 FTNTTNLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNL 530
Cdd:pfam13855  21 FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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