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Conserved domains on  [gi|8923565|ref|NP_060370|]
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small ribosomal subunit protein mS38 [Homo sapiens]

Protein Classification

aurora kinase A-interacting protein( domain architecture ID 19230298)

aurora kinase A-interacting protein is a DUF1713 domain-containing protein that may act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
At5g63150_CTD cd23699
C-terminal domain of Arabidopsis thaliana At5g63150 and similar proteins; At5g63150, also ...
 125-154 6.05e-10

C-terminal domain of Arabidopsis thaliana At5g63150 and similar proteins; At5g63150, also known as mS38, is a component of the small subunit (SSU) in RNA-rich Arabidopsis thaliana mitochondrial ribosome (mitoribosome). Thi model corresponds to the C-terminal domain of At5g63150.


:

Pssm-ID: 467912  Cd Length: 30  Bit Score: 52.38  E-value: 6.05e-10
                        10        20        30
                ....*....|....*....|....*....|
gi 8923565  125 IQCKNVLKIRRRKMNHHKYRKLVKKTRFLR 154
Cdd:cd23699   1 IQADSVKRKRKRKMNKHKYRKLRKRTRFLR 30
 
Name Accession Description Interval E-value
At5g63150_CTD cd23699
C-terminal domain of Arabidopsis thaliana At5g63150 and similar proteins; At5g63150, also ...
 125-154 6.05e-10

C-terminal domain of Arabidopsis thaliana At5g63150 and similar proteins; At5g63150, also known as mS38, is a component of the small subunit (SSU) in RNA-rich Arabidopsis thaliana mitochondrial ribosome (mitoribosome). Thi model corresponds to the C-terminal domain of At5g63150.


Pssm-ID: 467912  Cd Length: 30  Bit Score: 52.38  E-value: 6.05e-10
                        10        20        30
                ....*....|....*....|....*....|
gi 8923565  125 IQCKNVLKIRRRKMNHHKYRKLVKKTRFLR 154
Cdd:cd23699   1 IQADSVKRKRKRKMNKHKYRKLRKRTRFLR 30
COX24_C pfam08213
Mitochondrial mRNA-processing protein COX24, C-terminal; This domain of unknown function is ...
 127-157 4.47e-08

Mitochondrial mRNA-processing protein COX24, C-terminal; This domain of unknown function is found at the C terminal end of Mitochondrial small ribosomal subunit protein mS38, also known as Mitochondrial mRNA-processing protein COX24 in yeast which is involved in the splicing of the COX1 mRNA. COX24 is a component of the mitochondrial ribosome (mitoribosome), responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. This domain is also found in COX24 mammalian homolog Aurora kinase A-interacting protein. This entry also includes uncharacterized proteins from bacteria.


Pssm-ID: 429868  Cd Length: 31  Bit Score: 47.27  E-value: 4.47e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 8923565    127 CKNVLKIRRRKMNHHKYRKLVKKTRFLRRKV 157
Cdd:pfam08213   1 ADSVLRKRRKKMKKHKYKKLRKRTRFLRRKL 31
 
Name Accession Description Interval E-value
At5g63150_CTD cd23699
C-terminal domain of Arabidopsis thaliana At5g63150 and similar proteins; At5g63150, also ...
 125-154 6.05e-10

C-terminal domain of Arabidopsis thaliana At5g63150 and similar proteins; At5g63150, also known as mS38, is a component of the small subunit (SSU) in RNA-rich Arabidopsis thaliana mitochondrial ribosome (mitoribosome). Thi model corresponds to the C-terminal domain of At5g63150.


Pssm-ID: 467912  Cd Length: 30  Bit Score: 52.38  E-value: 6.05e-10
                        10        20        30
                ....*....|....*....|....*....|
gi 8923565  125 IQCKNVLKIRRRKMNHHKYRKLVKKTRFLR 154
Cdd:cd23699   1 IQADSVKRKRKRKMNKHKYRKLRKRTRFLR 30
COX24_C pfam08213
Mitochondrial mRNA-processing protein COX24, C-terminal; This domain of unknown function is ...
 127-157 4.47e-08

Mitochondrial mRNA-processing protein COX24, C-terminal; This domain of unknown function is found at the C terminal end of Mitochondrial small ribosomal subunit protein mS38, also known as Mitochondrial mRNA-processing protein COX24 in yeast which is involved in the splicing of the COX1 mRNA. COX24 is a component of the mitochondrial ribosome (mitoribosome), responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. This domain is also found in COX24 mammalian homolog Aurora kinase A-interacting protein. This entry also includes uncharacterized proteins from bacteria.


Pssm-ID: 429868  Cd Length: 31  Bit Score: 47.27  E-value: 4.47e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 8923565    127 CKNVLKIRRRKMNHHKYRKLVKKTRFLRRKV 157
Cdd:pfam08213   1 ADSVLRKRRKKMKKHKYKKLRKRTRFLRRKL 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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