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Conserved domains on  [gi|9256582|ref|NP_061723|]
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protocadherin alpha-1 isoform 1 precursor [Homo sapiens]

Protein Classification

protocadherin( domain architecture ID 13228192)

protocadherin is a transmembrane protein belonging to the cadherin superfamily and may be a calcium-dependent cell-adhesion protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 800-916 2.71e-70

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


:

Pssm-ID: 435046  Cd Length: 134  Bit Score: 229.14  E-value: 2.71e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582    800 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 878
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 9256582    879 SGPGELPDKFIIPGSPAIISIRQEPTNSQiDKSDFITF 916
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-346 6.41e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.20  E-value: 6.41e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  246 VYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGisrDIQEKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDK 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 9256582  326 GSPPMSNHCKVLVKVLDVNDN 346
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 8.23e-31

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 116.09  E-value: 8.23e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582     30 QLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELI 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 9256582    110 AD 111
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 459-561 5.61e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 5.61e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  459 EYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVgeralSNYVSVHAESGKVYALQPLDHEELELLQFQVSAR 538
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 9256582  539 DAGVPPLGSNVTLQVFVLDENDN 561
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-451 2.17e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 2.17e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  354 SLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSP 433
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 9256582  434 SLWATARVSVEVADVNDN 451
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 8.55e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 8.55e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  137 EQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSD---YFSLDveasdelSKSLWLELRKYLDREETPELHLLLT 213
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSID-------PSTGEITTAKPLDREEQSSYTLTVT 73

                        90       100
                ....*....|....*....|....*
gi 9256582  214 ATDGGKPELQGTVELLITVLDVNDN 238
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 577-670 3.83e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.83e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  577 VSELVPrlvgAGHVVAKVRAVDADSGYNAWLSYELQPaaGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGE 656
Cdd:cd11304   6 VPENAP----PGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....
gi 9256582  657 PALTATATVLVSLV 670
Cdd:cd11304  80 PPLSSTATVTITVL 93
 
Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 800-916 2.71e-70

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 229.14  E-value: 2.71e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582    800 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 878
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 9256582    879 SGPGELPDKFIIPGSPAIISIRQEPTNSQiDKSDFITF 916
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-346 6.41e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.20  E-value: 6.41e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  246 VYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGisrDIQEKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDK 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 9256582  326 GSPPMSNHCKVLVKVLDVNDN 346
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 8.23e-31

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 116.09  E-value: 8.23e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582     30 QLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELI 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 9256582    110 AD 111
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 459-561 5.61e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 5.61e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  459 EYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVgeralSNYVSVHAESGKVYALQPLDHEELELLQFQVSAR 538
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 9256582  539 DAGVPPLGSNVTLQVFVLDENDN 561
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-451 2.17e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 2.17e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  354 SLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSP 433
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 9256582  434 SLWATARVSVEVADVNDN 451
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-348 2.12e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 103.20  E-value: 2.12e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582     265 NASDADEGVNGEVVFSFDSGisrDIQEKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVN 344
Cdd:smart00112   1 SATDADSGENGKVTYSILSG---NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 9256582     345 DNAP 348
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 8.55e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 8.55e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  137 EQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSD---YFSLDveasdelSKSLWLELRKYLDREETPELHLLLT 213
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSID-------PSTGEITTAKPLDREEQSSYTLTVT 73

                        90       100
                ....*....|....*....|....*
gi 9256582  214 ATDGGKPELQGTVELLITVLDVNDN 238
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 577-670 3.83e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.83e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  577 VSELVPrlvgAGHVVAKVRAVDADSGYNAWLSYELQPaaGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGE 656
Cdd:cd11304   6 VPENAP----PGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....
gi 9256582  657 PALTATATVLVSLV 670
Cdd:cd11304  80 PPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
247-341 3.98e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.51  E-value: 3.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582    247 YRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIqekFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKG 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN---FRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 9256582    327 SPPMSNHCKVLVKVL 341
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 478-563 9.55e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 9.55e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582     478 SARDADAQENALVSYSLVERRVGeralsNYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLD 557
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 9256582     558 ENDNAP 563
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 1.49e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.63  E-value: 1.49e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582     157 AADADIGANALLTYTLSPSD---YFSLDveasdelSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVL 233
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNddgLFSID-------PETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 9256582     234 DVNDNAP 240
Cdd:smart00112  75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 373-453 2.79e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.86  E-value: 2.79e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582     373 TVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 9256582     453 P 453
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 595-670 1.55e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 1.55e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9256582     595 RAVDADSGYNAWLSYELQPaaGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGEPALTATATVLVSLV 670
Cdd:smart00112   1 SATDADSGENGKVTYSILS--GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
575-669 2.27e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.33  E-value: 2.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582    575 GAVSELVPRlvgaGHVVAKVRAVDADSGYNAWLSYELQPaaGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDH 654
Cdd:pfam00028   3 ASVPENAPV----GTEVLTVTATDPDLGPNGRIFYSILG--GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 9256582    655 GEPALTATATVLVSL 669
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
460-556 6.44e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 6.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582    460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGeralsNYVSVHAESGKVYALQPLDHEELELLQFQVSARD 539
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG-----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 9256582    540 AGVPPLGSNVTLQVFVL 556
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
359-445 4.98e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 4.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582    359 IREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWAT 438
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 9256582    439 ARVSVEV 445
Cdd:pfam00028  85 ATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 1.99e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.18  E-value: 1.99e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582   32 HYSIPEEAKHGTFVGRV-AQDLGLELAELVprLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWsaecsiHLELIA 110
Cdd:cd11304   3 EVSVPENAPPGTVVLTVsATDPDSGENGEV--TYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSY------TLTVTA 74

