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Conserved domains on  [gi|406601114|ref|NP_060245|]
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tetratricopeptide repeat protein 19, mitochondrial isoform 1 precursor [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 227-348 1.51e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.62  E-value: 1.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 227 EEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAS 306
Cdd:COG3914   68 AAAAAALLLLAALLELAALLLQALGRYEEALALYRRALAL--------NPDNAEALFNLGNLLLALGRLEEALAALRRAL 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 406601114 307 DLArqinhPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQA 348
Cdd:COG3914  140 ALN-----PDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 102-348 2.97e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.11  E-value: 2.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 102 RAKLSIMKDEPEEAELILHDALRLAYQTdnkkaiTYTYDLMANLAFIRGQLENAEQLFKATMSyllgggmKQEDNAiiEI 181
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDPET------VEAHLALGNLYRRRGEYDRAIRIHQKLLE-------RDPDRA--EA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 182 SLKLASIYAAQNRQEFAVAGYEFCISTLEEKIE----------REKELAEDI-----MSVEEKANTHLLLGMcldacARY 246
Cdd:COG2956   79 LLELAQDYLKAGLLDRAEELLEKLLELDPDDAEalrllaeiyeQEGDWEKAIevlerLLKLGPENAHAYCEL-----AEL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 247 LLFSKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLarqinHPELHMVLSNLAA 326
Cdd:COG2956  154 YLEQGDYDEAIEALEKALKL--------DPDCARALLLLAELYLEQGDYEEAIAALERALEQ-----DPDYLPALPRLAE 220

                        250       260
                 ....*....|....*....|..
gi 406601114 327 VLMHRERYTQAKEIYQEALKQA 348
Cdd:COG2956  221 LYEKLGDPEEALELLRKALELD 242
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 227-348 1.51e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.62  E-value: 1.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 227 EEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAS 306
Cdd:COG3914   68 AAAAAALLLLAALLELAALLLQALGRYEEALALYRRALAL--------NPDNAEALFNLGNLLLALGRLEEALAALRRAL 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 406601114 307 DLArqinhPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQA 348
Cdd:COG3914  140 ALN-----PDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176
TPR_12 pfam13424
Tetratricopeptide repeat;
230-311 2.64e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.46  E-value: 2.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114  230 ANTHLLLGMCLDACARYLlfskqpsQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLA 309
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYD-------EALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75


                  ..
gi 406601114  310 RQ 311
Cdd:pfam13424  76 EK 77
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 243-349 9.69e-07

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 50.69  E-value: 9.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 243 CARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAY------IYMQRASDLARQiNHPE 316
Cdd:NF040586 398 QVRYLYLRGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEAReldedtLERQRRVLGLGE-DHPH 476

                         90       100       110
                 ....*....|....*....|....*....|...
gi 406601114 317 LHMVLSNLAAVLMHRERYTQAKEIYQEALKQAK 349
Cdd:NF040586 477 TLMTAGGLGADLRALGRFREALELDEETLERHR 509
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 102-348 2.97e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.11  E-value: 2.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 102 RAKLSIMKDEPEEAELILHDALRLAYQTdnkkaiTYTYDLMANLAFIRGQLENAEQLFKATMSyllgggmKQEDNAiiEI 181
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDPET------VEAHLALGNLYRRRGEYDRAIRIHQKLLE-------RDPDRA--EA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 182 SLKLASIYAAQNRQEFAVAGYEFCISTLEEKIE----------REKELAEDI-----MSVEEKANTHLLLGMcldacARY 246
Cdd:COG2956   79 LLELAQDYLKAGLLDRAEELLEKLLELDPDDAEalrllaeiyeQEGDWEKAIevlerLLKLGPENAHAYCEL-----AEL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 247 LLFSKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLarqinHPELHMVLSNLAA 326
Cdd:COG2956  154 YLEQGDYDEAIEALEKALKL--------DPDCARALLLLAELYLEQGDYEEAIAALERALEQ-----DPDYLPALPRLAE 220

                        250       260
                 ....*....|....*....|..
gi 406601114 327 VLMHRERYTQAKEIYQEALKQA 348
Cdd:COG2956  221 LYEKLGDPEEALELLRKALELD 242
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 252-345 8.44e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 44.52  E-value: 8.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 252 QPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQIN---HPELHMVLSNLAAVL 328
Cdd:NF040586 620 RLEEALELAEDTYERYRRRFGPDHPDTLAAALSLANDLRALGDADEARELAREVLDRYRRVLgedHPFTLACRNNLAVLL 699

                         90
                 ....*....|....*..
gi 406601114 329 MHRERYTQAKEIYQEAL 345
Cdd:NF040586 700 RALGDPEEARELAEAAL 716
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 255-345 4.52e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 42.21  E-value: 4.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 255 QAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI----NHPELHMVLSNLAAVLMH 330
Cdd:NF040586 538 EALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVlggpDHPDTLRAAKSLAVALRR 617

