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Conserved domains on  [gi|9055200|ref|NP_061246|]
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cytokine receptor-like factor 3 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 181-267 9.19e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 9.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055200  181 PPVQIEELIEKPGGIIVRWCKVDDDFTA-QDYRLQFRKCTANHFEDVYV--GSETEFIVLHIDPNVDYQFRVCAR-GDGR 256
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPiTGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAVnGGGE 82

                        90
                ....*....|.
gi 9055200  257 QEWSPWSVPQT 267
Cdd:cd00063  83 SPPSESVTVTT 93
CC_brat-like super family cl29238
coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins; This family ...
 17-113 3.23e-03

coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins; This family contains the coiled-coil (CC) region of Drosophila brain tumor (Brat), a translational repressor that belongs to the tripartite motif (TRIM) protein superfamily. TRIM proteins play important roles in various cellular processes and are involved in many diseases which consists of two B-box domains and a coiled-coil (CC) domain at the N-terminal region, and an NHL domain at the C-terminus. Brat localizes at the basal cortex during asymmetric division of Drosophila neuroblasts by directly interacting with the scaffolding protein Miranda (Mira), which it does through the CC-NHL domain tandem, indicating that the function of the Brat CC domain is to assemble Brat-NHL in dimeric form which is necessary for Mira binding. Brat CC forms an elongated antiparallel dimer similar to its other TRIM protein counterparts, but the overall length of Brat CC dimer is shorter than the TRIMs.


The actual alignment was detected with superfamily member smart00502:

Pssm-ID: 475168  Cd Length: 127  Bit Score: 37.63  E-value: 3.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055200      17 RENVEAAQSYRRELGQRLQGLREAQRQIKESASQTRDVLKQHFSDLKgtlgKLLDERLVTLLQEVDTIEQETIKPLDD-- 94
Cdd:smart00502   6 EELLTKLRKKAAELEDALKQLISIIQEVEENAADVEAQIKAAFDELR----NALNKRKKQLLEDLEEQKENKLKVLEQql 81

                           90       100
                   ....*....|....*....|....
gi 9055200      95 -----CQKLIEHGVNTADDLVREG 113
Cdd:smart00502  82 esltqKQEKLSHAINFTEEALNSG 105
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 181-267 9.19e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 9.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055200  181 PPVQIEELIEKPGGIIVRWCKVDDDFTA-QDYRLQFRKCTANHFEDVYV--GSETEFIVLHIDPNVDYQFRVCAR-GDGR 256
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPiTGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAVnGGGE 82

                        90
                ....*....|.
gi 9055200  257 QEWSPWSVPQT 267
Cdd:cd00063  83 SPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
181-260 1.64e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.39  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055200    181 PPVQIEELIEK-PGGIIVRW---CKVDDDFTaqDYRLQFRKCTANHFEDVY--VGSETEFIVLHIDPNVDYQFRVCAR-G 253
Cdd:pfam00041   1 SAPSNLTVTDVtSTSLTVSWtppPDGNGPIT--GYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQAVnG 78


                  ....*..
gi 9055200    254 DGRQEWS 260
Cdd:pfam00041  79 GGEGPPS 85
BBC smart00502
B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains
 17-113 3.23e-03

B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains


Pssm-ID: 128778  Cd Length: 127  Bit Score: 37.63  E-value: 3.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055200      17 RENVEAAQSYRRELGQRLQGLREAQRQIKESASQTRDVLKQHFSDLKgtlgKLLDERLVTLLQEVDTIEQETIKPLDD-- 94
Cdd:smart00502   6 EELLTKLRKKAAELEDALKQLISIIQEVEENAADVEAQIKAAFDELR----NALNKRKKQLLEDLEEQKENKLKVLEQql 81

                           90       100
                   ....*....|....*....|....
gi 9055200      95 -----CQKLIEHGVNTADDLVREG 113
Cdd:smart00502  82 esltqKQEKLSHAINFTEEALNSG 105
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 4-102 3.52e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 39.94  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055200     4 AMEPEPEVLLQEARENveaaqsyRRELGQRLQGLREAQRQIKESASQtrdvLKQHFSDLKGTLGK---LLDErlvTLLQE 80
Cdd:COG3096  829 AFAPDPEAELAALRQR-------RSELERELAQHRAQEQQLRQQLDQ----LKEQLQLLNKLLPQanlLADE---TLADR 894

                         90       100
                 ....*....|....*....|..
gi 9055200    81 VDTIEQETIKPLDDCQKLIEHG 102
Cdd:COG3096  895 LEELREELDAAQEAQAFIQQHG 916
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 181-252 8.18e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 35.28  E-value: 8.18e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9055200     181 PPVQIEELIEKPGGIIVRWCKVDDDFTAQD---YRLQFRKCTANHFEDVYVGSETEFIVLHIDPNVDYQFRVCAR 252
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYivgYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 181-267 9.19e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 9.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055200  181 PPVQIEELIEKPGGIIVRWCKVDDDFTA-QDYRLQFRKCTANHFEDVYV--GSETEFIVLHIDPNVDYQFRVCAR-GDGR 256
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPiTGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAVnGGGE 82

                        90
                ....*....|.
gi 9055200  257 QEWSPWSVPQT 267
Cdd:cd00063  83 SPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
181-260 1.64e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.39  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055200    181 PPVQIEELIEK-PGGIIVRW---CKVDDDFTaqDYRLQFRKCTANHFEDVY--VGSETEFIVLHIDPNVDYQFRVCAR-G 253
Cdd:pfam00041   1 SAPSNLTVTDVtSTSLTVSWtppPDGNGPIT--GYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQAVnG 78


                  ....*..
gi 9055200    254 DGRQEWS 260
Cdd:pfam00041  79 GGEGPPS 85
BBC smart00502
B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains
 17-113 3.23e-03

B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains


Pssm-ID: 128778  Cd Length: 127  Bit Score: 37.63  E-value: 3.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055200      17 RENVEAAQSYRRELGQRLQGLREAQRQIKESASQTRDVLKQHFSDLKgtlgKLLDERLVTLLQEVDTIEQETIKPLDD-- 94
Cdd:smart00502   6 EELLTKLRKKAAELEDALKQLISIIQEVEENAADVEAQIKAAFDELR----NALNKRKKQLLEDLEEQKENKLKVLEQql 81

                           90       100
                   ....*....|....*....|....
gi 9055200      95 -----CQKLIEHGVNTADDLVREG 113
Cdd:smart00502  82 esltqKQEKLSHAINFTEEALNSG 105
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 4-102 3.52e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 39.94  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055200     4 AMEPEPEVLLQEARENveaaqsyRRELGQRLQGLREAQRQIKESASQtrdvLKQHFSDLKGTLGK---LLDErlvTLLQE 80
Cdd:COG3096  829 AFAPDPEAELAALRQR-------RSELERELAQHRAQEQQLRQQLDQ----LKEQLQLLNKLLPQanlLADE---TLADR 894

                         90       100
                 ....*....|....*....|..
gi 9055200    81 VDTIEQETIKPLDDCQKLIEHG 102
Cdd:COG3096  895 LEELREELDAAQEAQAFIQQHG 916
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 181-252 8.18e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 35.28  E-value: 8.18e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9055200     181 PPVQIEELIEKPGGIIVRWCKVDDDFTAQD---YRLQFRKCTANHFEDVYVGSETEFIVLHIDPNVDYQFRVCAR 252
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYivgYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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