                        90       100
                ....*....|....*....|....
gi 9256582  111 -DRPLQVF----HVEVKVKDINDN 129
Cdd:cd11304  75 tDGGGPPLsstaTVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
140-233 7.59e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 7.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582    140 IFIPESRLLNSRFPIEGAADADIGANALLTYTLS---PSDYFSLDVEasdelskSLWLELRKYLDREETPELHLLLTATD 216
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPD-------TGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 9256582    217 GGKPELQGTVELLITVL 233
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 64-131 4.10e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.42  E-value: 4.10e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9256582      64 FRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWsaecsiHLELIA----DRPLQVF-HVEVKVKDINDNPP 131
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPEY------TLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 800-916 2.71e-70

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 229.14  E-value: 2.71e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582    800 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 878
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 9256582    879 SGPGELPDKFIIPGSPAIISIRQEPTNSQiDKSDFITF 916
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-346 6.41e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.20  E-value: 6.41e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  246 VYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGisrDIQEKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDK 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 9256582  326 GSPPMSNHCKVLVKVLDVNDN 346
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 8.23e-31

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 116.09  E-value: 8.23e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582     30 QLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELI 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 9256582    110 AD 111
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 459-561 5.61e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 5.61e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  459 EYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVgeralSNYVSVHAESGKVYALQPLDHEELELLQFQVSAR 538
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 9256582  539 DAGVPPLGSNVTLQVFVLDENDN 561
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-451 2.17e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 2.17e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  354 SLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSP 433
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 9256582  434 SLWATARVSVEVADVNDN 451
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-348 2.12e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 103.20  E-value: 2.12e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582     265 NASDADEGVNGEVVFSFDSGisrDIQEKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVN 344
Cdd:smart00112   1 SATDADSGENGKVTYSILSG---NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 9256582     345 DNAP 348
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 8.55e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 8.55e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  137 EQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSD---YFSLDveasdelSKSLWLELRKYLDREETPELHLLLT 213
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSID-------PSTGEITTAKPLDREEQSSYTLTVT 73

                        90       100
                ....*....|....*....|....*
gi 9256582  214 ATDGGKPELQGTVELLITVLDVNDN 238
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 577-670 3.83e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.83e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582  577 VSELVPrlvgAGHVVAKVRAVDADSGYNAWLSYELQPaaGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGE 656
Cdd:cd11304   6 VPENAP----PGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....
gi 9256582  657 PALTATATVLVSLV 670
Cdd:cd11304  80 PPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
247-341 3.98e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.51  E-value: 3.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582    247 YRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIqekFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKG 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN---FRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 9256582    327 SPPMSNHCKVLVKVL 341
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 478-563 9.55e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 9.55e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582     478 SARDADAQENALVSYSLVERRVGeralsNYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLD 557
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 9256582     558 ENDNAP 563
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 1.49e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.63  E-value: 1.49e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582     157 AADADIGANALLTYTLSPSD---YFSLDveasdelSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVL 233
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNddgLFSID-------PETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 9256582     234 DVNDNAP 240
Cdd:smart00112  75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 373-453 2.79e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.86  E-value: 2.79e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582     373 TVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 9256582     453 P 453
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 595-670 1.55e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 1.55e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9256582     595 RAVDADSGYNAWLSYELQPaaGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGEPALTATATVLVSLV 670
Cdd:smart00112   1 SATDADSGENGKVTYSILS--GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
575-669 2.27e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.33  E-value: 2.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582    575 GAVSELVPRlvgaGHVVAKVRAVDADSGYNAWLSYELQPaaGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDH 654
Cdd:pfam00028   3 ASVPENAPV----GTEVLTVTATDPDLGPNGRIFYSILG--GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 9256582    655 GEPALTATATVLVSL 669
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
460-556 6.44e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 6.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582    460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGeralsNYVSVHAESGKVYALQPLDHEELELLQFQVSARD 539
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG-----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 9256582    540 AGVPPLGSNVTLQVFVL 556
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
359-445 4.98e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 4.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582    359 IREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWAT 438
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 9256582    439 ARVSVEV 445
Cdd:pfam00028  85 ATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 1.99e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.18  E-value: 1.99e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582   32 HYSIPEEAKHGTFVGRV-AQDLGLELAELVprLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWsaecsiHLELIA 110
Cdd:cd11304   3 EVSVPENAPPGTVVLTVsATDPDSGENGEV--TYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSY------TLTVTA 74

                        90       100
                ....*....|....*....|....
gi 9256582  111 -DRPLQVF----HVEVKVKDINDN 129
Cdd:cd11304  75 tDGGGPPLsstaTVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
140-233 7.59e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 7.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582    140 IFIPESRLLNSRFPIEGAADADIGANALLTYTLS---PSDYFSLDVEasdelskSLWLELRKYLDREETPELHLLLTATD 216
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPD-------TGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 9256582    217 GGKPELQGTVELLITVL 233
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 64-131 4.10e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.42  E-value: 4.10e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9256582      64 FRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWsaecsiHLELIA----DRPLQVF-HVEVKVKDINDNPP 131
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPEY------TLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 9.90e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 42.33  E-value: 9.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256582   33 YSIPEEAKHGTFVGRVAQDLGlelaELVPRLFRVASKTHRD---LLEVNLQNGILFVNSRIDREELCQWsaECSIHL-EL 108
Cdd:cd00031   4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEAlpsWLHWEPHSGILEGLEKLDREDKGVH--YISVSAaSL 77

                        90       100
                ....*....|....*....|.
gi 9256582  109 IADRPLQVFHVEVKVKDINDN 129
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 190-238 6.86e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 36.94  E-value: 6.86e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 9256582  190 KSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDN 238
Cdd:cd00031  50 HSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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