                         90
                 ....*....|....*
gi 406601114 331 RERYTQAKEIYQEAL 345
Cdd:NF040586 618 AGRLEEALELAEDTY 632
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 244-347 1.58e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 40.67  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 244 ARYLLFSKQPSQAQRMYEKALQ-ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHM 319
Cdd:NF040586 569 ARDLRELGRYAEALDLLEEALErYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRfgpDHPDTLA 648

                         90       100
                 ....*....|....*....|....*...
gi 406601114 320 VLSNLAAVLMHRERYTQAKEIYQEALKQ 347
Cdd:NF040586 649 AALSLANDLRALGDADEARELAREVLDR 676
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 102-315 5.40e-03

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 38.45  E-value: 5.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114  102 RAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYdLMANLAFIRGQLENAEQLFKATMSYLLGGGMKqedNAIIEI 181
Cdd:pfam17874   7 RAQLAISKGDAERALELAEQALALLPEDDLLARGLATF-VLGEAYLCLGDLDAALQAMREAEALARRADSP---HVTLWA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114  182 SLKLASIYAAQNRQEFAVAGYEFCIstleeKIEREKELAEDIMSveekanthlllGMCLDACARYLLFSKQPSQAQRMYE 261
Cdd:pfam17874  83 LLQQGEILRAQGRLHQALETYQQAL-----QLARDHGLQHLPLH-----------GFLLVGLADLLYEWNDLEEAEQHAQ 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 406601114  262 KALQISEEIQGERHPQTIVLMSDLATtldAQGRFDEAYIYMQRASDLARQINHP 315
Cdd:pfam17874 147 QGIQLGRQWEPDAAVDAYVLLARIAL---AQGELEEALTLLRRAELLARQSFFH 197
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 227-348 1.51e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.62  E-value: 1.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 227 EEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAS 306
Cdd:COG3914   68 AAAAAALLLLAALLELAALLLQALGRYEEALALYRRALAL--------NPDNAEALFNLGNLLLALGRLEEALAALRRAL 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 406601114 307 DLArqinhPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQA 348
Cdd:COG3914  140 ALN-----PDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176
TPR_12 pfam13424
Tetratricopeptide repeat;
230-311 2.64e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.46  E-value: 2.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114  230 ANTHLLLGMCLDACARYLlfskqpsQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLA 309
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYD-------EALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75


                  ..
gi 406601114  310 RQ 311
Cdd:pfam13424  76 EK 77
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 244-367 1.72e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 49.62  E-value: 1.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 244 ARYLLFSKQPSQAQRMYEKALQISeeiqgerhPQTIVLMSDLATTLDAQGRFDEAYIYMQRAsdLARQINHPElhmVLSN 323
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEKALRLD--------PDNADALLDLAEALLAAGDTEEAEELLERA--LALDPDNPE---ALYL 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 406601114 324 LAAVLMHRERYTQAKEIYQEALKQAklkKDEISVQHIREELAEL 367
Cdd:COG4235   91 LGLAAFQQGDYAEAIAAWQKLLALL---PADAPARLLEASIAEA 131
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 243-349 9.69e-07

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 50.69  E-value: 9.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 243 CARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAY------IYMQRASDLARQiNHPE 316
Cdd:NF040586 398 QVRYLYLRGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEAReldedtLERQRRVLGLGE-DHPH 476

                         90       100       110
                 ....*....|....*....|....*....|...
gi 406601114 317 LHMVLSNLAAVLMHRERYTQAKEIYQEALKQAK 349
Cdd:NF040586 477 TLMTAGGLGADLRALGRFREALELDEETLERHR 509
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 68-356 5.36e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.45  E-value: 5.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114  68 RPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYT-YDLMANLA 146
Cdd:COG3914    9 LAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAlLELAALLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 147 FIRGQLENAEQLFKATMsyllgggmkQEDNAIIEISLKLASIYAAQNRQEFAVAgyefcisTLEEKIEREKELAEdimsv 226
Cdd:COG3914   89 QALGRYEEALALYRRAL---------ALNPDNAEALFNLGNLLLALGRLEEALA-------ALRRALALNPDFAE----- 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 227 eekanTHLLLGMCLDACaryllfsKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAS 306
Cdd:COG3914  148 -----AYLNLGEALRRL-------GRLEEAIAALRRALEL--------DPDNAEALNNLGNALQDLGRLEEAIAAYRRAL 207

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 406601114 307 DLArqinhPELHMVLSNLAAVLMHRERYTQAkEIYQEALKQAKLKKDEIS 356
Cdd:COG3914  208 ELD-----PDNADAHSNLLFALRQACDWEVY-DRFEELLAALARGPSELS 251
TPR_12 pfam13424
Tetratricopeptide repeat;
277-349 5.97e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 43.92  E-value: 5.97e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 406601114  277 QTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAK 349
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLlgpDHPLTATTLLNLGRLYLELGRYEEALELLERALALAE 76
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
230-346 8.16e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.54  E-value: 8.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 230 ANTHLLLGMCLDACARYllfskqpSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLa 309
Cdd:COG0457    8 AEAYNNLGLAYRRLGRY-------EEAIEDYEKALEL--------DPDDAEALYNLGLAYLRLGRYEEALADYEQALEL- 71

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 406601114 310 rqinHPELHMVLSNLAAVLMHRERYTQAKEIYQEALK 346
Cdd:COG0457   72 ----DPDDAEALNNLGLALQALGRYEEALEDYDKALE 104
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
230-346 1.05e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.54  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 230 ANTHLLLGMCLDACARYllfskqpSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLa 309
Cdd:COG0457   42 AEALYNLGLAYLRLGRY-------EEALADYEQALEL--------DPDDAEALNNLGLALQALGRYEEALEDYDKALEL- 105

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 406601114 310 rqinHPELHMVLSNLAAVLMHRERYTQAKEIYQEALK 346
Cdd:COG0457  106 ----DPDDAEALYNLGLALLELGRYDEAIEAYERALE 138
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 244-348 1.20e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.80  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 244 ARYLLFSKQPSQAQRMYEKALqiseeiqgERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLarqinHPELHMVLSN 323
Cdd:COG4783   11 AQALLLAGDYDEAEALLEKAL--------ELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALEL-----DPDEPEARLN 77

                         90       100
                 ....*....|....*....|....*
gi 406601114 324 LAAVLMHRERYTQAKEIYQEALKQA 348
Cdd:COG4783   78 LGLALLKAGDYDEALALLEKALKLD 102
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
246-348 1.31e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 43.24  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 246 YLLFSKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYmQRASDLarqinHPELHMVLSNLA 325
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALEL--------DPDNADALNNLGLLLLEQGRYDEAIAL-EKALKL-----DPNNAEALLNLA 66

                         90       100
                 ....*....|....*....|...
gi 406601114 326 AVLMHRERYTQAKEIYQEALKQA 348
Cdd:COG3063   67 ELLLELGDYDEALAYLERALELD 89
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 102-348 2.97e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.11  E-value: 2.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 102 RAKLSIMKDEPEEAELILHDALRLAYQTdnkkaiTYTYDLMANLAFIRGQLENAEQLFKATMSyllgggmKQEDNAiiEI 181
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDPET------VEAHLALGNLYRRRGEYDRAIRIHQKLLE-------RDPDRA--EA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 182 SLKLASIYAAQNRQEFAVAGYEFCISTLEEKIE----------REKELAEDI-----MSVEEKANTHLLLGMcldacARY 246
Cdd:COG2956   79 LLELAQDYLKAGLLDRAEELLEKLLELDPDDAEalrllaeiyeQEGDWEKAIevlerLLKLGPENAHAYCEL-----AEL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 247 LLFSKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLarqinHPELHMVLSNLAA 326
Cdd:COG2956  154 YLEQGDYDEAIEALEKALKL--------DPDCARALLLLAELYLEQGDYEEAIAALERALEQ-----DPDYLPALPRLAE 220

                        250       260
                 ....*....|....*....|..
gi 406601114 327 VLMHRERYTQAKEIYQEALKQA 348
Cdd:COG2956  221 LYEKLGDPEEALELLRKALELD 242
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 244-348 3.33e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.26  E-value: 3.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 244 ARYLLFSKQPSQAQRMYEKALqiseeiqgERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAsdLARQINHPELHMvlsN 323
Cdd:COG4783   45 GEILLQLGDLDEAIVLLHEAL--------ELDPDEPEARLNLGLALLKAGDYDEALALLEKA--LKLDPEHPEAYL---R 111

                         90       100
                 ....*....|....*....|....*
gi 406601114 324 LAAVLMHRERYTQAKEIYQEALKQA 348
Cdd:COG4783  112 LARAYRALGRPDEAIAALEKALELD 136
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 247-351 7.59e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.64  E-value: 7.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 247 LLFSKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLArqinhPELHMVLSNLAA 326
Cdd:COG5010   64 YNKLGDFEESLALLEQALQL--------DPNNPELYYNLALLYSRSGDKDEAKEYYEKALALS-----PDNPNAYSNLAA 130

                         90       100
                 ....*....|....*....|....*
gi 406601114 327 VLMHRERYTQAKEIYQEALKQAKLK 351
Cdd:COG5010  131 LLLSLGQDDEAKAALQRALGTSPLK 155
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 252-345 8.44e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 44.52  E-value: 8.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 252 QPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQIN---HPELHMVLSNLAAVL 328
Cdd:NF040586 620 RLEEALELAEDTYERYRRRFGPDHPDTLAAALSLANDLRALGDADEARELAREVLDRYRRVLgedHPFTLACRNNLAVLL 699

                         90
                 ....*....|....*..
gi 406601114 329 MHRERYTQAKEIYQEAL 345
Cdd:NF040586 700 RALGDPEEARELAEAAL 716
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
230-370 3.71e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.53  E-value: 3.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 230 ANTHLLLGMCLDACARYllfskqpSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLA 309
Cdd:COG0457   76 AEALNNLGLALQALGRY-------EEALEDYDKALEL--------DPDDAEALYNLGLALLELGRYDEAIEAYERALELD 140

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 406601114 310 rqinhPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAKLKKDEISVQHIREELAELSKK 370
Cdd:COG0457  141 -----PDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVL 196
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 255-345 4.52e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 42.21  E-value: 4.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 255 QAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI----NHPELHMVLSNLAAVLMH 330
Cdd:NF040586 538 EALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVlggpDHPDTLRAAKSLAVALRR 617

                         90
                 ....*....|....*
gi 406601114 331 RERYTQAKEIYQEAL 345
Cdd:NF040586 618 AGRLEEALELAEDTY 632
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 252-349 4.72e-04

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 41.91  E-value: 4.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114  252 QPSQAQRMYEKALQISEEiqgERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQINHPELHMV-LSNLAAVLMH 330
Cdd:pfam17874  16 DAERALELAEQALALLPE---DDLLARGLATFVLGEAYLCLGDLDAALQAMREAEALARRADSPHVTLWaLLQQGEILRA 92

                          90
                  ....*....|....*....
gi 406601114  331 RERYTQAKEIYQEALKQAK 349
Cdd:pfam17874  93 QGRLHQALETYQQALQLAR 111
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 134-349 7.60e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 7.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 134 AITYTYDLMANLAFIRGQLENAEQLFKAtmsyllgggMKQEDNAIIEISLKLASIYaaQNRQEFAVAgyefcISTLEEKI 213
Cdd:COG2956    6 AAALGWYFKGLNYLLNGQPDKAIDLLEE---------ALELDPETVEAHLALGNLY--RRRGEYDRA-----IRIHQKLL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 214 EREkelaedimsvEEKANTHLLLgmcldacARYLLFSKQPSQAQRMYEKALQISeeiqgerhPQTIVLMSDLATTLDAQG 293
Cdd:COG2956   70 ERD----------PDRAEALLEL-------AQDYLKAGLLDRAEELLEKLLELD--------PDDAEALRLLAEIYEQEG 124

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 406601114 294 RFDEAYIYMQRASDLArqinhPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAK 349
Cdd:COG2956  125 DWEKAIEVLERLLKLG-----PENAHAYCELAELYLEQGDYDEAIEALEKALKLDP 175
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 244-347 1.58e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 40.67  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114 244 ARYLLFSKQPSQAQRMYEKALQ-ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHM 319
Cdd:NF040586 569 ARDLRELGRYAEALDLLEEALErYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRfgpDHPDTLA 648

                         90       100
                 ....*....|....*....|....*...
gi 406601114 320 VLSNLAAVLMHRERYTQAKEIYQEALKQ 347
Cdd:NF040586 649 AALSLANDLRALGDADEARELAREVLDR 676
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
273-346 2.72e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.22  E-value: 2.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 406601114 273 ERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLarqinHPELHMVLSNLAAVLMHRERYTQAKEIYQEALK 346
Cdd:COG0457    2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL-----DPDDAEALYNLGLAYLRLGRYEEALADYEQALE 70
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 102-315 5.40e-03

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 38.45  E-value: 5.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114  102 RAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYdLMANLAFIRGQLENAEQLFKATMSYLLGGGMKqedNAIIEI 181
Cdd:pfam17874   7 RAQLAISKGDAERALELAEQALALLPEDDLLARGLATF-VLGEAYLCLGDLDAALQAMREAEALARRADSP---HVTLWA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601114  182 SLKLASIYAAQNRQEFAVAGYEFCIstleeKIEREKELAEDIMSveekanthlllGMCLDACARYLLFSKQPSQAQRMYE 261
Cdd:pfam17874  83 LLQQGEILRAQGRLHQALETYQQAL-----QLARDHGLQHLPLH-----------GFLLVGLADLLYEWNDLEEAEQHAQ 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 406601114  262 KALQISEEIQGERHPQTIVLMSDLATtldAQGRFDEAYIYMQRASDLARQINHP 315
Cdd:pfam17874 147 QGIQLGRQWEPDAAVDAYVLLARIAL---AQGELEEALTLLRRAELLARQSFFH 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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